98 research outputs found
Polymorphism in genes of the progesterone receptor (PROGINS) in women with breast cancer: a case-control study
PURPOSE: to analyze the correlation between PROGINS polymorphism and breast cancer. METHODS: a case-control study was carried out from April to October 2004. The genotypes of 50 women with breast cancer and 49 healthy women were analyzed. The 306-base pair Alu insertion polymorphism in the G intron of progesterone receptor gene was detected by polymerase chain reaction and analyzed on 2% agarose gel stained with ethidium bromide. The control and experimental groups were compared regarding genotypes using the statistical Epi-Info 6.0 program and for frequencies the exact Fisher test or chi2 test were used. p value smaller p than 5% was considered to be significant. RESULTS: in relation to PROGINS we found in the studied population a prevalence of 62 (62.6%) wild homozygous, 35 (35.3%) heterozygous individuals and two (2.1%) cases with the presence of the mutation. Regarding PROGINS polymorphism, significance was not evidenced when cases and controls were compared, as related to homozygosis (62 vs 65.3%), heterozygosis (36 vs 34,6%) or the mutation (2.0 vs 2.1%), with p=0.920 (OR=1.01), 0.891 (OR=1.06), and 0.988 (OR=1.10), respectively. CONCLUSIONS: the results show that single-gene PROGINS polymorphism does not confer a substantial risk of breast cancer to its carriers.OBJETIVOS: analisar a correlação entre o polimorfismo PROGINS e o câncer de mama. MÉTODOS: estudo caso-controle desenvolvido entre abril e outubro de 2004 com o pareamento de 50 mulheres com diagnóstico histopatológico de carcinoma de mama e 49 mulheres saudáveis. A inserção Alu de 306 pares de base no intron G do gene do receptor da progesterona denominada PROGINS foi detectada por meio de reação em cadeia da polimerase e analisada em gel de agarose 2% corado com brometo de etídio. Os grupos controle e experimental foram comparados, por meio de programa estatístico Epi-Info 6.0, quanto aos genótipos e às freqüências alélicas, utilizando-se o teste do chi2. RESULTADOS: em relação ao PROGINS encontramos uma prevalência na população estudada de 62 (62,6%) indivíduos homozigotos selvagens, 35 (35,3%) de heterozigotos e dois (2,1%) casos com a presença da mutação. Não foi evidenciada diferença significante em relação ao polimorfismo PROGINS, quando comparados os casos e controles, seja com relação à homozigose (62 vs 65,3%), heterozigose (36 vs 34,6%) ou à presença de mutação (2,0 vs 2,1%), com p de 0,920 (OR=1,01), 0,891 (OR=1,06) e 0,988 (OR=1,10), respectivamente. CONCLUSÕES: os resultados mostraram que o polimorfismo PROGINS não conferiu risco substancial de câncer de mama em seus portadores.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Universidade Federal do Ceará Faculdade de MedicinaUniversidade Federal de São Paulo (UNIFESP) Departamento de Ginecologia Laboratório de Ginecologia MolecularUniversidade Federal de São Paulo (UNIFESP) Departamento de GinecologiaHospital do Servidor Público Estadual Laboratório de ImunologiaHospital do Servidor Público Estadual Seção de MastologiaHospital do Servidor Público Estadual Serviço de Ginecologia e ObstetríciaUNIFESP, Depto. de Ginecologia Laboratório de Ginecologia MolecularUNIFESP, Depto. de GinecologiaSciEL
Implementation and performances of the IPbus protocol for the JUNO Large-PMT readout electronics
The Jiangmen Underground Neutrino Observatory (JUNO) is a large neutrino
detector currently under construction in China. Thanks to the tight
requirements on its optical and radio-purity properties, it will be able to
perform leading measurements detecting terrestrial and astrophysical neutrinos
in a wide energy range from tens of keV to hundreds of MeV. A key requirement
for the success of the experiment is an unprecedented 3% energy resolution,
guaranteed by its large active mass (20 kton) and the use of more than 20,000
20-inch photo-multiplier tubes (PMTs) acquired by high-speed, high-resolution
sampling electronics located very close to the PMTs. As the Front-End and
Read-Out electronics is expected to continuously run underwater for 30 years, a
reliable readout acquisition system capable of handling the timestamped data
stream coming from the Large-PMTs and permitting to simultaneously monitor and
operate remotely the inaccessible electronics had to be developed. In this
contribution, the firmware and hardware implementation of the IPbus based
readout protocol will be presented, together with the performances measured on
final modules during the mass production of the electronics
Mass testing of the JUNO experiment 20-inch PMTs readout electronics
