11 research outputs found
Mental well-being among the oldest old: revisiting the model of healthy ageing in a Finnish context
- Author
- Publication venue
- 'Informa UK Limited'
- Publication date
- 01/01/2020
- Field of study
Purpose: This study aimed to examine how participants aged 80 years old or over describe their mental well-being-exploring the suitability of the model of healthy ageing when outlining the mental well-being concept.Methods: Six structured focus group interviews with 28 participants were conducted in Western Finland in 2017. Qualitative content analysis was performed, where both manifest and latent content was considered in a process involving meaning condensation and coding, followed by categorization.Results: The healthy ageing model constituted a useful framework for the conceptualization of mental well-being, illustrating the links between these two constructs. The analysis resulted in a four-dimensional model of mental well-being in oldest old age, the key components being: Activities-enjoyment and fulfilment; Capability-functioning and independence; Orientation-awareness, shifted perspectives and values; and Connectedness-sense of belonging.Conclusions: Although functional status plays an important role for well-being in general, it is not the principal component of self-reported mental well-being within the heterogeneous group of the oldest old. Further, many persons in this age group do not view themselves as passive or dependent, on the contrary, they underline the importance of empowering attitudes, a positive mindset and actively creating circumstances which support their mental well-being
Design and baseline characteristics of the finerenone in reducing cardiovascular mortality and morbidity in diabetic kidney disease trial
- Author
- Abdel-Rahman Emaad
- Abhayaratna Walter
- Abramof Ness Rosane
- Acosta Idalia
- Adams Atoya
- Adawi Faiad
- Adler Sharon
- Ahmed Fayzal
- Aizenberg Diego
- Ajani Dilawar
- Al-Karadsheh Amer
- Albota Adrian
- Alferi Dino
- Alicic Radica
- Alla Sreedhara
- Allison D
- Almeida Edgar
- Alpizar Salazar Melchor
- Amer Joseph
- Amod Aslam
- Andrawis Nabil
- Antonio Bossi Carlo
- Antsiferov Mikhail
- Antunes Daniela
- Araki Hideo
- Arango Clara
- Arcos Edgar
- Arif Ahmed
- Arif Imrozia
- Arkhipov Mikhail
- Armaly Zaher
- Aroca Gustavo
- Asprusten Emil
- Atar Shaul
- Avila Pardo Sandro
- Awad Ahmed
- Axthelm Christoph
- Azizad Masoud
- Azizah Aziz Nor
- B Brouwer C
- Babikova Jana
- Babkin Andrey
- Badak Ozer
- Bahrami Michael
- Bajcsi Dora
- Baker John
- Bala Cornelia
- Ballesteros Rosa
- Bansal Shweta
- Barag Steven
- Barakzoy Ahmad
- Baranov Vitaliy
- Barbarash Olga
- Barbonta Hortensia
- Barney Mark
- Barre Paul
- Barrera Sandra
- Barreto Carlos
- Barreto Germ\ue1n
- Bartolacci In\ue9s
- Bashir Khalid
- Bashkin Amir
- Bastidas Adrian Miriam
- Bautista Albert
- Bautista Jose
- Bech Jesper
- Beddhu Srinivasan
- Beltr\ue1n L\uf3pez Nelly
- Ben Chetrit Sydney
- Benitez Diego
- Benjamin Sabrina
- Berar Yanay Noa
- Berenji Ramin
- Bertram Pitt
- Bertsch John
- Besada Diego
- Bhana Sindeep
- Bhargava Anuj
- Bilz Stefan
- Birkenfeld Andreas
- Birriel Jose
- Bittar Julio
- Blanco Guillermo
- Bleich David
- Boletis Ioannis
- Bondarets Iryna
- Bonora Enzo
- Bornfreund Jonathan
- Boshnyashka Radostina
- Botelho Roberto
- Botero Rodrigo
- Botsyurko Volodymyr
- Bouarich Hanane
- Brada Michal
- Brandao Ilidio
- Brar Harjeet
- Braun Hermann
- Brezina Jiri
- Brian Susan
- Brietzke Stephen
- Brito Claudia
- Bruchfeld Annette
- Bruno Giorda Carlo
- Brusco Osvaldo
- Bu Ruifang
- Bucek Petr
- Buganova Ingrid
- Burgner Anna
- Busch Klaus
- Busch Robert
- Butrymowicz Patrycja
- C Bakker R
- C\ue1rdenas Tatiana
- Caceaune Elena
- Cai Hanqing
- Calabr\uf2 Paolo
- Calero Francesca
- Canadas Rafael
- Canani Luis
- Caramori Maria
- Cardona Jose
- Cariou Bertrand
- Carlo Maggi Davide
- Carlos Palma Juan
- Carlos Prieto Juan
- Carlson Brian
- Carpio Jose
- Carvalho Rui
- Case Christopher
- Castro Cristina
- Catindig Elizabeth
- Catrinoiu Doina
- Cayli Murat
- Cereto Castro Fernando
- Cerqueira Maria
- Chahin Mariano
- Chang Chiz-Tzung
- Chantrel Fran\ue7ois
- Chen Dejun
- Chen Nan
- Chen Qinkai
- Cheng Jinluo
- Chernikova Viktoriia
- Chernin Gil
- Chernyavskaya Elena
- Chew Wong Alfredo
- Christina Nowack
- Chuang Lee-Ming
- Chung ChoonHee
- Ciechanowski Kazimierz
- Cieslik Grazyna
- Cigarr\ue1n Guldris Secundino
- Cimino Roberto
- Clavel Sylvaine
- Clodi Martin
- Cobos Jorge
- Colman Peter
- Colquhoun David
- Constantin Ciprian
- Contzen Christel
- Conway James
- Coronel Julian
- Cortes-Maisonet Gregorio
- Cortes-Maisonet Gregorio
- Cournoyer Serge
- Crawford Veronica
- Cristina Gregorini Maria
- Cruz Humberto
- Cruzado Garrit Josep
- Cure Carlos
- Curiac Dan
- Cutfield Rick
- Dandillaya Ramprasad
- Dang Cuong
- Danos Peter
- Darawsha Mahmud
- de \uc1lvaro Fernando
- de Paula Rogerio
- Deerochanawong Chaicharn
- Degenhardt Stefan
- Demko Arkadiy
- Derwahl Karl
- Dhanireddy Soni
- Din Zia
- Distiller Larry
- Dixon Bradley
- Dolores Mart\uednez Esteban M\uaa
- Donath Marc
- Donets Oleksandra
- Dong Junwu
- Dong Youping
- Doshi Ankur
- Doubel Peter
- Dreval Alexander
- Drexel Heinz
- Du Yuming
- Dumas Richard
- Dumitrescu Adriana
- Dunn Peter
- Dur\ue1n Carlos
- Duyck Francis
- Dzupina Andrej
- E Costa Fernando Teixeira
- Ebenbichler Christoph
- Ebisui Osamu
- Edelsberger Tomas
- Edin Anton
- Eduardo Figueiredo Carlos
- Eduardo Salles Joao
- Efrati Shai
- Ekinci Elif
- El Shahawy Mahfouz
- El-Shahawy Mohammed
- Elbert Alicia
- Elias Mazen
- Eliaschewitz Freddy
- Eliasson Ken
- Emdin Michele
- Engelen Wendy
- Eren Necmi
- Eriksen Erik
- Ermakova Polina
- Escalada San Mart\uedn Javier
- Escobedo de la Pe\uf1a Jorge
- Esteves Cesar
- Eugenia Canziani Maria
- Eustace Joe
- Evans John
- Faber Jens
- Fadda George
- Fang Sum Chee
- Fang Yi
- Fangh\ue4nel Salm\uf3n Guillermo
- Farah Ghassan
- Farber Evgeny
- Farooq Umar
- Fauvel Jean-Pierre
- Fernando Roland
- Fiaccadori Enrico
- Fikry Sameh
- Fink Raymond
- Finnes Trine
- Fiorina Paolo
- First Brian
- Fitz-Patrick David
- Flack John
- Fliesser-G\uf6rzer Evelyn
- Fluck Patrick
- Fogelfeld Leon
- Fonseca Vivian
- Forti Adriana
- Franek Edward
- Frank Malin
- Frias Juan
- Fujita Naruhiro
- Furuya Ryuichi
- Fushtey Ivan
- G Lieverse A
- Galcer\ue1n Josep
- Gallouj Karim
- Galphin Claude
- Galyavich Albert
- Gansevoort Ron
- Garc\ueda Hern\ue1ndez Pedro
- Garc\ueda Luis
- Garcia-Mayol Luis
- Gaysina Leyla
- Gelersztein Elizabeth
- George L Bakris
- Georgiev Dimitar
- Gerasimos Filippatos
- Giebel Thomas
- Gillard Pieter
- Giorgio Battaglia Giovanni
- Gislason Gunnar
- Glandt Mariela
- Goldstein Gary
- Goluch Richard
- Gonz\ue1lez Albarr\ue1n Olga
- Gonz\ue1lez G\ue1lvez Guillermo
- Gonz\ue1lez Gonz\ue1lez Jos\ue9
- Gonz\ue1lez Fernando
- Gonzalez Edgar
- Gonzalez-Abreu Francisco
- Gordeev Ivan
- Gore Ashwini
- Gouet Didier
- Grachova Mariia
- Grant David
- Grossman Ehud
- Guan Tianjun
- Guerci Bruno
- Guerrot Dominique
- Guia Jose
- Gul Ibrahim
- Gulakova Drahomira
- Gumprecht Janusz
- Guo Weiying
- Guron Gregor
- Gushterova Valentina
- Guti\ue9rrez Ochoa Ramiro
- Guzm\ue1n Gustavo
- H Boonstra A
- H\uf8ivik Hans
- Habwe Violet
- Hagemeier Robert
- Hagenow Andreas
- Halabi Majdi
- Haller Hermann
- Halpern Stephen
- Hamamoto Yoshiyuki
- Hamasaki Akihiro
- Hamet Pavel
- Hamilton Maxine
- Hammoud Jamal
- Handelsman Stuart
- Hangaard J\uf8rgen
- Hanna Fahmy
- Hanusch Ursula
- Hao Chuanming
- Harcsa Eleonora
- Hart Randolph
- Hartman Israel
- Hasalova Zapletalova Jitka
- Hasnul Halimi Bin Wan Hasan Wan
- Hasslacher Christoph
- Hatazaki Masahiro
- Hatunic Mensud
- Hatziagelaki Erifili
- Hayashi Terumasa
- Heigerick Glenn
- Heitor Susana
- Hellberg Olof
- Hellgren Margareta
- Henein Sam
- Hern\ue1ndez Jaras Julio
- Hern\ue1ndez Eric
- Hernandez German
- Hernandez-Cassis Carlos
- Herrera Carlos
- Higashi Takayuki
- Hirohata Yoshihide
- Hissa Miguel
- Hoffmann Michal
- Hola Olga
- Holian John
- Honkasalo Mikko
- Honkasalo Mikko
- Horacek Thomas
- Horinouchi Shuji
- Hornova Lucie
- Houdova Jana
- Hougardy Jean-Michel
- Hrmova Helena
- Humaloja Kari
- Hung Cheng-Chieh
- Hwang YouCheol
- Ibarra Jaime
- Ibern\uf3n Meritxell
- Imoto Hirofumi
- Inagaki Akemi
- Inagaki Masayuki
- Ioannidis Ioannis
- Ipatko Irina
- Iranmanesh Ali
- Irizar Santana Sa\ufal
- Isayeva Anna
- Ishii Masao
- Ishiko Tamayo
- Jackson Timothy
- Jain Mahendra
- Jamerson Kenneth
- Jansen van Rensburg Dirkie
- Jaramillo Carlos
- Jaramillo Nicol\ue1s
- Jaroslaw Pacyk Grzegorz
- Jiang Fangfang
- Jiang Ju-Ying
- Jiang Sheng
- Jinnouchi Hideaki
- Johnson Karen
- Joshi Mukesh
- Joshi Shaifali
- Juhl Claus
- Juli\ue1n Segura de la Morena Jos\ue9
- Jungmair Wolfgang
- Kahal Hassan
- Kalashnikova Marina
- Kalathil Dhanya
- Kalina Akos
- Kanai Hidetoshi
- Kananen Kristiina
- Kanda Daisuke
- Kanehara Hideo
- Kang JunGoo
- Kantola Ilkka
- Karasek David
- Karlsson Thomas
- Kashima Masayuki
- Kato Kiyoe
- Katsuki Takeshi
- Kattah William
- Kawamitsu Katsunori
- Kawasaki Satsuki
- Kayali Zeid
- Kaye William
- Kazup Szilvia
- Kelly Allan
- Keltai Katalin
- Khalimov Yuriy
- Khan Bobby
- Khan Muhammad
- Khanh Tran
- Kharait Sourabh
- Kikuchi Fumi
- Kikuchi Hidetoshi
- Kilvert Anne
- Kim HyeSoon
- Kim InJoo
- Kim JaeHyeon
- Kim SinGon
- Kirschner Robert
- Kiss Julianna
- Klein Alexandre
- Klimontov Vadim
- Kloos Christof
- Klyuchkova Neli
- Kobalava Zhanna
- Kobayashi Kunihisa
- Koch Stanley
- Koch Thorsten
- Kocyigit Ismail
- Kogut Dmytro
- Koide Junko
- Koistinen Arvo
- Komisarenko Julia
- Kooy Adriaan
- Kopecka Sarka
- Kopyt Nelson
- Korff Gary
- Korsoff Pirkko
- Kosachunhanan Natapong
- Kosmacheva Elena
- Kotzker Wayne
- Kounadi Theodora
- Kovacs Laszlo
- Kovar Richard
- Kovesdy Csaba
- Koziolova Natalya
- Kr\ufcger Thilo
- Krarup Thure
- Kravchun Nonna
- Krcova Eva
- Krebs Jeremy
- Kreit Camil
- Krekels Marielle
- Kriauciuniene Dovile
- Krishna Arvind
- Kronfli Saeed
- Krzykowska Jolanta
- Kuang Jian
- Kubota Miyuki
- Kuchar Jiri
- Kumbasar Abdulbaki
- Kurnatowska Ilona
- Kusano Yoshiro
- Kutejova Vlasta
- Kvitkova Lyudmila
- Kyriakidou Christina
- L Penne E
- L\uf3pez M\uf3nica
- L\uf6ndahl Magnus
- La Manna Gaetano
- Lahtela Jorma
- Laimer Markus
- Lakha Deepak
- Lamboy Beata
- Landa Katarzyna
- Larnefeldt Hans
- Lasiene Jurate
- Lazcano Soto Jos\ue9
- LE Meur Yannick
- Lee ByungWan
- Lee Chien-Te
- Lee Keung
- Lee Paul
- Lee WooJe
- Lei Minxiang
- Leite Jr Maurilo
- LeJeune Derek
- Lemus Brenda
- Lerman Sam
- Levashov Sergey
- Li Dongmei
- Li Hongmei
- Li Jingmei
- Li Ling
- Li Yan
- Li Yuxiu
- Li Zhonghe
- Li\ue9vano Manuel
- Liberman Alberto
- Liberty Idit
- Libis Roman
- Lim Soo
- Lindhardt Morten
- Lindholm Carl-Johan
- Linfert Douglas
- Literati-Nagy Botond
- Liu Fang
- Liu Jian
- Liu Yinghong
- Liu Yuantao
- Liu Zhihong
- Liutkus Joanne
- Long Gang
- Loong Loh Chek
- Lora Henry
- Lu Guoyuan
- Lu Weiping
- Lu Yibing
- Lubanda Hana
- Lucheva Mariya
- Ludvik Bernhard
- Luigi Cavalot Franco
- Luis M Ruilope
- Lurie Alexander
- M Barendregt J N
- M van Leendert Ruud J
- M\ue9ndez Machado Gustavo
- M\ufcller Joachim
- Ma Jianhua
- MacIsaac Richard
- Maddukuri Geetha
- Madero Rovalo Magdalena
- Madore Francois
- Madrzejewski Adam
- Madsbad Sten
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- Magno Alexander
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- Maletz Louis
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- Malykh Natalia
- Malyutina Sofya
- Mandayam Sreedhar
- Mandviwala Mustafa
- Mankovsky Borys
- Mann Mah Peak
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- Mar\ueda Pascual Izuel Jos\ue9
- Marasaev Vyacheslav
- Mareev Vyacheslav
- Maria Veronelli Anna
- Markell Mariana
- Mart\uednez Deben Francisco
- Martin Earl
- Martinho Valdemar
- Martins Judith
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- Martynyuk Liliya
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- Matos Pedro
- Matsubayashi Sunao
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- Medina Marcelo
