12 research outputs found
Sargramostim to treat patients with acute hypoxic respiratory failure due to COVID-19 (SARPAC) : a structured summary of a study protocol for a randomised controlled trial
- Author
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2020
- Field of study
ObjectivesThe hypothesis of the proposed intervention is that Granulocyte-macrophage colony-stimulating factor (GM-CSF) has profound effects on antiviral immunity, and can provide the stimulus to restore immune homeostasis in the lung with acute lung injury post COVID-19, and can promote lung repair mechanisms, that lead to a 25% improvement in lung oxygenation parameters. Sargramostim is a man-made form of the naturally-occurring protein GM-CSF.Trial designA phase 4 academic, prospective, 2 arm (1:1 ratio), randomized, open-label, controlled trial.ParticipantsPatients aged 18-80 years admitted to specialized COVID-19 wards in 5 Belgian hospitals with recent ( 20 mg methylprednisolone or equivalent), (6) enrolment in another investigational study, (7) pregnant or breastfeeding or (8) ferritin levels > 2000 mu g/mL.Intervention and comparatorInhaled sargramostim 125 mu g twice daily for 5 days in addition to standard care. Upon progression of disease requiring mechanical ventilation or to acute respiratory distress syndrome (ARDS) and initiation of mechanical ventilator support within the 5 day period, inhaled sargramostim will be replaced by intravenous sargramostim 125 mu g/m(2) body surface area once daily until the 5 day period is reached. From day 6 onwards, progressive patients in the active group will have the option to receive an additional 5 days of IV sargramostim, based on the treating physician's assessment. Intervention will be compared to standard of care. Subjects progressing to ARDS and requiring invasive mechanical ventilatory support, from day 6 onwards in the standard of care group will have the option (clinician's decision) to initiate IV sargramostim 125m mu g/m(2) body surface area once daily for 5 days.Main outcomesThe primary endpoint of this intervention is measuring oxygenation after 5 days of inhaled (and intravenous) treatment through assessment of a change in pretreatment and post-treatment ratio of PaO2/FiO(2) and through measurement of the P(A-a)O-2 gradient (PAO(2)= Partial alveolar pressure of oxygen, PaO2=Partial arterial pressure of oxygen; FiO(2)= Fraction of inspired oxygen).RandomisationPatients will be randomized in a 1:1 ratio. Randomization will be done using REDCap (electronic IWRS system).Blinding (masking)In this open-label trial neither participants, caregivers, nor those assessing the outcomes will be blinded to group assignment.Numbers to be randomised (sample size)A total of 80 patients with confirmed COVID-19 and acute hypoxic respiratory failure will be enrolled, 40 in the active and 40 in the control group.Trial StatusSARPAC protocol Version 2.0 (April 15 2020). Participant recruitment is ongoing in 5 Belgian Hospitals (i.e. University Hospital Ghent, AZ Sint-Jan Bruges, AZ Delta Roeselare, University Hospital Brussels and ZNA Middelheim Antwerp). Participant recruitment started on March 26(th) 2020. Given the current decline of the COVID-19 pandemic in Belgium, it is difficult to anticipate the rate of participant recruitment.Trial registrationThe trial was registered on Clinical Trials.gov on March 30(th), 2020 (ClinicalTrials.gov Identifier: NCT04326920) - retrospectively registered; https://clinicaltrials.gov/ct2/show/NCT04326920?term=sarpac&recrs=ab&draw=2&rank=1 and on EudraCT on March 24th, 2020 (Identifier: 2020-001254-22).Full protocolThe full protocol is attached as an additional file, accessible from the Trials website (Additional file 1). In the interest in expediting dissemination of this material, the familiar formatting has been eliminated; this Letter serves as a summary of the key elements of the full protocol
Treatment of severely ill COVID-19 patients with anti-interleukin drugs (COV-AID) : a structured summary of a study protocol for a randomised controlled trial
- Author
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2020
- Field of study
