480 research outputs found
Antimicrobial effects of pulsed electromagnetic fields from commercially available water treatment devices – controlled studies under static and flow conditions
- Author
- Publication venue
- 'Wiley'
- Publication date
- 01/03/2018
- Field of study
Search for new phenomena in final states with an energetic jet and large missing transverse momentum in pp collisions at √ s = 8 TeV with the ATLAS detector
- Author
- Aad G
- Abbott B
- Abbott DC
- Abeling K
- Abhayasinghe DK
- Abidi SH
- AbouZeid OS
- Abraham NL
- Abramowicz H
- Abreu H
- Abud AA
- Abulaiti Y
- Acharya BS
- Achkar B
- Adachi S
- Adam L
- Adamczyk L
- Adamek L
- Adelman J
- Adersberger M
- Adiguzel A
- Adorni S
- Adye T
- Affolder AA
- Afik Y
- Agapopoulou C
- Agaras MN
- Aggarwal A
- Agheorghiesei C
- Aguilar-Saavedra JA
- Ahmadov F
- Ahmed WS
- Ai X
- Aielli G
- Akatsuka S
- Akesson TPA
- Akilli E
- Akimov A
- Al Khoury K
- Alberghi GL
- Albert J
- Alderweireldt S
- Aleksa M
- Aleksandrov IN
- Alexa C
- Alexopoulos T
- Alfonsi A
- Alfonsi F
- Alhroob M
- Ali B
- Aliev M
- Alimonti G
- Allaire C
- Allbrooke BMM
- Allen BW
- Allport PP
- Aloisio A
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- Alviggi MG
- Amaral Coutinho Y
- Ambler A
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- Amelung C
- Amidei D
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- Amoroso S
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- An F
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- Anelli CR
- Angelidakis S
- Angerami A
- Anisenkov A
- Annovi A
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- Antipov E
- Antonelli M
- Antrim DJA
- Anulli F
- Aoki M
- Aparisi Pozo JA
- Araque JP
- Araujo Ferraz V
- Araujo Pereira R
- Araya ST
- Arcangeletti C
- Arce ATH
- Arduh FA
- Arguin J-F
- Argyropoulos S
- Arling J-H
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- Astigarraga MEP
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- Zhemchugov A
- Zheng Z
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- Zinonos Z
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- Zivkovic L
- Zobernig G
- Zoccoli A
- Zoch K
- Zorbas TG
- Zou R
- Zu Theenhausen HM
- Zwalinski L
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2015
- Field of study
Results of a search for new phenomena in final states with an energetic jet and large missing transverse momentum are reported. The search uses 20.3 fb−1 of √ s = 8 TeV data collected in 2012 with the ATLAS detector at the LHC. Events are required to have at least one jet with pT > 120 GeV and no leptons. Nine signal regions are considered with increasing missing transverse momentum requirements between Emiss T > 150 GeV and Emiss T > 700 GeV. Good agreement is observed between the number of events in data and Standard Model expectations. The results are translated into exclusion limits on models with either large extra spatial dimensions, pair production of weakly interacting dark matter candidates, or production of very light gravitinos in a gauge-mediated supersymmetric model. In addition, limits on the production of an invisibly decaying Higgs-like boson leading to similar topologies in the final state are presente
Serotonergic chemosensory neurons modify the <i>C. elegans</i> immune response by regulating G-protein signaling in epithelial cells
- Author
- A Serafeim
- AD Johnson
- Alexandra Anderson
- BAB Faraj
- D O'Rourke
- D Weinshenker
- DC Chugani
- DJ Walther
- E Pradel
- E Sawin
- EA Evans
- EC Nowak
- Frederick A. Partridge
- Frederick M. Ausubel
- G Gürel
- G Jafari
- GG Aspöck
- GP Ahern
- H Nicholas
- H Schulenburg
- Henry Laurenson-Schafer
- HR Horvitz
- I Lucki
- J Hodgkin
- J Mendel
- J Sun
- J Sze
- JJ Rodríguez
- Jonathan Hodgkin
- JPM M R Young
- K Iken
- K MILLER
- K Yook
- KA Brogden
- L Avery
- L Ségalat
- L Waggoner
- M Carre-Pierrat
- M Estevez
- M Gravato-Nobre
- M Idzko
- M Lackner
- M Levite
- MAM Bunin
- ME Hernandez
- MG Frank
- MM Irwin
- MR Koelle
- MY Chao
- NL Baganz
- NM Kushnir-Sukhov
- O Zugasti
- R Glaser
- R McMullan
- R McMullan
- R Ranganathan
- R Shivers
- Rachel McMullan
- RJR Hobson
- RS Smith
- S Brenner
- S Nurrish
- SAS Boehme
- SW Flavell
- T Akimkina
- T Kawli
- X Zheng
- Y Teng
- Y Zhang
- YMY Hajdu-Cronin
- YY Qin
- Z Mikulski
- Publication venue
- 'Public Library of Science (PLoS)'
- Publication date
- 12/12/2013
- Field of study
