Léxico empleado en los anuncios publicitarios nacionales transmitidos durante el programa “La Paloma Mensajera” a través de Tu Nueva Radio Ya en el período de enero a agosto del 2016

El presente trabajo investigativo es un estudio léxico de los anuncios publicitarios nacionales transmitidos durante el programa “La paloma mensajera” en Tu Nueva Radio Ya, durante enero a agosto del 2016. A través del cual se identificaron diferentes vocablos y fraseologismos que se emplean en la grabación de los anuncios. El objetivo principal es el de aportar la caracterización del español de Nicaragua, así como valorar el aporte cultural que tiene el léxico empleado, es por eso que al elaborar este estudio, se toma en cuenta la importancia que tiene este para la cultura de nuestro país. La base teórica es de vital importancia para este estudio, ya que se abordaron aspectos generales de la lingüística, la lengua y sus niveles, habla y dialecto, entre otros y también se incluyeron conceptos de publicidad y radio que son parte de este trabajo La información de este estudio se logró recopilar por medio de la grabación de todos los anuncios publicitarios. El análisis de la información obtenida permitió obtener un corpus de 12 anuncios, de los cuales se lograron sacar 112 palabras. Es por ello que se realizó la contrastividad de la palabras para saber cuáles están en el Diccionario de la lengua española, Diccionario del español de Nicaragua, Diccionario de americanismos y Diccionario de Centroamericanismos, para después elaborar los campos semánticos referente a los vocablos y fraseologismos utilizados en los anuncios publicitarios, y por último la elaboración un glosario, en el cual se obtuvieron 16 nuevos aportes, entre ellos nuevos vocablos y nuevos fraseologismos, que se utilizan a diario y son de vital importancia para el habla nicaragüense

Design of a Robot Prototype with Rocker Geometry-Bogie

In this research a Rocker-Bogie type suspension geometry is designed and validated based on the analysis of the degrees of freedom, for its future implementation within the space exploration industry sector, having as main purpose the collection and transportation of garbage and waste to strategic sectors within the facilities, avoiding obstacles of different levels, although it could also be applied in the industrial, agricultural and mining areas, where a robust and stable system is required. We start by establishing a safety factor, determined through coefficients that involve safety and economy, then we calculate the dimensions and forces to be supported by the structural elements known as Rocker and Bogie, which are responsible for transmitting the support to the chassis as well as providing support to the connections for the axle components and motors for the wheels. The design and calculation of these elements, depends on the robot prototype being able to move through irregular fields avoiding obstacles such as: surface anomalies, potholes, rocks and curbs. For the validation of the prototype design, a static analysis of the structural elements (Rocker and Bogie) is performed by means of the Von Misses parameter, obtaining a high level of safety before rupture. Subsequently, the simulation of the prototype is executed based on a track created in the software, analyzing parameters of speed, acceleration and displacements in the axes X, Y. Finally, the results obtained from the simulation are compared based mainly on height and maximum length between front and rear axles, being crucial the maximum permissible angle of inclination

Design S-N curves for old Portuguese and French riveted bridges connection based on statistical analyses

Maintenance of ancient road and railway metallic bridges has become a major concern for governmental agencies in the past few decades. Indeed, since the construction of these structures, between the end of the 19th century and the beginning of the 20th century, traffic conditions have evolved, both in weight and frequency. In the purpose to assess the remaining life of old metallic bridges, some critical structural details have been identified and associated to S-N curves in order to be used in damage estimation (using Palmgren-Miner’s rule for cumulative damage, for example). These constructional details are described by design rules of several European and North American standards, such as the Eurocode 3, BS 5400 and AASHTO standards. The particularity of ancient bridges is that hot riveted assemblies, commonly used for their construction, are not represented in most construction standards. Further experiences on the matter by numerous research teams have suggested detail category C71 from the Eurocode 3 as appropriate. In this paper, experimental data from double shear assemblies manufactures from three different metallic ancient bridges is used to identify, through a statistical analysis, the S-N curves that best fit this constructional detail. Portuguese and French puddled iron bridges were considered.The authors of this paper thank the National Society of French Railways and the SciTech - Science and Technology for Competitive and Sustainable Industries, R&D project NORTE-01-0145-FEDER-000022 cofinanced by Programa Operacional Regional do Norte ("NORTE2020"), through Fundo Europeu de Desenvolvimento Regional (FEDER) for their collaboration and support during this research works. The authors also acknowledge the Portuguese Science Foundation (FCT) for the financial support through the post-doctoral grant SFRH/BPD/107825/2015