ObjectivesThe purpose of this study is to test the safety and effectiveness of individually or simultaneously blocking IL-6, IL-6 receptor and IL-1 versus standard of care on blood oxygenation and systemic cytokine release syndrome in patients with COVID-19 coronavirus infection and acute hypoxic respiratory failure and systemic cytokine release syndrome.Trial designA phase 3 prospective, multi-center, interventional, open label, 6-arm 2x2 factorial design study.ParticipantsSubjects will be recruited at the specialized COVID-19 wards and/or ICUs at 16 Belgian participating hospitals. Only adult (>= 18y old) patients will be recruited with recent (<= 16 days) COVID-19 infection and acute hypoxia (defined as PaO2/FiO2 below 350mmHg or PaO2/FiO2 below 280 on supplemental oxygen and immediately requiring high flow oxygen device or mechanical ventilation) and signs of systemic cytokine release syndrome characterized by high serum ferritin, or high D-dimers, or high LDH or deep lymphopenia or a combination of those, who have not been on mechanical ventilation for more than 24 hours before randomisation. Patients should have had a chest X-ray and/or CT scan showing bilateral infiltrates within the last 2 days before randomisation. Patients with active bacterial or fungal infection will be excluded.Intervention and comparatorPatients will be randomized to 1 of 5 experimental arms versus usual care. The experimental arms consist of Anakinra alone (anti-IL-1 binding the IL-1 receptor), Siltuximab alone (anti-IL-6 chimeric antibody), a combination of Siltuximab and Anakinra, Tocilizumab alone (humanised anti-IL-6 receptor antibody) or a combination of Anakinra with Tocilizumab in addition to standard care. Patients treated with Anakinra will receive a daily subcutaneous injection of 100mg for a maximum of 28 days or until hospital discharge, whichever comes first. Siltuximab (11mg/kg) or Tocilizumab (8mg/kg, with a maximum dose of 800mg) are administered as a single intravenous injection immediately after randomization.Main outcomesThe primary end point is the time to clinical improvement defined as the time from randomization to either an improvement of two points on a six-category ordinal scale measured daily till day 28 or discharge from the hospital or death. This ordinal scale is composed of (1) Death; (2) Hospitalized, on invasive mechanical ventilation or ECMO; (3) Hospitalized, on non-invasive ventilation or high flow oxygen devices; (4) Hospitalized, requiring supplemental oxygen; (5) Hospitalized, not requiring supplemental oxygen; (6) Not hospitalized.RandomisationPatients will be randomized using an Interactive Web Response System (REDCap). A 2x2 factorial design was selected with a 2:1 randomization regarding the IL-1 blockade (Anakinra) and a 1:2 randomization regarding the IL-6 blockade (Siltuximab and Tocilizumab).Blinding (masking)In this open-label trial neither participants, caregivers, nor those assessing the outcomes are blinded to group assignment.Numbers to be randomised (sample size)A total of 342 participants will be enrolled: 76 patients will receive usual care, 76 patients will receive Siltuximab alone, 76 patients will receive Tocilizumab alone, 38 will receive Anakinra alone, 38 patients will receive Anakinra and Siltuximab and 38 patients will receive Anakinra and Tocilizumab.Trial StatusCOV-AID protocol version 3.0 (15 Apr 2020). Participant recruitment is ongoing and started on April 4(th) 2020. Given the current decline of the COVID-19 pandemic in Belgium, it is difficult to anticipate the rate of participant recruitment.Trial registrationThe trial was registered on Clinical Trials.gov on April 1st, 2020 (ClinicalTrials.gov Identifier: NCT04330638) and on EudraCT on April 3rd 2020 (Identifier: 2020-001500-41).Full protocolThe full protocol is attached as an additional file, accessible from the Trials website (Additional file 1). In the interest in expediting dissemination of this material, the familiar formatting has been eliminated; this Letter serves as a summary of the key elements of the full protocol
Direct Functionalization of (Un)protected Tetrahydroisoquinoline and Isochroman under Iron and Copper Catalysis: Two Metals, Two Mechanisms
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- Abraham C. J.
- Ackermann L.
- Al-Hiari Y. M.
- Alonso E.
- Aubert C.
- Barba-Behrens N.
- Beletskaya I. P.
- Bellina F.
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- Campos K. R.
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- Cheng P.
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- Choi H.
- Choy J.
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- Collamati I.
- Correa A.
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- Daugulis O.
- Davies H. M. L.
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- Marko D. Mihovilovic
- Michael Ghobrial
- Michael Schnürch
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- Murai S.
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- Nakanishi M.
- Negishi E.
- Nicolaou K. C.
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- Pastine S. J.
- Proctor G. R.
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- Scheuermann C. J.
- Scott J. D.
- Sherry B. D.
- Shih K.-C.
- Shilov A. E.
- Shu X.-Z.
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- Thaqi A.
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- Publication venue
- American Chemical Society
- Publication date
- Field of study
Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)
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- Abdelmohsen K.
