179 research outputs found
Understanding the clinical spectrum of complicated Plasmodium vivax malaria: a systematic review on the contributions of the Brazilian literature
- Author
- A Guindo
- A Kumar
- AA Fernandes
- ACL Moura
- AJ Rodriguez-Morales
- AM Melo
- AM Siqueira
- AM Tavares
- AM Ventura
- AMRS Ventura
- Ana MRS Ventura
- André M Siqueira
- AntĂŽnio R Silva
- AP Costa
- AV Lomar
- B Genton
- BB Andrade
- BB Andrade
- BB Andrade
- BB Lakhkar
- BC Albuquerque
- BE Gama
- Belisa ML MagalhĂŁes
- BO Carvalho
- C Botelho
- C Chagas
- C Fernandez-Becerra
- C Fernandez-Becerra
- C Illamperuma
- C Mendes
- C Menendez
- CA Guerra
- CCBS Raposo
- CE Cavasini
- CE Cavasini
- CF Araujo
- CHAB Menezes
- CHAB Menezes
- CHL Park
- CJC Bastos
- CT Hamel
- D Batista
- DA Lampah
- DK Kochar
- DK Kochar
- DK Kochar
- DK Kochar
- DK Kochar
- DS Walsh
- E Tjitra
- EC Chagas
- EFA Moura
- EFC Lança
- EMN Kalmar
- F Nosten
- FE Martinez-Espinosa
- Flor E Martinez-Espinosa
- FM Campos
- FP Alves
- Franklin S Santana Filho
- FS Santana Filho
- FT Costa
- FY Khan
- GA Cardoso
- GC Melo
- GMC Viana
- GS Mello
- HH Marques
- HO Marques
- I Mueller
- IBA Silva
- IBA Silva
- IBA Silva
- J Oliveira-Ferreira
- J Penna
- J Wildig
- JC Fonseca
- JD Urbaez-Brito
- JF Zumpano
- JH Lee
- JJO Neves
- JP Quintero
- JR Poespoprodjo
- JR Poespoprodjo
- JY Song
- K Maitland
- K Mendis
- K Silamut
- K Takaki
- LK Tan
- LMP Borzacov
- LRP Campos
- M Echeverri
- MA Alexandre
- MA Cardoso
- Marcus VG Lacerda
- Maria GC Alecrim
- Maria PG MourĂŁo
- Mauro S Tada
- MB Victoria
- MC Silva
- MCN Pinheiro
- MD Braga
- MDO Ohnishi
- MDO Ohnishi
- ME Curlin
- ME Ferreira
- MG Alecrim
- MG Saraiva
- MGC Alecrim
- MGC Alecrim
- MJF Gonçalves
- MP Mourao
- MR Galinski
- MS Oliveira
- MS Santana
- MS Santana
- MSS Pereira
- MT Cavasini
- MU Ferreira
- MV Lacerda
- MV Lacerda
- MV Lacerda
- MV Lacerda
- MVG Lacerda
- MVG Lacerda
- MVG Lacerda
- MVG Lacerda
- MĂĄrcia AA Alexandre
- ND Karunaweera
- NM Anstey
- NM Anstey
- NM Douglas
- NMA Evangelista
- NSV Guerreiro
- O Caicedo
- O Erel
- P Grynberg
- P Michon
- P Orjuela-Sanchez
- P Reiter
- PA Zimmerman
- PatrĂcia Brasil
- PC Pereira
- PD Santos-Ciminera
- PD Santos-Ciminera
- PHO Cabral
- PJ Poels
- PS AragĂŁo
- Q Bassat
- Q Bassat
- R Jarude
- R Siqueira-Batista
- R Srinivas
- R Stoppacher
- R Vermehren
- Rita SU Silva
- RL Gurgel
- RN Charrel
- RN Price
- RN Price
- RSM Oliveira
- S Lewallen
- S Picot
- S Pukrittayakamee
- S Sahoo
- S Vitor-Silva
- SB Halstead
- SB Pessoa
- SBR Silva
- SC Austin
- SC Fragoso
- SCP Fragoso
- SJ Rogerson
- SK Kochar
- SL Silva
- SN Wickramasinghe
- SR Albuquerque
- T Leslie
- TH Katsuragawa
- TH Katsuragawa
- TN Williams
- V Bussaratid
- V Severo
- Vanja SCD Couto
- VS Santana
- W Piyaphanee
- WHO
- WHO
- WM Ramos Jr
- YF Sardinha
- Publication venue
- BioMed Central
- Publication date
- 01/01/2012
- Field of study
The resurgence of the malaria eradication agenda and the increasing number of severe manifestation reports has contributed to a renewed interested in the Plasmodium vivax infection. It is the most geographically widespread parasite causing human malaria, with around 2.85 billion people living under risk of infection. The Brazilian Amazon region reports more than 50% of the malaria cases in Latin America and since 1990 there is a marked predominance of this species, responsible for 85% of cases in 2009. However, only a few complicated cases of P. vivax have been reported from this region. A systematic review of the Brazilian indexed and non-indexed literature on complicated cases of vivax malaria was performed including published articles, masters' dissertations, doctoral theses and national congresses' abstracts. The following information was retrieved: patient characteristics (demographic, presence of co-morbidities and, whenever possible, associated genetic disorders); description of each major clinical manifestation. As a result, 27 articles, 28 abstracts from scientific events' annals and 13 theses/dissertations were found, only after 1987. Most of the reported information was described in small case series and case reports of patients from all the Amazonian states, and also in travellers from Brazilian non-endemic areas. The more relevant clinical complications were anaemia, thrombocytopaenia, jaundice and acute respiratory distress syndrome, present in all age groups, in addition to other more rare clinical pictures. Complications in pregnant women were also reported. Acute and chronic co-morbidities were frequent, however death was occasional. Clinical atypical cases of malaria are more frequent than published in the indexed literature, probably due to a publication bias. In the Brazilian Amazon (considered to be a low to moderate intensity area of transmission), clinical data are in accordance with the recent findings of severity described in diverse P. vivax endemic areas (especially anaemia in Southeast Asia), however in this region both children and adults are affected. Finally, gaps of knowledge and areas for future research are opportunely pointed out
Moving beyond neurons: the role of cell type-specific gene regulation in Parkinson's disease heritability
- Author
- Adarmes-Gomez AD
- Aguilar M
- Alvarez I
- Alvarez V
- Anderson T
- Bandres-Ciga S
- Bentley S
- Bergareche Yarza JA
- Bernal-Bernal I
- Billingsley K
- Blauwendraat C
- Blazquez M
- Bonilla-Toribio M
- Botia J
- Bras J
- Brice A
- Brockmann K
- Buiza-Rueda D
- Camara A
- Carcel M
- Carlos Martinez-Castrillo J
- Carrillo F
- Carrion-Claro M
- Cerdan D
- Chelban V
- Clarimon J
- Compta Y
- Cookson MR
- Corvol J-C
- Dalrymple-Alford J
- Danjou F
- de Munain Arregui AL
- Diez-Fairen M
- Dis SGP
- Dols-Icardo O
- Duarte J
- Duran R
- Escamilla-Sevilla F
- Escott-Price V
- Ezquerra M
- Faghri F
- Fernandez M
- Fernandez-Santiago R
- Finkbeiner S
- Foltynie T
- Fowdar J
- Gan-Or Z
- Garcia C
- Garcia-Ruiz P
- Gasser T
- Genomics IPD
- Gibbs JR
- Giri A
- Gomez Heredia MJ
- Gomez-Garre P
- Gonzalez-Aramburu I
- Gorostidi Pagola A
- Gratten J
- Guerreiro R
