64 research outputs found
High-Throughput Sequencing of mGluR Signaling Pathway Genes Reveals Enrichment of Rare Variants in Autism
- Author
- B Conne
- B John
- B Li
- B Xiao
- Barbara Rathmell
- BJ O'Roak
- BS Abrahams
- C Nava
- C Sala
- CM Durand
- CP Schaaf
- D Abankwa
- D Ehninger
- D Levy
- D Pinto
- D Sayed
- David Margulies
- DH Geschwind
- Edwin Trautman
- FF Hamdan
- Francisco José Esteban
- G Dolen
- G Rumbaugh
- Hayk Hovhannisyan
- IA Adzhubei
- J Sebat
- J Thusberg
- JA Ronesi
- JA Ronesi
- JD Sweatt
- JF Abelson
- JM Chen
- JT Glessner
- Kelleher RJ 3rd
- Kelleher RJ 3rd
- LA Weiss
- M Wiznitzer
- MB Ramocki
- MF Bear
- MK Hayashi
- P El-Fishawy
- P Szatmari
- PC Ng
- PL Greer
- R Calabrese
- R Toro
- Randall Carpenter
- Raymond J. Kelleher III
- RM Costa
- Robert Pinard
- S Berkel
- S Griffiths-Jones
- S Jamain
- SJ Sanders
- SM Gallagher
- SR Gilman
- TC Sudhof
- Ute Geigenmüller
- X Gai
- X Zhao
- Y Aoki
- Publication venue
- Public Library of Science
- Publication date
- 27/04/2012
- Field of study
Identification of common molecular pathways affected by genetic variation in autism is important for understanding disease pathogenesis and devising effective therapies. Here, we test the hypothesis that rare genetic variation in the metabotropic glutamate-receptor (mGluR) signaling pathway contributes to autism susceptibility. Single-nucleotide variants in genes encoding components of the mGluR signaling pathway were identified by high-throughput multiplex sequencing of pooled samples from 290 non-syndromic autism cases and 300 ethnically matched controls on two independent next-generation platforms. This analysis revealed significant enrichment of rare functional variants in the mGluR pathway in autism cases. Higher burdens of rare, potentially deleterious variants were identified in autism cases for three pathway genes previously implicated in syndromic autism spectrum disorder, TSC1, TSC2, and SHANK3, suggesting that genetic variation in these genes also contributes to risk for non-syndromic autism. In addition, our analysis identified HOMER1, which encodes a postsynaptic density-localized scaffolding protein that interacts with Shank3 to regulate mGluR activity, as a novel autism-risk gene. Rare, potentially deleterious HOMER1 variants identified uniquely in the autism population affected functionally important protein regions or regulatory sequences and co-segregated closely with autism among children of affected families. We also identified rare ASD-associated coding variants predicted to have damaging effects on components of the Ras/MAPK cascade. Collectively, these findings suggest that altered signaling downstream of mGluRs contributes to the pathogenesis of non-syndromic autism
Multi-messenger observations of a binary neutron star merger
- Author
- Aab A
- Aartsen MG
- Abbott BP
- Abbott R
- Abbott TD
- Abbott TMC
- Abdalla H
- Abe F
- Abeysekara AU
- Abramo LR
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- Abreu P
- Acernese F
- Acero F
- Ackermann M
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- Adhikari RX
- Adya VB
- Affeldt C
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- Albuquerque IFM
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- Paoli A
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- Pollmann A Obertacke
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- Racusin J
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- Reichart DE
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- Reitze DH
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- Relich M
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- Sakellariadou M
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- Zaborov D
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- Zadrozny A
- Zadrozny A
- Zaharijas G
- Zaltzman M
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- Zavrtanik M
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- Zhang WC
- Zhang WZ
- Zhang Y
- Zhang Y
- Zhang Y
- Zhang Y-H
- Zhang YF
- Zhang YJ
- Zhang Z
- Zhang ZL
- Zhao C
- Zhao HS
- Zhao JL
- Zhao W
- Zhao XF
- Zheng SJ
- Zhou H
- Zhou J
- Zhou M
- Zhou Z
- Zhu SJ
- Zhu XJ
- Zhu Y
- Zhu YX
- Zhu Z
- Ziegler A
- Zimmerman AB
- Zimmermann B
- Zimnukhov DS
- Ziolkowski M
- Zoll M
- Zong Z
- Zorn J
- Zornoza JD
- Zou CL
- Zuccarello F
- Zucker ME
- Zuniga J
- Zweizig J
- Zywucka N
