94 research outputs found
Patient experience of home and waiting room blood pressure measurement: a qualitative study of patients with recently diagnosed hypertension
- Author
- Publication venue
- 'Royal College of General Practitioners'
- Publication date
- 01/01/2018
- Field of study
Background Out-of-office blood pressure (BP) measurement is advocated to confirm hypertension diagnosis. However, little is known about how primary care patients view and use such measurement.Aim To investigate patient experience of out-of-office BP monitoring, particularly home and practice waiting room BP measurement, before, during, and after diagnosis.Design and setting A cross-sectional, qualitative study with patients from two UK GP surgeries participating in a feasibility study of waiting room BP measurement.Method Interviewees were identified from recent additions to the practice hypertension register. Interviews were recorded, transcribed, and coded thematically.Results Of 29 interviewees, 9 (31%) and 22 (76%) had used the waiting room monitor and/or monitored at home respectively. Out-of-office monitoring was used by patients as evidence of control or the lack of need for medication, with the printed results slips from the waiting room monitor perceived to improve ‘trustworthiness’. The waiting room monitor enabled those experiencing uncertainty about their equipment or technique to double-check readings. Monitoring at home allowed a more intensive and/or flexible schedule to investigate BP fluctuations and the impact of medication and lifestyle changes. A minority used self-monitoring to inform drug holidays. Reduced intensity of monitoring was reported with both modalities following diagnosis as initial anxiety or patient and GP interest decreased.Conclusion Home and practice waiting room measurements have overlapping but differing roles for patients. Waiting room BP monitors may be a useful out-of-office measurement modality for patients unwilling and/or unable to measure and record their BP at home
Preconceptional Folate Supplementation and the Risk of Spontaneous Preterm Birth: A Cohort Study
- Author
- A Dhur
- AE Czeizel
- AF Fleming
- AF Fleming
- BA Haider
- C Courtemanche
- Christine H. Comstock
- David A. Nyberg
- DH Charles
- DW Hosmer
- EB Fonseca
- FD Malone
- Fergal D. Malone
- FH Bloomfield
- Flint T. Porter
- G Tchernia
- Gary D. V. Hankins
- GC Smith
- GM Shaw
- GM Shaw
- GR Alexander
- Honor M. Wolfe
- I Blot
- Ilan E. Timor-Tritsch
- J Fletcher
- J Fletcher
- J Lumley
- JD Martin
- JD Martin
- JD Martin
- JM Dodd
- JR Petrini
- K Mahomed
- Keith Eddleman
- KM Laurence
- L Poston
- LB Finer
- Lorraine Dugoff
- Mary E. D'Alton
- MG Whiteside
- MG Whiteside
- MJ Watson
- MR Malinow
- MR Malinow
- N Baumslag
- N Baumslag
- Nicholas M. Fisk
- P Christian
- P Christian
- P Christian
- P Christian
- P Christian
- P Christian
- PF Giles
- PF Giles
- PJ Meis
- PM Grambsch
- PN Kirke
- R Bukowski
- R Bukowski
- RA Jackson
- Radek Bukowski
- RL Goldenberg
- RL Goldenberg
- S May
- Sabrina D. Craigo
- SJ Pocock
- SM Engel
- Stephen R. Carr
- Susan J. Gross
- TO Scholl
- WG Johnson
- X Wang
- X Wang
- X Wang
- Publication venue
- Public Library of Science
- Publication date
- 01/01/2009
- Field of study
In an analysis of a cohort of pregnant women, Radek Bukowski and colleagues describe an association between taking folic acid supplements and a reduction in the risk of preterm birth
MED12 Alterations in Both Human Benign and Malignant Uterine Soft Tissue Tumors
- Author
- Agnès Neuville
- Agnès Ribeiro
- Anne Floquet
- B Döring
- BP Lewis
- C Morey
- CDM Fletcher
- CK Jung
- DJ Taatjes
- DM Lowell
- DN Markowski
- DR Herbold
- E D'Angelo
- Eberhard Stoeckle
- EM Je
- F Chibon
- Frédéric Chibon
- G Hostetter
- G Kir
- Gaëlle Pérot
- Gaëtan MacGrogan
- H Yanai
- J Scurry
- J Szymanska
- J Zavadil
- JC Hodge
- Jean-Michel Coindre
- K Han
- K Hashimoto
- K Mittal
- K Mittal
- KR Mittal
- M Pelmus
- M Uchida
- MM McGuire
- N Mäkinen
- Oliva E
- P Lagarde
- P Zhang
- Pauline Lagarde
- PP Rocha
- Q Qiao
- RA Canevari
- RC Conaway
- RD Mashal
- Rossella Rota
- S Kim
- S Leibsohn
- S Okolo
- S Salas
- Sabrina Croce
- SJ Robboy
- SW Bell
- SY Lin
- TL Ng
- Valérie Velasco
- W Kildal
- WR Hart
- YL Cho
- Publication venue
- Public Library of Science
- Publication date
- 29/06/2012
- Field of study
The relationship between benign uterine leiomyomas and their malignant counterparts, i.e. leiomyosarcomas and smooth muscle tumors of uncertain malignant potential (STUMP), is still poorly understood. The idea that a leiomyosarcoma could derive from a leiomyoma is still controversial. Recently MED12 mutations have been reported in uterine leiomyomas. In this study we asked whether such mutations could also be involved in leiomyosarcomas and STUMP oncogenesis. For this purpose we examined 33 uterine mesenchymal tumors by sequencing the hot-spot mutation region of MED12. We determined that MED12 is altered in 66.6% of typical leiomyomas as previously reported but also in 11% of STUMP and 20% of leiomyosarcomas. The mutated allele is predominantly expressed in leiomyomas and STUMP. Interestingly all classical leiomyomas exhibit MED12 protein expression while 40% of atypical leiomyomas, 50% of STUMP and 80% of leiomyosarcomas (among them the two mutated ones) do not express MED12. All these tumors without protein expression exhibit complex genomic profiles. No mutations and no expression loss were identified in an additional series of 38 non-uterine leiomyosarcomas. MED12 mutations are not exclusive to leiomyomas but seem to be specific to uterine malignancies. A previous study has suggested that MED12 mutations in leiomyomas could lead to Wnt/β-catenin pathway activation however our immunohistochemistry results show that there is no association between MED12 status and β-catenin nuclear/cytoplasmic localization. Collectively, our results show that subgroups of benign and malignant tumors share a common genetics. We propose here that MED12 alterations could be implicated in the development of smooth muscle tumor and that its expression could be inhibited in malignant tumors
Real-world experience of nintedanib for progressive fibrosing interstitial lung disease in the UK
- Author
- Adamali Huzaifa
- Agnew Sarah
- Ahmad Mahin
- Aigbirior Joshua
- Barratt Shaney L.
- Barth Sarah
- Beirne Paul
- Bianchi Stephen
- Bikmalla Shiva
- Bradley Jessica
- Butcher Elizabeth
- Chalmers Jodie
- Chong Sy Giin
- Chua Felix
- Coker Robina K.
- Connon Roisin
- Crawshaw Anjali
- Crowley Louise E.
- Dixon Giles
- Dosanjh Davinder
- Fahim Ahmed
- Fletcher Sophie V.
- Forrest Ian A.
- Garfoot Theresa
- Gatheral Timothy
- George Peter M.
- Gibbons Michael A.
- Grimes Ian
- Hague Samuel
- Hart Simon
- Huntley Christopher C.
- John Alexander
- Jones Mark G.
- Khan Fasihul
- Khin Aye Myat Noe
- Kinsella Emma
- Kokosi Maria
- Kouranos Vasileios
- Kular Raman
- Lawrence Alexandra
- Liu HuaJian
- Minnis Paul
- Molyneaux Philip
- Mulholland Sarah
- Murtagh Eoin
- Muthusami Raja
- Naftel Jennifer
- Naqvi Marium
- Newman Kate
- Nicol Lisa M.
- Plum Catherine
- Renzoni Elisabetta
- Rivera-Ortega Pilar
- Rodrigues Jonathan C.L.
- Rowan Catherine
- Saini Gauri
- Scotton Chris J.
- Simpson A. John
- Spencer Lisa G.
- Stone Helen
- Stranks Lachlan
- Thould Hannah
- Toor Sameen
- Tsaneva-Atanasova Krasimira
- Vitri Benedetta
- Walters Gareth I.
- Ward Katie
- Wells Athol U.
- West Alex
- Wickremasinghe Melissa
- Wilson Andrew M.
- Wood Nicola
- Yazbeck Leda
- Zulfikar Sabrina
- Publication venue
- European Respiratory Society
- Publication date
- 15/01/2024
- Field of study
Background Nintedanib slows progression of lung function decline in patients with progressive fibrosing (PF) interstitial lung disease (ILD) and was recommended for this indication within the United Kingdom (UK) National Health Service in Scotland in June 2021 and in England, Wales and Northern Ireland in November 2021. To date, there has been no national evaluation of the use of nintedanib for PF-ILD in a real-world setting.Methods 26 UK centres were invited to take part in a national service evaluation between 17 November 2021 and 30 September 2022. Summary data regarding underlying diagnosis, pulmonary function tests, diagnostic criteria, radiological appearance, concurrent immunosuppressive therapy and drug tolerability were collected via electronic survey.Results 24 UK prescribing centres responded to the service evaluation invitation. Between 17 November 2021 and 30 September 2022, 1120 patients received a multidisciplinary team recommendation to commence nintedanib for PF-ILD. The most common underlying diagnoses were hypersensitivity pneumonitis (298 out of 1120, 26.6%), connective tissue disease associated ILD (197 out of 1120, 17.6%), rheumatoid arthritis associated ILD (180 out of 1120, 16.0%), idiopathic nonspecific interstitial pneumonia (125 out of 1120, 11.1%) and unclassifiable ILD (100 out of 1120, 8.9%). Of these, 54.4% (609 out of 1120) were receiving concomitant corticosteroids, 355 (31.7%) out of 1120 were receiving concomitant mycophenolate mofetil and 340 (30.3%) out of 1120 were receiving another immunosuppressive/modulatory therapy. Radiological progression of ILD combined with worsening respiratory symptoms was the most common reason for the diagnosis of PF-ILD.Conclusion We have demonstrated the use of nintedanib for the treatment of PF-ILD across a broad range of underlying conditions. Nintedanib is frequently co-prescribed alongside immunosuppressive and immunomodulatory therapy. The use of nintedanib for the treatment of PF-ILD has demonstrated acceptable tolerability in a real-world setting
Whole-genome sequencing reveals host factors underlying critical COVID-19
- Author
- Abd Elghafar M. S.
- Abdel-Aziz M.
- Abdelrazik M.
- Abdollahi H.
- Abdullah T.
- Abecasis G. R.
- Abedalthagafi M.
- Abel L.
- Abernathy C.
- Abraheem A.
- Abul-Husn N. S.
- Acquilini D.
- Adams C.
- Adams E. L.
- Adams K.
- Adamsara A.
- Adanini O.
- Adeleye O.
- Adra D.
- Afilalo J.
- Afilalo M.
- Afolabi D.
- Afrasiabi Z.
- Agasou A.
- Agrawal S.
- Aguero D.
- Ahmad N.
- Ahmadi S.
- Ahmed A.
- Ahmed C.
- Akeroyd L.
- Akhtar M. N.
- Akinkugbe O.
- Aksentijevich A.
- Al-Afghani H.
- Al-Awdah L.
- Alaamery M.
- Alahmadey Z. Z.
- Alaverdian D.
- Alavere H.
- Albader A.
- Albaiceta G. M.
- Albakri J. K.