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- Publication venue
- Publication date
- 22/09/2015
- Field of study
In 2008 we published the first set of guidelines for standardizing research in autophagy. Since then, research on this topic has continued to accelerate, and many new scientists have entered the field. Our knowledge base and relevant new technologies have also been expanding. Accordingly, it is important to update these guidelines for monitoring autophagy in different organisms. Various reviews have described the range of assays that have been used for this purpose. Nevertheless, there continues to be confusion regarding acceptable methods to measure autophagy, especially in multicellular eukaryotes. For example, a key point that needs to be emphasized is that there is a difference between measurements that monitor the numbers or volume of autophagic elements (e.g., autophagosomes or autolysosomes) at any stage of the autophagic process versus those that measure fl ux through the autophagy pathway (i.e., the complete process including the amount and rate of cargo sequestered and degraded). In particular, a block in macroautophagy that results in autophagosome accumulation must be differentiated from stimuli that increase autophagic activity, defi ned as increased autophagy induction coupled with increased delivery to, and degradation within, lysosomes (inmost higher eukaryotes and some protists such as Dictyostelium ) or the vacuole (in plants and fungi). In other words, it is especially important that investigators new to the fi eld understand that the appearance of more autophagosomes does not necessarily equate with more autophagy. In fact, in many cases, autophagosomes accumulate because of a block in trafficking to lysosomes without a concomitant change in autophagosome biogenesis, whereas an increase in autolysosomes may reflect a reduction in degradative activity. It is worth emphasizing here that lysosomal digestion is a stage of autophagy and evaluating its competence is a crucial part of the evaluation of autophagic flux, or complete autophagy. Here, we present a set of guidelines for the selection and interpretation of methods for use by investigators who aim to examine macroautophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes. These guidelines are not meant to be a formulaic set of rules, because the appropriate assays depend in part on the question being asked and the system being used. In addition, we emphasize that no individual assay is guaranteed to be the most appropriate one in every situation, and we strongly recommend the use of multiple assays to monitor autophagy. Along these lines, because of the potential for pleiotropic effects due to blocking autophagy through genetic manipulation it is imperative to delete or knock down more than one autophagy-related gene. In addition, some individual Atg proteins, or groups of proteins, are involved in other cellular pathways so not all Atg proteins can be used as a specific marker for an autophagic process. In these guidelines, we consider these various methods of assessing autophagy and what information can, or cannot, be obtained from them. Finally, by discussing the merits and limits of particular autophagy assays, we hope to encourage technical innovation in the field
Treatment of severely ill COVID-19 patients with anti-interleukin drugs (COV-AID) : a structured summary of a study protocol for a randomised controlled trial (vol 21, 468, 2020)
- Author
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2020
- Field of study
Sargramostim to treat patients with acute hypoxic respiratory failure due to COVID-19 (SARPAC) : a structured summary of a study protocol for a randomised controlled trial (vol 21, 491, 2020)
- Author
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2020
- Field of study
Catecholamine autotoxicity. Implications for pharmacology and therapeutics of Parkinson disease and related disorders
- Author
- Adamczyk
- Adeyemo
- Ahlskog
- Anderson
- Azdad
- Baba
- Barbeau
- Bartl
- Bellia
- Ben-Shachar
- Ben-Shachar
- Berg
- Berman
- Bezard
- Bisaglia
- Bisaglia
- Blanchet
- Blaschko
- Bronstein
- Brown
- Burcham
- Burke
- Burke
- Burke
- Burns
- Burns
- Butcher
- Cai
- Calne
- Cartier
- Casarejos
- Cashaw
- Caudle
- Cavalieri
- Chen
- Chen
- Chiba
- Chu
- Clements
- Colzi
- Cookson
- Corsini
- Cotzias
- Creveling
- Dahlstrom
- Dahlstrom
- Dahlstrom
- David S. Goldstein
- De Iuliis
- de la Fuente-Fernandez
- Decressac
- DeCuypere
- Double
- Ehringer
- Eiden
- Eisenhofer
- Eisenhofer
- Eisenhofer
- Elsworth
- Finberg
- Finberg
- Fitzgerald
- Fitzmaurice
- Fitzmaurice
- Florang
- Fornai
- Fumagalli
- Galter
- Galvin
- Gao
- Gaugler
- Gautam
- German
- Goker-Alpan
- Goldstein
- Goldstein
- Goldstein
- Goldstein
- Goldstein
- Goldstein
- Goldstein
- Goldstein
- Goldstein
- Goldstein
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- Gorell
- Gotz
- Graham
- Grunblatt
- Guillot
- Guillot
- Guo
- Gutteridge
- Hastings
- Hastings
- Hatcher
- Hatcher
- Holford
- Holz
- Hornykiewicz
- Hornykiewicz
- Hornykiewicz
- Hyndman
