El sistema de control interno y su influencia en la gestión económica y financiera de la Municipalidad Distrital de el Porvenir, Provincia de Trujillo, año 2016

La invest igación tuvo como objetivo determinar como el Sistema del Control Interno influye en la gestión económica y financiera de la Municipalidad Distrital de El Porvenir, provincia de Trujillo, año 2016, comprende el desarrollo progresivo de las diferentes etapas que intervienen desde la recopilación bibliográfica, revisión de documentos del pliego presupuestal, el procesamiento de los datos obtenidos en campo, elaboración y análisis de los resultados que permiten integrar todas las variables de acuerdo al problema. Desde el punto de vista metodológico, adquirió un enfoque cuantitativo, con un diseño explicativo o causal, mediant e el cual se investigó las causas y efectos, así como la relación de las variables, y en qué circunstancias se desarrolló la situación en estudio. En recolección de datos, se empleó la técnica de la encuesta, observación y análisis documental, siendo los instrumentos la guía de observación, guía de análisis documental y cuestionario. Mediante el estudio realizado determinamos que existe insensibilización del personal con respecto a la aplicación de las normativas del sistema de control, la inexistencia de evaluación de riesgos, el desconocimiento de procedimientos y requisitos para realizar las operaciones, la falta de información y comunicación de una manera oportuna y fluida; todo ello origina que el Sistema de Control Interno sea deficiente, generando una gestión económica y financiera insuficiente en la Municipalidad Distrital de El Porvenir poniendo en riesgo a la gestión municipal.The research aimed to determine how the Internal Control System influences the economic and financial management of the Municipality of El Porvenir, Trujillo province, in 2016, comprises the progressive development of the different stages involved from the collection of the bibliography, review Of documents of the budget statement, the processing of the data obtained in the field, elaboration and analysis of the results that allow to integrate all the variables according to the problem. From the methodological point of view, it acquired a quantitative approach, with an explanatory or causal design, through which the causes and effects were investigated, as well as the relation of the variables, and under what circumstances the situation under study was developed. In data collection, the technique of survey, observation and documentary analysis was used, the instruments being the observation guide, documentary analysis guide and questionnaire. Through the study carried out we determined that there is a numbing of personnel regarding the application of the regulations of the control system, the lack of risk assessment, the lack of procedures and requirements to perform operations, lack of information and communication in a way Timely and fluid; All this causes that the Internal Control System is deficient, generating an insufficient economic and financial management in the Municipality of El Porvenir putting in risk to the municipal management

El efecto de la Roya y la exportación del café hacia China, 2017- 2021

El café peruano es un producto que muestra una gran importancia dentro de la economía del país, por lo que tener un buen cuidado dependerá de los manejos agronómicos adecuados a la plantación, las elecciones de los fungicidas y su correcta aplicación en el momento oportuno. El problema de investigación fue: ¿Cuál es la relación que existe entre el efecto de la roya y la exportación del café hacia China, 2017 - 2021?, con el objetivo de Determinar la relación que existe entre el efecto de la roya y la exportación del café hacia China, 2017 - 2021. Asimismo, la investigación fue de tipo aplicada de un diseño no experimental, transversal y descriptivo. Asimismo, es explicativa, longitudinal y documental. Por otro lado, la investigación fue realizada por medio de tablas de criterio, en donde se analizó cómo interpretó en el tiempo comparando eventos durante el año 2017 al 2021, la cual nos ayudaron a responder los objetivos planteados sobre el efecto de la roya y de la exportación del café. De esta forma, que, de acuerdo a los datos históricos de la información determinada, se concluye que, si existe una gran relación significativa entre el efecto de la roya y la exportación del café hacia China, 2017 - 2021

Síntesis de TiO2: Efecto de las variables de síntesis en la actividad fotocatalítica

