Structure of TiAlN Reactive Sputtered Coatings

The Raman spectra, X-ray diffraction and hardness of the TiAlN films co-deposited on the steel substrates by reactive sputtering from Ti and Al targets in a mixture of N2 + Ar gas with two magnetrons at room temperature have been studied. From Raman spectra it is found that the position of high-frequency bands in vibrational spectra was located at 700-730 cm 1 or in the region of 830 850 cm 1 depending on the deposition parameters whereas it is not exceed 630 cm 1 from TiAlN of NaCl structure. It is found the two-phase structure of coatings: a small quantity of NaCl-type structure of TiAlN (TiN) and the disordered structure of the chains of polyhedra [TiNx] with x = 5 and x = 4. The chains of polyhedra [TiNx] with x = 4 are mainly formed at large discharge power of Al(Ti) target or at small content of N2 gas. When you are citing the document, use the following link http://essuir.sumdu.edu.ua/handle/123456789/2492

Subcarrier Wave Quantum Key Distribution in Telecommunication Network with Bitrate 800 kbit/s

In the course of work on creating the first quantum communication network in Russia we demonstrated quantum key distribution in metropolitan optical network infrastructure. A single-pass subcarrier wave quantum cryptography scheme was used in the experiments. BB84 protocol with strong reference was chosen for performing key distribution. The registered sifted key rate in an optical cable with 1.5 dB loss was 800 Kbit/s. Signal visibility exceeded 98%, and quantum bit error rate value was 1%. The achieved result is a record for this type of systems

NGS-based identification of druggable alterations and signaling pathways – hepatocellular carcinoma case report

Aim. To identify potential cancer driving or clinically relevant molecular events for a patient with hepatocellular carcinoma. Methods. In order to achieve this goal, we performed RNA-seq and exome sequencing for the tumor tissue and its matched control. We annotated the alterations found using several publicly available databases and bioinformatics tools. Results. We identified several differentially expressed genes linked to the classical sorafenib treatment as well as additional pathways potentially druggable by therapies studied in clinical trials (Erlotinib, Lapatinib and Temsirolimus). Several germline mutations, found in XRCC1, TP53 and DPYD, according to the data from other clinical trials, could be related to the increased sensitivity to platinum therapies and reduced sensitivity to 5-Fluorouracil. We also identified several potentially driving mutations that could not be currently linked to therapies, like deletion in CIRBP, SNVs in BTG1, ERBB3, TCF7L2 et al. Conclusions. The presented study shows the potential usefulness of the integrated approach to the NGS data analysis, including the analysis of germline mutations and transcriptome in addition to the cancer panel or the exome sequencing data.Мета. Ідентифікувати потенційно онкодрайверні або клінічно значущі молекулярні події у пацієнта з гепатоклітинною карциномою. Методи. РНК- та екзомне секвенування пухлинної тканини та відповідного контролю. Анотування знайдених змін, використовуючи декілька загальнодоступних баз даних та біоінформатичних програм. Ми також порівняли транскрипційний профіль досліджуваної пухлини з транскриптомами клітинних ліній з бази даних Genomics of Drug Sensitivity in Cancer. Результати. Ідентифіковано кілька генів, що дифференційно експресуються, і пов’язані як з класичною терапією сорафенібом, так і з додатковими сигнальними шляхами, що потенційно вразливі до терапії препаратами, які досліджувались у клініческих випробуваннях (ерлотініб, лапатініб та темсіролімус). Декілька гермінативних мутацій, знайдених в XRCC1, TP53 та DPYD, згідно з даними інших клінічних випробувань, можуть бути пов’язані з підвищеною чутливістю до платинових терапій та зменшеною чутливістю до 5-фторурацилу. Ми також ідентифікували декілька потенційно драйверних мутацій, які на цей час не можуть бути пов’язані з терапіями, наприклад делеції у CIRBP, заміни в BTG1, ERBB3, TCF7L2 тощо. Висновки. Запропоноване дослідження демонструє потенційну корисність інтегрованого підходу до NGS аналізу даних, в тому числі аналізу гермінативних мутацій та транскриптому у додаток до використання онкологічних генних панелей або даних секвенування екзому.Цель. Выявлении ключевых или клинически значимых молекулярных событий для пациента с гепатоцеллюлярной карциномой. Методы. РНК- и экзомное секвенирования опухолевой и нормальной ткани. Мы проаннотировали найденные генетические нарушения, используя несколько общедоступных баз данных и биоинформатических инструментов. Результаты. Мы определили несколько дифференциально экспрессированных генов, связанных с классической схемой лечения препаратом сорафениб, а также дополнительные пути потенциально поддающиеся терапии препаратами, включенными в клинические испытания (Эрлотиниб, Лапатиниб и Темсиролимус). Несколько герминативных мутаций, найденных в XRCC1, TP53 и DPYD, по данным из других клинических испытаний, могут быть связаны с повышенной чувствительностью к препаратам платины и пониженной чувствительностью к 5-фторурацилу. Мы также определили несколько потенциально драйверных мутаций в генах CIRBP, замены в BTG1, ErbB3, TCF7L2 и др., которые в настоящее время не связаны с тера­пией. Выводы. Данное исследование показывает потенциальную значимость комплексного подхода к анализу данных NGS, в том числе анализа герминативных мутаций и транскриптома в дополнение к данным из генных панелей или секвенирования экзома

