211 research outputs found

    Influential Article Review - Journal Progression and Organizational Model

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    This paper examines journal research. We present insights from a highly influential paper. Here are the highlights from this paper: This commentary reflects on how the themes in the Journal of Organization Design have evolved along with the field of organization design itself. Using topic modeling of abstracts, I assess the key topics or themes in the Journal of Organization Design and compare them to themes underlying design studies in mainstream management journals. I propose some mechanisms behind the differences and similarities and offer some implications for the future of the journal. For our overseas readers, we then present the insights from this paper in Spanish, French, Portuguese, and German

    Roam on Little Gypsy Sweetheart

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    Photograph of Sid Hall; Illustration of gypsy woman holding tambourine within frame; Background illustration of wagon by campfirehttps://scholarsjunction.msstate.edu/cht-sheet-music/12520/thumbnail.jp

    The American Psychiatric Association’s Guideline for Major Depressive Disorder: A Commentary

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    The American Psychiatric Association (APA) published a new guideline for Major Depressive Disorder (MDD) which will undoubtedly be used by many practitioners to guide clinical decision-making. In fact, it is non-psychiatrist clinicians who prescribe the majority of antidepressants (AD). We review the APA’s most recent guideline on MDD and report on our observations

    Effects of canopy-mediated abrasion and water flow on the early colonisation of turf-forming algae

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    Algal canopies form predictable associations with the benthic understorey, and canopy-mediated processes may maintain these associations. Three canopy-mediated processes that are inherently linked are water flow through a canopy, abrasion of the substrate by the canopy, and light penetration. These processes were experimentally reduced to test the hypotheses that turf-forming algae would be: (1) positively affected by reduced abrasion by kelp canopies; (2) positively affected by reduced water flow; and (3) negatively affected by shading (reduced light). Biomass of turf-forming algae was greater when abrasion was reduced, but less when light was reduced. In contrast to predictions, reduced water flow had a negative effect on the percentage cover and biomass of turf-forming algae, rejecting the second hypothesis. It seems, however, that this negative effect was caused by an increase in shading associated with reduced canopy movement, not a reduction of water flow per se. None of the factors accounted for all of the change seen in understorey algae, indicating that it is important to study the interactive effects of physical processes.Bayden D. Russel

    Do acute elevations of serum creatinine in primary care engender an increased mortality risk?

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    Background: The significant impact Acute Kidney Injury (AKI) has on patient morbidity and mortality emphasizes the need for early recognition and effective treatment. AKI presenting to or occurring during hospitalisation has been widely studied but little is known about the incidence and outcomes of patients experiencing acute elevations in serum creatinine in the primary care setting where people are not subsequently admitted to hospital. The aim of this study was to define this incidence and explore its impact on mortality. Methods: The study cohort was identified by using hospital data bases over a six month period. Inclusion criteria: People with a serum creatinine request during the study period, 18 or over and not on renal replacement therapy. The patients were stratified by a rise in serum creatinine corresponding to the Acute Kidney Injury Network (AKIN) criteria for comparison purposes. Descriptive and survival data were then analysed. Ethical approval was granted from National Research Ethics Service (NRES) Committee South East Coast and from the National Information Governance Board. Results: The total study population was 61,432. 57,300 subjects with ‘no AKI’, mean age 64.The number (mean age) of acute serum creatinine rises overall were, ‘AKI 1’ 3,798 (72), ‘AKI 2’ 232 (73), and ‘AKI 3’ 102 (68) which equates to an overall incidence of 14,192 pmp/year (adult). Unadjusted 30 day survival was 99.9% in subjects with ‘no AKI’, compared to 98.6%, 90.1% and 82.3% in those with ‘AKI 1’, ‘AKI 2’ and ‘AKI 3’ respectively. After multivariable analysis adjusting for age, gender, baseline kidney function and co-morbidity the odds ratio of 30 day mortality was 5.3 (95% CI 3.6, 7.7), 36.8 (95% CI 21.6, 62.7) and 123 (95% CI 64.8, 235) respectively, compared to those without acute serum creatinine rises as defined. Conclusions: People who develop acute elevations of serum creatinine in primary care without being admitted to hospital have significantly worse outcomes than those with stable kidney function

    Golimumab induction and maintenance for moderate to severe ulcerative colitis: results from GO-COLITIS (Golimumab: a Phase 4, UK, open label, single arm study on its utilization and impact in ulcerative Colitis)