- Inzelberg
- Irwin J. Kopin
- Jackson
- Jana
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- Jiang
- Jiang
- Jinsmaa
- Jinsmaa
- Jinsmaa
- Johannessen
- Jomova
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- Kagedal
- Kaminskas
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- Kim
- Kish
- Kobayashi
- Kravitz
- Lai
- Lamensdorf
- Lamensdorf
- Larsson
- Lebouvier
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- Mattammal
- Mexas
- Mezey
- Miller
- Miller
- Mittermeyer
- Molochnikov
- Mooslehner
- Mosharov
- Mosharov
- Nagatsu
- Naoi
- Nasstrom
- Navarro-Yepes
- Okamura
- Olanow
- Olanow
- Paik
- Paik
- Panneton
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- Peritore
- Perlmutter
- Polymeropoulos
- Rees
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- Snyder
- Snyder
- Sofic
- Song
- Sossi
- Spillantini
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- Stokes
- Storch
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- Su
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- Tanner
- Taylor
- Taylor
- Tonnesen
- Vasiliou
- Vergo
- Volles
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- Wang
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- Weingarten
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- Yamakawa
- Yao
- Yehonatan Sharabi
- Yoritaka
- Youdim
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- Zheng
- Zhou
- Zigmond
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- Publication venue
- 'Elsevier BV'
- Publication date
- Field of study
Roles of sigma-1 receptors on mitochondrial functions relevant to neurodegenerative diseases
- Author
- A Al-Saif
- A Federico
- A Hyrskyluoto
- A Jana
- A Johri
- A Pal
- A Szabo
- A Szabo
- AA Behensky
- AA Luty
- AE Ruoho
- AE Rusinol
- AF Nicola De
- AI Placido
- AR Vliet van
- AT Dinkova-Kostova
- B Schreiner
- B Uttara
- BA Spruce
- C Cardenas
- C Caspersen
- C Giorgi
- C Guardia-Laguarta
- C He
- C Katnik
- C Merkwirth
- C Vande Velde
- C Wang
- CC Mendes
- CY Liu
- D Crottes
- D Fontanilla
- D Ottolini
- D Ryskamp
- D Sepulveda-Falla
- DD Newmeyer
- DE Copeland
- E Area-Gomez
- E Area-Gomez
- E Barbero-Camps
- E Brouillet
- E Junn
- E Zampese
- F Langa
- F Palmieri
- F Squitieri
- FC Kauffman
- G Csordas
- GM Borthwick
- H Deng
- H Dong
- H Tagashira
- H Tagashira
- H Wang
- HM Wilkins
- HR Schmidt
- IE Clark
- J Deng
- J Kong
- J Lee
- J Magrane
- J Meunier
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- J Park
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- J Sun
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- JM Schrock
- JP Decuypere
- JT Vollrath
- JW Taanman
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- K Ruscher
- K Shen
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- KT Tchedre
- L Cao
- L Devi
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- L Hedskog
- L Nguyen
- L Nguyen
- L Romero
- L Ruan
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- L Wang
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- LJ Siskind
- LY Hao
- M Achison
- M Fujimoto
- M Geva
- M Hamasaki
- M Manczak
- M Manczak
- M Mishina
- M Neumann
- M Prasad
- MC Gonzalez Deniselle
- MC Kiernan
- MD Tambini
- MP Murphy
- MR Duchen
- MS Parihar
- MT Lin
- N Bernard-Marissal
- N Natsvlishvili
- N Shioda
- O Kann
- P Mishra
- R Bravo
- R Bravo
- R Kasahara
- R Lopez-Gonzalez
- R Rizzuto
- R Rizzuto
- R Stoica
- RA Quintanilla
- RA Roos
- RJ Youle
- RW Irwin
- S Cory
- S Geisler
- S Naghdi
- S Paillusson
- S Paillusson
- S Ramachandran
- S Reijonen
- S Sha
- S Srivats
- S Watanabe
- S Yang
- SD Yan
- Shang-Yi Anne Tsai
- SJ Stone
- SR Maurya
- SY Tsai
- SY Tsai
- SY Tsai
- SY Tsai
- SY Tsai
- T Cali
- T Cali
- T Hayashi
- T Hayashi
- T Hayashi
- T Hayashi
- T Hayashi
- T Hayashi
- T Hayashi
- T Higo
- T Maurice
- T Mitsuda
- T Mori
- T Mori
- T Omi
- T Schmitt
- TA Mavlyutov
- TA Mavlyutov
- TC Su
- TD MacVicar
- TP Su
- TP Su
- TP Su
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- Tsung-Ping Su
- Tzu-Yu Weng
- UP Shirendeb
- V Carelli
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- X Wang
- XL Zhao
- Y Ha
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- YC Wong
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- Z Wang
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- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Erratum to: Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) (Autophagy, 12, 1, 1-222, 10.1080/15548627.2015.1100356
- Author
- Abdelmohsen Kotb
- Abe Akihisa
- Abedin Md Joynal
- Abeliovich Hagai
- Adachi Hiroaki
- Adams Christopher M.
- Adams Peter D.
- Adeli Khosrow
- Adhihetty Peter J.
- Adler Sharon G.
- Agam Galila
- Agarwal Rajesh
- Aghi Manish K.
- Agnello Maria
- Agostinis Patrizia
- Aguilar Patricia V.
- Aguirre-Ghiso Julio
- Airoldi Edoardo M.
- Ait-Si-Ali Slimane
- Akematsu Takahiko
- Akporiaye Emmanuel T.
- Al-Rubeai Mohamed
- Albaiceta Guillermo M.
- Albanese Chris
- Albani Diego
- Albert Matthew L.
- Aldudo Jesus
- Algül Hana
- Alirezaei Mehrdad
- Alloza Iraide
- Almasan Alexandru
- Almonte-Beceril Maylin
- Alnemri Emad S.