The nervous and immune systems influence each other, allowing animals to rapidly protect themselves from changes in their internal and external environment. However, the complex nature of these systems in mammals makes it difficult to determine how neuronal signaling influences the immune response. Here we show that serotonin, synthesized in Caenorhabditis elegans chemosensory neurons, modulates the immune response. Serotonin released from these cells acts, directly or indirectly, to regulate G-protein signaling in epithelial cells. Signaling in these cells is required for the immune response to infection by the natural pathogen Microbacterium nematophilum. Here we show that serotonin signaling suppresses the innate immune response and limits the rate of pathogen clearance. We show that C. elegans uses classical neurotransmitters to alter the immune response. Serotonin released from sensory neurons may function to modify the immune system in response to changes in the animal's external environment such as the availability, or quality, of food
Entomological aspects and the role of human behaviour in malaria transmission in a highland region of the Republic of Yemen
- Author
- A Al-Taiar
- A Al-Taiar
- A Al-Taiar
- A Habluetzel
- A Kroeger
- A Lenhart
- A Mahande
- A Taye
- AA Hamad
- Ahmed Azazy
- AK Githeko
- AM Abdoon
- AM Al-Mekhlafi
- AM Mahande
- Andrew G. Briscoe
- BL Sharp
- BO Ralisoa Randrianasolo
- C Costantini
- C Drakeley
- C Faraj
- CM Fornadel
- EA Temu
- ES Krafsur
- FH Collins
- G Barnish
- GB White
- GB White
- Githeko AK Service MW, Mbogo CM, Atieli FK, Juma FO
- Githeko AK Service MW, Mbogo CM, Atieli FK, Juma FO
- Guy Barnish
- H Abdalla
- H Townson
- HO Alkadi
- I Tirados
- J Shililu
- J Shililu
- JA Rozendaal
- JA Scott
- JC Beier
- JI Glick
- JI Shililu
- JM Mwangangi
- KA Taylor
- KL Knight
- L Merucci
- LA Kelly-Hope
- Louise Kelly-Hope
- M Maffi
- M Rowland
- M Zaim
- MA Farid
- MA Kenawy
- MA Kenawy
- MA Kulkarni
- MC Thomson
- MD Wilson
- MG Shehata
- MQA Abdulsalam
- MT Al-Maktari
- MT Gillies
- MT Gillies
- N Cuzin-Ouattara
- NU Ahmed
- O Faye
- P Ashe
- PA Buxton
- PF Mattingly
- Philip J. McCall
- R Thompson
- RA Mount
- RA Wirtz
- Ralph E. Harbach
- RE Harbach
- RJ Kent
- RL Kouznetsov
- RW Snow
- S Al-Hamidhi
- S Cook
- S Hewitt
- Samira M. A. Al-Eryani
- SF Altschul
- SI Hay
- T Mzilahowa
- TK Mukiama
- W Daoud
- WW Macdonald
- Z Salternik
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2016
- Field of study
© 2016 Al-Eryani et al. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/ publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. The attached file is the published version of the article
Crowdsourcing Coordination: A Review and Research Agenda for Crowdsourcing Coordination Used for Macro-tasks
- Author
- A Kankanhalli
- A Khuong
- BA Bechky
- BA Bechky
- D Haas
- DE Strode
- DM Wegner
- DP Brandon
- F Bolici
- F Heylighen
- F Heylighen
- GA Okhuysen
- H Schmitz
- HP Andres
- J Howe
- J Lave
- J Lave
- J Lave
- J Windeler
- JH Gittell
- JH Gittell
- JH Gittell
- JH Gittell
- JR Austin
- JY Jung
- K Crowston
- K Lewis
- KA Jehn
- L Suchman
- LP Robert
- LP Robert Jr
- M Alavi
- MA Valentine
- MM Montoya-Weiss
- MR Endsley
- MS Feldman
- O Holland
- P Marques-Quinteiro
- P Valckenaers
- PS Adler
- RL Moreland
- S Faraj
- S Paul
- SY Choi
- TW Malone
- Y Ren
- Publication venue
- Springer Nature
- Publication date
- 10/08/2019
- Field of study
Crowdsourcing has become a widely accepted approach to leveraging the skills and expertise of others to accomplish work. Despite the potential of crowdsourcing to tackle complex problems, it has often been used to address simple micro-tasks. To tackle more complex macro-tasks, more attention is needed to better comprehend crowd coordination. Crowd coordination is defined as the synchronization of crowd workers in an attempt to direct and align their efforts in pursuit of a shared goal. The goal of this chapter is to advance our understanding of crowd coordination to tackle complex macro-tasks. To accomplish this, we have three objectives. First, we review popular theories of coordination. Second, we examine the current approaches to crowd coordination in the HCI and CSCW literature. Finally, the chapter identifies shortcomings in the literature and proposes a research agenda directed at advancing our understanding of crowd coordination needed to address complex macro-tasks.National Science Foundation grant CHS-1617820Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/150620/1/Kim and Robert 2019 Preprint Chapter 2.pdfDescription of Kim and Robert 2019 Preprint Chapter 2.pdf : Preprint Versio
Prognostic model to predict postoperative acute kidney injury in patients undergoing major gastrointestinal surgery based on a national prospective observational cohort study.