- Meisner Carl
- Melo Pedro
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- Meyer Jill
- Mich\ue1n Alfredo
- Mileder Margit
- Min Cho Young
- Mindrescu Nicoleta
- Minh Nui Nguyen
- Minkova Dotska
- Minton Stephen
- Mirasol Roberto
- Mistodie Cristina
- Mitha Essack
- Miyaoka Hiroaki
- Mkrtumyan Ashot
- Mo Zhaohui
- Mocherla Bharat
- Mohamad Masni
- Mohd Ali Norhaliza
- Mohd Izani Wan Mohamed Wan
- Mokrejsova Magdalena
- Molina Dora
- Mong Bee Yong
- Monier Arnaud
- Montero Manuel
- Moranne Olivier
- Morita Takeshi
- Mosenzon Ofri
- Moustafa Moustafa
- Murao Satoshi
- Myshanych Halyna
- Myung Yu Jae
- Nadkarni Salil
- Nagy Laszlo
- Najme Khir Rizmy
- Nakayama Mikihiro
- Nakazawa Jun
- Nakhle Samer
- Napora Piotr
- Navarro Jesus
- Navickas Antanas
- Nechaeva Galina
- Negrisanu Gabriela
- Nelson Craig
- Neudorfer Peter
- Nevarez Ruiz Luis
- Neyra Nilda
- Ngoc Nguyen Boi
- Nguyen Son Pham
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- Nicol Philip
- Nicole Mentenich
- Nielsen Joan
- Nieminen Sakari
- Nieminen Tuomo
- Nikolaev Konstantin
- Nimer Assy
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- Nirmalaraj Kingsley
- Nischik Ruth
- Niu Jianying
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- Nomiyama Takashi
- Nonchev Boyan
- Noori Ebrahim
- Noritake Masayuki
- Noronha Irene
- Norwood Paul
- Nowicki Michal
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- Nur Fatnoon Nik Ahmad Nik
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- O Donovan Richard
- O Keefe Dennis
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- Ochodnicka Zuzana
- Ocicka-Kozakiewicz Anna
- Odugbesan A
- Ogiwara Takayuki
- Oguz Aytekin
- Ohashi Hiroshi
- Okamoto Hideki
- Okenka Libor
- Oliver David
- Onaca Adriana
- Oparil Suzanne
- Osonoi Takeshi
- Ozdogan Oner
- P\ue9rez Manghi Federico
- Packham David
- Palyutin Shamil
- Pamugas Glenda
- Pang Ip Tai
- Pani Antonello
- Paoli-Bruno Jorge
- Paolino Bruno
- Papadopoulou Dorothea
- Papagianni Aikaterini
- Pape Alexia
- Paschoalin Nathalia
- Paschoalin Raphael
- Pascual Santos Julio
- Passadakis Ploumis
- Patel Rajesh
- Patel Rakesh
- Paulweber Bernhard
- Paveliu Silvia
- Pech\ue8re-Bertschi Antoinette
- Pecoits Filho Roberto
- Pedersen-Bjergaard Pedersen-Bjergaard Ulrik
- Peixoto Aldo
- Peng Ai
- Pereira Amalia
- Pereira Marcio
- Pererva Larysa
- Pergola Pablo
- Perico Norberto
- Pertseva Nataliia
- Peter Kolkhof
- Peterson Sean
- Petro Gizella
- Pettis Karlton
- Pf\ufctzner Andreas
- Phi Kon Sui
- Phuong Tran Lan
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- Pichmanova Mariyana
- Pimenov Leonid
- Pintilei Ella
- Pisani Antonio
- Pisoni Roberto
- Pistrosch Frank
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- Podgorski Gracjan
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- Ponduchi Mirela
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- Popeil Larry
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- Prager Rudolf
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- Prazny Martin
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- Prei f Wolfgang
- Prischl Friedrich
- Pumprla Jiri
- R Winkelmann Bernhard
- Radulian Gabriela
- Radzeviciene Lina
- Raina Rupesh
- Rajiv Agarwal
- Ramanathan Kodangudi
- Ramos L\uf3pez Gabriel
- Ramos-Gonez Luis
- Rangelov Rangel
- Ranjith Naresh
- Rashkov Rosen
- Rasmussen Ole
- Rastogi Anjay
- Ratnasingam Jeyakantha
- Rayner Brian
- Rea Rosangela
- Rechkova Elena
- Red\uf3n Josep
- Reddan Donal
- Rein-Hedin Erik
- Reisin Efrain
- Rendell Marc
- Rewerska Barbara
- Reyes Eliana
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- Rice Sam
- Riella Miguel
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- Rossing Peter
- Rothman Jeffrey
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- Rudolph Lance
- Ruhullah Yusuf
- Rump Lars
- Ruoff Gary
- Rusicka Teresa
- Ruxer Jan
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- Ryu Jeffrey
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- Saavedra Victor
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- Salda\uf1a Mendoza Arturo
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- Sasaki Nobuhiro
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- Saxena Sanjeev
- Sch\uf6ll Norbert
- Sch\uf6nherr Hans-Robert
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- Schernthaner Gerit-Holger
- Schettler Volker
- Schiefke Ingolf
- Schlichthaar Heike
- Schneider Karoly
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- Schr\uf6ppel Bernd
- Schwartz Daniel
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- Seeber Mary
- Sekigami Taiji
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- Semenova Olga
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- Seron Daniel
- Serota Harvey
- Serusclat Pierre
- Shafi Tariq
- Shahid Nauman
- Shanik Michael
- Sharma Santosh
- Shen Feixia
- Shen Jiansong
- Sherenkov Alexander
- Shi Bingyin
- Shibasaki Taro
- Shibata Hirotaka
- Shinoda Junji
- Shu Daniel
- Siebert Heidi
- Sigal Helena
- Silva Ana
- Silva Gil
- Simon Judit
- Sinha Arjun
- Skokowska Ewa
- Smelser James
- Smirnov Ivan
- Smith Mark
- Smolyarchuk Elena
- Smuts Nine
- Sobajima Hiroshi
- Soe Kyaw
- Sokolova Liubov
- Solache Ortiz Gustavo
- Soln\uf8r Leidulv
- Solomon Richard
- Solovev Oleg
- Soroka Eugene
- Sosovec Dalibor
- Soto Alfonso
- Soufer Joseph
- Sourij Harald
- Soveri Inga
- Spaak Jonas
- Speeckaert Marijn
- Spodniakova Denisa
- Sritara Piyamitr
- Stanchev Pavel
- Stankiewicz Andrzej
- Stas Koen
- Steele Andrew
- Stefan D Anker
- Stefanidis Ioannis
- Stemler Lutz
- Stephenson Hugo
- Stompor Tomasz
- Stoyanovska-Elencheva Bilyana
- Strack Georg
- Strand Jorma
- Strey Christopher
- Strongin Leonid
- Stryzhak Vasyl
- Su Qing
- Suarez Rosa
- Subramanian Bala
- Sue Kirkman M
- Sugitatsu Kazuya
- Sugiura Toshiyuki
- Sugiyama Toru
- Sulosaari Sakari
- Sun Zhuxing
- Suranyi Michael
- Suzuki Daisuke
- Suzuki Masaaki
- Swift Pauline
- Szerlip Harold
- Szilagyi Iosif
- Szocs Albert
- T Luik P
- T\ue4schner Heidrun
- Tagarev Zhivko
- Tamirisa Aparna
- Tanaka Asami
- Tanaka Seiichi
- Tang Shuifu
- Tanque Maribel
- Tarng Der-Cherng
- Tavli Talat
- Tayob Mohammed
- Teitelbaum Ivor
- Tellier Guy
- Temelkova-Kurktschieva Theodora
- Temizhan Ahmet
- Tengmark Bengt-Olov
- Tennankore Karthik
- Terront M\uf3nica
- Thomson Stephen
- Thorup Frode
- Tigen Mustafa
- Tirador Louie
- Tiuryn-Petrulewicz Agnieszka
- Tobe Sheldon
- Tomanek Pavel
- Tong Nanwei
- Tonolo Giancarlo
- Topliss Duncan
- Toursarkissian Nicole
- Tran Tuan-Huy
- Treger Richard
- Trevisan Roberto
- Trokis J
- Troya Maribel
- Trujillo Freddy
- Trullenque Gretel
- Tsch\uf6pe Diethelm
- Tsoukas George
- Tsunematsu Izumi
- Tu Shih-Te
- Turcu Liana
- Turk Thomas
- Tytus Richard
- Ujihara Makoto
- Ukhanova Olga
- Ulmer Achim
- Umpierrez Guillermo
- Urbach Daniel
- Urbach Dorothea
- Urbanaviciene Egle
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- Urina Miguel
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- Vacaru Georgeta
- Valdes Martin
- Valdez Ortiz Rafael
- Valika Shujauddin
- Vallejos Augusto
- van Buren M
- van den Born Bert-Jan
- van der Giet Markus
- VAN Gaal Luc
- VAN Hoang Lam
- van Zyl Louis
- Vanbelleghem Hilde
- Vandeleur James
- Varleta Paola
- Vasas Szilard
- Vasconcellos Eduardo
- Vasileva Svetla
- Vega Damaris
- Velaviciene Audrone
- Vencio Sergio
- Verges Bruno
- Verlan Nadezhda
- Vi\uf1es Gloria
- Vijayaraman Arutchelvam
- Vila Lobos Ana
- Villagordoa Mesa Juan
- Villegas Iv\ue1n
- Vitou Louise
- Vlad Adrian
- Vlasenko Maryna
- Vorokhobina Natalya
- Wainstein Julio
- Wainstein Julio
- Walsh Michael
- Wan Ronald Ma Ching
- Wang Hao
- Wang Jianqin
- Wang Li
- Wang Lihua
- Wang Xinjun
- Wanner Christoph
- Wasilewska Katarzyna
- Wassermann Alfredo
- Wei Jiali
- Weisnagel Stanley
- Weissman Peter
- Whaley-Connell Adam
- Wierusz-Wysocka Bogna
- Wilderman Igor
- Winston Jonathan
- Wise Jonathan
- Wittert Gary
- Wnetrzak-Michalska Renata
- Wong Yuk-Ki
- Wu Chaoqing
- Wu Mai-Szu
- Wu Ming-Ju
- Wu Tianfeng
- Wudi Krisztina
- Wuerzner Gregoire
- Wynne Katie-Jane
- Xing Changying
- Xiong Fei
- Xu Ning
- Xu Xudong
- Yagil Yoram
- Yajima Ken
- Yakhontov Davyd
- Yale Jean-Francois
- Yamada Daishiro
- Yamada Masayo
- Yamagata Kazuo
- Yamakawa Fumiko
- Yamakawa Ken
- Yamasaki Yoshimitsu
- Yambe Yuko
- Yanai Hidekatsu
- Yang Jinkui
- Yasuda Tetsuyuki
- Yenicerioglu Yavuz
- Yeung Vincent
- Yilmaz Huseyin
- Yin Aiping
- Yoncheva-Mihaylova Mariana
- Young Park Cheol
- Yuan Lee Li
- Yupanqui Hern\ue1n
- Yuryev Michael
- Zakharova Elena
- Zalevskaya Alsu
- Zanozina Olga
- Zaoui Philippe
- Zeig Steven
- Zeng Longyi
- Zhang Hao
- Zhang Yanlin
- Zhang Ying
- Zhao Zhiquan
- Zhdanova Elena
- Zheng Hongguang
- Zhong Ling
- Zhong Liyong
- Zhu Dalong
- Zhukova Larisa
- Zilahi Zsolt
- Zsom Marianna
- Zukermann Robert
- Zykova Tatyana
- Publication venue
- 'S. Karger AG'
- Publication date
- 01/01/2019
- Field of study
Background: Among people with diabetes, those with kidney disease have exceptionally high rates of cardiovascular (CV) morbidity and mortality and progression of their underlying kidney disease. Finerenone is a novel, nonsteroidal, selective mineralocorticoid receptor antagonist that has shown to reduce albuminuria in type 2 diabetes (T2D) patients with chronic kidney disease (CKD) while revealing only a low risk of hyperkalemia. However, the effect of finerenone on CV and renal outcomes has not yet been investigated in long-term trials.
Patients and Methods: The Finerenone in Reducing CV Mortality and Morbidity in Diabetic Kidney Disease (FIGARO-DKD) trial aims to assess the efficacy and safety of finerenone compared to placebo at reducing clinically important CV and renal outcomes in T2D patients with CKD. FIGARO-DKD is a randomized, double-blind, placebo-controlled, parallel-group, event-driven trial running in 47 countries with an expected duration of approximately 6 years. FIGARO-DKD randomized 7,437 patients with an estimated glomerular filtration rate >= 25 mL/min/1.73 m(2) and albuminuria (urinary albumin-to-creatinine ratio >= 30 to <= 5,000 mg/g). The study has at least 90% power to detect a 20% reduction in the risk of the primary outcome (overall two-sided significance level alpha = 0.05), the composite of time to first occurrence of CV death, nonfatal myocardial infarction, nonfatal stroke, or hospitalization for heart failure.
Conclusions: FIGARO-DKD will determine whether an optimally treated cohort of T2D patients with CKD at high risk of CV and renal events will experience cardiorenal benefits with the addition of finerenone to their treatment regimen.
Trial Registration: EudraCT number: 2015-000950-39; ClinicalTrials.gov identifier: NCT02545049
Large expert-curated database for benchmarking document similarity detection in biomedical literature search
- Author
- Aanei Carmen M.
- Abid Muhammad B.
- Abramowitz Matthew K.
- Abu-Zaid Ahmed
- Adamo Vincenzo
- Adeyemo Adebolajo A.
- Afnan Masoud
- Agarabi Cyrus
- Aggelidou Maria
- Ahmad Haroon
- Ahmad Rafi
- Aizat Wan M.
- Ajani Penelope A.
- Akinwumi Sayo A.
- Al-Farha Abd A.
- Al-Lawama Manar
- Al-Owaifeer Adi M.
- Al-Riyami Arwa Z.
- Alanio Alexandre
- Alaux Cedric
- Albery Gregory F.
- Albiol Joan
- Albrecht Dirk R.
- Albuquerque Lucia G.
- Alhowimel Ahmed
- Ali Junaid
- Alimba C.G.
- Allardyce Judith
- Almeida Gabriel M.F.
- Alonso-Caneiro David
- Alper Ozgul M.
- Alshehri Mansour
- Alsuhaibani Mohammed
- Alzghari Saeed K.
- Amer Said E.D.R.
- Amir Shimon
- Amiya Eisuke
- Ammerman Brooke A.
- Amorim Rogerio M.
- An Qianli
- Anazodo Udunna C.
- Andersen Stig U.
- Andersen Vibeke
- Angus Kathryn
- Anikin Andrey
- Aplin John D.
- Argyropoulos Christos
- Armitage Charles
- Asaduzzaman Muhammad
- Asady Hadi
- Ascher David B.
- Ashry Mohamed
- Asmann Yan W.
- Assaeed Abdulaziz M.
- Atack John M.
- Atanasov Atanas G.
- Atchison David A.
- Atkins Gerald J.
- Atlas Lauren
- Ato Dai
- Avery Simon V.
- Avillach Paul
- Azubuike Samuel O.
- Baade Peter D.
