CLEO Spectroscopy Results

Recent contributions of the CLEO experiment to hadron spectroscopy are presented.Comment: 6 pages, 4 figures, presented at Beauty 2005, Assisi, Italy, 20--24 June 2005 References further update

A combined approach of MALDI-TOF mass spectrometry and multivariate analysis as a potential tool for the detection of SARS-CoV-2 virus in nasopharyngeal swabs

Coronavirus disease 2019, known as COVID-19, is caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The early, sensitive and specific detection of SARS-CoV-2 virus is widely recognized as the critical point in responding to the ongoing outbreak. Currently, the diagnosis is based on molecular real time RT-PCR techniques, although their implementation is being threatened due to the extraordinary demand for supplies worldwide. That is why the development of alternative and / or complementary tests becomes so relevant. Here, we exploit the potential of mass spectrometry technology combined with machine learning algorithms, for the detection of COVID-19 positive and negative protein profiles directly from nasopharyngeal swabs samples. According to the preliminary results obtained, accuracy =67.66 %, sensitivity =61.76 %, specificity =71.72 %, and although these parameters still need to be improved to be used as a screening technique, mass spectrometry- based methods coupled with multivariate analysis showed that it is an interesting tool that deserves to be explored as a complementary diagnostic approach due to the low cost and fast performance. However, further steps, such as the analysis of a large number of samples, should be taken in consideration to determine the applicability of the method developed.Fil: Rocca, María Florencia. Dirección Nacional de Instituto de Investigación. Administración Nacional de Laboratorio e Instituto de Salud "Dr. C. G. Malbrán"; Argentina. Universidad Nacional de Santiago del Estero. Facultad de Humanidades Ciencias Sociales y de la Salud. Instituto de Estudios e Investigaciones en Enfermería; Argentina. Red Nacional de Espectrometría de Masas Aplicada a la Microbiología Clínica; ArgentinaFil: Zintgraff, Jonathan Cristian. Dirección Nacional de Instituto de Investigación. Administración Nacional de Laboratorio e Instituto de Salud "Dr. C. G. Malbrán"; Argentina. Universidad Nacional de Santiago del Estero. Facultad de Humanidades Ciencias Sociales y de la Salud. Instituto de Estudios e Investigaciones en Enfermería; Argentina. Red Nacional de Espectrometría de Masas Aplicada a la Microbiología Clínica; ArgentinaFil: Dattero, María Elena. Universidad Nacional de Santiago del Estero. Facultad de Humanidades Ciencias Sociales y de la Salud. Instituto de Estudios e Investigaciones en Enfermería; Argentina. Administración Nacional de Laboratorios e Institutos de Salud "Dr. Carlos G. Malbrán". Instituto Nacional de Medicina Tropical; ArgentinaFil: Santos, Leonardo Silva. Universidad de Talca; ChileFil: Ledesma, Martin Manuel. Red Nacional de Espectrometría de Masas Aplicada A la Microbiología Clínica (renaem Argentina); Argentina. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Vay, Carlos Alberto. Red Nacional de Espectrometría de Masas Aplicada a la Microbiología Clínica; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; ArgentinaFil: Prieto, Mónica Raquel. Red Nacional de Espectrometría de Masas Aplicada a la Microbiología Clínica; Argentina. Universidad de Buenos Aires; ArgentinaFil: Benedetti, Estefanía. Universidad Nacional de Santiago del Estero. Facultad de Humanidades Ciencias Sociales y de la Salud. Instituto de Estudios e Investigaciones en Enfermería; Argentina. Administración Nacional de Laboratorios e Institutos de Salud "Dr. Carlos G. Malbrán". Instituto Nacional de Medicina Tropical; ArgentinaFil: Avaro, Martín. Universidad Nacional de Santiago del Estero. Facultad de Humanidades Ciencias Sociales y de la Salud. Instituto de Estudios e Investigaciones en Enfermería; Argentina. Administración Nacional de Laboratorios e Institutos de Salud "Dr. Carlos G. Malbrán". Instituto Nacional de Medicina Tropical; ArgentinaFil: Russo, Mara Laura. Universidad Nacional de Santiago del Estero. Facultad de Humanidades Ciencias Sociales y de la Salud. Instituto de Estudios e Investigaciones en Enfermería; Argentina. Administración Nacional de Laboratorios e Institutos de Salud "Dr. Carlos G. Malbrán". Instituto Nacional de Medicina Tropical; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Nachtigall, Fabiane Manke. Universidad Autónoma de Chile; ChileFil: Baumeister, Elsa. Universidad Nacional de Santiago del Estero. Facultad de Humanidades Ciencias Sociales y de la Salud. Instituto de Estudios e Investigaciones en Enfermería; Argentina. Administración Nacional de Laboratorios e Institutos de Salud "Dr. Carlos G. Malbrán". Instituto Nacional de Medicina Tropical; Argentin

