Issues in evaluating tax and payment arrangements for publicly owned minerals

Many developing countries are still heavily dependent on mineral extraction to generate fiscal revenue and to earn foreign exchange. When minerals form a significant proportion of the country's asset base it is particularly important to have a framework to evaluate the adequacy of compensation schemes. Are these countries collecting enough in return for depleting their reserves? Are these countries carrying too much of the risk? This paper describes work in progress in developing such a framework. In many mineral dependent countries, the government holds the mineral rights and enters into compensation agreements with public or private firms that will extract the resources. Given the high degree of risk and uncertainty associated with mineral development, determining tax/payment arrangements is further complicated by the need to develop risk-sharing schemes between government and the resource extractors. This paper reviews these issues briefly and concludes that when objectives are not perfectly correlated it is preferable to use multiple instruments and to match each instrument to an objectives.Economic Theory&Research,Environmental Economics&Policies,Health Economics&Finance,Banks&Banking Reform,Insurance&Risk Mitigation

Dynamics of Lamin-A Processing Following Precursor Accumulation

Lamin A (LaA) is a component of the nuclear lamina, an intermediate filament meshwork that underlies the inner nuclear membrane (INM) of the nuclear envelope (NE). Newly synthesized prelamin A (PreA) undergoes extensive processing involving C-terminal farnesylation followed by proteolysis yielding non-farnesylated mature lamin A. Different inhibitors of these processing events are currently used therapeutically. Hutchinson-Gilford Progeria Syndrome (HGPS) is most commonly caused by mutations leading to an accumulation of a farnesylated LaA isoform, prompting a clinical trial using farnesyltransferase inhibitors (FTI) to reduce this modification. At therapeutic levels, HIV protease inhibitors (PI) can unexpectedly inhibit the final processing step in PreA maturation. We have examined the dynamics of LaA processing and associated cellular effects during PI or FTI treatment and following inhibitor washout. While PI reversibility was rapid, with respect to both LaA maturation and associated cellular phenotype, recovery from FTI treatment was more gradual. FTI reversibility is influenced by both cell type and rate of proliferation. These results suggest a less static lamin network than has previously been observed

Enabling success at university: the impact of an Australian programme to provide access to university

In Australia access to university studies is supported through students’ participation in government funded, pre-award programmes called ‘enabling’ programmes. These programmes allow students to meet university entry requirements and are designed to prepare students for the rigours of study. This article explores the performance and experience of students studying a range of undergraduate degrees after completing an enabling programme in a regional Australian university. Institutional data confirmed that post-enabling students in this study performed better in undergraduate programmes than traditionally enrolled students when grade point average (GPA), success and retention rates were compared. Students’ beliefs about the reason for this success were clustered within the six themes of confidence, ways of studying, managing lifeload, skills obtained, their attitudes to study, and the enabling programme staff and teaching. Students openly discussed their challenges and skills gained, and demonstrated confidence and resilience in undergraduate study. Staff reflections highlighted similar themes to those of the students, although in a different sequence of importance. Taken together, these three sets of results confirm that students who completed the enabling programme in this study were likely to succeed both personally and in their programmes of future study

Activating Transcription Factor-2 Affects Skeletal Growth by Modulating pRb Gene Expression

Endochondral ossification is the process of skeletal bone growth via the formation of a cartilage template that subsequently undergoes mineralization to form trabecular bone. Genetic mutations affecting the proliferation or differentiation of chondrocytes result in skeletal abnormalities. Activating transcription factor-2 (ATF-2) modulates expression of cell cycle regulatory genes in chondrocytes, and mutation of ATF-2 results in a dwarfed phenotype. Here we investigate the regulatory role that ATF-2 plays in expression of the pocket proteins, cell cycle regulators important in cellular proliferation and differentiation. The spatial and temporal pattern of pocket protein expression was identified in wild type and mutant growth plates. Expression of retinoblastoma (pRb) mRNA and protein were decreased in ATF-2 mutant primary chondrocytes. pRb mRNA expression was coordinated with chondrogenic differentiation and cell cycle exit in ATDC5 cells. Type X collagen immunohistochemistry was performed to visualize a delay in differentiation in response to loss of ATF-2 signaling. Chondrocyte proliferation was also affected by loss of ATF-2. These studies suggest pRb plays a role in chondrocyte proliferation, differentiation and growth plate development by modulating cell cycle progression. ATF-2 regulates expression of pRb within the developing growth plate, contributing to the skeletal phenotype of ATF-2 mutant mice through the regulation of chondrocyte proliferation and differentiation

Hybrid Neoliberalism: Implications for Sustainable Development

Neoliberalism is frequently blamed for challenges in achieving sustainable development; consequently some also question if sustainability is still a useful concept. Neoliberal influence on natural resource management has evolved over the last 30 years to a hybrid form that seeks to compensate for its negative social and environmental externalities. Through review of literature and critical analysis of three case studies of resource development in Australia and New Zealand, we argue that, in spite of modifications under hybrid approaches, neoliberalism still tests achievement of sustainability goals, due to privileging industry and shifting risk and costs to future generations, through inadequate regulation, neglect of public consultation, lack of transparency, and weak impact assessment. We suggest that while neoliberal approaches bring both benefits and disadvantages, sustainability principles must continue to be kept at the forefront of legislation, regulation and management

Hybrid Neoliberalism: Implications for Sustainable Development

Neoliberalism is frequently blamed for challenges in achieving sustainable development; consequently some also question if sustainability is still a useful concept. Neoliberal influence on natural resource management has evolved over the last 30 years to a hybrid form that seeks to compensate for its negative social and environmental externalities. Through review of literature and critical analysis of three case studies of resource development in Australia and New Zealand, we argue that, in spite of modifications under hybrid approaches, neoliberalism still tests achievement of sustainability goals, due to privileging industry and shifting risk and costs to future generations, through inadequate regulation, neglect of public consultation, lack of transparency, and weak impact assessment. We suggest that while neoliberal approaches bring both benefits and disadvantages, sustainability principles must continue to be kept at the forefront of legislation, regulation and management.Peer Reviewe

Contemporary Epidemiology : A Review of Critical Discussions Within the Discipline and A Call for Further Dialogue with Social Theory

The discipline of epidemiology, which holds major influence on public health policy as well as on clinical medical practice, has in recent decades to a large extent been concerned with the identification of factors and markers of risk for disease. Much health information and intervention is thus informed by a wealth of studies on a variety of risk factors, of which the individual is encouraged to keep informed and to be responsible about. Meanwhile, risk factor epidemiology has been subject to intense debate, both within and outside the discipline. The following review offers an overview of critical intradisciplinary debates. It then opens discussion on three partially overlapping areas where social theory has been called upon to contribute to epidemiological inquiry, namely analysis of macro-social determinants of health and disease, of categories of human difference and of embodiment. The review ends with, and is motivated by, a plea for further integration of and dialogue between epidemiology and social theory