- AlBardis H.
- Albeladi M.
- Albesher N.
- Albrich W.
- AlDhawi N.
- Aldridge J.
- Aleagha A. E.
- Alexander P.
- Alfonso J.
- Alghamdi B.
- Alghamdi J.
- Ali A.
- Ali A.
- Ali I. A. M.
- Ali S.
- Aliannejad R.
- Aljawini N.
- AlJohani S.
- Alkwai S.
- Allan A.
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- Allan J.
- Alldis Z.
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- AlMalik A.
- Almalki F.
- Almohammed I.
- Almutairi M.
- Alotaibi S.
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- Wyllie D. H.
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- Zhou W.
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- Zlatopolsky M.
- Zollner S.
- Zongo O.
- Zucchi P.
- Zyndorf M.
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2022
- Field of study
Critical COVID-19 is caused by immune-mediated inflammatory lung injury. Host genetic variation influences the development of illness requiring critical care1 or hospitalization2–4 after infection with SARS-CoV-2. The GenOMICC (Genetics of Mortality in Critical Care) study enables the comparison of genomes from individuals who are critically ill with those of population controls to find underlying disease mechanisms. Here we use whole-genome sequencing in 7,491 critically ill individuals compared with 48,400 controls to discover and replicate 23 independent variants that significantly predispose to critical COVID-19. We identify 16 new independent associations, including variants within genes that are involved in interferon signalling (IL10RB and PLSCR1), leucocyte differentiation (BCL11A) and blood-type antigen secretor status (FUT2). Using transcriptome-wide association and colocalization to infer the effect of gene expression on disease severity, we find evidence that implicates multiple genes—including reduced expression of a membrane flippase (ATP11A), and increased expression of a mucin (MUC1)—in critical disease. Mendelian randomization provides evidence in support of causal roles for myeloid cell adhesion molecules (SELE, ICAM5 and CD209) and the coagulation factor F8, all of which are potentially druggable targets. Our results are broadly consistent with a multi-component model of COVID-19 pathophysiology, in which at least two distinct mechanisms can predispose to life-threatening disease: failure to control viral replication; or an enhanced tendency towards pulmonary inflammation and intravascular coagulation. We show that comparison between cases of critical illness and population controls is highly efficient for the detection of therapeutically relevant mechanisms of disease
Common, low-frequency, rare, and ultra-rare coding variants contribute to COVID-19 severity
- Author
- A. Abraheem
- A. Agasou
- A. Ahmed
- A. Ali
- A. Allan
- A. Altabaibeh
- A. Alvaro
- A. Aspinwall
- A. Ayers
- A. Bamford
- A. Barron
- A. Bashyal
- A. Bellini
- A. Bociek
- A. Botello
- A. Bowes
- A. Brady
- A. Brayne
- A. Brown
- A. Brown
- A. Butler
- A. Carter
- A. Collins
- A. Cowley
- A. Cowton
- A. Cowton
- A. Cox
- A. Crew
- A. Dance
- A. Daniel
- A. Daniels
- A. Dela Rosa
- A. Drummond
- A. Durie
- A. E. Heron
- A. Easthope
- A. Easthorpe
- A. Evans.
- A. Fofano
- A. Gales
- A. Ganesan
- A. Gardner
- A. Garg
- A. Gherman
- A. Gordon
- A. Gratrix
- A. Gulati
- A. Gupta
- A. Haigh
- A. Haldeos
- A. Harrison
- A. Harvey
- A. Hayes
- A. Higham
- A. Higham
- A. Hilldrith
- A. Holden
- A. Hormis
- A. Hutcheon
- A. Javaid
- A. Joseph
- A. Kaliappan
- A. Katary
- A. Kay
- A. Kayani
- A. Kent
- A. Kirkby
- A. Knight
- A. Kubisz-Pudelko
- A. Kuravi
- A. Lewis
- A. Loveridge
- A. Lyle
- A. Mayer
- A. McAlpine
- A. McCarthy
- A. McGregor
- A. McGregor
- A. Meikle
- A. Mitchell
- A. Mitra
- A. Morris
- A. Morrison
- A. Naranjo
- A. Nicholson
- A. Nicholson
- A. Noakes
- A. Patel
- A. Pickard
- A. Price
- A. Puxty
- A. Quinn
- A. Quinn
- A. Raithatha
- A. Rattray
- A. Reddy
- A. Reed
- A. Reyes
- A. Rose
- A. Rose
- A. Rostron
- A. Roy
- A. Roynon-Reed
- A. S. Raj
- A. Salberg
- A. Sanderson
- A. Serrano-Ruiz
- A. Solesbury
- A. Sukha
- A. Swain
- A. Tariq
- A. Thomas
- A. Thomas
- A. Todd
- A. Tomas
- A. Tridente
- A. Tucci
- A. Turnbull
- A. Uriel
- A. Ustianowski
- A. Vochin
- A. Vuylsteke
- A. Waite
- A. Walden
- A. Whileman
- A. Wilkinson
- A. Williams
- A. Williams
- A. Wilson
- A. Zak
- A. Zaki
- Achille Iolascon
- Adam Brown
- Adam Krętowski
- Adriana Roży
- Agnese Verzuri
- Agnieszka Adamek
- Agnieszka Bielska
- Agostino Ognibene
- Agostino Riva
- Ailsa Golightly
- Alan Maclean
- Albert Tenesa
- Aleksandra Berkan-Kawinska
- Aleksandra Jezela-Stanek
- Aleksandra Starosz
- Alessandra Guarnaccia
- Alessandra Renieri &
- Alessandra Stella
- Alessandra Vergori
- Alessandro Pancrazzi
- Alessia Giorli
- Alice Donati
- Alison Meynert
- Alistair Nichol
- Anders Larsson
- Andrea Antinori
- Andrea Cossarizza
- Andrea Gabbuti
- Andrea Tommasi
- Andrew D. Bretherick
- Andrew Law
- Andrew Stenhouse
- Andrzej Eljaszewicz
- Andrzej Horban
- Andy Law
- Angelica Pagliazzi
- Angie Fawkes
- Anke Hinney
- Anna Canaccini
- Anna Kruk
- Anna Maria Pinto
- Anna Moniuszko-Malinowska
- Anna Parfieniuk-Kowerda
- Anna Piekarska
- Anna Szałkowska
- Annarita Giliberti
- Anne Richmond
- Antonella D. ’Arminio Monforte
- Antonella Vincenti
- Antonia Ho
- Antonio Di Biagio
- Antonio Perrella
- Arianna Emiliozzi
- Arianna Gabrieli
- Arsalin Azzadin
- Asma Al Thani &
- Athanasios Kousathanas
- Audrey Coutts
- Axel Schmidt
- Axel Schmidt
- B. Anwar
- B. Attwood
- B. Baines
- B. Blackledge
- B. Borislavova
- B. Chandler
- B. Charles
- B. Creagh-Brown
- B. David
- B. Deacon
- B. Deacon
- B. Digby
- B. Faulkner
- B. Fuller
- B. Gumbrill
- B. Gurung
- B. Hadebe
- B. Hairsine
- B. Hopkins
- B. Johnson
- B. Lenagh
- B. Masunda
- B. Ogg
- B. Patel
- B. Player
- B. Purewal
- B. Scholefield
- B. Shelley
- B. Sloan
- B. Thomas
- B. Wadams
- B. Welsh
- B. Wilkinson
- B. Winter-Goodwin
- B. Yates
- Barbara Rossetti
- Barbara Shih
- Barbara Sobala-Szczygiel
- Beata Puzanowska
- Benedetta Romanin
- Björn Jensen
- Bo Wang
- Brent Richards
- Bruno Frediani
- C. Adams
- C. Ahmed
- C. Almaden-Boyle
- C. Ashbrook-Raby
- C. Basikolo
- C. Battle
- C. Beazley
- C. Beith
- C. Borra
- C. Brandwood
- C. Brantwood
- C. Burnett
- C. Castro Delgado
- C. Clark
- C. Clulow
- C. Collins
- C. Cruz
- C. Davis
- C. Demetriou
- C. Dennis
- C. Dexter
- C. Downes
- C. Eastgate
- C. Finch
- C. Gibson
- C. Gorman
- C. Hays
- C. Hewitt
- C. Holl
- C. Howcroft
- C. Humphrey
- C. Jackson
- C. Jardine
- C. Jennings
- C. Jones
- C. Kaye
- C. Lynch
- C. Lyons
- C. McCulloch
- C. McParland
- C. McParland
- C. Murphy
- C. Parmar
- C. Pawley
- C. Phillips
- C. Phillips
- C. Pothecary
- C. Pothecary
- C. Prendergast
- C. Price
- C. Rishton
- C. Shovelton
- C. Sicat
- C. Stuart
- C. Summers
- C. Swan
- C. Thompson
- C. Thorpe
- C. Tibke
- C. Tierney
- C. Vigurs
- C. Wells
- C. Whitton
- C. Whyte
- C. Wrey Brown
- Carlo Maj
- Carmelo Piscopo
- Caroline Abernathy
- Caterina Lo Rizzo
- Ce Dunmore
- Cecilia Costa
- Ceilia Boz
- Cesira Nencioni
- Chadi Saad
- Charles Hinds
- Charlotte Summers
- Chenqing Zheng
- Chiara Barbieri
- Chiara Fallerini
- Chiara Gabbi
- Chiara Spertilli Raffaelli
- Chris P. Ponting
- Chris Ponting
- Christian Herr
- Christof Winter
- Christoph D. Spinner
- Clark D. Russell
- Claudia Suardi
- Claudio Ferri
- Clemens M. Wendtner
- Cristina Mussini
- D. Antcliffe
- D. Bakthavatsalam
- D. Banach
- D. Baptista
- D. Bell
- D. Branney
- D. Brealey
- D. Brealey
- D. Butcher
- D. Butcher
- D. Childs
- D. Clarke
- D. Collier
- D. Collier
- D. Cristiano
- D. Dawson
- D. Donaldson
- D. Duffin
- D. Golden
- D. Griffin
- D. Hawcutt
- D. Hope
- D. Horner
- D. Kallon
- D. Kaye
- D. Kelly
- D. Loader
- D. Lomas
- D. Martin
- D. McGlynn
- D. McLaughlanv
- D. Melia
- D. Menzies
- D. Mullan
- D. Pogson
- D. Potla
- D. Potoczna
- D. Purohit
- D. Raynard
- D. Salutous
- D. Salutous
- D. Scaletta
- D. Shaw
- D. Skinner
- D. Smyth
- D. Strachan
- D. Tetla
- D. Thornton
- D. Trodd
- D. Vedage
- D. Walker
- D. Warren
- D. Williams
- D. Wood
- D. Wright
- Daniela Francisci
- Danilo Tacconi
- Danny McAuley
- David Bennett
- David Harrison
- David Maslove
- Davide Grassi
- Davide Romani
- Dawn Law
- Diana Alaverdian
- Diana Martonik
- Diego Ripamonti
- Domenico A. Coviello
- Dorota Pasko
- Dorota Zarębska-Michaluk
- E. Abaleke
- E. Allan
- E. Anastasescu
- E. Andrews
- E. Apetri
- E. Beech
- E. Beranova
- E. Bevan
- E. Black
- E. Brinkworth
- E. Collins
- E. Combes
- E. Davies
- E. Dobson
- E. Dooks
- E. Fisher
- E. Gendall
- E. Goff
- E. Goodwin
- E. Gordon
- E. Heeney
- E. Horsley
- E. Hughes
- E. Johnson
- E. Jude
- E. Knights
- E. Lee
- E. London
- E. Maccacari
- E. Massey
- E. McKenna
- E. Meadows
- E. Moncur
- E. Morino
- E. Mwaura
- E. Peasgood
- E. Perkins
- E. Radford
- E. Raith
- E. Salciute L. Grauslyte
- E. Smith
- E. Smithson
- E. Stoddard
- E. Stones
- E. Thomas
- E. Tilney
- E. Timlick
- E. Treus Gude
- E. Virgilio
- E. Watson
- E. Wilby
- E. Wraith
- Edoardo Conticini
- Elena Andreucci
- Elena Bargagli
- Elena Desanctis
- Elisa Benetti
- Elisa Frullanti
- Elisabetta Menatti
- Elisabetta Schiaroli
- Ellie Mcmaster
- Elvina Gountouna
- Emanuele Catena
- Enrico Cabri
- Enrico Martinelli
- Erika Fiorentini
- Erola Pairo-Castineira
- Erola Pairo-Castineira
- Esther Duncan
- Eugenia Quiros-Roldan
- Eva C. Schulte
- Eva C. Schulte
- F. Anderson
- F. Auld
- F. Bibi
- F. Davies
- F. Farquhar
- F. Fisher
- F. Hurford
- F. Kibutu
- F. McNeela
- F. Moore
- F. Nasir
- F. Trim
- F. Wakinshaw
- F. Williams
- Fabian Brand
- Fabio Lena
- Faisal Almalki
- Federica Gaia Miraglia
- Federico Anedda
- Federico Franchi
- Ferdinando Giannattasio
- Filip Taneski
- Filippo Aucella
- Filippo Biscarini
- Fiona Griffiths
- Floriana Valentino
- Francesca Andretta
- Francesca Ariani
- Francesca Colombo
