Liver-related events and mortality among elderly patients with advanced chronic hepatitis C treated with direct-acting antivirals

BACKGROUND: Direct-acting antivirals (DAAs) are effective in patients aged >/=65 years. However, little is known about the effects of DAAs on survival, liver decompensation and development of hepatocellular carcinoma (HCC). OBJECTIVE: To compare the incidence of liver-related events and mortality between patients aged >/=65 and /=65 and /=65 and 380 aged /=65 years treated with DAAs seems to be secondary to non-liver-related causes. These results support the utilization of DAAs in patients aged >/=65 years

A wide deep infrared look at the Pleiades with UKIDSS: new constraints on the substellar binary fraction and the low mass IMF

We present the results of a deep wide-field near-infrared survey of 12 square degrees of the Pleiades conducted as part of the UKIDSS Deep Infrared Sky Survey (UKIDSS) Galactic Cluster Survey (GCS). We have extracted over 340 high probability proper motion members down to 0.03 solar masses using a combination of UKIDSS photometry and proper motion measurements obtained by cross-correlating the GCS with data from the Two Micron All Sky Survey (2MASS), the Isaac Newton (INT) and the Canada-France-Hawai'i (CFHT) telescopes. Additionally, we have unearthed 73 new candidate brown dwarf members on the basis of five band UKIDSS photometry alone. We have identified 23 substellar multiple system candidates out of 63 candidate brown dwarfs from the (Y-K,Y) and (J-K,J) colour-magnitude diagrams, yielding a binary frequency of 28-44% in the 0.075-0.030 Msun mass range. Our estimate is three times larger than the binary fractions reported from high-resolution imaging surveys of field ultracool dwarfs and Pleiades brown dwarfs. However, it is marginally consistent with our earlier ``peculiar'' photometric binary fraction of 50+/-10% presented in Pinfield et al. (2003), in good agreement with the 32-45% binary fraction derived from the recent Monte-Carlo simulations of Maxted & Jeffries (2005) and compatible with the 26+/-10% frequency recently estimated by Basri & Reiners (2006). A tentative estimate of the mass ratios from photometry alone seems to support the hypothesis that binary brown dwarfs tend to reside in near equal-mass ratio systems. (abridged)Comment: 21 pages, 8 figures, 6 tables, 1 electronic table, 6 appendices with tables, accepted to MNRA

Catalog for the ESPRESSO blind radial velocity exoplanet survey

One of the main scientific drivers for ESPRESSO,\'Echelle SPectrograph, is the detection and characterization of Earth-class exoplanets. With this goal in mind, the ESPRESSO Guaranteed Time Observations (GTO) Catalog identifies the best target stars for a blind search for the radial velocity (RV) signals caused by Earth-class exoplanets. Using the most complete stellar catalogs available, we screened for the most suitable G, K, and M dwarf stars for the detection of Earth-class exoplanets with ESPRESSO. For most of the stars, we then gathered high-resolution spectra from new observations or from archival data. We used these spectra to spectroscopically investigate the existence of any stellar binaries, both bound or background stars. We derived the activity level using chromospheric activity indexes using $log(R'_{HK})$, as well as the projected rotational velocity $\textit{v sin i}$. For the cases where planet companions are already known, we also looked at the possibility that additional planets may exist in the host's habitable zone using dynamical arguments. We estimated the spectroscopic contamination level, $\textit{v sin i}$, activity, stellar parameters and chemical abundances for 249 of the most promising targets. Using these data, we selected 45 stars that match our criteria for detectability of a planet like Earth. The stars presented and discussed in this paper constitute the ESPRESSO GTO catalog for the RV blind search for Earth-class planets. They can also be used for any other work requiring a detailed spectroscopic characterization of stars in the solar neighborhood.Comment: Corrected a typo in references. Corrected typo in table B.