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    Objective GO-COLITIS aimed to measure the effectiveness of subcutaneous golimumab in tumour necrosis factor-α antagonist–naive patients with moderate to severe ulcerative colitis (UC) despite conventional treatment. Design GO-COLITIS was an open label, single arm, phase 4 study with a pragmatic design which reflected UK clinical practice. Adult patients were eligible if diagnosed with UC ≄3 months, partial Mayo score (PMS) 4–9. Patients received subcutaneous golimumab induction (200 mg initially and 100 mg at week 2) followed at week 6 by 50 mg or 100 mg (depending on weight) every 4 weeks until week 54 with a 12-week follow-up. Efficacy was measured by PMS at baseline, week 6, 30, 54 and 66. Health-related quality of life (HRQoL; Inflammatory Bowel Disease Questionnaire (IBDQ) and EuroQol Group 5 Dimensions Health Questionnaire (EQ-5D)) was assessed at baseline, week 6 and week 54. All safety adverse events (AEs) were recorded. Results 207 patients were enrolled and 205 received golimumab (full analysis set (FAS)205). At week 6, 68.8% (95% CI 62.0% to 75.1%) and 38.5% (95% CI 31.8% to 45.6%) of patients were in response and remission, respectively, using PMS. At the end of the induction phase, 140/141 patients in clinical response continued into the maintenance phase (Maintenance FAS). Sustained clinical response through week 54 was achieved in 51/205 (24.9%) of the FAS205 population and 51/140 (36.4%) of the Maintenance FAS population. Statistically significant improvements from baseline to week 6 were observed for the IBDQ total score and for each IBDQ domain score (bowel symptoms, emotional function, systemic symptoms and social function), as well as the EQ-5D index score and associated visual analogue scale score (p<0.0001). Improvement of HRQoL was sustained through week 54. Serious AEs leading to treatment discontinuation occurred in 8.8% of patients. Conclusion In this study measuring patient-reported outcomes in patients with moderate to severe UC, golimumab induced and maintained response as measured by PMS and significantly improved quality of life measures. Trial registration number NCT02092285; 2013-004583-56

    Medication and Supplement Use in Disability Football World Championships

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    Background Individuals with an impairment make up over 15% of the world’s population, many of whom can benefit greatly from participation in sport. The provision of medical services in disability sport is a challenging area with a lack of scientific evidence. Given the positive impact that sport can have on the people with an impairment, it is vital that measures are taken to better understand the medical issues posed by disability sport. It is well established that medications and supplements are over-used in sport, particularly within professional football, but there is no current evidence on medication or supplement use in elite disability football. Objective To examine and describe the use of medication and supplements in disability football, prior to and during international tournaments, and to identify the profile of substances used by category. Design Prospective, descriptive, cohort study. Setting International Blind Sport Association (IBSA) Football World Cup 2015 and the International Federation of Cerebral Palsy Football (IFCPF) World Cup 2015. Participants Two hundred and forty-two elite level disability footballers, classified with B1 visual impairment or cerebral palsy. Methods Team clinicians were asked to document all medication and supplements taken in the 48 hours prior to each match. Results This study recorded the use of 1648 substances in 242 players, with more than half (53.1%) classified as supplements. There was an overall rate of 1.26 substances used per player per match and a medication use rate of 0.59 medications per player per match. Seventy percent (170/242) of players reported using at least one substance per tournament, with 57.9% (140/242) using at least one prescribed medication (63.6% of players at IBSA World Games and 57.7% of players at IFCPF World Cup). The most commonly prescribed category of medications was non-steroidal anti-inflammatory drugs (NSAIDs), representing 39.3% of all reported medications. Conclusion This study highlights the potential overuse of medication and supplements in disability football, particularly in the use of NSAIDs. These trends are comparable to previous research in FIFA World Cup competitions

    Ants of the Belgian Congo

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    x, 1139 p., 45 leaves of plates : ill. (1 col.), maps ; 24 cm.Includes bibliographical references and index.pt 1. On the distribution of the ants of the Ethiopian and Malagasy regions / by Wm. M. Wheeler -- pt. 2. The ants collected by the American Museum Congo Expedition / by Wm. M. Wheeler -- pt. 3. The predaceous enemies of ants / by J. Bequaert -- pt. 4. Ants in their diverse relations to the plant world / by J. Bequaert -- pt. 5. The anatomy of certain plants from the Belgian Congo, with special reference to myrmecophytism / by I.W. Bailey -- pt. 6. Notes on a collection of West African myrmecophiles / by Wm. M. Mann -- pt. 7. Keys to the genera and subgenera of ants / by Wm. M. Wheeler -- pt. 8. A synonymic list of the ants of the Ethiopian region / by Wm. M. Wheeler -- pt. 9. A synonymic list of the ants of the Malagasy region / by Wm. M. Wheeler

    Comparing Notes: Recording and Criticism

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    This chapter charts the ways in which recording has changed the nature of music criticism. It both provides an overview of the history of recording and music criticism, from the advent of Edison’s Phonograph to the present day, and examines the issues arising from this new technology and the consequent transformation of critical thought and practice

    Bioinorganic Chemistry of Alzheimer’s Disease

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