The Clash of Perceptions

This study challenges Samuel Huntington’s well-known clash of civilizations paradigm based on a philosophical reasoning of cognitive proofs. The authors propose the clash of perceptions, an alternative paradigm that better reflects the complexity of individual and collective interactions. Building on case studies and recent cognitive science and informatics research, this paradigm offers greater insight into the dynamics of international relations. In the first section, the authors explain the conceptual and methodological limits of Huntington’s paradigm before proposing in the second section a new approach geared toward individual and group phenomena aiming to model the clash of perceptions. New concepts such as percepts, misperception, misconception and perception prototypes are introduced in order to explain this complex process. These concepts help better understand the complexity of conflict among individuals, groups and nation states

CD4+ Regulatory and Effector/Memory T Cell Subsets Profile Motor Dysfunction in Parkinson’s Disease

Animal models and clinical studies have linked the innate and adaptive immune system to the pathology of Parkinson’s disease (PD). Despite such progress, the specific immune responses that influence disease progression have eluded investigators. Herein, we assessed relationships between T cell phenotype and function with PD progression. Peripheral blood lymphocytes from two separate cohorts, a discovery cohort and a validation cohort, totaling 113 PD patients and 96 age- and environment-matched caregivers were examined by flow cytometric analysis and T cell proliferation assays. Increased effector/memory T cells (Tem), defined as CD45RO+ and FAS+ CD4+ T cells and decreased CD31+ and α4β7+ CD4+ T cells were associated with progressive Unified Parkinson’s Disease Rating Scale III scores. However, no associations were seen between immune biomarkers and increased age or disease duration. Impaired abilities of regulatory T cells (Treg) from PD patients to suppress effector T cell function was observed. These data support the concept that chronic immune stimulation, notably Tem activation and Treg dysfunction is linked to PD pathobiology and disease severity, but not disease duration. The association of T cell phenotypes with motor symptoms provides fresh avenues for novel biomarkers and therapeutic designs

UEV-1 Is an Ubiquitin-Conjugating Enzyme Variant That Regulates Glutamate Receptor Trafficking in C. elegans Neurons

The regulation of AMPA-type glutamate receptor (AMPAR) membrane trafficking is a key mechanism by which neurons regulate synaptic strength and plasticity. AMPAR trafficking is modulated through a combination of receptor phosphorylation, ubiquitination, endocytosis, and recycling, yet the factors that mediate these processes are just beginning to be uncovered. Here we identify the ubiquitin-conjugating enzyme variant UEV-1 as a regulator of AMPAR trafficking in vivo. We identified mutations in uev-1 in a genetic screen for mutants with altered trafficking of the AMPAR subunit GLR-1 in C. elegans interneurons. Loss of uev-1 activity results in the accumulation of GLR-1 in elongated accretions in neuron cell bodies and along the ventral cord neurites. Mutants also have a corresponding behavioral defect—a decrease in spontaneous reversals in locomotion—consistent with diminished GLR-1 function. The localization of other synaptic proteins in uev-1-mutant interneurons appears normal, indicating that the GLR-1 trafficking defects are not due to gross deficiencies in synapse formation or overall protein trafficking. We provide evidence that GLR-1 accumulates at RAB-10-containing endosomes in uev-1 mutants, and that receptors arrive at these endosomes independent of clathrin-mediated endocytosis. UEV-1 homologs in other species bind to the ubiquitin-conjugating enzyme Ubc13 to create K63-linked polyubiquitin chains on substrate proteins. We find that whereas UEV-1 can interact with C. elegans UBC-13, global levels of K63-linked ubiquitination throughout nematodes appear to be unaffected in uev-1 mutants, even though UEV-1 is broadly expressed in most tissues. Nevertheless, ubc-13 mutants are similar in phenotype to uev-1 mutants, suggesting that the two proteins do work together to regulate GLR-1 trafficking. Our results suggest that UEV-1 could regulate a small subset of K63-linked ubiquitination events in nematodes, at least one of which is critical in regulating GLR-1 trafficking

