119 research outputs found
Ectopic high endothelial venules in pancreatic ductal adenocarcinoma: A unique site for targeted delivery
- Author
- Ager
- Ai
- Azzi
- Azzi
- Bahmani
- Bahmani
- Bazak
- Bhattacharyya
- Bisht
- Chauhan
- Chen
- Chiaravalli
- Colbeck
- Dancer
- Danhier
- Desai
- Di Maggio
- Dimou
- Din
- Fang
- Feig
- Ferrari
- Glazer
- Hemmerich
- Hiraoka
- Hiraoka
- Hiraoka
- Hsiao
- Kanda
- Kleeff
- Lee
- Lee
- Liu
- Long
- Longo
- Martinet
- Minchinton
- Neesse
- Nichols
- Pal
- Pandol
- Patra
- Pelaez-Luna
- Provenzano
- Rosenberg
- Ryan
- Sherman
- Siegel
- Singh
- Sohal
- Sykes
- Tavares
- Ueda
- Ying
- Zhang
- Zhu
- Publication venue
- eScholarship@UMassChan
- Publication date
- 01/12/2018
- Field of study
BACKGROUND: Nanomedicine offers an excellent opportunity to tackle treatment-refractory malignancies by enhancing the delivery of therapeutics to the tumor site. High endothelial venules (HEVs) are found primarily in lymph nodes or formed de novo in peripheral tissues during inflammatory responses. They express peripheral node addressin (PNAd), which is recognized by the monoclonal antibody MECA79.
METHODS: Here, we demonstrated that HEVs form de novo in human pancreatic ductal adenocarcinoma (PDAC). We engineered MECA79 coated nanoparticles (MECA79-NPs) that recognize these ectopic HEVs in PDAC.
FINDINGS: The trafficking of MECA79-NPs following intravenous delivery to human PDAC implanted in a humanized mouse model was more robust than non-conjugated NPs. Treatment with MECA79-Taxol-NPs augmented the delivery of Paclitaxel (Taxol) to the tumor site and significantly reduced the tumor size. This effect was associated with a higher apoptosis rate of PDAC cells and reduced vascularization within the tumor.
INTERPRETATION: Targeting the HEVs of PDAC using MECA79-NPs could lay the ground for the localized delivery of a wide variety of drugs including chemotherapeutic agents. FUND: National Institutes of Health (NIH) grants: T32-EB016652 (B.B.), NIH Cancer Core Grant CA034194 (L.D.S.), National Institute of Allergy and Infectious Diseases grants R01-AI126596 and R01-HL141815 (R.A.)
Four Linked Genes Participate in Controlling Sporulation Efficiency in Budding Yeast
- Author
- Amir Sherman
- Ben-Ari
- Brachmann
- Brauer
- Breen
- Christians
- Chu
- Darvasi
- Deutschbauer
- Doebley
- Drora Zenvirth
- El-Din El-Assal
- Garrett
- Germer
- Giora Ben-Ari
- Giora Simchen
- Harbison
- Heck
- Hoogendoorn
- Ihmels
- Jossi Hillel
- Kliebenstein
- Knop
- Kojima
- Lior David
- Liu
- Mackay
- Maloof
- Mauricio
- Michael Klutstein
- Norton
- Peters
- Polsinelli
- Primig
- Ross
- Sasaki
- Segre
- Sinha
- Steinmetz
- Steinmetz
- Takahashi
- Uri Lavi
- Winzeler
- Yano
- Publication venue
- Public Library of Science
- Publication date
- 01/01/2005
- Field of study
Quantitative traits are conditioned by several genetic determinants. Since such genes influence many important complex traits in various organisms, the identification of quantitative trait loci (QTLs) is of major interest, but still encounters serious difficulties. We detected four linked genes within one QTL, which participate in controlling sporulation efficiency in Saccharomyces cerevisiae. Following the identification of single nucleotide polymorphisms by comparing the sequences of 145 genes between the parental strains SK1 and S288c, we analyzed the segregating progeny of the cross between them. Through reciprocal hemizygosity analysis, four genes, RAS2, PMS1, SWS2, and FKH2, located in a region of 60 kilobases on Chromosome 14, were found to be associated with sporulation efficiency. Three of the four “high” sporulation alleles are derived from the “low” sporulating strain. Two of these sporulation-related genes were verified through allele replacements. For RAS2, the causative variation was suggested to be a single nucleotide difference in the upstream region of the gene. This quantitative trait nucleotide accounts for sporulation variability among a set of ten closely related winery yeast strains. Our results provide a detailed view of genetic complexity in one “QTL region” that controls a quantitative trait and reports a single nucleotide polymorphism-trait association in wild strains. Moreover, these findings have implications on QTL identification in higher eukaryotes
