Historical, Archaeological, and Geophysical Investigations at Two Proposed Safety Rest Areas, Interstate Highway (IH) 10, Chambers County, Texas

Personnel from Coastal Environments, Inc. (CEI), Moore Archeological Consulting, Inc. (MAC), and the University of Mississippi conducted archaeological and geophysical investigations at the locations of two proposed safety rest areas on opposite sides of Interstate Highway (IH) 10 in Chambers County, Texas. The research was carried out from late August 2006 until late February 2007, under contract to the Environmental Affairs Division of the Texas Department of Transportation (TxDOT). MAC archaeologists had previously examined the two rest area tracts in 2001. Their research indicated that the north tract contained a latenineteenth- through early-twentieth-century cemetery, identified as the Broussard Cemetery site (41CH370). Buried within the cemetery are the remains of several members of the locally prominent White family and relatives. The south tract included the remains of a below-ground cistern that likely marked the location of the main house associated with the homestead and ranch of James Taylor White II. It was estimated that this house location, labeled the White Family Cistern site (41CH371), was occupied from ca. 1854 until sometime in the early 1900s. The field investigations examined three specific areas within the two tracts: (1) A small 20-by-45-m area situated about 10 m north of the Broussard Cemetery site where a truck-entrance road is to be built. It was considered possible that unmarked graves located outside the cemetery proper might be present in that area. (2) A 40-by-40-m area within the south tract where MAC personnel had located a piece of whiteware during their earlier investigations. It was thought that a possible outbuilding related to the White homestead might be present in that area. (3) A 110-by-115-m area in the south tract where the main house and most of the White family occupation occurred. The area in the north tract was examined by ground-penetrating radar, resistivity surveys and mechanical stripping of anomalies recognized by the geophysical research. The small square area in the south tract was examined by systematic shovel tests. The large area in the south tract was investigated by systematic shovel tests, a metal detector survey, a geophysical search that included magnetometer and electromagnetic susceptibility surveys, a limited ground-truth assessment of selected anomalies that had been identified by the geophysical surveys, mechanical stripping of other anomalies recognized by the geophysical research, plus the controlled excavation of a few small units in locations where the stripping uncovered potential cultural features. Overall, the various investigations identified the location, orientation, and dimensions of the White family house and its associated kitchen, a rich sheet midden situated to the rear of the house, and several possible outbuildings located to the sides of the structure. Numerous artifacts indicative of the period of suspected occupation were collected, including hundreds of pieces of metal, ceramic fragments, and glass. A few animal bones and plant remains also were obtained. Although the present study did not call for a detailed analysis of these items, such should prove useful in the future. Given these results, it is clear that site 41CH371 is eligible for inclusion in the National Register of Historic Places. Additional archaeological investigations at selected portions of the site are recommended, along with further archival and historical research. Accordingly, construction of the rest area in the south tract should be delayed until the recommended investigations are completed. The small area examined in the north tract near site 41CH370 failed to yield any evidence of burials. Since the cemetery itself will be avoided during construction, no further archaeological work is considered necessary in the north tract. Thus, construction of the rest area within the north tract may proceed as planned

Bayesian hierarchical modeling of longitudinal glaucomatous visual fields using a two-stage approach

The Bayesian approach has become increasingly popular because it allows to fit quite complex models to data via Markov chain Monte Carlo sampling. However, it is also recognized nowadays that Markov chain Monte Carlo sampling can become computationally prohibitive when applied to a large data set. We encountered serious computational difficulties when fitting an hierarchical model to longitudinal glaucoma data of patients who participate in an ongoing Dutch study. To overcome this problem, we applied and extended a recently proposed two-stage approach to model these data. Glaucoma is one of the leading causes of blindness in the world. In order to detect deterioration at an early stage, a model for predicting visual fields (VFs) in time is needed. Hence, the true underlying VF progression can be determined, and treatment strategies can then be optimized to prevent further VF loss. Because we were unable to fit these data with the classical one-stage approach upon which the current popular Bayesian software is based, we made use of the two-stage Bayesian approach. The considered hierarchical longitudinal model involves estimating a large number of random effects and deals with censoring and high measurement variability. In addition, we extended the approach with tools for model evaluation. Copyrigh