- Halliday G
- Hardy J
- Henders AK
- Hernandez DG
- Heutink P
- Hickie I
- Hoenicka J
- Holmans P
- Houlden H
- Infante J
- Javier Barrero F
- Jesus S
- Jimenez-Escrig A
- Jose Marti M
- Kassam I
- Kennedy M
- Kia DA
- Kinghorn KJ
- Koks S
- Krohan L
- Kulisevsky J
- Kwok J
- Labrador-Espinosa MA
- Leonard H
- Lesage S
- Lewis P
- Lewis S
- Lovering R
- Lubbe S
- Luis Lopez-Sendon J
- Lungu C
- Macias D
- Majamaa K
- Marin J
- Marinus J
- Martinez Torres I
- Martinez M
- Mellick G
- Mencacci NE
- Mendez-del-Barrio C
- Menendez Gonzalez M
- Middlehurst B
- Minguez A
- Mir P
- Mok KY
- Mondragon Rezola E
- Montgomery G
- Morris HR
- Munoz E
- Nalls MA
- Nicolas A
- Noyce AJ
- Ojo OO
- Okubadejo NU
- Pablo Tartari J
- Pagonabarraga J
- Pastor P
- Pearson J
- Perez Errazquin F
- Perinan-Tocino T
- Pihlstrom L
- Pitcher T
- Plun-Favreau H
- Quinn J
- R'Bibo L
- Reed X
- Reynolds RH
- Rizig M
- Rizzu P
- Robak L
- Rouleau GA
- Ruiz-Martinez J
- Ruz C
- Ryten M
- Sanchez Rodriguez A
- Scholz SW
- Schulte C
- Sharma M
- Shulman JM
- Sidorenko J
- Sierra M
- Siitonen A
- Silburn PA
- Simon-Sanchez J
- Singleton AB
- Suarez-Sanmartin E
- Taba P
- Tabernero C
- Taliun SAG
- Tan M
- Tejera-Parrado C
- Teresa Boungiorno M
- Tolosa E
- Trabzuni D
- Tucci A
- Valldeoriola F
- Vallerga CL
- van Hilten JJ
- Vargas-Gonzalez L
- Vela L
- Visscher PM
- Vives F
- Wallace L
- Williams N
- Wood NW
- Wray NR
- Xue A
- Yang J
- Zhang F
- Zimprich A
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2019
- Field of study
Parkinsonâs disease (PD), with its characteristic loss of nigrostriatal dopaminergic neurons and deposition of α-synuclein in neurons, is often considered a neuronal disorder. However, in recent years substantial evidence has emerged to implicate glial cell types, such as astrocytes and microglia. In this study, we used stratified LD score regression and expression-weighted cell-type enrichment together with several brain-related and cell-type-specific genomic annotations to connect human genomic PD findings to specific brain cell types. We found that PD heritability attributable to common variation does not enrich in global and regional brain annotations or brain-related cell-type-specific annotations. Likewise, we found no enrichment of PD susceptibility genes in brain-related cell types. In contrast, we demonstrated a significant enrichment of PD heritability in a curated lysosomal gene set highly expressed in astrocytic, microglial, and oligodendrocyte subtypes, and in LoF-intolerant genes, which were found highly expressed in almost all tested cellular subtypes. Our results suggest that PD risk loci do not lie in specific cell types or individual brain regions, but rather in global cellular processes detectable across several cell types
Demographic, clinical and antibody characteristics of patients with digital ulcers in systemic sclerosis: data from the DUO Registry
- Author
- Adoue D
- Agard C
- Ahmadi K
- Airo P
- Aizpuru EM
- Akanay-Diesel S
- Albertsson K
- Almeida I
- Alsheimer B
- Alves J
- Andersen M
- Anderson M
- Andresen J
- Angeles Aquirre M
- Antivalle M
- Aries P
- Aslanidis S
- Aslkaksen HK
- Assmann G
- Assous N
- Athanassiou P
- Athiveer P.
- Baguley E
- Bajoochi G
- Bakkeheim V
- Bakland G
- Balquiere S
- Barbado J
- Barca BA
- Barnd A
- Barth S
- Battaglia E
- Baudaoin P
- Baumann C
- Becerra ND
- Becker M
- Becvar R
- Bekou V
- Belin E
- Bellido D
- Bellisai F
- Bellissimo S
- Belloli L
- Belloni B
- Bendvold A
- Beneton N
- Berezne A
- Berthier S
- Bessis D
- Beyer C
- Bezanahary H
- Bijl M
- Bitter H
- Blaise S
- Blanco JJ
- Blanco JS
- Blank N
- Bloching HH
- Blum L
- Blume J
- Boesenberg I
- Bohmova J
- Bootsma H
- Boro D
- Bortoluzzi A
- Boulon C
- Boussely N
- Bracin T
- Brand H
- Bravetti V
- Brodmann M
- Broll H
- Brouwer L
- Brown S
- Bruckner L
- Bruyn G
- Bucci R
- Caamano M
- Cabane J
- Callejas JL
- Calvo J
- Camara I
- Camps MT
- Cantatore F
- Carpentier P
- Cartry O
- Castellvi I
- Castellvi I
- Cazalets-lacoste C
- Chakravarty K
- Charlanne H
- Chatelus E
- Chiffot H
- Choong LM
- Chromik S
- Cipriani P
- Coelho P
- Cohen JD
- Colaci M
- Cole S
- Coleman JV
- collet E
- Colonna L
- Constans J
- Coppere B
- Cordeiro A
- Corteguera M
- Costa J
- Couraud A
- Couret B
- Cozzi F
- Crespo M
- Cruz A
- Cruz J
- Cuomo G
- D'Cruz D
- Dadban A
- De Angeli R
- de Bois M
- De la Puente C
- de la Torre RG
- de Long AJ
- de Ramon E
- de Vicuna RG
- De Vita S
- Deboves O
- Decaux O
- Deininger F
- del Carmen Ortega de la O M
- del Carmen Torres Martin M
- del la Pena Lefebvre PG
- del Mar Ripoll Macias M
- Del Papa N
- del Rio AH
- Delgado EG
- den Hengst C
- Denton C
- Denton CP
- Deppermann N
- Desmurs-Clavel H
- Deuschle K
- Diaz JJ
- Dietl S
- Dimitroulas T
- Diot E
- Distler J
- Distler O
- Dobson J
- Doeffel-hantz V
- Dohse A
- Dolhain R
- Dolnicar AS
- Doutre MS
- Doveri M
- Droitcourt C
- Dumonteil S
- DUO Registry investigators. Collaborators: Stetter M
- Durant C
- Duval-modeste AB
- Dyballa J
- Ebel J
- Eiden E
- Eilbacher P
- Elezoglou A
- Enderlein M
- Erfurt-berge C
- Espinosa G
- Espinposa G
- Ewals J
- Faggioli P
- Faizal A
- Farcas C
- Farge D
- Fauchais AL
- Faustini F
- Federow I
- Feldmann R
- Fell I
- Fernandez AS
- Fernandez C
- Fernandez NC
- Fernandez S
- Ferraccioli G
- Ferrandiz D
- Ferri C
- Fiene M
- Fierlbeck G
- Filloy JA
- Flaig W
- Fojtik Z
- Foti R
- Frambach Y
- Frances C
- Fretter P
- Freundlieb C
- Frey P
- Funkert A
- Fusaro E
- Fuzibet JG
- Gabrielli A
- Gaches F
- Galanopoulo V
- Galanopoulos N
- Galeazzi M
- Galluccio F
- Garcia A
- Garcia PV
- Garyfallos A
- Gatti S
- Gaubitz M
- Gause A
- Gawlik A
- Gerards AH
- Gerber A
- Gerdes V
- Gernot Scheibl E
- Geurts M
- Gil JG
- Gines Martinez F
- Girard-Madoux MH
- Gjessdal CG
- Glaeser R
- Goekoop R
- Gonzales MF
- Gordon P
- Goudran G
- Grandauent B
- Granel B
- Granel-brocard F
- Grassi W
- Greco M
- Grier A
- Groenendael JH
- Groenendael J
- Guenzel J
- Guertler I
- Guillevin L
- Guillevin L
- Hachulla E
- Hafner F
- Hahn K
- Hak AE
- Hall F
- Hallecker A
- Hallermann C
