79 research outputs found
Magnetic Field Amplification in Galaxy Clusters and its Simulation
- Author
- A. Bauer
- A. Beresnyak
- A. Beresnyak
- A. Bonafede
- A. Bonafede
- A. Bonafede
- A. Bonafede
- A. Brandenburg
- A. Brandenburg
- A. Dedner
- A. Finoguenov
- A. Kolmogorov
- A. Lazarian
- A. Lazarian
- A. Maier
- A. Marcowith
- A. Neronov
- A. Ruzmaikin
- A. Schekochihin
- A. Schekochihin
- A. Stroe
- A. Stroe
- A. Vikhlinin
- A. Vladimirov
- A.A. Schekochihin
- A.A. Schekochihin
- A.A. Schekochihin
- A.A. Schekochihin
- A.A. Schekochihin
- A.A. Schekochihin
- A.A. Vikhlinin
- A.D. Chernin
- A.E. Broderick
- A.E. Evrard
- A.G. Kritsuk
- A.M. Beck
- A.M. Beck
- A.M. Beck
- A.M. Beck
- A.M. Bykov
- A.M. Bykov
- A.M. Bykov
- A.N. Kolmogorov
- A.P. Kazantsev
- A.R. Bell
- B. Dennison
- B. Reville
- B. Reville
- B.E. Robertson
- B.M. Gaensler
- C. Caprini
- C. Federrath
- C. Federrath
- C. Federrath
- C. Federrath
- C. Ferrari
- C. Gheller
- C. Pfrommer
- C. Pfrommer
- C. Pfrommer
- C. Vogt
- C.L. Dobbs
- C.L. Sarazin
- C.L. Sarazin
- C.L. Sarazin
- D. Caprioli
- D. Caprioli
- D. Caprioli
- D. Lee
- D. Nagai
- D. Ryu
- D. Ryu
- D. Ryu
- D. Wittor
- D. Wittor
- D.H. Porter
- D.J. Price
- D.J. Price
- D.N. Hoang
- D.R.G. Schleicher
- D.R.G. Schleicher
- D.S. Balsara
- D.S. Young De
- E. Churazov
- E. Parizot
- E. Roediger
- E. Roediger
- E. Zinger
- E.R. Harrison
- E.T. Lau
- F. Aharonian
- F. Fraschetti
- F. Govoni
- F. Govoni
- F. Guo
- F. Guo
- F. Marinacci
- F. Marinacci
- F. Marinacci
- F. Miniati
- F. Miniati
- F. Miniati
- F. Miniati
- F. Miniati
- F. Mogavero
- F. Rincon
- F. Vazza
- F. Vazza
- F. Vazza
- F. Vazza
- F. Vazza
- F. Vazza
- F. Vazza
- F. Vazza
- F. Zandanel
- F.A. Stasyszyn
- F.J. Sánchez-Salcedo
- F.N. Owen
- G. Brunetti
- G. Brunetti
- G. Brunetti
- G. Brunetti
- G. Brunetti
- G. Brunetti
- G.K. Batchelor
- G.M. Voit
- G.R. Burbidge
- H. Alfvén
- H. Böhringer
- H. Chen
- H. Kang
- H. Xu
- H. Xu
- H.J. Völk
- I. Butsky
- I. Zhuravleva
- I.B. Zeldovich
- J. Binney
- J. Cho
- J. Donnert
- J. Donnert
- J. Donnert
- J. Donnert
- J. Giacalone
- J. Meinecke
- J. Roland
- J. Schober
- J. Wiener
- J. Wiener
- J. ZuHone
- J.A. Zuhone
- J.A. ZuHone
- J.A. ZuHone
- J.A. ZuHone
- J.A. ZuHone
- J.D. Barrow
- J.M. Burgers
- J.M.F. Donnert
- J.M.F. Donnert
- J.O. Burns
- K. Dolag
- K. Dolag
- K. Dolag
- K. Dolag
- K. Dolag
- K. Dolag
- K. Dolag
- K. Dolag
- K. Dolag
- K. Dolag
- K. Dolag
- K. Dolag
- K. Nakazawa
- K. Nelson
- K. Rajpurohit
- K. Roettiger
- K. Roettiger
- K. Roettiger
- K. Subramanian
- K. Subramanian
- K. Waagan
- L. Biermann
- L. Campanelli
- L. Iapichino
- L. Iapichino
- L. Iapichino
- L. Spitzer
- L.D. Landau
- L.D. Shaw
- L.J. Dursi
- L.J. Dursi
- L.M. Widrow
- L.O. Drury
- M. Ackermann
- M. Brüggen
- M. Brüggen
- M. Brüggen
- M. Brüggen
- M. Brüggen
- M. Gaspari
- M. Gendron-Marsolais
- M. Langer
- M. Lyutikov
- M. Markevitch
- M. Rieder
- M. Ruszkowski
- M. Ruszkowski
- M. Takizawa
- M.A. Latif
- M.A. Malkov
- M.A. Riquelme
- M.A. Riquelme
- M.A.G. Willson
- M.S. Turner
- M.W. Kunz
- M.W. Kunz
- N. Asai
- N. Asai
- N. Asai
- N. Battaglia
- N. Werner
- N.E.L. Haugen
- N.E.L. Haugen
- N.L. Mitchell
- O. Goldshmidt
- P. Goldreich
- P. Kuchar
- P. Mazzotta
- P. Schuecker
- P. Slane
- P. Trivedi
- P.A. Thomas
- P.A.R. Ade
- P.F. Hopkins
- P.F. Hopkins
- P.M. Ricker
- P.P. Kronberg
- R. Beck
- R. Durrer
- R. Khatri
- R. Pakmor
- R. Pakmor
- R. Santos-Lima
- R. Santos-Lima
- R. Schlickeiser
- R. Taylor
- R. Valdarnini
- R.A. Laing
- R.H. Kraichnan
- R.M. Kulsrud
- R.M. Kulsrud
- R.M. Kulsrud
- R.P. Kraft
- S. Bertone
- S. Borgani
- S. Giacintucci
- S. Giacintucci
- S. Giacintucci
- S. Jacob
- S. Jacob
- S. Ji
- S. Li
- S. Martin-Alvarez
- S. Melville
- S. Paul
- S. Planelles
- S. Planelles
- S. Schindler
- S. Sur
- S.A. Walker
- S.G. Lucek
- S.I. Vaĭnshteĭn
- S.P. Reynolds
- S.R. Furlanetto
- S.W. Skillman
- T. Enßlin
- T. Inoue
- T. Kahniashvili
- T. Kahniashvili
- T. Kahniashvili
- T. Naab
- T. Sano
- T.A. Enßlin
- T.A. Gardiner
- T.C. Arlen
- T.S. Tricco
- T.W. Jones
- T.W. Shimwell
- U. Keshet
- U. Klein
- V. Springel
- V. Vacca
- V. Vacca
- V. Yakhot
- V.B. Semikoz
- V.N. Zirakashvili
- W. Chen
- W. Dobler
- W. Jaffe
- W. Schmidt
- X. Shi
- X. Shi
- X. Shi
- X.N. Bai
- Y. Birnboim
- Y. Dubois
- Y. Dubois
- Y. Ichinohe
- Y. Su
- Y.B. Zel’dovich
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2018
- Field of study
We review the present theoretical and numerical understanding of magnetic
field amplification in cosmic large-scale structure, on length scales of galaxy
clusters and beyond. Structure formation drives compression and turbulence,
which amplify tiny magnetic seed fields to the microGauss values that are
observed in the intracluster medium. This process is intimately connected to
the properties of turbulence and the microphysics of the intra-cluster medium.