Multi-messenger observations of a binary neutron star merger

On 2017 August 17 a binary neutron star coalescence candidate (later designated GW170817) with merger time 12:41:04 UTC was observed through gravitational waves by the Advanced LIGO and Advanced Virgo detectors. The Fermi Gamma-ray Burst Monitor independently detected a gamma-ray burst (GRB 170817A) with a time delay of ~1.7 s with respect to the merger time. From the gravitational-wave signal, the source was initially localized to a sky region of 31 deg2 at a luminosity distance of 40+8-8 Mpc and with component masses consistent with neutron stars. The component masses were later measured to be in the range 0.86 to 2.26 Mo. An extensive observing campaign was launched across the electromagnetic spectrum leading to the discovery of a bright optical transient (SSS17a, now with the IAU identification of AT 2017gfo) in NGC 4993 (at ~40 Mpc) less than 11 hours after the merger by the One- Meter, Two Hemisphere (1M2H) team using the 1 m Swope Telescope. The optical transient was independently detected by multiple teams within an hour. Subsequent observations targeted the object and its environment. Early ultraviolet observations revealed a blue transient that faded within 48 hours. Optical and infrared observations showed a redward evolution over ~10 days. Following early non-detections, X-ray and radio emission were discovered at the transient’s position ~9 and ~16 days, respectively, after the merger. Both the X-ray and radio emission likely arise from a physical process that is distinct from the one that generates the UV/optical/near-infrared emission. No ultra-high-energy gamma-rays and no neutrino candidates consistent with the source were found in follow-up searches. These observations support the hypothesis that GW170817 was produced by the merger of two neutron stars in NGC4993 followed by a short gamma-ray burst (GRB 170817A) and a kilonova/macronova powered by the radioactive decay of r-process nuclei synthesized in the ejecta

Mortality and pulmonary complications in patients undergoing surgery with perioperative SARS-CoV-2 infection: an international cohort study

Background: The impact of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) on postoperative recovery needs to be understood to inform clinical decision making during and after the COVID-19 pandemic. This study reports 30-day mortality and pulmonary complication rates in patients with perioperative SARS-CoV-2 infection. Methods: This international, multicentre, cohort study at 235 hospitals in 24 countries included all patients undergoing surgery who had SARS-CoV-2 infection confirmed within 7 days before or 30 days after surgery. The primary outcome measure was 30-day postoperative mortality and was assessed in all enrolled patients. The main secondary outcome measure was pulmonary complications, defined as pneumonia, acute respiratory distress syndrome, or unexpected postoperative ventilation. Findings: This analysis includes 1128 patients who had surgery between Jan 1 and March 31, 2020, of whom 835 (74·0%) had emergency surgery and 280 (24·8%) had elective surgery. SARS-CoV-2 infection was confirmed preoperatively in 294 (26·1%) patients. 30-day mortality was 23·8% (268 of 1128). Pulmonary complications occurred in 577 (51·2%) of 1128 patients; 30-day mortality in these patients was 38·0% (219 of 577), accounting for 81·7% (219 of 268) of all deaths. In adjusted analyses, 30-day mortality was associated with male sex (odds ratio 1·75 [95% CI 1·28–2·40], p\textless0·0001), age 70 years or older versus younger than 70 years (2·30 [1·65–3·22], p\textless0·0001), American Society of Anesthesiologists grades 3–5 versus grades 1–2 (2·35 [1·57–3·53], p\textless0·0001), malignant versus benign or obstetric diagnosis (1·55 [1·01–2·39], p=0·046), emergency versus elective surgery (1·67 [1·06–2·63], p=0·026), and major versus minor surgery (1·52 [1·01–2·31], p=0·047). Interpretation: Postoperative pulmonary complications occur in half of patients with perioperative SARS-CoV-2 infection and are associated with high mortality. Thresholds for surgery during the COVID-19 pandemic should be higher than during normal practice, particularly in men aged 70 years and older. Consideration should be given for postponing non-urgent procedures and promoting non-operative treatment to delay or avoid the need for surgery. Funding: National Institute for Health Research (NIHR), Association of Coloproctology of Great Britain and Ireland, Bowel and Cancer Research, Bowel Disease Research Foundation, Association of Upper Gastrointestinal Surgeons, British Association of Surgical Oncology, British Gynaecological Cancer Society, European Society of Coloproctology, NIHR Academy, Sarcoma UK, Vascular Society for Great Britain and Ireland, and Yorkshire Cancer Research