Search for a W' boson decaying to a bottom quark and a top quark in pp collisions at sqrt(s) = 7 TeV

Results are presented from a search for a W' boson using a dataset corresponding to 5.0 inverse femtobarns of integrated luminosity collected during 2011 by the CMS experiment at the LHC in pp collisions at sqrt(s)=7 TeV. The W' boson is modeled as a heavy W boson, but different scenarios for the couplings to fermions are considered, involving both left-handed and right-handed chiral projections of the fermions, as well as an arbitrary mixture of the two. The search is performed in the decay channel W' to t b, leading to a final state signature with a single lepton (e, mu), missing transverse energy, and jets, at least one of which is tagged as a b-jet. A W' boson that couples to fermions with the same coupling constant as the W, but to the right-handed rather than left-handed chiral projections, is excluded for masses below 1.85 TeV at the 95% confidence level. For the first time using LHC data, constraints on the W' gauge coupling for a set of left- and right-handed coupling combinations have been placed. These results represent a significant improvement over previously published limits.Comment: Submitted to Physics Letters B. Replaced with version publishe

Search for the standard model Higgs boson decaying into two photons in pp collisions at sqrt(s)=7 TeV

A search for a Higgs boson decaying into two photons is described. The analysis is performed using a dataset recorded by the CMS experiment at the LHC from pp collisions at a centre-of-mass energy of 7 TeV, which corresponds to an integrated luminosity of 4.8 inverse femtobarns. Limits are set on the cross section of the standard model Higgs boson decaying to two photons. The expected exclusion limit at 95% confidence level is between 1.4 and 2.4 times the standard model cross section in the mass range between 110 and 150 GeV. The analysis of the data excludes, at 95% confidence level, the standard model Higgs boson decaying into two photons in the mass range 128 to 132 GeV. The largest excess of events above the expected standard model background is observed for a Higgs boson mass hypothesis of 124 GeV with a local significance of 3.1 sigma. The global significance of observing an excess with a local significance greater than 3.1 sigma anywhere in the search range 110-150 GeV is estimated to be 1.8 sigma. More data are required to ascertain the origin of this excess.Comment: Submitted to Physics Letters

Search for direct production of charginos and neutralinos in events with three leptons and missing transverse momentum in √s = 7 TeV pp collisions with the ATLAS detector

A search for the direct production of charginos and neutralinos in final states with three electrons or muons and missing transverse momentum is presented. The analysis is based on 4.7 fb−1 of proton–proton collision data delivered by the Large Hadron Collider and recorded with the ATLAS detector. Observations are consistent with Standard Model expectations in three signal regions that are either depleted or enriched in Z-boson decays. Upper limits at 95% confidence level are set in R-parity conserving phenomenological minimal supersymmetric models and in simplified models, significantly extending previous results

Jet size dependence of single jet suppression in lead-lead collisions at sqrt(s(NN)) = 2.76 TeV with the ATLAS detector at the LHC

Measurements of inclusive jet suppression in heavy ion collisions at the LHC provide direct sensitivity to the physics of jet quenching. In a sample of lead-lead collisions at sqrt(s) = 2.76 TeV corresponding to an integrated luminosity of approximately 7 inverse microbarns, ATLAS has measured jets with a calorimeter over the pseudorapidity interval |eta| < 2.1 and over the transverse momentum range 38 < pT < 210 GeV. Jets were reconstructed using the anti-kt algorithm with values for the distance parameter that determines the nominal jet radius of R = 0.2, 0.3, 0.4 and 0.5. The centrality dependence of the jet yield is characterized by the jet "central-to-peripheral ratio," Rcp. Jet production is found to be suppressed by approximately a factor of two in the 10% most central collisions relative to peripheral collisions. Rcp varies smoothly with centrality as characterized by the number of participating nucleons. The observed suppression is only weakly dependent on jet radius and transverse momentum. These results provide the first direct measurement of inclusive jet suppression in heavy ion collisions and complement previous measurements of dijet transverse energy imbalance at the LHC.Comment: 15 pages plus author list (30 pages total), 8 figures, 2 tables, submitted to Physics Letters B. All figures including auxiliary figures are available at http://atlas.web.cern.ch/Atlas/GROUPS/PHYSICS/PAPERS/HION-2011-02

Measurement of the polarisation of W bosons produced with large transverse momentum in pp collisions at sqrt(s) = 7 TeV with the ATLAS experiment

This paper describes an analysis of the angular distribution of W->enu and W->munu decays, using data from pp collisions at sqrt(s) = 7 TeV recorded with the ATLAS detector at the LHC in 2010, corresponding to an integrated luminosity of about 35 pb^-1. Using the decay lepton transverse momentum and the missing transverse energy, the W decay angular distribution projected onto the transverse plane is obtained and analysed in terms of helicity fractions f0, fL and fR over two ranges of W transverse momentum (ptw): 35 < ptw < 50 GeV and ptw > 50 GeV. Good agreement is found with theoretical predictions. For ptw > 50 GeV, the values of f0 and fL-fR, averaged over charge and lepton flavour, are measured to be : f0 = 0.127 +/- 0.030 +/- 0.108 and fL-fR = 0.252 +/- 0.017 +/- 0.030, where the first uncertainties are statistical, and the second include all systematic effects.Comment: 19 pages plus author list (34 pages total), 9 figures, 11 tables, revised author list, matches European Journal of Physics C versio