A target guided subband filter for acoustic event detection in noisy environments using wavelet packets

This paper deals with acoustic event detection (AED), such as screams, gunshots, and explosions, in noisy environments. The main aim is to improve the detection performance under adverse conditions with a very low signal-to-noise ratio (SNR). A novel filtering method combined with an energy detector is presented. The wavelet packet transform (WPT) is first used for time-frequency representation of the acoustic signals. The proposed filter in the wavelet packet domain then uses a priori knowledge of the target event and an estimate of noise features to selectively suppress the background noise. It is in fact a content-aware band-pass filter which can automatically pass the frequency bands that are more significant in the target than in the noise. Theoretical analysis shows that the proposed filtering method is capable of enhancing the target content while suppressing the background noise for signals with a low SNR. A condition to increase the probability of correct detection is also obtained. Experiments have been carried out on a large dataset of acoustic events that are contaminated by different types of environmental noise and white noise with varying SNRs. Results show that the proposed method is more robust and better adapted to noise than ordinary energy detectors, and it can work even with an SNR as low as -15 dB. A practical system for real time processing and multi-target detection is also proposed in this work

Black Holes as the source of the dark energy: a stringent test with the high-redshift JWST AGNs

It has been suggested that there is evidence for cosmological coupling of black holes (BHs) with an index of $k\approx 3$ and hence the BHs serve as the astrophysical source of the dark energy. The data sample however is limited for the redshifts $\leq 2.5$. Recently, the James Webb Space Telescope (JWST) has detected more than 180 high-redshift Active Galactic Nuclei (AGNs) and quasars. Among the JWST NIRSpec/NIRCam resolved AGNs, three are identified in early-type host galaxies with a redshift $z\sim 4.5-7$. Their $M_{\star}$ and $M_{\rm BH}$, however, are in tension with the prediction of the cosmological coupling of black holes with $k=3$ at a confidence level of $\sim 3\sigma$, which is not in support of the hypothesis that BHs serve as the origin of dark energy. The future observations of high-redshift AGNs by JWST will further test such a hypothesis by identifying more early-type host galaxies in the higher mass range.Comment: 9 pages, 3 figures, 1 table; Submitted to ApJL. Comments are welcome

White Pepper and Piperine Have Different Effects on Pharmacokinetics of Puerarin in Rats

This study attempted to explore the effects of white pepper and its major component piperine on puerarin administered to rats. Pharmacokinetic parameters of puerarin in rats were determined by oral administration (400 mg/kg) or intravenous injection (40 mg/kg) of puerarin, pretreated with or without white pepper and piperine given orally. Compared to the control group given oral puerarin only, the combined use of piperine (10 or 20 mg/kg) increased the Cmax of puerarin by 1.30-fold or 1.64-fold and the AUC0–∞ by 133% or 157%, respectively. In contrast, coadministration of white pepper (125 or 250 mg/kg) decreased oral absorption of puerarin to 83% or 74%, respectively. On the other hand, pretreatment with piperine orally did not alter the intravenous pharmacokinetics of puerarin, while the AUC of puerarin after intravenous administration was increased by pretreatment with white pepper. The results indicate that pretreatment with piperine or pepper exerts different effects on pharmacokinetics of puerarin administrated via intragastric and intravenous routes. Therefore, it is suggested that the combined application of piperine or white pepper with puerarin should be carefully monitored for potential diet-drug interactions

A density functional theory approach to mushroom-like platinum clusters on palladium-shell over Au core nanoparticles for high electrocatalytic activity