- Alonso Covadonga
- Altan-Bonnet Nihal
- Altieri Dario C.
- Alvarez Silvia
- Alvarez-Erviti Lydia
- Alves Sandro
- Amadoro Giuseppina
- Amano Atsuo
- Amantini Consuelo
- Ambrosio Santiago
- Amelio Ivano
- Amer Amal O.
- Amessou Mohamed
- Amon Angelika
- An Zhenyi
- Anania Frank A.
- Andersen Stig U.
- Andley Usha P.
- Andreadi Catherine K.
- Andrieu-Abadie Nathalie
- Anel Alberto
- Ann David K.
- Anoopkumar-Dukie Shailendra
- Antonioli Manuela
- Aoki Hiroshi
- Apostolova Nadezda
- Aquila Saveria
- Aquilano Katia
- Araki Koichi
- Arama Eli
- Aranda Agustin
- Araya Jun
- Arcaro Alexandre
- Arias Esperanza
- Arimoto Hirokazu
- Ariosa Aileen R.
- Armstrong Jane L.
- Arnould Thierry
- Arozena Abraham Acevedo
- Arsov Ivica
- Asanuma Katsuhiko
- Askanas Valerie
- Asselin Eric
- Atarashi Ryuichiro
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- Atkin Julie D.
- Attardi Laura D.
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- Auburger Georg
- Aurelian Laure
- Autelli Riccardo
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- Avrahami Limor
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- Azad Neelam
- Bachetti Tiziana
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- Bae Dong-Hun
- Bae Jae-Sung
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- Bae Soo Han
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- Bagniewska-Zadworna Agnieszka
- Bai Hua
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- Bai Xue-Yuan
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- Balaji Kithiganahalli Narayanaswamy
- Balduini Walter
- Ballabio Andrea
- Balzan Rena
- Banerjee Rajkumar
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- Beaulieu Jean-François
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- Bejarano Eloy
- Belaid Amine
- Belleudi Francesca
- Berchem Guy
- Bergamaschi Daniele
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- Bernassola Francesca
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- Bettuzzi Saverio
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- Böckler Stefan
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- Cai Dongsheng
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- Cavallini Gabriella
- Ceccherini Isabella
- Cecconi Francesco
- Cederbaum Arthur I.
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- Cervia Davide
- Cetrullo Silvia
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- Chai Chee-Yin
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- Chen Ye-Guang
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- Chen Yongshun
- Chen Yu-Jen
- Chen Yue-Qin
- Chen Yujie
- Chen Zhen
- Chen Zhong
- Cheng Alan
- Cheng Christopher H. K.
- Cheng Hua
- Cheong Heesun
- Cherry Sara
- Chesney Jason
- Cheung Chun Hei Antonio
- Chevet Eric
- Chi Hsiang Cheng
- Chi Sung-Gil
- Chiacchiera Fulvio
- Chiang Hui-Ling
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- Chiariello Mario
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- Chou Tsui-Fen
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- Choubey Divaker
- Choubey Vinay
- Chow Kuan-Chih
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- Chuang Tsung-Hsien
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- Chung Hyewon
- Chung Taijoon
- Chung Yuen-Li
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- Ciarcia Roberto
- Ciechomska Iwona A.
- Ciriolo Maria Rosa
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- Clementi Emilio
- Cleyrat Cédric
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- Yao Xiaofeng
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- Yasui Linda S.
- Ye Mingxiang
- Yedvobnick Barry
- Yeganeh Behzad
- Yeh Elizabeth S.
- Yeyati Patricia L.
- Yi Fan
- Yi Long
- Yin Xiao-Ming
- Yip Calvin K.
- Yoo Yeong-Min
- Yoo Young Hyun
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- Yoshida Ken-Ichi
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- Yue Jianbo
- Yue Zhenyu
- Zacks David N.
- Zacksenhaus Eldad
- Zaffaroni Nadia
- Zaglia Tania
- Zakeri Zahra
- Zecchini Vincent
- Zeng Jinsheng
- Zeng Min
- Zeng Qi
- Zervos Antonis S.
- Zhang Donna D.
- Zhang Fan
- Zhang Guo
- Zhang Guo-Chang
- Zhang Hao
- Zhang Hong
- Zhang Hongbing
- Zhang Jian
- Zhang Jiangwei
- Zhang Jianhua
- Zhang Jing-Pu
- Zhang Li
- Zhang Lin
- Zhang Long
- Zhang Ming-Yong
- Zhang Xiangnan
- Zhang Xu Dong
- Zhang Yan
- Zhang Yang
- Zhang Yanjin
- Zhang Yingmei
- Zhang Yunjiao
- Zhao Mei
- Zhao Wei-Li
- Zhao Xiaonan
- Zhao Yan G.