A deep wide-field optical survey in the young open cluster Collinder 359

We present the first deep, optical, wide-field imaging survey of the young open cluster Collinder 359, complemented by near-infrared follow-up observations. This study is part of a large programme aimed at examining the dependence of the mass function on environment and time. We have surveyed 1.6 square degrees in the cluster, in the I and z filters, with the CFH12K camera on the Canada-France-Hawaii 3.6-m telescope down to completeness and detection limits in both filters of 22.0 and 24.0 mag, respectively. Based on their location in the optical (I-z,I) colour-magnitude diagram, we have extracted new cluster member candidates in Collinder 359 spanning 1.3-0.03 Msun assuming an age of 60 Myr and a distance of 450 pc for the cluster. We have used the 2MASS database as well as our own near-infrared photometry to examine the membership status of the optically-selected cluster candidates. Comparison of the location of the most massive members in Collinder 359 in a (B-V,V) diagram with theoretical isochrones suggests that Collinder 359 is older than Alpha Per but younger than the Pleiades. We discuss the possible relationship between Collinder 359 and IC 4665 as both clusters harbour similar parameters, including proper motion, distance, and age.Comment: 13 pages, 9 figures, 4 tables, Table 4 only available in electronic format, accepted for publication in A&A on 30 Dec 200

Exploring the Lower Mass Function in the young open Cluster IC 4665

We present a study of the young (30-100Myr) open cluster IC 4665 with the aim to determine the shape of the mass function well into the brown dwarf regime. We photometrically select 691 low-mass stellar and 94 brown dwarf candidate members over an area of 3.82 square degrees centred on the cluster. K-band follow-up photometry and Two-Micron All-Sky Survey data allow a first filtering of contaminant objects from our catalogues. A second filtering is performed for the brightest stars using proper motion data provided by the Tycho-2 and UCAC2 public catalogues. Contamination by the field population for the lowest mass objects is estimated using same latitude control fields. We fit observed surface densities of various cluster populations with King profiles and find a consistent tidal radius of 1.0 degree. The presence of possible mass segregation is discussed. In most respects investigated, IC 4665 is similar to other young open clusters at this age: (1) a power law fit to the mass function between 1 and 0.04Msun results in best fit for a slope of -0.6; (2) a cusp in the mass function is noticed at about the substellar boundary with respect to the power law description, the interpretation of which is discussed; (3) a fraction between 10-19% for BDs with M > 0.03Msun to total members; (4) a best-fit lognormal function to the full mass distribution shows an average member mass of 0.32Msun, if IC 4665 has an age of 50Myr.Comment: 14 pages, 13 figures. Accepted for publication in A&A. Catalogue with candidate members at CD

Search for the standard model Higgs boson in the H to ZZ to 2l 2nu channel in pp collisions at sqrt(s) = 7 TeV

A search for the standard model Higgs boson in the H to ZZ to 2l 2nu decay channel, where l = e or mu, in pp collisions at a center-of-mass energy of 7 TeV is presented. The data were collected at the LHC, with the CMS detector, and correspond to an integrated luminosity of 4.6 inverse femtobarns. No significant excess is observed above the background expectation, and upper limits are set on the Higgs boson production cross section. The presence of the standard model Higgs boson with a mass in the 270-440 GeV range is excluded at 95% confidence level.Comment: Submitted to JHE

Azimuthal anisotropy of charged particles at high transverse momenta in PbPb collisions at sqrt(s[NN]) = 2.76 TeV

The azimuthal anisotropy of charged particles in PbPb collisions at nucleon-nucleon center-of-mass energy of 2.76 TeV is measured with the CMS detector at the LHC over an extended transverse momentum (pt) range up to approximately 60 GeV. The data cover both the low-pt region associated with hydrodynamic flow phenomena and the high-pt region where the anisotropies may reflect the path-length dependence of parton energy loss in the created medium. The anisotropy parameter (v2) of the particles is extracted by correlating charged tracks with respect to the event-plane reconstructed by using the energy deposited in forward-angle calorimeters. For the six bins of collision centrality studied, spanning the range of 0-60% most-central events, the observed v2 values are found to first increase with pt, reaching a maximum around pt = 3 GeV, and then to gradually decrease to almost zero, with the decline persisting up to at least pt = 40 GeV over the full centrality range measured.Comment: Replaced with published version. Added journal reference and DO