Relationship of depression, disability, and family caregiver attitudes to the quality of life of Kuwaiti persons with multiple sclerosis: a controlled study
- Author
- Abdel W Awadalla
- AF Alshubaili
- AG Beiske
- AJ Bishop
- AK Olusina
- AS Al-Din
- Asmahan F Alshubaili
- Asser A Mabrouk
- AT Beck
- AW Awadalla
- AW Awadalla
- AW Awadalla
- AW Awadalla
- AW Awadalla
- B McKenzie
- CM Poser
- D Goleman
- D Raune
- F Patti
- F Patti
- F Sainfort
- FA Al-Turkait
- G Kobelt
- G Kobelt
- G Kobelt
- G Kobelt
- HL Ford
- IS Lobentanz
- IS Simone
- J Drulovic
- J Kurtzke
- JB Guarnaccia
- JF Helliwell
- JJ Newsom
- Jude U Ohaeri
- K Gottberg
- KA Ryan
- L Julian
- LJ Krisjanson
- M Aigner
- M Heinz
- M Iacoboni
- M Pugliatti
- MP Jensen
- MT Wallin
- MW Norvedt
- N Pfaffenberger
- O Lily
- P Ayatollahi
- S Ozakbas
- Secondary Progressive Efficacy Clinical Trial of Recombinant Interferon-beta -1a in MS (SPEC-TRIMS) Study Group
- SJ Pittock
- SM Skevington
- TE Sherman
- The Canadian Burden of illness Study Group
- V Casado
- V Janardhan
- Publication venue
- BioMed Central
- Publication date
- 01/01/2007
- Field of study
<p>Abstract</p> <p>Background</p> <p>Assessment of subjective quality of life (QOL) of persons with multiple sclerosis (MS) could facilitate the detection of psychosocial aspects of disease that may otherwise go unrecognized. The objectives of the study were to (i) compare the QOL ratings of relapsing remitting (RRMS) and progressive (PMS) types of MS with those of a general population group and the impression of their family caregivers; and (ii) assess the association of demographic, clinical, treatment, depression, and caregiver variables with patients' QOL.</p> <p>Methods</p> <p>Consecutive clinic attendees at the national neurology hospital were assessed with the 26 -item WHOQOL Instrument, Beck's Depression Inventory and Expanded Disability Scale. Caregivers rated their impression of patients' QOL and attitudes to patients' illness.</p> <p>Results</p> <p>The 170 patients (60 m, 109 f) consisted of 145(85.3%) with RRMS and 25 with PMS, aged 32.4(SD 8.8), age at onset 27.1(7.7), EDSS score 2.9 (1.8), and 76% were employed. The patients were predominantly dissatisfied with their life circumstances. The RRMS group had higher QOL domain scores (P < 0.001), and lower depression(P > 0.05) and disability (P < 0.0001) scores than the PMS group. Patients had significantly lower QOL scores than the control group (P < 0.001). Caregiver impression was significantly correlated with patients' ratings. Depression was the commonest significant covariate of QOL domains. When we controlled for depression and disability scores, differences between the two MS groups became significant for only one (out of 6) QOL domains. Patients who were younger, better educated, employed, felt less sick and with lesser side effects, had higher QOL. The predictors of patients' overall QOL were disability score, caregiver impression of patients' QOL, and caregiver fear of having MS.</p> <p>Conclusion</p> <p>Our data indicate that MS patients in stable condition and with social support can hope to have better QOL, if clinicians pay attention to depression, disability, the impact of side effects of treatment and family caregiver anxieties about the illness. The findings call for a regular program of psychosocial intervention in the clinical setting, to address these issues and provide caregiver education and supports, in order to enhance the quality of care.</p
Measurement of the cross section for inclusive isolated-photon production in pp collisions at √s=13TeV using the ATLAS detector
- Author
- Aaboud M
- Aad G
- Abbott B
- Abdinov O
- Abeloos B
- Abidi SH
- AbouZeid OS
- Abraham NL
- Abramowicz H
- Abreu H
- Abreu R
- Abulaiti Y
- Acharya BS
- Adachi S
- Adamczyk L
- Adelman J
- Adersberger M
- Adye T
- Affolder AA
- Afik Y
- Agatonovic-Jovin T
- Agheorghiesei C
- Aguilar-Saavedra JA
- Ahlen SP
- Ahmadov F
- Aielli G
- Akatsuka S
- Akerstedt H
- Akesson TPA
- Akilli E
- Akimov AV
- Alberghi GL
- Albert J
- Albicocco P
- Alconada Verzini MJ
- Alderweireldt SC
- Aleksa M