Introduction:Structuralists of the world unite

Supplementary Table S3: Temporally significant metabolites from DMSO treatment as determined by t-test, p<0.05. These tables include all metabolites that were significantly changing from DMSO control treatment between A) 0.5 – 1 h (72 metabolites), B) 0.5 – 4 h (76 metabolites), and C) 1 - 4 h (25 metabolites). Metabolites were included in this table if annotated with either KEGGID or HMDBID. Tables include compound name, KEGGID (if applicable), HMDBID (if applicable), and p-value from t-test (methods described above)

Production of singlet P-wave ccˉc \bar c and bbˉb \bar b states

No spin-singlet $b \bar b$ quarkonium state has yet been observed. In this paper we discuss the production of the singlet P-wave $b\bar{b}$ and $c\bar{c}$ $^1P_1$ states $h_b$ and $h_c$. We consider two possibilities. In the first the $^1P_1$ states are produced via the electromagnetic cascades \ups(3S) \to \eta_b(2S) + \gamma \to h_b + \gamma \gamma \to \eta_b +\gamma\gamma\gamma and $\psi'\to \eta_c' + \gamma \to h_c + \gamma \gamma \to \eta_c + \gamma\gamma\gamma$. A more promising process consists of single pion transition to the $^1P_1$ state followed by the radiative transition to the $1^1S_0$ state: \ups(3S)\to h_b + \pi^0 \to \eta_b + \pi^0 +\gamma and $\psi' \to h_c + \pi^0 \to \eta_c + \pi^0 +\gamma$. For a million \ups(3S) or $\psi'$'s produced we expect these processes to produce several hundred events.Comment: 13 pages, LaTeX, 1 figure, to be published Phys. Rev. D. Some equation numbers and one table number correcte

Combinatorial Binding in Human and Mouse Embryonic Stem Cells Identifies Conserved Enhancers Active in Early Embryonic Development

Transcription factors are proteins that regulate gene expression by binding to cis-regulatory sequences such as promoters and enhancers. In embryonic stem (ES) cells, binding of the transcription factors OCT4, SOX2 and NANOG is essential to maintain the capacity of the cells to differentiate into any cell type of the developing embryo. It is known that transcription factors interact to regulate gene expression. In this study we show that combinatorial binding is strongly associated with co-localization of the transcriptional co-activator Mediator, H3K27ac and increased expression of nearby genes in embryonic stem cells. We observe that the same loci bound by Oct4, Nanog and Sox2 in ES cells frequently drive expression in early embryonic development. Comparison of mouse and human ES cells shows that less than 5% of individual binding events for OCT4, SOX2 and NANOG are shared between species. In contrast, about 15% of combinatorial binding events and even between 53% and 63% of combinatorial binding events at enhancers active in early development are conserved. Our analysis suggests that the combination of OCT4, SOX2 and NANOG binding is critical for transcription in ES cells and likely plays an important role for embryogenesis by binding at conserved early developmental enhancers. Our data suggests that the fast evolutionary rewiring of regulatory networks mainly affects individual binding events, whereas “gene regulatory hotspots” which are bound by multiple factors and active in multiple tissues throughout early development are under stronger evolutionary constraints

Large expert-curated database for benchmarking document similarity detection in biomedical literature search

Document recommendation systems for locating relevant literature have mostly relied on methods developed a decade ago. This is largely due to the lack of a large offline gold-standard benchmark of relevant documents that cover a variety of research fields such that newly developed literature search techniques can be compared, improved and translated into practice. To overcome this bottleneck, we have established the RElevant LIterature SearcH consortium consisting of more than 1500 scientists from 84 countries, who have collectively annotated the relevance of over 180 000 PubMed-listed articles with regard to their respective seed (input) article/s. The majority of annotations were contributed by highly experienced, original authors of the seed articles. The collected data cover 76% of all unique PubMed Medical Subject Headings descriptors. No systematic biases were observed across different experience levels, research fields or time spent on annotations. More importantly, annotations of the same document pairs contributed by different scientists were highly concordant. We further show that the three representative baseline methods used to generate recommended articles for evaluation (Okapi Best Matching 25, Term Frequency-Inverse Document Frequency and PubMed Related Articles) had similar overall performances. Additionally, we found that these methods each tend to produce distinct collections of recommended articles, suggesting that a hybrid method may be required to completely capture all relevant articles. The established database server located at https://relishdb.ict.griffith.edu.au is freely available for the downloading of annotation data and the blind testing of new methods. We expect that this benchmark will be useful for stimulating the development of new powerful techniques for title and title/abstract-based search engines for relevant articles in biomedical research.Peer reviewe