- Publication venue
- 'American Astronomical Society'
- Publication date
- 01/01/2017
- Field of study
On 2017 August 17 a binary neutron star coalescence candidate (later designated GW170817) with merger time 12:41:04 UTC was observed through gravitational waves by the Advanced LIGO and Advanced Virgo detectors. The Fermi Gamma-ray Burst Monitor independently detected a gamma-ray burst (GRB 170817A) with a time delay of ~1.7 s with respect to the merger time. From the gravitational-wave signal, the source was initially localized to a sky region of 31 deg2 at a luminosity distance of 40+8-8 Mpc and with component masses consistent with neutron stars. The component masses were later measured to be in the range 0.86 to 2.26 Mo. An extensive observing campaign was launched across the electromagnetic spectrum leading to the discovery of a bright optical transient (SSS17a, now with the IAU identification of AT 2017gfo) in NGC 4993 (at ~40 Mpc) less than 11 hours after the merger by the One- Meter, Two Hemisphere (1M2H) team using the 1 m Swope Telescope. The optical transient was independently detected by multiple teams within an hour. Subsequent observations targeted the object and its environment. Early ultraviolet observations revealed a blue transient that faded within 48 hours. Optical and infrared observations showed a redward evolution over ~10 days. Following early non-detections, X-ray and radio emission were discovered at the transient’s position ~9 and ~16 days, respectively, after the merger. Both the X-ray and radio emission likely arise from a physical process that is distinct from the one that generates the UV/optical/near-infrared emission. No ultra-high-energy gamma-rays and no neutrino candidates consistent with the source were found in follow-up searches. These observations support the hypothesis that GW170817 was produced by the merger of two neutron stars in NGC4993 followed by a short gamma-ray burst (GRB 170817A) and a kilonova/macronova powered by the radioactive decay of r-process nuclei synthesized in the ejecta
Search for gravitational waves from Scorpius X-1 in the second Advanced LIGO observing run with an improved hidden Markov model
- Author
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- Wei Lw
- Weinert M
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- Westhouse Jw
- Wette K
- Whelan Jt
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- Willke B
- Winkler W
- Wipf Cc
- Wittel H
- Woan G
- Woehler J
- Wofford Jk
- Wright Jl
- Wu Ds
- Wysocki Dm
- Xiao S
- Xu R
- Yamamoto H
- Yancey Cc
- Yang L
- Yang Y
- Yang Z
- Yap Mj
- Yazback M
- Yeeles Dw
- Yu H
- Yu Hc
- Yuen Shr
- Zadrozny A
- Zadrozny Ak
- Zanolin M
- Zelenova T
- Zendri Jp
- Zevin M
- Zhang J
- Zhang L
- Zhang T
- Zhao C
- Zhao G
- Zhou M
- Zhou Z
- Zhu Xj
- Zimmerman Ab
- Zucker Me
- Zweizig J
- Publication venue
- College Park, MD : American Physical Society
- Publication date
- 01/01/2019
- Field of study
We present results from a semicoherent search for continuous gravitational waves from the low-mass x-ray binary Scorpius X-1, using a hidden Markov model (HMM) to track spin wandering. This search improves on previous HMM-based searches of LIGO data by using an improved frequency domain matched filter, the J-statistic, and by analyzing data from Advanced LIGO's second observing run. In the frequency range searched, from 60 to 650 Hz, we find no evidence of gravitational radiation. At 194.6 Hz, the most sensitive search frequency, we report an upper limit on gravitational wave strain (at 95% confidence) of h095%=3.47×10-25 when marginalizing over source inclination angle. This is the most sensitive search for Scorpius X-1, to date, that is specifically designed to be robust in the presence of spin wandering. © 2019 American Physical Society
Search for gravitational waves from Scorpius X-1 in the second Advanced LIGO observing run with an improved hidden Markov model
- Author
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- Willke B
- Winkler W
- Wipf Cc
- Wittel H
- Woan G
- Woehler J
- Wofford Jk
- Wright Jl
- Wu Ds
- Wysocki Dm
- Xiao S
- Xu R
- Yamamoto H
- Yancey Cc
- Yang L
- Yang Y
- Yang Z
- Yap Mj
- Yazback M
- Yeeles Dw
- Yu H
- Yu Hc
- Yuen Shr
- Zadrozny A
- Zadrozny Ak
- Zanolin M
- Zelenova T
- Zendri Jp
- Zevin M
- Zhang J
- Zhang L
- Zhang T
- Zhao C
- Zhao G
- Zhou M
- Zhou Z
- Zhu Xj