- Bach-Mortensen Anders
- Backman Lars
- Badie Christophe
- Bae Taeok
- Bagloee Saeed Asadi
- Bai Xiaoyong
- Baier Dirk
- Bail Kasia
- Baines Rebecca L.
- Baker Chris I.
- Bakkach Joaira
- Baldi Alfonso
- Ball Elizabeth
- Ballantyne Maghan
- Baltiansky Lior
- Ban Bo
- Bannon Ross
- Bansal Abhisheka
- Bar Ido
- Bardot Olivier
- Barnett Adrian G.
- Barraud Pierre
- Bartas Martin
- Basharat Zarrin
- Basner Mathias
- Bathelt Joe
- Batra Jyotsna
- Baumert Philipp
- Bazanova O.M.
- Beale Andrew
- Beck Charles R.
- Beck Jill
- Becker Daniel
- Beddoe Travis
- Belachew Kiflemariam Y.
- Bell Melanie L.
- Ben-Nafa Walid
- Benezeth Yannick
- Bengtsson-Palme Johan
- Benkeser David
- Berbesque Colette
- Berezikov Eugene
- Bergsland Niels
- Berners-Price Sue
- Bernhardt Peter
- Bernier Meghan L.
- Berrevoet Frederik
- Berry Edward
- Berthold Maximilian
- Bessa Theolis B.
- Beyene Tariku J.
- Bhardwaj Vivek
- Biedermann Peter H.W.
- Bijleveld Erik
- Billington Craig
- Binder Karin
- Birch John
- Bittner Florian
- Bitzer Michael
- Black Emma
- Blakely Randy D.
- Blanchard Adam M.
- Blancher Antoine
- Blanck Oliver
- Bland Nicholas S.
- Blankstein Ron
- Blaskovich Mark A.T.
- Bleackley Mark
- Blombach Fabian
- Blum Robert
- Boah Michael
- Boakye Dominic W.
- Bodagh Neil
- Boehme Karen A.
- Boelaert Marleen
- Bogdanos Dimitrios
- Bonatsos Vasileios
- Bonvin A.M.J.J.
- Boon Michele H.
- Borges Paulo
- Bosch Carles
- Bosch Oliver
- Bouboulis George
- Boudreau Shellie A.
- Bourgoin Thierry
- Bourke Emer
- Bouvard Daniel
- Boykin Laura M.
- Br\ufchl Albert
- Bradley Graeme
- Bradshaw William
- Bramoweth Adam D.
- Brand Thomas
- Braubach Oliver
- Braun Daniel
- Braun R. J.
- Brenneisen Peter
- Bridges Kristina M.
- Bromfield Elizabeth
- Brooks Anastasia
- Brown James A.L.
- Brown Joshua
- Brown Peter
- Browngardt Christopher
- Brownlie Jeremy
- Brox-Ponce Josue
- Brunetti Arturo
- Bukowy-Bieryllo Zuzanna
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- Butkowski Eugene G.
- Butler Lisa M.
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- Byrne Hugh J.
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- Cai Yufeng
- Calabr\uf2 Giovanna E.
- Calatayud Sara
- Callahan Tiffany J.
- Campana Luca G.
- Campbell Matthew
- Candal Eva
- Canham Colin D.
- Cao Bing
- Cao Zanxia
- Cao Zehong
- Cardoso Pedro
- Carlson Kimberly
- Carninci Piero
- Carroll Grace
- Carter Dee
- Carvajal Richard
- Cascella Marco
- Casillas S\uf2nia
- Castelvetro Valter
- Caswell Patrick T.
- Catry Thibault
- Cavalli Giacomo
- Cernava Tomislav
- Cerovsky Vaclav
- Ch\ue1vez-Fumagalli Miguel A.
- Chacko George
- Chagoyen Monica
- Chakraborty Sayan
- Chalmers Kelsey
- Chan Sherwin S.
- Chandrasekaran Arun R.
- Chang Shun C.
- Chang Wei
- Chao Fengqing
- Chao Jie
- Charrier Elisabeth E.
- Chatterjee Pranab
- Chatzitheochari Stella
- Che Zhengping
- Chen Andrew T.Y.
- Chen Branson
- Chen Chang-Er
- Chen Chang-Shi
- Chen Dong F.
- Chen Haimin
- Chen Hao
- Chen He
- Chen Huaming
- Chen Hui
- Chen Jui-Tung
- Chen Liming
- Chen Xiaoyin
- Chen Xin
- Chen Yi-Chun
- Chen Yinglong
- Chen Youning
- Chen Yu-Chih
- Chen Zhao
- Cheng Changxiu
- Cheng Jianlin
- Cheng Shuiqin
- Chenguang [NO FIRST NAME IN SCOPUS]
- Cheung Johnny T.K.
- Chhatriwalla Adnan K.
- Chikowe Ibrahim
- Chinapaw Mai
- Chinopoulos Christos
- Cho William C.S.
- Choi Jane R.
- Choi Youngrok
- Chong Lillian
- Chowdhury Debashish
- Chowdhury Mohiuddin A.K.
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- Christoffersen Tore
- Chuang Trees-Juen
- Chung Hee-Jung
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- Ciresi A.
- Cobine Paul A.
- Cockcroft Shamshad
- Coelho Luis P.
- Colella Vito
- Collevatti Rosane G.
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- Cooke Robert S.C.
- Cooper David N.
- Cooper Jeffrey
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- Cosse Cyril
- Costa Antonio
- Costa Bruno M.
- Costa Elisio
- Costa Vincent D.
- Cottini Marzia
- Coupland Carol
- Covington Natalie V.
- Crawford Stephanie Y.
- Cruz Aparecido D.
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- Cuenda Ana
- Cui Huijuan
- Cui Qiang
- Cui Yanru
- Culver David C.
- Cunningham Catriona
- Cuypers Maarten
- Cyr Normand
- D\u27Angiulli Amedeo
- Dahms Tanya E.S.
- Dai Zhanwu
- Daigle France
- Dalgleish Raymond
- Dalrymple Brian P.
- Danchin Antoine
- Danielsen H\ue5vard E.
- Dao Myriam
- Darras S\ue9bastien
- Dauga Delphine
- Daulatabad Swapna V.
- Davidson Sean M.
- Day David A.
- de Keersmaecker Kim
- de Leeuw Frank-Erik
- de Maio Nicola
- Dean Lorraine T.
- Debrabant Birgit
- Degirmenci Volkan
- Del Tredici Andria L.
- Delahay Robin M.
- Delarocque Julien
- Demaison Luc
- Deng Zaian
- Denzel Martin S.
- Deschodt Mieke
- Devkota Hari P.
- Devkota Kiran
- Devos Lucie
- Devriendt Koenraad
- Dhar Aurup R.
- Dhariwal Raman
- Dhaval [NO FIRST NAME IN SCOPUS]
- Diao Jiajie
- Ding Jiandong
- Ding Ke-Feng
- Dings Ruud P.M.
- Diodato Daria
- Diouf Barthelemy
- Dixon Ray
- Dlamini S.V.
- Doan Lisa V.
- Dogan Yunus
- Domingues Helena S.
- Dong Kexian
- Dong X.C.
- Dong Zheng
- Donner Claudio F.
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- Dressick Walter
- Drevon Christian A.
- Dreyer Niklas
- Duan Huiling
- Ducho Christian
- Ducommun Bernard
- Dudley Kevin J.
- Duffey Maelle
- Dufies Maeva
- Duijf Pascal H.G.
- Dumaz Nicolas
- Dutt Avik
- Dwarakanath Bilikere S.
- Ebell Mark H.
- Echeverr\ueda Natalia
- Ecke Thorsten
- Eckweiler Denitsa
- Eerola Tuomas
- Effiong Andem
- Egea Luis G.
- Ehret Felix
- Eisenhardt Steffen
- Eixarch Elisenda
- Ekstrand Chelsea
- El-Adawy Hosny
- El-Esawi Mohamed A.
- El-Said Mohammed
- Elewa Yaser H.A.
- Elkum Naser
- Emmrich Julius V.
- Engel Michael S.
- Engel Nadja
- Epp Trevor
- Erickson Timothy B.
- Esfahlani Shabnam S.
- Eskelinen Eeva-Liisa
- Eskew Evan A.
- Esnakula Ashwini K.
- Eustace Alex J.
- Evangelou Evangelos
- Fairhead Michael
- Falk Sebastian
- Fallah Mazyar
- Falter-Wagner Christine M.
- Fan Dongsheng
- Fan Xiao
- Farber Debora B.
- Fardet Tanguy
- Farhoudi Ramin
- Faruk Mohammed
- Faville Marty J.
- Faye Martin
- Feghali Karine A.
- Feifei Shi
- Fejzo Marlena S.
- Feleke Berhanu E.
- Ferguson Trevor S.
- Fernandez-Fernandez Beatriz
- Fernandez-Triana Jose
- Festa Fernanda
- Feteira Antonio
- Feurer Thomas
- Feyerabend Frank
- Fierz Walter
- Filipp Fabian
- Flegel Willy A.
- Fleres Francesco
- Flood-Page Patrick
- Florio Tullio
- Foley Kieran G.
- Forano Evelyne
- Forsayeth John
- Foster Emma J.
- Foster Stephen
- Founou Luria L.
- Fox Simon A.
- Franks Steven J.
- Freitas Angela
- Frentiu Francesca D.
- Friebe Michael
- Frilander Mikko J.
- Fu Fan
- Fu Xinmiao
- Fujita Satoshi
- Furer Tzvi
- Furuta Saori
- Fuss Johannes
- Gabrielsen Mads
- Gadelkareem Rabea A.
- Gajda Maksymilian
- Galea Ian
- Galimov Evgeny
- Galluzzi Luca
- Gani Federica
- Ganpule Arvind P.
- Gao Jianzhao
- Gao Tian
- Gao Yibo
- Garc\ueda-Alix Antonio
- Garcia-Rivera Enid J.
- Garip Gulcan
- Gatchell Michael
- Gaullier Guillaume
- Gazdar Adi
- Gebremedhin [NO FIRST NAME IN SCOPUS]
- Gedye Kristene
- Gelfer Yael
- Gemmill Alison
- George Ronald B.
- Ghelardi Emilia
- Ghosh Sayantan
- Gianchecchi Elena
- Giganti Francesco
- Gill Martin R.
- Gilliham Matthew
- Giordano Maurizio
- Giunta Cecilia
- Gladue Douglas P.
- Gleason Joshua M.
- Gleeson Paul A.
- Gloyn Liz
- Gnasso Agostino
- Goarant Cyrille
- Gobet Ang\ue9lique
- Goggs Robert
- Gong Haipeng
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- Goodin Amie
- Goodyear Carl S.
- Gora Diop
- Gough Michael J.
- Gouil Quentin
- Govender Pragashnie
- Govinden Usha
- Goyal Ravinder
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- Gr\ufcneberg Patrick
- Grabowski Piotr
- Graham Emily B.
- Graham Kathryn E.
- Grande-P\ue9rez Ana
- Graves Patricia M.
- Greene Garrett
- Greenwald Noah F.
- Greidanus Harm
- Greiff Victor
- Grey James
- Grice Darren
- Gridneva Zoya
- Grimm Dominik G.
- Groen Ewout J.N.
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- Gruber Jens
- Grunau Christoph
- Grundle D.S.
- Grybos Malgorzata
- Guerra-Mora Jos\ue9 R.
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- Guignard L\ue9o
- Guisado J.L.
- Gumede Nicksy
- Gumulya Yosephine
- Guo Chengying
- Guo Xinyi
- Guo Yabin
- Gupta Himanshu
- Gurevich Vsevolod V.
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- Gusev Oleg
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- Hanson Jack
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- Hardingham Jennifer E.
- Harper Paul
- Harrison Pille
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- Heck Michelle
- Heers Marcel
- Heffler Enrico
- Heijne Marloes
- Heinemann Stephanie
- Heinrich Michael
- Helanter\ue4 Heikki
- Herbelet Sandrine
- Hew Khe F.
- Higginbottom Daniel B.
- Higuchi Yohei
- Hilaire Cynthia St.
- Hilton Rachel
- Hiroi Noboru
- Hobbs Emma
- Hodzic Enisa
- Hoenner Xavier
- Hogg William E.
- Hogrebe Alexander
- Hojsgaard Diego
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- Hone Andrew
- Hongoh Yuichi
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- Horbar Jeffrey
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- Hu Guoku
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- Huber Michael
- Hueso Luis E.
- Huirne Judith
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- Hunter Kylie E.
- Hurt Lisa
- Idborg Helena
- Ide Kazuki
- Ijzerman Adriaan P.
- Ikeo Kazuho
- Ikonomopoulou Maria P.
- Ingley Evan
- Iskander-Rizk Sophinese
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- Jahan Yasmin
- Jakeman Philip M.
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- Janga Sarath C.
- Janzen Thijs
- Jayaraman Jayakumar
- Jean-Quartier Claire
- Jeltsch Albert
- Jensen Arne
- Jeon Sang-Min
- Jesus Carlos
- Jeurissen Patrick
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- Jia Husen
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- Jia Yangyang
- Jian Gao
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- Jin Yi
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- Jurman Giuseppe
- Jutzeler Catherine
- Kabra Dhiraj
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- Kaiser Stefan
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- Karamanos Yannis
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- Karp Natasha A.
- Karsay Kathrin
- Kasian Olga
- Kauppila Joonas H.
- Kaur Harsheen
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- Kijanka Gregor S.
- Kim Hyeon J.
- Kim Yong-Min
- King Sarah R.B.
- Kinyanjui Timothy
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- Kish J.K.
- Kitazawa Takeshi
- Kiyani Musa
- Klein Reinhild
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- Kleppe Andreas
- Klump Hannes
- Kluz Tomasz
- Knox Paul
- Kobayashi Tatsuya
- Kobold Sebastian
- Koch Karl-Wilhelm
- Kohanbash Gary
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- Kohonen-Corish Maija R.J.
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- Kong Xiangpeng
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- Korpela Kalevi M.
- Kosanic Sasha
- Kostrikis Leondios G.
- Koutoukidis Dimitrios A.
- Kovesi Tom
- Kraiczy Peter
- Kramer Paul
- Kraschnewski Jennifer L.
- Kratz Harald
- Krause G\ufcnter
- Krebsbach Paul H.
- Kristensen S\uf8ren R.
- Kristiansson Erik
- Kueberuwa Gray
- Kugler Jan-Michael
- Kulkarni Ameya
- Kumar Addanki P.
- Kumar Dilip
- Kumar Gyanendra
- Kumar Narendra
- Kumar Nitin
- Kumari Prerna
- Kunimatsu Akira
- Kurdak Hatice
- Kurgan Lukasz
- Kurniawan Nicholas A.
- Kwon Young D.
- Labutin Dmitry
- Lachat Carl
- Lacy-Colson Jon
- Lagisz Malgorzata
- Lai Hei M.
- Laky Brenda
- Lalaouna David
- Lamberts Aniek
- Lammerding Jan
- Lange Matthias
- Lanza Giuseppe
- Larrosa Mar
- Laslett Andrew L.
- Latif Asam
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- Lauschke Volker M.
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- Leightley Daniel
- Leite Andreia
- Lercher Lukas
- Lewis James S.
- Li Bingling
- Li Genyuan
- Li Jian
- Li Jiansheng
- Li Jiuyong
- Li Maoteng
- Li Qingchun
- Li Tangliang
- Li Ying
- Li Yongzhe
- Li You
- Li Zhixiu
- Liang Dai
- Liang Huakang
- Liang Shide
- Liao Wei-Ting
- Liao Zheng-Yin
- Lidbury Brett A.
- Lieb Klaus
- Liehr Thomas
- Liew Alan W.C.
- Lim Chinten J.
- Lim Renly
- Lim Yau Y.
- Lima Luiz R.A.
- Lin Jessica
- Lin Li
- Lin Michael Z.
- Lindsey Merry L.
- Line Paul-Dag
- Ling Tong
- Linn Sabrina N.
