Christian School Discipline: A Collaborative Approach to Improving Student Behavior

A Catholic elementary school systematically developed a comprehensive discipline program with input from the administrator, teachers, students, parents, and other members of the parish community. Developed around the themes of respect, spirituality, and responsibility, the program was systematically evaluated over the first year of a three-year period of implementation. Survey results of parents, teachers, and students indicate positive perceptions of the project by aU three groups

Beyond humanization and de-immunization: tolerization as a method for reducing the immunogenicity of biologics

Immune responses to some monoclonal antibodies (mAbs) and biologic proteins interfere with their efficacy due to the development of anti-drug antibodies (ADA). In the case of mAbs, most ADA target ‘foreign’ sequences present in the complementarity determining regions (CDRs). Humanization of the mAb sequence is one approach that has been used to render biologics less foreign to the human immune system. However, fully human mAbs can also drive immunogenicity. De-immunization (removing epitopes) has been used to reduce biologic protein immunogenicity. Here, we discuss a third approach to reducing the immunogenicity of biologics: introduction of Treg epitopes that stimulate Treg function and induce tolerance to the biologic protein. Supplementing humanization (replacing xenosequences with human) and de-immunization (reducing T effector epitopes) with tolerization (introducing Treg epitopes) where feasible, as a means of improving biologics ‘quality by design’, may lead to the development of ever more clinically effective, but less immunogenic, biologics

The end of the Pacific? Effects of sea level rise on Pacific Island livelihoods

As in the past, most Pacific Island people live today along island coasts and subsist largely on foods available both onshore and offshore. On at least two occasions in the 3500 years that Pacific Islands have been settled, sea level changes affected coastal bioproductivity to the extent that island societies were transformed in consequence. Over the past 200 years, sea level has been rising along most Pacific Island coasts causing loss of productive land through direct inundation (flooding), shoreline erosion and groundwater salinization. Responses have been largely uninformed, many unsuccessful. By the year 2100, sea level may be 1.2m higher than today. Together with other climate-linked changes and unsustainable human pressures on coastal zones, this will pose huge challenges for livelihoods. There is an urgent need for effective and sustainable adaptation of livelihoods to prepare for future sea level rise in the Pacific Islands region. There are also lessons to be learned from past failures, including the need for adaptive solutions that are environmentally and culturally appropriate, and those which appropriate decision makers are empowered to design and implement. Around the middle of the twenty-first century, traditional coastal livelihoods are likely to be difficult to sustain, so people in the region will need alternative food production systems. Within the next 20-30 years, it is likely that many coastal settlements will need to be relocated, partly or wholly. There are advantages in anticipating these needs and planning for them sooner rather than later. In many ways, the historical and modern Pacific will end within the next few decades. There will be fundamental irreversible changes in island geography, settlement patterns, subsistence systems, societies and economic development, forced by sea level rise and other factors. © 2013 The Author Singapore Journal of Tropical Geography © 2013 Department of Geography, National University of Singapore and Wiley Publishing Asia Pty Ltd