- Aleksandrov IN
- Alexa C
- Alexander G
- Alexopoulos T
- Alhroob M
- Ali B
- Aliev M
- Alimonti G
- Alison J
- Alkire SP
- Allbrooke BMM
- Allen BW
- Allport PP
- Aloisio A
- Alonso A
- Alonso F
- Alpigiani C
- Alshehri AA
- Alstaty MI
- Alvarez Piqueras D
- Alviggi MG
- Amadio BT
- Amelung C
- Amidei D
- Amor Dos Santos SP
- Amoroso S
- Amundsen G
- Anastopoulos C
- Ancu LS
- Andari N
- Andeen T
- Anders CF
- Anders JK
- Anderson KJ
- Andreazza A
- Andrei V
- Angelidakis S
- Angelozzi I
- Angerami A
- Anisenkov AV
- Anjos N
- Annovi A
- Antel C
- Antonelli M
- Antonov A
- Antrim DJ
- Anulli F
- Aoki M
- Arabidze G
- Arai Y
- Araque JP
- Araujo Ferraz V
- Araya ST
- Arce ATH
- Ardell RE
- Arduh FA
- Arguin J-F
- Argyropoulos S
- Arik M
- Armbruster AJ
- Armitage LJ
- Arnaez O
- Arnold H
- Arratia M
- Arslan O
- Artamonov A
- Artoni G
- Artz S
- Asai S
- Asbah N
- Ashkenazi A
- Asquith L
- Assamagan K
- Astalos R
- Astigarraga MEP
- Atkinson M
- Atlay NB
- Augsten K
- Avolio G
- Axen B
- Ayoub MK
- Azuelos G
- Baas AE
- Baca MJ
- Bachacou H
- Bachas K
- Backes M
- Bagnaia P
- Bahmani M
- Bahrasemani H
- Baines JT
- Bajic M
- Baker OK
- Bakker PJ
- Baldin EM
- Balek P
- Balli F
- Balunas WK
- Banas E
- Bandyopadhyay A
- Banerjee S
- Bannoura AAE
- Barajas CAC
- Barak L
- Barberio EL
- Barberis D
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- Barkeloo JT
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- Batley JR
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- Yildirim E
- Yildiz HD
- Yorita K
- Yoshihara K
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- Young CJS
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- Yusuff I
- Zabinski B
- Zacharis G
- Zaidan R
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- Zakharchuk N
- Zalieckas J
- Zaman A
- Zambito S
- Zanzi D
- Zeitnitz C
- Zemaityte G
- Zemla A
- Zeng JC
- Zeng Q
- Zenin O
- Zenis T
- Zerwas D
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- Zhang F
- Zhang G
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- Zhang J
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- Zhang P
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- Zhang X
- Zhang Y
- Zhang Z
- Zhao X
- Zhao Y
- Zhao Z
- Zhemchugov A
- Zhou B
- Zhou C
- Zhou L
- Zhou M
- Zhou M
- Zhou N
- Zhou Y
- Zhu CG
- Zhu H
- Zhu J
- Zhu Y
- Zhuang X
- Zhukov K
- Zibell A
- Zieminska D
- Zimine NI
- Zimmermann C
- Zimmermann S
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- Zinser M
- Ziolkowski M
- Zivkovic L
- Zobernig G
- Zoccoli A
- Zou R
- zur Nedden M
- Zwalinski L
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2017
- Field of study
Inclusive isolated-photon production in pp collisions at a centre-of-mass energy of 13TeVis studied with the ATLAS detector at the LHC using a data set with an integrated luminosity of 3.2fb−1. The cross section is measured as a function of the photon transverse energy above 125GeVin different regions of photon pseudorapidity. Next-to-leading-order perturbative QCD and Monte Carlo event-generator predictions are compared to the cross-section measurements and provide an adequate description of the data
Measurement of VH, H → b b ¯ production as a function of the vector-boson transverse momentum in 13 TeV pp collisions with the ATLAS detector
- Author
- Aaboud M
- Aad G
- Abbott B
- Abbott DC
- Abdinov O
- Abhayasinghe DK
- Abidi SH
- AbouZeid OS
- Abraham NL
- Abramowicz H
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- Acharya BS
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- Akesson TPA
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- Alberghi GL
- Alberich LC
- Albert J
- Alconada Verzini MJ
- Alderweireldt S
- Aleksa M
- Aleksandrov IN
- Alexa C
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- Bocchetta SS
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- Bogdanchikov AG
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- Buzykaev AR
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- Caforio D
- Cai H
- Cairo VMM
- Cakir O
- Calace N
- Calafiura P
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- Yallup DP
- Yamaguchi D
- Yamaguchi Y
- Yamamoto A
- Yamanaka T
- Yamane F
- Yamatani M
- Yamazaki T