- Litfin Thomas
- Liu Dengcai
- Liu Enwu
- Liu Fang
- Liu Fengbin
- Liu Haiyan
- Liu Hongde
- Liu Siqi
- Liu Xiaodong
- Liu Yu-Peng
- Liu Yuchen
- Liu Zhonghua
- Liusuo Wang
- Lizer J.
- Lloyd Vett K.
- Lo Te-Wen
- Lobreglio Giambattista
- Locci Emanuela
- Loft Nikolai D.
- Loidl Josef
- Lopez-Escamez Jose A.
- Lopez-Ruiz Francisco J.
- Lorenzen Johan
- Lorkowski Stefan
- Lovell Nigel H.
- Lowies Cher
- Lu Cheng
- Lu Hua
- Lu Jin-Jian
- Lu Qiang
- Lu Wei
- Lu Yao
- Lu Zhiyong
- Luengo Gustavo S.
- Lum Fok M.
- Lund Bjarte A.
- Lundh Lars-Gunnar
- Luo Hang
- Lussier Alexandre A.
- Luu Andreas M.
- Lygirou Vasiliki
- Lynch Iseult
- Lysy Philippe A.
- Lyu Ran
- Ma Chuang
- Ma Lan
- Ma Liping
- Ma Lisong
- Ma Ruiyan
- Ma Wujun
- Mabb Angela
- Machhi Jatin
- Mack Heather G.
- Mackey David A.
- Macleod Angus
- Macwan Isaac
- Madala Hanumantha R.
- Madani Nima
- Mahato Ajay K.
- Mahavadi Poornima
- Mahdavi S.R.
- Maher Pamela
- Maher Toby
- Mai Zhi-Ming
- Maibach Edward W.
- Maity Sankar N.
- Majeed Haroon
- Major Rupert W.
- Makowiecki Kalina
- Malgrange Brigitte
- Mali Samira
- Mallinson Daniel J.
- Mallis Panagiotis
- Mamoulakis Charalampos
- Mangoni Arduino A.
- Manke Thomas
- Manstead Antony S.R.
- Mantalaris Athanasios
- Mao Wenzhi
- Marchbank Kevin J.
- Margelyte Ruta
- Maria Caracausi
- Marinello Francesco
- Markonis Y.
- Marsal Jan
- Marschalek Rolf
- Marschall H. U.
- Marsili Luca
- Mart\uedn Carmen S.
- Martin Adam
- Martin Francis L.
- Martinez-Raga Jose
- Martinez-Salas Encarnacion
- Martinez-Sobrido Luis
- Martis Elvis
- Marvin-Dowle Katie
- Marzocchi Ugo
- Mason Leanda D.
- Mather Diane E.
- Mathieu Daniel
- Matsui Yoichi
- Mavoa Suzanne
- Maza Elie
- McCrum Christopher
- McCutcheon James E.
- McGarrigle Christine A.
- McKay Gareth J.
- McMillan Brian
- McMillan Nigel
- McWilliams Lorna
- Meads Catherine
- Medina Loreta
- Megersa Moa
- Mendes Caetano S.M.
- Menichetti Julia
- Mercieca-Bebber Rebecca
- Meresh Edwin
- Merideth Ben
- Merino-Plaza Maria J.
- Merlaen Britt
- Merrick B. Alex
- Meseko Clement
- Messina Rossella
- Metzger Dennis W.
- Meule Adrian
- Meunier Frederic A.
- Michaelis Martin
- Micheau Olivier
- Middelveen Marianne
- Miele Adriana E.
- Mier Pablo
- Mihara Hisaaki
- Miller Jack J.
- Min Rogier
- Minde David-Paul M.
- Minges Alexander
- Mintz Eric M.
- Miotla Pawel
- Mishra Anand K.
- Mishra Eleanor
- Mishra Virendra R.
- Mitchell Kate M.
- Mizukami Takuo
- Moal Iain
- Moalic Yann
- Mohapatra D.P.
- Mohebbi Alireza
- Molari Massimiliano
- Molleman Lucas
- Mondal Saiful R.
- Montagutelli Xavier
- Monteiro Antonia
- Montes Matthieu
- Moore Matthew D.
- Moores Carly
- Moran John V.
- Morcillo Esteban
- Morozov Sergey Y.
- Morrice Nicola
- Mort Matthew
- Moskalensky Alexander E.
- Moss W.N.
- Mota Jorge
- Moultos Othonas A.
- Moyer Robert
- Mozaheb Zahra
- Muhammad Junaid
- Mukherjee Maheswari
- Murai Noriyuki
- Murphy Denis J.
- Murphy Susan K.
- Murray Shauna A.
- Musinguzi Conrad
- Muth Thilo
- Muyaya Ley
- Naganawa Shinji
- Nagler Katja
- Nakayama Kazuhiko
- Nammi Srinivas
- Nandakumar Kutty S.
- Nandhakumar Amar
- Nanou Afroditi
- Naqash Amreen
- Narayan Edward
- Nasios Grigorios
- Natoli Roman M.
- Navaratnarajah [NO FIRST NAME IN SCOPUS]
- Navarin Nicol\uf2
- Negera Edessa
- Neumann Philipp-Alexander
- Ng Grace
- Ng Sheryl H.X.
- Nguyen Frederique
- Nguyen Joe T.
- Nguyen Thi T.H.
- Ni Duan
- Nicol Christine
- Nicoletti Rosario
- Nida [NO FIRST NAME IN SCOPUS]
- Nie Jiyun
- Nie Yingjiu
- Niehof Monika
- Niemeyer Frank
- Nilsen Erlend B.
- Nilsson Henrik
- Nixon Brett
- Nobile Clarissa J.
- Nolan Fiona
- Nolet Philippe
- Nord\ue9n Rickard
- Nordberg Ana
- Norris Adam D.
- Notcovich Shirli
- Nowicki Jessica P.
- Nwaiwu Ogueri
- O\u27Mahony Margaret
- O\u27Toole Ronan
- Obeidat Monther
- Ogami Koichi
- Oh Deog-Hwan
- Ohgami Robert S.
- Ohlsson Sophie
- Ohst Barnabas
- Ohtomo Toshihiko
- Olatunbosun Oluremi
- Oldenmenger Wendy H.
- Ollivier Quinn R.
- Olofsson Per
- Olova Nelly
- Olszewski Pawel
- Olumayede Emmanuel
- Onzima Robert
- Orme Mark W.
- Ortiz Alberto
- Osses Dani\uebl F.
- Oster Henrik
- Ostrikov Kostya
- Otto Siegmar
- Ou Jianhong
- Outeiro Tiago F.
- Ouyang Songying
- Owais Mohammed
- Pace-Asciak Pia
- Paganoni Sabrina
- Page Andrew
- Pallebage-Gamarallage Menuka
- Palm Christoph
- Palma Jose-Alberto
- Pan Chih-Long
- Pan Zihang
- Panthee Suresh
- Panwar Ajay
- Paradies Yin
- Parchi Piero
- Park Caroline
- Park Charny
- Park Dong I.
- Park Seyoung
- Parsons Jerod R.
- Parsons Michael H.
- Parsons Nick
- Pascal Pigny
- Paterson Russell
- Patil Chandrashekhar D.
- Patterson Chris
- Paul Elisabeth
- Pearce Simon P.
- Pearson James A.
- Peckham Michelle
- Pedemonte Nicoletta
- Pedro Sansoa A.
- Peifer Mark
- Pelkonen Tuula
- Pelleri Maria C.
- Pellizzon Michael A.
- Penagos-Tabaree Felipe
- Peng Xiangda
- Peng Yousong
- Perco Paul
- Pereira Joana L.
- Peres Marco A.
- Perry Samuel R.
- Peter Jessica
- Peterson Brent M.
- Petrelli M.
- Pezzuolo Andrea
- Pheko Mpho
- Pianosi Paolo T.
- Pichugin Alexander
- Pinto Carlos J.C.
- Pinto Ines M.
- Pinto Karina A.
- Pinzi Valentina
- Piotrowski Marcin
- Piovesan Allison
- Plantinga Arnoud
- Plevris John N.
- Pluess Michael
- Podolsky Illya M.
- Pollesello Piero
- Polz Martin
- Ponti Giovanna
- Popoola Segun I.
- Porcelli Piero
- Portilla Maribel
- Portillo M.C.
- Pourret Olivier
- Pozdnyakov Ilya
- Prajapati Anilkumar S.
- Pranata Raymond
- Prescott Julie
- Pridans Clare
- Prieto Daniel
- Prince Martin
- Pritchard Antonia L.
- Psaroulaki Anna
- Pujala Ravi K.
- Pulia Michael
- Pulido-Arjona Leonardo
- Pullan Wayne
- Pusch Stefan
- Qi Dongchen
- Qi Peng-Fei
- Qi Xingshun
- Qian Siyu
- Qin Lei
- Quinn Gwendolyn P.
- Quinn Terence J.
- Rafe Ali
- Rafiq Muhammad
- Raghava Gajendra P.S.
- Rahimi Farid
- Rahman Proton
- Rahman Shaifur
- Rai Nayanjot K.
- Raikou Vaia D.
- Raman Ayush
- Ramula Satu
- Ranft Andreas
- Raote Ishier
- Rappsilber Juri
- Rassaf Tienush
- Raucher-Ch\ue9n\ue9 [NO FIRST NAME IN SCOPUS]
- Rawski Rafal
- Ray Asit
- Raza Ali
- Razak Lubna A.
- Rebl Henrike
- Reddan Tristan
- Refai Osama
- Refardt Julie
- Regan Tim
- Rehfeldt Florian
- Reiling Jan H.
- Remacle Claire
- Reschke Cristina R.
- Rezaei Mohsen
- Rhodes Johanna
- Ricciardi Walter
- Richa Tambi
- Richardson Mark F.
- Riddick Eric W.
- Riess Olaf
- Ritter Uwe
- Riva Giuseppe
- Roach Neil W.
- Roberts David D.
- Roberts Nicola J.
- Robinson K.R.
- Robles Guillermo
- Rodrigues Tiago
- Rodriguez Cesar
- Roislien Jo
- Roobol Monique J.
- Ross Kehinde
- Ross Stephanie A.
- Rossoni Luca
- Rotge Jean-Yves
- Rouet Romain
- Rovas Alexandros
- Rowe Alexandra
- Rowe Anna D.
- Rudolf Kevin
- Ruepp Andreas
- Rusch Peter
- Rust Petra
- S\uf6relius Karl
- Saad Sonia
- Sabnis Sandeep C.
- Sack George H.
- Sacks Frank M.
- Sadoine Margaux L.
- Safaei Soroush
- Saggar Manish
- Saito Yu
- Salama Mohamed F.
- Saleh Sherif
- Sallmon Hannes
- Sampson Christopher
- Santos Manuela
- Saudemont Aurore
- Sava Gianni
- Schmidt Axel
- Schmutz Axel
- Schneeberger Pierre H.H.
- Schrading Simone
- Schramm Alexander
- Schreiber Martin
- Schuele Birgitt
- Schuler Sidney
- Schulte Leon N.
- Schuon Robert A.
- Schurr Roey
- Schwotzer Daniela
- Schymkowitz Joost
- Sczyrba Alexander
- Searles Stephen
- Sebastian Agata
- Seib Kate L.
- Selinski Jennifer
- Seltmann Stefanie
- Senghore Thomas
- Seow Esmond
- Sepanski Robert
- Sergeant Kjell
- Sha Feng
- Shabalin Ivan G.
- Shahid Shaouli
- Shalchyan Vahid
- Shalev Nir
- Shang Jin-Long
- Sharma Neeraj
- Sharma Saurab
- Sheehan Barry
- Shen Jun
- Shi Chunhu
- Shi Han-Ping
- Shimada Tomohiro
- Shin Jeon-Soo
- Shirvalkar Prasad
- Shiryayev Oleg
- Shohayeb Belal
- Shortt Colette
- Siebers Robert
- Sillanp\ue4\ue4 Elina
- Silveyra Patricia
- Singer Josef
- Singh Jugpreet
- Singh Mandeep
- Singh Manisha
- Skinner Debra
- Small Ian
- Smeets Paul A.M.
- Smith Simon S.
- Smith Taylor
- Smout Michael J.
- So Po-Wah
- Soares Ant\uf3nio
- Solano Francisco
- Solomon-Moore Emma
- Sommerlad Andrew
- Sonenshine Daniel E.
- Song Chunjiao
- Song Haijun
- Song Jiangning
- Song Lijuan
- Soraggi Samuele
- Sorzano Carlos O.
- Southall Tony
- Speakman John R.
- Spearman Paul
- Srinivasan Mandyam V.
- Srivastava Kshitij
- Srivastava Rupesh K.
- Stabile Laura P.
- Staege Martin S.
- Stanley Ryan
- Stasiak A.
- Steadman Kathryn J.
- Steckhan Nico
- Stein Nils
- Stella Alessandro
- Stephens Andrew W.
- Stevanovic Dejan
- Stewart Christopher J.
- Stewart Douglas I.
- Stine Keith
- Storlazzi Curt
- Stoynova Nataliya V.
- Strehlow Jan
- Strobl Frederic
- Strzalka Wojciech
- Suarez Oscar M.
- Subhash Santhilal
- Subissi Lorenzo
- Subramaniapillai Mehala
- Sukocheva Olga
- Sultana Taranum
- Sumant Anirudha V.
- Summers Mathew J.
- Sun Gang
- Sun Jim
- Sun Xianbao
- Sundar Raghav
- Supriyanto Irwan
- Surve Chinmay R.
- Suzuki Tomo
- Swali Ritu
- Sydes Matthew
- Syme Caitlin
- Szabo Attila
- Szymanski Wiktor
- Tacon Paul
- Taherzadeh Ghazaleh
- Tahir Nur D.M.
- Tai Chan N.P.
- Takeuchi Hisashi
- Tamaian Radu
- Tan Aik-Choon
- Tan Cher M.
- Tan Ene-Choo
- Tan Kok H.
- Tanadini-Lang S.
- Tanaka Kozo
- Tang Fei
- Tang Haixu
- Tang Jun
- Tang Young
- Tanino Y.
- Tantawy Marwa
- Tao Wanyin
- Targett-Adams Paul
- Tayebi Mourad
- Tayyem Reema
- Tebbe Christoph C.
- Telfer Evelyn E.
- Tellechea Juan I.
- Tempel Wolfram
- Tennakoon Sumudu
- Teodorczyk-Injeyan Julita A.
- Terrier Olivier
- Teseo Serafino
- Testa Jean
- Testoni Ines
- Theron G.
- Thijs Gert
- Thomas Lisa-Marie
- Thorne Sally
- Thrift Amanda G.
- Tian Chang F.
- Tian Yu-Shi
- Tian Zhiqi
- Tiffon Celine
- Tingting Qian
- Tinnefeld Philip
- Tjahjono Daryono H.
- Toelzer Christine
- Tofani Marco
- Tolle Fabrice
- Tomov Nikola
- Tong Xin
- Torga Gonzalo
- Toth Ervin
- Tovar Miguel
- Tr\uf6der Simon E.
- Tran Linh
- Tressoldi Patrizio
- Tripathi Sushil
- Tsapas Apostolos
- Tsirigotis Konstantinos
- Tuladhar Anil M.
- Turak Ayse
- Tuttle Lisa M.
- Tuttle Neil
- Tzotzos George
- Uchendu Florence
- Udo Edet E.
- Uhle Florian
- Ukubuiwe Azubuike C.
- Ung Carolina O.L.
- Utsumi Toshiaki
- Uversky Vladimir N.
- Vaidyanathan Subramanian
- Vaillant Michel
- Valenti Anna
- Valgepea Kaspar
- Valsesia Armand
- van de Mortel Thea
- van den Bos Wouter
- van Dessel Pieter
- van Meerten Tom
- van Nieuwerburgh Filip
- van Raaij Mark J.
- van Ruitenbeek Jan
- Vandenbroucke Roosmarijn E.
- Vanneste Sven
- Vatanparast Hamid
- Vavvas Demetrios G.
- Veiga Feliciano H.