Additional roles are played by merger induced shocks that sweep through the
intra-cluster medium and motions induced by sloshing cool cores. The accurate
simulation of magnetic field amplification in clusters still poses a serious
challenge for simulations of cosmological structure formation. We review the
current literature on cosmological simulations that include magnetic fields and
outline theoretical as well as numerical challenges.Comment: 60 pages, 19 Figure
CpG-ODN and MPLA Prevent Mortality in a Murine Model of Post-Hemorrhage-Staphyloccocus aureus Pneumonia
- Author
- A Ouabed
- A Robinson
- Antoine Roquilly
- AS Czaja
- B Pulendran
- BC Esrig
- C Marie
- CD Mathers
- Corinne Lejus
- CT Damsgaard
- Cédric Jacqueline
- D Boutoille
- D Henrich
- D Lepelletier
- DM Klinman
- E Abraham
- F Pene
- G Papia
- G Plitas
- GC Patton
- Gilles Potel
- GW Bandiera
- H Kanzler
- H Poehlmann
- H Ueno
- H Weighardt
- J Banchereau
- Jean Pierre Segain
- Jocelyne Caillon
- JY Kim
- K Agbaht
- K Asehnoune
- K Asehnoune
- KA Fitzgerald
- Karim Asehnoune
- KJ Livak
- Laetitia Gautreau
- LJ Magnotti
- M Adib-Conquy
- M Adib-Conquy
- M Ditschkowski
- M Keel
- M Merad
- M Salio
- MD Rincon-Ferrari
- MJ Hershman
- N Safdar
- NJ Megjugorac
- Olivier Neyrolles
- Pierre de Coppet
- R Bronchard
- R Medzhitov
- R Thibault
- RN Stephan
- Régis Josien
- SB Flohe
- SG Muehlstedt
- T Kawasaki
- TM Osborn
- V Mata-Haro
- Véronique Sebille
- WG Cheadle
- YJ Liu
- Z Spolarics
- Publication venue
- Public Library of Science
- Publication date
- 01/01/2010
- Field of study
Infections are the most frequent cause of complications in trauma patients. Post-traumatic immune suppression (IS) exposes patients to pneumonia (PN). The main pathogen involved in PN is Methicillin Susceptible Staphylococcus aureus (MSSA). Dendritic cells () may be centrally involved in the IS. We assessed the consequences of hemorrhage on pneumonia outcomes and investigated its consequences on DCs functions. A murine model of hemorrhagic shock with a subsequent MSSA pneumonia was used. Hemorrhage decreased the survival rate of infected mice, increased systemic dissemination of sepsis and worsened inflammatory lung lesions. The mRNA expression of Tumor Necrosis Factor-alpha (TNF-α), Interferon-beta (IFN-β) and Interleukin (IL)-12p40 were mitigated for hemorrhaged-mice. The effects of hemorrhage on subsequent PN were apparent on the pDCs phenotype (reduced MHC class II, CD80, and CD86 molecule membrane expression). In addition, hemorrhage dramatically decreased CD8+ cDCs- and CD8- cDCs-induced allogeneic T-cell proliferation during PN compared with mice that did not undergo hemorrhage. In conclusion, hemorrhage increased morbidity and mortality associated with PN; induced severe phenotypic disturbances of the pDCs subset and functional alterations of the cDCs subset. After hemorrhage, a preventive treatment with CpG-ODN or Monophosphoryl Lipid A increased transcriptional activity in DCs (TNF-α, IFN-β and IL-12p40) and decreased mortality of post-hemorrhage MSSA pneumonia
Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)
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- Abdellatif M.
- Abdoli A.
- Abel S.
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- Adamopoulos I. E.
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- Adornetto A.
- Aflaki E.
- Agam G.
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- Al-Abd A. M.
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- Al-Gharaibeh A.
- Alaoui-Jamali M. A.
- Alberti S.
- Alcocer-Gomez E.
- Alessandri C.
- Ali M.
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- Publication venue
- 'Informa UK Limited'
- Publication date
- 01/01/2021
- Field of study
Effects of alirocumab on types of myocardial infarction: insights from the ODYSSEY OUTCOMES trial
- Author
- Abbas J
- Abbate A
- Abdullakutty J
- Abhyanakar AD
- Aboyans V
- Abrantes JAM
- Abu-Fadel M
- Acevedo M
- Adamkova V
- Adhyapak S
- Agarwal H
- Aggarwal R
- Aggarwal RK
- Aguirre A
- Ahmed H
- Ahremark U
- Ahuad Guerrero RA
- Aidar Ayoub JC
- Airaksinen JK
- Aitken D
- Akatova E
- Akhter F
- Ako J
- Akright L
- Akyea-Djamson A
- Al Joundi T
- Al-Windy NYY
- Alan D
- Alcocer Gamba MA
- Alexander JH
- Alexander K
- Alexandru TM
- Alings M
- Alonso Martin JJ
- Alvarisqueta AF
- Alves De Lima AE
- Amarasekera S
- Amarasena N
- Amir O
- Amlani M
- Amosova E
- Amuchastegui M
- Andersen K
- Andersen R
- Anderson J
- Ando K
- Angel Hominal M
- Annam S
- Anscombe R
- Apostolovic SR
- Appel K-F
- Arandjelovic A
- Araneda G
- Arango Benecke JL
- Arbel Y
- Arif I
- Armaganijan L
- Arroyo JAC
- Arstall MA
- Asanin MR
- Atar S
- Athyros V
- Auguadro C
- Ayala CAC
- Aylward PE
- Azizad MM
- Bagai A
- Bagriy A
- Bahit MC
- Bai F
- Balaguer Recena J
- Baldari D
- Balinovac J
- Ball E
- Bang LE
- Banuru S
- Barakovic F
- Baranov E
- Baranova E
- Barbarash OL
- Barbato E
- Barna OM
- Barone-Rochette G
- Barr C
- Barrucco R
- Bartels GL
- Bashir R
- Basson MMDV
- Bastos JM
- Bata I
- Batushkin V
- Bayat J
- Bayram Llamas EA
- Bayron C
- Beauloye C
- Bednarski J
- Behrens S
- Belhassane A
- Benedicto A
- Bengus CM
- Benov HO
- Berger R
- Berglund S
- Berk M
- Berland J
- Berli MA
- Berlowitz M
- Berman B
- Bernan A
- Berti S
- Bhagwat A
- Bhagwat R
- Bhansali P
- Bhatt DL
- Binder R
- Birchem J
- Bittner VA
- Blicharski T
- Blok T
- Blumberg EDS
- Boccara F
- Bodanese LC
- Bodi Peris V
- Boecker D
- Bojovski S
- Bokarev I
- Bokern MJJA
- Bonfanti AJC
- Bono JOE
- Bordonava AP
- Borse R
- Bortnick A
- Bos RJ
- Botas Rodriguez J
- Botelho A
- Botelho RV
- Botia DCL
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- Bourgeois R
- Brabham D
- Braganza D
- Braun-Dullaeus R
- Breedveld RW
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- Brodison A
- Bronzwaer PNA
- Brueren BRG
- Bruguera Cortada J
- Budaj A
- Bugan V
- Busmane A
- Bustamante Labarta MH
- Busz-Papiez B
- Butler R
- Bystryk L
- Caccavo A
- Caime GD
- Calabro P
- Camprubi Potau M
- Camsari A
- Caraco Y
- Carey C
- Carlson E
- Carnero GS
- Carranza Madrigal J
- Carrillo Calvillo J
- Carroll PA
- Cartasegna LR
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- Caruso OC
- Cassimjee S
- Castadot M
- Cavallini C
- Cequier Fillat AR
- Cerqueira MJAG
- Cestari HG
- Cevc M
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- Chae I-H
- Chaitman B
- Chalavarya G
- Chaleff F
- Chambilla JMC
- Chandna H
- Chane M
- Chang M
- Chaudhary S
- Chavez V-CER
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- Chen J
- Chen Y
- Cheng S-C
- Cheng X
- Chiang C-E
- Chiang C-E
- Chizhov P
- Chopda M
- Chopra VK
- Christenson S
- Chu A
- Chua T
- Chumakova G
- Chumburidze V
- Civeira Murillo F
- Claeys M
- Clemmensen P
- Clerc J
- Cleveland D
- Clifford P
- Clifton S
- Coching RM
- Codutti OR
- Cohen S
- Collins N
- Colombo HR
- Colquhoun D
- Commerford PJ
- Concha YMR
- Conrad G
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- Constantinescu MCA
- Convens C
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- Correa Flores RM
- Cosavalente LAC
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- Dalby AJ
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- Davidovic G
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- De Berrazueta Fernandez JR
- De Cesare NB
- De Leo A
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- De Mora Martin M
- De Pellegrin A
- De Salazar DIM
- de Santos MON
- de Silva HA
- de Souza JA
- De Wolf L
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- Demirtas M
- Denham D
- Devarapalli SK
- DeVore AD
- Diamantis S
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- Dickey S
- Dilic M
- Dimkovic S
- Dimov BI
- Dincic DV
- Ding C
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- Dorobantu M
- Dorsel T
- Dran RD
- Drexel H
- Drzewiecka A
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- Ducrocq G
- Duda N
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- Dukat A
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- Dupuis R
- Durak-Nalbantic A
- Duronto EA
- Dzupina A
- Dzyak G
- Eagerton D
- Eapen Z