The Jiangmen Underground Neutrino Observatory (JUNO) is a multi-purpose,
large size, liquid scintillator experiment under construction in China. JUNO
will perform leading measurements detecting neutrinos from different sources
(reactor, terrestrial and astrophysical neutrinos) covering a wide energy range
(from 200 keV to several GeV). This paper focuses on the design and development
of a test protocol for the 20-inch PMT underwater readout electronics,
performed in parallel to the mass production line. In a time period of about
ten months, a total number of 6950 electronic boards were tested with an
acceptance yield of 99.1%
Validation and integration tests of the JUNO 20-inch PMTs readout electronics
The Jiangmen Underground Neutrino Observatory (JUNO) is a large neutrino
detector currently under construction in China. JUNO will be able to study the
neutrino mass ordering and to perform leading measurements detecting
terrestrial and astrophysical neutrinos in a wide energy range, spanning from
200 keV to several GeV. Given the ambitious physics goals of JUNO, the
electronic system has to meet specific tight requirements, and a thorough
characterization is required. The present paper describes the tests performed
on the readout modules to measure their performances.Comment: 20 pages, 13 figure
Understanding Gender Inequality in Poverty and Social Exclusion through a Psychological Lens:Scarcities, Stereotypes and Suggestions
Real-time Monitoring for the Next Core-Collapse Supernova in JUNO
Core-collapse supernova (CCSN) is one of the most energetic astrophysical
events in the Universe. The early and prompt detection of neutrinos before
(pre-SN) and during the SN burst is a unique opportunity to realize the
multi-messenger observation of the CCSN events. In this work, we describe the
monitoring concept and present the sensitivity of the system to the pre-SN and
SN neutrinos at the Jiangmen Underground Neutrino Observatory (JUNO), which is
a 20 kton liquid scintillator detector under construction in South China. The
real-time monitoring system is designed with both the prompt monitors on the
electronic board and online monitors at the data acquisition stage, in order to
ensure both the alert speed and alert coverage of progenitor stars. By assuming
a false alert rate of 1 per year, this monitoring system can be sensitive to
the pre-SN neutrinos up to the distance of about 1.6 (0.9) kpc and SN neutrinos
up to about 370 (360) kpc for a progenitor mass of 30 for the case
of normal (inverted) mass ordering. The pointing ability of the CCSN is
evaluated by using the accumulated event anisotropy of the inverse beta decay
interactions from pre-SN or SN neutrinos, which, along with the early alert,
can play important roles for the followup multi-messenger observations of the
next Galactic or nearby extragalactic CCSN.Comment: 24 pages, 9 figure
The imaging for the the successful bio-communication: ORBS Brand
Producing accessible communication based on scientific research usually involves a great deal
of effort in translating complex concepts into a non professional oriented information, but it is
only through widely accessible data that knowledge dissemination have stronger
repercussions in society.
In concordance to this statement, the CNR IAMC and the “Accademia di Belle Arti di Palermo”
collaborated in the work frame of the "Information, dissemination and communication system
of the Biodiversity Observatory of Sicily” project, a synergistic interaction between science
and art.
The researchers held biodiversity seminars to the Academy students, involving 19
professorships, aiming to increase the knowledge degree and awareness on the biodiversity,
thus stimulating their creativity.
One of the main activities carried out during this collaboration was the conceptualization and
designing of the Biodiversity Observatory brand, with the representation of biodiversity as the
main briefing.
The winning proposal was chosen between 13 projects by popular vote, with the participation
of more than 800 students and CNR researchers.
The branding is a representation of the environment with the use of different animal
silhouettes as a symbol of biodiversity. The elements are arranged on a spiral grid suggesting
movement, a current that raises deep, nutrient-rich waters to the ocean surface.
Extremely evocative and appealing, the logotype has become an integral part of the
Observatory's identity, and it's been profusely applied over the years on communication and
divulgative materials, website, exhibitions, and memorabilia.
Involving such a large number of students and their social groups (family, friends, and
etcetera) meant giving the citizens a leading role in an important activity.