Las propiedades fotocatalíticas del óxido de titanio sintetizado por la técnica sol-gel, fueron evaluadas en la reacción fotoasistida de degradación de un colorante artificial (tartrazina). Se estudió el efecto del orden de agregado de los reactivos en la síntesis: 1_ medio hidrolizante acidulado con ac. 4- hidroxibenzoico sobre el precursor de Ti y 2_ precursor de Ti sobre el medio hidrolizante acidulado con ac. 4-hidroxibenzoico . Los sólidos fueron calcinados a 300, 500 y 700 ºC. y fueron caracterizadas por análisis térmico diferencial, difracción de rayos X y microscopía electrónica. El estudio de la influencia del orden de agregado de los reactivos y el tratamiento térmico sobre el comportamiento catalítico de los sólidos obtenidos, muestra que la mejor actividad catalítica se obtiene agregando el medio hidrolizante acidulado sobre el precursor y calcinando a 500 ºC. La explicación para esta reactividad puede atribuirse a las especies formadas inicialmente, que influyen en las reacciones de policondensación secundarias, que a su vez afectan la morfología y la estructura cristalina de los sólidos resultantes.The photocatalytic properties of titanium oxide synthesized by sol - gel, were evaluated in the photo assisted reaction of an artificial dye’s (tartrazine) degradation. The reagent’s order of addition effect in the synthesis was studied: 1_ hydrolyzing medium on precursor and 2_ precursor on the hydrolyzing medium. Solids were calcined at 300, 500 and 700 °C and were characterized by differential thermal analysis, X-ray diffraction and electronic microscopy. The study on the influence of reagent’s order of addition and thermal treatment on the catalytic behavior of the solid, show that the best catalytic activity is obtained by adding the hydrolyzing medium on the precursor and calcining at 500 ° C. The explanation to this reactivity can be attributed to the species formed initially which have an influence on the secondary polycondensation reactions, which in turn affect morphology and the crystal structure of the resulting solids.Fil: Cornejo, Rosario. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Salta. Instituto de Investigaciones para la Industria Química. Universidad Nacional de Salta. Facultad de Ingeniería. Instituto de Investigaciones para la Industria Química; Argentina. Universidad Nacional de Salta. Facultad de Ingeniería; ArgentinaFil: Farfan Torres, Elsa Monica. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Salta. Instituto de Investigaciones para la Industria Química. Universidad Nacional de Salta. Facultad de Ingeniería. Instituto de Investigaciones para la Industria Química; Argentina. Universidad Nacional de Salta. Facultad de Ciencias Exactas; ArgentinaFil: Sham, Edgardo Ling. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Salta. Instituto de Investigaciones para la Industria Química. Universidad Nacional de Salta. Facultad de Ingeniería. Instituto de Investigaciones para la Industria Química; Argentina. Universidad Nacional de Salta. Facultad de Ingeniería; Argentin

The Role of Limited English Proficiency and Access to Health Insurance and Health Care in the Affordable Care Act Era

Purpose: Limited English proficiency adversely impacts people\u27s ability to access health services. This study examines the association between English language proficiency and insurance access and use of a usual care provider after the implementation of the Affordable Care Act (ACA). Methods: Using cross-sectional data from the 2016 Medical Panel Expenditures Survey, we identified 24,099 adults (weighted n=240,035,048) and categorized them by self-reported English-language proficiency. We classified participants according to responses to: How well do you speak English? Would you say... Very well; well; Not well; Not at all? (having limited English proficiency: not well; not at all, English proficient: well; very well; and English only: not applicable) and What language do you speak at home? Would you say... English, Spanish, Other. Using these two recoded variables, we created a variable with five categories: (1) Spanish speaking, with limited English proficiency, (2) other language speaking, with limited English proficiency, (3) Spanish speaking, English proficient, (4) other language speaking, English proficient, and (5) English only. Health insurance and usual care provider were determined by self-report. Results: Among those \u3c 65 years, the percent covered by public insurance (Spanish: 21%, Other languages: 28%, English only 14%), who were uninsured (Spanish: 46%, Other languages: 17%, English only: 8%), and who lacked a usual care provider (Spanish: 45%, Other languages: 35%, English only: 26%) differed by English language proficiency. Among those \u3e /=65 years, fewer people with limited English proficiency relative to English only were dually covered by Medicare and private insurance (Spanish: 12%, Other languages: 15%, English only: 59%), and a higher percent lacked a usual care provider (Spanish: 15%, Other languages: 11%, English only: 7%). Differences persisted with adjustment for covariates. Conclusion: Post the ACA, persons with limited English proficiency remain at a risk of being uninsured relative to those who only speak English