- Francesca Fava
- Francesca Gatti
- Francesca Mari
- Francesca Minnai
- Francesca Montagnani
- Francesca Vichi
- Francesco Bianchi
- Francesco Brancati
- Francesco Castelli
- Francesco Menichetti
- Francesco Paciosi
- Francesco Raimondi
- Francesco Vladimiro Segala
- Francis P. Crawley
- Franco Maggiolo
- Franco Marinangeli
- G. Andrew
- G. Arbane
- G. Bell
- G. Bercades
- G. Croston
- G. Debreceni
- G. Durrant
- G. Hambrook
- G. Hobden
- G. Houston
- G. Hughes
- G. Jones
- G. Lubimbi
- G. Maloney
- G. Martir
- G. Millen
- G. Mills
- G. O’Connor
- G. Randell
- G. Sadera
- G. Seddon
- G. Sera Howe
- G. Sloane
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- V. Amin
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- V. Bastion
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- V. Crickmore
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- Veronique Vitart
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- W. Khaliq
- W. McCormick
- W. Woodyatt
- Wadha Al-Muftah
- WES/WGS Working Group Within the HGI
- Wiktoria Izdebska
- Wilna Oosthuyzen
- X. Qiu
- Xia Shen
- Y. Baird
- Y. Choudhury
- Y. Hussain
- Y. Jackson
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- Yanara Marincevic-Zuniga
- Yang Wu
- Yaser Al-Sarraj
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- Z. Belagodu
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- Z. Daly
- Z. Farzad
- Z. Fernandez
- Z. Garland
- Z. Maqsood
- Z. Omar
- Z. Prime
- Z. Scott
- Zhijian Yang
- Publication venue
- Publication date
- 01/01/2022
- Field of study
The combined impact of common and rare exonic variants in COVID-19 host genetics is currently insufficiently understood. Here, common and rare variants from whole-exome sequencing data of about 4000 SARS-CoV-2-positive individuals were used to define an interpretable machine-learning model for predicting COVID-19 severity. First, variants were converted into separate sets of Boolean features, depending on the absence or the presence of variants in each gene. An ensemble of LASSO logistic regression models was used to identify the most informative Boolean features with respect to the genetic bases of severity. The Boolean features selected by these logistic models were combined into an Integrated PolyGenic Score that offers a synthetic and interpretable index for describing the contribution of host genetics in COVID-19 severity, as demonstrated through testing in several independent cohorts. Selected features belong to ultra-rare, rare, low-frequency, and common variants, including those in linkage disequilibrium with known GWAS loci. Noteworthily, around one quarter of the selected genes are sex-specific. Pathway analysis of the selected genes associated with COVID-19 severity reflected the multi-organ nature of the disease. The proposed model might provide useful information for developing diagnostics and therapeutics, while also being able to guide bedside disease management. © 2021, The Author(s)
Multi-messenger observations of a binary neutron star merger
- Author
- Aab A
- Aartsen MG
- Abbott BP
- Abbott R
- Abbott TD
- Abbott TMC
- Abdalla H
- Abe F
- Abeysekara AU
- Abramo LR
- Abramowski A
- Abreu P
- Acernese F
- Acero F
- Ackermann M
- Ackley K
- Ackley K
- Adams C
- Adams J
- Adams SM
- Adams T
- Addesso P
- Adhikari RX
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- Perri M
- Perrina C
- Perrodin D
- Perrone L
- Pescalli A
- Pesce-Rollins M
- Peters C
- Peters WM
- Petrera S
- Petrucci P-O
- Peyaud B
- Pfeiffer HP
- Phelps M
- Phlhofer G
- Phuntsok J
- Pian E
- Piano G
- Piattelli P
- Piccinni OJ
- Pichot M
- Picozza P
- Piel Q
- Pieloth D
- Piergiovanni F
- Pierog T
- Pierro V
- Pignata G
- Pike S
- Pilia M
- Pillant G
- Pimenta M
- Pinard L
- Pinat E
- Pinto IM
- Piotrowski LW
- Piran T
- Piran T
- Piranomonte S
- Pirello M
- Piro AL
- Piro L
- Piron F
- Pirronello V
- Pisanu T
- Pita S
- Pitkin M
- Pittori C
- Placco VM
- Platino M
- Plazas AA
- Plum M
- Podesta F
- Podesta RC
- Podsiadlowski P
- Poe M
- Poggiani R
- Poh J
- Poireau V
- Pollmann A Obertacke
- Poolakkil S
- Poon H
- Popa V
- Popolizio P
- Poppi S
- Porowski C
- Porter EK
- Porter TA
- Possenti A
- Post A
- Potter SB
- Powell J
- Pozanenko AS
- Poznanski D
- Pradier T
- Prado RR
- Prasad J
- Pratt JWW
- Pratten G
- Predoi V
- Preece RD
- Prentice SJ
- Prestegard T
- Pretz J
- Price LR
- Price PB
- Prijatelj M
- Principe G
- Principe M
- Pritchard TA
- Privitera P
- Privitera S
- Prochaska JX
- Prodi GA
- Prokhorov D
- Prokhorov LG
- Prokoph H
- Prouza M
- Prrer M
- Przybylski GT
- Pulone L
- Pumo ML
- Punch M
- Puncken O
- Punturo M
- Puppo P
- Qi H
- Qi H
- Qu JL
- Quataert E
- Quel EJ
- Querchfeld S
- Querel R
- Quetschke V
- Quimby RM
- Quinn L
- Quinn S
- Quinones C
- Quintero EA
- Quirrenbach A
- Quispe ID Vergara
- Quitzow-James R
- Raab C
- Raab FJ
- Raab S
- Rabeling DS
- Rabus M
- Racca C
- Racusin J
- Radkins H
- Raffai P
- Rain S
- Raja S
- Raja W
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- Rakhmanov M
- Rameez M
- Ramirez KE
- Ramirez-Ruiz E
- Ramos-Buades A
- Ramos-Pollan R
- Rana J
- Rando R
- Rao AR
- Rapagnani P
- Rappoldi A
- RATIR RIMAS
- Rau A
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- Rauth R
- Ravignani D
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- Raymond V
- Razza A
- Razzano M
- Razzano M
- Razzaque S
- Rdel L
- Rdiger A
- Rea IC
- Read J
- Rebolo R
- Regimbau T
- Rei L
- Reichart DE
- Reid S
- Reimann R
- Reimer A
- Reimer A
- Reimer O
- Reimer O
- Reitze DH
- Relethford B
- Relich M
- Ren W
- Ren Z
- Renaud M
- Renzi V
- Reposeur T
- Resconi E
- Resmi L
- Rest A
- Reva IV
- Reyes R De Los
- Reyes SD
- Reynolds T
- Rho CD
- Rhode W
- Ribeiro T
- Ricci F
- Ricci R
- Ricciarini S
- Riccobene G
- Richman M
- Ricker PM
- Ridden-Harper R
- Ridky J
- Rieger F
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- Riguccini L
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- Rinchiuso L
- Rios-Lopez E
- Risse M
- Ristori P
- Rivera A Ramirez
- Riviere C
- Rizi V
- Rizzo M
- Roberts OJ
- Robertson NA
- Robertson S
- Robie R
- Robinet F
- Rocchi A
- Rochester LS
- Rodi J
- Rodriguez H
- Rojas D Avila
- Rojas-Bravo C
- Rojo J Rodriguez
- Rol E
- Rolland L
- Rollins JG
- Roma VJ
- Romano R
- Romel CL
- Romer AK
- Romero M Dominguez
- Romie JH
- Romoli C
- Roncoroni MJ
- Rongen M
- Roodman A
- Roques J-P
- Rosa-Gonzlez D
- Rosell A Carnero
- Rosenberg M
- Rosetti S
- Rosinska D
- Ross MP
- Rossi A
- Rosswog S
- Rosswog S
- Roth M
- Rott C
- Roulet E
- Rovero AC
- Rowan S
- Rowell G
- Rowlinson A
- Rowlinson A
- Roy R
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- Rudak B
- Ruehl P
- Ruggi P
- Ruhe T
- Ruiter AJ
- Ruiz R Gracia
- Ruiz-Velasco E
- Rulten CB
- Rumyantsev VV
- Rusu F
- Rutins G
- Ryan K
- Rybicki KA
- Ryckbosch D
- Rykoff ES
- Rysewyk D
- Saba A
- Sachdev S
- Sadecki T
- Sadeghian L
- Sadler EM
- Sadler EM
- Saffe C
- Saffi SJ
- Saftoiu A
- Sahakian V
- Sai N
- Saito S
- Saito T
- Saito Y
- Sakamaki A
- Sakamoto T
- Sakellariadou M
- Sako M
- Sako S
- Salafia OS
- Salamida F
- Salazar H
- Salazar H
- Salconi L
- Saldaa M
- Saleem M
- Saleh A
- Salemi F
- Salina G
- Salmon L
- Salvadori I
- Salvaterra R
- Samajdar A
- Sammut L
- Sampedro L
- Sampson LM
- Samtleben DFE
- Sanchez B
- Sanchez DA
- Sanchez E
- Sanchez EJ
- Sanchez F
- Sanchez LE
- Sanchez-Losa A
- Sanchez-Lucas P
- Sanchez-Ramirez R
- Sanchis-Gual N
- Sand DJ
- Sandberg V
- Sanders JR
- Sandoval A
- Sandrock A
- Sandroos J
- Sanguineti M
- Sansom EK
- Santander M
- Santangelo A
- Santos E
- Santos EM
- Sapienza P
- Sarazin F
- Sarkar S
- Sarkar S
- Sarmento R
- Sarmiento-Cano C
- Sasaki M
- Sasaki R
- Sassolas B
- Satalecka K
- Sathyaprakash BS
- Sato R
- Saulson PR
- Sauseda M
- Sauter O
- Savage RL
- Savchenko V
- Sawadsky A
- Sbarufatti B
- Scalzo RA
- Scarpine V
- Schady P
- Schale P
- Schauer M
- Scheel M
- Scherini V
- Scheuer J
- Schieler H
- Schimp M
- Schindler R
- Schipani P
- Schlegel DJ
- Schlickeiser R
- Schlunder P
- Schmalz SE
- Schmidt BP
- Schmidt D
- Schmidt J
- Schmidt P
- Schmidt T
- Schnabel R
- Schneider A
- Schneider M
- Schneiter M
- Schoenell W
- Schoenen S
- Schofield RMS
- Scholten O
- Schonbeck A
- Schoneberg S
- Schoorlemmer H
- Schovnek P
- Schreiber E
- Schroder FG
- Schroder S
- Schroder SL
- Schssler F
- Schubnell M
- Schuette D
- Schulte BW
- Schultz ASB
- Schulz A
- Schulz A
- Schulze S
- Schumacher J
- Schumacher L
- Schutz BF
- Schwalbe SG
- Schwanke U
- Schwemmer S
- Schweyer T
- Sciutto SJ
- Scolnic D
- Scott J
- Scott SM
- Secco LF
- Seckel D
- Seglar-Arroyo M
- Segreto A
- Seidel E
- Seitenzahl IR
- Sekiguchi Y
- Sellers D
- Selsing J
- Sengupta AS
- Sentenac D
- Sequino V
- Sergeev A
- Sergienko Yu P
- Serino M
- Serra G
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- Serrau M
- Settimo M
- Seunarine S
- Sevilla-Noarbe I
- Seyffert AS
- Sgro C
- Shaddock DA
- Shadkam A
- Shaffer TJ
- Shafi N
- Shah AA
- Shahriar MS
- Shaner MB
- Shang Z
- Shannon RM
- Shao L
- Shapiro B
- Shappee BJ
- Shara MM
- Sharma I
- Sharp RG
- Shawhan P
- Sheldon E
- Shellard RC
- Sheperd A
- Shidatsu M
- Shilon I
- Shimizu Y
- Shimomukai R
- Shingles LJ
- Shiningayamwe K
- Shoemaker DH
- Shoemaker DM
- Shulevski A
- Siebert MR
- Siegel MH
- Sieger C
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- Siemens X
- Sieniawska M
- Sigg D
- Sigl G
- Silli G
- Silva AD
- Sim SA
- Simon JD
- Simonetti JH
- Simoni R
- Singer LP
- Singh A
- Singhal A
- Sinnis G
- Sintes AM
- Siskind EJ
- Slagmolen BJJ
- Slzer T
- Smartt SJ
- Smida R
- Smirnov OM
- Smith AJ
- Smith B
- Smith JR
- Smith KW
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- Snow GR
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- Sobreira F
- Sodre L
- Soedingrekso J
- Soffitta P
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- Sollerman J
