Drawing Lessons from the U.K. Constitutional Reform Act of 2005

In this City Square dialogue, Professor Judith Maute provided the initial spark in her important 2007 article on reforms to judicial selection in the United Kingdom.[1] In her article, Professor Maute outlined the breathtaking and daring changes implemented in the U.K. that upended centuries of tradition to modernize and strengthen public confidence in the judiciary. Most significant among these changes were the creation of a Supreme Court and dramatically moving the process of becoming a judge away from a secretive appointment to a professional Judicial Appointments Commission.[2] The reforms eschew direct affirmative action, but place an explicit value on diversity among judges.[3] At the time, Professor Maute spoke admiringly of the reforms and suggested some of them might work well in the United States: “To restore public confidence in the courts, people must believe that judges exercise legitimate authority, undistorted by personal or partisan preferences. . . . We could learn much from Britain’s modernized appointive system that aims to be open, transparent, accountable, and more diverse.”[4

Preface: The Legal and Ethical Environment of Business

In writing The Legal and Ethical Environment of Business, Terence Lau and Lisa Johnson had simple aims: To present the often overwhelming legal environment of business in an exciting and relevant way To provide faculty a way of achieving that goal WHAT\u27S NEW IN 2.0: RELEVANT CASES & EXAMPLES With updated information in each chapter, this textbook will continue to illustrate the relevance of law and ethics to the happenings of the present day. NEW AREAS OF COVERAGE: Agency law, ethics, bankruptcy, consumer protection, debtor-creditor relations, and secured transactions. Some of this material may be contained in one or two new chapters, and some of this material may be added as a new section or sections in an existing chapter. This record contains the book\u27s prefac

Introduction: The Legal and Ethical Environment of Business

In writing The Legal and Ethical Environment of Business, the authors have condensed and streamlined the presentation of the key business law topics to ensure that every page is relevant, engaging, and interesting to today’s learners. This highly accessible textbook uses summaries of cases and case excerpts to improve student understanding. Lau and Johnson are focused on getting students to understand the reason for the law rather than just memorizing the law and its key elements. New in This Version: Up-to-date materials relevant to the study of the legal environment. New section on agency added to the chapter on employment law. Added notable events, such as the VW emissions scandal. Video content that help illustrate key points have been added to virtually every section of the text

Naked1 Antagonizes Wnt Signaling by Preventing Nuclear Accumulation of β-Catenin

Cyto-nuclear shuttling of β-catenin is at the epicenter of the canonical Wnt pathway and mutations in genes that result in excessive nuclear accumulation of β-catenin are the driving force behind the initiation of many cancers. Recently, Naked Cuticle homolog 1 (Nkd1) has been identified as a Wnt-induced intracellular negative regulator of canonical Wnt signaling. The current model suggests that Nkd1 acts between Disheveled (Dvl) and β-catenin. Here, we employ the zebrafish embryo to characterize the cellular and biochemical role of Nkd1 in vivo. We demonstrate that Nkd1 binds to β-catenin and prevents its nuclear accumulation. We also show that this interaction is conserved in mammalian cultured cells. Further, we demonstrate that Nkd1 function is dependent on its interaction with the cell membrane. Given the conserved nature of Nkd1, our results shed light on the negative feedback regulation of Wnt signaling through the Nkd1-mediated negative control of nuclear accumulation of β-catenin

Linking behaviour and climate change in intertidal ectotherms: insights from littorinid snails

A key element missing from many predictive models of the impacts of climate change on intertidal ectotherms is the role of individual behaviour. In this synthesis, using littorinid snails as a case study, we show how thermoregulatory behaviours may buffer changes in environmental temperatures. These behaviours include either a flight response, to escape the most extreme conditions and utilize warmer or cooler environments; or a fight response, where individuals modify their own environments to minimize thermal extremes. A conceptual model, generated from studies of littorinid snails, shows that various flight and fight thermoregulatory behaviours may allow an individual to widen its thermal safety margin (TSM) under warming or cooling environmental conditions and hence increase species’ resilience to climate change. Thermoregulatory behaviours may also buffer sublethal fitness impacts associated with thermal stresses. Through this synthesis, we emphasise that future studies need to consider not only animals' physiological limits but also their capacities to buffer the impact of climate change through behavioural responses. Current generalizations, made largely on physiological limits of species, often neglect the buffering effects of behaviour and may, therefore, provide an over-estimation of vulnerability, and consequently poor prediction of the potential impacts of climate change on intertidal ectotherms

Large expert-curated database for benchmarking document similarity detection in biomedical literature search

Document recommendation systems for locating relevant literature have mostly relied on methods developed a decade ago. This is largely due to the lack of a large offline gold-standard benchmark of relevant documents that cover a variety of research fields such that newly developed literature search techniques can be compared, improved and translated into practice. To overcome this bottleneck, we have established the RElevant LIterature SearcH consortium consisting of more than 1500 scientists from 84 countries, who have collectively annotated the relevance of over 180 000 PubMed-listed articles with regard to their respective seed (input) article/s. The majority of annotations were contributed by highly experienced, original authors of the seed articles. The collected data cover 76% of all unique PubMed Medical Subject Headings descriptors. No systematic biases were observed across different experience levels, research fields or time spent on annotations. More importantly, annotations of the same document pairs contributed by different scientists were highly concordant. We further show that the three representative baseline methods used to generate recommended articles for evaluation (Okapi Best Matching 25, Term Frequency-Inverse Document Frequency and PubMed Related Articles) had similar overall performances. Additionally, we found that these methods each tend to produce distinct collections of recommended articles, suggesting that a hybrid method may be required to completely capture all relevant articles. The established database server located at https://relishdb.ict.griffith.edu.au is freely available for the downloading of annotation data and the blind testing of new methods. We expect that this benchmark will be useful for stimulating the development of new powerful techniques for title and title/abstract-based search engines for relevant articles in biomedical research.Peer reviewe