- East C
- Eaton C
- Ebrahim IO
- Edelberg JM
- Edes I
- Egorova L
- Eisenberg S
- Ekanayaka R
- El Shahawy M
- El-Ahdab F
- Elias M
- Eliaschewitz FG
- Elliott J
- Endsley P
- Eppinger A
- Erglis A
- Erglis A
- Ersanli M
- Fadlallah H
- Faes D
- Faggiano P
- Fairlamb J
- Fajardo Campos P
- Falukozy J
- Fang C-Y
- Fang W
- Fanghanel Salmon G
- Farhat N
- Farrar M
- Fausto Ovando SR
- Fazekas F
- Fazlibegovic E
- Feitosa GS
- Fell D
- Feng Y
- Fernandes Manenti ERF
- Fernandez Portales J
- Fernandez AM
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- Ferratini M
- Ferrolino A
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- Fishberg R
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- Flores REO
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- Forgosh L
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- Foster R
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- Franek E
- Fras Z
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- Fu G
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- Fuentes Jimenez F
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- Fujimoto K
- Fujinaga H
- Fulop P
- Fulwani MC
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- Gavish D
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- Gerber J
- Gerber R
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- Giesler G
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- Gilbert JM
- Gillespie E
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- Gimple L
- Giordano JA
- Giorgeto FE
- Gislason G
- Giuliano ME
- Gniot J
- Goch A
- Goloborodko B
- Gomez Vilamajo OA
- Gonsorcik J
- Gonzales RJV
- Gonzalez Diaz B
- Gonzalez Salas LG
- Gonzalez-Juanatey C
- Gonzalez-Juanatey JR
- Goodman SG
- Goodman SG
- Gordeev I
- Gordienko A
- Gorny J
- Gosselin G
- Gosselink ATM
- Gotcheva NN
- Gotcheva NN
- Govinda RA
- Goyal NK
- Gremmler U
- Grewal JS
- Griffiths H
- Gring C
- Groenemeijer BE
- Groutars RGEJ
- Guardigli G
- Guerrero De Leon M
- Guha S
- Gullestad L
- Guneri S
- Guneri S
- Guo Y
- Gurevich V
- Gusi Tragant G
- Guzman PN
- Haddad T
- Hagstrom E
- Hagstrom E
- Hahalis PIG
- Halabi M
- Halcox J
- Hald F
- Haldis T
- Hall J
- Halvorsen S
- Hameed A
- Haniffa R
- Hanotin C
- Hansen O
- Haraguchi T
- Harding S
- Harkut P
- Harrington RA
- Harris B
- Harris B
- Hart H
- Hata Y
- Hattler B
- Hedman A
- Heidenreich L
- Heinc P
- Heitzer T
- Hemetsberger R
- Henderson D
- Henkin Y
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- Herazo AS
- Hermans K
- Hermans WRM
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- Herrman JPR
- Hersbach FMRJ
- Hess CN
- Higashikata T
- Higuera JD
- Hii CLS
- Hirayama A
- Hirooka K
- Hlatky MA
- Hoag G
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- Hoppe U
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- Horvath I
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- Hove JD
- Hrabar AD
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- Hsieh I-C
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- Huang W
- Huber K
- Huidobro L
- Huikuri H
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- Hussein O
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- Hwang J-J
- II TC
- III DG
- III KG
- Ilic S
- Ilieva-Pandeva KA
- Ince C
- Iniguez A
- Investigators ODYSSEYOUTCOMES
- Iqbal SMR
- Irimpen A
- Istratoaie O
- Ito K
- Ivanov IG
- Ivanova R
- Ivanovic N
- Iyengar SS
- Izzo M
- Jacoby D
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- Janik M
- Janosik D
- Jaramillo N
- Jatin FGM
- Jaworska K
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- Jensen SA
- Jensen SA
- Jeong MH
- Jeppesen J
- Jeserich M
- Jiang W
- Jintapakorn W
- Johansen PB
- Jonas M
- Jones WS
- Jordan JD
- Jortveit J
- Joshi AB
- Joshi P
- Jovin I
- Jr CE
- Jr HW
- Jr LC
- Jr MJ
- Jr PW
- Jr RW
- Jr SJ
- Jr SJF
- Jr WD
- Jujjuru S
- Jukema JW
- Juonala M
- Jure HO
- Jurgaitiene R
- Kadr H
- Kaewsuwanna P
- Kahali D
- Kaikkonen K
- Kaiser S
- Kalashetti S
- Kalil R
- Kamensky G
- Kamiya H
- Kandasamy B
- Kapin T
- Kaplan R
- Kapp IE
- Karalis I
- Karlsberg R
- Karna S
- Karpenko O
- Karpenko Y
- Karpov Y
- Karpov Y
- Kartalis A
- Kasim S
- Katona A
- Katsuda Y
- Katz A
- Kaucak V
- Kavaliauskiene R
- Kawasaki T
- Ke Y
- Keating F
- Kedev S
- Keen W
- Kehasukcharoen W
- Kelsey SF
- Kerkar P
- Khabeishvili G
- Khaira AS
- Khaisheva L
- Khan A
- Khan A
- Khan M
- Khasanov N
- Khintibidze I
- Khurana S
- Kibarskis A
- Kichukov KN
- Killat H
- Kim C
- Kim HS
- Kim MH
- Kim S-H
- Kimmelstiel C
- Kimura K
- Kimura T
- King M
- Kirma C
- Kishi K
- Kiss RG
- Kiss RG
- Kiviniemi T
- Kjovkaroski A
- Klancke K
- Klantsa A
- Klausen IC
- Kline G
- Klutstein M
- Knickelbine T
- Knowles JW
- Knutson T
- Koba S
- Kobalava Z
- Kobayashi J
- Koike A
- Koldas L
- Kolls BJ
- Kondo NI
- Kong DF
- Kopytsya M
- Koren M
- Kormann A
- Kornder J
- Kornowski R
- Korol M
- Kosinski E
- Kosmachova E
- Kostarska-Srokosz E
- Kostis J
- Kotha P
- Kouz S
- Kovalskyi I
- Kozuma K
- Krasowski W
- Krawczyk J
- Krichmar P
- Kristensen KS
- Kubica J
- Kubilius R
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- Kuhlman P
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- Kumar P
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- Publication venue
- 'Oxford University Press (OUP)'
- Publication date
- 01/01/2019
- Field of study
Aims The third Universal Definition of Myocardial Infarction (MI) Task Force classified MIs into five types: Type 1, spontaneous; Type 2, related to oxygen supply/demand imbalance; Type 3, fatal without ascertainment of cardiac biomarkers; Type 4, related to percutaneous coronary intervention; and Type 5, related to coronary artery bypass surgery. Low-density lipoprotein cholesterol (LDL-C) reduction with statins and proprotein convertase subtilisin–kexin Type 9 (PCSK9) inhibitors reduces risk of MI, but less is known about effects on types of MI. ODYSSEY OUTCOMES compared the PCSK9 inhibitor alirocumab with placebo in 18 924 patients with recent acute coronary syndrome (ACS) and elevated LDL-C (≥1.8 mmol/L) despite intensive statin therapy. In a pre-specified analysis, we assessed the effects of alirocumab on types of MI. Methods and results Median follow-up was 2.8 years. Myocardial infarction types were prospectively adjudicated and classified. Of 1860 total MIs, 1223 (65.8%) were adjudicated as Type 1, 386 (20.8%) as Type 2, and 244 (13.1%) as Type 4. Few events were Type 3 (n = 2) or Type 5 (n = 5). Alirocumab reduced first MIs [hazard ratio (HR) 0.85, 95% confidence interval (CI) 0.77–0.95; P = 0.003], with reductions in both Type 1 (HR 0.87, 95% CI 0.77–0.99; P = 0.032) and Type 2 (0.77, 0.61–0.97; P = 0.025), but not Type 4 MI. Conclusion After ACS, alirocumab added to intensive statin therapy favourably impacted on Type 1 and 2 MIs. The data indicate for the first time that a lipid-lowering therapy can attenuate the risk of Type 2 MI. Low-density lipoprotein cholesterol reduction below levels achievable with statins is an effective preventive strategy for both MI types.For complete list of authors see http://dx.doi.org/10.1093/eurheartj/ehz299</p
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- Zhong Q
- Zhou A
- Zhou B
- Zhou C
- Zhou G
- Zhou H
- Zhou H
- Zhou H
- Zhou J
- Zhou J
- Zhou J
- Zhou J
- Zhou K
- Zhou R
- Zhou X-J
- Zhou Y
- Zhou Y
- Zhou Y
- Zhou Z
- Zhou Z-Y
- Zhu B
- Zhu C
- Zhu G-Q
- Zhu H
- Zhu H
- Zhu H
- Zhu W-G
- Zhu Y
- Zhu Y
- Zhuang H
- Zhuang X
- Zientara-Rytter K
- Zimmermann CM
- Ziviani E
- Zoladek T
- Zong W-X
- Zorov DB
- Zorzano A
- Zou W
- Zou Z
- Zou Z
- Zuryn S
- Zwerschke W
- Álvarez ÉMC
- Ávalos Y
- Önal G
- Üstün S
- Čolić M
- Đokić J
- Žerovnik E
- Publication venue
- 'Informa UK Limited'
- Publication date
- 01/01/2021
- Field of study