- Hamberger N
- Hamilton A
- Hampson R
- Han KH
- Hapke S
- Harmuth W
- Harris H
- Hartmann F
- Hassel R
- Hatron PY
- Haust M
- Hazenbiller A
- Hein R
- Hellmich B
- Hellstrom H
- Henkemeier U
- Hermanns G
- Hermansson E
- Hernan MG
- Herr U
- Herrgott I
- Herrick A
- Heurkens AH
- Hildebrandt B
- Hillebrecht C
- Himsel A
- Hirschl M
- Hjertaker SL
- Hoff NP
- Hoffmann-Vold AM
- Holzer G
- Hot A
- Houben H
- Huegel R
- Huertas MP
- Huettig B
- Huizinga TW
- Hulsmans H
- Hundstorfer M
- Hurkens T
- Illmer X
- Imbert B
- Insua SA
- Iversen LV
- Jacobs PJ
- Jahangier de Veen ZN
- Jahnke K
- James J
- Jansen P
- Janssen M
- Jego P
- Jourdain N
- Kaarto A
- Kaasjager HA
- Kaczmarczyk A
- Kaeding U
- Kahl S
- Kalstad S
- Kamali S
- Kampe-Juzak E
- Kanter MD
- Karaenke P
- Karlsmark T
- Karlsson ML
- Katzemich A
- Kayser M
- Kellner C
- Kelsey C
- Kern S
- Keshtmand H
- Kettenbach A
- Keynote A
- Khau van Kien A
- Kirchberg S
- Kirschke J
- Klein E
- Kleiner HJ
- Klings D
- Kneitz C
- Knifjj-Dutmer E
- Knoebel K
- Knudsen JB
- Koch M
- Koldingsnes W
- Kolle H
- Kostrzwewa E
- Koutroumbas A
- Krause Rostock JO
- Kremer K
- Krieg T
- Kritikos I
- Krog B
- Krupp E
- Kuen-Spiegel M
- Kuiper-geertsma DG
- Kunze S
- Kurthen R
- Kyndt X
- Lackner K
- Lamb J
- Lambert M
- Landewe RM
- Lanting P
- Lapadula G
- Launay D
- Laurin CU
- Lauterwein B
- Lazareth I
- Le Quellec A
- Lebrun C
- Leguy-Seguin V
- Letremy A
- Liljequist E
- Lind I
- Lind K
- Linke M
- Loeffler C
- Lok C
- Lombardi S
- Lopez JC
- Lopez MR
- Losada L
- Loustaud-ratti V
- Luethke K
- Lukac J
- Lunardi C
- Lupaschko S
- Maceiras F
- Madaule S
- Madhok F
- Madland TM
- Maglione W
- Magy-Bertrand N
- Maillard H
- Makinen H
- Malavolta N
- Manea P
- Maneiro JR
- Manning J
- Manzanedo VS
- Margeta C
- Marhuenda AR
- Marina P
- Martin I
- Marucci A
- Marx J
- Mascaro JM
- Masolini P
- Mateo FJ
- Matucci-Cerinic M
- Maurer B
- May D
- Mayer L
- Mazzone A
- Mazzuca S
- Mchugh N
- Meier L
- Meier U
- Mendoza AZ
- Mengden T
- Mensing C
- Mensing H
- Mera A
- Merk B
- Mesaric P
- Messall J
- Messer G
- Mettler S
- Metz S
- Metzler C
- Michon-Pasturel U
- Midtvedt O
- Miguelez R
- Minmair G
- Misery L
- Mitchell A
- Mittag M
- Mohammad A
- Moinzadeh P
- Moiton MP
- Molders N
- Moline T
- Monshausen M
- Monshi B
- Montecucco CM
- Montes IC
- Montes J
- Moolenburgh JD
- Moore T
- Moosig F
- Moots R
- Morell S
- Moritz D
- Morrison C
- Mosquera JA
- Mota R
- Moulis G
- Mouthon L
- Mueglich C
- Muhlack A
- Muller WH
- Munoz J
- Murphy K
- Murray M
- Mussi A
- Naderi Y
- Neek G
- Nemec P
- Neul S
- Ngcozana T
- Nichelmann V
- Nicolas GM
- Niedermeier A
- Niefanger K
- Nielen C
- Nigro A
- Ninet J
- Noordzij M
- Nordin A
- Nordvag BY
- O'Rourke M
- Ochiel R
- Ochs W
- Oelsner M
- Ogunbambi G O
- Oliveira S
- Olivieri I
- Olsen AB
- Oltmann-Schroeder J
- Ortego N
- Ostenson A
- Paassen P
- Pallotta S
- Pampin EP
- Parker L
- Pedersen T
- Pellerito R
- Perlat A
- Peters AJ
- Peters J
- Pfeiffer C
- Pflugfelder J
- Pfoehler C
- Pirkhammer D
- Plaumann K
- Podda M
- Podobinska M
- Ponte C
- Prey S
- Priollet P
- Prochazkova L
- Pros A
- Puppo F
- Quemeneur T
- Queyrel V
- Rabaneda EV
- Rabe B
- Raffier B
- Ramos PC
- Rapp P
- Rasche C
- Rauen T
- Reemtsen R
- Reguiai Z
- Reinhart V
- Reischel N
- Remans J
- Resende C
- Riccieri V
- Richez C
- Richter L
- Riemekasten G
- Rintelen B
- Riviere S
- Rizk M
- Robakidze-Torbahn M
- Rodriguez MA
- Rodriguez TR
- Roman Ivorra J
- Ronday K
- Rosato E
- Rosenberg D
- Rubio M
- Ruchenburg J
- Rueda A
- Rullier P
- Rumbaur C
- Rumpel H
- Rushentsova U
- Rydvald Y
- Sadeghlar F
- Saez L
- Sailler L
- Salerno R
- Salsano F
- Sanchez J
- Sanchez MD
- Sanchez PS
- Sancho Alegre JJ
- Sandoval AA
- Santo MP
- Santos C
- Saracco M
- Sardy M
- Sassolas B
- Sautner J
- Schaefer C
- Schanz S
- Schildt K
- Schleenbecker H
- Schmeiser T
- Schmidt K
- Schmidt P
- Schmidt-Bosshard R
- Schneider K
- Scholz J
- Schuart T
- Schuch F
- Schuerwegh A
- Schuetz N
- Schult S
- Schultz L
- Schulze K
- Schuster J
- Schwarting A
- Schweda K
- Schwierin B
- Schwuerzer-Voit M
- Scorza R
- Seidel M
- Seip M
- Semmelweis K
- Semmler M
- Serafino L
- Severino A
- Seys P
- Sheikh N
- Sibillia J
- Siebel C
- Siewertsz van Reesema D
- Silkey M
- Silva I
- Simeon CP
- Skingle S
- Skomsvoll J
- Skowron F
- Skyes H
- SMIT A
- Smrzova A
- Soderlin M
- Sondergaard KH
- Sonnaville PB
- Sordet C
- Soukup T
- Spars A
- Sperling S
- Starz H
- Stein T
- Steinbrink K
- Sticherling M
- Stisi S
- Stoeckl F
- Stolk JN
- Storck-Mueller K
- Stran EK
- Stroes ES
- Suchy D
- Taieb A
- Takacs M
- Tasende JA
- Terlizzi N
- Thomsen RS
- Thonhofer R
- Thorsson C
- Tiev K
- Tiggers C
- Toeller S
- Toledano C
- Tomi N
- Ton E
- Tony HP
- Trautinger F
- Trenado MS
- Triolo G
- Trotta F
- Trummer M
- Tsifetaki N
- Ubels F
- Ughi N
- Uhlig S
- Ullrich-Guenther C
- Unholzer A
- Uson J
- Vacca A
- Valentijn R
- van Hagen M
- van Daele P
- van den Hoogen F
- van der Lubbe P
- van der Veen MJ
- van Gameren I
- Van Guldener C
- Van Krugten M
- Van Neer F
- van Paassen H
- van Woerkom JM
- van Zeben D
- Varcasia G
- Vasilopoulos D
- Vazquez JL
- Vengemyr K
- Vercoutere W
- Verner D
- Victoria Egurbide M
- Vidal E
- Villaverde V
- Vincent R
- Vingren T
- Visser H
- Vlachoyannopoulos P
- von Bildering PB
- von Elling A
- von Oelhafen J
- Vonk M
- Vos P
- Voskuyl A
- Voss B
- Vosswinkel J
- Wagner N
- Wahl D
- Wahn H
- Waldheim E
- Weiss E
- Welzel J
- Wernitzsch H
- Westedt ML
- Westra R
- White-Alao B
- Wilhelm HU
- Willems H
- Willfort-Ehringer A
- Wipff J
- Wlarvens M
- Woijtasik G
- Wollersdorfer E
- Worm M
- Wragg E
- Wuerzburg I
- Xu Y
- Zabel M
- Zemanova I
- Zeni S
- Zenone T
- Zeuner R
- Ziai M
- Zijlstra TR
- Zimba S
- Zuily S
- Zultak M
- Zuper R
- Zwenger S
- Publication venue
- BMJ Group
- Publication date
- 01/01/2012
- Field of study
OBJECTIVES: The Digital Ulcers Outcome (DUO) Registry was designed to describe the clinical and antibody characteristics, disease course and outcomes of patients with digital ulcers associated with systemic sclerosis (SSc).