- Zhao Ying
- Zhao Yongchao
- Zhao Yu-Xia
- Zhao Zhendong
- Zhao Zhizhuang J.
- Zheng Dexian
- Zheng Xi-Long
- Zheng Xiaoxiang
- Zhivotovsky Boris
- Zhong Qing
- Zhou Guang-Zhou
- Zhou Guofei
- Zhou Huiping
- Zhou Shu-Feng
- Zhou Xu-Jie
- Zhu Hongxin
- Zhu Hua
- Zhu Wei-Guo
- Zhu Wenhua
- Zhu Xiao-Feng
- Zhu Yuhua
- Zhuang Shi-Mei
- Zhuang Xiaohong
- Ziparo Elio
- Zois Christos E.
- Zoladek Teresa
- Zong Wei-Xing
- Zorzano Antonio
- Zughaier Susu M.
- Publication venue
- 'Informa UK Limited'
- Publication date
- 01/01/2016
- Field of study
non present
Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)
- Author
- Abdelmohsen Kotb
- Abe Akihisa
- Abedin Md Joynal
- Abeliovich Hagai
- Adachi Hiroaki
- Adams Christopher M.
- Adams Peter D.
- Adeli Khosrow
- Adhihetty Peter J.
- Adler Sharon G.
- Agam Galila
- Agarwal Rajesh
- Aghi Manish K.
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- Jiang Xuejun
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- Stellrecht Christine M.
- Stenmark Harald
- Stepkowski Tomasz M.
- Stern Stephan T.
- Stevens Craig
- Stockwell Brent R.
- Stoka Veronika
- Storchova Zuzana
- Stork Bjoern
- Stratoulias Vassilis
- Stravopodis Dimitrios J.
- Strnad Pavel
- Stroem Anna-Lena
- Strohecker Anne Marie
- Stromhaug Per
- Stulik Jiri
- Su Yu-Xiong
- Su Zhaoliang
- Subauste Carlos S.
- Subramaniam Srinivasa
- Sue Carolyn M.
- Suh Sang Won
- Sui Xinbing
- Sukseree Supawadee
- Sulzer David
- Sun Fang-Lin
- Sun Jiaren
- Sun Jun
- Sun Shi-Yong
- Sun Yang
- Sun Yi
- Sun Yingjie
- Sundaramoorthy Vinod
- Sung Joseph
- Suzuki Hidekazu
- Suzuki Kuninori
- Suzuki Naoki
- Suzuki Tadashi
- Suzuki Yuichiro J.
- Swaerd Karl
- Swanson Michele S.
- Swanton Charles
- Swarup Ghanshyam
- Sweeney Sean T.
- Sylvester Paul W.
- Szatmari Zsuzsanna
- Szegezdi Eva
- Szlosarek Peter W.
- Taegtmeyer Heinrich
- Tafani Marco
- Taillebourg Emmanuel
- Tait Stephen W. G.
- Takacs-Vellai Krisztina
- Takahashi Yoshinori
- Takats Szabolcs
- Takemura Genzou
- Takigawa Nagio
- Talbot Nicholas J.
- Tamagno Elena
- Tamburini Jerome
- Tan Cai-Ping
- Tan Lan
- Tan Mei Lan
- Tan Ming
- Tan Yee-Joo
- Tanaka Keiji
- Tanaka Masaki
- Tang Daolin
- Tang Dingzhong
- Tang Guomei
- Tanida Isei
- Tanji Kunikazu
- Tannous Bakhos A.
- Tapia Jose A.
- Tasset-Cuevas Inmaculada
- Tatar Marc
- Tavassoly Iman
- Tavernarakis Nektarios
- Taylor Allen
- Taylor Graham S.
- Taylor Gregory A.
- Taylor J. Paul
- Taylor Mark J.
- Tchetina Elena V.
- Tee Andrew R.
- Teixeira-Clerc Fatima
- Telang Sucheta
- Tencomnao Tewin
- Teng Ba-Bie
- Teng Ru-Jeng
- Tenorio de Melo Edesio Jose
- Terro Faraj
- Tettamanti Gianluca
- Theiss Arianne L.
- Theron Anne E.
- Thomas Kelly Jean
- Thome Marcos P.
- Thomes Paul G.
- Thorburn Andrew
- Thorner Jeremy
- Thum Thomas
- Thumm Michael
- Thurston Teresa L. M.
- Tian Ling
- Till Andreas
- Ting Jenny Pan-yun
- Titorenko Vladimir I.
- Toker Lilach
- Toldo Stefano
- Tooze Sharon A.
- Topisirovic Ivan
- Torgersen Maria Lyngaas
- Torosantucci Liliana
- Torriglia Alicia
- Torrisi Maria Rosaria
- Tournier Cathy
- Towns Roberto
- Trajkovic Vladimir
- Travassos Leonardo H.