- Vendrell Marc
- Verheijen Geert P.
- Verloh Niklas
- Verlot Pierre
- Vesk Peter A.
- Veys Ralf
- Vickers Paul
- Vickstrom Casey
- Victor Victor M.
- Vidal Arnau
- Villemur Richard
- Villet Martin H.
- Vindin Howard
- Vitriol Veronica
- Viveiros Miguel
- Vohl Marie-Claude
- Voolstra Christian R.
- Vorholt Julia A.
- Voskarides Konstantinos
- Voutchkova Denitza D.
- Vuillemin Anne
- Wakelin Steven
- Waldron Levi
- Walker Mirella
- Walsh Laurence J.
- Wang Amanda Y.
- Wang Fang
- Wang Fuan
- Wang Horng-Dar
- Wang Jinhui
- Wang Jiucun
- Wang Jun
- Wang Qing
- Wang Teng
- Wang Xiaomin
- Wang Yun
- Wang Zhenxing
- Watanabe Yoichi
- Watari Ricky
- Waugh Jason
- Webb S.A.
- Webster Rebecca
- Webster Ruth
- Wei Junnian
- Wei Pan
- Weigert Andreas
- Weinstock Christof
- Welter Danielle
- Wen Jet-Chau
- Werner Gijsbert D.A.
- Werten Sebastiaan
- Westermair Anna L.
- Wham Carol
- White Ethan P.
- Wibowo David
- Widera Darius
- Wiener Jan
- Wilharm Gottfried
- Wilkinson Simon
- Williams Brendan A.
- Williams Richard
- Willmann Raffaella
- Wilson Alex
- Wilson Coralie
- Wingenbach Tanja S.H.
- Winslade Matthew
- Wirth Brunhilde
- Wojan Timothy R.
- Woldesemayat Adugna A.
- Wolff Mathieu
- Wong Alvin
- Wong Bryan M.
- Workman Alan D.
- Wu Dalei
- Wu Tzu-Wei
- Wu Yi-Rui
- Wuerbel Hanno
- Wyart [NO FIRST NAME IN SCOPUS]
- Xavier Rose M.
- Xia Wenfeng
- Xiang Tingxiu
- Xiao Han
- Xiao Shumin
- Xiao Xiangshu
- Xie Li-Xin
- Xiong Peng
- Xu Beisi
- Xu Dong
- Xu Haotian
- Xu J.W.
- Xu Jialin
- Xu Jianping
- Xu Juan
- Xu Jun
- Xu Shicai
- Xu Shilin
- Xu Taosheng
- Xu Ziyue
- Xue Bin
- Xue Yu
- Yadollahpour Ali
- Yalcin Suayib
- Yamato Masayuki
- Yan Hong
- Yang Chongjun
- Yang Dongdong
- Yang En-Cheng
- Yang Hui
- Yang Long
- Yang Mingjun
- Yang Shiqi
- Yang Sunny Y.
- Yang Wei
- Yang Yongliang
- Yankilevich Patricio
- Yao Ruifeng
- Yao Wen
- Yassine Abdul-Amir
- Ye Yuzhen
- Ye Zhi-Qiang
- Yeung Andy W.K.
- Yin Cong-Cong
- Yin Qinan
- Yli-Kauhaluoma Jari
- Yoneyama Hiroshi
- Yoon Jihoon G.
- You Yuyi
- Yousefzadeh Abbas
- Yu Chenglong
- Yu Ying
- Yu Yongbo
- Yuan Christina M.
- Yuan Guo-Cheng
- Yuh Chiou-Hwa
- Zabetakis Ioannis
- Zaccolo Manuela
- Zaitsu Masayoshi
- Zare Asma
- Zaritsky Arno
- Zaucha Jan
- Zeineb Zian
- Zeng Chen
- Zeng Erliang
- Zeng Zhen
- Zevnik Branko
- Zhan Jian
- Zhan Xiao-Yong
- Zhang Chengrong
- Zhang Chi
- Zhang Chongxing
- Zhang Gong
- Zhang Haowen
- Zhang Jilei
- Zhang Junpeng
- Zhang Kai
- Zhang Li
- Zhang Linxing
- Zhang Rongqiang
- Zhang Tongchuan
- Zhang Tuo
- Zhang Wei
- Zhang Weijia
- Zhang Xianglilan
- Zhang Xiaolei
- Zhang Yao
- Zhang Yi
- Zhang Yingkai
- Zhang Yusen
- Zhang Zhe
- Zhang Zhiyong
- Zhang Zhong-Yin
- Zhang Zhongheng
- Zhao Guoyan
- Zhao Haochen
- Zhao Jing
- Zhao Xin
- Zhao Yuan
- Zheng Shan
- Zhou Bailing
- Zhou Jianyu
- Zhou Kai
- Zhou Min
- Zhou Xiaofan
- Zhou Xiaoyan
- Zhou Yaoqi
- Zhu Dongjie
- Zhu Shu
- Zhu Zhenxing
- Ziegler Andreas
- Zinke Katharina
- Zuberbier Torsten
- Zuckerman Hannah
- Publication venue
- Publication date
- 01/01/2019
- Field of study
Document recommendation systems for locating relevant literature have mostly relied on methods developed a decade ago. This is largely due to the lack of a large offline gold-standard benchmark of relevant documents that cover a variety of research fields such that newly developed literature search techniques can be compared, improved and translated into practice. To overcome this bottleneck, we have established the RElevant LIterature SearcH consortium consisting of more than 1500 scientists from 84 countries, who have collectively annotated the relevance of over 180 000 PubMed-listed articles with regard to their respective seed (input) article/s. The majority of annotations were contributed by highly experienced, original authors of the seed articles. The collected data cover 76% of all unique PubMed Medical Subject Headings descriptors. No systematic biases were observed across different experience levels, research fields or time spent on annotations. More importantly, annotations of the same document pairs contributed by different scientists were highly concordant. We further show that the three representative baseline methods used to generate recommended articles for evaluation (Okapi Best Matching 25, Term Frequency-Inverse Document Frequency and PubMed Related Articles) had similar overall performances. Additionally, we found that these methods each tend to produce distinct collections of recommended articles, suggesting that a hybrid method may be required to completely capture all relevant articles. The established database server located at https://relishdb.ict.griffith.edu.au is freely available for the downloading of annotation data and the blind testing of new methods. We expect that this benchmark will be useful for stimulating the development of new powerful techniques for title and title/abstract-based search engines for relevant articles in biomedical research.Peer reviewe
Understanding the multi-dimensional mental well-being in late life: evidence from the perspective of the oldest old population
- Author
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 23/02/2019
- Field of study
The promotion, maintenance, and improvement of well-being among the oldest old population is becoming a great public health concern. This study aimed to explore the experiences of individuals aged 80 plus regarding their mental well-being (MWB) and its contributing factors in four European countries. A qualitative approach was followed, with twenty-three focus groups. One hundred and seventeen respondents were recruited from senior community centers, adult day care centers, and nursing homes. Data was assessed using qualitative content analysis. Participants\u2019 perspectives on MWB were collated along four dimensions: functional, social, personal and environmental. Staying healthy and maintaining independence, having close relationships with others, and insightful experiences with friends positively contributed to MWB. Additionally, engagement in fruitful or inspiring activities contributed to enhance personal development, which, in turn, had beneficial effects on MWB. Having a positive outlook was also found to be associated with MWB. Results reinforce the dynamic and multidimensional nature state of MWB, as well as highlighting the significance of psychosocial factors. Developing and implementing policy actions including a focus on the social and physical environment as well as strengthening personal capabilities and self-esteem, can foster MWB among the oldest old population
Parque Nacional de Caba\uf1eros entorno abi\uf3tico y bot\ue1nica de los ecosistemas acu\ue1ticos
- Author
- Publication venue
- Madrid : Grupo de Investigaci\uf3n del Agua
- Publication date
- Field of study
Parque Nacional de Caba\uf1eros entorno abi\uf3tico y bot\ue1nica de los ecosistemas acu\ue1ticos
- Author
- Publication venue
- Madrid : Grupo de Investigaci\uf3n del Agua
- Publication date
- Field of study
Reduced Cancer Incidence in Huntington's Disease: Analysis in the Registry Study
- Author
- \u160a\u161inkov\ue1 Pavla
- \u160enk\ue1rov\ue1 Zuzana
- \uc5man Jaana
- Aaserud Olaf
- Abbruzzese Giovanni
- Agarwal Veena
- Akhtar Shahbana
- Alarc\uf3n Moreau Mar\ueda Dolores
- Albanese Alberto
- Allain Philippe
- Almagro Carmen Ant\ufanez
- Almeida Manuel
- Alonso-Frech Fernando
- Alusi Sundus
- Anderson Mary
- Andersson Christian
- Andrade Carlos
- Andrew Alyson
- Andrews Thomasin
- Andrich J\ufcrgen
- Angeles Maria
- Aniola Jacek
- Anjum Uruj
- Annic Agn\ue8s
- Antczak Jakub
- Arbelo Jos\ue9 Mat\uedas
- Arkuszewski Michal
- Armstrong Richard
- Arntsen Vibeke
- Arques Penelope Navas
- Arran Natalie
- Artiga Mar\ueda Jos\ue9 Sainz
- Azulay Jean-Philippe
- B\ue1rcenas Antonio Herranz
- B\uf6ringer Regina
- Baake Verena
- Babiloni Blandine
- Bachmeier Michael
- Bachoud-L\ue9vi Anne-Catherine
- Badei Farideh
- Bailey Wendy
- Banaszkiewicz Krzysztof
- Bandmann Oliver
- Barbera Miquel Aguilar
- Barker Roger A.
- Barral Ver\uf3nica Ma\uf1anes
- Barrero Francisco
- Barth Katrin
- Barth\ue9l\ue9my Recka
- Bas Jordi
- Bechtel Natalie
- Beckmann Heike
- Bek Judith
- Bellonet Marcellin
- Benaich Sandra
- Benoit Alexandra
- Bentivoglio Anna Rita
- Berglund Maria
- Berglund Peter
- Bergmann Ulrike
- Berrisoul Hassan
- Bertini Elisabetta
- Bethwaite Pamela
- Betz Sabrina
- Beuth Markus
- Bioux Sandrine
- Biunno Ida
- Bj\uf6rnsson Elisabeth
- Bj\uf8rgo Kathrine
- Bj\uf8rnevoll Inga
- Blaszczyk Magdalena
- Bliaux Evangeline
- Blin St\ue9phanie
- Blinkenberg Ellen 8kland
- Blondeau Leily
- Bo\u107wi\u144ska Dorota
- Boczarska-Jedynak Magdalena
- Boelmans Kai
- Bohlen Stefan
- Boiss\ue9 Marie-Fran\ue7oise
- Bojakowska-Jaremek Kamila
- Bojarsky Jaime Kulisevsky
- Bonelli Raphael M.
- Bonneau Dominique
- Boogaerts Andrea
- Borge\uf8d Nancy
- Bos Reineke
- Bosca Maria
- Bosredon Cecile
- Bost Marie
- Boudali Lotfi
- Bove Francesco
- Bradbury Alyson
- Braunwarth Eva-Maria
- Brice Alexis
- Brockie Peter
- Bronzova Juliana
- Brugada Francisco Castera
- Brugger Florian
- Bruno Stefania
- Bryl Anna
- Buchanan Lindsay
- Buck Andrea
- Buongiorno Mar\ueda Teresa
- Buratti Lisa
- Burguera Juan Andres
- Burgunder Jean-Marc
- Burn John
- Burrows Liz
- Busquets N\ufaria
- Busse Monica
- Butcher Cynthia
- Cabaret Maryline
- Calado Ana
- Calandra-Buonaura Giovanna
- Caldentey Juan Garc\ueda
- Callaghan Jenny
- Calopa Matilde
- Calvas Fabienne
- Calzado Noemi
- Campolongo Antonia
- Cannella Milena
- Capellari Sabina
- Capetian Philipp
- Capodarca Selene
- Cardoso Helena
- Carette Anne-Sophie
- Carri\ue8re Nicolas
- Carrillo F\ue1tima
- Carruesco Gemma Tome
- Casado Roc\uedo Villagr\ue1n
- Cass Ginette
- Castagliuolo Simona
- Castaldo Anna
- Catalli Claudio
- Catena Judit L\uf3pez
- Chabot Christelle
- Charles Perrine
- Charpentier S\ue9bastien
- Cheriet Samia
- Chu Carol
- Chu Elvina
- Ciach-Wysocka Ewelina
- Ciesielska Anna
- Classen Serge Jaum\ue1
- Clayton Carole
- Clenaghan Catherine
- Coarelli Giulia
- Codella Valentina
- Coebergh Jan
- Coelho Miguel
- Coleman Caroline
- Come Adrien
- Connemann Julia
- Constant Eric
- Constantinescu Radu
- Cormio Claudia
- Corrales Koldo Berganzo
- Cortegana Eva Mar\ueda Pacheco
- Cortelli Pietro
- Costa Andreia
- Costa Cristina
- Coulthard Elizabeth
- Courtin Fran\ue7oise
- Couttier Julien
- Craufurd David
- Craven Janet
- Crooks Jenny
- Cubillo Patricia Trigo
- Cubo Esther
- Curtis Adrienne
- D\ucdaz-Zorita Juan Pablo Tartari
- Da Silva Wildson Vieira
- Das Purkayastha Debasish
- Davidson Lynn
- Davies Rhys
- Davison Jill
- De Bobadilla Ramon Fernandez
- De Bruycker Christelle
- De Gregorio Francesca
- De La Cerda Santa Mar\ueda Andr\ue9s
- De Langavant Laurent Cleret
- De Michele Giuseppe
- De Molina Roc\uedo Malo
- De Nicola Annunziata
- De Souza Keylock Jenny
- De Tommaso Marina
- De Weert A. Marit
- De Y\ue9benes Justo Garc\ueda
- Debilly B\ue9reng\ue8re
- Debruxelles Sabrina
- Dec Malgorzata
- Decorte Eric
- Dedich\ue1 Nadia Rodr\uedguez
- Defebvre Luc
- Deith Catherine
- Dekker Meike
- Del Mar Fenollar Mar\ueda
- Del Valle Loarte Mar\ueda
- Delabaere Hel\ue8ne
- Delaigue Christine
- Delfini Marie
- Delliaux Marie
- Delval Arnaud
- Demonet Jean-Fran\ue7ois
- Depelchin Aliz\ue9
- Destee Alain
- Dewulf-Pasz Nelly
- DI Bella Daniela
- DI Donato Stefano
- DI Giacopo Raffaella
- DI Maio Luigi
- DI Maria Emilio
- DI Pietro Anna Gerrtiz
- DI Poggio Monica Bandettini
- DI Renzo Martina
- DI\ue9guez Esther
- DIas Margarida
- DIercks Gabriele
- DIfruscolo Olimpia
- DIpple Heather
- Doherty Karen
- Dondaine Thibaut
- Donovan John O
- Dose Matthias
- Dougherty Andrew
- Downie Lorna
- Dramstad Elisabeth
- Dressler DIrk
- Duch\ue9 Charlotte
- Dugauquier Florence
- Duits Annelien
- Dujardin Kathy
- Dumas Eve M.
- Dunnett Stephen
- Dupuis Michel
- Durif Franck
- Durr Alexandra
- Duru C\ue9cile
- Dziadkiewicz Artur
- Ecker Daniel
- Eddy Charlotte
- Edwards Maureen
- Edwards Rachel
- Eklund Pia
- Ekwall Camilla
- Elifani Francesca
- Ellrichmann Gisa
- Esposito Federica
- Esteban Juan Carlos Gomez
- Eusebio Alexandre
- Evans Carole
- Ewenczyk Claire
- Fairtlough Helen
- Fannemel Madeleine
- Farewell Daniel
- Fasano Alfonso
- Fasquel V\ue9ronique
- Fernandez Cristina Melgar
- Ferraldeschi Michela
- Ferrandes Giovanna
- Ferreira Joaquim J
- Ferrer Pilar Quil\ue9z
- Figuerola Bego\uf1a Jeweinat
- Fillingham Kay
- Finisterra Ana Maria
- Fisher Kate
- Flament M\ue9lanie
- Fletcher Amy
- Fluchere Fr\ue9d\ue9rique
- Fortuna Lorenza
- Foster Jillian
- Foustanos Isabella
- Foy Kevin
- Frades Bel\ue9n
- Francis Flverly
- Francisque H\ue9l\ue8ne
- Franco Giovanni
- Frech Fernando Alonso
- Fredlund Gunnel
- Freire-Patino Dawn
- Frich Jan C.