METHODS: The DUO Registry is a European, prospective, multicentre, observational, registry of SSc patients with ongoing digital ulcer disease, irrespective of treatment regimen. Data collected included demographics, SSc duration, SSc subset, internal organ manifestations, autoantibodies, previous and ongoing interventions and complications related to digital ulcers.
RESULTS: Up to 19 November 2010 a total of 2439 patients had enrolled into the registry. Most were classified as either limited cutaneous SSc (lcSSc; 52.2%) or diffuse cutaneous SSc (dcSSc; 36.9%). Digital ulcers developed earlier in patients with dcSSc compared with lcSSc. Almost all patients (95.7%) tested positive for antinuclear antibodies, 45.2% for anti-scleroderma-70 and 43.6% for anticentromere antibodies (ACA). The first digital ulcer in the anti-scleroderma-70-positive patient cohort occurred approximately 5 years earlier than the ACA-positive patient group.
CONCLUSIONS: This study provides data from a large cohort of SSc patients with a history of digital ulcers. The early occurrence and high frequency of digital ulcer complications are especially seen in patients with dcSSc and/or anti-scleroderma-70 antibodies
A922 Sequential measurement of 1 hour creatinine clearance (1-CRCL) in critically ill patients at risk of acute kidney injury (AKI)
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- Jung K
- Jung KW
- Junior JM
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- Kalenka A
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- Kamali E
- Kaminsky GE
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- Knight LD
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- Ko SB
- Kobayashi A
- Koco E
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- Kodate A
- Kodate A
- Kokkini S
- Kolnikova I
- Komuro T
- Kondili E
- Kongpolprom N
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- Kou PS
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- Krenn CG
- Krishna B
- Kristof J
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- Kumari BK
- Kumbamu A
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- Kurth T
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- Kwon HM
- Kwon WY
- Kwon WY
- Kwon WY
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- Kyle UG
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- Labra C
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- Lafuente E
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- Lagos R
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- MartĂnez F
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- Merino-Vega D
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- Midwinter MJ
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- Okayama Research Investigation Organizing Network (ORION)investigators
- Olaechea P
- Olavarria E
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- Panciera G
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- Pastor EE
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- Pham T
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- Pickkers P
- Pickkers P
- Picoita F
- PICS- HCPA: Programa Intrahospitalar de Combate Ă Sepse do Hospital de ClĂnicas de Porto Alegre
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- Plug Working Group
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- Pozzi M
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- Preau S
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- Price RD
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- Prowle JR
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- Pugliese F
- Pujol LM
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- Putzu A
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- Rapid Diagnosis of Infections in the Critically Ill Team
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- ReVA Research Network and the PROVE Network Investigators
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- RodrĂguez FG
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- Romero I
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- Rood PJ
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- Rosario LE
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- Rottoli MR
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- Rubio RJ
- Rudiger A
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- Ruiz BL
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- Runge I
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- SabeÄŒĆikovs O
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- Samuels T
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- Sanchez JA
- Sanchez-Orézzoli MG
- Sandiumenge A
- Sandiumenge A
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- Sani D
- Santacruz C
- Santana JD
- Santana JD
- Santana MC
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- Santana PS
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- Santiago AI
- Santiago AI
- Santos F
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- Sanz NM
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- Sawamura A
- Sawamura A
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- Scales DC
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- Shimony JS
- Shin WJ
- Shin WJ
- Shinotsuka CR
- Shlyk I
- Shu CW
- Shuinotsuka C
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- Shum HP
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- Siddiqui SS
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- Spadaro S
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- Spatenkova V
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- Spronk PE
- Spronk PE
- Sprung CL
- St Georgeâs University of London
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- Stretti F
- Struijs A
- Stubbs C
- Stubbs C
- Student Research Committee - Shiraz University of Medical Sciences
- StĂŒmpfle R
- StĂŒmpfle R
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- Su PL
- Suchomel P
- Suh GJ
- Suh GJ
- Suh GJ
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- Sun XM
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- SĂĄnchez MJ
- SĂĄnchez MJ
- SĂĄnchez MJ
- SĂĄnchez MJ
- SĂĄnchez MJ
- SĂĄnchez PC
- SĂĄnchez PC