- Author
- Aamir A
- Abbas J
- Abbas N
- Abbott TEF
- Abdalla M
- Abdikadir H
- Abuhussein N
- Acquaah F
- Adamson R
- Adeleye O
- Adeogun A
- Adlan A
- Aftab R
- Afzal Z
- Agarwal M
- Aglan H
- Agnew CJF
- Agrawal R
- Ahern D
- Ahluwalia J
- Ahluwalia V
- Ahmad A
- Ahmad K
- Ahmed H
- Ahmed I
- Ahmed L
- Ahmed N
- Ahmed P
- Ainger E
- Ainsworth P
- Aishwarya G
- Ajibola-Taylor O
- Akhbari M
- Akhtar A
- Akhtar R
- Akpenyi O
- Al-Ausi M
- Al-Huneidi R
- Al-Khudairi R
- Al-Masri S
- Al-Mousawi A
- Al-Saadi N
- Alagappan A
- Alberts J
- Alfa-Wali M
- Ali A
- Ali B
- Ali I
- Ali M
- Ali Q
- Ali S
- Alturki N
- Alwandi A
- Amani L
- Amarnath T
- Amer M
- Amin H
- Amin MN
- Amoah R
- Amoah-Arko A
- Anandarajah C
- Ananthavarathan P
- Andah EJE
- Andrew K
- Andrews H
- Ang A
- Ang HL
- Ang JJ
- Ani C
- Anilkumar A
- Anto N
- Anwar S
- Apperley H
- Appleton S
- Aquilina T
- Archer M
- Arif T
- Arneill M
- Arnell S
- Arnold TJ
- Arshad A
- Arthur J
- Arulkumaran N
- Arya J
- Asad M
- Asemota N
- Ashaye T
- Ashdown T
- Ashour R
- Ashraf MR
- Ashwood J
- Asif U
- Atkin G
- Atkins B
- Attalla M
- Aubrey-Jones D
- Auckburally S
- Auld F
- Auluck I
- Azam S
- Aziz R
- Azizi A
- Azmi F
- Babatunde F
- Babu VS
- Bachi A
- Bagga R
- Bains H
- Bajwa DS
- Baker A
- Baker C
- Balai E
- Balian V
- Ball M
- Bamford M
- Bana R
- Banfield DA
- Bannard-Smith J
- Barai I
- Barclay J
- Barfi L
- Barker C
- Barker M
- Barmayehvar B
- Barnfield J
- Barnor-Ahiaku E
- Baron C
- Barr CJ
- Barraclough J
- Baryan HK
- Basra M
- Bassam N
- Bath MF
- Battle J
- Beasley W
- Beattie G
- Beattie S
- Beatty M
- Beghal G
- Begum F
- Behranwala K
- Belchos J
- Belgaid DR
- Belgaumkar A
- Bell S
- Ben-Gal O
- Benchetrit S
- Bennett M
- Benons N
- Bernal TL
- Bertelli M
- Berthaume-Hawkins SD
- Best R
- Betts A
- Bevan K
- Bews-Hair M
- Bhambra R
- Bhamra N
- Bhangu A
- Bhatte S
- Bhatti A
- Bhide I
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- Bhullar S
- Bienias A
- Billyard C
- Bird C
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- Bleakley A
- Bloom I
- Bogle R
- Bolton W
- Borakati A
- Boraluwe-Rallage H
- Borg CM
- Botha A
- Boualbanat Y
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- Bristow S
- Britton N
- Broad J
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- Burns N
- Burrows A
- Busti S
- Butler A
- Cabdi NMO
- Cadden F
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- Campbell A
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- Campbell G
- Campbell HS
- Cannon SP
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- Carr G
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- Cato L
- Cave D
- Cecil E
- Chadwick H
- Chadwick M
- Chan F
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- Chan SSN
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- Chandler E
- Chandler S
- Chandramoorthy L
- Chandramoorthy S
- Chang A
- Chang LH
- Chang M
- Chappelow I
- Chapple K
- Charnley R
- Chaudhry A
- Chaudhry S
- Chauhan P
- Chavan A
- Chean CS
- Chen L
- Chen Y
- Chenciner L
- Cheng J
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- Cheung W
- Chin YR
- China Z
- Chitsabesan P
- Chohan K
- Choi JE
- Chong A
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- Choo S
- Chopada A
- Chouari T
- Choudhary Y
- Choudhry M
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- Christopher E
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- Chui J
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- Clements B
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- Cole A
- Coleman M
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- Collins J
- Collishaw A
- Common M
- Concannon K
- Conchie H
- Connelly A
- Connor M
- Cookson P
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- Cope T
- Copeland M
- Copley HC
- Coppel J
- Corbridge O
- Cotter M
- Courquin GR
- Court J
- Cox L
- Craig ARJ
- Craig N
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- Cresswell B
- Crewe A
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- Cummings D
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- Cunningham L
- Curtis A
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- D'Auria M
- D'Souza F
- Dada J
- Dalal F
- Dalrymple J
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- Skulsky S
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- STARSurg Collaborative Writing Committee, Data analysis, Steering committee, Advisory group, Regional leads, Collaborators and validators
- STARSurg Collaborative Writing Committee, Data analysis, Steering committee, Advisory group, Regional leads, Collaborators and validators, Nepogodiev, D
- Stechman M
- Stewart D
- Stewart E
- Stewart H
- Stewart R
- Stickler E
- Stoddart MT
- Stokes E
- Stott G
- Strang S
- Stringer H
- Stringfellow TD
- Stubbing-Moore A
- Sturrock S
- Subar D
- Subratty SM
- Sukirthan N
- Sukumar S
- Sulaiman SK
- Sultan S
- Sun L
- Sundaram K
- Suresh R
- Suresh S
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- Tilliridou V
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- Torrance HD