In 2008, we published the first set of guidelines for standardizing research in autophagy. Since then, this topic has received increasing attention, and many scientists have entered the field. Our knowledge base and relevant new technologies have also been expanding. Thus, it is important to formulate on a regular basis updated guidelines for monitoring autophagy in different organisms. Despite numerous reviews, there continues to be confusion regarding acceptable methods to evaluate autophagy, especially in multicellular eukaryotes. Here, we present a set of guidelines for investigators to select and interpret methods to examine autophagy and related processes, and for reviewers to provide realistic and reasonable critiques of reports that are focused on these processes. These guidelines are not meant to be a dogmatic set of rules, because the appropriateness of any assay largely depends on the question being asked and the system being used. Moreover, no individual assay is perfect for every situation, calling for the use of multiple techniques to properly monitor autophagy in each experimental setting. Finally, several core components of the autophagy machinery have been implicated in distinct autophagic processes (canonical and noncanonical autophagy), implying that genetic approaches to block autophagy should rely on targeting two or more autophagy-related genes that ideally participate in distinct steps of the pathway. Along similar lines, because multiple proteins involved in autophagy also regulate other cellular pathways including apoptosis, not all of them can be used as a specific marker for bona fide autophagic responses. Here, we critically discuss current methods of assessing autophagy and the information they can, or cannot, provide. Our ultimate goal is to encourage intellectual and technical innovation in the field
Global burden of 369 diseases and injuries in 204 countries and territories, 1990-2019: a systematic analysis for the Global Burden of Disease Study 2019
- Author
- Abbafati C
- Abbas KM
- Abbasi M
- Abbasi-Kangevari M
- Abbasifard M
- Abbastabar H
- Abd El Razek HM
- Abd El Razek MM
- Abd-Allah F
- Abdelalim A
- Abdollahi M
- Abdollahpour I
- Abdulkader RS
- Abdullah KH
- Abedi A
- Abedi P
- Abegaz KH
- Abolhassani H
- Abosetugn AE
- Aboyans V
- Abrams EM
- Abreu LG
- Abrigo MRM
- Abu Haimed AK
- Abu-Gharbieh E
- Abu-Raddad LJ
- Abualhasan A
- Abushouk AI
- Acebedo A
- Ackerman IN
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- Adamu AA
- Adebayo OM
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- Adelson JD
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- Oh I-H
- Oiu AO
- Okunga EW
- Oladnabi M
- Olagunju AT
- Olusanya BO
- Olusanya JO
- Oluwasanu MM
- Omer MO
- Ong KL
- Ong S
- Onwujekwe OE
- Oren E
- Orji AU
- Orpana HM
- Ortega-Altamirano DV
- Ortiz A
- Osarenotor O
- Osei FB
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- Ostroff SM
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- Owolabi MO
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- Ranabhat CL
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- Sudaryanto A
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- Tesema GA
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- Troeger CE
- Truelsen TC
- Tsai AC
- Tsatsakis A
- Tyrovolas S
- Uddin R
- Ullah I
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- Umeokonkwo CD
- Undurraga EA
- Unnikrishnan B
- Upadhyay E
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- Vakilian A
- Valdez PR
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- Venketasubramanian N
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- Wickramasinghe ND
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- Woldu G
- Wolfe CDA
- Wondmeneh TG
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- Wu A-M
- Wu C
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- Wunrow HY
- Xie Y
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- Yamagishi K
- Yaminfirooz M
- Yano Y
- Yaya S
- Yazdi-Feyzabadi V
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- Yeheyis TY
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- Yilgwan CS
- Yilma MT
- Yip P
- Yonemoto N
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- York HW
- Younis MZ
- Younker TP
- Yousefi B
- Yousefi Z
- Yousefifard M
- Yousefinezhadi T
- Yousuf AY
- Yu C
- Yu Y
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- Yuce D
- Yusefzadeh H
- Zadey S
- Zahabi SS
- Zaidi SS
- Zaki L
- Zaki MES
- Zakzuk J
- Zamani M
- Zamanian M
- Zandian H
- Zangeneh A
- Zarafshan H
- Zastrozhin MS
- Zewdie KA
- Zhang J
- Zhang Y
- Zhang Z-J
- Zhao JT
- Zhao X-JG
- Zhao Y
- Zheleva B
- Zheng P
- Zhou M
- Zhu C
- Ziapour A
- Zimsen SRM
- Zlavog BS
- Zodpey S
- Publication venue
- 'Elsevier BV'
- Publication date
- 17/10/2020
- Field of study
Five insights from the Global Burden of Disease Study 2019
- Author
- Abbafati C
- Abbas KM
- Abbasi M
- Abbasi-Kangevari M
- Abbasifard M
- Abbastabar H
- Abd El Razek HM
- Abd El Razek MM
- Abd-Allah F
- Abdelalim A
- Abdollahi M
- Abdollahpour I
- Abdulkader RS
- Abdullah KH
- Abedi A
- Abedi P
- Abegaz KH
- Abolhassani H
- Abosetugn AE
- Aboyans V
- Abrams EM
- Abreu LG
- Abrigo MRM
- Abu Haimed AK
- Abu-Gharbieh E
- Abu-Raddad LJ
- Abualhasan A
- Abushouk AI
- Acebedo A
- Ackerman IN
- Adabi M
- Adair T
- Adamu AA
- Adebayo OM
- Adedeji IA
- Adekanmbi V
- Adelson JD
- Adeoye AM
- Adetokunboh OO
- Adham D
- Advani SM
- Afarideh M
- Afshari M
- Afshin A
- Agardh EE
- Agarwal G
- Agasthi P
- Agesa KM
- Aghaali M
- Aghamir SMK
- Agrawal A
- Ahmad T
- Ahmadi A
- Ahmadi K
- Ahmadi M
- Ahmadieh H
- Ahmadpour E
- Ahmed MB
- Aji B
- Akalu TY
- Akinyemi RO
- Akinyemiju T
- Akombi B
- Akunna CJ
- Al-Aly Z
- Al-Mekhlafi HM
- Al-Raddadi RM
- Alahdab F
- Alam K
- Alam N
- Alam S
- Alam T
- Alanezi FM
- Alanzi TM
- Albertson SB
- Alcalde-Rabanal JE
- Alema NM
- Alemu BW
- Alemu YM
- Alhabib KF
- Alhassan RK
- Ali M
- Ali S
- Alicandro G
- Alijanzadeh M
- Alinia C
- Alipour V
- Alizade H
- Aljunid SM
- Alla F
- Allebeck P
- Almadi MAH
- Almasi A
- Almasi-Hashiani A
- Almasri NA
- Almulhim AM
- Alonso J
- Altirkawi KA
- Alumran AK
- Alvis-Guzman N
- Alvis-Zakzuk NJ
- Amare AT
- Amare B
- Amini S
- Amini-Rarani M
- Aminorroaya A
- Amiri F
- Amit AML
- Amugsi DA
- Amul GGH
- Anbesu EW
- Ancuceanu R
- Anderlini D
- Anderson JA
- Andrei CL
- Andrei T
- Androudi S
- Angus C
- Anjomshoa M
- Ansari F
- Ansari I
- Ansari-Moghaddam A
- Antonazzo IC
- Antonio CAT
- Antony CM
- Antriyandarti E
- Anvari D
- Anwer R
- Appiah SCY
- Arab-Zozani M
- Arabloo J
- Aravkin AY
- Arba AAK
- Aremu O
- Ariani F
- Aripov T
- Armoon B
- Arnlov J
- Arowosegbe OO
- Aryal KK
- Arzani A
- Asaad M
- Asadi-Aliabadi M
- Asadi-Pooya AA
- Asgari S
- Asghari B
- Ashbaugh C
- Assmus M
- Atafar Z
- Athari SS
- Atnafu DD
- Atout MMW
- Atre SR
- Atteraya MS
- Ausloos F
- Ausloos M
- Avila-Burgos L
- Avokpaho EFGA
- Ayano G
- Ayanore MA
- Aynalem GL
- Aynalem YA
- Ayza MA
- Azari S
- Azarian G
- Azene ZN
- Azhar G
- Azzopardi PS
- Babaee E
- Badawi A
- Badiye AD
- Bagherzadeh M
- Bagli E
- Bahrami MA
- Baig AA
- Bairwa M
- Bakhshaei MH
- Bakhtiari A
- Bakkannavar SM
- Balachandran A
- Balakrishnan S
- Balalla S
- Balassyano S
- Baldasseroni A
- Bali AO
- Ball K
- Ballew SH
- Balzi D
- Banach M
- Bandpei MAM
- Banerjee SK
- Banik PC
- Bannick MS
- Bante AB
- Bante SA
- Baraki AG
- Barboza MA
- Barker-Collo SL
- Barnighausen TW
- Barrero LH
- Barthelemy CM
- Barua L
- Barzegar A
- Basaleem H
- Bassat Q
- Basu S
- Baune BT
- Bayati M
- Baye BA
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- Becker JS
- Bedi N
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- Benziger CP
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- Bernabe E
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- Bhutta ZA
- Bibi S
- Bicer BK
- Biehl MH
- Bijani A
- Bikbov B
- Bilano V
- Bin Sayeed MS
- Bin Zaman S
- Biondi A
- Birihane BM
- Bisanzio D
- Bisignano C
- Biswas RK
- Bitew H
- Bjorge T
- Bockarie MJ
- Bohlouli S
- Bohluli M
- Bojia HA
- Bolla SR
- Boloor A
- Boon-Dooley AS
- Borges G
- Borzi AM
- Borzouei S
- Bose D
- Bosetti C
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- Boufous S
- Bourne R
- Brady OJ
- Braithwaite D
- Brauer M
- Brayne C
- Breitborde NJK
- Breitner S
- Brenner H
- Breusov AV
- Briant PS
- Briggs AM
- Briko AN
- Briko NI
- Britton GB
- Brugha T
- Bryazka D
- Buchbinder R