Complementarity of Galactic radio and collider data in constraining WIMP dark matter models

In this work we confront dark matter models to constraints that may be derived from radio synchrotron radiation from the Galaxy, taking into account the astrophysical uncertainties and we compare these to bounds set by accelerator and complementary indirect dark matter searches. Specifically we apply our analysis to three popular particle physics models. First, a generic effective operator approach, in which case we set bounds on the corresponding mass scale, and then, two specific UV completions, the Z' and Higgs portals. We show that for many candidates, the radio synchrotron limits are competitive with the other searches, and could even give the strongest constraints (as of today) with some reasonable assumptions regarding the astrophysical uncertainties.Comment: 22 pages, 12 figure

Novel genetic loci associated with hippocampal volume

The hippocampal formation is a brain structure integrally involved in episodic memory, spatial navigation, cognition and stress responsiveness. Structural abnormalities in hippocampal volume and shape are found in several common neuropsychiatric disorders. To identify the genetic underpinnings of hippocampal structure here we perform a genome-wide association study (GWAS) of 33,536 individuals and discover six independent loci significantly associated with hippocampal volume, four of them novel. Of the novel loci, three lie within genes (ASTN2, DPP4 and MAST4) and one is found 200 kb upstream of SHH. A hippocampal subfield analysis shows that a locus within the MSRB3 gene shows evidence of a localized effect along the dentate gyrus, subiculum, CA1 and fissure. Further, we show that genetic variants associated with decreased hippocampal volume are also associated with increased risk for Alzheimer's disease (rg =-0.155). Our findings suggest novel biological pathways through which human genetic variation influences hippocampal volume and risk for neuropsychiatric illness

Large expert-curated database for benchmarking document similarity detection in biomedical literature search

Document recommendation systems for locating relevant literature have mostly relied on methods developed a decade ago. This is largely due to the lack of a large offline gold-standard benchmark of relevant documents that cover a variety of research fields such that newly developed literature search techniques can be compared, improved and translated into practice. To overcome this bottleneck, we have established the RElevant LIterature SearcH consortium consisting of more than 1500 scientists from 84 countries, who have collectively annotated the relevance of over 180 000 PubMed-listed articles with regard to their respective seed (input) article/s. The majority of annotations were contributed by highly experienced, original authors of the seed articles. The collected data cover 76% of all unique PubMed Medical Subject Headings descriptors. No systematic biases were observed across different experience levels, research fields or time spent on annotations. More importantly, annotations of the same document pairs contributed by different scientists were highly concordant. We further show that the three representative baseline methods used to generate recommended articles for evaluation (Okapi Best Matching 25, Term Frequency-Inverse Document Frequency and PubMed Related Articles) had similar overall performances. Additionally, we found that these methods each tend to produce distinct collections of recommended articles, suggesting that a hybrid method may be required to completely capture all relevant articles. The established database server located at https://relishdb.ict.griffith.edu.au is freely available for the downloading of annotation data and the blind testing of new methods. We expect that this benchmark will be useful for stimulating the development of new powerful techniques for title and title/abstract-based search engines for relevant articles in biomedical research.Peer reviewe

On Minimal Dark Matter coupled to the Higgs

International audienceWe provide a unified presentation of extensions of the Minimal Dark Matterframework in which new fermionic electroweak multiplets are coupled to eachother via the Standard Model Higgs doublet. We study systematically the genericfeatures of all the possibilities, starting with a singlet and two doublets(akin to Bino-Higgsino dark matter) up to a Majorana quintuplet coupled to twoWeyl quadruplets. We pay special attention to this last case, since it has notyet been discussed in the literature. We estimate the parameter space forviable dark matter candidates. This includes an estimate for the mass of aquasi-pure quadruplet dark matter candidate taking into account the Sommerfeldeffect. We also argue how the coupling to the Higgs can bring the Minimal DarkMatter scenario within the reach of present and future direct detectionexperiments