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- Trevett J
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- Tsang JCH
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- Turner J
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- Whitcroft I
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- White P
- Whitham R
- Whyte M
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- Wiffen L
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- Xu Y
- Yahaya AA
- Yalamarthi S
- Yang DD
- Yang N
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- Yarham E
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- Zaat S
- Zanichelli D
- Zaver V
- Zeng R
- Zhang Y
- Zheleniakova T
- Zhu Y
- Zornoza A
- Zubikarai G
- Zulkifli A
- Zuzarte L
- Publication venue
- 'Wiley'
- Publication date
- 18/05/2018
- Field of study
Background: Acute illness, existing co-morbidities and surgical stress response can all contribute to postoperative acute kidney injury (AKI) in patients undergoing major gastrointestinal surgery. The aim of this study was prospectively to develop a pragmatic prognostic model to stratify patients according to risk of developing AKI after major gastrointestinal surgery. Methods: This prospective multicentre cohort study included consecutive adults undergoing elective or emergency gastrointestinal resection, liver resection or stoma reversal in 2-week blocks over a continuous 3-month period. The primary outcome was the rate of AKI within 7 days of surgery. Bootstrap stability was used to select clinically plausible risk factors into the model. Internal model validation was carried out by bootstrap validation. Results: A total of 4544 patients were included across 173 centres in the UK and Ireland. The overall rate of AKI was 14·2 per cent (646 of 4544) and the 30-day mortality rate was 1·8 per cent (84 of 4544). Stage 1 AKI was significantly associated with 30-day mortality (unadjusted odds ratio 7·61, 95 per cent c.i. 4·49 to 12·90; P < 0·001), with increasing odds of death with each AKI stage. Six variables were selected for inclusion in the prognostic model: age, sex, ASA grade, preoperative estimated glomerular filtration rate, planned open surgery and preoperative use of either an angiotensin-converting enzyme inhibitor or an angiotensin receptor blocker. Internal validation demonstrated good model discrimination (c-statistic 0·65). Discussion: Following major gastrointestinal surgery, AKI occurred in one in seven patients. This preoperative prognostic model identified patients at high risk of postoperative AKI. Validation in an independent data set is required to ensure generalizability
Global age-sex-specific fertility, mortality, healthy life expectancy (HALE), and population estimates in 204 countries and territories, 1950-2019 : a comprehensive demographic analysis for the Global Burden of Disease Study 2019
- Author
- Abbas KM
- Abbasi-Kangevari M
- Abbasifard M
- Abbastabar H
- Abd El Razek HM
- Abd El Razek MM
- Abd-Allah F
- Abdelalim A
- Abdulkader RS
- Abdullah KH
- Abolhassani H
- Abreu LG
- Abrigo MRM
- Abushouk AI
- Adabi M
- Adair T
- Adebayo OM
- Adedeji IA
- Adekanmbi V
- Adeoye AM
- Adetokunboh OO
- Advani SM
- Afshin A
- Aghaali M
- Agrawal A
- Ahmadi K
- Ahmadieh H
- Ahmed MB
- Al-Aly Z
- Al-Mekhlafi HM
- Alam K
- Alam T
- Alanezi FM
- Alanzi TM
- Alcalde-Rabanal JE
- Ali M
- Alicandro G
- Alijanzadeh M
- Alinia C
- Alipour V
- Alizade H
- Aljunid SM
- Allebeck P
- Almadi MAH
- Almasi-Hashiani A
- Altirkawi KA
- Alumran AK
- Alvis-Guzman N
- Amini-Rarani M
- Aminorroaya A
- Amit AML
- Ancuceanu R
- Andrei CL
- Androudi S
- Angus C
- Anjomshoa M
- Ansari F
- Ansari I
- Ansari-Moghaddam A
- Antonio CAT
- Antony CM
- Anvari D
- Appiah SCY
- Arab-Zozani M
- Arabloo J
- Aravkin AY
- Aremu O
- Arnlov J
- Aryal KK
- Asadi-Pooya AA
- Asgari S
- Atteraya MS
- Ausloos M
- Avila-Burgos L
- Avokpaho EFGA
- Ayano G
- Ayanore MA
- Azarian G
- Babaee E
- Badiye AD
- Bagli E
- Bahrami MA
- Bakhtiari A
- Balassyano S
- Bali AO
- Banach M
- Bandpei MAM
- Banik PC
- Barker-Collo SL
- Barnighausen TW
- Barzegar A
- Basu S
- Baune BT
- Bayati M
- Bazmandegan G
- Bedi N
- Bell ML
- Bennett DA
- Bensenor IM
- Berhe K
- Berman AE
- Bertolacci GJ
- Bhageerathy R
- Bhala N
- Bhattacharyya K
- Bhutta ZA
- Bijani A
- Bin Zaman S
- Biondi A
- Bisanzio D
- Bisignano C
- Biswas RK
- Bjrge T
- Bohlouli S
- Bohluli M
- Bolla SRR
- Borzi AM
- Borzouei S
- Brady OJ
- Braithwaite D
- Brauer M
- Briko AN
- Briko NI
- Bumgarner BR
- Butt ZA
- Cai T
- Callender CSKH
- Camera LLAA
- Campos-Nonato IR
- Car LT
- Cardenas R
- Carreras G
- Carrero JJ
- Carvalho F
- Castaldelli-Maia JM
- Castelpietra G
- Castro F
- Catala-Lopez F
- Cederroth CR
- Cerin E
- Chattu VK
- Chin KL
- Chu D-T
- Ciobanu LG
- Cirillo M
- Comfort H
- Costa VM
- Cowden RG
- Cromwell EA
- Croneberger AJ
- Cunningham M
- D'Amico E
- da Silva DD
- Dahlawi SMA
- Damiani G
- Dandona L
- Dandona R
- Dargan PI
- Darwesh AM
- Daryani A
- Das Gupta R
- das Neves J
- Davletov K
- De Leo D
- Defo BK