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- Somala S
- Sommers P
- Son EJ
- Song LM
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- Sonnenberg JA
- Sonntag S
- Sorazu B
- Soriano JF
- Sorrentino F
- Souradeep T
- Spada F
- Spandre G
- Spanier F
- Spencer AP
- Spera M
- Spiczak GM
- Spiering C
- Spir-Jacob M
- Springer RW
- Spurio M
- Squartini R
- Srivastava AK
- Staats K
- Stachurska J
- Staff J
- Stagni M
- Stalder B
- Staley A
- Stamatikos M
- Stamerra A
- Stanbro M
- Stanca D
- Stanev T
- Stanic S
- Stanway ER
- Starck M
- Starling RLC
- Stasielak J
- Stasik A
- Stassi P
- Stawarz L
- Stebbins A
- Steeghs DTH
- Steele I
- Steele K
- Steenkamp R
- Stegmann C
- Steinke M
- Steinlechner J
- Steinlechner S
- Steinmeyer D
- Stella L
- Steppa C
- Stettner J
- Steuer A
- Stevenson SP
- Stewart AJ
- Stezelberger T
- Stokstad RG
- Stolarczyk Th
- Stolpovskiy M
- Stone R
- Stops DJ
- Stosl A
- Strafella F
- Strain KA
- Stratta G
- Streich A
- Strigin SE
- Strotjohann NL
- Strunk A
- Stubbs CW
- Sturani R
- Stuttard T
- Stuver AL
- Suarez F
- Suarez-Duran M
- Suchyta E
- Sudholz T
- Sugawara Y
- Sugita S
- Sugizaki M
- Sullivan GW
- Sullivan M
- Sumi T
- Summerscales TZ
- Sun L
- Sun L
- Sun T
- Sunil S
- Suntzeff NB
- Sunyaev R
- Suomijarvi T
- Supanitsky AD
- Supik J
- Surajbali P
- Surcis G
- Suresh J
- Sushch I
- Suson DJ
- Sutherland M
- Sutton PJ
- Svinkin DS
- Swain J
- Swanson MEC
- Swinkels BL
- Szadkowski Z
- Szczepanczyk MJ
- Szegedi H
- Szomoru A
- Taboada A
- Taboada I
- Taborda OA
- Tacca M
- Tachibana Y
- Taddia F
- Tagliaferri G
- Tait SC
- Taiuti M
- Tajitsu A
- Takahashi I
- Takahashi J
- Takahashi M
- Takahashi T
- Takao Y
- Takayama M
- Talbot C
- Talukder D
- Tamura T
- Tamura Y
- Tan Y
- Tanaka I
- Tanaka M
- Tanaka Y
- Tanimoto A
- Tanner DB
- Tanvir NR
- Tao C
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- Tao WH
- Taracchini A
- Tarle G
- Tartaglia L
- Tasson JD
- Tatar J
- Taubenberger S
- Tavani M
- Tavernet J-P
- Tavernier T
- Tayalati Y
- Taylor AM
- Taylor GB
- Taylor JA
- Taylor R
- Team AGILE
- Team Euro VLBI
- Team MAXI
- Team The 1M2H
- Telescope ATCA Australia
- Telescope Fermi Large Area
- Telescope Nordic Optical
- Tello JC
- Telluride AstroSat Cadmium Zinc
- Tenholt F
- Ter Veen S
- Ter-Antonyan S
- Terai T
- Terliuk A
- Terreran G
- Terrier R
- Tesic G
- Testa V
- Tewari SV
- Thayer JB
- Thayer JG
- Theeg T
- Thene CC
- Thierry P
- Thierry P
- Thies F
- Thomas EG
- Thomas M
- Thomas P
- Thomas RC
- Thompson DJ
- Thorne KA
- Thorne KS
- Thrane E
- Tibaldo L
- Tibaldo L
- Tibolla O
- Tilav S
- Timmermans C
- Tingay SJ
- Tiwari S
- Tiwari V
- Tiziani D
- Tjus J Becker
- Tjus J Becker
- Tlatov AG
- Tluczykont M
- Toale PA
- Tobin MN
- Tohuvavohu A
- Tokmakov KV
- Toland K
- Tollefson K
- Toma K
- Tomankova L
- Tomasella L
- Tome B
- Tomida H
- Tominaga N
- Tonelli M
- Tonnis C
- Tonry J
- Torii S
- Tornasi Z
- Tornatore M
- Torres DF
- Torres I
- Torres-Flores S
- Torres-Forn A
- Torresi E
- Torrie CI
- Toscano S
- Tosi D
- Towner MC
- Toyr D
- Tpai M
- Travasso F
- Travnicek P
- Traylor G
- Trichard C
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- Trinastic J
- Tringali MC
- Trini M
- Tristram PJ
- Trois A
- Troja E
- Troja E
- Trott CM
- Trovato A
- Troxel MA
- Trozzo L
- Tsai J
- Tsang KW
- Tse M
- Tselengidou M
- Tsirou M
- Tso R
- Tsuboi Y
- Tsuji N
- Tsukada L
- Tsuna D
- Tsunemi H
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- Tuffs R
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- Tungalag N
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- Turatto M
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- Turley CF
- Turpin D
- Turpin D
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- Ty B
- Tyurina NV
- Ubertini P
- Uchiyama Y
- Ueda Y
- Uemura M
- Ueno K
- Ueno S
- Ugolini D
- Ukwatta TN
- Ulaczyk K
- Ulanov MV
- Ulloa N
- Ulrich R
- Unger E
- Unger M
- Univ Chandra Team McGill
- Univ Texas Tech
- Universe High Time Resolution
- Unnikrishnan CS
- Urban AL
- Urban M
- Ursi A
- Usman SA
- Usner M
- Utsumi Y
- Vacca V
- Vadawale SV
- Vahlbruch H
- Vaisanen P
- Vajente G
- Valdes G
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- Valio I
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- Van der Walt DJ
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- Vander-Hyde DC
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- Vergani D
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- Verkindt D
- Verrecchia F
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- Vibhute A
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- Viets AD
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- Vink J
- Virgo LIGO Sci Collaboration
- Vitale PF Gomez
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- Vivolo D
- Vizzoca A
- Vladimirov VV
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- Vogel E
- Voisin F
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- Vos J
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- Wainscoat RJ
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- Walz D
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- Wave GRAWITA GRAvitational
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- Weiland H
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- Wessel EK
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- Westphal T
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- Whelan JT
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- Wiebusch CH
- Wiedenski M
- Wiencke L
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- Wiersema K
- Wierzcholska A
- Wijers RAMJ
- Wijers RAMJ
- Wilczynski H
- Wilken D
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- Williams PKG
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- Worden J
- Woschnagg K
- Woudt PA
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- Wrochna G
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- Wundheiler B
- Wyrzykowski L
- Wysocki DM
- Xiao GC
- Xiao S
- Xiong SL
- Xu D
- Xu DL
- Xu H
- Xu XW
- Xu Y
- Xu Y
- Xu YP
- Yamada S
- Yamaguchi MS
- Yamamoto H
- Yamaoka K
- Yamaoka K
- Yamauchi M
- Yan L
- Yan LL
- Yancey CC
- Yanez JP
- Yang J
- Yang J
- Yang JW
- Yang L
- Yang L
- Yang R
- Yang S
- Yang S
- Yang YJ
- Yanny B
- Yap MJ
- Yapici T
- Yaron O
- Yasuda N
- Yatabe F
- Yatsu Y
- Yazback M
- Yock PC
- Yodh G
- Yodh GB
- Yoneyama T
- Yoon Y
- Yoshida A
- Yoshida M
- Yoshida S
- Yoshii T
- Young DR
- Younk PW
- Yu Hang
- Yu Haocun
- Yu P-C
- Yuan T
- Yuan X
- Yurkov VV
- Yushkov A
- Yvert M
- Zaborov D
- Zacharias M
- Zadrozny A
- Zadrozny A
- Zaharijas G
- Zaltzman M
- Zanin R
- Zanolin M
- Zaremba M
- Zarnecki AF
- Zas E
- Zavrtanik D
- Zavrtanik M
- Zdziarski AA
- Zech A
- Zefi F
- Zelenova T
- Zendri J-P
- Zenko T
- Zenteno A
- Zepeda A
- Zertuche L Magaa
- Zevin M
- Zhang AM
- Zhang B-B
- Zhang C
- Zhang CL
- Zhang CM
- Zhang F
- Zhang H
- Zhang HM
- Zhang J
- Zhang L
- Zhang M
- Zhang Q
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- Zhang T
- Zhang W
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- Zhang Y
- Zhang Y
- Zhang Y
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- Zhang YF
- Zhang YJ
- Zhang Z
- Zhang ZL
- Zhao C
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- Zhao JL
- Zhao W
- Zhao XF
- Zheng SJ
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- Zhou Z
- Zhu SJ
- Zhu XJ
- Zhu Y
- Zhu YX
- Zhu Z
- Ziegler A
- Zimmerman AB
- Zimmermann B
- Zimnukhov DS
- Ziolkowski M
- Zoll M
- Zong Z
- Zorn J
- Zornoza JD
- Zou CL
- Zuccarello F
- Zucker ME
- Zuniga J
- Zweizig J
- Zywucka N
- Publication venue
- 'American Astronomical Society'
- Publication date
- 01/01/2017
- Field of study
On 2017 August 17 a binary neutron star coalescence candidate (later designated GW170817) with merger time 12:41:04 UTC was observed through gravitational waves by the Advanced LIGO and Advanced Virgo detectors. The Fermi Gamma-ray Burst Monitor independently detected a gamma-ray burst (GRB 170817A) with a time delay of ~1.7 s with respect to the merger time. From the gravitational-wave signal, the source was initially localized to a sky region of 31 deg2 at a luminosity distance of 40+8-8 Mpc and with component masses consistent with neutron stars. The component masses were later measured to be in the range 0.86 to 2.26 Mo. An extensive observing campaign was launched across the electromagnetic spectrum leading to the discovery of a bright optical transient (SSS17a, now with the IAU identification of AT 2017gfo) in NGC 4993 (at ~40 Mpc) less than 11 hours after the merger by the One- Meter, Two Hemisphere (1M2H) team using the 1 m Swope Telescope. The optical transient was independently detected by multiple teams within an hour. Subsequent observations targeted the object and its environment. Early ultraviolet observations revealed a blue transient that faded within 48 hours. Optical and infrared observations showed a redward evolution over ~10 days. Following early non-detections, X-ray and radio emission were discovered at the transient’s position ~9 and ~16 days, respectively, after the merger. Both the X-ray and radio emission likely arise from a physical process that is distinct from the one that generates the UV/optical/near-infrared emission. No ultra-high-energy gamma-rays and no neutrino candidates consistent with the source were found in follow-up searches. These observations support the hypothesis that GW170817 was produced by the merger of two neutron stars in NGC4993 followed by a short gamma-ray burst (GRB 170817A) and a kilonova/macronova powered by the radioactive decay of r-process nuclei synthesized in the ejecta
Basic science232. Certolizumab pegol prevents pro-inflammatory alterations in endothelial cell function
- Author
- Abdulkader Rita
- Abozaid Hanan S.