- Frontali Marina
- Frost Julie
- Fullam Ruth
- Fuller Kathleen
- G\uf6ller Marie-Lousie
- G\uf6pfert Nicole
- G\uf8rvell Per F.
- Gago Miguel
- Gallassi Roberto
- Gallentree Deena
- Ganos Christos
- Garc\ueda Ana
- Garc\ueda Roc\uedo Garc\ueda-Ramos
- Garcia-Amigot Fermin
- Garde M\uf3nica Bascu\uf1ana
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- Gayde-Stephan Sabine
- Geitner Carolin
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- Gellera Cinzia
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- Genoves Camille
- Gerrans Emily
- Ghelli Elena
- Gil Acera
- Gill Paul
- Gillardin Anne-Fran\ue7oise
- Gilling Mette
- Ginestroni Andrea
- Girard Carole
- Giuliano Joe
- Godefroy Olivier
- Goerendt Ines
- Gogol Anna
- Gohier B\ue9n\ue9dicte
- Goizet Cyril
- Golding Charlotte
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- Gonz\ue1lez Laura Vargas
- Gonz\ue1lez Sonia
- Good Jean-Marc
- Goodman Anna
- Gorzkowska Agnieszka
- Gorzolla Heike
- Goudie David
- Gowers Lesley
- Grabska Natalia
- Grosjean H\ue9l\ue8ne
- Gu\ue9rid Marie-Anne
- Guedes Leonor Correia
- Guia Dolors Badenes
- Guidubaldi Arianna
- Guimar\ue3es Joana
- Guisasola Luis Men\ue9ndez
- Gunner Kerry
- Guyant-Mar\ue9chal Lucie
- Guzman Natalie Valle
- H\uf6lzner Eva
- H\uf8sterey-Ugander Ulrika
- Haider Salman
- Haig-Brown DIane
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- Hamer Stephanie
- Hametner Eva-Maria
- Handley Olivia J.
- Hannequin DIdier
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- Harrower Timothy
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- Herrera Carmen Dur\ue1n
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- Hoffmann Rainer
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- Hughes Max
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- Idiago Jes\ufas Miguel Ruiz
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- Illarioshkin Sergey
- Illmann Torsten
- Ireland Jane
- Irvine Sarah
- J\ue4\ue4skalainen Outi
- J\ufalio Filipa
- Jachinska Katarzyna
- Jack Roisin
- Jacobsen Oda
- Jacopini Gioia
- Jameau Laetitia
- Jamieson Stuart
- Jamrozik Zygmunt
- Janik Piotr
- Janu\ue1rio Cristina
- Jasi\u144ska-Myga Barbara
- Jauffret C\ue9line
- Johns Nicola
- Johnson Liz
- Jones Lesley
- Jones Mary
- Jones Una
- Jourdain S\ue9verine
- Jung Hans H.
- Justo Damian
- K\ue4rpp\ue4 Mikko
- Kaczmarczyk Aleksandra
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- Kaiserova Michaela
- Kajula Outi
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- Kaminski Barbara
- Kammel Gerit
- Kampstra Anne
- Kapfhammer Hans-Peter
- Kassar Abdulrahman
- Kavalier Fred
- Kazoka Mbombe
- Kesse Andrea
- Keys Liane
- Khalil Hanan
- Kipps Christopher
- Klebe Stephan
- Klemp\ued\u159 Ji\u159\ued
- Klimberg Aneta
- Klodowska-Duda Gabriela
- Klooster Jesper
- Knight Caroline
- Kohl Zacharias
- Koivisto Susana Pro
- Komati Suresh
- Koppers Kerstin
- Koppitz Michael
- Kosinski Christoph Michael
- Kozay Christina
- Kramer Bianca
- Kraus Alison
- Kraus Peter
- Krawczyk Malgorzata
- Kremer Berry
- Krishnamoorthy Ashok
- Krysa Wioletta
- Krystkowiak Pierre
- Kubowicz Ewelina
- Kwiecinski Hubert
- L\ue9onard Marie-Claude
- L\uf3pez Rosa Guerrero
- L\uf6hle Matthias
- L\ufcsebrink Antje
- Ladurner Gunther
- Lafoucri\ue8re Danielle
- Lagha-Boukbiza Ouhaid
- Lahiri Nayana
- Laing Hana
- Lamanna Claudia
- Lambeck Johann
- Landwehrmeyer Bernhard
- Lange Herwig
- Larcher Barbara
- Large Sandra
- Larsen Ida Unmack
- Lashwood Alison
- Laur\ue1 Matilde
- Laver Fiona
- Leenders Nico
- Legendre Perrine
- Lemaire Marie-H\ue9l\ue8ne
- Lemoine Laurie
- Lemos Mar\ueda Dolores Romero
- Lesne Fabien
- Levey Jamie
- Lewerenz Jan
- Lewis Monica
- Leypold Christine
- Lezius Franziska
- Ligon-Auer Maria
- Lilek Sabine
- Lilek Stefan
- Lindquist Suzanne
- Linnsand Petra
- Loiseau Sylvie
- Lolk Annette
- Longato Nadine
- Longinus Bernhard
- Longthorpe Mandy
- Lopera Monica Rodriguez
- Loria Giovanna
- Loutfi Ghada
- Lovo Francesca
- Lozano Pablo S\ue1nchez
- Lucena Carolina Mendez
- Lundsgaard Marianne
- M\ue4chtel Miriam
- M\uf8ller Anette Torvin
- M\ufchlau Mark
- M\ufchlb\ue4ck Alzbeta
- M\ufcller Christoph
- M\ufcller Nicole
- M\ufcnchau Alexander
- M\ufcnkel Kristina
- M\ufctze Lisanne
- Maass Antonia
- MacKinnon Lesley
- Madsen Louise Hasselstr\uf8m
- Magnet Markus
- Mahlknecht Philipp
- Maiwald Robert
- Majeed Tahir
- Majerov\ue1 Veronika
- Malec-Litwinowicz Michalina
- Malt\ueate David
- Mandich Paola
- Mandich Paola
- Manouvrier Sylvie
- Mantaux B\ue9atrice
- Manzanares Salvadora
- Marcel Christophe
- Marchese Roberta
- Marcinkowski Jerzy
- Mariotti Caterina
- Mariscal Natividad
- Markova Ivana
- Marquard Ralf
- Mart\uedn Idaira
- Mart\uednez Noelia Rodr\uedguez
- Mart\uednez-Descals Asunci\uf3n
- Martikainen Kirsti
- Martin Veronica Puertas
- Martinez-Horta Saul
- Martinez-Jaurrieta Maria Dolores
- Martino Tiziana
- Mason Sarah
- Massano Jo\ue3o
- Massarelli Marco
- Mata Maite Paredes
- Matheson Kirsty
- Mazzante Irene
- McDonnell Sharon
- McEntagart Meriel
- McFadyen Paula
- McGill Marie
- McKenzie Sue
- McLean Tim
- McNulty Paul
- Mechi Claudia
- Meier Simone
- Meireles Joana
- Mendes Tiago
- Merino Beatriz Tijero
- Mestre Tiago
- Middleton Julia
- Miedzybrodzka Zosia
- Mihaylova Violeta
- Milani Paolo
- Milkereit Eva
- Minet C\ue9cile
- Minschke Rebecca
- Minster Sara
- Mir Pablo
- Modoni Anna
- Mohammed Zeid
- Moilanen Jukka
- Monin Marie-Lorraine
- Monteiro Ana
- Monza Daniela
- Morales Blas
- Moreno Jos\ue9 Luis L\uf3pez-Send\uf3n
- Moreno Jose Manuel Garc\ueda
- Moreno Patrocinio Garcia
- Morgado Graca
- Morgado Joana
- Morgan Karen
- Mu\uf1oz Esteban
- Mu\uf1oz Juan Mar\uedn
- Mundler Laura
- Murphy Helen
- Musacchio Thomas
- Musgrave Hannah
- Mustonen Aki
- Mutez Eug\ue9nie
- N\uf6th Kerstin
- Nanetti Lorenzo
- Necuiniate Renata
- Neleborn-Lingefj\ue4rd Liselotte
- Nemeth Andrea H
- Nepper Solveig
- Nevitt Louise
- Nielsen J\uf8rgen
- Niess Anke
- Noad Rupert
- Novak Marianne
- Nowak Malgorzata
- Nowak Marielle
- Nyberg Clara
- O'Donovan Kirsty
- O'Keefe Deidre
- O'Neill Mari
- Oehmen Martin
- Olivier Audrey
- Ollokainen Mari
- Olofsson Carina
- Oosterloo Mayke
- Opala Grzegorz
- Orth Michael
- Ossig Christiana
- Otti Daniela
- Oughton Emma
- Owen Michael
- P\ue4iv\ue4rinta Markku
- P\ue5lhagen Sven
- Padieu Helene
- Paganini Marco
- Pagonabarraga Javier
- Painold Annamaria
- Palanca Paloma Millan
- Palmer Amy
- Panzeri Marta
- Pardo Sonia Arribas
- Paridi Dominga
- Pariente J\ue9r\ue9mie
- Parkinson Andrew
- Partington-Jones Lucy
- Pastor Barbara Vives
- Pate Louise
- Patel Aakta
- Paterski Laurent
- Patton Michael
- Paucar Martin
- Paus Karin
- Pe\uf1a Jos\ue9 Chac\uf3n
- Peacy Caroline
- Pearson Pauline
- Peinemann Alexander
- Peippo Maarit
- Peluso Silvio
- Peppa Nadia
- Perea Fuensanta Noguera
- Perez Jesus Perez
- Peria\uf1ez Juan Manuel
- Peter Mireille
- Petersen Jens A.
- Peterson Maria
- Petracca Martina
- Petrollini Martina
- Phillipps Cl\ue9lie
- Phillips Michelle
- Piacentini Silvia
- Piano Carla
- Piccininni Chiara
- Pierre Mich\ue8le
- Pilcher Richard
- Pinter Bernadette
- Playe Alicia
- Plomhause Lucie
- Poda Roberto
- Poewe Werner
- Polo Cecilia Gil
- Porteous Mary
- Pouliquen Doroth\ue9e
- Powell Kingsley
- Pr\ufc f Harald
- Pradella Silvia
- Price Kathleen
- Prieto Marta Para
- Priller Josef
- Probst Daniela
- Prouzet Julie
- Prundean Adriana
- Pueyo Angel Mart\uednez
- Quaranta Davide
- Quarrell Oliver
- R\uf8ren Niini
- R\uf8sby Oddveig
- Rae Daniela
- Rakowicz Maryla
- Raman Ashok
- Ramesh Raviram
- Ramirez In\ue9s Legarda
- Ramos-Arroyo Maria Antonia
- Raseta Rolland
- Redondo Luis
- Redondo Mar\ueda Teresa C\ue1ceres
- Reetz Kathrin
- Regeur Lisbeth
- Reilmann Ralf
- Reisinger Karin
- Reiter Eva-Magdalena
- Retterst\uf8l Lars
- Riba\uef Pascale
- Ribacoba Ren\ue9
- Ribas Guillermo Garc\ueda
- Ribbat Michael
- Ribosa Roser
- Richter Przemyslaw
- Rickards Hugh
- Rijntjes Michel
- Rinaldi Carlo
- Rindal Beate
- Ristori Giovanni
- Ritchie Stuart
- Robert Misericordia Floriach
- Robertson Dene
- Robertson Nicola
- Robowski Piotr
- Roca Alessandro
- Roca Elvira
- Rogers Dawn
- Rohm Stefanie
- Rola Rafal
- Rolland Sandrine
- Romano Silvia
- Romero Irene
- Romero Sandra Gutierrez
- Romoli Anna Maria
- Roos Raymund A. C.
- Rose Sarah
- Rosser Anne
- Rosser Elisabeth
- Roth Jan
- Rothery Jean
- Roussel Martine
- Rowett Liz
- Roze Emmanuel
- Ru\uedz Pedro Jos\ue9 Garc\ueda
- Ruddy Deborah
- Rudolf Gabrielle
- Rudzi\u144ska Monika
- Rumpf Silke
- Russo Cinzia Valeria
- Ryglewicz Danuta
- S\ue1nchez Vicenta
- S\ue1nchez Violeta S\ue1nchez
- S\ufcssmuth Sigurd
- Sablonni\ue8re Bernard
- Saft Carsten
- Salvador Carlos
- Salvatore Elena
- Samara Husam
- Sando Sigrid Botne
- Santacruz Pilar
- Santala Maire
- Santhouse Alastair
- Sass Christian
- Savage Lois
- Scaglione Cesa
- Sch\uf6ggl Helmut
- Sch\ufcler B\ue9atrice
- Sch\ufcpbach Michael
- Scheibl Monika
- Schepers Sigrun
- Scherer-Gagou Clarisse
- Schiefer Johannes
- Schlangen Christiane
- Schmalfeld Jenny
- Schmidt Simone
- Schneider Ariane
- Schoonderbeek Anne
- Schrader Christoph
- Schwenk Daniela
- Sciruicchio Vittorio
- Sebasti\ue1n Ana Rojo
- Seliverstov Yury
- Semedo Cristina
- Sempolowicz Justyna
- Seppi Klaus
- Serpino Claudia
- Sevilla Maria Ascension Zea
- Sienkiewicz-Jarosz Halina
- Sieradzan Kasia
- Sikiric Alma
- Silva Mark
- Simonelli Maria
- Simonin Cl\ue9mence
- Simpson Sheila A
- Simpson Steve
- Sinadinosa Daniela
- Singh Baldev
- Sipponen Marjett
- Sitek Emilia
- Siuda Gill
- Slawek Jaroslaw
- Smalley Sarah
- Snowden Julie
- Sol\ueds Pilar
- Soleti Francesco
- Solito Marcella
- Soliveri Paola
- Sollom Andrea
- Soltan Witold
- Soltysiak Beverley
- Sorbi Sandro
- Sorrentino Pierpaolo
- Spadaro Maria
- Spagnolo Francesca
- Spampinato Umberto
- Sprenger Fabienne
- Spruth Eike
- Squitieri Ferdinando
- St 9pniak Iwona
- St\ue4dtler Michael
- St\uf8rseth Hanna Haugan
- Staffen Wolfgang
- Stamm Christiane
- Stattin Eva-Lena
- Stebler Yanik
- Steinmetz Gis\ue9le
- Stenwak Agata
- Stockholm Jette
- Stokke Bodil
- Stompel Daniel
- Stopford Cheryl
- Storch Alexander
- Stubbe Lars
- Sulek Anna
- Summers Fiona
- Sundblom Jimmy
- Svenningsson Per
- Swain Rachel
- Szczudlik Andrzej
- Szczygiel Elzbieta
- Szinwelski Michal
- Tabrizi Sarah
- Tacik Pawel
- Tard C\ue9line
- Taroni Franco
- Tataru Alina
- Taylor Anne-Marie
- Taylor Cat
- Taylor Rachel
- Tchikviladz\ue9 Maya
- Thibault-Tanchou St\ue9phanie
- Thiel Silvia
- Thomas Gareth
- Thompson Jennifer
- Thomson Aileen
- Tidswell Katherine
- Timewell Erika
- Timings Leanne
- Tir M\ue9lissa
- Tomasello Chiara
- Tonner Alison
- Torlizzi Flavia
- Torres Mar\ueda Martirio Antequera
- Toscano Jean
- Townhill Jenny
- Tranchant Christine
- Trautmann Sonja
- Trender-Gerhard Iris
- Tucci Tecla
- Tuuha Katri
- Tyvoll Hilde
- Udaeta Beatriz
- Uhrova Tereza
- Ulla Miguel
- Ullah Jasmin
- Ure Alexandra
- Valadas Anabela
- Valentine Ruth
- Van De Wyngaerde Fran\ue7oise
- Van Den Bogaard Simon J. A.