- Denova-Gutierrez E
- Deribe K
- Dervenis N
- Desai R
- Dhungana GP
- Diaz D
- Dippenaar IN
- Djalalinia S
- Do HT
- Dokova K
- Doku DT
- Dorostkar F
- dos Santos FLC
- Doshi CP
- Doshmangir L
- Doyle KE
- Dubljanin E
- Duraes AR
- Edvardsson D
- Effiong A
- El Sayed I
- El Tantawi M
- El-Jaafary SI
- Elbarazi I
- Emamian MH
- Eskandarieh S
- Esmaeilzadeh F
- Estep K
- Farahmand M
- Faraj A
- Fareed M
- Faridnia R
- Faro A
- Farzadfar F
- Fattahi N
- Fazaeli AA
- Fazlzadeh M
- Feigin VL
- Fereshtehnejad S-M
- Fernandes E
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- Filip I
- Fischer F
- Flohr C
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- Fuller JE
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- Heibati B
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- Mirrakhimov EM
- Mirzaei H
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- Musa KI
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- Pourjafar H
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- Prada SI
- Prakash S
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- Quintanilla BPA
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- Rafiei A
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- Schwendicke F
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- Senbeta AM
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- Sepanlou SG
- Servan-Mori E
- Shabani M
- Shahabi S
- Shahbaz M
- Shaheen AA
- Shaikh MA
- Shalash AS
- Shams-Beyranvand M
- Shamsi M
- Shamsizadeh M
- Shannawaz M
- Sharafi K
- Sharafi Z
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- Taherkhani A
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- Upadhyay E
- Vacante M
- Vakilian A
- Valdez PR
- Valli A
- Vardavas C
- Vasankari TJ
- Vasconcelos AMN
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- Veisani Y
- Velasquez IM
- Venketasubramanian N
- Vidale S
- Violante FS
- Vlassov V
- Vollset SE
- Vos T
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- Waheed Y
- Wallin MT
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- Wang Y-P
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- Weldesamuel GT
- Werdecker A
- Westerman R
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- York HW
- Younis MZ
- Younker TP
- Yousefi Z
- Yousefinezhadi T
- Yousuf AY
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- Zakzuk J
- Zamani M
- Zamanian M
- Zandian H
- Zhang Z-J
- Zheng P
- Zhou M
- Ziapour A
- Publication venue
- Publication date
- 01/01/2020
- Field of study
Background Accurate and up-to-date assessment of demographic metrics is crucial for understanding a wide range of social, economic, and public health issues that affect populations worldwide. The Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2019 produced updated and comprehensive demographic assessments of the key indicators of fertility, mortality, migration, and population for 204 countries and territories and selected subnational locations from 1950 to 2019. Methods 8078 country-years of vital registration and sample registration data, 938 surveys, 349 censuses, and 238 other sources were identified and used to estimate age-specific fertility. Spatiotemporal Gaussian process regression (ST-GPR) was used to generate age-specific fertility rates for 5-year age groups between ages 15 and 49 years. With extensions to age groups 10-14 and 50-54 years, the total fertility rate (TFR) was then aggregated using the estimated age-specific fertility between ages 10 and 54 years. 7417 sources were used for under-5 mortality estimation and 7355 for adult mortality. ST-GPR was used to synthesise data sources after correction for known biases. Adult mortality was measured as the probability of death between ages 15 and 60 years based on vital registration, sample registration, and sibling histories, and was also estimated using ST-GPR. HIV-free life tables were then estimated using estimates of under-5 and adult mortality rates using a relational model life table system created for GBD, which closely tracks observed age-specific mortality rates from complete vital registration when available. Independent estimates of HIV-specific mortality generated by an epidemiological analysis of HIV prevalence surveys and antenatal clinic serosurveillance and other sources were incorporated into the estimates in countries with large epidemics. Annual and single-year age estimates of net migration and population for each country and territory were generated using a Bayesian hierarchical cohort component model that analysed estimated age-specific fertility and mortality rates along with 1250 censuses and 747 population registry years. We classified location-years into seven categories on the basis of the natural rate of increase in population (calculated by subtracting the crude death rate from the crude birth rate) and the net migration rate. We computed healthy life expectancy (HALE) using years lived with disability (YLDs) per capita, life tables, and standard demographic methods. Uncertainty was propagated throughout the