Recently, it was found that Pt clusters deposited on Pd shell over Au core nanoparticles (Au@Pd@Pt NPs) exhibit unusually high electrocatalytic activity for the electro-oxidation of formic acid (P. P. Fang, S. Duan, et al., Chem. Sci., 2011, 2, 531-539). In an attempt to offer an explanation, we used here carbon monoxide (CO) as probed molecules, and applied density functional theory (DFT) to simulate the surface Raman spectra of CO at this core-shell-cluster NPs with a two monolayer thickness of Pd shell and various Pt cluster coverage. Our DFT results show that the calculated Pt coverage dependent spectra fit the experimental ones well only if the Pt clusters adopt a mushroom-like structure, while currently the island-like structure is the widely accepted model, which follows the Volmer-Weber growth mode. This result infers that there should be a new growth mode, i.e., the mushroom growth mode as proposed in the present work, for Au@Pd@Pt NPs. We suggest that such a mushroom-like structure may offer novel active sites, which accounts for the observed high electrocatalytic activity of Au@Pd@Pt NPs.NSF of China[20620130427, 20873114, 21033007]; Ministry of Science and Technology[2011CB808504, 2007CB815303

Discovery of Therapeutic Approaches for Polyglutamine Diseases: A Summary of Recent Efforts

Polyglutamine (PolyQ) diseases are a group of neurodegenerative disorders caused by the expansion of cytosine-adenine-guanine (CAG) trinucleotide repeats in the coding region of specific genes. This leads to the production of pathogenic proteins containing critically expanded tracts of glutamines. Although polyQ diseases are individually rare, the fact that these nine diseases are irreversibly progressive over 10 to 30 years, severely impairing and ultimately fatal, usually implicating the full-time patient support by a caregiver for long time periods, makes their economic and social impact quite significant. This has led several researchers worldwide to investigate the pathogenic mechanism(s) and therapeutic strategies for polyQ diseases. Although research in the field has grown notably in the last decades, we are still far from having an effective treatment to offer patients, and the decision of which compounds should be translated to the clinics may be very challenging. In this review, we provide a comprehensive and critical overview of the most recent drug discovery efforts in the field of polyQ diseases, including the most relevant findings emerging from two different types of approaches-hypothesis-based candidate molecule testing and hypothesis-free unbiased drug screenings. We hereby summarize and reflect on the preclinical studies as well as all the clinical trials performed to date, aiming to provide a useful framework for increasingly successful future drug discovery and development efforts.Project ON.2 SR&TD Integrated Program (NORTE-07-0124-FEDER-000021), co-funded by North Portugal Regional Operational Program (ON.2-O Novo Norte), under the National Strategic Reference Framework, through the European Regional Development Fund (ERDF) and also supported by Fundação para a Ciência e Tecnologia through the project POCI-01-0145-FEDER-016818 (PTDC/NEU-NMC/3648/2014)info:eu-repo/semantics/publishedVersio

Graphene-Based Nanocomposites for Energy Storage

Since the first report of using micromechanical cleavage method to produce graphene sheets in 2004, graphene/graphene-based nanocomposites have attracted wide attention both for fundamental aspects as well as applications in advanced energy storage and conversion systems. In comparison to other materials, graphene-based nanostructured materials have unique 2D structure, high electronic mobility, exceptional electronic and thermal conductivities, excellent optical transmittance, good mechanical strength, and ultrahigh surface area. Therefore, they are considered as attractive materials for hydrogen (H2) storage and high-performance electrochemical energy storage devices, such as supercapacitors, rechargeable lithium (Li)-ion batteries, Li–sulfur batteries, Li–air batteries, sodium (Na)-ion batteries, Na–air batteries, zinc (Zn)–air batteries, and vanadium redox flow batteries (VRFB), etc., as they can improve the efficiency, capacity, gravimetric energy/power densities, and cycle life of these energy storage devices. In this article, recent progress reported on the synthesis and fabrication of graphene nanocomposite materials for applications in these aforementioned various energy storage systems is reviewed. Importantly, the prospects and future challenges in both scalable manufacturing and more energy storage-related applications are discussed

Study of the doubly Cabibbo-suppressed decays Ds+→K+K+π−D^+_s\to K^+K^+\pi^- and Ds+→K+K+π−π0D^+_s\to K^+K^+\pi^-\pi^0