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- Yoshihara K
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- Zabinski B
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- Zahreddine J
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- Zhemchugov A
- Zheng Z
- Zhong D
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- Zhulanov V
- Zieminska D
- Zimine NI
- Zimmermann S
- Zinonos Z
- Ziolkowski M
- Zivkovic L
- Zobernig G
- Zoccoli A
- Zoch K
- Zorbas TG
- Zou R
- Zu Theenhausen HM
- Zwalinski L
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2019
- Field of study
Cross-sections of associated production of a Higgs boson decaying into bottom-quark pairs and an electroweak gauge boson, W or Z, decaying into leptons are measured as a function of the gauge boson transverse momentum. The measurements are performed in kinematic fiducial volumes defined in the `simplified template cross-section' framework. The results are obtained using 79.8 fb-1 of proton-proton collisions recorded by the ATLAS detector at the Large Hadron Collider at a centre-of-mass energy of 13 TeV. All measurements are found to be in agreement with the Standard Model predictions, and limits are set on the parameters of an effective Lagrangian sensitive to modifications of the Higgs boson couplings to the electroweak gauge bosons
Global economic burden of unmet surgical need for appendicitis
- Author
- Aahlin E. K.
- Aamer A.
- Aaniana K.
- Ababneh A.
- Abaliksta T.
- Abantanga F.
- Abbas M.
- Abbasy J.
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- Abdallah E.
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- Publication venue
- Oxford University Press
- Publication date
- 01/01/2022
- Field of study
Background: There is a substantial gap in provision of adequate surgical care in many low-and middle-income countries. This study aimed to identify the economic burden of unmet surgical need for the common condition of appendicitis. Methods: Data on the incidence of appendicitis from 170 countries and two different approaches were used to estimate numbers of patients who do not receive surgery: as a fixed proportion of the total unmet surgical need per country (approach 1); and based on country income status (approach 2). Indirect costs with current levels of access and local quality, and those if quality were at the standards of high-income countries, were estimated. A human capital approach was applied, focusing on the economic burden resulting from premature death and absenteeism. Results: Excess mortality was 4185 per 100 000 cases of appendicitis using approach 1 and 3448 per 100 000 using approach 2. The economic burden of continuing current levels of access and local quality was US 92492millionusingapproach1and73 141 million using approach 2. The economic burden of not providing surgical care to the standards of high-income countries was 95004millionusingapproach1and75 666 million using approach 2. The largest share of these costs resulted from premature death (97.7 per cent) and lack of access (97.0 per cent) in contrast to lack of quality. Conclusion: For a comparatively non-complex emergency condition such as appendicitis, increasing access to care should be prioritized. Although improving quality of care should not be neglected, increasing provision of care at current standards could reduce societal costs substantially
Pooled analysis of WHO Surgical Safety Checklist use and mortality after emergency laparotomy
- Author
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- Amoah M
- Amoako J
- Amoako PT
- Amoako-Boateng M
- Amole I
- Amreia M
- Amreia M
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- Appeadu-Mensah W
- Appiah EK
- Aql S
- Aquilino F
- Arachchi PP
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- Arafa O
- Arafa S
- Arango MCM
- Arango MCM
- Aranzabal Durand SY
- Araujo R
- Arcudi C
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- Arenas A
- Arevalo Azmitia JR
- Arias Pacheco RD
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- Awad SA
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- Ayad S
- Ayandipo O
- Ayandipo OO
- Aydin MC
- Ayyar S
- Aziz DNA
- Aziz MRA