demographic estimation process, including fertility, mortality, and population, with 1000 draw-level estimates produced for each metric. Findings The global TFR decreased from 2.72 (95% uncertainty interval [UI] 2.66-2.79) in 2000 to 2.31 (2.17-2.46) in 2019. Global annual livebirths increased from 134.5 million (131.5-137.8) in 2000 to a peak of 139.6 million (133.0-146.9) in 2016. Global livebirths then declined to 135.3 million (127.2-144.1) in 2019. Of the 204 countries and territories included in this study, in 2019, 102 had a TFR lower than 2.1, which is considered a good approximation of replacement-level fertility. All countries in sub-Saharan Africa had TFRs above replacement level in 2019 and accounted for 27.1% (95% UI 26.4-27.8) of global livebirths. Global life expectancy at birth increased from 67.2 years (95% UI 66.8-67.6) in 2000 to 73.5 years (72.8-74.3) in 2019. The total number of deaths increased from 50.7 million (49.5-51.9) in 2000 to 56.5 million (53.7-59.2) in 2019. Under-5 deaths declined from 9.6 million (9.1-10.3) in 2000 to 5.0 million (4.3-6.0) in 2019. Global population increased by 25.7%, from 6.2 billion (6.0-6.3) in 2000 to 7.7 billion (7.5-8.0) in 2019. In 2019, 34 countries had negative natural rates of increase; in 17 of these, the population declined because immigration was not sufficient to counteract the negative rate of decline. Globally, HALE increased from 58.6 years (56.1-60.8) in 2000 to 63.5 years (60.8-66.1) in 2019. HALE increased in 202 of 204 countries and territories between 2000 and 2019. Interpretation Over the past 20 years, fertility rates have been dropping steadily and life expectancy has been increasing, with few exceptions. Much of this change follows historical patterns linking social and economic determinants, such as those captured by the GBD Socio-demographic Index, with demographic outcomes. More recently, several countries have experienced a combination of low fertility and stagnating improvement in mortality rates, pushing more populations into the late stages of the demographic transition. Tracking demographic change and the emergence of new patterns will be essential for global health monitoring. Copyright (C) 2020 The Author(s). Published by Elsevier Ltd.Peer reviewe
Global burden of 369 diseases and injuries in 204 countries and territories, 1990-2019: a systematic analysis for the Global Burden of Disease Study 2019
- Author
- Abbafati C
- Abbas KM
- Abbasi M
- Abbasi-Kangevari M
- Abbasifard M
- Abbastabar H
- Abd El Razek HM
- Abd El Razek MM
- Abd-Allah F
- Abdelalim A
- Abdollahi M
- Abdollahpour I
- Abdulkader RS
- Abdullah KH
- Abedi A
- Abedi P
- Abegaz KH
- Abolhassani H
- Abosetugn AE
- Aboyans V
- Abrams EM
- Abreu LG
- Abrigo MRM
- Abu Haimed AK
- Abu-Gharbieh E
- Abu-Raddad LJ
- Abualhasan A
- Abushouk AI
- Acebedo A
- Ackerman IN
- Adabi M
- Adair T
- Adamu AA
- Adebayo OM
- Adedeji IA
- Adekanmbi V
- Adelson JD
- Adeoye AM
- Adetokunboh OO
- Adham D
- Advani SM
- Afarideh M
- Afshari M
- Afshin A
- Agardh EE
- Agarwal G
- Agasthi P
- Agesa KM
- Aghaali M
- Aghamir SMK
- Agrawal A
- Ahmad T
- Ahmadi A
- Ahmadi K
- Ahmadi M
- Ahmadieh H
- Ahmadpour E
- Ahmed MB
- Aji B
- Akalu TY
- Akinyemi RO
- Akinyemiju T
- Akombi B
- Akunna CJ
- Al-Aly Z
- Al-Mekhlafi HM
- Al-Raddadi RM
- Alahdab F
- Alam K
- Alam N
- Alam S
- Alam T
- Alanezi FM
- Alanzi TM
- Albertson SB
- Alcalde-Rabanal JE
- Alema NM
- Alemu BW
- Alemu YM
- Alhabib KF
- Alhassan RK
- Ali M
- Ali S
- Alicandro G
- Alijanzadeh M
- Alinia C
- Alipour V
- Alizade H
- Aljunid SM
- Alla F
- Allebeck P
- Almadi MAH
- Almasi A
- Almasi-Hashiani A
- Almasri NA
- Almulhim AM
- Alonso J
- Altirkawi KA
- Alumran AK
- Alvis-Guzman N
- Alvis-Zakzuk NJ
- Amare AT
- Amare B
- Amini S
- Amini-Rarani M
- Aminorroaya A
- Amiri F
- Amit AML
- Amugsi DA
- Amul GGH
- Anbesu EW
- Ancuceanu R
- Anderlini D
- Anderson JA
- Andrei CL
- Andrei T
- Androudi S
- Angus C
- Anjomshoa M
- Ansari F
- Ansari I
- Ansari-Moghaddam A
- Antonazzo IC
- Antonio CAT
- Antony CM
- Antriyandarti E
- Anvari D
- Anwer R
- Appiah SCY
- Arab-Zozani M
- Arabloo J
- Aravkin AY
- Arba AAK
- Aremu O
- Ariani F
- Aripov T
- Armoon B
- Arnlov J
- Arowosegbe OO
- Aryal KK
- Arzani A
- Asaad M
- Asadi-Aliabadi M
- Asadi-Pooya AA
- Asgari S
- Asghari B
- Ashbaugh C
- Assmus M
- Atafar Z
- Athari SS
- Atnafu DD
- Atout MMW
- Atre SR
- Atteraya MS
- Ausloos F
- Ausloos M
- Avila-Burgos L
- Avokpaho EFGA
- Ayano G
- Ayanore MA
- Aynalem GL
- Aynalem YA
- Ayza MA
- Azari S
- Azarian G
- Azene ZN
- Azhar G
- Azzopardi PS
- Babaee E
- Badawi A
- Badiye AD
- Bagherzadeh M
- Bagli E
- Bahrami MA
- Baig AA
- Bairwa M
- Bakhshaei MH
- Bakhtiari A
- Bakkannavar SM
- Balachandran A
- Balakrishnan S
- Balalla S
- Balassyano S
- Baldasseroni A
- Bali AO
- Ball K
- Ballew SH
- Balzi D
- Banach M
- Bandpei MAM
- Banerjee SK
- Banik PC
- Bannick MS
- Bante AB
- Bante SA
- Baraki AG
- Barboza MA
- Barker-Collo SL
- Barnighausen TW
- Barrero LH
- Barthelemy CM
- Barua L
- Barzegar A
- Basaleem H
- Bassat Q