- Zimmerman Ab
- Zucker Me
- Zweizig J
- Publication venue
- 'American Physical Society (APS)'
- Publication date
- 01/01/2019
- Field of study
We present results from a semicoherent search for continuous gravitational waves from the low-mass x-ray binary Scorpius X-1, using a hidden Markov model (HMM) to track spin wandering. This search improves on previous HMM-based searches of LIGO data by using an improved frequency domain matched filter, the J-statistic, and by analyzing data from Advanced LIGO’s second observing run. In the frequency range searched, from 60 to 650 Hz, we find no evidence of gravitational radiation. At 194.6 Hz, the most sensitive search frequency, we report an upper limit on gravitational wave strain (at 95% confidence) of h95%0=3.47×10−25 when marginalizing over source inclination angle. This is the most sensitive search for Scorpius X-1, to date, that is specifically designed to be robust in the presence of spin wandering
Gravitational Waves and Gamma-Rays from a Binary Neutron Star Merger: GW170817 and GRB 170817A
- Author
- Abbott BP
- Abbott R
- Abbott TD
- Acernese F
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- Wright JL
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- Wysocki DM
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- Yamamoto H
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- Yang L
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- Yazback M
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- Yu H
- Yvert M
- Zadrozny A
- Zanolin M
- Zelenova T
- Zendri J-P
- Zertuche LM
- Zevin M
- Zhang L
- Zhang M
- Zhang T
- Zhang Y-H
- Zhao C
- Zhou M
- Zhou Z
- Zhu SJ
- Zhu XJ
- Zimmerman AB
- Zucker ME
- Zweizig J
- Publication venue
- 'American Astronomical Society'
- Publication date
- 01/01/2017
- Field of study
On 2017 August 17, the gravitational-wave event GW170817 was observed by the Advanced LIGO and Virgo detectors, and the gamma-ray burst (GRB) GRB 170817A was observed independently by the Fermi Gamma-ray Burst Monitor, and the Anti-Coincidence Shield for the Spectrometer for the International Gamma-Ray Astrophysics Laboratory. The probability of the near-simultaneous temporal and spatial observation of GRB 170817A and GW170817 occurring by chance is 5.0×10−8. We therefore confirm binary neutron star mergers as a progenitor of short GRBs. The association of GW170817 and GRB 170817A provides new insight into fundamental physics and the origin of short GRBs. We use the observed time delay of (+1.74±0.05)s between GRB 170817A and GW170817 to: (i) constrain the difference between the speed of gravity and the speed of light to be between −3×10−15 and +7×10−16 times the speed of light, (ii) place new bounds on the violation of Lorentz invariance, (iii) present a new test of the equivalence principle by constraining the Shapiro delay between gravitational and electromagnetic radiation. We also use the time delay to constrain the size and bulk Lorentz factor of the region emitting the gamma-rays. GRB 170817A is the closest short GRB with a known distance, but is between 2 and 6 orders of magnitude less energetic than other bursts with measured redshift. A new generation of gamma-ray detectors, and subthreshold searches in existing detectors, will be essential to detect similar short bursts at greater distances. Finally, we predict a joint detection rate for the Fermi Gamma-ray Burst Monitor and the Advanced LIGO and Virgo detectors of 0.1-1.4 per year during the 2018-2019 observing run and 0.3-1.7 per year at design sensitivity
GWTC-2.1: Deep extended catalog of compact binary coalescences observed by LIGO and Virgo during the first half of the third observing run
- Author
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- Zucker ME
- Zweizig J
- Publication venue
- 'American Physical Society (APS)'
- Publication date
- 15/01/2024
- Field of study