Heridas penetrantes abdominales con lesión vascular

Las lesiones vasculares intra abdominales representan con frecuencia un caso mortífero en un paciente contundido, en este artículo se expuso el escenario de tratamiento de 33 pacientes portadores de traumatismos abdominales penetrantes con lesión vascular, con edad promedio de 24,3 años de edad, intervenidos en los últimos 22 años. Se presentaron un total de 29 heridas vasculares y 35 lesiones asociadas. Los vasos más frecuentemente lesionados fueron: vena cava inferior (21,2%), vasos iliacos (24,2%) y sistema venoso portal (12,1%); con desgarro parcial del 70%. Las lesiones asociadas más frecuentes fueron las de intestino delgado (26%), seguidos por la de hígado (22%). El 72% de los vasos fueron reparados, efectuándose solo 6 ligaduras. La mortalidad de la serie fue del 40% (5 casos) todos ellos con lesiones de extrema complejidad. Se logró el seguimiento del 80% de los casos, los cuales están en buenas condiciones, habiendo desarrollado 2 complicaciones alejadas.Se logró el seguimiento del 80% de los casos, los cuales están en buenas condiciones, habiendo desarrollado 2 complicaciones alejadas.El manejo de estos traumatismos ha de ser agresivo en su monitorización, aportes de volumen e indicación quirúrgica, ya que la sospecha de la lesión vascular y su control, son la mejor arma terapéutica que se dispone

La infección nosocomial. Un reto en las unidades de cuidados intensivos

El estudio de la infección nosocomial en las unidades de cuidados intensivos deviene eje central de la asistencia médica y, un pilar del control de su calidad. Estas unidades asumen un elevado número de pacientes críticamente enfermos con comorbilidad, compromiso inmunológico y en contacto con dispositivos invasivos, factores estos que condicionan la diseminación de bacterias multirresistentes, por lo cual se requiere vigilancia e implementación eficiente de las medidas de prevención y control. En este trabajo se intenta abrir el debate en torno a un reto en las unidades de cuidados intensivos: las infecciones nosocomiales

An Influenza A/H1N1/2009 Hemagglutinin Vaccine Produced in Escherichia coli

The A/H1N1/2009 influenza pandemic made evident the need for faster and higher-yield methods for the production of influenza vaccines. Platforms based on virus culture in mammalian or insect cells are currently under investigation. Alternatively, expression of fragments of the hemagglutinin (HA) protein in prokaryotic systems can potentially be the most efficacious strategy for the manufacture of large quantities of influenza vaccine in a short period of time. Despite experimental evidence on the immunogenic potential of HA protein constructs expressed in bacteria, it is still generally accepted that glycosylation should be a requirement for vaccine efficacy.We expressed the globular HA receptor binding domain, referred to here as HA(63-286)-RBD, of the influenza A/H1N1/2009 virus in Escherichia coli using a simple, robust and scalable process. The recombinant protein was refolded and purified from the insoluble fraction of the cellular lysate as a single species. Recombinant HA(63-286)-RBD appears to be properly folded, as shown by analytical ultracentrifugation and bio-recognition assays. It binds specifically to serum antibodies from influenza A/H1N1/2009 patients and was found to be immunogenic, to be capable of triggering the production of neutralizing antibodies, and to have protective activity in the ferret model.Projections based on our production/purification data indicate that this strategy could yield up to half a billion doses of vaccine per month in a medium-scale pharmaceutical production facility equipped for bacterial culture. Also, our findings demonstrate that glycosylation is not a mandatory requirement for influenza vaccine efficacy