- Bumgarner BR
- Burkart K
- Burnett RT
- Busse R
- Butt ZA
- Caetano dos Santos FL
- Cahill LE
- Cahuana-Hurtado L
- Cai T
- Callender CSKH
- Camera LA
- Campos-Nonato IR
- Cao J
- Car J
- Car LT
- Cardenas R
- Carreras G
- Carrero JJ
- Carvalho F
- Castaldelli-Maia JM
- Castaneda-Orjuela CA
- Castelpietra G
- Castle CD
- Castro E
- Castro F
- Catala-Lopez F
- Causey K
- Cederroth CR
- Cercy KM
- Cerin E
- Chalek J
- Chandan JS
- Chang AR
- Chang AY
- Chang J-C
- Chang K-L
- Charan J
- Charlson FJ
- Chattu VK
- Chaturvedi S
- Cherbuin N
- Chimed-Ochir O
- Chin KL
- Chirinos-Caceres JL
- Cho DY
- Choi J-YJ
- Christensen H
- Chu D-T
- Chung MT
- Chung S-C
- Cicuttini FM
- Ciobanu LG
- Cirillo M
- Cislaghi B
- Classen TKD
- Cohen AJ
- Collins EL
- Comfort H
- Compton K
- Conti S
- Cooper OR
- Corso B
- Cortesi PA
- Costa VM
- Cousin E
- Cowden RG
- Cowie BC
- Cromwell EA
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- Cross DH
- Cross M
- Crowe CS
- Cruz JA
- Cummins S
- Cunningham M
- D'Amico E
- da Silva DD
- Dahlawi SMA
- Dai H
- Dai H
- Damasceno AAM
- Damiani G
- Dandona L
- Dandona R
- Daneshpajouhnejad P
- Dangel WJ
- Danielsson A-K
- Dargan PI
- Darshan BB
- Darwesh AM
- Daryani A
- Das Gupta R
- Das Neves J
- Das JK
- Dash AP
- Davey G
- Davila-Cervantes CA
- Davis AC
- Davitoiu DV
- Davletov K
- De Leo D
- De Neve J-W
- Dean FE
- DeCleene NK
- Deen A
- Defo BK
- Degenhardt L
- DeLang M
- Dellavalle RP
- Demeke FM
- Demoz GT
- Demsie DG
- Denova-Gutierrez E
- Dereje ND
- Deribe K
- Dervenis N
- Desai R
- Desalew A
- Dessie GA
- Deuba K
- Dharmaratne SD
- Dhungana GP
- Dianatinasab M
- Diaz D
- Dichgans M
- Didarloo A
- Dingels ZV
- Dippenaar IN
- Dirac MA
- Djalalinia S
- Do HT
- Dokova K
- Doku DT
- Dolecek C
- Dolgert AJ
- Dorostkar F
- Doshi CP
- Doshi PP
- Doshmangir L
- Douiri A
- Doxey MC
- Doyle KE
- Driscoll TR
- Dubljanin E
- Dunachie SJ
- Duncan BB
- Duraes AR
- Eagan AW
- Ebrahimi H
- Edvardsson D
- Effiong A
- Ehrlich JR
- El Nahas N
- El Sayed I
- El Tantawi M
- El-Jaafary SI
- Elbarazi I
- Elgendy IY
- Elhabashy HR
- Elsharkawy A
- Elyazar IRF
- Emamian MH
- Emmons-Bell S
- Erskine HE
- Eshrati B
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- Eskandarieh S
- Esmaeilnejad S
- Esmaeilzadeh F
- Esteghamati A
- Esteghamati S
- Estep K
- Etemadi A
- Etisso AE
- Ezekannagha O
- Fanzo J
- Farag T
- Farahmand M
- Faraj A
- Faraon EJA
- Fareed M
- Faridnia R
- Farinha CSES
- Farioli A
- Faris PS
- Faro A
- Faruque M
- Farzadfar F
- Fattahi N
- Fazaeli AA
- Fazlzadeh M
- Feigin VL
- Feldman R
- Fereshtehnejad S-M
- Fernandes E
- Ferrara G
- Ferrara P
- Ferrari AJ
- Ferreira ML
- Feyissa GT
- Filip I
- Fischer F
- Fisher JL
- Fitzgerald R
- Flohr C
- Flor LS
- Foigt NA
- Folayan MO
- Fomenkov AA
- Force LM
- Fornari C
- Forooshani ZSD
- Foroutan M
- Fox JT
- Francis JM
- Frank TD
- Franklin RC
- Freitas M
- Fu W
- Fukumoto T
- Fukutaki K
- Fuller JE
- Fullman N
- Furtado JM
- Gad MM
- Gaidhane AM
- Gakidou E
- Galles NC
- Gallus S
- Gamkrelidze A
- Garcia-Basteiro AL
- Gardner WM
- Geberemariyam BS
- Gebrehiwot AM
- Gebremedhin KB
- Gebremeskel GG
- Gebremeskel LG
- Gebresillassie BM
- Gebreslassie AAAA
- Gela JD
- Geramo YCD
- Geremew A
- Gesesew HA
- Gething PW
- Gezae KE
- Ghadimi M
- Ghadiri K
- Ghaffarifar F
- Ghafourifard M
- Ghajar A
- Ghamari F
- Ghashghaee A
- Ghiasvand H
- Ghith N
- Gholamian A
- Ghosh R
- Giampaoli S
- Gilani SA
- Gill PS
- Gill TK
- Gillum RF
- Ginawi IA
- Ginindza TG
- Gitimoghaddam M
- Giussani G
- Glagn M
- Glushkova EV
- Gnedovskaya EV
- Godinho MA
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- Golechha M
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- Gopalani SV
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- Gorini G
- Gorman TM
- Gottlich HC
- Goudarzi H
- Goudarzian AH
- Goulart AC
- Goulart BNG
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- Grosso G
- Gubari MIM
- Gudi N
- Gugnani HC
- Guimaraes ALS
- Guimaraes RA
- Guled RA
- Gultie T
- Guo G
- Guo Y
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- Gupta T
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- Hachinski V
- Haddock B
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- Hafiz A
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- Haile LM
- Haile TG
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- Haj-Mirzaian A
- Hall BJ
- Halvaei I
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- Hameed S
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- Hamilton EB
- Hammer MS
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- Hanif A
- Hankey GJ
- Hanson SW
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- Harvey JD
- Hasaballah AI
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- Hashemian M
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- Hassanipour S
- Hassankhani H
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- Publication venue
- Publication date
- 01/01/2020
- Field of study
The Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2019 provides a rules-based synthesis of the available evidence on levels and trends in health outcomes, a diverse set of risk factors, and health system responses. GBD 2019 covered 204 countries and territories, as well as first administrative level disaggregations for 22 countries, from 1990 to 2019. Because GBD is highly standardised and comprehensive, spanning both fatal and non-fatal outcomes, and uses a mutually exclusive and collectively exhaustive list of hierarchical disease and injury causes, the study provides a powerful basis for detailed and broad insights on global health trends and emerging challenges. GBD 2019 incorporates data from 281 586 sources and provides more than 3.5 billion estimates of health outcome and health system measures of interest for global, national, and subnational policy dialogue. All GBD estimates are publicly available and adhere to the Guidelines on Accurate and Transparent Health Estimate Reporting. From this vast amount of information, five key insights that are important for health, social, and economic development strategies have been distilled. These insights are subject to the many limitations outlined in each of the component GBD capstone papers.Peer reviewe
Global age-sex-specific fertility, mortality, healthy life expectancy (HALE), and population estimates in 204 countries and territories, 1950-2019 : a comprehensive demographic analysis for the Global Burden of Disease Study 2019
- Author
- Abbafati Cristiana
- Abbas Kaja M.
- Abbasi Mohammad
- Abbasi-Kangevari Mohsen
- Abbasifard Mitra
- Abbastabar Hedayat
- Abd-Allah Foad
- Abdelalim Ahmed
- Abdollahi Mohammad
- Abdollahpour Ibrahim
- Abedi Aidin
- Abedi Parisa
- Abegaz Kedir H.
- Abolhassani Hassan
- Abosetugn Akine E.
- Aboyans Victor
- Abrams Elissa M.
- Abreu Lucas G.
- Abrigo Michael R. M.
- Abu Haimed Abdulaziz K.
- Abu-Gharbieh Eman
- Abu-Raddad Laith J.
- Abualhasan Ahmed
- Abushouk Abdelrahman I.
- Acebedo Alyssa
- Ackerman Ilana N.
- Adabi Maryam
- Adair Tim
- Adamu Abdu A.
- Adebayo Oladimeji M.
- Adedeji Isaac A.
- Adekanmbi Victor
- Adelson Jaimie D.
- Adeoye Abiodun M.
- Adetokunboh Olatunji O.
- Adham Davoud
- Advani Shailesh M.
- Afarideh Mohsen
- Afshari Mahdi
- Afshin Ashkan
- Agardh Emilie E.
- Agarwal Gina
- Agasthi Pradyumna
- Agesa Kareha M.
- Aghaali Mohammad
- Aghamir Seyed M.
- Agrawal Anurag
- Ahmad Tauseef
- Ahmadi Alireza
- Ahmadi Keivan
- Ahmadi Mehdi
- Ahmadieh Hamid
- Ahmadpour Ehsan
- Ahmed Muktar B.
- Aji Budi
- Akalu Temesgen Y.
- Akinyemi Rufus O.
- Akinyemiju Tomi
- Akombi Blessing J.
- Akunna Chisom J.
- Al-Aly Ziyad
- Al-Mekhlaf Hesham M.
- Al-Raddadi Rajaa
- Alahdab Fares
- Alam Khurshid
- Alam Noore
- Alam Samiah
- Alam Tahiya
- Alanezi Fahad M.
- Alanzi Turki M.
- Albertson Samuel B.
- Alcalde-Rabanal Jacqueline E.
- Alema Niguse M.
- Alemu Biresaw W.
- Alemu Yihun M.
- Alhabib Khalid F.
- Alhassan Robert K.
- Ali Muhammad
- Ali Saqib
- Alicandro Gianfranco
- Alijanzadeh Mehran
- Alinia Cyrus
- Alipour Vahid
- Alizade Hesam
- Aljunid Syed M.
- Alla François
- Allebeck Peter
- Almadi Majid A.