La “ideología de género” frente a los derechos sexuales y reproductivos. El escenario español

Se analiza el caso español como laboratorio europeo en el que se han ensayado las estrategias de movilización basadas en el discurso de la “ideología de género” contra los derechos sexuales y de las mujeres por parte de actores ultraconservadores, con especial atención a los actores católicos. Se presentan cuatro momentos: el discurso de la Iglesia Católica, como fuente originaria del lenguaje de este nuevo pánico moral; las reformas legales progresistas que detonan el ciclo de protesta; la contestación social de los grupos conservadores y la posterior reacción conservadora moderada desde la acción de gobierno

Habemus gender! Déconstruction d'une riposte religieuse

Depuis 2012, les mobilisations françaises contre l’ouverture du mariage et de l’adoption aux unions de même sexe ont défrayé la chronique, tant en France qu’à l’étranger. Celles-ci ont révélé l’existence d’un mouvement sans précédent, dont l’agenda dépasse largement la reconnaissance des droits des homosexuel.le.s

Embracing monogenic Parkinson's disease: the MJFF Global Genetic PD Cohort

© 2023 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.Background: As gene-targeted therapies are increasingly being developed for Parkinson's disease (PD), identifying and characterizing carriers of specific genetic pathogenic variants is imperative. Only a small fraction of the estimated number of subjects with monogenic PD worldwide are currently represented in the literature and availability of clinical data and clinical trial-ready cohorts is limited. Objective: The objectives are to (1) establish an international cohort of affected and unaffected individuals with PD-linked variants; (2) provide harmonized and quality-controlled clinical characterization data for each included individual; and (3) further promote collaboration of researchers in the field of monogenic PD. Methods: We conducted a worldwide, systematic online survey to collect individual-level data on individuals with PD-linked variants in SNCA, LRRK2, VPS35, PRKN, PINK1, DJ-1, as well as selected pathogenic and risk variants in GBA and corresponding demographic, clinical, and genetic data. All registered cases underwent thorough quality checks, and pathogenicity scoring of the variants and genotype-phenotype relationships were analyzed. Results: We collected 3888 variant carriers for our analyses, reported by 92 centers (42 countries) worldwide. Of the included individuals, 3185 had a diagnosis of PD (ie, 1306 LRRK2, 115 SNCA, 23 VPS35, 429 PRKN, 75 PINK1, 13 DJ-1, and 1224 GBA) and 703 were unaffected (ie, 328 LRRK2, 32 SNCA, 3 VPS35, 1 PRKN, 1 PINK1, and 338 GBA). In total, we identified 269 different pathogenic variants; 1322 individuals in our cohort (34%) were indicated as not previously published. Conclusions: Within the MJFF Global Genetic PD Study Group, we (1) established the largest international cohort of affected and unaffected individuals carrying PD-linked variants; (2) provide harmonized and quality-controlled clinical and genetic data for each included individual; (3) promote collaboration in the field of genetic PD with a view toward clinical and genetic stratification of patients for gene-targeted clinical trials. © 2023 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.Michael J. Fox Foundation for Parkinson's Research. Grant Number: ID 15015.02. NIHR Cambridge Biomedical Research Centre. Grant Number: BRC-1215-20014info:eu-repo/semantics/publishedVersio

Large expert-curated database for benchmarking document similarity detection in biomedical literature search