Small-scale testing of rehabilitated pile groups

Paper presented at the International Conference on Re-use of Foundations for Urban Sites (RuFUS), 19-20 October, 2006, Watford, U.K.The grouted, helical pier system (GHPS) is proposed as an example of a capacity improvement option for existing pile foundation groups. This paper explores the relative relationships between these geotechnical elements through the implementation of small-scale ground modification techniques causing increases in the axial capacity of the foundation, as measured as a function of load-based deflection. This initial set of tests indicates clear improvement of both piled and non-piled foundations through a variety of intervention methods both in terms of overall capacity and with respect to generating that capacity with smaller mobilization levels. The testing program also showed the likelihood for using some form of superposition as viable design methodology for predicting the performance of existing cast-in-place foundations that have been upgraded with ground-reinforcement and ground-improvement techniques.Other funderNational Science Foundation (NSF)Conference website n/a but invite at http://www.bre.co.uk/pdf/events/RuFUS_invite.pdf. DG 02/07/10 au,ti,ke,ab.kpw27/9/1

Building reuse assessment for sustainable urban reconstruction

Building reuse is a linchpin to managing solid waste. Despite the various benefits beyond contributing to sustainability that can be realized through building reuse, including direct and indirect cost savings, truncated construction schedules, and reduced site disruptions, little formal consideration has been given to this topic, which places professional engineers at a disadvantage, when considering this as a design option. As each building project has its own specific requirements, reuse is not always the most economical solution, however, in cases where reuse is in part motivated by other factors such as heritage protection, substantial economic and environmental savings can be realized in tandem. Based on nearly two decades of professional experience, a generalized assessment method for reuse is proposed to facilitate benefit maximization. Applying this 10 step method, the costs related to building replacement and sustainable reuse are compared using two case histories and a theoretical building resulting. A clear correlation is shown as to the potential for savings as a function of project size.Not applicableNeed to link to publisher version at: http://cedb.asce.org/cgi/WWWdisplay.cgi?163065 au,ti,ke -AL 21/07/201

Small-scale testing of rehabilitated pile groups

Paper presented at the International Conference on Re-use of Foundations for Urban Sites (RuFUS), 19-20 October, 2006, Watford, U.K.The grouted, helical pier system (GHPS) is proposed as an example of a capacity improvement option for existing pile foundation groups. This paper explores the relative relationships between these geotechnical elements through the implementation of small-scale ground modification techniques causing increases in the axial capacity of the foundation, as measured as a function of load-based deflection. This initial set of tests indicates clear improvement of both piled and non-piled foundations through a variety of intervention methods both in terms of overall capacity and with respect to generating that capacity with smaller mobilization levels. The testing program also showed the likelihood for using some form of superposition as viable design methodology for predicting the performance of existing cast-in-place foundations that have been upgraded with ground-reinforcement and ground-improvement techniques.Other funderNational Science Foundation (NSF)Conference website n/a but invite at http://www.bre.co.uk/pdf/events/RuFUS_invite.pdf. DG 02/07/10 au,ti,ke,ab.kpw27/9/1

Building reuse assessment for sustainable urban reconstruction

Building reuse is a linchpin to managing solid waste. Despite the various benefits beyond contributing to sustainability that can be realized through building reuse, including direct and indirect cost savings, truncated construction schedules, and reduced site disruptions, little formal consideration has been given to this topic, which places professional engineers at a disadvantage, when considering this as a design option. As each building project has its own specific requirements, reuse is not always the most economical solution, however, in cases where reuse is in part motivated by other factors such as heritage protection, substantial economic and environmental savings can be realized in tandem. Based on nearly two decades of professional experience, a generalized assessment method for reuse is proposed to facilitate benefit maximization. Applying this 10 step method, the costs related to building replacement and sustainable reuse are compared using two case histories and a theoretical building resulting. A clear correlation is shown as to the potential for savings as a function of project size.Not applicableNeed to link to publisher version at: http://cedb.asce.org/cgi/WWWdisplay.cgi?163065 au,ti,ke -AL 21/07/201