- Adab Peymané
- Adizie Tochukwu
- Adshead Rebecca
- Ahmad Yasmeen
- Ahmed Azeem A.
- Akil Mohammed
- Alavi Azita
- Alcorn Desmond
- Alexander Yvonne
- Alexander Yvonne
- Alexander Yvonne
- Allen Maggie
- Amarasena Roshan
- Amarasena Roshan I.
- Ambler Nick
- Amft Nicole
- Amft Nicole
- Amissah-Arthur Maame
- Amos Nicholson
- Anderson David
- Andres Mariano
- Andrews Jacqueline
- Arthur Catherine
- Ashton Simon
- Axford John
- Ayalew Yezenash
- Baburaj Krishnan
- Bacon Paul A.
- Baguley Elaine
- Ball Elisabeth
- Banik Snehashish
- Bari Syed F.
- Barone Francesca
- Barone Francesca
- Barton Anne
- Barton Anne
- Basu Neil
- Bateman James
- Bavakunji Riaz
- Bayley Rachel
- Beasley Marcus
- Bell Aubrey
- Bell Aubrey L.
- Birnbaum Julius
- Bombardieri M.
- Bombardieri Michele
- Bombardieri Michele
- Bombardieri Michele
- Bond Christine
- Bond Ursula
- Borg Frances
- Borg Frances A.
- Bosworth Ailsa
- Boulton John
- Bowman Simon
- Bowness Paul
- Bowness Paul
- Bowness Paul
- Braude Simon
- Brooksby Alan
- Brophy Sinead
- Brown Deborah
- Brown Nina
- Brown Sue J.
- Bruce Ian
- Bruce Ian
- Bruce Ian
- Bruce Ian
- Bruce Ian
- Buckley Chris
- Buckley Chris
- Buckley Chris
- Buckley Chris D.
- Bukhari Marwan
- Bukhari Marwan
- Bukhari Marwan
- Bullock Craig
- Bunn Diane
- Bunn Diane
- Bunning Rowena
- Bunning Rowena A. D.
- Bunning Rowena D.
- Calnan Michael
- Cardy Caroline M.
- Casey Matthew
- Caswell Richard
- Ceeraz Sabrina
- Chan Antoni
- Chana Jasroop K.
- Chapman Victoria
- Chen Liye
- Cheng K. K.
- Chitale Sarang
- Chitale Sarang
- Chiverton Neil
- Chiverton Neil
- Choy Ernest
- Choy Ernest H.
- Christidis Dimitrios
- Cloake Tom
- Cloake Tom
- Clunie Gavin
- Coady David
- Coady David
- Coady David
- Colaco Bernard
- Cole Zoe A.
- Coles Mark
- Collins Fraser
- Cooksey Roxanne
- Cooper Annie
- Cooper Cyrus
- Cooper Cyrus
- Cooper Nicola
- Cope Andrew
- Cordingley Lis
- Corrigall Valerie
- Coward Lucy
- Crawford Aileen
- Crilly Anne
- Cross Alison
- Cross Alison K.
- Crouch Carina
- Crozier Sarah R.
- Cumming Jo
- Curtis Elizabeth M.
- D'Cruz David
- Danda Debashish
- Daniel Priya
- Daniels Jodie
- Darroch James
- Dasgupta Bhaskar
- Dasgupta Bhaskar
- Dasgupta Bhaskar
- Davies Charlotte
- Davies David
- Davies Rebecca
- Davies Ursula M.
- Dent Caroline
- Devanny Ian
- Dey Ida D.
- Dhanjal Mandish
- Dhillon Veena
- DiCicco Maria
- Dixey Josh
- Dixey Josh
- Doherty Teresa
- Donnelly Simon P.
- Driscoll Paul C.
- Duncan G.
- Duncan Rosie
- Dunn Sara
- Dures Emma
- Edgar Suzanne
- Edmonds Sally
- Edwards Christopher J.
- Edwards Christopher J.
- Edwards Steven W.
- Ellis Benjamin
- Ellis Corrinne
- Else Sara
- Emery Paul
- Ennis H.
- Estrach Cristina
- Estrach Cristina
- Evans Bronwen
- Evans Hayley G.
- Evans Laura
- Eyre Tracey
- Fang Hong
- Farrow Luke
- Fattah Zozik
- Ferrell William R.
- Field Max
- Finlay Ron
- Fisher Roman
- Fleming S.
- Fletcher Debbie
- Fluess Elisa
- Foggo Heather
- Fortune F.
- Fu Bo
- Gainsborough Nicola
- Galloway James
- Galloway James
- Garner Rozeena
- Garza-Garcia Acely
- Gathany Tim
- Gayed Mary
- Gayed Mary
- Georgia Ntani
- Giles Ian
- Giles Ian
- Giles Ian
- Giles Joanna L.
- Godfrey Keith M.
- Goff Iain
- Golor G.
- Goodson Nicola J.
- Goodson Nicola J.
- Goodson Nicola J.
- Gordon Caroline
- Gordon Caroline
- Gordon Caroline
- Gorman Claire L.
- Greenbank Cathi
- Griffiths Bridget
- Griffiths Bridget
- Gullick Nicola J.
- Gullick Nicola J.
- Gupta Monica
- Haddock Gail
- Haddock Gail
- Hakim Alan J.
- Halsey John
- Han Chenglong
- Hands Rebecca
- Harper Lorraine
- Harris Claire L.
- Harta N.
- Harvey Nicholas C.
- Hashmi Tahir M.
- Hassan Ahmed I.
- Hassell Andrew
- Hayes Fiona
- Hayes Fiona
- Heaney Jonathan
- Heathfield Sarah
- Heron Louise
- Herrick Ariane
- Hewlett Sarah
- Hewlett Sarah
- Hickling M.
- Horan Michael
- Hsia Elizabeth
- Hughes Michael
- Hui Michelle
- Hull Richard
- Hull Richard G.
- Humby Frances
- Humphreys Jennifer
- Hunter John
- Hunter John
- Husain Muhammad J.
- Hutchinson David
- Hyrich Kimme
- Hyrich Kimme
- Ibrahim Ibrahim
- Inskip Hazel M.
- Ioannou John
- Ioannou Yiannis
- Iqbal Itrat
- Irvine Elizabeth
- Isaacs John
- Isenberg David
- Isenberg David
- Isenberg David
- Isenberg David
- Isenberg David
- Ismajli Mediola
- Jani Meghna
- Jani Meghna
- Jayaraj David M.
- Jayne David
- Jenkins Jessica
- Jennens Hannah
- Jiang C. Q.
- John Elizabeth
- Johnson Phil
- Jones Gareth T.
- Jones Gareth T.
- Jones Simon A.
- Jullion A.
- Kallankara Sathish
- Kate I.
- Kay Lesley
- Keeley Philip
- Keidel Sarah
- Kelly Sara
- Kelly Stephen
- Kendall David
- Kenu Ernest
- Kessler Benedikt M.
- Khamashta Munther
- Khattak Fazlihakim
- Kiely Patrick D.
- Kindness Kathy
- Kollnberger Simon
- Kollnberger Simon
- Kollnberger Simon
- Kretsos K.
- Kumar Kanta
- Kumar Namita
- Kuvikova Inna
- Lam T. H.
- Lane Peter
- Lanyon Peter
- Lanyon Peter
- Lanyon Peter
- Lawton Sally
- Le Maitre Christine
- Le Maitre Christine L.
- Le Maitre Christine L.
- Ledingham Jo
- Lendrem Dennis
- Leung Jansen
- Lewis Cathryn M.
- Lim Ken
- Ling Stephanie
- Lip Stefanie
- Little Jayne
- Littlewood Alison
- Lockhart John
- Loke Yoon
- Lovell Karina
- Low Audrey
- Lunt Mark
- Lunt Mark
- Lutalo Pamela M.
- Macfarlane Gary J.
- Macfarlane Gary J.
- Macfarlane Gary J.
- Macfarlane Matthew V.
- MacGregor Alex
- MacGregor Alex
- MacGregor Alex
- Mackie Sarah L.
- Macphie Elizabeth
- Mahadik Younis
- Mahendranath K. M.
- Main Wong Way
- Malaviya Anshuman P.
- Marks Jonathan
- Marroquin Osiris
- Mason Justin
- Mc Laughlin Maeve
- McBeth John
- McBeth John
- McBurney H.
- McHugh Kirsty
- McHugh Kirsty
- McHugh Neil
- McHugh Neil
- McHugh Neil
- McInnes Iain
- McInnes Ian
- McKenna Frank
- McKeogh John
- Mckew Jennifer R.
- McLaren John
- McLoughlin Yokemei
- Mehta Puja
- Mehta Puja
- Meldrum Gillian
- Mercer Louise
- Middleton Jim
- Millar Auleen M.
- Misra Ramnath
- Mitchell Adam
- Mitchell Sheryl
- Mobasheri Ali
- Moots Robert J.
- Moots Robert J.
- Moots Robert J.
- Morgan Anne
- Morgan Matthew
- Morris Marianne
- Mugford Miranda
- Mulvey Matthew
- Mulvey Matthew R.
- Murfitt Lucy
- Murphy Helen
- Murray-Brown William
- Mérida Angeles Acosta
- Nayar Saba
- Nayar Saba
- Nazeer Moideen Abdul
- Nelson-Piercy Catherine
- Newman W.