Document recommendation systems for locating relevant literature have mostly relied on methods developed a decade ago. This is largely due to the lack of a large offline gold-standard benchmark of relevant documents that cover a variety of research fields such that newly developed literature search techniques can be compared, improved and translated into practice. To overcome this bottleneck, we have established the RElevant LIterature SearcH consortium consisting of more than 1500 scientists from 84 countries, who have collectively annotated the relevance of over 180 000 PubMed-listed articles with regard to their respective seed (input) article/s. The majority of annotations were contributed by highly experienced, original authors of the seed articles. The collected data cover 76% of all unique PubMed Medical Subject Headings descriptors. No systematic biases were observed across different experience levels, research fields or time spent on annotations. More importantly, annotations of the same document pairs contributed by different scientists were highly concordant. We further show that the three representative baseline methods used to generate recommended articles for evaluation (Okapi Best Matching 25, Term Frequency-Inverse Document Frequency and PubMed Related Articles) had similar overall performances. Additionally, we found that these methods each tend to produce distinct collections of recommended articles, suggesting that a hybrid method may be required to completely capture all relevant articles. The established database server located at https://relishdb.ict.griffith.edu.au is freely available for the downloading of annotation data and the blind testing of new methods. We expect that this benchmark will be useful for stimulating the development of new powerful techniques for title and title/abstract-based search engines for relevant articles in biomedical research.Peer reviewe

Advancements in dementia research, diagnostics and care in Latin America : highlights from the 2023 Alzheimer's association international conference satellite symposium in Mexico City

While Latin America (LatAm) is facing an increasing burden of dementia due to the rapid aging of the population, it remains underrepresented in dementia research, diagnostics and care. In 2023, the Alzheimer’s Association hosted its eighth Satellite Symposium in Mexico, highlighting emerging dementia research, priorities, and challenges within LatAm. A wide range of topics were covered, including epidemiology, social determinants, dementia national plans, risk reduction, genetics, biomarkers, biobanks, and advancements in treatments. Large initiatives in the region including intra-country support showcased their efforts in fostering national and international collaborations; genetic studies unveiled the unique genetic admixture in LatAm; emerging clinical trials discussed ongoing culturally specific interventions; and the urgent need to harmonize practices and studies, improve diagnosis and care and implement affordable biomarkers in the region was highlighted

Embracing Monogenic Parkinson's Disease: The MJFF Global Genetic PD Cohort

© 2023 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.[Background] As gene-targeted therapies are increasingly being developed for Parkinson's disease (PD), identifying and characterizing carriers of specific genetic pathogenic variants is imperative. Only a small fraction of the estimated number of subjects with monogenic PD worldwide are currently represented in the literature and availability of clinical data and clinical trial-ready cohorts is limited.[Objective] The objectives are to (1) establish an international cohort of affected and unaffected individuals with PD-linked variants; (2) provide harmonized and quality-controlled clinical characterization data for each included individual; and (3) further promote collaboration of researchers in the field of monogenic PD.[Methods] We conducted a worldwide, systematic online survey to collect individual-level data on individuals with PD-linked variants in SNCA, LRRK2, VPS35, PRKN, PINK1, DJ-1, as well as selected pathogenic and risk variants in GBA and corresponding demographic, clinical, and genetic data. All registered cases underwent thorough quality checks, and pathogenicity scoring of the variants and genotype–phenotype relationships were analyzed.[Results] We collected 3888 variant carriers for our analyses, reported by 92 centers (42 countries) worldwide. Of the included individuals, 3185 had a diagnosis of PD (ie, 1306 LRRK2, 115 SNCA, 23 VPS35, 429 PRKN, 75 PINK1, 13 DJ-1, and 1224 GBA) and 703 were unaffected (ie, 328 LRRK2, 32 SNCA, 3 VPS35, 1 PRKN, 1 PINK1, and 338 GBA). In total, we identified 269 different pathogenic variants; 1322 individuals in our cohort (34%) were indicated as not previously published.[Conclusions] Within the MJFF Global Genetic PD Study Group, we (1) established the largest international cohort of affected and unaffected individuals carrying PD-linked variants; (2) provide harmonized and quality-controlled clinical and genetic data for each included individual; (3) promote collaboration in the field of genetic PD with a view toward clinical and genetic stratification of patients for gene-targeted clinical trials. © 2023 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.This project was funded by The Michael J. Fox Foundation (ID 15015.02)Peer reviewe