- Triola Gemma
- Tripathi Durga Nand
- Trisciuoglio Daniela
- Troncoso Rodrigo
- Trougakos Ioannis P.
- Truttmann Anita C.
- Tsai Kuen-Jer
- Tschan Mario P.
- Tseng Yi-Hsin
- Tsukuba Takayuki
- Tsung Allan
- Tsvetkov Andrey S.
- Tu Shuiping
- Tuan Hsing-Yu
- Tucci Marco
- Tumbarello David A.
- Turk Boris
- Turk Vito
- Turner Robin F. B.
- Tveita Anders A.
- Tyagi Suresh C.
- Ubukata Makoto
- Uchiyama Yasuo
- Udelnow Andrej
- Ueno Takashi
- Umekawa Midori
- Umemiya-Shirafuji Rika
- Underwood Benjamin R.
- Ungermann Christian
- Ureshino Rodrigo P.
- Ushioda Ryo
- Uversky Vladimir N.
- Uzcategui Nestor L.
- Vaccari Thomas
- Vaccaro Maria I.
- Vachova Libuse
- Vakifahmetoglu-Norberg Helin
- Valdor Rut
- Valente Enza Maria
- Valle Luisa Dalla
- Vallette Francois
- Valverde Angela M.
- van Campagne Menno Lookeren
- Van den Berghe Greet
- Van Den Bosch Ludo
- van den Brink Gijs R.
- van der Goot F. Gisou
- van der Klei Ida J.
- van der Laan Luc J. W.
- van Doorn Wouter G.
- van Egmond Marjolein
- van Golen Kenneth L.
- Van Kaer Luc
- Vandenabeele Peter
- Vandenberghe Wim
- Vanhorebeek Ilse
- Varela-Nieto Isabel
- Vasconcelos M. Helena
- Vasko Radovan
- Vavvas Demetrios G.
- Vega-Naredo Ignacio
- Velasco Guillermo
- Velentzas Athanassios D.
- Velentzas Panagiotis D.
- Vellai Tibor
- Vellenga Edo
- Vendelbo Mikkel Holm
- Venkatachalam Kartik
- Ventura Natascia
- Ventura Salvador
- Veras Patricia S. T.
- Verdier Mireille
- Vertessy Beata G.
- Vescovi Eleonora Garcia
- Viale Andrea
- Vidal Michel
- Vieira Helena L. A.
- Vierstra Richard D.
- Vigneswaran Nadarajah
- Vij Neeraj
- Vila Miquel
- Villar Margarita
- Villar Victor H.
- Villarroya Joan
- Vindis Cecile
- Viola Giampietro
- Viscomi Maria Teresa
- Vitale Giovanni
- Vogl Dan T.
- Voitsekhovskaja Olga V.
- von Haefen Clarissa
- von Schwarzenberg Karin
- Voth Daniel E.
- Vouret-Craviari Valerie
- Vuori Kristina
- Vyas Jatin M.
- Waeber Christian
- Walker Cheryl Lyn
- Walker Mark J.
- Walter Jochen
- Wan Lei
- Wan Xiangbo
- Wang Bo
- Wang Caihong
- Wang Chao-Yung
- Wang Chengshu
- Wang Chenran
- Wang Chuangui
- Wang Dong
- Wang Fen
- Wang Fuxin
- Wang Guanghui
- Wang Hai-jie
- Wang Haichao
- Wang Hong-Gang
- Wang Hongmin
- Wang Horng-Dar
- Wang Jing
- Wang Junjun
- Wang Mei
- Wang Mei-Qing
- Wang Pei-Yu
- Wang Peng
- Wang Richard C.
- Wang Shuo
- Wang Ting-Fang
- Wang Xian
- Wang Xiao-jia
- Wang Xiao-Wei
- Wang Xin
- Wang Xuejun
- Wang Yan
- Wang Yanming
- Wang Ying
- Wang Ying-Jan
- Wang Yipeng
- Wang Yu
- Wang Yu Tian
- Wang Yuqing
- Wang Zhi-Nong
- Wappner Pablo
- Ward Carl
- Ward Diane Mcvey
- Warnes Gary
- Watada Hirotaka
- Watanabe Yoshihisa
- Watase Kei
- Weaver Timothy E.
- Weekes Colin D.
- Wei Jiwu
- Weide Thomas
- Weihl Conrad C.
- Weindl Guenther
- Weis Simone Nardin
- Wen Longping
- Wen Xin
- Wen Yunfei
- Westermann Benedikt
- Weyand Cornelia M.
- White Anthony R.
- White Eileen
- Whitton J. Lindsay
- Whitworth Alexander J.
- Wiels Joelle
- Wild Franziska
- Wildenberg Manon E.
- Wileman Tom
- Wilkinson Deepti Srinivas
- Wilkinson Simon
- Willbold Dieter
- Williams Chris
- Williams Katherine
- Williamson Peter R.
- Winklhofer Konstanze F.