- Ng Nora
- Ng Wan-Fai
- Nicholl Karl
- Nikiphorou Elena
- Nikiphorou Elena
- Nowell Mari A.
- O'Connor Mortimer B.
- O'Neill Terence
- Ogunbambi Olabambo
- Oldroyd Alexander G.
- Oomatia Amin
- Oreffo Richard O.
- Osei-Bordom Daniel-Clement
- Osgood Louise
- Ostor Andrew J.
- Owens Martina
- Palmer Helen
- Parker Ben
- Parker Ben
- Parker Ben
- Patel Dipti
- Patel Yusuf
- Patil Pravin
- Paudyal Priya
- Paul Morgan B.
- Pauling John D.
- Payeli Sravan
- Pearce Fiona
- Pease Colin T.
- Pease Colin T.
- Pendleton Neil
- Pericleous Charis
- Pericleous Charis
- Perry Liz
- Petri Michelle
- Phelan Mark J.
- Phillips Ceri J.
- Phillips E.
- Phillips Kate L. E.
- Picarelli G.
- Pierangeli Silvia
- Pierangeli Silvia S.
- Pilling Claire
- Pitzalis C.
- Pitzalis Costantino
- Pitzalis Costantino
- Pitzalis Costantino
- Plant Darren
- Plant Darren
- Platt Philip N.
- Plevin Robin
- Pope Denise
- Popham Maria
- Price Elizabeth
- Price Elizabeth
- Price-Forbes Alec
- Priori R.
- Pushpakom S.
- Rahman Anisur
- Rahman Anisur
- Rahman Anisur
- Rankin Elizabeth
- Rao Chandini
- Ray David W.
- Raza Karim
- Rees Frances
- Regan Marian
- Regan Marian
- Reid David M.
- Renner Christoph
- Reynolds John A.
- Reynolds Piero
- Rhys-Dillon Brian
- Ridley Anna
- Robertson Calum
- Robinson Frances
- Robinson Sandra
- Robinson Siân M.
- Rooke Royston
- Rooney Madeleine
- Roskell S.
- Roussou Thalia
- Roussou Thalia
- Rump-Goodrich Lisa
- Russell M.
- Rutherford Michelle
- Ryan Sarah
- Rysnik Oliwia J.
- Sanderson Tessa
- Sayer Avan A.
- Scott David L.
- Scott Ian C.
- Segeda Iuliia
- Selvan Shilpa
- Semenova Olga
- Sensky T.
- Seoudi N.
- Severn Andrew
- Shah Preeti
- Sharp Charlotte A.
- Shastri Nilabh
- Shaw Jackie
- Shaw Jacqueline
- Shaw S.
- Sheldon Jo
- Shevchuk Sergii
- Siebert Stefan
- Siebert Stefan
- Simpson John
- Sivakumar Rajappa
- Skeoch Sarah
- Sofat Nidhi
- Solymossy Csilla
- Spandley A.
- Spector Tim
- Spencer Jo
- Srikanth Asha
- Steer Sophia
- Stewart Kirsty
- Stockton Marie
- Stone Michael
- Strand V.
- Sutcliffe Nurhan
- Sutton Emily J.
- Swan Joan
- Symmons Deborah
- Symmons Deborah
- Symmons Deborah
- Symmons Deborah
- Symmons Deborah
- Taams Leonie S.
- Tahir Hasan
- Tan Shaun
- Tandon Neeta
- Tappuni T.
- Tarelli Edward
- Taylor P.
- Taylor Peter
- Taylor Peter
- Teh Lee-Suan
- Thapper Muryum
- Thapper Muryum
- Thomas Huw B.
- Thompson Helen
- Timoshanko J.
- Tugnet Nicola
- Tysoe Carolyn
- Vadivelu Saravanan
- Valesini G.
- Vartoukian S.
- Varughese Sneha
- Venning Michael
- Verstappen Suzanne M.
- Viatte Sebastien
- Vincent Tonia
- Walker David
- Walker-Bone Karen
- Walker-Bone Karen
- Walsh David A.
- Wang Edward
- Watson Kath
- Watson Kath D.
- Watts Richard
- Weaver Dan
- West Louise
- West Lucy
- Wilkinson Mark
- Williams Anwen S.
- Williams Anwen S.
- Williams Emma L.
- Williams Frances M.
- Williams Mark
- Williams Mark R.
- Wilson Anthony
- Wilson Gillian
- Wilson Jo
- Win Maw Win
- Woby Steve
- Wong-Baeza Isabel
- Wood Elizabeth F.
- Worthington J.
- Worthington Jane
- Wright Helen L.
- Wright Stephen A.
- Yates Max
- Yee Chee-Seng
- Young Adam
- Young Adam
- Young Stephen
- Young Stephen P.
- Zaki Awal
- Zeef Leo
- Zoma Asad
- Publication venue
- Publication date
- 02/08/2017
- Field of study
Background: Cardiovascular disease is a major comorbidity of rheumatoid arthritis (RA) and a leading cause of death. Chronic systemic inflammation involving tumour necrosis factor alpha (TNF) could contribute to endothelial activation and atherogenesis. A number of anti-TNF therapies are in current use for the treatment of RA, including certolizumab pegol (CZP), (Cimzia ®; UCB, Belgium). Anti-TNF therapy has been associated with reduced clinical cardiovascular disease risk and ameliorated vascular function in RA patients. However, the specific effects of TNF inhibitors on endothelial cell function are largely unknown. Our aim was to investigate the mechanisms underpinning CZP effects on TNF-activated human endothelial cells. Methods: Human aortic endothelial cells (HAoECs) were cultured in vitro and exposed to a) TNF alone, b) TNF plus CZP, or c) neither agent. Microarray analysis was used to examine the transcriptional profile of cells treated for 6 hrs and quantitative polymerase chain reaction (qPCR) analysed gene expression at 1, 3, 6 and 24 hrs. NF-κB localization and IκB degradation were investigated using immunocytochemistry, high content analysis and western blotting. Flow cytometry was conducted to detect microparticle release from HAoECs. Results: Transcriptional profiling revealed that while TNF alone had strong effects on endothelial gene expression, TNF and CZP in combination produced a global gene expression pattern similar to untreated control. The two most highly up-regulated genes in response to TNF treatment were adhesion molecules E-selectin and VCAM-1 (q 0.2 compared to control; p > 0.05 compared to TNF alone). The NF-κB pathway was confirmed as a downstream target of TNF-induced HAoEC activation, via nuclear translocation of NF-κB and degradation of IκB, effects which were abolished by treatment with CZP. In addition, flow cytometry detected an increased production of endothelial microparticles in TNF-activated HAoECs, which was prevented by treatment with CZP. Conclusions: We have found at a cellular level that a clinically available TNF inhibitor, CZP reduces the expression of adhesion molecule expression, and prevents TNF-induced activation of the NF-κB pathway. Furthermore, CZP prevents the production of microparticles by activated endothelial cells. This could be central to the prevention of inflammatory environments underlying these conditions and measurement of microparticles has potential as a novel prognostic marker for future cardiovascular events in this patient group. Disclosure statement: Y.A. received a research grant from UCB. I.B. received a research grant from UCB. S.H. received a research grant from UCB. All other authors have declared no conflicts of interes
The interspecific growth–mortality trade-off is not a general framework for tropical forest community structure
- Author
- Ashton Peter S.
- Bunyavejchewin Sarayudh
- Chang-Yang Chia-Hao
- Condit Richard S.
- Davies Stuart J.
- Detto Matteo
- Ediriweera Sisira
- Ewango Corneille E.N.
- Fletcher Christine
- Foster Robin B.
- Gunatilleke C.V. Savi
- Gunatilleke I.A.U. Nimal
- Hart Terese
- Hsieh Chang-Fu
- Hubbell Stephen P.
- Itoh Akira
- Kassim Abdul Rahman
- Ledder Glenn
- Leong Yao Tze
- Lin Yi Ching
- Makana Jean-Remy
- McMahon Sean M.
- Mohamad Mohizah Bt.
- Ong Perry
- Russo Sabrina E.
- Sugiyama Anna
- Sun I-Fang
- Tan Sylvester
- Thompson Jill
- Wright S. Joseph
- Yamakura Takuo
- Yap Sandra L.
- Zimmerman Jess K.