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- Azizeldine MG
- Azmitia Mendizabal CA
- Azodo IA
- Azzie G
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- Badr A
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- Balducci G
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- Baluch F
- Bamford R
- Bamicha A
- Bamicha A
- Banaitis VJ
- Bandi A
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- Bani-Sadar A
- Banipal GS
- Baraka H
- Barakat SAE
- Barendegere V
- Barker T
- Barkolias C
- Barmayehvar B
- Barnabas GN
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- Barrionuevo Ojeda RR
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- Barry J
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- Bassem M
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- Benons N
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- Bertuello I
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- Bezerra Morais PA
- Bezzina M
- Bhang A
- Bhangu A
- Bhangu A
- Bhargava A
- Bharj IS
- Bhat S
- Bhatnagar A
- Bhattacharya S
- Bhopal KF
- Bhopal KF
- Bianco F
- Bigaran A
- Billy M
- Bin Adnan A
- Bin Hasnan M
- Bin Ismail MJ
- Bin Mahamood A
- Birindelli A
- Birring A
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- Blacker S
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- Cecilia T
- Celik S
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- Cengiz Y
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- Chachulski W
- Chai C-A
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- Chambers A
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- Chan XW
- Chan Z
- Chandrakumar C
- Chang K
- Chang KY-C
- Chapman A
- Chapman SJ
- Charles A
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- Chen CY
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- Chen T-L
- Chenn R
- Cheong YJ
- Chetta N
- Cheung YHE
- Chew LS
- Chhabra S
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- Chidambaram S
- Chiesa D
- Chilton G
- Chin PX
- Chin YR
- Chiu S
- Chiu S
- Chiu SMY
- Choi J
- Choi P
- Chong BFHK
- Chong CL
- Chong CL
- Chong CL
- Chong CS
- Chong H-Y
- Chong HY
- Choudhry A
- Chow CYN
- Chowdhury A
- Chowdhury D
- Chu K
- Chun A
- Chun T
- Chung KJ
- Chung S
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- D'Amours S
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- Dar M
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- Dedey F
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- del Pilar Paucar A
- Delforge X
- Dell A
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- Deputy M
- Der Y
- Dervenis C
- Despotidis V
- Desta S
- Deutschmann P
- Devadasar GH
- Dharamshi HA
- Dhillon D
- Di Franco F
- Di Martino N
- Di Saverio S
- Di Saverio S
- Diab A
- Diaconescu B
- Diaconescu I-B
- Dias S
- Diaz Vico T
- Diaz-Jover P
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- Dick L
- Dickfos M
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- Dijan E
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- Din F
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- Dione Parreno-Sacdalan M
- Dissanayake T
- Djivoh F
- Domini E
- Domini E
- Donnelly P
- Donoghue D
- Dorani RMNR
- Dorisme A
- dos Santos DV
- Dossou F
- Doughan S
- Doughty J
- Dousset B
- Dragatas D
- Drake TM
- Drake TM
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- Driscoll A
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- du Plooy F
- Du Toit F
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- Duhoranenayo D
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- Ebrahim OS
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- El Dahab AA
- El Deen KN
- El Gendy A
- El Gendy NH
- El Halawany M
- El Jamassi A
- El Kashash A
- El Kholy A
- El Magd AA
- El Mesery S
- El Sayed GS
- El Sayed IM
- El Shoura Y
- El-badawy HA
- El-Dien KS
- El-Dien KS
- El-Din RA
- El-Din SA
- El-Gizawy E
- El-Hamouly AS
- El-Kashef H
- El-Latif NK
- El-Ma'doul AS
- El-Rabaa S
- El-Sagheer N
- El-Sawy A
- El-Sehily A
- El-Shahat NS
- El-Sheemy H
- El-Taher E
- Elabdin HZ
- Elashmawy M
- Elashry R
- Elazab A
- Elazayem AA
- Elazoul M
- Elbanby E
- Elbanby ES
- Elbatahgy A
- Elbe P
- Elbermawy M
- Elbisomy KH
- Eldafrawy M
- Eldamaty L
- Eldeeb AZ