Participation of the public in the creation of the graphic identity of a key structure in their
territory resulted in a dramatic increase of sensitization on the biodiversity and environmental
cause and participation in divulgation activities in the following years
La Scienza e l'immaginario
L’attività di divulgazione della cultura scientifica ha un ruolo fondamentale sulla società, sia in termini di applicazioni innovative che di pianificazione dell’ambiente.
I ricercatori dell’IAS-CNR di Capo Granitola operano da anni nell’ambito della diffusione della cultura scientifica, attraverso processi complessi e percorsi di divulgazione in partnership con istituti scolastici del territorio, realizzando attività seminariali, convegni direttamente nelle scuole, nonché visite didattiche guidate degli alunni nei laboratori dell’Istituto ed esperimenti interdisciplinari sull’ambiente marino.
Tali processi divulgativi si sono sviluppati creando numerosi percorsi, in maniera per certi aspetti analoga a quella per cui dalla mescolanza dei tre colori fondamentali si è in grado di ottenere un numero pressoché illimitato di tinte diverse. Lo scopo di questa “mescolanza” è stato quello di ottenere un ventaglio di competenze e strumentazioni che consentissero di indagare i differenti aspetti dell’ecosistema marino da diversi punti di vista ed in maniera sinergica, tale da restituire un quadro il più ricco possibile di “tinte” e particolari. (Scienza e arte di Salvatore Mazzola)
La Scienza e l'immaginario di Angela Cuttitta.
Il progetto “La Scienza e l’Immaginario” nasce dalla collaborazione tra l’IAS - CNR di Capo Granitola e l’Accademia di Belle Arti di Palermo, che attraverso un approccio multidisciplinare ha voluto sperimentare l’unione tra il mondo scientifico e quello artistico, mettendo i giovani artisti, attraverso proiezioni e seminari scientifici, nelle condizioni di scoprire il mondo dell’ambiente marino e degli ecosistemi in esso presenti. Il progetto è nato dalla consapevolezza di come sia necessario operare sul piano della diffusione e divulgazione della cultura scientifica nei più vasti contesti sociali, a partire dall’ambito scolastico. Le azioni divulgative mirano, infatti, a diffondere la conoscenza dei processi geologici, chimico-fisici, climatici e biologici in modo pervasivo, non limitato a singole categorie/settori. La funzione strategica di tali azioni è quella di stimolare idee ed iniziative nonché di sviluppare una maggiore sensibilità nei confronti dei fenomeni che ci circondano, quale presupposto essenziale per una corretta programmazione politico-gestionale.
Lo spirito che ha mosso tutte gli attori del progetto è stato quello di sensibilizzare gli studenti nei confronti della tutela delle risorse marine proprie del loro territorio e di sviluppare e promuovere la cultura come volano dello sviluppo sostenibile, della pace e dell’integrazione sociale, in armonia con quanto indicato dal Consiglio Europeo di Lisbona 2000. Grazie al lavoro di docenti e di ricercatori, l’arte come forma espressiva si è rivelata uno strumento valido e innovativo di divulgazione della cultura scientifica e ha portato alla creazione di suggestioni sui ragazzi che hanno percepito e realizzato forme e armonie espresse in questa mostra. L’impegno per questa manifestazione rappresenta, quindi, un appuntamento importante con le forze vive siciliane nel campo delle scienze del mare segnatamente ad esperti di biologia, chimica, fisica ed al mondo fantastico dell’arte, al fine di esprimere con le varie tecniche pittoriche un momento di riflessione culturale
Teaching percutaneous procedures in critical care: the effect of model fidelity on training skills to perform in patient care
Titrated safe extubation: application of an original strategy for safe management of perioperative glottis edema with severe upper airway obstruction.
Sir: Usual approach to traumatic
laryngeal oedema with glottis
obstruction can be harmful.
Long-term orotracheal intubation and
a prolonged stay of airway exchange
catheters (AECs) could make the
patient suffer new lesions [1]; therefore
bed immobility and ICU stay
could be prolonged. Airway emergencies
during tracheal extubation
phase are still associated with death
or brain damage, indicating that
additional management strategies are
required to improve patient safety [2].
We report the application of new
approach to safe extubation in a case
of iatrogenic upper airways obstruction
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