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2021
- Field of study
Resource allocation within trees is a zero-sum game. Unavoidable trade-offs dictate that allocation to growth-promoting functions curtails other functions, generating a gradient of investment in growth versus survival along which tree species align, known as the interspecific growth–mortality trade-off. This paradigm is widely accepted but not well established. Using demographic data for 1,111 tree species across ten tropical forests, we tested the generality of the growth–mortality trade-off and evaluated its underlying drivers using two species-specific parameters describing resource allocation strategies: tolerance of resource limitation and responsiveness of allocation to resource access. Globally, a canonical growth–mortality trade-off emerged, but the trade-off was strongly observed only in less disturbance-prone forests, which contained diverse resource allocation strategies. Only half of disturbance-prone forests, which lacked tolerant species, exhibited the trade-off. Supported by a theoretical model, our findings raise questions about whether the growth–mortality trade-off is a universally applicable organizing framework for understanding tropical forest community structure
Search for dark matter produced in association with bottom or top quarks in √s = 13 TeV pp collisions with the ATLAS detector
- Author
- Aaboud Morad
- Aad Georges
- Abbott Brad
- Abdinov Ovsat
- Abeloos Baptiste
- Abidi Syed
- AbouZeid Ossama
- Abraham Nicola
- Abramowicz Halina
- Abreu Henso
- Abreu Ricardo
- Abulaiti Yiming
- Acharya Bobby
- Adachi Shunsuke
- Adamczyk Leszek
- Adelman Jahred
- Adersberger Michael
- Adye Tim
- Affolder Tony
- Afik Yoav
- Agatonovic-Jovin Tatjana
- Agheorghiesei Catalin
- Aguilar-Saavedra Juan
- Ahlen Steven
- Ahmadov Faig
- Aielli Giulio
- Akatsuka Shunichi
- Akerstedt Henrik
- Akilli Ece
- Akimov Andrei
- Alberghi Gian
- Albert Justin
- Albicocco Pietro
- Alconada Verzini Maria
- Alderweireldt Sara
- Aleksa Martin
- Aleksandrov Igor
- Alexa Calin
- Alexander Gideon
- Alexopoulos Theodoros
- Alhroob Muhammad
- Ali Babar
- Aliev Malik
- Alimonti Gianluca
- Alison John
- Alkire Steven
- Allbrooke Benedict
- Allen Benjamin
- Allport Phillip
- Aloisio Alberto
- Alonso Alejandro
- Alonso Francisco
- Alpigiani Cristiano
- Alshehri Azzah
- Alstaty Mahmoud
- Alvarez Gonzalez Barbara
- Alviggi Mariagrazia
- Amadio Brian
- Amaral Coutinho Yara
- Amelung Christoph
- Amidei Dante
- Amor Dos Santos Susana
- Amoroso Simone
- Anastopoulos Christos
- Ancu Lucian
- Andari Nansi
- Andeen Timothy
- Anders Christoph
- Anders John
- Anderson Kelby
- Andreazza Attilio
- Andrei George
- Angelidakis Stylianos
- Angelozzi Ivan
- Angerami Aaron
- Anisenkov Alexey
- Anjos Nuno
- Annovi Alberto
- Antel Claire
- Antonelli Mario
- Antonov Alexey
- Antrim Daniel
- Anulli Fabio
- Aoki Masato
- Aperio Bella Ludovica
- Arabidze Giorgi
- Arai Yasuo
- Araque Juan
- Araujo Ferraz Victor
- Arce Ayana
- Ardell Rose
- Arduh Francisco
- Arguin Jean-Francois
- Argyropoulos Spyridon
- Arik Metin
- Armbruster Aaron
- Armitage Lewis
- Arnaez Olivier
- Arnold Hannah
- Arratia Miguel
- Arslan Ozan
- Artamonov Andrei
- Artoni Giacomo
- Artz Sebastian
- Asai Shoji
- Asbah Nedaa
- Ashkenazi Adi
- Asquith Lily
- Assamagan Ketevi
- Astalos Robert
- Atkinson Markus
- Atlay Naim
- Augsten Kamil
- Avolio Giuseppe
- Axen Bradley
- Ayoub Mohamad
- Azuelos Georges
- Baas Alessandra
- Baca Matthew
- Bachacou Henri
- Bachas Konstantinos
- Backes Moritz
- Bagnaia Paolo
- Bahmani Marzieh
- Bahrasemani Sina
- Baines John
- Bajic Milena
- Baker Oliver
- Bakker Pepijn
- Baldin Evgenii
- Balek Petr
- Balli Fabrice
- Balunas William
- Banas Elzbieta
- Bandyopadhyay Anjishnu
- Banerjee Swagato
- Bannoura Arwa
- Barak Liron
- Barberio Elisabetta
- Barberis Dario
- Barbero Marlon
- Barillari Teresa
- Barisits Martin-Stefan
- Barkeloo Jason
- Barklow Timothy
- Barlow Nick
- Barnes Sarah
- Barnett Bruce
- Barnett Michael
- Barnovska-Blenessy Zuzana
- Baroncelli Antonio
- Barone Gaetano
- Barr Alan
- Barranco Navarro Laura
- Barreiro Guimarães da Costa João
- Barreiro Fernando
- Barros Vale Maria
- Bartoldus Rainer
- Barton Adam
- Bartos Pavol
- Basalaev Artem
- Bassalat Ahmed
- Bates Richard
- Batista Santiago
- Batley Richard
- Battaglia Marco
- Bauce Matteo
- Bauer Florian
- Bawa Harinder
- Beacham James
- Beattie Michael
- Beau Tristan
- Beauchemin Pierre-Hugues
- Bechtle Philip
- Beck Hans~Peter
- Beck Helge
- Becker Kathrin
- Becker Maurice
- Becot Cyril
- Beddall Andrew
- Beddall Ayda
- Bednyakov Vadim
- Bedognetti Matteo
- Bee Christopher
- Beermann Thomas
- Begalli Marcia
- Begel Michael
- Behr Janna
- Bell Andrew
- Bella Gideon
- Bellagamba Lorenzo
- Bellerive Alain
- Bellomo Massimiliano
- Belotskiy Konstantin
- Beltramello Olga
- Belyaev Nikita
- Benary Odette
- Benchekroun Driss
- Bender Michael
- Benekos Nektarios
- Benhammou Yan
- Benhar Noccioli Eleonora
- Benitez Jose
- Benjamin Douglas
- Benoit Mathieu
- Bensinger James
- Bentvelsen Stan
- Beresford Lydia
- Beretta Matteo
- Berge David
- Bergeaas Kuutmann Elin
- Berger Nicolas
- Bergsten Laura
- Beringer Jürg
- Berlendis Simon
- Bernard Nathan
- Bernardi Gregorio
- Bernius Catrin
- Bernlochner Florian
- Berry Tracey
- Berta Peter
- Bertella Claudia
- Bertoli Gabriele
- Bertram Iain
- Bertsche Carolyn
- Besjes Geert-Jan
- Bessidskaia Bylund Olga
- Bessner Martin
- Besson Nathalie
- Bethani Agni
- Bethke Siegfried
- Betti Alessandra
- Bevan Adrian
- Beyer Julien-christopher
- Bianchi Riccardo-Maria
- Biebel Otmar
- Biedermann Dustin
- Bielski Rafal
- Bierwagen Katharina
- Biesuz Nicolo
- Biglietti Michela
- Billoud Thomas
- Bilokon Halina
- Bindi Marcello
- Bingul Ahmet
- Bini Cesare
- Biondi Silvia
- Bisanz Tobias
- Bittrich Carsten
- Bjergaard David
- Black James
- Black Kevin
- Blair Robert
- Blazek Tomas
- Bloch Ingo
- Blocker Craig
- Blue Andrew
- Blumenschein Ulrike
- Blunier Sylvain
- Bobbink Gerjan
- Bobrovnikov Victor
- Bocchetta Simona
- Bocci Andrea
- Bock Christopher
- Boehler Michael
- Boerner Daniela
- Bogavac Danijela
- Bogdanchikov Alexander
- Bohm Christian
- Boisvert Veronique
- Bokan Petar
- Bold Tomasz
- Boldyrev Alexey
- Bolz Arthur
- Bomben Marco
- Bona Marcella
- Boonekamp Maarten
- Borisov Anatoly
- Borissov Guennadi
- Bortfeldt Jonathan
- Bortoletto Daniela
- Bortolotto Valerio
- Boscherini Davide
- Bosman Martine
- Bossio Sola Jonathan
- Boudreau Joseph
- Bouhova-Thacker Evelina
- Boumediene Djamel
- Bourdarios Claire
- Boutle Sarah
- Boveia Antonio
- Boyd James
- Boyko Igor
- Bozson Adam
- Bracinik Juraj
- Brandt Andrew
- Brandt Gerhard
- Brandt Oleg
- Braren Frued
- Bratzler Uwe
- Brau Benjamin
- Brau James
- Breaden Madden William
- Brendlinger Kurt
- Brennan Amelia
- Brenner Lydia
- Brenner Richard
- Bressler Shikma
- Briglin Daniel
- Bristow Timothy
- Britton Dave
- Britzger Daniel
- Brochu Frederic
- Brock Ian
- Brock Raymond
- Brooijmans Gustaaf
- Brooks Timothy
- Brooks William
- Brosamer Jacquelyn
- Brost Elizabeth
- Broughton James
- Bruckman de Renstrom Pawel
- Bruncko Dusan
- Bruni Alessia
- Bruni Graziano
- Bruni Lucrezia
- Bruno Salvatore
- Brunt Benjamin
- Bruschi Marco
- Bruscino Nello
- Bryant Patrick
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- C-Q Changqiao
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- Da Cunha Sargedas De Sousa Mario
- Da Via Cinzia
- Dabrowski Wladyslaw
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- de Asmundis Riccardo
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- De Castro Stefano
- De Cecco Sandro
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- De la Torre Hector
- De Lorenzi Francesco
- De Maria Antonio
- De Pedis Daniele
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- De Santo Antonella
- De Vasconcelos Corga Kevin
- De Vivie De Regie Jean-Baptiste
- De Kaushik
- Debbe Ramiro
- Debenedetti Chiara
- Dedovich Dmitri
- Dehghanian Nooshin
- Deigaard Ingrid
- Del Gaudio Michela
- Del Peso Jose
- Delgove David
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- Dell'Acqua Andrea
- Dell'Asta Lidia
- Dell'Orso Mauro
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- della Volpe Domenico
- Delmastro Marco
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- Delsart Pierre-Antoine
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- Demichev Mikhail
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- Derendarz Dominik
- Derkaoui Jamal
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- Desch Klaus
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- Di Bello Francesco
- Di Ciaccio Anna
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- Di Clemente William
- Di Donato Camilla
- Di Girolamo Alessandro
- Di Girolamo Beniamino
- Di Micco Biagio
- Di Nardo Roberto
- Di Petrillo Karri
- Di Simone Andrea
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- Dolezal Zdenek
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- Dova Maria-Teresa
- Doyle Tony
- Drechsler Eric
- Dris Manolis
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- Dudder Andreas
- Duffield Emily
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- Dumancic Mirta
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- Duschinger Dirk
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- Dyndal Mateusz
- Dziedzic Bartosz
- Díez Cornell Sergio
- Dührssen Michael
- Düren Michael
- Eckardt Christoph
- Ecker Katharina
- Edgar Ryan
- Eifert Till
- Eigen Gerald
- Einsweiler Kevin
- Ekelof Tord
- El Kacimi Mohamed
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- Ellajosyula Venugopal
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- Elles Sabine
- Ellinghaus Frank
- Elliot Alison
- Ellis Nicolas
- Elmsheuser Johannes
- Elsing Markus
- Emeliyanov Dmitry
- Enari Yuji
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- Etienvre Anne-Isabelle
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- Ezhilov Alexey
- Ezzi Mohammed
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- Faucci Giannelli Michele
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- Fawcett William
- Fayard Louis
- Fedin Oleg
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- Feigl Simon
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- Fenyuk Alexander
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- Fiedler Frank
- Filipuzzi Marco
- Filipčič Andrej
- Filthaut Frank
- Fincke-Keeler Margret
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- Fiolhais Miguel
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- Flowerdew Michael
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- Francavilla Paolo
- Franchini Matteo
- Franchino Silvia
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- Franklin Melissa
- Frate Meghan
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- Freeborn David
- Fressard-Batraneanu Silvia
- Freund Benjamin
- Froidevaux Daniel
- Frost James
- Fukunaga Chikara
- Fusayasu Takahiro
- Fuster Juan
- Förster Fabian
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- Gabrielli Alessandro
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- Gach Grzegorz
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- Gadomski Szymon
- Gagliardi Guido
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- Gallus Petr
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- Gan Kk
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- Garay Walls Francisca
- Garcia-Sciveres Maurice
- García Navarro José
- García Pascual Juan
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- Gascon Bravo Alberto
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- Gay Colin
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- Gemme Claudia
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- Gibson Stephen
- Gignac Matthew
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- Gillberg Dag
- Gilles Geoffrey
- Gingrich Douglas
- Giordani MarioPaolo
- Giorgi Filippo
- Giraud Pierre-Francois
- Giromini Paolo
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- Gladilin Leonid
- Glasman Claudia
- Glatzer Julian
- Glaysher Paul
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- Goblirsch-Kolb Maximilian
- Godlewski Jan
- Goldfarb Steven
- Golling Tobias
- Golubkov Dmitry
- Gomes Agostinho
- Goncalves Gama Rafael
- Goncalves Pinto Firmino Da Costa Joao
- Gonella Giulia
- Gonella Laura
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- Gonnella Francesco
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- Gonzalez-Sevilla Sergio