- Eldeen EA
- Eldin MAB
- EldosoukyMohammed A
- Elebute O
- Elebute O
- Elena G
- Elfarargy A
- Elfeki H
- Elfeki H
- Elfiky M
- Elfil M
- Elfouly N
- Elfouly N
- Elfouly Y
- Elfouly Y
- Elgebaly A
- Elgendy AH
- Elgendy FI
- Elgheriany M
- Elhadad A
- Elhadary NM
- Elhadry S
- Elhalawany E
- Elhamouly S
- Elhelbawy MS
- Elhendawy A
- Elhendawy AOA
- Elhoseny G
- Elhusseiny AAE
- Elizabeth Lopez C
- Elkadsh I
- Elkady F
- Elkelany A
- Elkelany A
- Elkelany A
- Elkelany A
- Elkhadrawi M
- Elkhalek EA
- Elkholy A
- Elkholy SS
- Elkolaly SS
- Elkorashy AM
- Ellison Q
- Elmashala A
- Elmasry M
- Elmelegy R
- Elmihy S
- Elnagar A
- Elnajjar MA
- Elnemr AE
- Elrazek AA
- Elsabbagh N
- Elsameea AA
- Elsawahly DME
- Elsawy A
- Elsayed M
- Elsayed M
- Elsayed N
- Elsayed NAR
- Elsayed ZM
- Elsebaaye AO
- Elsehimy M
- Elsemelawy R
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- Elshafay AE
- Elshami M
- Elshanwany S
- Elsharkawy AA
- Elsheikh S
- Elsherbiney S
- Elsherbiny AS
- Elsherif FA
- Elshobary M
- Elsiddig M
- Elsobky S
- Elsorogy DEAA
- Elwaey A
- Elwakil H
- Elwan A
- Elwan A
- Elwy E
- Elzahed N
- Elzayat I
- Elzayat M
- Elzayyat I
- Elzowawi F
- Emadeldin D
- Emadeldin H
- Emara E
- Emile S
- Eng C
- English W
- Esam A
- Escalante Salas MDC
- Espin-Basany E
- Espinoza F
- Essam A
- Essam AA
- Essam M
- Essoun S
- Esteban E
- Estee MM
- Estupinian S
- Etchill E
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- Etienne S
- Etman M
- Etwire V
- Evajelista CV
- Evans D
- Evans E
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- Eyssartier E
- Ezzat E
- Ezzat T
- Faboya O
- Faccincani R
- Fadel A
- Fahiem A
- Fahim M
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- Falzon M
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- Farag S
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- Faraz A
- Fares M
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- Farhangmehr N
- Farinella E
- Farmakis K
- Farooq T
- Farouk SAM
- Farquharson A
- Farrugia A
- Farrugia A
- Faruq A
- Fathy AM
- Fattah AA
- Fatuga A
- Faturoti O
- Faturoti O
- Faure A
- Fautz T
- Favero A
- Fawzy A
- Feidantsis T
- Felipe CO
- Fergany A
- Fergusson SJ
- Fergusson SJ
- Fergusson SJ
- Fergusson SJ
- Fermani C
- Fermani CG
- Fernandes C
- Fernandez C
- Fernandez-Bueno F
- Fernandez-Vega L
- Ferousis C
- Ferrero E
- Fievet L
- Filatau A
- Findlay-Cooper K
- Firdouse M
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- Firwana A
- Fitsum A
- Fitzgerald JE
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- Florez Farfan ES
- Foco M
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- Foo CC
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- Forno W
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- Fourcade L
- Fowler AJ
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- Frade F
- Fraga GP
- Francisco Roxas M
- Franco H
- Francois P
- Francois-Coridon H
- Francone E
- Freitas AV
- Frey D
- Frisk B
- Fuentes-Rivera L
- Fujii F
- Furqan MM
- Gaafar S
- Gaarder T
- Gad A
- Gad MO
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- Gadhvi V
- Gado A
- Gaignard E
- Gaignard E
- Gaizauskas V
- Gala T
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- Galiqi G
- Galleano R
- Gallo G
- Galloway S
- Galvez CP
- Gamal D
- Gamal E
- Gamal H
- Gamal S
- Gamaly E
- Gamil D
- Gan C
- Gan YY
- Gani MA
- Garaycochea O
- Garcia Bernardo C
- Garcia Florez LJ
- Garcia Septiem J
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- Garland A
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- Gaujoux S
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- Gemeah M
- Gemenetzis G
- Gemenetzis G
- George R
- Germanos S
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- Gerosa A
- Gerosa A
- Geuoshy A
- Ghaben A
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- Giavarini L
- Giglio MC
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- Gkiokas G
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- Glover TE
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- Glynn M
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- Goh W
- Gohar ME-SAM
- Gokani S
- Goldin E
- Golding D
- Gomaa A
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- Gonzales Montejo MS
