30-y follow-up of a Pu/Am inhalation case

In 1983, a young man inhaled accidentally a large amount of plutonium and americium. This case was carefully followed until 2013. Since no decorporation measures had been taken, the undisturbed metabolism of Pu and Am can be derived from the data. First objective was to determine the amount of inhaled radionuclides and to estimate committed effective dose. In vivo and excretion measurements started immediately after the inhalation, and for quality assurance, all types of measurements were performed by different labs in Europe and the USA. After dose assessment by various international groups were completed, the measurements were continued to produce scientific data for model validation. The data have been analysed here to estimate lung absorption parameter values for the inhaled plutonium and americium oxide using the proposed new ICRP Human Respiratory Tract Model. As supplement to the biokinetic modelling, biological data from three different cytogenetic markers have been added. The estimated committed effective dose is in the order of 1 Sv. The subject is 30 y after the inhalation, of good health, according to a recent medical check-u

Identification of 12 new susceptibility loci for different histotypes of epithelial ovarian cancer.

To identify common alleles associated with different histotypes of epithelial ovarian cancer (EOC), we pooled data from multiple genome-wide genotyping projects totaling 25,509 EOC cases and 40,941 controls. We identified nine new susceptibility loci for different EOC histotypes: six for serous EOC histotypes (3q28, 4q32.3, 8q21.11, 10q24.33, 18q11.2 and 22q12.1), two for mucinous EOC (3q22.3 and 9q31.1) and one for endometrioid EOC (5q12.3). We then performed meta-analysis on the results for high-grade serous ovarian cancer with the results from analysis of 31,448 BRCA1 and BRCA2 mutation carriers, including 3,887 mutation carriers with EOC. This identified three additional susceptibility loci at 2q13, 8q24.1 and 12q24.31. Integrated analyses of genes and regulatory biofeatures at each locus predicted candidate susceptibility genes, including OBFC1, a new candidate susceptibility gene for low-grade and borderline serous EOC

Discovery of common and rare genetic risk variants for colorectal cancer.

To further dissect the genetic architecture of colorectal cancer (CRC), we performed whole-genome sequencing of 1,439 cases and 720 controls, imputed discovered sequence variants and Haplotype Reference Consortium panel variants into genome-wide association study data, and tested for association in 34,869 cases and 29,051 controls. Findings were followed up in an additional 23,262 cases and 38,296 controls. We discovered a strongly protective 0.3% frequency variant signal at CHD1. In a combined meta-analysis of 125,478 individuals, we identified 40 new independent signals at P < 5 × 10-8, bringing the number of known independent signals for CRC to ~100. New signals implicate lower-frequency variants, Krüppel-like factors, Hedgehog signaling, Hippo-YAP signaling, long noncoding RNAs and somatic drivers, and support a role for immune function. Heritability analyses suggest that CRC risk is highly polygenic, and larger, more comprehensive studies enabling rare variant analysis will improve understanding of biology underlying this risk and influence personalized screening strategies and drug development.Goncalo R Abecasis has received compensation from 23andMe and Helix. He is currently an employee of Regeneron Pharmaceuticals. Heather Hampel performs collaborative research with Ambry Genetics, InVitae Genetics, and Myriad Genetic Laboratories, Inc., is on the scientific advisory board for InVitae Genetics and Genome Medical, and has stock in Genome Medical. Rachel Pearlman has participated in collaborative funded research with Myriad Genetics Laboratories and Invitae Genetics but has no financial competitive interest

The Rise and Fall of Classical Thebes and its Sacred Band

The huge role played by Thebes in shaping 4th-century BC Greece has been obscured by Xenophon, who hated the Thebans and did his best to exclude them from Hellenica, his history of his own times. Xenophon never spoke of the Theban Sacred Band, an infantry corps made up of male lovers, leading one recent scholar to claim they never existed. Thanks to evidence from Plutarch and the excavation of the Band\u27s mass grave—recorded in drawings only recently uncovered—we can restore some of the missing pieces of Thebes\u27s brief term as superpower of Greece.https://pdxscholar.library.pdx.edu/foh_events/1000/thumbnail.jp

New Developments in Interactive Products: When the World Talks Back … Connecting People and Things

Presented on September 27, 2018 from 11:00 a.m. to 12:00 p.m. in the Georgia Tech Architecture Library, Room 214.College of Design Research Forum: New Developments in Interactive ProductsJim Budd is a Professor and Chair in the School of Industrial Design, Georgia Tech.Noah Posner is a Research Scientist in the IMAGINE Lab, Center for Spatial Planning Analytics and Visualization, Georgia Tech.Stuart Romm is a Professor of Practice in the School of Architecture, Georgia Tech.Wei Wang is an Assistant Professor in the School of Industrial Design, Georgia Tech.Runtime: 61:11 minutesOver the past 10 to 15 years the evolution of smart, sensor-based products and systems has reshaped the way we interact with each other and the world around us. This Research Forum will compare a snapshot from the past with new initiatives today that connect us with the products around us, the buildings we inhabit, and the cars we drive along with speculation of where we might be headed tomorrow