- Basu S
- Baune BT
- Bayati M
- Baye BA
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- Sultan I
- Swope CB
- Sykes BL
- Sylte DO
- Szocska M
- Szumowski L
- Tabares-Seisdedos R
- Tabb KM
- Tabuchi T
- Tadakamadla SK
- Taddele BW
- Tadesse DB
- Taherkhani A
- Tahir Z
- Tajdini M
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- Tarigan IU
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- Teklehaimanot BF
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- Troeger CE
- Truelsen TC
- Tsai AC
- Tsatsakis A
- Tyrovolas S
- Uddin R
- Ullah I
- Ullah S
- Umeokonkwo CD
- Undurraga EA
- Unnikrishnan B
- Upadhyay E
- Uthman OA
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- Vaicekonyte R
- Vakilian A
- Valdez PR
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- Venketasubramanian N
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- Wickramasinghe ND
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- Woldu G
- Wolfe CDA
- Wondmeneh TG
- Wondmieneh AB
- Wool EE
- Wozniak SS
- Wu A-M
- Wu C
- Wu J
- Wunrow HY
- Xie Y
- Xu G
- Xu R
- Yadgir S
- Yamada T
- Yamagishi K
- Yaminfirooz M
- Yano Y
- Yaya S
- Yazdi-Feyzabadi V
- Yearwood JA
- Yeheyis TY
- Yeshitila YG
- Yilgwan CS
- Yilma MT
- Yip P
- Yonemoto N
- Yoon S-J
- York HW
- Younis MZ
- Younker TP
- Yousefi B
- Yousefi Z
- Yousefifard M
- Yousefinezhadi T
- Yousuf AY
- Yu C
- Yu Y
- Yuan C-W
- Yuce D
- Yusefzadeh H
- Zadey S
- Zahabi SS
- Zaidi SS
- Zaki L
- Zaki MES
- Zakzuk J
- Zamani M
- Zamanian M
- Zandian H
- Zangeneh A
- Zarafshan H
- Zastrozhin MS
- Zewdie KA
- Zhang J
- Zhang Y
- Zhang Z-J
- Zhao JT
- Zhao X-JG
- Zhao Y
- Zheleva B
- Zheng P
- Zhou M
- Zhu C
- Ziapour A
- Zimsen SRM
- Zlavog BS
- Zodpey S
- Publication venue
- 'Elsevier BV'
- Publication date
- 17/10/2020
- Field of study
Five insights from the Global Burden of Disease Study 2019
- Author
- Abbafati C
- Abbas KM
- Abbasi M
- Abbasi-Kangevari M
- Abbasifard M
- Abbastabar H
- Abd El Razek HM
- Abd El Razek MM
- Abd-Allah F
- Abdelalim A
- Abdollahi M
- Abdollahpour I
- Abdulkader RS
- Abdullah KH
- Abedi A
- Abedi P
- Abegaz KH
- Abolhassani H
- Abosetugn AE
- Aboyans V
- Abrams EM
- Abreu LG
- Abrigo MRM
- Abu Haimed AK
- Abu-Gharbieh E
- Abu-Raddad LJ
- Abualhasan A
- Abushouk AI
- Acebedo A
- Ackerman IN
- Adabi M
- Adair T
- Adamu AA
- Adebayo OM
- Adedeji IA
- Adekanmbi V
- Adelson JD
- Adeoye AM
- Adetokunboh OO
- Adham D
- Advani SM
- Afarideh M
- Afshari M
- Afshin A
- Agardh EE
- Agarwal G
- Agasthi P
- Agesa KM
- Aghaali M
- Aghamir SMK
- Agrawal A
- Ahmad T
- Ahmadi A
- Ahmadi K
- Ahmadi M
- Ahmadieh H
- Ahmadpour E
- Ahmed MB
- Aji B
- Akalu TY
- Akinyemi RO
- Akinyemiju T
- Akombi B
- Akunna CJ
- Al-Aly Z
- Al-Mekhlafi HM
- Al-Raddadi RM
- Alahdab F
- Alam K
- Alam N
- Alam S
- Alam T
- Alanezi FM
- Alanzi TM
- Albertson SB
- Alcalde-Rabanal JE
- Alema NM
- Alemu BW
- Alemu YM
- Alhabib KF
- Alhassan RK
- Ali M
- Ali S
- Alicandro G
- Alijanzadeh M
- Alinia C
- Alipour V
- Alizade H
- Aljunid SM
- Alla F
- Allebeck P
- Almadi MAH
- Almasi A
- Almasi-Hashiani A
- Almasri NA
- Almulhim AM
- Alonso J
- Altirkawi KA
- Alumran AK
- Alvis-Guzman N
- Alvis-Zakzuk NJ
- Amare AT
- Amare B
- Amini S
- Amini-Rarani M
- Aminorroaya A
- Amiri F
- Amit AML
- Amugsi DA
- Amul GGH
- Anbesu EW
- Ancuceanu R
- Anderlini D
- Anderson JA
- Andrei CL
- Andrei T
- Androudi S
- Angus C
- Anjomshoa M
- Ansari F
- Ansari I
- Ansari-Moghaddam A
- Antonazzo IC
- Antonio CAT
- Antony CM
- Antriyandarti E
- Anvari D
- Anwer R
- Appiah SCY
- Arab-Zozani M
- Arabloo J
- Aravkin AY
- Arba AAK
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- Atre SR
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- Avokpaho EFGA
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- Ayanore MA
- Aynalem GL
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- Azzopardi PS
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- Bagli E
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- Bakhtiari A
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- Balachandran A
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- Baldasseroni A
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- Balzi D
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- Bandpei MAM
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- Banik PC
- Bannick MS
- Bante AB
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- Barboza MA
- Barker-Collo SL
- Barnighausen TW
- Barrero LH
- Barthelemy CM
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- Breusov AV
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- Britton GB
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- Burkart K
- Burnett RT
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- Butt ZA
- Caetano dos Santos FL
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- Castaneda-Orjuela CA
- Castelpietra G
- Castle CD
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- Cercy KM
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- Dahlawi SMA
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- Dai H