- Gonzales Stuva JP
- Gonzalez M
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- Grella MG
- Gribauskaite J
- Griffiths E
- Griffiths E
- Griffiths M
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- Grisin E
- Grizhja B
- Grobler DC
- Grosos C
- Grossart C
- Gubeli A
- Gudal A
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- Guevara Torres S
- Guevara R
- Guglielmo V
- Gui D
- Gul E
- Gulbinas A
- Gulcicek OB
- Gulielmi A
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- Gunawan R
- Guner A
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- Gyamfi FE
- Gyanchandani N
- Gyedu A
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- Hache-Marliere M
- Haddad N
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- Hafiz S
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- Hagar A
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- Hajeh H
- Hakim H
- Halhouli O
- Halhouli O
- Halicioglu I
- Hall E
- Hall N
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- Hall TF
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- Hamarshi A
- Hamasaki Hamaguchi JL
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- Hashad E
- Hasheminia A
- Hashim A
- Hashish A
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- Haslegrave A
- Hassaan A
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- Hassan ATA
- Hassan I
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- Havemann I
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- Hemmila M
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- Herikstad R
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- Herrera Puma CM
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- Publication venue
- Publication date
- 15/10/2018
- Field of study
Background The World Health Organization (WHO) Surgical Safety Checklist has fostered safe practice for 10 years, yet its place in emergency surgery has not been assessed on a global scale. The aim of this study was to evaluate reported checklist use in emergency settings and examine the relationship with perioperative mortality in patients who had emergency laparotomy. Methods In two multinational cohort studies, adults undergoing emergency laparotomy were compared with those having elective gastrointestinal surgery. Relationships between reported checklist use and mortality were determined using multivariable logistic regression and bootstrapped simulation. Results Of 12 296 patients included from 76 countries, 4843 underwent emergency laparotomy. After adjusting for patient and disease factors, checklist use before emergency laparotomy was more common in countries with a high Human Development Index (HDI) (2455 of 2741, 89.6 per cent) compared with that in countries with a middle (753 of 1242, 60.6 per cent; odds ratio (OR) 0.17, 95 per cent c.i. 0.14 to 0.21, P <0001) or low (363 of 860, 422 per cent; OR 008, 007 to 010, P <0.001) HDI. Checklist use was less common in elective surgery than for emergency laparotomy in high-HDI countries (risk difference -94 (95 per cent c.i. -11.9 to -6.9) per cent; P <0001), but the relationship was reversed in low-HDI countries (+121 (+7.0 to +173) per cent; P <0001). In multivariable models, checklist use was associated with a lower 30-day perioperative mortality (OR 0.60, 0.50 to 073; P <0.001). The greatest absolute benefit was seen for emergency surgery in low- and middle-HDI countries. Conclusion Checklist use in emergency laparotomy was associated with a significantly lower perioperative mortality rate. Checklist use in low-HDI countries was half that in high-HDI countries.Peer reviewe
Observation of Electroweak Production of a Same-Sign W Boson Pair in Association with Two Jets in pp Collisions root s=13 TeV with the ATLAS Detector
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- Zivkovic L
- Zobernig G
- Zoccoli A
- Zoch K
- Zorbas TG
- Zou R
- Zu Theenhausen HM
- Zur Nedden M
- Zwalinski L
- Publication venue
- AMER PHYSICAL SOC
- Publication date
- 18/10/2019
- Field of study
This Letter presents the observation and measurement of electroweak production of a same-sign
W
boson pair in association with two jets using
36.1
fb
−
1