The second Gravitational-Wave Transient Catalog, GWTC-2, reported on 39 compact binary coalescences observed by the Advanced LIGO and Advanced Virgo detectors between 1 April 2019 15 ∶ 00 UTC and 1 October 2019 15 ∶ 00 UTC. Here, we present GWTC-2.1, which reports on a deeper list of candidate events observed over the same period. We analyze the final version of the strain data over this period with improved calibration and better subtraction of excess noise, which has been publicly released. We employ three matched-filter search pipelines for candidate identification, and estimate the probability of astrophysical origin for each candidate event. While GWTC-2 used a false alarm rate threshold of 2 per year, we include in GWTC-2.1, 1201 candidates that pass a false alarm rate threshold of 2 per day. We calculate the source properties of a subset of 44 high-significance candidates that have a probability of astrophysical origin greater than 0.5. Of these candidates, 36 have been reported in GWTC-2. We also calculate updated source properties for all binary black hole events previously reported in GWTC-1. If the eight additional high-significance candidates presented here are astrophysical, the mass range of events that are unambiguously identified as binary black holes (both objects ≥ 3 M⊙ ) is increased compared to GWTC-2, with total masses from ∼ 14 M ⊙ for GW190924_021846 to ∼ 182 M⊙ for GW190426_190642. Source properties calculated using our default prior suggest that the primary components of two new candidate events (GW190403_051519 and GW190426_190642) fall in the mass gap predicted by pair-instability supernova theory. We also expand the population of binaries with significantly asymmetric mass ratios reported in GWTC-2 by an additional two events (the mass ratio is less than 0.65 and 0.44 at 90% probability for GW190403_051519 and GW190917_114630 respectively), and find that two of the eight new events have effective inspiral spins χeff > 0 (at 90% credibility), while no binary is consistent with χeff < 0 at the same significance. We provide updated estimates for rates of binary black hole and binary neutron star coalescence in the local Universe
All-sky search for continuous gravitational waves from isolated neutron stars in the early O3 LIGO data
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- Yamamoto Kazuhiro
- Yamamoto Kohei
- Yamamoto T
- Yamashita K
- Yamazaki R
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- Yang Yang
- Yang Yi
- Yang Z
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- Yelikar AB
- Ying M
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- Zhu Z-H
- Zucker ME
- Zweizig J
- Publication venue
- AMER PHYSICAL SOC
- Publication date
- 15/10/2021
- Field of study
We report on an all-sky search for continuous gravitational waves in the frequency band 20-2000 Hz and with a frequency time derivative in the range of [-1.0,+0.1]×10-8 Hz/s. Such a signal could be produced by a nearby, spinning and slightly nonaxisymmetric isolated neutron star in our Galaxy. This search uses the LIGO data from the first six months of Advanced LIGO's and Advanced Virgo's third observational run, O3. No periodic gravitational wave signals are observed, and 95% confidence-level (C.L.) frequentist upper limits are placed on their strengths. The lowest upper limits on worst-case (linearly polarized) strain amplitude h0 are ∼1.7×10-25 near 200 Hz. For a circularly polarized source (most favorable orientation), the lowest upper limits are ∼6.3×10-26. These strict frequentist upper limits refer to all sky locations and the entire range of frequency derivative values. For a population-averaged ensemble of sky locations and stellar orientations, the lowest 95% C.L. upper limits on the strain amplitude are ∼1.4×10-25. These upper limits improve upon our previously published all-sky results, with the greatest improvement (factor of ∼2) seen at higher frequencies, in part because quantum squeezing has dramatically improved the detector noise level relative to the second observational run, O2. These limits are the most constraining to date over most of the parameter space searched
All-sky, all-frequency directional search for persistent gravitational waves from Advanced LIGO’s and Advanced Virgo’s first three observing runs
- Author
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- Zucker ME
- Zweizig J
- Publication venue
- 'American Physical Society (APS)'
- Publication date
- 03/06/2022
- Field of study
We present the first results from an all-sky all-frequency (ASAF) search for
an anisotropic stochastic gravitational-wave background using the data from the
first three observing runs of the Advanced LIGO and Advanced Virgo detectors.
Upper limit maps on broadband anisotropies of a persistent stochastic
background were published for all observing runs of the LIGO-Virgo detectors.