- Almasi Ali
- Almasi-Hashiani Amir
- Almasri Nihad A.
- Almulhim Abdulaziz M.
- Alonso Jordi
- Altirkawi Khalid A.
- Alumran Arwa K.
- Alvis-Guzman Nelson
- Alvis-Zakzuk Nelson J.
- Amare Azmeraw T.
- Amare Bekalu
- Amini Saeed
- Amini-Rarani Mostafa
- Aminorroaya Arya
- Amiri Fatemeh
- Amit Arianna M.
- Amugsi Dickson A.
- Amul Gianna G.
- Anbesu Etsay W.
- Ancuceanu Robert
- Anderlini Deanna
- Anderson Jason A.
- Andrei Catalina L.
- Andrei Tudorel
- Androudi Sofia
- Angus Colin
- Anjomshoa Mina
- Ansari Fereshteh
- Ansari Iman
- Ansari-Moghaddam Alireza
- Antonazzo Ippazio C.
- Antonio Carl A.
- Antony Catherine M.
- Antriyandarti Ernoiz
- Anvari Davood
- Anwer Razique
- Appiah Seth C.
- Arab-Zozani Morteza
- Arabloo Jalal
- Aravkin Aleksandr Y.
- Arba Aseb A.
- Aremu Olatunde
- Ariani Filippo
- Aripov Timur
- Armoon Bahram
- Arowosegbe Oluwaseyi O.
- Aryal Krishna K.
- Arzani Afsaneh
- Asaad Malke
- Asadi-Aliabadi Mehran
- Asadi-Pooya Ali A.
- Asgari Samaneh
- Asghari Jafarabadi Mohammad
- Asghari Babak
- Ashbaugh Charlie
- Assmus Michael
- Atafar Zahra
- Athari Seyyed S.
- Atnafu Desta D.
- Atout Maha M.
- Atre Sachin R.
- Atteraya Madhu
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- Olusanya Jacob O.
- Oluwasanu Mojisola M.
- Omer Omer Muktar
- Ong Kanyin
- Ong Sokking
- Onwujekwe Obinna E.
- Oren Eyal
- Orji Aislyn U.
- Orpana Heather M.
- Ortega-Altamirano Doris V.
- Ortiz Alberto
- Osarenotor Osayomwanbo
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- Ostojic Sergej M.
- Ostroff Samuel M.
- Otoiu Adrian
- Otstavnov Nikita
- Otstavnov Stanislav S.
- Owolabi Mayowa O.
- P. A. Mahesh
- Padubidri Jagadish R.
- Pakhale Smita
- Pakhare Abhijit P.
- Pakshir Keyvan
- Palladino Raffaele
- Pana Adrian
- Panda-Jonas Songhomitra
- Pandey Anamika
- Pangaribuan Helena U.
- Park Eun-Kee
- Park James
- Parmar Priya
- Parry Charles D.
- Pasovic Maja
- Pasupula Deepak K.
- Patel Jenil R.
- Patel Sangram K.
- Paternina-Caicedo Angel J.
- Pathak Ashish
- Pathak Mona
- Patten Scott B.
- Patton George C.
- Paudel Deepak
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- Pereira David M.
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- Pescarini Julia M.
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- Pham Hai Q.
- Phillips Michael R.
- Piccinelli Cristiano
- Pierce Maxwell
- Pigott David M.
- Pilgrim Thomas
- Pilz Tessa M.
- Piradov Michael A.
- Pirsaheb Meghdad
- Pishgar Farhad
- Plana-Ripoll Oleguer
- Plass Dietrich
- Pletche Martin
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- Polibin Roman V.
- Polinder Suzanne
- Polkinghorne Kevan R.
- Pond Constance D.
- Postma Maarten J.
- Pottoo Faheem H.
- Pourjafar Hadi
- Pourmalek Farshad
- Pourmirza Kalhori Reza
- Pourshams Akram
- Poznanska Anna
- Prada Sergio I.
- Prakash Sanjay
- Prakash V.
- Prasad Narayan
- Preotescu Liliana
- Pribadi Dimas R.
- Pupillo Elisabetta
- Quazi Syed Zahiruddin
- Rabiee Mohammad
- Rabiee Navid
- Radfar Amir
- Rafiee Ata
- Rafiei Alireza
- Raggi Alberto
- Rahim Fakher
- Rahimi-Movaghar Afarin
- Rahman Mohammad H.
- Rahman Muhammad A.
- Rajabpour-Sanati Ali
- Rajati Fatemeh
- Rakovac Ivo
- Ram Pradhum
- Ramezanzadeh Kiana
- Rana Saleem M.
- Ranabhat Chhabi L.
- Ranta Annemarei
- Rao Puja C.
- Rao Sowmya J.
- Rasella Davide
- Rashedi Vahid
- Rastogi Prateek
- Rath Goura K.
- Rathi Priya
- Rawaf David L.
- Rawaf Salman
- Rawal Lal
- Rawassizadeh Reza
- Rawat Ramu
- Razo Christian
- Redford Sofia B.
- Regassa Lemma D.
- Reiner Robert C.
- Reinig Nickolas
- Reitsma Marissa B.
- Remuzzi Giuseppe
- Renjith Vishnu
- Renzaho Andre M. N. (R17978)
- Ärnlöv Johan
- Øverland Simon
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2020
- Field of study
Background: Accurate and up-to-date assessment of demographic metrics is crucial for understanding a wide range of social, economic, and public health issues that affect populations worldwide. The Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2019 produced updated and comprehensive demographic assessments of the key indicators of fertility, mortality, migration, and population for 204 countries and territories and selected subnational locations from 1950 to 2019.
Methods: 8078 country-years of vital registration and sample registration data, 938 surveys, 349 censuses, and 238 other sources were identified and used to estimate age-specific fertility. Spatiotemporal Gaussian process regression (ST-GPR) was used to generate age-specific fertility rates for 5-year age groups between ages 15 and 49 years. With extensions to age groups 10–14 and 50–54 years, the total fertility rate (TFR) was then aggregated using the estimated age-specific fertility between ages 10 and 54 years. 7417 sources were used for under-5 mortality estimation and 7355 for adult mortality. ST-GPR was used to synthesise data sources after correction for known biases. Adult mortality was measured as the probability of death between ages 15 and 60 years based on vital registration, sample registration, and sibling histories, and was also estimated using ST-GPR. HIV-free life tables were then estimated using estimates of under-5 and adult mortality rates using a relational model life table system created for GBD, which closely tracks observed age-specific mortality rates from complete vital registration when available. Independent estimates of HIV-specific mortality generated by an epidemiological analysis of HIV prevalence surveys and antenatal clinic serosurveillance and other sources were incorporated into the estimates in countries with large epidemics. Annual and single-year age estimates of net migration and population for each country and territory were generated using a Bayesian hierarchical cohort component model that analysed estimated age-specific fertility and mortality rates along with 1250 censuses and 747 population registry years. We classified location-years into seven categories on the basis of the natural rate of increase in population (calculated by subtracting the crude death rate from the crude birth rate) and the net migration rate. We computed healthy life expectancy (HALE) using years lived with disability (YLDs) per capita, life tables, and standard demographic methods. Uncertainty was propagated throughout the demographic estimation process, including fertility, mortality, and population, with 1000 draw-level estimates produced for each metric. Findings: The global TFR decreased from 2·72 (95% uncertainty interval [UI] 2·66–2·79) in 2000 to 2·31 (2·17–2·46) in 2019. Global annual livebirths increased from 134·5 million (131·5–137·8) in 2000 to a peak of 139·6 million (133·0–146·9) in 2016. Global livebirths then declined to 135·3 million (127·2–144·1) in 2019. Of the 204 countries and territories included in this study, in 2019, 102 had a TFR lower than 2·1, which is considered a good approximation of replacement-level fertility. All countries in sub-Saharan Africa had TFRs above replacement level in 2019 and accounted for 27·1% (95% UI 26·4–27·8) of global livebirths. Global life expectancy at birth increased from 67·2 years (95% UI 66·8–67·6) in 2000 to 73·5 years (72·8–74·3) in 2019. The total number of deaths increased from 50·7 million (49·5–51·9) in 2000 to 56·5 million (53·7–59·2) in 2019. Under-5 deaths declined from 9·6 million (9·1–10·3) in 2000 to 5·0 million (4·3–6·0) in 2019. Global population increased by 25·7%, from 6·2 billion (6·0–6·3) in 2000 to 7·7 billion (7·5–8·0) in 2019. In 2019, 34 countries had negative natural rates of increase; in 17 of these, the population declined because immigration was not sufficient to counteract the negative rate of decline. Globally, HALE increased from 58·6 years (56·1–60·8) in 2000 to 63·5 years (60·8–66·1) in 2019. HALE increased in 202 of 204 countries and territories between 2000 and 2019
Global burden of 369 diseases and injuries in 204 countries and territories, 1990–2019: a systematic analysis for the Global Burden of Disease Study 2019
- Author
- Abbafati Cristiana
- Abbas Kaja M.