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- Dessie GA
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- Dharmaratne SD
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- Dirac MA
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- Do HT
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- Doku DT
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- Dolgert AJ
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- Doshi CP
- Doshi PP
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- Doxey MC
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- Driscoll TR
- Dubljanin E
- Dunachie SJ
- Duncan BB
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- Ebrahimi H
- Edvardsson D
- Effiong A
- Ehrlich JR
- El Nahas N
- El Sayed I
- El Tantawi M
- El-Jaafary SI
- Elbarazi I
- Elgendy IY
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- Elyazar IRF
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- Farahmand M
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- Faro A
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- Fazlzadeh M
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- Feldman R
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- Filip I
- Fischer F
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- Folayan MO
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- Force LM
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- Forooshani ZSD
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- Fukutaki K
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- Gallus S
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- Gardner WM
- Geberemariyam BS
- Gebrehiwot AM
- Gebremedhin KB
- Gebremeskel GG
- Gebremeskel LG
- Gebresillassie BM
- Gebreslassie AAAA
- Gela JD
- Geramo YCD
- Geremew A
- Gesesew HA
- Gething PW
- Gezae KE
- Ghadimi M
- Ghadiri K
- Ghaffarifar F
- Ghafourifard M
- Ghajar A
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- Ghashghaee A
- Ghiasvand H
- Ghith N
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- Gilani SA
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- Jayatilleke AU
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- Publication venue
- Publication date
- 01/01/2020
- Field of study
The Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2019 provides a rules-based synthesis of the available evidence on levels and trends in health outcomes, a diverse set of risk factors, and health system responses. GBD 2019 covered 204 countries and territories, as well as first administrative level disaggregations for 22 countries, from 1990 to 2019. Because GBD is highly standardised and comprehensive, spanning both fatal and non-fatal outcomes, and uses a mutually exclusive and collectively exhaustive list of hierarchical disease and injury causes, the study provides a powerful basis for detailed and broad insights on global health trends and emerging challenges. GBD 2019 incorporates data from 281 586 sources and provides more than 3.5 billion estimates of health outcome and health system measures of interest for global, national, and subnational policy dialogue. All GBD estimates are publicly available and adhere to the Guidelines on Accurate and Transparent Health Estimate Reporting. From this vast amount of information, five key insights that are important for health, social, and economic development strategies have been distilled. These insights are subject to the many limitations outlined in each of the component GBD capstone papers.Peer reviewe
Muon reconstruction and identification efficiency in ATLAS using the full Run 2 pp collision data set at \sqrt{s}=13 TeV
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- Zhemchugov A
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- Publication venue
- 'Springer Fachmedien Wiesbaden GmbH'
- Publication date
- 01/01/2021
- Field of study
This article documents the muon reconstruction and identification efficiency obtained by the ATLAS experiment for 139 \hbox {fb}^{-1} of pp collision data at \sqrt{s}=13 TeV collected between 2015 and 2018 during Run 2 of the LHC. The increased instantaneous luminosity delivered by the LHC over this period required a reoptimisation of the criteria for the identification of prompt muons. Improved and newly developed algorithms were deployed to preserve high muon identification efficiency with a low misidentification rate and good momentum resolution. The availability of large samples of Z\rightarrow \mu \mu and J/\psi \rightarrow \mu \mu decays, and the minimisation of systematic uncertainties, allows the efficiencies of criteria for muon identification, primary vertex association, and isolation to be measured with an accuracy at the per-mille level in the bulk of the phase space, and up to the percent level in complex kinematic configurations. Excellent performance is achieved over a range of transverse momenta from 3 GeV to several hundred GeV, and across the full muon detector acceptance of |\eta |<2.7
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