States Of Discontent

Latin America’s recent inclusionary turn centers on changing relationships between the popular sectors and the state. Yet the new inclusion unfolds in a region in which most states are weak and prone to severe pathologies, such as corruption, inefficiency, and particularism. The first part of the chapter outlines an argument, developed at more length elsewhere, regarding how “state crises” helped drive the consolidation of three distinct party system trajectories among the eight South American countries where the Left would eventually win power. The second part of the chapter argues that these trajectories differed in three ways that likely conditioned how the concomitant inclusionary Left turn unfolded in each case: the institutionalization of left-wing parties, the occurrence of state transformation via constitutional reform, and the level of state capacity. The discussion helps highlight the central role of the state and its pathologies in both driving alternative paths of political development and in conditioning the politics of inclusion. By putting the emphasis on the state and its pathologies, we can better consider not just the sources of sociopolitical exclusion but also the limits of sociopolitical inclusion

Sperm DNA fragmentation: A new guideline for clinicians

Sperm DNA integrity is crucial for fertilization and development of healthy offspring. The spermatozoon undergoes extensive molecular remodeling of its nucleus during later phases of spermatogenesis, which imparts compaction and protects the genetic content. Testicular (defective maturation and abortive apoptosis) and post-testicular (oxidative stress) mechanisms are implicated in the etiology of sperm DNA fragmentation (SDF), which affects both natural and assisted reproduction. Several clinical and environmental factors are known to negatively impact sperm DNA integrity. An increasing number of reports emphasizes the direct relationship between sperm DNA damage and male infertility. Currently, several assays are available to assess sperm DNA damage, however, routine assessment of SDF in clinical practice is not recommended by professional organizations

Contribution à la compréhension du comportement mécanique des assemblages rivetés anciens

Numerous metallic bridges can be found in the French railway heritage. Since a majority of these structures was built during the second half of the 19th century, they have been in service for over a hundred years and need an adapted maintenance policy.These doctoral thesis, done in collaboration with SNCF Réseau, improves the understanding of the mechanical behaviour of hot riveted assemblies under monotonic and cyclic loadings. An experimental strategy was proposed and carried out in order to identify the failure mechanisms of riveted assemblies. First, the studied material, a puddled iron, was obtained from recovered elements from the bridge over the Adour river in Bayonne (1864-2013). Mechanical testing and characterisation was performed under monotonic and cyclic loadings. Puddled iron’s brittle, anisotropic and scattered behaviour was observed and analysed. In-house software applications were developed in order to study this kind of material. Additionally, hot riveted specimens (constructional details) were designed, manufactured and tested under monotonic and cyclic loadings. A precise working (and failure) scenario of the double shear mono-rivet assembly was identified. The influence of the material’s behaviour, stress concentrators, shearing of the rivet and clamping force of the rivet were studied. The results obtained during these research works, compared to the ones found in academic literature as well as construction norms for metallic structures, showed the importance and complementarity of a multi-scale approach (material behaviour and local study of assemblies) in order to understand and assess the behaviour of ancient riveted structures.Le patrimoine ferroviaire français comporte de nombreux ponts métalliques, principalement construits au cours de la seconde moitié du XIXème siècle. Ces ouvrages d'art sont donc en service depuis plus d’un siècle et nécessitent une politique de maintenance adaptée. En collaboration avec SNCF Réseau, cette thèse de doctorat apporte des éléments de compréhension sur le comportement mécanique des assemblages rivetés à chaud sous sollicitations monotones et cycliques. Une stratégie expérimentale a été mise en oeuvre afin d'identifier les mécanismes de ruine des assemblages rivetés. Dans un premier temps, le matériau objet de cette étude, un fer puddlé, a été extrait d'éléments provenant du pont sur l'Adour à Bayonne (1864-2013). Ce matériau a été notamment caractérisé sous chargements monotones et cycliques ; sa fragilité, son anisotropie et son comportement dispersif ont été mis en évidence et analysés. Des outils numériques ont été développés pour l’étude microscopique de cette famille de matériaux. Des éprouvettes rivetées de type détail constructif ont par la suite été conçues, fabriquées et testées sous chargements monotones et cycliques. Un scénario précis du fonctionnement et de ruine d'un assemblage mono-rivet en double recouvrement a pu être identifié. Pour cela, les influences des caractéristiques matériau, des concentrations de contraintes, du cisaillement du rivet et de l'effort de serrage ont été étudiées. Les résultats de ce travail, comparés à ceux de la littérature et aux standards de dimensionnement des structures métalliques, montrent la complémentarité d'une étude à plusieurs échelles (comportement matériau et étude locale du fonctionnement des assemblages) dans le but de comprendre et estimer le comportement des structures rivetées anciennes