- SĂĄnchez-Elvira LA
- Tabatabaei HR
- Tabei SH
- Taccone F
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- Timsit JF
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- Tjepkema-Cloostermans MC
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- Tofiño AL
- Toh CH
- Tokyo Womens Medical University
- Tomas E
- Tomas E
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- Tonetti T
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- Welters I
- Wetz A
- Weyer CM
- White C
- Wiesner O
- Wijayatilake DS
- Wildenberg L
- Wilks M
- Wilson ME
- WIND study group
- WIND study group
- WIND study group
- Winder-Rhodes S
- Witter T
- Wolf M
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- Yang JH
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- Yasuda H
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- Yebenes JC
- Yeh YC
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- Yergaliyeva A
- Yılmaz G
- Yilmazer F
- Yodice P
- Yokoyama M
- Yonis H
- Yonis H
- Yonis H
- Yoon SZ
- Yoruk F
- Yoshida K
- Yoshida T
- Yoshida T
- Yoshida T
- Yoshida T
- Yoshihiro S
- Yoshitake E
- You KM
- Youn AM
- Young A
- Yu KM
- Yumoto T
- Yuzawa J
- Yuzawa J
- Zabaletta WJ
- Zabini D
- Zahorec M
- Zaien I
- Zakynthinos S
- Zanello M
- Zani D
- Zarantonello F
- Zayas B
- Zepeda EM
- Zeroual N
- Zerva L
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- Zhovnir V
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- Zwaag J
- ZĂœkovĂĄ I
- Ălvarez JT
- Ălvarez-Lerma F
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2016
- Field of study
Meeting abstrac
Search for Dark Matter and Supersymmetry with a Compressed Mass Spectrum in the Vector Boson Fusion Topology in Proton-Proton Collisions at root s=8 TeV
- Author
- Aarrestad TK
- Abbaneo D
- Abbiendi G
- Abbrescia M
- Abdullin S
- Abdulsalam A
- Abu Zeid S
- Ackert A
- Acosta D
- Acosta JG
- Adair A
- Adam W
- Adams JR
- Adams MR
- Adams T
- Adiguzel A
- Adzic P
- Agapitos A
- Aggleton R
- Agram J-L
- Ahmad A
- Ahmad M
- Ahmad M
- Ahmed I
- Ahuja S
- Akchurin N
- Akgun B
- Al-bataineh A
- Albergo S
- Albrow M
- Alcaraz Maestre J
- Aldaya Martin M
- Alderweireldt S
- AldĂĄ JĂșnior WL
- Aleksandrov A
- Alexander J
- Alimena J
- Almond J
- Alunni Solestizi L
- Alverson G
- Alves FL
- Alves GA
- Alyari M
- Amapane N
- Amsler C
- Anagnostou G
- Anderson D
- Anderson I
- Andrea J
- Andreev V
- Andreev Yu
- Andrews MB
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- Anelli C
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- Antropov I
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- Avetisyan A
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- Awad A
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- Azhgirey I
- Aziz T
- Azzi P
- Azzolini V
- Azzurri P
- Baarmand MM
- Baber M
- Bacchetta N
- Bachmair F
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- Baden A
- Baffioni S
- Bagliesi G
- Bahinipati S
- Baillon P
- Bainbridge R
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- Barney D
- Baron O
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- Bartosik N
- BartĂłk M
- Baskakov A
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- Baty A
- Bauerdick LAT
- Baumgartel D
- Baus C
- Bayshev I
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- BeirĂŁo Da Cruz E Silva C
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- Da Silveira GG
- Dabrowski A
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- Publication venue
- Publication date
- 01/01/2016
- Field of study
Peer reviewe
Lawson criterion for ignition exceeded in an inertial fusion experiment
- Author
- Abu-Shawareb H
- Acree R
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- Publication venue
- 'American Physical Society (APS)'
- Publication date
- 06/07/2022
- Field of study
For more than half a century, researchers around the world have been engaged in attempts to achieve fusion ignition as a proof of principle of various fusion concepts. Following the Lawson criterion, an ignited plasma is one where the fusion heating power is high enough to overcome all the physical processes that cool the fusion plasma, creating a positive thermodynamic feedback loop with rapidly increasing temperature. In inertially confined fusion, ignition is a state where the fusion plasma can begin "burn propagation" into surrounding cold fuel, enabling the possibility of high energy gain. While "scientific breakeven" (i.e., unity target gain) has not yet been achieved (here target gain is 0.72, 1.37Â MJ of fusion for 1.92Â MJ of laser energy), this Letter reports the first controlled fusion experiment, using laser indirect drive, on the National Ignition Facility to produce capsule gain (here 5.8) and reach ignition by nine different formulations of the Lawson criterion
Antiinflammatory Therapy with Canakinumab for Atherosclerotic Disease
- Author
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- Krapivsky A
- Kreckova M
- Kreutter F
- Krupciakova B
- Krupicka J
- Kuenzler J
- Kulibaba E
- Kulkarni L
- Kullal P
- Kultursay H
- Kumar Ks
- Kumbla M
- Kuntzsch A
- Kuo Jy
- Kuramochi T
- Kuruma T
- Kusnick B
- Kuzin A
- Kyo E
- L Levinson
- L Lim
- L Link
- L Liu
- Laane E
- Labovitz R
- Lachance P
- Lai Wt
- Lail J
- Lainscak M
- Lake J
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- Lameira A
- Lamontagne C
- Landers B
- Landolfi A
- Landzberg J
- Lang C
- Langdon J
- Laniec M
- Lappo M
- Lardinois R
- Laszlo Z
- Latheef K
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- Ledger G
- Lee Hn
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- Lee Jh
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- Leggewie S
- Lehman Kf
- Lehman R
- Lehmann D
- Leimbach W
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- Lembo G
- Lenderink T
- Lennard M
- Lenner E
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- Lepor N
- Lepp H
- Lester F
- Levin P
- Levine D
- Lewis D
- Li W
- Li X
- Li Y
- Li Y
- Li Y
- Li Yh
- Li Z
- Libby P
- Liberato Nl
- Libov I
- Lierse T
- Ligueros M
- Lillo J
- Lima F
- Limaye Ap
- Lin T
- Lindholm Cj
- Lindner C
- Liniado G
- Lino E
- Lipchenko A
- Liu B
- Liu B
- Liu Hm
- Liu P
- Liu S
- Liu Y
- Liviu C
