Integración europea y opinión pública en el sur de Europa: un análisis del eurooptimismo

Este trabajo se centra en el análisis de la opinión pública hacia la integración Europea en Grecia,Portugal y España, países caracterizados por los altos niveles de eurooptimismo. En particular, el textoexamina los condicionantes de las actitudes positivas de los ciudadanos, a partir de las explicacionesofrecidas por la literatura, e indaga sobre el diferente impacto que determinadas variables ejercen sobreel eurooptimismo. Los hallazgos ponen de manifiesto, por un lado, la relevancia de variables de tipoidentitario, frente a las de naturaleza económica y, por otro, en qué contextos las pistas partidistas y laideología tienen potencial predictivo en las actitudes de apoyo genérico a la integración

Partidos políticos versus presidentes. Uma análise da congruência ideológica na América Latina

This study aims the political congruence in Latin American presidentialist democracies. It analyzes the levels of ideological congruence between parties and presidential candidates with their voters. The data used come from Americas Barometer at Vanderbilt University and Latin American Elites Project at the University of Salamanca for 11 Latin American countries between 2004 and 2014. The results conclude that the ideological links in Latin America are varied. Voters tend to be more congruent with the political parties they vote for in the legislative than with the candidates they vote for president, reinforcing the idea of dual legitimacy and dual representation in these countries. The radicalism, and the number, of parties and candidates appears as the most significant variables to explain ideological congruence.Este estudio apunta a la congruencia política en las democracias presidenciales latinoamericanas. Analiza los niveles de congruencia ideológica entre los partidos y los candidatos presidenciales con sus votantes. Los datos utilizados provienen del Barómetro de las Américas en la Universidad de Vanderbilt y del Proyecto de las Élites Latinoamericanas en la Universidad de Salamanca para 11 países latinoamericanos entre 2004 y 2014. Los resultados concluyen que los vínculos ideológicos en América Latina son variados. Los votantes tienden a ser más congruentes con los partidos políticos por los que votan en el legislativo que con los candidatos que votan por el presidente, lo que refuerza la idea de doble legitimidad y doble representación en estos países. El radicalismo y el número de partidos y candidatos aparecen como las variables más significativas para explicar la congruencia ideológica.Este estudo analisa a congruência política nas democracias presidencialistas da América Latina. Ele analisa os níveis de congruência ideológica entre partidos e candidatos à presidência com seus eleitores. Os dados utilizados são do Barômetro das Américas da Universidade de Vanderbilt e do Projeto de Elites da América Latina da Universidade de Salamanca para 11 países da América Latina entre 2004 e 2014. Os resultados concluem que os vínculos ideológicos na América Latina são variados. Os eleitores tendem a ser mais congruentes com os partidos políticos em que votam no legislativo do que com os candidatos que votam para presidente, reforçando a idéia de dupla legitimidade e dupla representação nesses países. O radicalismo e o número de partidos e candidatos aparecem como as variáveis mais significativas para explicar a congruência ideológica

Ideological proximity in the presidential elections of Costa Rica, El Salvador and Honduras

In this article we test the theory of proximity voting in the most recent presidential elections of three Central American countries: Costa Rica, El Salvador and Honduras. For this purpose, we specified Mixed Mutinomial Probit models and found that ideological proximity had a relevant effect on voters’ choices. Moreover, the ideological distance between those citizens and the candidates affected the latter differently, depending on the partisan context in which they were competing.En este artículo contrastamos la teoría del voto por proximidad ideológica en las más recientes elecciones presidenciales de tres países centroamericanos: Costa Rica, El Salvador y Honduras. Para tal efecto especificamos modelos Probit Mutinomiales Mixtos, a partir de los cuales encontramos que la cercanía ideológica tuvo un efecto relevante en dichas elecciones. La distancia entre votantes y candidatos afectó de manera diferente a estos últimos, dependiendo del contexto partidista en que competían

Clientelism and ideological competition: the impact on ideological overlapping

Clientelism is a widespread and persistent practice in Latin America with significant ramifications for political actors and systems. This paper analyses its impact upon ideological overlapping, which is one of the aspects of ideological competition that has received disparate levels of attention depending on the region of study. The hypothesis examined is that clientelism reduces the ideological differentiation of political parties because, firstly, a clientelist environment makes it difficult for political actors to use left/right categories, thereby contributing to a reduction in parties’ ideological identities. Secondly, the use of clientelist practices by parties fosters ideological overlapping with other parties, given the lack of incentives for them to differentiate themselves ideologically from one another. To test this relationship, a multilevel regression analysis was performed of 86 Latin American parties since 2009.Depto. de Ciencia Política y de la AdministraciónFac. de Ciencias Políticas y SociologíaTRUEpu

