8 research outputs found
Climate Justice Charter
The latest news from our planet is threatening: climate change, pollution, forest loss, species extinctions. All these words are frightening and there is no sign of improvement. Simple logic leads to the conclusion that humanity has to react, for its own survival. But at the scale of a human being, it is less obvious. Organizing oneâs daily life in order to preserve the environment implies self-questioning, changing habits, sacrificing some comfort. In one word, it is an effort. Then, what justifies such an effort? The personal choice to act in order to preserve our environment is often made by simple altruism. This choice is based on our love for other human beings: our love for the others grounds our effort. Our moral values, our ethical reflections and our religious beliefs are the deep core of these choices. âThis is my commandment, that you love one another as I have loved you.â (John 15.12 NRSV). This Charter shows the moral and religious values that can help us react regarding the current environmental crisis and it
should empower us to transcend the ideas of effort and sacrifice in order to consider the respect of the shared house, in a prophetic fulfillment of the being
Advanced learning on Li-ion rechargeable battery safety from detailed examination of component/material behavior under thermal stress
Metal ion-tetracycline interactions in biological fluids. Part 3. Formation of mixed-metal ternary complexes of tetracycline, oxytetracycline, doxycycline and minocycline with calcium and magnesium, and their involvement in the bioavailability of these antibiotics in blood plasma
Doxycycline is an NF-ÎșB inhibitor that induces apoptotic cell death in malignant T-cells
Cutaneous T-cell Lymphoma (CTCL) is a rare non-Hodgkin\u27s lymphoma that can affect the skin, blood, and lymph nodes, and can metastasize at late stages. Novel therapies that target all affected disease compartments and provide longer lasting responses while being safe are needed. One potential therapeutic target is NF-ÎșB, a regulator of immune responses and an important participant in carcinogenesis and cancer progression. As a transcription factor, NF-ÎșB targets genes that promote cell proliferation and survival. Constitutive or aberrant activation of NF-ÎșB is encountered in many types of cancer, including CTCL.Recently, while analyzing gene-expression profiles of a variety of small molecule compounds that target NF-ÎșB, we discovered the tetracycline family of antibiotics, including doxycycline, to be potent inhibitors of the NF-ÎșB pathway. Doxycycline is well-tolerated, safe, and inexpensive; and is commonly used as an antibiotic and anti-inflammatory for the treatment a multitude of medical conditions.In our current study, we show that doxycycline induces apoptosis in a dose dependent manner in multiple different cell lines from patients with the two most common subtypes of CTCL, Mycosis Fungoides (MF) and SĂ©zary Syndrome (SS). Similar results were found using primary CD4+ T cells from a patient with SS. Doxycycline inhibits TNF induced NF-ÎșB activation and reduces expression of NF-ÎșB dependent anti-apoptotic proteins, such as BCL2α. Furthermore, we have identified that doxycycline induces apoptosis through reactive oxygen species