Contribution to the understanding of the mechanical behaviour of aged hot-riveted assemblies

Le patrimoine ferroviaire français comporte de nombreux ponts métalliques, principalement construits au cours de la seconde moitié du XIXème siècle. Ces ouvrages d'art sont donc en service depuis plus d’un siècle et nécessitent une politique de maintenance adaptée. En collaboration avec SNCF Réseau, cette thèse de doctorat apporte des éléments de compréhension sur le comportement mécanique des assemblages rivetés à chaud sous sollicitations monotones et cycliques. Une stratégie expérimentale a été mise en oeuvre afin d'identifier les mécanismes de ruine des assemblages rivetés. Dans un premier temps, le matériau objet de cette étude, un fer puddlé, a été extrait d'éléments provenant du pont sur l'Adour à Bayonne (1864-2013). Ce matériau a été notamment caractérisé sous chargements monotones et cycliques ; sa fragilité, son anisotropie et son comportement dispersif ont été mis en évidence et analysés. Des outils numériques ont été développés pour l’étude microscopique de cette famille de matériaux. Des éprouvettes rivetées de type détail constructif ont par la suite été conçues, fabriquées et testées sous chargements monotones et cycliques. Un scénario précis du fonctionnement et de ruine d'un assemblage mono-rivet en double recouvrement a pu être identifié. Pour cela, les influences des caractéristiques matériau, des concentrations de contraintes, du cisaillement du rivet et de l'effort de serrage ont été étudiées. Les résultats de ce travail, comparés à ceux de la littérature et aux standards de dimensionnement des structures métalliques, montrent la complémentarité d'une étude à plusieurs échelles (comportement matériau et étude locale du fonctionnement des assemblages) dans le but de comprendre et estimer le comportement des structures rivetées anciennes.Numerous metallic bridges can be found in the French railway heritage. Since a majority of these structures was built during the second half of the 19th century, they have been in service for over a hundred years and need an adapted maintenance policy.These doctoral thesis, done in collaboration with SNCF Réseau, improves the understanding of the mechanical behaviour of hot riveted assemblies under monotonic and cyclic loadings. An experimental strategy was proposed and carried out in order to identify the failure mechanisms of riveted assemblies. First, the studied material, a puddled iron, was obtained from recovered elements from the bridge over the Adour river in Bayonne (1864-2013). Mechanical testing and characterisation was performed under monotonic and cyclic loadings. Puddled iron’s brittle, anisotropic and scattered behaviour was observed and analysed. In-house software applications were developed in order to study this kind of material. Additionally, hot riveted specimens (constructional details) were designed, manufactured and tested under monotonic and cyclic loadings. A precise working (and failure) scenario of the double shear mono-rivet assembly was identified. The influence of the material’s behaviour, stress concentrators, shearing of the rivet and clamping force of the rivet were studied. The results obtained during these research works, compared to the ones found in academic literature as well as construction norms for metallic structures, showed the importance and complementarity of a multi-scale approach (material behaviour and local study of assemblies) in order to understand and assess the behaviour of ancient riveted structures