Sleep Disturbance, Psychological Distress and Perceived Burden in Female Family Caregivers of Dependent Patients with Dementia: A Case-Control Study

[Abstract] This case-control study analyzed the sleep disturbance, psychological distress and perceived burden in female family caregivers of dependent people with dementia (n = 74) compared with female family caregivers of dependent people without dementia (n = 74) and with age-matched non-caregiver control females (n = 74). Participants completed the Pittsburgh Sleep Quality Index (PSQI), the 12-item General Health Questionnaire (GHQ-12), the Caregiver Burden Inventory (CBI) and an ad hoc questionnaire to collect sociodemographic data. There were significant differences between the groups in PSQI total (F = 24.93; p < 0.001), psychological distress (F = 26.71; p < 0.001) and in all sleep domains assessed: subjective sleep quality (F = 16.19; p < 0.001), sleep latency (F = 9.5; p< 0.001), sleep duration (F = 18.57; p < 0.001), habitual sleep efficiency (F = 19.77; p < 0.001), sleep disturbances (F = 9.22; p < 0.001), use of sleep medications (F = 4.24; p< 0.01) and daytime dysfunction (F = 5.57; p < 0.01). In all measures, the female family caregivers of dependent people with dementia showed the significantly higher mean scores. Regarding the two groups of female caregivers, statistically significant differences were found in daily hours of care (t = −2.45; p < 0.05) and perceived burden (t = −3.65; p < 0.001), as well as in the following dimensions of caregiver burden: time-dependence burden (t = −5.09; p < 0.001), developmental burden (t = −2.42; p < 0.05) and physical burden (t = −2.89; p < 0.01). These findings suggest that female family caregivers of dependent patients with dementia should be subject to psychopathological screening and preventive cognitive-behavioral interventions in clinical practice in primary health care.Universidade de Santiago de Compostela; 2022-CE081-1

Prevalence of sleep complaints in Colombia at different altitudes

AbstractStudy objectivesTo determine the prevalence of sleep complaints in adults in Colombia at different altitudes.DesignCross-sectional, population-based and observational study.SettingUrban areas in three cities (Bogotá, Bucaramanga, Santa Marta) located between 15 and 2640 masl. Subjects Over 18 years old.InterventionsEpworth sleepiness scale (ESS), Pittsburgh sleep quality index (PSQI), Berlin questionnaire, STOP-Bang questionnaire and diagnostic criteria for restless leg syndrome (IRLSSG).Measurements and resultsThe overall prevalence of sleep complaints was 59.6% (CI 95%: 57.3; 61.8%). According to the Pittsburgh scale, 45.3% (CI 95%: 43.0; 47.5) required medical assistance. The Berlin questionnaire indicated that 19.0% (CI 95%: 17.3; 20.8%) had a high risk of sleep apnea (OSA) compared to 26.9% (CI 95%: 24.9; 29.0%) according to STOP-Bang. Among the subjects, 13.7% (CI 95%: 12.3; 15.3%) had excessive daytime sleepiness and 37.7% (CI 95%: 35.5; 39.8%) had a restless leg syndrome. When comparing cities, significant differences in the overall frequency of subjects requiring care were found between Santa Marta (higher frequency) and the other two cities. Differences in sleep problem frequency (Pittsburgh) were observed between Bogota (higher frequency) and Bucaramanga and also between Santa Marta (higher frequency) and the other two cities. The high risk of OSA (STOP-Bang) was different between Bogota (higher frequency) and Bucaramanga and also between Santa Marta (high frequency) and Bucaramanga.ConclusionsWe observed a high prevalence of sleep complaints with significant differences among the cities, indicating a need to pay a greater attention to these problems

CAR density influences antitumoral efficacy of BCMA CAR T cells and correlates with clinical outcome