of proton-proton collision data recorded at a center-of-mass energy of
√
s
=
13
TeV
by the ATLAS detector at the Large Hadron Collider. The analysis is performed in the detector fiducial phase-space region, defined by the presence of two same-sign leptons, electron or muon, and at least two jets with a large invariant mass and rapidity difference. A total of 122 candidate events are observed for a background expectation of
69
±
7
events, corresponding to an observed signal significance of 6.5 standard deviations. The measured fiducial signal cross section is
σ
fid
=
2.89
+
0.51
−
0.48
(
stat
)
+
0.29
−
0.28
(
syst
)
fb
Measurement of Azimuthal Anisotropy of Muons from Charm and Bottom Hadrons in pp Collisions at √s = 13 TeV with the ATLAS Detector
- Author
- Aaboud M
- Aad G
- Abbott B
- Abdinov O
- Abeloos B
- Abhayasinghe DK
- Abidi SH
- AbouZeid OS
- Abraham NL
- Abramowicz H
- Abreu H
- Abulaiti Y
- Acharya BS
- Adachi S
- Adamczyk L
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- Adersberger M
- Adiguzel A
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- Agheorghiesei C
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- Ahmadov F
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- Publication venue
- AMER PHYSICAL SOC
- Publication date
- 28/02/2020
- Field of study
The elliptic flow of muons from the decay of charm and bottom hadrons is measured in
p
p
collisions at
√
s
=
13
TeV
using a data sample with an integrated luminosity of
150
pb
−
1
recorded by the ATLAS detector at the LHC. The muons from heavy-flavor decay are separated from light-hadron decay muons using momentum imbalance between the tracking and muon spectrometers. The heavy-flavor decay muons are further separated into those from charm decay and those from bottom decay using the distance-of-closest-approach to the collision vertex. The measurement is performed for muons in the transverse momentum range 4–7 GeV and pseudorapidity range
|
η
|
<
2.4
. A significant nonzero elliptic anisotropy coefficient
v
2
is observed for muons from charm decays, while the
v
2
value for muons from bottom decays is consistent with zero within uncertainties
Search for squarks and gluinos in final states with jets and missing transverse momentum using 139 fb−1 of s√ = 13 TeV pp collision data with the ATLAS detector
- Author
- Aaboud M
- Aad G
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- Abdinov O
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- Abhayasinghe DK
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- Zanzi D
- Zaripovas DR
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- Zemaityte G
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- Zhemchugov A
- Zhou B
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- Zhulanov V
- Zibell A
- Zieminska D
- Zimine NI
- Zimmermann S
- Zinonos Z
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- Publication venue
- 'Springer Fachmedien Wiesbaden GmbH'
- Publication date
- 17/02/2021
- Field of study
A search for the supersymmetric partners of quarks and gluons (squarks and gluinos) in final states containing jets and missing transverse momentum, but no electrons or muons, is presented. The data used in this search were recorded by the ATLAS experiment in proton-proton collisions at a centre-of-mass energy of s√ = 13 TeV during Run 2 of the Large Hadron Collider, corresponding to an integrated luminosity of 139 fb−1. The results are interpreted in the context of various R-parity-conserving models where squarks and gluinos are produced in pairs or in association and a neutralino is the lightest supersymmetric particle. An exclusion limit at the 95% confidence level on the mass of the gluino is set at 2.30 TeV for a simplified model containing only a gluino and the lightest neutralino, assuming the latter is massless. For a simplified model involving the strong production of mass-degenerate first- and second-generation squarks, squark masses below 1.85 TeV are excluded if the lightest neutralino is massless. These limits extend substantially beyond the region of supersymmetric parameter space excluded previously by similar searches with the ATLAS detector
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