Based on 7.33 fb$^{-1}$ of $e^+e^-$ collision data collected at center-of-mass energies between 4.128 and 4.226 GeV with the BESIII detector, the experimental studies of the doubly Cabibbo-suppressed decays $D^+_s\to K^+K^+\pi^-$ and $D^+_s\to K^+K^+\pi^-\pi^0$ are reported. We determine the absolute branching fraction of $D^+_s\to K^+K^+\pi^-$ to be (${1.23^{+0.28}_{-0.25}}({\rm stat})\pm0.06({\rm syst})$) $\times 10^{-4}$. No significant signal of $D^+_s\to K^+K^+\pi^-\pi^0$ is observed and the upper limit on its decay branching fraction at 90\% confidence level is set to be $1.7\times10^{-4}$.Comment: 10 pages, 4 figures, 4 table

Improved measurement of the decays η′→π+π−π+(0)π−(0)\eta' \to \pi^{+}\pi^{-}\pi^{+(0)}\pi^{-(0)} and search for the rare decay η′→4π0\eta' \to 4\pi^{0}

Using a sample of 10 billion $J/{\psi}$ events collected with the BESIII detector, the decays $\eta' \to \pi^{+}\pi^{-}\pi^{+}\pi^{-}$, $\eta' \to \pi^{+}\pi^{-}\pi^{0}\pi^{0}$ and $\eta' \to 4 \pi^{0}$ are studied via the process $J/{\psi}\to\gamma\eta'$. The branching fractions of $\eta' \to \pi^{+}\pi^{-}\pi^{+}\pi^{-}$ and $\eta' \to \pi^{+}\pi^{-}\pi^{0}$ $\pi^{0}$ are measured to be $( 8.56 \pm 0.25({\rm stat.}) \pm 0.23({\rm syst.}) ) \times {10^{ - 5}}$ and $(2.12 \pm 0.12({\rm stat.}) \pm 0.10({\rm syst.})) \times {10^{ - 4}}$, respectively, which are consistent with previous measurements but with improved precision. No significant $\eta' \to 4 \pi^{0}$ signal is observed, and the upper limit on the branching fraction of this decay is determined to be less than $1.24 \times {10^{-5}}$ at the $90\%$ confidence level. In addition, an amplitude analysis of $\eta' \to \pi^{+}\pi^{-}\pi^{+}\pi^{-}$ is performed to extract the doubly virtual isovector form factor $\alpha$ for the first time. The measured value of $\alpha=1.22 \pm 0.33({\rm stat.}) \pm 0.04({\rm syst.})$, is in agreement with the prediction of the VMD model

Study of the decay J/ψ→ϕπ0ηJ/\psi \to \phi \pi^{0}\eta

Based on $(10.09 \pm 0.04) \times 10^9$ $J/\psi$ events collected with the BESIII detector operating at the BEPCII collider, a partial wave analysis of the decay $J/\psi \to \phi \pi^{0}\eta$ is performed. We observe for the first time two new structures on the $\phi\eta$ invariant mass distribution, with statistical significances of $24.0\sigma$ and $16.9\sigma$; the first with $J^{\rm PC}$ = $1^{+-}$, mass M = (1911 $\pm$ 6 (stat.) $\pm$ 14 (sys.))~MeV/$c^{2}$, and width $\Gamma =$ (149 $\pm$ 12 (stat.) $\pm$ 23 (sys.))~MeV, the second with $J^{\rm PC}$ = $1^{--}$, mass M = (1996 $\pm$ 11 (stat.) $\pm$ 30 (sys.))~MeV/$c^{2}$, and width $\Gamma$ = (148 $\pm$ 16 (stat.) $\pm$ 66 (sys.))~MeV. These measurements provide important input for the strangeonium spectrum. In addition, the $f_0(980)-a_0(980)^0$ mixing signal in $J/\psi \to \phi f_0(980) \to \phi a_0(980)^0$ and the corresponding electromagnetic decay $J/\psi \to \phi a_0(980)^0$ are measured with improved precision, providing crucial information to understand the nature of $a_0(980)^0$ and $f_0(980)$