However, a broadband analysis is likely to miss narrowband signals as the
signal-to-noise ratio of a narrowband signal can be significantly reduced when
combined with detector output from other frequencies. Data folding and the
computationally efficient analysis pipeline, {\tt PyStoch}, enable us to
perform the radiometer map-making at every frequency bin. We perform the search
at 3072 {\tt{HEALPix}} equal area pixels uniformly tiling the sky and in every
frequency bin of width 1/32~Hz in the range 20−1726~Hz, except for bins
that are likely to contain instrumental artefacts and hence are notched. We do
not find any statistically significant evidence for the existence of narrowband
gravitational-wave signals in the analyzed frequency bins. Therefore, we place
95% confidence upper limits on the gravitational-wave strain for each
pixel-frequency pair, the limits are in the range (0.030−9.6)×10−24. In addition, we outline a method to identify candidate
pixel-frequency pairs that could be followed up by a more sensitive (and
potentially computationally expensive) search, e.g., a matched-filtering-based
analysis, to look for fainter nearly monochromatic coherent signals. The ASAF
analysis is inherently independent of models describing any spectral or spatial
distribution of power. We demonstrate that the ASAF results can be
appropriately combined over frequencies and sky directions to successfully
recover the broadband directional and isotropic results
Multifunctional mitoxantrone-conjugated magnetic nanosystem for targeted therapy of folate receptor-overexpressing malignant cells
- Author
- A Ashokan
- A Aviles
- A Carnero
- A Ferrer
- AA Saei
- Abolfazl Barzegari
- AJ Hollins
- AM Dias
- AY Khosroushahi
- B Mishra
- B Verhoven
- C Alexiou
- C Coester
- C Fang
- C Muller
- C Sun
- C Wilhelm
- D Morgensztern
- Davoud Asgari
- E Afrimzon
- E Allard-Vannier
- EI Matthaiou
- F Madeo
- G Koopman
- George Cokous
- H Chen
- H He
- H Wiig
- HA Jeng
- HL Karlsson
- J Barar
- J Barar
- J Clifford
- J Ezzati Nazhad Dolatabadi
- J Mazerski
- JA Neidhart
- Jaleh Barar
- JW George
- K Bhalla
- K Cain
- KG Wolter
- KR Kalli
- KS Ravichandran
- KY Win
- L Peng
- L Serpe
- M Heidari Majd
- M Heidari Majd
- M Heidari Majd
- M Kamat
- M Moogooee
- M Mooguee
- M Seifrtova
- MD Crespi
- ME Fox
- MF Pinard
- Mohammad Johari-Ahar
- Mostafa Heidari Majd
- MP Melancon
- MW Pfaffl
- MZ Zhang
- O Mashinchian
- O Veiseh
- P Waring
- Q Liu
- RA Petros
- RE Serda
- S Gottschalk
- S Setua
- Sajjad Khani
- SD Perrault
- SH Wu
- SJ Gardai
- SM Hussain
- TP Thomas
- V Harmer
- V Kafil
- Vala Kafil
- W Xing
- WL Langston Suen
- Y Omidi
- Y Omidi
- Y Omidi
- Y Omidi
- Y Omidi
- Y Omidi
- Y Omidi
- Y Zhang
- Yadollah Omidi
- Z He
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
First Measurement of the Hubble Constant from a Dark Standard Siren using the Dark Energy Survey Galaxies and the LIGO/Virgo Binary-Black-hole Merger GW170814
- Author
- Abbott BP
- Abbott R
- Abbott TD
- Abbott TMC
- Abdalla FB
- Abraham S
- Acernese F
- Ackley K
- Adams C
- Adhikari RX
- Adya VB
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- Anderson SB
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- Hamilton EZ
- Hammond G
- Haney M
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- Willke B
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- Winkler W
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- Woehler J
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- Worden J
- Wright JL
- Wu DS
- Wysocki DM
- Xiao L
- Yamamoto H
- Yancey CC
- Yang L
- Yap MJ
- Yazback M
- Yeeles DW
- Yu H
- Yu H
- Yuen SHR
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- Zadrozny AK
- Zanolin M
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- Zendri J-P
- Zertuche LM
- Zevin M
- Zhang J
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- Zhou M
- Zhou Z
- Zhu XJ
- Zimmerman A
- Zucker ME
- Zuntz J
- Zweizig J
- Publication venue
- IOP PUBLISHING LTD
- Publication date
- 01/05/2019
- Field of study
We present a multi-messenger measurement of the Hubble constant H 0 using the binary–black-hole merger GW170814 as a standard siren, combined with a photometric redshift catalog from the Dark Energy Survey (DES). The luminosity distance is obtained from the gravitational wave signal detected by the Laser Interferometer Gravitational-Wave Observatory (LIGO)/Virgo Collaboration (LVC) on 2017 August 14, and the redshift information is provided by the DES Year 3 data. Black hole mergers such as GW170814 are expected to lack bright electromagnetic emission to uniquely identify their host galaxies and build an object-by-object Hubble diagram. However, they are suitable for a statistical measurement, provided that a galaxy catalog of adequate depth and redshift completion is available. Here we present the first Hubble parameter measurement using a black hole merger. Our analysis results in H0=75−32+40kms−1Mpc−1, which is consistent with both SN Ia and cosmic microwave background measurements of the Hubble constant. The quoted 68% credible region comprises 60% of the uniform prior range [20, 140] km s−1 Mpc−1, and it depends on the assumed prior range. If we take a broader prior of [10, 220] km s−1 Mpc−1, we find {H}_{0 {78}_{-24}^{+96}\,\mathrm{km}\,{{\rm{s}}}^{-1}\,{\mathrm{Mpc}}^{-1} (57% of the prior range). Although a weak constraint on the Hubble constant from a single event is expected using the dark siren method, a multifold increase in the LVC event rate is anticipated in the coming years and combinations of many sirens will lead to improved constraints on H 0
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