- Abbasi Mohammad
- Abbasi-Kangevari Mohsen
- Abbasifard Mitra
- Abbastabar Hedayat
- Abd El Razek Hassan Magdy
- Abd El Razek Muhammed Magdy
- Abd-Allah Foad
- Abdelalim Ahmed
- Abdollahi Mohammad
- Abdollahpour Ibrahim
- Abdulkader Rizwan Suliankatchi
- Abdullah Kanaan Hamagharib
- Abedi Aidin
- Abedi Parisa
- Abegaz Kedir Hussein
- Abolhassani Hassan
- Abosetugn Akine Eshete
- Aboyans Victor
- Abrams Elissa M.
- Abreu Lucas Guimaraes
- Abrigo Michael R. M.
- Abu Haimed Abdulaziz Khalid
- Abu-Gharbieh Eman
- Abu-Raddad Laith Jamal
- Abualhasan Ahmed
- Abushouk Abdelrahman I.
- Acebedo Alyssa
- Ackerman Ilana N.
- Adabi Maryam
- Adair Tim
- Adamu Abdu A.
- Adebayo Oladimeji M.
- Adedeji Isaac Akinkunmi
- Adekanmbi Victor
- Adelson Jaimie D.
- Adeoye Abiodun Moshood
- Adetokunboh Olatunji O.
- Adham Davoud
- Advani Shailesh M.
- Afarideh Mohsen
- Afshari Mahdi
- Afshin Ashkan
- Agardh Emilie E.
- Agarwal Gina
- Agasthi Pradyumna
- Agesa Kareha M.
- Aghaali Mohammad
- Aghamir Seyed Mohammad Kazem
- Agrawal Anurag
- Ahmad Tauseef
- Ahmadi Alireza
- Ahmadi Keivan
- Ahmadi Mehdi
- Ahmadieh Hamid
- Ahmadpour Ehsan
- Ahmed Muktar Beshir
- Aji Budi
- Akalu Temesgen Yihunie
- Akinyemi Rufus Olusola
- Akinyemiju Tomi
- Akombi Blessing
- Akunna Chisom Joyqueenet
- Al-Aly Ziyad
- Al-Mekhlafi Hesham M.
- Al-Raddadi Rajaa M.
- Alahdab Fares
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- Alcalde-Rabanal Jacqueline Elizabeth
- Alema Niguse Meles
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- Alemu Yihun Mulugeta
- Alhabib Khalid F.
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- Ali Muhammad
- Ali Saqib
- Alicandro Gianfranco
- Alijanzadeh Mehran
- Alinia Cyrus
- Alipour Vahid
- Alizade Hesam
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- Yusefzadeh Hasan
- Zadey Siddhesh
- Zahabi Saleh Salehi
- Zaidi Syed Saoud
- Zaki Leila
- Zaki Maysaa El Sayed
- Zakzuk Josefina
- Zamani Mohammad
- Zamanian Maryam
- Zandian Hamed
- Zangeneh Alireza
- Zarafshan Hadi
- Zastrozhin Mikhail Sergeevich
- Zewdie Kaleab Alemayehu
- Zhang Jianrong
- Zhang Yunquan
- Zhang Zhi-Jiang
- Zhao Jeff T.
- Zhao Xiu-Ju George
- Zhao Yingxi
- Zheleva Bistra
- Zheng Peng
- Zhou Maigeng
- Zhu Cong
- Ziapour Arash
- Zimsen Stephanie R. M.
- Zlavog Bianca S.
- Zodpey Sanjay
- Publication venue
- Publication date
- 01/01/2020
- Field of study
Background: In an era of shifting global agendas and expanded emphasis on non-communicable diseases and injuries along with communicable diseases, sound evidence on trends by cause at the national level is essential. The Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) provides a systematic scientific assessment of published, publicly available, and contributed data on incidence, prevalence, and mortality for a mutually exclusive and collectively exhaustive list of diseases and injuries. Methods: GBD estimates incidence, prevalence, mortality, years of life lost (YLLs), years lived with disability (YLDs), and disability-adjusted life-years (DALYs) due to 369 diseases and injuries, for two sexes, and for 204 countries and territories. Input data were extracted from censuses, household surveys, civil registration and vital statistics, disease registries, health service use, air pollution monitors, satellite imaging, disease notifications, and other sources. Cause-specific death rates and cause fractions were calculated using the Cause of Death Ensemble model and spatiotemporal Gaussian process regression. Cause-specific deaths were adjusted to match the total all-cause deaths calculated as part of the GBD population, fertility, and mortality estimates. Deaths were multiplied by standard life expectancy at each age to calculate YLLs. A Bayesian meta-regression modelling tool, DisMod-MR 2.1, was used to ensure consistency between incidence, prevalence, remission, excess mortality, and cause-specific mortality for most causes. Prevalence estimates were multiplied by disability weights for mutually exclusive sequelae of diseases and injuries to calculate YLDs. We considered results in the context of the Socio-demographic Index (SDI), a composite indicator of income per capita, years of schooling, and fertility rate in females younger than 25 years. Uncertainty intervals (UIs) were generated for every metric using the 25th and 975th ordered 1000 draw values of the posterior distribution. Findings: Global health has steadily improved over the past 30 years as measured by age-standardised DALY rates. After taking into account population growth and ageing, the absolute number of DALYs has remained stable. Since 2010, the pace of decline in global age-standardised DALY rates has accelerated in age groups younger than 50 years compared with the 1990–2010 time period, with the greatest annualised rate of decline occurring in the 0–9-year age group. Six infectious diseases were among the top ten causes of DALYs in children younger than 10 years in 2019: lower respiratory infections (ranked second), diarrhoeal diseases (third), malaria (fifth), meningitis (sixth), whooping cough (ninth), and sexually transmitted infections (which, in this age group, is fully accounted for by congenital syphilis; ranked tenth). In adolescents aged 10–24 years, three injury causes were among the top causes of DALYs: road injuries (ranked first), self-harm (third), and interpersonal violence (fifth). Five of the causes that were in the top ten for ages 10–24 years were also in the top ten in the 25–49-year age group: road injuries (ranked first), HIV/AIDS (second), low back pain (fourth), headache disorders (fifth), and depressive disorders (sixth). In 2019, ischaemic heart disease and stroke were the top-ranked causes of DALYs in both the 50–74-year and 75-years-and-older age groups. Since 1990, there has been a marked shift towards a greater proportion of burden due to YLDs from non-communicable diseases and injuries. In 2019, there were 11 countries where non-communicable disease and injury YLDs constituted more than half of all disease burden. Decreases in age-standardised DALY rates have accelerated over the past decade in countries at the lower end of the SDI range, while improvements have started to stagnate or even reverse in countries with higher SDI. Interpretation: As disability becomes an increasingly large component of disease burden and a larger component of health expenditure, greater research and developm nt investment is needed to identify new, more effective intervention strategies. With a rapidly ageing global population, the demands on health services to deal with disabling outcomes, which increase with age, will require policy makers to anticipate these changes. The mix of universal and more geographically specific influences on health reinforces the need for regular reporting on population health in detail and by underlying cause to help decision makers to identify success stories of disease control to emulate, as well as opportunities to improve. Funding: Bill & Melinda Gates Foundation. © 2020 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 licens
Global, regional, and national disability-adjusted life-years (DALYs) for 359 diseases and injuries and healthy life expectancy (HALE) for 195 countries and territories, 1990-2017: a systematic analysis for the Global Burden of Disease Study 2017.