International Consensus Statement on Rhinology and Allergy: Rhinosinusitis

Background: The 5 years since the publication of the first International Consensus Statement on Allergy and Rhinology: Rhinosinusitis (ICAR‐RS) has witnessed foundational progress in our understanding and treatment of rhinologic disease. These advances are reflected within the more than 40 new topics covered within the ICAR‐RS‐2021 as well as updates to the original 140 topics. This executive summary consolidates the evidence‐based findings of the document. Methods: ICAR‐RS presents over 180 topics in the forms of evidence‐based reviews with recommendations (EBRRs), evidence‐based reviews, and literature reviews. The highest grade structured recommendations of the EBRR sections are summarized in this executive summary. Results: ICAR‐RS‐2021 covers 22 topics regarding the medical management of RS, which are grade A/B and are presented in the executive summary. Additionally, 4 topics regarding the surgical management of RS are grade A/B and are presented in the executive summary. Finally, a comprehensive evidence‐based management algorithm is provided. Conclusion: This ICAR‐RS‐2021 executive summary provides a compilation of the evidence‐based recommendations for medical and surgical treatment of the most common forms of RS

Characterizing K2 Candidate Planetary Systems Orbiting Low-mass Stars. II. Planetary Systems Observed during Campaigns 1-7

We recently used near-infrared spectroscopy to improve the characterization of 76 low-mass stars around which K2 had detected 79 candidate transiting planets. 29 of these worlds were new discoveries that had not previously been published. We calculate the false positive probabilities that the transit-like signals are actually caused by non-planetary astrophysical phenomena and reject five new transit-like events and three previously reported events as false positives. We also statistically validate 17 planets (7 of which were previously unpublished), confirm the earlier validation of 22 planets, and announce 17 newly discovered planet candidates. Revising the properties of the associated planet candidates based on the updated host star characteristics and refitting the transit photometry, we find that our sample contains 21 planets or planet candidates with radii smaller than 1.25 R ⊕, 18 super-Earths (1.25-2 R ⊕), 21 small Neptunes (2-4 R ⊕), three large Neptunes (4-6 R ⊕), and eight giant planets (>6 R ⊕). Most of these planets are highly irradiated, but EPIC 206209135.04 (K2-72e, ), EPIC 211988320.01 (), and EPIC 212690867.01 () orbit within optimistic habitable zone boundaries set by the "recent Venus" inner limit and the "early Mars" outer limit. In total, our planet sample includes eight moderately irradiated 1.5-3 R ⊕ planet candidates (F p ≲ 20 F ⊕) orbiting brighter stars (Ks < 11) that are well-suited for atmospheric investigations with the Hubble, Spitzer, and/or James Webb Space Telescopes. Five validated planets orbit relatively bright stars (Kp < 12.5) and are expected to yield radial velocity semi-amplitudes of at least 2 m s-1. Accordingly, they are possible targets for radial velocity mass measurement with current facilities or the upcoming generation of red optical and near-infrared high-precision RV spectrographs

Characterizing K2 Candidate Planetary Systems Orbiting Low-mass Stars. II. Planetary Systems Observed during Campaigns 1-7

We recently used near-infrared spectroscopy to improve the characterization of 76 low-mass stars around which K2 had detected 79 candidate transiting planets. 29 of these worlds were new discoveries that had not previously been published. We calculate the false positive probabilities that the transit-like signals are actually caused by non-planetary astrophysical phenomena and reject five new transit-like events and three previously reported events as false positives. We also statistically validate 17 planets (7 of which were previously unpublished), confirm the earlier validation of 22 planets, and announce 17 newly discovered planet candidates. Revising the properties of the associated planet candidates based on the updated host star characteristics and refitting the transit photometry, we find that our sample contains 21 planets or planet candidates with radii smaller than 1.25 R ⊕, 18 super-Earths (1.25-2 R ⊕), 21 small Neptunes (2-4 R ⊕), three large Neptunes (4-6 R ⊕), and eight giant planets (>6 R ⊕). Most of these planets are highly irradiated, but EPIC 206209135.04 (K2-72e, ), EPIC 211988320.01 (), and EPIC 212690867.01 () orbit within optimistic habitable zone boundaries set by the "recent Venus" inner limit and the "early Mars" outer limit. In total, our planet sample includes eight moderately irradiated 1.5-3 R ⊕ planet candidates (F p ≲ 20 F ⊕) orbiting brighter stars (Ks < 11) that are well-suited for atmospheric investigations with the Hubble, Spitzer, and/or James Webb Space Telescopes. Five validated planets orbit relatively bright stars (Kp < 12.5) and are expected to yield radial velocity semi-amplitudes of at least 2 m s-1. Accordingly, they are possible targets for radial velocity mass measurement with current facilities or the upcoming generation of red optical and near-infrared high-precision RV spectrographs