- Lock E
- Lohkare M
- Lok Dja
- Long C
- Longaker R
- Lopes R
- Lopez P
- Lorch G
- Lorenc Z
- Lorenzatti A
- Lousberg A
- Lozhkina N
- Lu Z
- Luciardi H
- Lucksinger G
- Luecke-Uzar M
- Luedemann J
- Lukac J
- Lundqvist M
- Lupkovics G
- Luquez H
- Luz Serrano H
- Lv Y
- Lynd S
- Lysek R
- Lönnberg I
- M Malek
- M Mallagray
- M Mandati
- M Mandviwala
- M Marsters
- M Mays
- M Mcdonald
- M Medvegy
- M Meinrich
- M Mikus
- M Milanova
- M Moustafa
- Ma C
- Ma G
- Maboyi S
- Macdonald J
- Macfadyen Jg
- Machova V
- Madder R
- Maehara G
- Maffei L
- Magness K
- Maheshwari A
- Maheux K
- Maia L
- Majercak I
- Majul C
- Makedonska Jj
- Makhe B
- Makotoko E
- Malchikova S
- Maletz L
- Malhotra S
- Malhotra V
- Malik J
- Mancikova I
- Mandic L
- Manenti E
- Manfreda S
- Manga P
- Mani Ck
- Mani H
- Manne S
- Manning B
- Mannucci E
- Manolis A
- Manolis Aj
- Manov E
- Mantas I
- Manuel J
- Manukov D
- Manukov I
- Manyari D
- Manzur F
- Marcela Wenetz Lm
- Marchelletta N
- Marchi Al
- Marcinkeviciene J
- Marcun R
- Marengo Garcia De Carvalho L
- Marinaro S
- Marino P
- Mariottoni B
- Maron B
- Marschke T
- Marshall L
- Martin E
- Martin L
- Martinez E
- Martinez J
- Maruzzo S
- Marziali A
- Masarikova L
- Massaccesi R
- Mathew A
- Matyasek I
- Mauersberger K
- Maus O
- Mavromatis K
- Maximov D
- Mayer T
- Maynard R
- Mays B
- Mazutavicius R
- Mbulaiteye A
- Mcalister R
- Mccoy C
- Mccrary D Jr
- Mccullough-O'Brien H
- Mcgill J
- Mcgrew F
- Mcintosh C
- Mckenzie A
- Mckenzie C
- Mckibbin A
- Mclaurin B
- Mclellan Ba
- Mcmahon G
- Mcneil D
- Mcneill R
- Mcpherson C
- Medina F
- Megalou A
- Mehrle A
- Mehta A
- Mehta S
- Meijlis P
- Meissner A
- Mejia I
- Melbie K
- Mellberg L
- Melliza T
- Mendoza N
- Mendoza Y
- Mercuro G
- Merkely B
- Messina T
- Mestdagh I
- Meyer R
- Michalaros Y
- Michalska A
- Michaud N
- Michel K
- Mickel C
- Micko K
- Mihaly N
- Mikdadi G
- Mikusova T
- Milicic D
- Militaru C
- Miliuniene R
- Milkas A
- Miller A
- Miller C
- Miller G
- Miller R
- Miller W
- Minescu B
- Minocha G
- Mitchell J
- Mittal A
- Miyamoto T
- Moats Djr
- Modi R
- Mody F
- Moehring B
- Moen S
- Moffat J
- Mohan K
- Molina Di
- Molk B
- Molter D
- Monroe T
- Montana O
- Montenegro E
- Montenegro P
- Montero H
- Montgomery R
- Monti L
- Moodh J
- Mooe T
- Mookherjee D
- Moon K
- Moraes J Jr
- Moran J
- Moreira L
- Morell Y
- Moriarty P
- Morii I
- Morinaga Y
- Morisawa T
- Morozov E
- Morrison J
- Morton D
- Mos L
- Moshayedi P
- Mosley J
- Motiejuniene R
- Muehlhaus J
- Mueller S
- Muenter Kc
- Muenzel T
- Mulder R
- Munoz N
- Munoz R
- Munshi K
- Muntaner J
- Mureddu V
- Murphy G
- Murray A
- Mustafa J
- Musumeci Mb
- Muñoz W
- Myslyaeva L
- Nadar V
- Nagai Y
- Nagele-Luse I
- Nagy Ac
- Naidu R
- Naka T
- Nakamura S
- Nakamura Y
- Nakayoshi K
- Nalley J
- Nanas J
- Nandy P
- Naumann R
- Navarrete S
- Navy S
- Nebel J
- Neil L
- Nema D
- Neumann J
- Neutel Jm
- Niblack P
- Nicely V
- Nicolai M
- Nicolau J
- Nijmeh G
- Nikas A
- Nikoletta P
- Nikolic L
- Nikyar A
- Nilsen V
- Ning M
- Nishibe A
- Nixon S
- Nociar J
- Noori E
- Norin V
- Norkiene S
- Norkute-Macijauske U
- Norman L
- Noto G
- Nour K
- Novo S
- Nuding S
- Nugent A
- Nugteren Skz
- Ocman B
- Odegard A
- Ogawa H
- Ogawa M
- Okada Y
- Okawa M
- Okeefe D
- Olenchock B
- Olmedo M
- Olofsson M
- Olsen S
- Olsson Gh
- Olympios Cd
- Ondrasik J
- Onuchina E
- Oomman A
- Ord M
- Ortiz-Carrasquillo R
- Ossino N
- Otasevic P
- Otava M
- Otis R
- Otterstad Je
- Ouimet F
- Overhoff U
- Ozcan It
- OâNeil G
- P Pais
- P Peters
- P Piatti
- P Poliacik
- P Povolny
- P Purnell
- Pacora Ff
- Paez H
- Paganini M
- Page A
- Pagett K
- Pagnan M
- Pai R
- Pai V
- Palaniswami N
- Palatkina T
- Palchick B
- Pales J
- Paliwal Y
- Palka J Jr
- Palubova L
- Pande R
- Pandey S
- Paniagua A
- Pannell R
- Panov A
- Pansheriya A
- Panzarino C
- Papke B
- Parekh N
- Parente A
- Parepa I
- Parfait V
- Park B
- Park C
- Parmon E
- Partridge J
- Patel B
- Patel J
- Patel M
- Patel R
- Patel R
- Patel S
- Patino Jm
- Patole T
- Patsilinakos S
- Paulweber B
- Pavlickova L
- Paysor C
- Paz S
- Peck C
- Pella D
- Pena A
- Pencz I
- Peng L
- Penzes J
- Pereira S
- Perez Manghi F
- Perez A
- Perez M
- Perkins H
- Perkins L
- Perlstein T
- Perotti M
- Perperis A
- Perry B
- Pesce F
- Petelina T
- Peter Y
- Peterka M
- Petrauskiene B
- Petrescu L
- Petrillo C
- Petrov D
- Petrova I
- Petrusheva T
- Pettersen Ki
- Peukert Am
- Phillippi C
- Phillips A
- Phillips A
- Piacente R
- Pieretti Hb
- Pinheiro L
- Pintado M
- Pirenne B
- Pish R
- Piskorz D
- Pitt W
- Planinc I
- Ploechl A
- Plotz M
- Podoleanu C
- Pogson A
- Pokorna B
- Polato C
- Poling T
- Pomposini D
- Ponce T
- Poock J
- Pool T
- Poor F
- Pop Cf
- Popa V
- Popescu E
- Popovic Z
- Potts J
- Poudrier R
- Poulimenos L
- Pradhan A
- Pramatarova I
- Praveen M
- Prenner A
- Price D
- Price R
- Prior J
- Priori S
- Pritchard C
- Procter K
- Pupic L
- Purighalla R
- Pye M
- Qing L
- Quddusi K
- Quinones J
- Quinton D
- R Rauch
- R Recoaro
- R Reyes
- R Roettges
- R Rummel
- Racca V
- Radde I
- Radeljic V
- Radhakrishnan V
- Radin M
- Radoi M
- Radojcsics B
- Radvan M
- Raev D
- Ragghianti B
- Raghu C
- Rajan B A
- Rajasekhar D
- Rajput B
- Raju Ss
- Rama B
- Ramdas S
- Ramos G
- Ramos M
- Rancane G
- Randvee L
- Ranjith N
- Rao M
- Rao Mb
- Rao Nm
- Rassi S
- Rathnavel S
- Rathore A
- Rathore Srs
- Ratnik E
- Rau T
- Rawat S
- Raynes K
- Reber Am
- Reddy J
- Reddy Nc
- Redfearn H
- Rees Dh
- Reeves M
- Regner S
- Reichenbach D
- Reilly K
- Reimand M
- Reimer D
- Reinmets S
- Reis G
- Reis H
- Ren L
- Renaud K
- Renda G
- Repin A
- Resende I
- Resnick H
- Rewbury J
- Reznakova S
- Reznik I
- Rhudy Jm
- Richardson M
- Richert L
- Rickova Z
- Ridker Pm
- Riethof M
- Righini V
- Rinke A
- Risberg K
- Risenfors M
- Riser J
- Rivis L
- Robbins K
- Roberts-Thomson P
- Robinson S
- Rodero M
- Rodriguez Araya E
- Rodriguez A
- Rodriguez D
- Rodriguez J
- Rodriguez Lm
- Rodriguez Sm
- Roel A
- Romano A
- Romanski A
- Roos J
- Roper L
- Ross B
- Rossi Prf
- Rost N
- Roszkowska P
- Rotreklova M
- Roy A
- Roy C
- Roy M
- Rozeman P
- Ruder D
- Rudys A
- Ruffini L
- Rugo H
- Runev N
- Runquist L
- Rupka D
- Ruschel K
- Ryding A
- Rönndahl M
- RĂžnnevik P