Identification of new markers associated with long-term efficacy in patients treated with CAR T cells is a current medical need, particularly in diseases such as multiple myeloma. In this study, we address the impact of CAR density on the functionality of BCMA CAR T cells. Functional and transcriptional studies demonstrate that CAR T cells with high expression of the CAR construct show an increased tonic signaling with up-regulation of exhaustion markers and increased in vitro cytotoxicity but a decrease in in vivo BM infiltration. Characterization of gene regulatory networks using scRNA-seq identified regulons associated to activation and exhaustion up-regulated in CARHigh T cells, providing mechanistic insights behind differential functionality of these cells. Last, we demonstrate that patients treated with CAR T cell products enriched in CARHigh T cells show a significantly worse clinical response in several hematological malignancies. In summary, our work demonstrates that CAR density plays an important role in CAR T activity with notable impact on clinical response

Preclinical models for prediction of immunotherapy outcomes and immune evasion mechanisms in genetically heterogeneous multiple myeloma

The historical lack of preclinical models reflecting the genetic heterogeneity of multiple myeloma (MM) hampers the advance of therapeutic discoveries. To circumvent this limitation, we screened mice engineered to carry eight MM lesions (NF-κB, KRAS, MYC, TP53, BCL2, cyclin D1, MMSET/NSD2 and c-MAF) combinatorially activated in B lymphocytes following T cell-driven immunization. Fifteen genetically diverse models developed bone marrow (BM) tumors fulfilling MM pathogenesis. Integrative analyses of ∼500 mice and ∼1,000 patients revealed a common MAPK-MYC genetic pathway that accelerated time to progression from precursor states across genetically heterogeneous MM. MYC-dependent time to progression conditioned immune evasion mechanisms that remodeled the BM microenvironment differently. Rapid MYC-driven progressors exhibited a high number of activated/exhausted CD8+ T cells with reduced immunosuppressive regulatory T (Treg) cells, while late MYC acquisition in slow progressors was associated with lower CD8+ T cell infiltration and more abundant Treg cells. Single-cell transcriptomics and functional assays defined a high ratio of CD8+ T cells versus Treg cells as a predictor of response to immune checkpoint blockade (ICB). In clinical series, high CD8+ T/Treg cell ratios underlie early progression in untreated smoldering MM, and correlated with early relapse in newly diagnosed patients with MM under Len/Dex therapy. In ICB-refractory MM models, increasing CD8+ T cell cytotoxicity or depleting Treg cells reversed immunotherapy resistance and yielded prolonged MM control. Our experimental models enable the correlation of MM genetic and immunological traits with preclinical therapy responses, which may inform the next-generation immunotherapy trials

Leer en comunidad: Creación y desarrollo de clubes de lectura dentro y fuera de la Universidad

Depto. de Lengua Española y Teoría de la LiteraturaFac. de FilologíaFALSEsubmitte

Repositioning of the global epicentre of non-optimal cholesterol

High blood cholesterol is typically considered a feature of wealthy western countries(1,2). However, dietary and behavioural determinants of blood cholesterol are changing rapidly throughout the world(3) and countries are using lipid-lowering medications at varying rates. These changes can have distinct effects on the levels of high-density lipoprotein (HDL) cholesterol and non-HDL cholesterol, which have different effects on human health(4,5). However, the trends of HDL and non-HDL cholesterol levels over time have not been previously reported in a global analysis. Here we pooled 1,127 population-based studies that measured blood lipids in 102.6 million individuals aged 18 years and older to estimate trends from 1980 to 2018 in mean total, non-HDL and HDL cholesterol levels for 200 countries. Globally, there was little change in total or non-HDL cholesterol from 1980 to 2018. This was a net effect of increases in low- and middle-income countries, especially in east and southeast Asia, and decreases in high-income western countries, especially those in northwestern Europe, and in central and eastern Europe. As a result, countries with the highest level of non-HDL cholesterol-which is a marker of cardiovascular riskchanged from those in western Europe such as Belgium, Finland, Greenland, Iceland, Norway, Sweden, Switzerland and Malta in 1980 to those in Asia and the Pacific, such as Tokelau, Malaysia, The Philippines and Thailand. In 2017, high non-HDL cholesterol was responsible for an estimated 3.9 million (95% credible interval 3.7 million-4.2 million) worldwide deaths, half of which occurred in east, southeast and south Asia. The global repositioning of lipid-related risk, with non-optimal cholesterol shifting from a distinct feature of high-income countries in northwestern Europe, north America and Australasia to one that affects countries in east and southeast Asia and Oceania should motivate the use of population-based policies and personal interventions to improve nutrition and enhance access to treatment throughout the world.Peer reviewe