- González de la Hoz Santiago
- Gonçalo Ricardo
- Goossens Luc
- Gorbounov Petr
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- Gorini Benedetto
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- Gorišek Andrej
- Goshaw Alfred
- Gostkin Mikhail
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- Goudet Christophe
- Goujdami Driss
- Goussiou Anna
- Govender Nicolin
- Gozani Eitan
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- Gradin Per
- Gramling Johanna
- Gramstad Eirik
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- Gratchev Vadim
- Gravila Paul
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- Gray Heather
- Greenwood Zeno
- Grefe Christian
- Gregersen Kristian
- Gregor Ingrid-Maria
- Grenier Philippe
- Grevtsov Kirill
- Griffiths Justin
- Grillo Alexander
- Grimm Kathryn
- Grinstein Sebastian
- Gris Philippe
- Grivaz Jean-Francois
- Groh Sabrina
- Gross Eilam
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- Grout Zara
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- Guan Liang
- Guan Wen
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- Guest Daniel
- Gueta Orel
- Gui Bin
- Guido Elisa
- Guillemin Thibault
- Guindon Stefan
- Gul Umar
- Gumpert Christian
- Guo Jun
- Guo Wen
- Guo Yicheng
- Gupta Ruchi
- Gurbuz Saime
- Gustavino Giuliano
- Gutelman Benjamin
- Gutierrez Ortiz Nicolas
- Gutierrez Phillip
- Gutschow Christian
- Guyot Claude
- Guzik Marcin
- Gwenlan Claire
- Gwilliam Carl
- Gössling Claus
- Haas Andy
- Haber Carl
- Hadavand Haleh
- Haddad Nacim
- Hadef Asma
- Hageböck Stephan
- Hagihara Mutsuto
- Hakobyan Hrachya
- Haleem Mahsana
- Haley Joseph
- Halladjian Garabed
- Hallewell Gregory
- Hamacher Klaus
- Hamal Petr
- Hamano Kenji
- Hamilton Andrew
- Hamity Guillermo
- Hamnett Phillip
- Han Liang
- Han Shuo
- Hanagaki Kazunori
- Hanawa Keita
- Hance Michael
- Handl David
- Haney Bijan
- Hanke Paul
- Hansen Jorn
- Hansen Jørgen
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- Hara Kazuhiko
- Hard Andrew
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- Hariri Faten
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- Hartmann Nikolai
- Hasegawa Yoji
- Hasib Ahmed
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- Haug Sigve
- Hauser Reiner
- Hauswald Lorenz
- Havener Laura
- Havranek Miroslav
- Hawkes Christopher
- Hawkings Richard
- Hayakawa Daiki
- Hayden Daniel
- Hays Chris
- Hays Jonathan
- Hayward Helen
- Haywood Stephen
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- Heidegger Kim
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- Heinemann Beate
- Heinrich Jochen
- Heinrich Lukas
- Heinz Christian
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- Helary Louis
- Held Alexander
- Hellman Sten
- Helsens Clement
- Henderson Robert
- Heng Yang
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- Henriques Correia Ana
- Henrot-Versille Sophie
- Herbert Geoffrey
- Herde Hannah
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- Herr Holger
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- Hertenberger Ralf
- Hervas Luis
- Herwig Theodor
- Hesketh Gavin
- Hessey Nigel
- Hetherly Jeffrey
- Higashino Satoshi
- Higón-Rodriguez Emilio
- Hildebrand Kevin
- Hill Ewan
- Hill John
- Hiller Karl
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- Hinchliffe Ian
- Hirose Minoru
- Hirschbuehl Dominic
- Hiti Bojan
- Hladik Ondrej
- Hlaluku Dingane
- Hoad Xanthe
- Hobbs John
- Hod Noam
- Hodgkinson Mark
- Hodgson Paul
- Hoecker Andreas
- Hoeferkamp Martin
- Hoenig Friedrich
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- Holzbock Michael
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- Honda Shunsuke
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- Hong Tae
- Hooberman Benjamin
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- Horii Yasuyuki
- Horton Arthur
- Hostachy Jean-Yves
- Hostiuc Alexandru
- Hou Suen
- Hoummada Abdeslam
- Howarth James
- Hoya Joaquin
- Hrabovsky Miroslav
- Hrdinka Julia
- Hristova Ivana
- Hrivnac Julius
- Hryn'ova Tetiana
- Hrynevich Aliaksei
- Hsu Pai-hsien
- Hsu Shih-Chieh
- Hu Qipeng
- Hu Shuyang
- Huang Yanping
- Hubacek Zdenek
- Hubaut Fabrice
- Huegging Fabian
- Huffman Todd
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- Huhtinen Mika
- HUNTER Robert
- Huo Peng
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- Huston Joey
- Huth John
- Hyneman Rachel
- Iacobucci Giuseppe
- Iakovidis Georgios
- Ibragimov Iskander
- Iconomidou-Fayard Lydia
- Idrissi Zineb
- Iengo Paolo
- Igonkina Olga
- Iizawa Tomoya
- Ikegami Yoichi
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- Ito Fumiaki
- Iturbe Ponce Julia
- Iuppa Roberto
- Iwasaki Hiroyuki
- Izen Joseph
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- Jakobs Karl
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- Janus Piotr
- Jarlskog Göran
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- Jinnouchi Osamu
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- Johansson Per
- Johns Kenneth
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- Jones Samuel
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- Jones Tim
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- Kagan Michael
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- Kalderon Charles
- Kaluza Adam
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- Kamenshchikov Andrey
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- Kaplan Benjamin
- Kaplan Laser
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- Kartvelishvili Vakhtang
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- Kass Richard
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- Kataoka Yousuke
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- Katzy Judith
- Kawade Kentaro
- Kawagoe Kiyotomo
- Kawamoto Tatsuo
- Kawamura Gen
- Kay Ellis
- Kazanin Vassili
- Keeler Richard
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- Kendrick James
- Keoshkerian Houry
- Kepka Oldrich
- Kersten Susanne
- Kerševan Borut
- Keyes Robert
- Khader Mazin
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- Khanov Alexander
- Kharlamov Alexey
- Kharlamova Tatyana
- Khodinov Alexander
- Khoo Teng
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- Khubua Jemal
- Kido Shogo
- Kilby Callum
- Kim Hee
- Kim Shinhong
- Kim Young-Kee
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- Kind Oliver
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- Kirchmeier David
- Kirk Julie
- Kiryunin Andrey
- Kishimoto Tomoe
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- Kladiva Eduard
- Klapdor-Kleingrothaus Thorwald
- Klein Matthew
- Klein Max
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- Klingl Tobias
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- Kluth Stefan
- Kneringer Emmerich
- Knoops Edith
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- Kobayashi Aine
- Kobayashi Dai
- Kobayashi Tomio
- Kobel Michael
- Kocian Martin
- Kodys Peter
- Koffas Thomas
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- Kolb Mathis
- Koletsou Iro
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- Korol Aleksandr
- Korolkov Ilya
- Korolkova Elena
- Kortner Oliver
- Kortner Sandra
- Kosek Tomas
- Kostyukhin Vadim
- Kotwal Ashutosh
- Koulouris Aimilianos
- Kourkoumeli-Charalampidi Athina
- Kourkoumelis Christine
- Kourlitis Evangelos
- Kouskoura Vasiliki
- Kowalewska Anna
- Kowalewski Robert
- Kowalski Tadeusz
- Kozakai Chihiro
- Kozanecki Witold
- Kozhin Anatoly
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- Krauss Dominik
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- Kreutzfeldt Kristof
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- Kroha Hubert
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- Kruchonak Uladzimir
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- Kruse Mark
- Krüger Hans
- Kubota Takashi
- Kucuk Hilal
- Kuday Sinan
- Kuechler Jan
- Kuehn Susanne
- Kugel Andreas
- Kuger Fabian
- Kuhl Thorsten
- Kukhtin Victor
- Kukla Romain
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- Kunigo Takuto
- Kupco Alexander
- Kupfer Tobias
- Kuprash Oleg
- Kurashige Hisaya
- Kurchaninov Leonid
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- Takasugi Eric
- Takeda Kosuke
- Takeshita Tohru
- Takubo Yosuke
- Talby Mossadek
- Talyshev Alexey
- Tanaka Junichi
- Tanaka Masahiro
- Tanaka Reisaburo
- Tanaka Shuji
- Tanioka Ryo
- Tannenwald Benjamin
- Tapia Araya Sebastian
- Tapprogge Stefan
- Tarem Shlomit
- Tartarelli Giuseppe
- Tas Petr
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- Tashiro Takuya
- Tassi Enrico
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- Tayalati Yahya
- Taylor Aaron
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- Temple Darren
- Ten Kate Herman
- Teng Ping-Kun
- Teoh Jia
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- Terada Susumu
- Terashi Koji
- Terron Juan
- Terzo Stefano
- Testa Marianna
- Teuscher Richard
- Thais Savannah
- Theveneaux-Pelzer Timothée
- Thiele Fabian
- Thomas Juergen
- Thomas-Wilsker Joshuha
- Thompson Paul
- Thompson Stan
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- Thomson Evelyn
- Tian Yun
- Tibbetts Mark
- Ticse Torres Royer
- Tikhomirov Vladimir
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- Timoshenko Sergey
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- Todome Kazuki
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- Trofymov Artur
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- Yamanaka Takashi
- Yamane Fumiya
- Yamatani Masahiro
- Yamazaki Tomohiro
- Yamazaki Yuji
- Yan Zhen
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- Yang Hongtao
- Yang Yi
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- Yao Weiming
- Yap Yee
- Yasu Yoshiji
- Yatsenko Elena
- Yau Wong Kaven
- Ye Jingbo
- Ye Shuwei
- Yeletskikh Ivan
- Yigitbasi Efe
- Yildirim Eda
- Yorita Kohei
- Yoshihara Keisuke
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- Yu Jaehoon
- Yu Jie
- Yuen Stephanie
- Yusuff Imran
- Zabinski Bartlomiej
- Zacharis Georgios
- Zaidan Remi
- Zaitsev Alexander
- Zakharchuk Nataliia
- Zalieckas Justas
- Zaman Aungshuman
- Zambito Stefano
- Zanzi Daniele
- Zeitnitz Christian
- Zemaityte Gabija
- Zemla Andrzej
- Zeng Jian
- Zeng Qi
- Zenin Oleg
- Zerwas Dirk
- Zhang Dengfeng
- Zhang Dongliang
- Zhang Fangzhou
- Zhang Guangyi
- Zhang Huijun
- Zhang Jinlong
- Zhang Lei
- Zhang Liqing
- Zhang Matt
- Zhang Peng
- Zhang Rui
- Zhang Ruiqi
- Zhang Xueyao
- Zhang Yu
- Zhang Zhiqing
- Zhao Xiandong
- Zhao Yongke
- Zhao Zhengguo
- Zhemchugov Alexey
- Zhou Bing
- Zhou Chen
- Zhou Li
- Zhou Maosen
- Zhou Mingliang
- Zhou Ning
- Zhou You
- Zhu Cheng
- Zhu Hongbo
- Zhu Junjie
- Zhu Yingchun
- Zhuang Xuai
- Zhukov Konstantin
- Zibell Andre
- Zieminska Daria
- Zimine Nikolai
- Zimmermann Christoph
- Zimmermann Stephanie
- Zinonos Zinonas
- Zinser Markus
- Ziolkowski Michael
- Zobernig Georg
- Zoccoli Antonio
- Zou Rui
- zur Nedden Martin
- Zwalinski Lukasz
- Åkesson Torsten
- Šfiligoj Tina
- Ženiš Tibor
- Živković Lidija
- Άlvarez Piqueras Damián
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2017
- Field of study
A search for weakly interacting massive particle dark matter produced in association with bottom or top quarks is presented. Final states containing third-generation quarks and miss- ing transverse momentum are considered. The analysis uses 36.1 fb−1 of proton–proton collision data recorded by the ATLAS experiment at √s = 13 TeV in 2015 and 2016. No significant excess of events above the estimated backgrounds is observed. The results are in- terpreted in the framework of simplified models of spin-0 dark-matter mediators. For colour- neutral spin-0 mediators produced in association with top quarks and decaying into a pair of dark-matter particles, mediator masses below 50 GeV are excluded assuming a dark-matter candidate mass of 1 GeV and unitary couplings. For scalar and pseudoscalar mediators produced in association with bottom quarks, the search sets limits on the production cross- section of 300 times the predicted rate for mediators with masses between 10 and 50 GeV and assuming a dark-matter mass of 1 GeV and unitary coupling. Constraints on colour- charged scalar simplified models are also presented. Assuming a dark-matter particle mass of 35 GeV, mediator particles with mass below 1.1 TeV are excluded for couplings yielding a dark-matter relic density consistent with measurements
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