<i>Gaia</i> Data Release 1. Summary of the astrometric, photometric, and survey properties

Context. At about 1000 days after the launch of Gaia we present the first Gaia data release, Gaia DR1, consisting of astrometry and photometry for over 1 billion sources brighter than magnitude 20.7. Aims. A summary of Gaia DR1 is presented along with illustrations of the scientific quality of the data, followed by a discussion of the limitations due to the preliminary nature of this release. Methods. The raw data collected by Gaia during the first 14 months of the mission have been processed by the Gaia Data Processing and Analysis Consortium (DPAC) and turned into an astrometric and photometric catalogue. Results. Gaia DR1 consists of three components: a primary astrometric data set which contains the positions, parallaxes, and mean proper motions for about 2 million of the brightest stars in common with the HIPPARCOS and Tycho-2 catalogues – a realisation of the Tycho-Gaia Astrometric Solution (TGAS) – and a secondary astrometric data set containing the positions for an additional 1.1 billion sources. The second component is the photometric data set, consisting of mean G-band magnitudes for all sources. The G-band light curves and the characteristics of ∼3000 Cepheid and RR-Lyrae stars, observed at high cadence around the south ecliptic pole, form the third component. For the primary astrometric data set the typical uncertainty is about 0.3 mas for the positions and parallaxes, and about 1 mas yr−1 for the proper motions. A systematic component of ∼0.3 mas should be added to the parallax uncertainties. For the subset of ∼94 000 HIPPARCOS stars in the primary data set, the proper motions are much more precise at about 0.06 mas yr−1. For the secondary astrometric data set, the typical uncertainty of the positions is ∼10 mas. The median uncertainties on the mean G-band magnitudes range from the mmag level to ∼0.03 mag over the magnitude range 5 to 20.7. Conclusions. Gaia DR1 is an important milestone ahead of the next Gaia data release, which will feature five-parameter astrometry for all sources. Extensive validation shows that Gaia DR1 represents a major advance in the mapping of the heavens and the availability of basic stellar data that underpin observational astrophysics. Nevertheless, the very preliminary nature of this first Gaia data release does lead to a number of important limitations to the data quality which should be carefully considered before drawing conclusions from the data

Measurement of the t t-bar production cross section in the dilepton channel in pp collisions at sqrt(s) = 7 TeV

The t t-bar production cross section (sigma[t t-bar]) is measured in proton-proton collisions at sqrt(s) = 7 TeV in data collected by the CMS experiment, corresponding to an integrated luminosity of 2.3 inverse femtobarns. The measurement is performed in events with two leptons (electrons or muons) in the final state, at least two jets identified as jets originating from b quarks, and the presence of an imbalance in transverse momentum. The measured value of sigma[t t-bar] for a top-quark mass of 172.5 GeV is 161.9 +/- 2.5 (stat.) +5.1/-5.0 (syst.) +/- 3.6(lumi.) pb, consistent with the prediction of the standard model.Comment: Replaced with published version. Included journal reference and DO

Performance of CMS muon reconstruction in pp collision events at sqrt(s) = 7 TeV

The performance of muon reconstruction, identification, and triggering in CMS has been studied using 40 inverse picobarns of data collected in pp collisions at sqrt(s) = 7 TeV at the LHC in 2010. A few benchmark sets of selection criteria covering a wide range of physics analysis needs have been examined. For all considered selections, the efficiency to reconstruct and identify a muon with a transverse momentum pT larger than a few GeV is above 95% over the whole region of pseudorapidity covered by the CMS muon system, abs(eta) < 2.4, while the probability to misidentify a hadron as a muon is well below 1%. The efficiency to trigger on single muons with pT above a few GeV is higher than 90% over the full eta range, and typically substantially better. The overall momentum scale is measured to a precision of 0.2% with muons from Z decays. The transverse momentum resolution varies from 1% to 6% depending on pseudorapidity for muons with pT below 100 GeV and, using cosmic rays, it is shown to be better than 10% in the central region up to pT = 1 TeV. Observed distributions of all quantities are well reproduced by the Monte Carlo simulation.Comment: Replaced with published version. Added journal reference and DO