- RĂžnnevik Td
- S Sarah
- S Sasaki
- S Sathe
- S Seki
- S Sharma
- S Shayani
- S Shetty
- S Shustov
- S Srivastava
- S Stadelmeier
- S Stoltz
- S Strand
- S Strugatsky
- S Such
- Sabo L
- Sack G
- Sahin M
- Sahin T
- Saini R
- Saint-Jacques H
- Saka B
- Sakamoto Y
- Sakurada M
- Salfity M
- Salinger M
- Salko T
- Sall N
- Saloustros I
- Salvador L
- Sam K
- Samal A
- Samer H
- Samkova D
- Sanchez Vallejo G
- Sanchez A
- Sanchez D
- Sang X
- Santiago J Jr
- Santosh Mj
- Sanuri M
- Saporito W
- Saraiva Jf
- Saravia Ma
- Sarbu I
- Sarcone M
- Sarjanovich R
- Sarma R
- Sarnighausen He
- Sarszegi Z
- Sattar N
- Saunders K
- Savard D
- Savignano C
- Saylor R
- Sazonova E
- Scaro G
- Scheffel M
- Scheibner T
- Schermaul Kh
- Schiavi Lb
- Schifferdecker B
- Schindler A
- Schindler A
- Schindler E
- Schlundt C
- Schmidt E
- Schmidt K
- Schnabel A
- Schneider P
- Schneider R
- Schnitzler R
- Schoen N
- Schorn K
- Schrager B
- Schroeder T
- Schulenburg D
- Schultz C
- Schulz M
- Schulze J
- Schulze U
- Schumacher M
- Schwartz A
- Schwerin G
- Schwerin M
- SchÀfer B
- Sciborski R
- Scott J
- Scott R
- Seals A
- Senni M
- Sergienko T
- Seroqui M
- Servaes V
- Sesto I
- Seung Kb
- Shah A
- Shah Av
- Shah J
- Shaikh P
- Shanahan T
- Shaposhnik I
- Shapovalova Y
- Sharma K
- Sharma T
- Sharp A
- Shatsky K
- Shaw P
- Shealy N
- Sheets L
- Shelley J
- Shepard P
- Shetty P
- Shimokawa H
- Shimomura H
- Shinozaki T
- Shvarts Y
- Sidhu G
- Siemann M
- Sigurdadottir E
- Sigurdsson A
- Silva R
- Silver K
- Simay A
- Sime I
- Simon J
- Simon M
- Simons N
- Simpson H
- Singerling M
- Singh K
- Singh N
- Singh V
- Singhal A
- Sinnaeve P
- Siostrzonek P
- Sirakova-Taseva A
- Sirnes Pa
- Sizemore Bc
- Skalicka H
- Skatrud L
- Skjelvan G
- Skopets I
- Skubova K
- Skuladottir F
- Skuratova M
- Slanina M
- Slapikas R
- Slayton C
- Slechticka A
- Slimak V
- Sloane G
- Smallwood B
- Smeele F
- Smik R
- Smith B
- Smith G
- Smith J
- Smith J
- Smith M
- Smith M
- Smith P
- Smith T
- Smith W
- Smith W
- Smolenskaya O
- Soca Y
- Socoteanu E
- Socoteanu G
- Sofley C
- Sohi Gs
- Solares A
- Soler J
- Solovev O
- Song M
- Sopko K
- Soro E
- Sorodoc L
- Sosa-Padilla M
- Sotolongo R
- Sotomayor A
- Soucy D
- Spiridon M
- Sprinkle B
- Squire I
- Srdos V
- Srinath Vs
- St Amour E
- Stahl A
- Stahl Hd
- Stanciulescu G
- Starzec M
- Stefanescu M
- Steinhoff J
- Stelly L
- Steringer-Mascherbauer R
- Stern M
- Sternthal P
- Stinson J
- Stitova M
- Stockhausen G
- Stockhausen J
- Stoddard M
- Stoessel J
- Stofkova D
- Stokuca-Korac N
- Stolze K
- Stone B
- Stonkute K
- Storey R
- Stover T
- Strain J
- Stratmann M
- Strazdiene D
- Strbova J
- Stroes E
- Strohner-Kaestenbauer H
- Stys T
- Sugimoto N
- Suleman A
- Sullivan P
- Sun Z
- Sundelin R
- Suorra I
- Sutalo K
- Suzuki A
- Swart Hp
- Szacinski G
- Szakal I
- Szatmarine V
- Szocs A
- Szpajer M
- Szymanowski N
- T Tase
- T Tekten
- T Thuren
- T Tjaden
- Taguchi S
- Tahk S
- Tahon S
- Takahashi J
- Takase S
- Talliard C
- Tamburrini P
- Tamesby G
- Tamez W
- Tan M
- Tan R
- Tanabe K
- Tanaka A
- Tanaseanu C
- Tandon N
- Tani S
- Taqueti V
- Taran A
- Taverner P
- Tawfik R
- Teenan M
- Telekes P
- Teltser M
- Ten Holt W
- Terry K
- Terry Ps
- Tesak M
- Teschner Ab
- Teske A
- Tessmar C
- Thakkar B
- Thekkoott D
- Theunissen E
- Thiessen S
- Thomas D
- Thomas Dm
- Thomas H
- Thompson E
- Thompson J
- Thornton A
- Tijuneliene E
- Tinnirello V
- Tisheva-Gospodinova S
- Tobias C
- Todorova A
- Tomassi A
- Tomioka J
- Toom M
- Topper J
- Torgersruud M
- Torstensson I
- Torun A
- Toth P
- Townend J
- Tran A
- Treasure C
- Trenkamp P
- Trevelyan J
- Trevino M
- Trofimov V
- Troquay Rpt
- Tsai Mc
- Tsao Hm
- Tsioufis K
- Tsorbatzoglou K
- Tsou L
- Tsuboi H
- Tsuji M
- Tsujita K
- Tsujiyama S
- Tudoran M
- Tuholske C
- Turner F
- Tusek S
- Tzekova M
- Tzong L
- Ucar N
- Uecker C
- Ueng Kc
- Umesu A
- Unterkircher B
- Urbonas G
- Uresin S
- Urgeova L
- Urina M
- Urina-Triana M
- Uy W
- V Vahula
- V Vijan
- V Vora
- Vahtel M
- Vaid B
- Valenzuela M
- Valle M
- Vallejo Ma
- Vallone L
- Van Der Wal M
- Van Der Zwaan C
- Van Genechten G
- Van Kempen Ww
- Van Maarseveen M
- Van Stein I
- Vanagiene S
- Vance A
- Vandam J
- Vanhecke T
- Vanness WC Iii
- Vardas P
- Vargas R
- Varigos J
- Vasiliev M
- Vaz S
- Vazquez Tanus J
- Veerina K
- Vega J
- VegsundvÄg J
- Veit S
- Velusamy K
- Vento A
- Venturini C
- Vertes G
- Vervoort G
- Vesely J
- Vesely P
- Vesga B
- Vettus R
- Veze I
- Vezikova N
- Vezina M
- Vibert J
- Vicente C
- Vico Ml
- Vida-Simiti L
- Vieira N
- Viergever Ep
- Viezelis M
- Vijay N
- Villani Gq
- Vinanska D
- Vincelli G
- Vins P
- Viola Hg
- Visseren Flj
- Vissers C
- Vitovec M
- Vodnansky P
- Voelker F
- Voeller H
- Vogel M
- Vogt E
- Vold D
- Volpe M
- Voors C
- Vora K
- Vorster M
- Voyzey Ej
- Vozzhaev A
- Vranckx P
- Vrolix M
- Vuriya Ak
- W Wu
- Wade Rd
- Wadell C
- Wakeling J
- Waksman R
- Walker K
- Walker K
- Wallace K
- Walter I
- Walter J
- Walther I
- Walukiewicz P
- Wanderley Ff
- Wang Cp
- Wang Hc
- Wang J
- Wang Y
- Wang Yl
- Warren M
- Washam M
- Watson B
- Webel R
- Weber Hg
- Wei J
- Wei N
- Weimer J
- Weisnagel Sj
- Wells T
- West M
- Westberg Jc
- Whitaker J
- White A
- White A
- White C
- White J
- Wichterich K
- Wiebusch A
- Wilhoit G
- Wilkins M
- Wilkinson S
- William M
- Willingham K
- Willmerdinger M
- Willner C
- Wilson S
- Wilson V
- Winkelmann B
- Winkler J
- Wise J
- Wistuba T
- Woehrle J
- Woelcke J
- Wohnlich T
- Wolf S
- Woodall S
- Woods A
- Woyczak D
- Wrage P
- Wright J
- Wu J
- Wu J
- Wujkowski M
- Wyss F
- Xavier Jp
- Xu H
- Xu Zj
- Yakovova S
- Yakushin S
- Yamada T
- Yamaguchi E
- Yamamoto H
- Yamamoto T
- Yamane M
- Yan J
- Yanase T
- Yanev T
- Yang Cc
- Yang K
- Yang P
- Yao Z
- Yaoqing H
- Yarows S
- Yasuoka S
- Yasutake M
- Yigit Z
- Yilmaz Mb
- Yim Kh
- Yim S
- Yokoyama M
- Yong H
- Yoshida M
- Yoshimoto E
- Yossen M
- Young A
- Younis L
- Youssef G
- Yuan Z
- Yunoki C
- Yupanqui H
- Z Zhai
- Z Zilahi
- Zadionchenko V
- Zadra R
- Zagozen P
- Zaidman C
- Zalazar L
- Zaman A
- Zangroniz P
- Zarate J
- Zareczky P
- Zarifis I
- Zdrenghea D
- Zebrack J
- Zena N
- Zhang J
- Zhang W
- Zhang Y
- Zhao R
- Zhou H
- Zidova M
- Zielinski M
- Zieve F
- Zineldine A.