- Witkin Steven S.
- Wohlgemuth Stephanie E.
- Wollert Thomas
- Wolvetang Ernst J.
- Wong Esther
- Wong G. William
- Wong Richard W.
- Wong Vincent Kam Wai
- Woodcock Elizabeth A.
- Wright Karen L.
- Wu Chunlai
- Wu Defeng
- Wu Gen Sheng
- Wu Jian
- Wu Junfang
- Wu Mian
- Wu Min
- Wu Shengzhou
- Wu William K. K.
- Wu Yaohua
- Wu Zhenlong
- Xavier Cristina P. R.
- Xavier Ramnik J.
- Xia Gui-Xian
- Xia Tian
- Xia Weiliang
- Xia Yong
- Xiao Hengyi
- Xiao Jian
- Xiao Shi
- Xiao Wuhan
- Xie Chuan-Ming
- Xie Zhiping
- Xie Zhonglin
- Xilouri Maria
- Xiong Yuyan
- Xu Chuanshan
- Xu Congfeng
- Xu Feng
- Xu Haoxing
- Xu Hongwei
- Xu Jian
- Xu Jianzhen
- Xu Jinxian
- Xu Liang
- Xu Xiaolei
- Xu Yangqing
- Xu Ye
- Xu Zhi-Xiang
- Xu Ziheng
- Xue Yu
- Yamada Takahiro
- Yamamoto Ai
- Yamanaka Koji
- Yamashina Shunhei
- Yamashiro Shigeko
- Yan Bing
- Yan Bo
- Yan Xianghua
- Yan Zhen
- Yanagi Yasuo
- Yang Dun-Sheng
- Yang Jin-Ming
- Yang Liu
- Yang Minghua
- Yang Pei-Ming
- Yang Peixin
- Yang Qian
- Yang Wannian
- Yang Wei Yuan
- Yang Xuesong
- Yang Yi
- Yang Ying
- Yang Zhifen
- Yang Zhihong
- Yao Meng-Chao
- Yao Pamela J.
- Yao Xiaofeng
- Yao Zhenyu
- Yao Zhiyuan
- Yasui Linda S.
- Ye Mingxiang
- Yedvobnick Barry
- Yeganeh Behzad
- Yeh Elizabeth S.
- Yeyati Patricia L.
- Yi Fan
- Yi Long
- Yin Xiao-Ming
- Yip Calvin K.
- Yoo Yeong-Min
- Yoo Young Hyun
- Yoon Seung-Yong
- Yoshida Ken-Ichi
- Yoshimori Tamotsu
- Young Ken H.
- Yu Huixin
- Yu Jane J.
- Yu Jin-Tai
- Yu Jun
- Yu Li
- Yu W. Haung
- Yu Xiao-Fang
- Yu Zhengping
- Yuan Junying
- Yuan Zhi-Min
- Yue Beatrice Y. J. T.
- Yue Jianbo
- Yue Zhenyu
- Zacks David N.
- Zacksenhaus Eldad
- Zaffaroni Nadia
- Zaglia Tania
- Zakeri Zahra
- Zecchini Vincent
- Zeng Jinsheng
- Zeng Min
- Zeng Qi
- Zervos Antonis S.
- Zhang Donna D.
- Zhang Fan
- Zhang Guo
- Zhang Guo-Chang
- Zhang Hao
- Zhang Hong
- Zhang Hong
- Zhang Hongbing
- Zhang Jian
- Zhang Jian
- Zhang Jiangwei
- Zhang Jianhua
- Zhang Jing-pu
- Zhang Li
- Zhang Lin
- Zhang Lin
- Zhang Long
- Zhang Ming-Yong
- Zhang Xiangnan
- Zhang Xu Dong
- Zhang Yan
- Zhang Yang
- Zhang Yanjin
- Zhang Yingmei
- Zhang Yunjiao
- Zhao Mei
- Zhao Wei-Li
- Zhao Xiaonan
- Zhao Yan G.
- Zhao Ying
- Zhao Yongchao
- Zhao Yu-Xia
- Zhao Zhendong
- Zhao Zhizhuang J.
- Zheng Dexian
- Zheng Xi-Long
- Zheng Xiaoxiang
- Zhivotovsky Boris
- Zhong Qing
- Zhou Guang-Zhou
- Zhou Guofei
- Zhou Huiping
- Zhou Shu-Feng
- Zhou Xu-Jie
- Zhu Hongxin
- Zhu Hua
- Zhu Wei-Guo
- Zhu Wenhua
- Zhu Xiao-Feng
- Zhu Yuhua
- Zhuang Shi-Mei
- Zhuang Xiaohong
- Ziparo Elio
- Zois Christos E.
- Zoladek Teresa
- Zong Wei-Xing
- Zorzano Antonio
- Zughaier Susu M.
- Publication venue
- Publication date
- 01/01/2016
- Field of study