- Van Hout Monique S. E.
- Van Oostrom Joost
- Van Paemel Dominique
- Van Reijen Dimphna
- Van Vugt Jeroen P. P.
- Van Walsem Marleen
- Vandenberghe Wim
- Vangsted-Hansen Christina
- Vaughan Vivien
- Ventura Marta Fat\ue1s
- Verellen-Dumoulin Christine
- Verhoeven Marloes
- Vernon Nathan
- Verny Christophe
- Verstappen Carla
- Verstraelen Nicola
- Vezza Maurizio
- Vidal Tiphaine
- Viladrich C\ue8lia Mareca
- Vilaplana Carmen Peir\uf3
- Villa Riballo Antonio
- Villa Carolina
- Villanueva Clara
- Villanueva Marina \uc1vila
- Vingerhoets Francois
- Vinther-Jensen Tua
- Vivancos Laura
- Vogel Melanie
- Vuillaume Isabelle
- W\uf3jcik Magdalena
- Waber Mirella
- Wagner Caroline
- Wahlstr\uf6m Jan
- Wallden Tina
- Walleczek Anna Maria
- Wannepain Sandrine
- Warner Thomas
- Wasielewska Anna
- Weber Nathalia
- Weekes Rebecca
- Wehus Ragnhild
- Weindl Adolf
- Wenning Gregor
- Wermuth Lene
- Werner Cornelius J.
- Westman Laila
- Westmoreland Leann
- Weydt Patrick
- Whaite Anna
- Wi\u15bniewski Bartlomiej
- Wider Christian
- Wikstr\uf6m Birgitta
- Wild Edward
- Wild Sue
- Williams Josh
- Winkelmann Juliane
- Winkler J\ufcrgen
- Witjes-An\ue9 Marie-Noelle
- Witkowski Grzegorz
- Wolz Annett
- Wolz Martin
- Wood Josh
- Wright Abigail
- Wright Jan
- Yardumian Pam
- Yates Shona
- Youssov Katia
- Yudina Elizaveta
- Zaremba Jacek
- Zaugg Sabine Weber
- Zdzienicka Elzbieta
- Ziegler Cornelia
- Zielonka Daniel
- Zielonka Eugeniusz
- Zimmermann Marie-Agathe
- Zinzi Paola
- Ziora-Jakutowicz Karolina
- Zittel Simone
- Zucker Birgit
- Publication venue
- 'IOS Press'
- Publication date
- 01/01/2018
- Field of study
Background: People with Huntington's disease (HD) have been observed to have lower rates of cancers. Objective: To investigate the relationship between age of onset of HD, CAG repeat length, and cancer diagnosis. Methods: Data were obtained from the European Huntington's disease network REGISTRY study for 6540 subjects. Population cancer incidence was ascertained from the GLOBOCAN database to obtain standardised incidence ratios of cancers in the REGISTRY subjects. Results: 173/6528 HD REGISTRY subjects had had a cancer diagnosis. The age-standardised incidence rate of all cancers in the REGISTRY HD population was 0.26 (CI 0.22-0.30). Individual cancers showed a lower age-standardised incidence rate compared with the control population with prostate and colorectal cancers showing the lowest rates. There was no effect of CAG length on the likelihood of cancer, but a cancer diagnosis within the last year was associated with a greatly increased rate of HD onset (Hazard Ratio 18.94, p < 0.001). Conclusions: Cancer is less common than expected in the HD population, confirming previous reports. However, this does not appear to be related to CAG length in HTT. A recent diagnosis of cancer increases the risk of HD onset at any age, likely due to increased investigation following a cancer diagnosis
Management of coronary disease in patients with advanced kidney disease
- Author
- Abdallah M Abdallah Abel E Moreyra, Abhay A Laddu, Abhishek Dubey, Abhishek Goyal, Abigail Knighton, Adedayo Adeboye, Agne Juceviciene, Agne Urboniene, Agnieszka Szramowska, Ahmed Abdel-Latif, Ahmed Ayoub, Ahmed Elghamaz, Ahmed Kamal, Ahmed Talaat, Ajay Sharma, Ajit Singh Narula, Akshay Bagai, Akvile Smigelskaite, Alain Raymond, Alain Rheault, Alaine Melanie Loehr, Albert Varga, Aldo P Maggioni, Alec Moorman, Alejandro Chevaile Ramos, Alejandro Gisbert, Aleksandra Fratczak, Aleksandras Laucevicius, Alexander M Chernyavskiy, Alexander Sergeevich Borisov, Alexandra Craft, Alexandra Hunter, Alexandre Ciappina Hueb, Alexandre Schaan de Quadros, Alice Manica Muller, Aline Peixoto Deiro, Allegra Stone, Almudena Castro, Amar Uxa, Amaryllis Van Craenenbroeck, Ambuj Roy, Amit Kakkar, Amy Flowers, Amy Iskandrian, Ana D Djordjevic-Dikic, Ana Gomes Almeida, Ana Rita Francisco, Ana S Mladenovic, Ana Santana, Anandaroop Lahiri, Anastasia M Kuzmina-Krutetskaya, Anastasia Vamvakidou, Andras Vertes, Andre Gabriel, Andrea Bartykowszki, Andrea Lorimer, Andrea Pascual, Andreia Coelho, Andreia Rocha, Andr\ue9s Garc\ueda-Rinc\uf3n, Andrew Starovoytov, Andrzej \u141abyk, Anelise Kawakami, Angela Hoye, Angelo Nobre, Anjali Acharya, Anjali Anand, Anjana Rishmawi, Ann Banfield, Ann Luyten, Anna Cichocka-Radwan, Anna Fojt, Anna Plachcinska, Anna Teresinska, Anne Marie Webb, Anne Heath, Anoop Mathew, Antonia Vega, Antonio Carvalho, Antonio Colombo, Antonio Fiarresga, Anu Tharini, Anupama Rao, Aquiles Valdespino-Estrada, Ariel Diaz, Arif Asif, Arnold H Seto, Arturo S Campos-Santaolalla, Asim N Cheema, Asker Ahmed, Atul Mathur, Audrey W Leong, Axel \uc5kerblom, Axelle Fuentes, Aynun Naher, Badhma Valaiyapathi, Balaji Srinivasan, Baljeet Kaur, Balram Bhargava, Bandula Guruge, Barbara Wicklund, Bartosz Czarniak, Bebek Singh, Bego\uf1a Igual, Bela Merkely, Benoy N Shah, Bernard de Bruyne, Beth Abramson, Beth Stefanchik, Bethany Harvey, Bharati Shivalkar, Bilal Malik, Binoy Mannekkattukudy Kurian, Bougrida Hammouche, Branko D Beleslin, Bruce Ferguson, Bruce McManus, Bruna Maria Ascoli, Bryn Smith, Byron J Allen, C Michael Gibson, C Noel Bairey Merz, Calin Pop, Carl-\uc9ric Gagn\ue9, Carly Ohmart, Carol M Kartje, Caroline Alsweiler, Caroline Rodgers, Caroline Spindler, Carolyn J Gruber, Catherine Albert, Catherine Bone, Catherine Lemay, Cezary Kepka, Chandini Suvarna, Chantale Mercure, Charlene Wiyarand, Chetan Patel, Chiara Attanasio, Chi-Ming Chow, Ching Min Er, Ching-Ching Ong, Cholenahally Nanjappa Manjunath, Chris Buller, Christel Vassaliere, Christiaan Vrints, Christian Witzke, Christie Ballantyne, Christina Bj\uf6rklund, Christine Roraff, Christophe Laure, Christophe Thuaire, Christopher Chan, Christopher Fordyce, Christopher Kinsey, Chunli Xia, Cidney Schultz, Claes Held, Claudia Cort\ue9s, Claudia Escobar, Cl\ue1udia Freixo, Clemens T Kadalie, Corine Thobois, Courtney Page, Cristina Bare, Dalisa Espinosa, Dan Gao, Dana Rizk, Daniela Puzhevsky, Data Analyst, David M Charytan, David O Williams, David Booth, David Charytan, David Cohen, David DeMets, David Foo, David Goldfarb, David Schlichting, David Sisson, David Taggart, David Waters, David Wheeler, David Williams, Davis Vo, Dawid Teodorczyk, Dawn D Shelstad, Dean Kereiakes, Deborah Yip, Deepa Ramaswamy, Deirdre Mattina, Deirdre Murphy, Dengke Jiang, Derek Cyr, Diana Cukali, Diane Camara, Dimitrios Stournaras, Dipti Patel, Dongze Li, Donna Exley, Doreen Reimann, Doron Schwartz, Duarte Cacela, Dwayne S G Conway, Eapen Punnoose, Edgar L Tay, Edgar Karanjah, Eduardo Gomes Lima, Eduardo Hernandez-Rangel, Edward D Nicol, Edyta Kaczmarska, Elena Refoyo Salicio, Eli Feen, Elih\ufa Dur\ue1n-Cort\ue9s, Elisabeth M Janzen, Elise van Dongen, Elissa Restelli Piloto, Elizabeta Srbinovska Kostovska, Elizabeth Capasso-Gulve, Elizaveta V Zbyshevskaya, Ellie Fridell, Ellis W Lader, Elvira Gosmanova, Emilie Tachot, Emma Howard, Emmanuel Sorbets, Encarnaci\uf3n Alonso-\uc1lvarez, Eric Daugas, Erick Alex\ue1nderson Rosas, Estelle Montpetit, Eugene Passamani, Evgeny Shutov, Ewa Szczerba, Ewelina Wojtala, Expedito Eust\ue1quio Ribeiro Silva, Fabio Fimiani, Fadi Hage, Fahim Haider Jafary, Fang Feng, Fatima Ranjbaran, Fausto J Pinto, Fernando Caeiro, Fernando Nolasco, Filipa Silva, Filippo Ottani, Firas Al Solaiman, Fl\ue1via Egydio, Florina Chereches, Francesca De Micco, Francesca Bianchini, Francesca Pietrucci, Francesco Orso, Francesco Pisano, Francisca Patuleia Figueiras, Fran\ue7ois Madore, Frank Harrell, Frank Rockhold, Frans Van de Werf, Franziska Guenther, Fred Mohr, G Karthikeyan, Gabriel Galeote, Gabriel Grossmann, Gabriel Steg, Gabriela Guzman, Gabriele Gabrielli, Gang Chen, Gautam Sharma, Gaylin Petty, Gelmina Mikolaitiene, Gennie Yee, Gerard Patrick Devlin, Gerard Esposito, Gergely \uc1goston, Gervasio Lamas, Gia Cobb, Gian Piero Perna, Gianpiero Leone, Girish Mishra, Gonzalo Barge-Caballero, Grace M Young, Graciela Scaro, Graham Wong, Gregg Pressman, Gregor Simonis, Gudrun Steinmaurer, Guilherme Portugal, Guilhermina Cantinho Lopes, Guillermo Garcia-Garcia, Guoqin Wang, Gurpreet S Wander, Gurpreet Gulati, Haibo Zhang, Halina Marciniak, Hao Dai, Haojian Dong, Harold Franch, Harvey White, Hatem Elabd, Hayley Pomeroy, Heather Golden, Heidi Wilson, Helene Abergel, Hemalata Siddaram, Hemant Shakhar Mahapatra, Henry C Stokes, Hermine Osseni, Herwig Schuchlenz, Hicham Skali, Holly Mattix-Kramer, Hong Cheng, Hossam Mahrous, Hristo Pejkov, Hugo Marques, Hui Zhong, Hussien El Fishawy, Ian Webb, Iftikhar Kullo, Igor O Grazhdankin, Ikraam Hassan, Ileana L Pina, Ilona Tamasauskiene, In\ueas Zimbarra Cabrita, Ines Rodrigues, Inga Soveri, Irena Peovska Mitevska, Irene Marthe Lang, Irina Subbotina, Irma Kalibataite-Rutkauskiene, Isabelle Roy, Ishita Tejani, Ivan A Naryshkin, Ivana Jankovic, Iwona Niedzwiecka, Jacek Kusmierek, Jackie Chow, Jaekyeong Heo, Jakub Maksym, James E Davies, James J Jang, James Hirsch, James Tatoulis, Jan Henzel, Janaina Oliveira, Janani Rangaswami, Jane Eckstein, Janitha Raj, Jaqueline Pozzibon, Jaroslaw Drozdz, Jason Loh Kwok Kong, Jason T Call, Jason Linefsky, Javier J Garcia, Jay Meisner, Jayne Scales, Jean Michel Juliard, Jean Diodati, Jean-Michel Juliard, Jeanne Russo, Jeannette J M Schoep, Jeff Leimberger, Jeffrey C Milliken, Jeffrey Anderson, Jeffrey Kanters, Jeffrey Lorin, Jeffrey Moses, Jelena J Stepanovic, Jelena Celutkiene, Jelena Stojkovic, Jenne M Jose, Jennifer L Stanford, Jennifer Hogan, Jennifer Horst, Jennifer Isaacs, Jennifer Thomson, Jennifer Tomfohr, Jennifer White, Jerry Yee, Jessica Berg, Jesus Peteiro, Jes\ufas Peteiro, Jia Li, Jiamin Liu, Jianxin Zhang, Jill Marcus, Jim Blankenship, Jing Dong, Jiyan Chen, Jo Evans, Joaqu\uedn V Pe\uf1afiel, Joe Sabik, Johann Christopher, John B Kostis, John Joseph Graham, John Doan, John Jose, John Kotter, John Lehman, John Middleton, John Pownall, Jonathan M Gleadle, Jonathan S Chavez-I\uf1iguez, Jonathan Byrne, Jonathan Himmelfarb, Jonathan Lebowitz, Jonean Thorsen, Jorge Carrillo Calvillo, Jorge Escobedo, Jos\ue9 A Ortega-Ram\uedrez, Jos\ue9 J Cuenca-Castillo, Jose L Diez, Jos\ue9 Luis Narro Villanueva, Jos\ue9 Luiz da Costa Vieira, Jos\ue9 M Flores-Palacios, Jose Fragata, Jose Lopes, Jose Lopez-Sendon, Jos\ue9 Lopez-Sendon, Jose Rueda, Joseph B Selvanayagam, Joseph Sacco, Joshua P Loh, Joy Burkhardt, Juan Manuel L\uf3pez Quijano, Juan Gaztanaga, Judit Sebo, Judith Wright, Juergen Stumpf, Julia de Aveiro Morata, Julio C\ue9sar Figal, Julio Hernandez Jaras, Junqing Yang, Jyotsna Garg, K Manjula Rani, K Preethi, Kaatje Goetschalckx, Karen Calfas, Karen Petrosyan, Karen Servilla, Karen Swan, Karin Ploetze, Karolina Kryczka, Karolina Wojtczak-Soska, Karolina Wojtera, Karthik Ramasamy, Katarzyna \u141uczak, Katarzyna Malinowska, Katharina Knaut, Katherine Martin, Kathleen Claes, Kathryn Mason, Ken Mahaffey, Kenneth Gin, Kerry Lee, Kerstin Bonin, Kerstin Mikes, Kevin R Bainey, Kevin T Harley, Kevin Marzo, Kevin McMahon, Khaled Abdul-Nour, Khaled Alfakih, Khaled Dajani, Khrystyna Kushniriuk, Kian-Keong Poh, Kim Holland, Kimberly E Halverson, Kinnari Murphy, Kiran Reddy, Kirsten J Quiles, Kirsty Abercrombie, Klaus Matschke, Konrad Szymczyk, Koo Hui Chan, Kreton Mavromatis, Krishnakumar Hongalgi, Kristian Thygesen, Kristin M Salmi, Kristin Newby, Kristine Arges, Kristine Teoh, Krzysztof Drzymalski, Lalathaksha Kumbar, Laszlone Matics, LaTonya J Hickson, Laura