Free Energy Barrier for Electric Field Driven Polymer Entry into Nanoscale Channels

Free energy barrier for entry of a charged polymer into a nanoscale channel by a driving electric field is studied theoretically and using molecular dynamics simulations. Dependence of the barrier height on the polymer length, the driving field strength, and the channel entrance geometry is investigated. Squeezing effect of the electric field on the polymer before its entry to the channel is taken into account. It is shown that lateral confinement of the polymer prior to its entry changes the polymer length dependence of the barrier height noticeably. Our theory and simulation results are in good agreement and reasonably describe related experimental data

Don’t Stand By, Stand Up: A Peer Group Anti-Bullying Intervention to Increase Pro-Defending Attitudes and Behaviour in Students that Witness Bullying

Psychological research into bullying has highlighted the importance of considering the role of bystanders within this complex social interaction (see literature review). The aim of this paper was to apply this research to develop an anti-bullying intervention programme that increases pro-defending attitudes and behaviour, and consequently reduces bullying. The methodology was a design experiment; in this first iteration, the intervention programme was designed, implemented, and evaluated in collaboration with staff and students at a secondary school. Data were collected using a mixed methods approach via questionnaires, focus groups, an interview, and observation. The results showed that there was no significant difference in prevalence estimates of defending or bullying pre and post intervention. However, two thirds of participants reported that their attitudes and behaviour had become more supportive of defending victims since the intervention. Qualitative data revealed a diversity of perspectives regarding the effects and value of the programme. A model outlining factors that influence decisions to defend a victim of bullying was developed from the results and previous literature. The findings from this paper were used to inform modifications to the design of the intervention programme for implementation in the second iteration in paper 2

Ancient Egypt 1923 Part 3

Part 3 of the 1923 Ancient Egypt books. Contents include types of early scarabs, the Ka in Egypt and Arabia, supports of Pylon flagstaves, Pithom and Raamses, and current fallacies about history.https://knowledge.e.southern.edu/kweeks_coll/1024/thumbnail.jp

Sermon Occasioned by the Assassination of President Lincoln: Delivered April 16, 1865 in First Presbyterian Church of Paterson, N.J.

Sermond delivered by W. H. Hornblower at the First Presbyterian Church, Patterson, N.J. on the assassination of President Lincoln, April 16, 1865.https://scholarsjunction.msstate.edu/fvw-pamphlets/1512/thumbnail.jp

Self-energy limited ion transport in sub-nanometer channels

The current-voltage characteristics of the alpha-Hemolysin protein pore during the passage of single-stranded DNA under varying ionic strength, C, are studied experimentally. We observe strong blockage of the current, weak super-linear growth of the current as a function of voltage, and a minimum of the current as a function of C. These observations are interpreted as the result of the ion electrostatic self-energy barrier originating from the large difference in the dielectric constants of water and the lipid bilayer. The dependence of DNA capture rate on C also agrees with our model.Comment: more experimental material is added. 4 pages, 7 figure