- Author
- Abate Degu
- Abate Kalkidan Hassen
- Abay Solomon M
- Abbafati Cristiana
- Abbasi Nooshin
- Abbastabar Hedayat
- Abd-Allah Foad
- Abdela Jemal
- Abdelalim Ahmed
- Abdollahpour Ibrahim
- Abdulkader Rizwan Suliankatchi
- Abebe Molla
- Abebe Zegeye
- Abil Olifan Zewdie
- Aboyans Victor
- Abrham Aklilu Roba
- Abu-Raddad Laith Jamal
- Abu-Rmeileh Niveen M E
- Accrombessi Manfred Mario Kokou
- Acharya Dilaram
- Acharya Pawan
- Ackerman Ilana N
- Adamu Abdu A
- Adebayo Oladimeji M
- Adekanmbi Victor
- Ademi Zanfina
- Adetokunboh Olatunji O
- Adib Mina G
- Adsuar Jose C
- Afanvi Kossivi Agbelenko
- Afarideh Mohsen
- Afshin Ashkan
- Agarwal Gina
- Agesa Kareha M
- Aggarwal Rakesh
- Aghayan Sargis Aghasi
- Agrawal Anurag
- Ahmadi Alireza
- Ahmadi Mehdi
- Ahmadieh Hamid
- Ahmed Muktar Beshir
- Ahmed Sayem
- Aichour Amani Nidhal
- Aichour Ibtihel
- Aichour Miloud Taki Eddine
- Akinyemiju Tomi
- Akseer Nadia
- Al-Aly Ziyad
- Al-Eyadhy Ayman
- Al-Mekhlafi Hesham M
- Al-Raddadi Rajaa M
- Alahdab Fares
- Alam Khurshid
- Alam Tahiya
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- Alavian Seyed Moayed
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- Alijanzadeh Mehran
- Alizadeh-Navaei Reza
- Aljunid Syed Mohamed
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- Schutte Aletta Elisabeth
- Schwebel David C
- Schwendicke Falk
- Scott James G
- Sekerija Mario
- Sepanlou Sadaf G
- Serván-Mori Edson
- Seyedmousavi Seyedmojtaba
- Shabaninejad Hosein
- Shafieesabet Azadeh
- Shahbazi Mehdi
- Shaheen Amira A
- Shaikh Masood Ali
- Shams-Beyranvand Mehran
- Shamsi Mohammadbagher
- Sharafi Heidar
- Sharafi Kiomars
- Sharif Mehdi
- Sharif-Alhoseini Mahdi
- Sharma Jayendra
- Sharma Rajesh
- She Jun
- Sheikh Aziz
- Shi Peilin
- Shiadeh Malihe Nourollahpour
- Shibuya Kenji
- Shiferaw Mekonnen Sisay
- Shigematsu Mika
- Shiri Rahman
- Shirkoohi Reza
- Shiue Ivy
- Shokoohinia Yalda
- Shokraneh Farhad
- Shoman Haitham
- Shrime Mark G
- Si Si
- Siabani Soraya
- Sibai Abla Mehio
- Siddiqi Tariq J
- Sigfusdottir Inga Dora
- Sigurvinsdottir Rannveig
- Silva Diego Augusto Santos
- Silva João Pedro
- Silveira Dayane Gabriele Alves
- Singam Narayana Sarma Venkata
- Singh Jasvinder A
- Singh Narinder Pal
- Singh Virendra
- Sinha Dhirendra Narain
- Skiadaresi Eirini
- Skirbekk Vegard
- Sliwa Karen
- Smith David L
- Smith Mari
- Soares Filho Adauto Martins
- Sobaih Badr Hasan
- Sobhani Soheila
- Soofi Moslem
- Sorensen Reed J D
- Soyiri Ireneous N
- Sposato Luciano A
- Sreeramareddy Chandrashekhar T
- Srinivasan Vinay
- Stanaway Jeffrey D
- Starodubov Vladimir I
- Stein Dan J
- Steiner Caitlyn
- Steiner Timothy J
- Stokes Mark A
- Stovner Lars Jacob
- Subart Michelle L
- Sudaryanto Agus
- Sufiyan Mu'awiyyah Babale
- Sulo Gerhard
- Sunguya Bruno F
- Sur Patrick John
- Sykes Bryan L
- Sylaja P N
- Sylte Dillon O
- Szoeke Cassandra E I
- Tabarés-Seisdedos Rafael
- Tabuchi Takahiro
- Tadakamadla Santosh Kumar
- Tandon Nikhil
- Tassew Segen Gebremeskel
- Tavakkoli Mohammad
- Taveira Nuno
- Taylor Hugh R
- Tehrani-Banihashemi Arash
- Tekalign Tigist Gashaw
- Tekelemedhin Shishay Wahdey
- Tekle Merhawi Gebremedhin
- Temsah Mohamad-Hani
- Temsah Omar
- Terkawi Abdullah Sulieman
- Tessema Belay
- Teweldemedhin Mebrahtu
- Thankappan Kavumpurathu Raman
- Theis Andrew
- Thirunavukkarasu Sathish
- Thomas Nihal
- Tilahun Binyam
- To Quyen G
- Tonelli Marcello
- Topor-Madry Roman
- Torre Anna E
- Tortajada-Girbés Miguel
- Touvier Mathilde
- Tovani-Palone Marcos Roberto
- Towbin Jeffrey A
- Tran Bach Xuan
- Tran Khanh Bao
- Troeger Christopher E
- Tsadik Afewerki Gebremeskel
- Tsoi Derrick
- Tudor Car Lorainne
- Tyrovolas Stefanos
- Ukwaja Kingsley Nnanna
- Ullah Irfan
- Undurraga Eduardo A
- Updike Rachel L
- Usman Muhammad Shariq
- Uthman Olalekan A
- Vaduganathan Muthiah
- Vaezi Afsane
- Valdez Pascual R
- Varavikova Elena
- Varughese Santosh
- Vasankari Tommi Juhani
- Venketasubramanian Narayanaswamy
- Villafaina Santos
- Violante Francesco S
- Vladimirov Sergey Konstantinovitch
- Vlassov Vasily
- Vollset Stein Emil
- Vos Theo
- Vosoughi Kia
- Vujcic Isidora S
- Wagnew Fasil Shiferaw
- Waheed Yasir
- Wang Yafeng
- Wang Yuan-Pang
- Weiderpass Elisabete
- Weintraub Robert G
- Weiss Daniel J
- Weldegebreal Fitsum
- Weldegwergs Kidu Gidey
- Werdecker Andrea
- West T Eoin
- Westerman Ronny
- Whiteford Harvey A
- Widecka Justyna
- Wijeratne Tissa
- Williams Hywel C
- Wilner Lauren B
- Wilson Shadrach
- Winkler Andrea Sylvia
- Wiyeh Alison B
- Wiysonge Charles Shey
- Wolfe Charles D A
- Woolf Anthony D
- Wyper Grant M A
- Xavier Denis
- Xu Gelin
- Yadgir Simon
- Yahyazadeh Jabbari Seyed Hossein
- Yamada Tomohide
- Yan Lijing L
- Yano Yuichiro
- Yaseri Mehdi
- Yasin Yasin Jemal
- Yeshaneh Alex
- Yimer Ebrahim M
- Yip Paul
- Yisma Engida
- Yonemoto Naohiro
- Yoon Seok-Jun
- Yotebieng Marcel
- Younis Mustafa Z
- Yousefifard Mahmoud
- Yu Chuanhua
- Zadnik Vesna
- Zaidi Zoubida
- Zaman Sojib Bin
- Zamani Mohammad
- Zandian Hamed
- Zar Heather J
- Zenebe Zerihun Menlkalew
- Zhou Maigeng
- Zipkin Ben
- Zodpey Sanjay
- Zucker Inbar
- Zuhlke Liesl Joanna
- Ärnlöv Johan
- Øverland Simon
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2018
- Field of study
How long one lives, how many years of life are spent in good and poor health, and how the population's state of health and leading causes of disability change over time all have implications for policy, planning, and provision of services. We comparatively assessed the patterns and trends of healthy life expectancy (HALE), which quantifies the number of years of life expected to be lived in good health, and the complementary measure of disability-adjusted life-years (DALYs), a composite measure of disease burden capturing both premature mortality and prevalence and severity of ill health, for 359 diseases and injuries for 195 countries and territories over the past 28 years. Methods We used data for age-specific mortality rates, years of life lost (YLLs) due to premature mortality, and years lived with disability (YLDs) from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2017 to calculate HALE and DALYs from 1990 to 2017. We calculated HALE using age-specific mortality rates and YLDs per capita for each location, age, sex, and year. We calculated DALYs for 359 causes as the sum of YLLs and YLDs. We assessed how observed HALE and DALYs differed by country and sex from expected trends based on Socio-demographic Index (SDI). We also analysed HALE by decomposing years of life gained into years spent in good health and in poor health, between 1990 and 2017, and extra years lived by females compared with males. Findings Globally, from 1990 to 2017, life expectancy at birth increased by 7·4 years (95% uncertainty interval 7·1-7·8), from 65·6 years (65·3-65·8) in 1990 to 73·0 years (72·7-73·3) in 2017. The increase in years of life varied from 5·1 years (5·0-5·3) in high SDI countries to 12·0 years (11·3-12·8) in low SDI countries. Of the additional years of life expected at birth, 26·3% (20·1-33·1) were expected to be spent in poor health in high SDI countries compared with 11·7% (8·8-15·1) in low-middle SDI countries. HALE at birth increased by 6·3 years (5·9-6·7), from 57·0 years (54·6-59·1) in 1990 to 63·3 years (60·5-65·7) in 2017. The increase varied from 3·8 years (3·4-4·1) in high SDI countries to 10·5 years (9·8-11·2) in low SDI countries. Even larger variations in HALE than these were observed between countries, ranging from 1·0 year (0·4-1·7) in Saint Vincent and the Grenadines (62·4 years [59·9-64·7] in 1990 to 63·5 years [60·9-65·8] in 2017) to 23·7 years (21·9-25·6) in Eritrea (30·7 years [28·9-32·2] in 1990 to 54·4 years [51·5-57·1] in 2017). In most countries, the increase in HALE was smaller than the increase in overall life expectancy, indicating more years lived in poor health. In 180 of 195 countries and territories, females were expected to live longer than males in 2017, with extra years lived varying from 1·4 years (0·6-2·3) in Algeria to 11·9 years (10·9-12·9) in Ukraine. Of the extra years gained, the proportion spent in poor health varied largely across countries, with less than 20% of additional years spent in poor health in Bosnia and Herzegovina, Burundi, and Slovakia, whereas in Bahrain all the extra years were spent in poor health. In 2017, the highest estimate of HALE at birth was in Singapore for both females (75·8 years [72·4-78·7]) and males (72·6 years [69·8-75·0]) and the lowest estimates were in Central African Republic (47·0 years [43·7-50·2] for females and 42·8 years [40·1-45·6] for males). Globally, in 2017, the five leading causes of DALYs were neonatal disorders, ischaemic heart disease, stroke, lower respiratory infections, and chronic obstructive pulmonary disease. Between 1990 and 2017, age-standardised DALY rates decreased by 41·3% (38·8-43·5) for communicable diseases and by 49·8% (47·9-51·6) for neonatal disorders. For non-communicable diseases, global DALYs increased by 40·1% (36·8-43·0), although age-standardised DALY rates decreased by 18·1% (16·0-20·2)
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