- Zirlik A
- Zucchetti C
- Publication venue
- 'Massachusetts Medical Society'
- Publication date
- 01/01/2017
- Field of study
Background: Experimental and clinical data suggest that reducing inflammation without affecting lipid levels may reduce the risk of cardiovascular disease. Yet, the inflammatory hypothesis of atherothrombosis has remained unproved. Methods: We conducted a randomized, double-blind trial of canakinumab, a therapeutic monoclonal antibody targeting interleukin-1ÎČ, involving 10,061 patients with previous myocardial infarction and a high-sensitivity C-reactive protein level of 2 mg or more per liter. The trial compared three doses of canakinumab (50 mg, 150 mg, and 300 mg, administered subcutaneously every 3 months) with placebo. The primary efficacy end point was nonfatal myocardial infarction, nonfatal stroke, or cardiovascular death. RESULTS: At 48 months, the median reduction from baseline in the high-sensitivity C-reactive protein level was 26 percentage points greater in the group that received the 50-mg dose of canakinumab, 37 percentage points greater in the 150-mg group, and 41 percentage points greater in the 300-mg group than in the placebo group. Canakinumab did not reduce lipid levels from baseline. At a median follow-up of 3.7 years, the incidence rate for the primary end point was 4.50 events per 100 person-years in the placebo group, 4.11 events per 100 person-years in the 50-mg group, 3.86 events per 100 person-years in the 150-mg group, and 3.90 events per 100 person-years in the 300-mg group. The hazard ratios as compared with placebo were as follows: in the 50-mg group, 0.93 (95% confidence interval [CI], 0.80 to 1.07; P = 0.30); in the 150-mg group, 0.85 (95% CI, 0.74 to 0.98; P = 0.021); and in the 300-mg group, 0.86 (95% CI, 0.75 to 0.99; P = 0.031). The 150-mg dose, but not the other doses, met the prespecified multiplicity-adjusted threshold for statistical significance for the primary end point and the secondary end point that additionally included hospitalization for unstable angina that led to urgent revascularization (hazard ratio vs. placebo, 0.83; 95% CI, 0.73 to 0.95; P = 0.005). Canakinumab was associated with a higher incidence of fatal infection than was placebo. There was no significant difference in all-cause mortality (hazard ratio for all canakinumab doses vs. placebo, 0.94; 95% CI, 0.83 to 1.06; P = 0.31). Conclusions: Antiinflammatory therapy targeting the interleukin-1ÎČ innate immunity pathway with canakinumab at a dose of 150 mg every 3 months led to a significantly lower rate of recurrent cardiovascular events than placebo, independent of lipid-level lowering. (Funded by Novartis; CANTOS ClinicalTrials.gov number, NCT01327846.
Measurement of the WZ production cross section in pp collisions at root s=13 Tev
- Author
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- Abbaneo D
- Abbiendi G
- Abbrescia M
- Abdullah WATW
- Abdullin S
- Abdulsalam A
- Abercrombie D
- Abu Zeid S
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- Publication venue
- Publication date
- 01/01/2015
- Field of study
Peer reviewe
Relative Modification of Prompt psi(2S) and J/psi Yields from pp to PbPb Collisions at root(S)(NN)=5.02 TeV
- Author
- Aarrestad TK
- Abbaneo D
- Abbiendi G
- Abbrescia M
- Abdullah WATW
- Abdullin S
- Abdulsalam A
- Abercrombie D
- Abu Zeid S
- Ackert A
- Acosta D
- Acosta JG
- Acosta MV
- Adair A
- Adam W
- Adams JR
- Adams MR
- Adams T
- Adiguzel A
- Adzic P
- Afanasiev S
- Agapitos A
- Aggleton R
- Agram J-L
- Ahmad A
- Ahmad M
- Ahmad M
- Ahmed I
- Ahuja S
- Akbiyik M
- Akchurin N
- Akgun B
- Al-bataineh A
- Albergo S
- Albert A
- Albrow M
- Alcaraz Maestre J
- Alda Junior WL
- Alderweireldt S
- Aleksandrov A
- Alexander J
- Ali MABM
- Alimena J
- Allen B
- Almond J
- Alverson G
- Alves FL
- Alves GA
- Alyari M
- Amapane N
- Amin N
- Amsler C
- Anagnostou G
- Anampa KH
- Anderson D
- Anderson I
- Andrea J
- Andreev V
- Andreev Y
- Andrews MB
- Androsov K
- Anelli C
- Angioni GLP
- Antonelli L
- Antropov I
- Antunovic Z
- Apanasevich L
- Apollinari G
- Apresyan A
- Apyan A
- Arcaro D
- Arcidiacono R
- Arenton MW
- Argiro S
- Arleo F
- Arndt T
- Arneodo M
- Asavapibhop B
- Asawatangtrakuldee C
- Asilar E
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- Publication venue
- Publication date
- 04/11/2016
- Field of study
Peer reviewe
Observation of a New Excited Beauty Strange Baryon Decaying to Îb- Ï+Ï-
- Author
- Aarrestad TK
- Aarup Petersen H
- Abbaneo D
- Abbiendi G
- Abbrescia M
- Abdullin S
- Abercrombie D
- Abu Zeid S
- Acharya H
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- Acosta JG
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- AldĂĄ JĂșnior WL
- Aleksandrov A
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- Zabi A
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- Zahid S
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- Zalewski P
- Zanetti M
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- Zecchinelli AG
- Zeinali M
- Zeuner WD
- Zghiche A
- Zhang F
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- Zhizhin I
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- Zorbilmez C
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- Ălvarez FernĂĄndez A
- Ăzçelik Ă
- Publication venue
- American Physical Society
- Publication date
- 01/01/2021
- Field of study
The Îb-Ï+Ï- invariant mass spectrum is investigated with an event sample of proton-proton collisions at s=13 TeV, collected by the CMS experiment at the LHC in 2016-2018 and corresponding to an integrated luminosity of 140 fb-1. The ground state Îb- is reconstructed via its decays to J/ÏÎ- and J/ÏÎK-. A narrow resonance, labeled Îb(6100)-, is observed at a Îb-Ï+Ï- invariant mass of 6100.3±0.2(stat)±0.1(syst)±0.6(Îb-) MeV, where the last uncertainty reflects the precision of the Îb- baryon mass. The upper limit on the Îb(6100)- natural width is determined to be 1.9 MeV at 95% confidence level. The low Îb(6100)- signal yield observed in data does not allow a measurement of the quantum numbers of the new state. However, following analogies with the established excited Îc baryon states, the new Îb(6100)- resonance and its decay sequence are consistent with the orbitally excited Îb- baryon, with spin and parity quantum numbers JP=3/2-
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