Keinaite, Laura Sarti, Laura True, Lawrence M Phillips, Lawrence Friedman, Leandro C Maranan, Leda Lotaif, Lekshmi Dharmarajan, Leo A Bockeria, Leonardo Pizzol Caetano, Leonardo Bridi, Leonid L Bershtein, Li Hai Yan, Li Li, Lidia Sousa, Lihong Xu, Lihua Zhang, Lili Zhang, Lilian Mazza Barbosa, Liljana Tozija, Linda Arcand, Lino Patricio, Liping Zhang, Lisa Hatch, Lixin Jiang, Liz Low, Loay Salman, Lorena Lopez, Lori Pritchard, Luis Bernanrdes, Luis Guzman, Lynette L Teo, M Sowjanya Reddy, Maarten Simoons, Maayan Konigstein, Mafalda Selas, Magdalena Madero, Magdalena Miller, Magdalena Misztal-Teodorczyk, Magdy Abdelhamid, Magid Fahim, Mahevamma Mylarappa, Majo X Joseph, Malgorzata Frach, Manjula Rani, Marcello Galvani, Marcin Demkow, Marcin Szkopiak, Marco De Fabritis, Marco Magnoni, Marco Marini, Marco Sicuro, Marek Roik, Maria A Alfonso, Maria Antonieta Pereira de Moraes, Mar\ueda Dolores Mart\uednez-Ru\uedz, Maria Eugenia Canziani, Maria Eugenia Martin, Maria In\ueas Caetano, Maria P Corral, Maria P\ue9rez Garc\ueda, Maria Andreasson, Maria Posada, Marianna D A Dracoulakis, Mariano Rubio, Marija T Petrovic, Marina Vieira, Mario J Garcia, Mario D'arezzo, Maris Orgera, Marius Miglinas, Mark Garand, Mark Peterson, Mark Xavier, Marlowe Mosley, Marta Capinha, Marta Swiderek, Martha Meyer, Martina Ceseri, Martinia Tricoli, Mary Wiilliams, Mary Ann Champagne, Mary Streif, Massoud Leesar, Matei Claudia, Mateusz Solecki, Mat\uedas Nicol\ue1s Mungo, Matthew Shinseki, Matthew Weir, Maura Carina N\ue9dio, Max-Paul Winter, Mayil S Krishnam, Meenakshi Mishra, Mei Hwang, Melemadathil Srilatha, Melissa LeFevre, Mengistu Simegn, Michael A Gibson, Michael B Rubens, Michael D Shapiro, Michael Chobanian, Michael Davidson, Michael Farkouh, Michael Mack, Michal Wlodarczyk, Michel G Khouri, Michelle Crowder, Michelle Ratliff, Miguel Borges Santos, Miguel Nobre Menezes, Miguel Perez Fontan, Miguel Barrero, Mihaly Tapolyai, Mikhail T Torosoff, Milan R Dobric, Milind Avdhoot Gadkari, Min Tun Kyaw, Miri Revivo, Mitchel B Lustre, Mohamed Adel, Mohamed Hassan, Mohammad El-Hajjar, Mohammed Hussain, Mohammed Saleem, Mois\ue9s Blanco-Calvo, Mois\ue9s Jim\ue9nez-Santos, Monika Laukyte, Muhamed Saric, Myrthes Emy Takiuti, Nadia Asif, Nagaraja Moorthy, Naima L Ogletree, Nana O Katamadze, Nandita Nataraj, Naomi Uchida, Nasrul Ismail, Natalia S Oliveira, Natalia de Carvalho Maffei, Nathalie Brosens, Naved Aslam, Naveed Akhtar, Neamat Mowafy, Neeraj Pandit, Neeraj Parakh, Neesh Pannu, Neill Duncan, Nevena Garcevic, Ngaire Meadows, Nicholas Danchin, Nicole Deming, Nikola N Boskovic, Nikolaos Karogiannis, Ning Zhang, Nirmal Kumar, Niruta Sharma, Nitika Chadha, Nitish Naik, Noelle M Durfee, Nora M Cosgrove, Norbert Urbanski, Norma Hogg, Olga Walesiak, Olga Zdo\u144czyk, Olga Zhdanova, Olivia Anaya, Olugbenga Bello, Omar Almousalli, Omar Thompson, Orit Kliuk, Oscar M\ue9ndiz, 3scar Prada-Delgado, Oz Shapira, Pablo Raffaele, Page Salanger, Pal Maurovich-Horvat, Pallav Garg, Paloma Moraga, Pam Singh, Pamela Ouyang, Pamela Woodard, Paola Emanuela Poggio Smanio, Paola Smanio, Paolo Calabro, Patricia K Nguyen, Patricia Alarie, Patricia Carrilho, Patricia Endsley, Patricia Pellikka, Patrycja Lebioda, Paul Der Mesropian, Paul Hauptman, Paula Garc\ueda-Gonz\ue1lez, Paula Wilson, Paulo Cury Rezende, Paulo Novis Rocha, Pedro Canas Silva, Pedro Farto E Abreu, Pedro P\uedccaro de Oliveira, Pedro Carvalho, Pedro Modas, Pedro Rio, Peiyu He, Peter A McCullough, Peter H Stone, Peter Douglass, Peter Sizeland, Peter Voros, Philippe Gabriel Steg, Philippe Genereux, Philippe G\ue9n\ue9reux, Philippe Menasche, Philippe Rheault, Piero Tassinario, Pierre Gervais, Pilar Calvillo, Ping Chai, Piotr Jakubowski, Piotr Pruszczyk, Poay-Huan Loh, Pouneh Samadi, Prakash Deedwania, Pranav M Patel, Praneeth Polamuri, Pratiksha Sharma, Preeti Kamath, Prince Thomas, Priyadarshani Arambam, Puneet Sodhi, Pushpa Naik, Qi Zhong, Qian Zhao, Qianqian Yuan, Qiulan Xie, Rachel Murphy, Radmila Lyubarova, Radmilar Lyubarova, Raewyn Fisher, Rafael Diaz, Rafael Maldonado, Rafael Selgas, Raffaele Bugiardini, Rafia Chaudhry, Raisa Kavalakkat, Rajalekshmi Vs, Rajesh Gopalan Nair, Rajiv Narang, Rakesh Yadav, Ramiro Carvalho, Ramon de Jes\ufas-P\ue9rez, Ran Leng, Ranjan Kachru, Raquel Sanchez, Raven R Dwyer, Raven Lee, Ray Wyman, Raymond C Wong, Reinette Hampson, Renato Abdala Karam Kalil, Renato D Lopes, Renato George Eick, Renato Lopes, Reshma Ravindran, Reto Andreas Gamma, Ricardo Costa, Richa Bhatt, Richard H J Trimlett, Risha Patel, Rita Coram, Robert K Riezebos, Robert M Donnino, Robert Guyton, Robert Harrington, Robert Malecki, Roberto Ren\ue9 Favaloro, Robyn Elliott, Rodolfo G S D Lima, Rohit Tandon, Rolf Doerr, Roma Tewari, Ron Wald, Rongrong Hu, Rory Collins, Roxana Mehran, Roxy Senior, Rub\ue9n Bale\uf3n-Espinosa, Ruben Ramos, Rui Ferreira, Ruth Kirby, Ruth P\ue9rez-Fern\ue1ndez, S Ramakrishnan, S K Dwivedi, Sadath Lubna, Sadiq Ahmed, Sajeev Chakanalil Govindan, Salamah Alfalahi, Salvador Cruz-Flores, Salvatore P Costa, Sampoornima Setty, Samuel Nwosu, Sandeep Mahajan, Sandeep Seth, Sandeep Singh, Sander R Niehe, Sandy Carr, Sanja Simic Ogrizovic, Sanja Ogrizovic, Sanjeev Gulati, Sanjeev Sharma, Sara Fernandez, Sarah Williams, Sarju Ralhan, Sasko Kedev, Satinder Singh, Satish Sankaranarayanan, Satvic Cholenahally Manjunath, Sau Lee, Schawana Thaxton, Sean M O'Brien, Sebastian Sobczak, Seema Nour, Sergey A Sayganov, S\ue9rgio Bravo Baptista, Sergio Draibe, Seth Sokol, Sharad Chandra, Shari Mackedanz, Shaun Goodman, Shayan Shirazian, Sheetal Rupesh Karwa, Sheri Ussery, Sheromani Bajaj, Shirin Heydari, Shiv Kumar Choudhary, Shivali Patel, Shruti Pandey, Shuyang Zhang, Siddharth Gadage, Sik-Yin V Tan, S\uedlvia Zottis Poletti, Silvia Valbuena, Simone Savaris, Solomon Yakubov, Songlin Zhu, Sonika Gupta, Sorin Brener, Sothinathan Gurunathan, Soundarya Nayak, Sowjanya Reddy, Stanley E Cobos, Stefan Weikl, Stephanie M Lane, Stephanie Ferket, Stephanie Mavromichalis, Stephen Fremes, Steven A Fein, Steven P Sedlis, Steven Giovannone, Steven Weitz, Subhash Banerjee, Sudhanva S Hegde, Suellen Hosino, Sulagna Mookherjee, Suman Singh, Sumith Abeygunasekara, Sundeep Mishra, Sunil Kumar Verma, Suresh Kumar, Suryaprakash Narayanappa, Susan K Milbrandt, Susana Silva, Susanna Stevens, Suvarna Kolhe, Suzana Tavares, Suzanne Welsh, T A Kishore, Tamara Colai\ue1covo Soares, Tapan Umesh Pillay, Tarek Rashid, Tarun K Mittal, Tauane Bello Duarte, T\ue9odora Dutoiu, Teresa Delgadillo, Terrance Chua, Terrance Welch, Theodoros Kofidis, Thierry Lefevre, Tiago Silva, Timea Boros, Titus Lau, Tiziana Formisano, Tomasz Ciurus, Tomasz Tarchalski, Tracy Tan, Umesh Lingaraj, V K Bahl, V S Narain, Valentina Pellu, Valentine Lobo, Valerie Robesyn, Vandana Yadav, Veerabhadra Gupta, Verghese Mathew, Vicente Miro, Victoria Gumerova, Victoria Hernandez, Vijay Kher, Vijay Kumar, Vikas Makkar, Vikranth Reddy, Viktoria Bulkley, Vinoi George David, Virendra Misra, Virginia Fern\ue1ndez-Figares, Vladimir Ryasniansky, Vojislav L Giga, Wael A Almahmeed, Wan Xian Chan, Wanda C Marfori, Wanda Parker, Wayne Pennachi, Wei Ling Lau, Weibing Xing, Weijing Bian, Wendy L Stewart, Wendy Drewes, Whady Hueb, William Weintraub, Winnie C Sia, Xacobe Flores-R\uedos, Xiang Ma, Xiangqiong Gu, Xiaomei Li, Xiaoyi Xu, Xin Fu, Xuemei Li, Xutong Wang, Yanek P\ue9pin-Dubois, Yaron Arbel, Yechen Han, Yiming Lit, Ying Tung Sia, Ying Wang, Yining Yang, Yitong Ma, Yolayfi Peralta, Yves Smets, Yvonne Taul, Zalina Kudzoeva, Zeljko Z Markovic, Zhangsuo Liu, Zhenyu Liu, Zhiming Ye, Zixiang Yu, Zoltan Davidovits, Zvezdana Petronijevic
- Alexander K.P.
- Ali Z.A.
- Bangalore S.
- Berger J.S.
- Bockeria O.
- Boden W.E.
- Briguori C.
- Broderick S.
- Chaitman B.R.
- Chertow G.M.
- Fleg J.L.
- Herzog C.A.
- Hochman J.S.
- Huang Z.
- Kaul U.
- Kretov E.I.
- Mark D.B.
- Maron D.J.
- Mathew R.O.
- Mazurek T.
- Newman J.D.
- O'Brien S.M.
- Pracon R.
- Reynolds H.R.
- Sidhu M.S.
- Spertus J.A.
- Stone G.W.
- Publication venue
- 'Massachusetts Medical Society'
- Publication date
- 01/01/2020
- Field of study
BACKGROUND Clinical trials that have assessed the effect of revascularization in patients with stable coronary disease have routinely excluded those with advanced chronic kidney disease. METHODS We randomly assigned 777 patients with advanced kidney disease and moderate or severe ischemia on stress testing to be treated with an initial invasive strategy consisting of coronary angiography and revascularization (if appropriate) added to medical therapy or an initial conservative strategy consisting of medical therapy alone and angiography reserved for those in whom medical therapy had failed. The primary outcome was a composite of death or nonfatal myocardial infarction. A key secondary outcome was a composite of death, nonfatal myocardial infarction, or hospitalization for unstable angina, heart failure, or resuscitated cardiac arrest. RESULTS At a median follow-up of 2.2 years, a primary outcome event had occurred in 123 patients in the invasive-strategy group and in 129 patients in the conservative-strategy group (estimated 3-year event rate, 36.4% vs. 36.7%; adjusted hazard ratio, 1.01; 95% confidence interval [CI], 0.79 to 1.29; P=0.95). Results for the key secondary outcome were similar (38.5% vs. 39.7%; hazard ratio, 1.01; 95% CI, 0.79 to 1.29). The invasive strategy was associated with a higher incidence of stroke than the conservative strategy (hazard ratio, 3.76; 95% CI, 1.52 to 9.32; P=0.004) and with a higher incidence of death or initiation of dialysis (hazard ratio, 1.48; 95% CI, 1.04 to 2.11; P=0.03). CONCLUSIONS Among patients with stable coronary disease, advanced chronic kidney disease, and moderate or severe ischemia, we did not find evidence that an initial invasive strategy, as compared with an initial conservative strategy, reduced the risk of death or nonfatal myocardial infarction
Health status after invasive or conservative care in coronary and advanced kidney disease
- Author
- Bangalore S
- Chaitman B.R.
- Chertow G.M.
- Fleg J.L.
- Hochman J.S.
- ISCHEMIA-CKD Research Group: Abdallah M Abdallah Abel E Moreyra, Abhay A Laddu, Abhishek Dubey, Abhishek Goyal, Abigail Knighton, Adedayo Adeboye, Agne Juceviciene, Agne Urboniene, Agnieszka Szramowska, Ahmed Abdel-Latif, Ahmed Ayoub, Ahmed Elghamaz, Ahmed Kamal, Ahmed Talaat, Ajay Sharma, Ajit Singh Narula, Akshay Bagai, Akvile Smigelskaite, Alain Raymond, Alain Rheault, Alaine Melanie Loehr, Albert Varga, Aldo P Maggioni, Alec Moorman, Alejandro Chevaile Ramos, Alejandro Gisbert, Aleksandra Fratczak, Aleksandras Laucevicius, Alexander M Chernyavskiy, Alexander Sergeevich Borisov, Alexandra Craft, Alexandra Hunter, Alexandre Ciappina Hueb, Alexandre Schaan de Quadros, Alice Manica Muller, Aline Peixoto Deiro, Allegra Stone, Almudena Castro, Amar Uxa, Amaryllis Van Craenenbroeck, Ambuj Roy, Amit Kakkar, Amy Flowers, Amy Iskandrian, Ana D Djordjevic-Dikic, Ana Gomes Almeida, Ana Rita Francisco, Ana S Mladenovic, Ana Santana, Anandaroop Lahiri, Anastasia M Kuzmina-Krutetskaya, Anastasia Vamvakidou, Andras Vertes, Andre Gabriel, Andrea Bartykowszki, Andrea Lorimer, Andrea Pascual, Andreia Coelho, Andreia Rocha, Andr\ue9s Garc\ueda-Rinc\uf3n, Andrew Starovoytov, Andrzej \u141abyk, Anelise Kawakami, Angela Hoye, Angelo Nobre, Anjali Acharya, Anjali Anand, Anjana Rishmawi, Ann Banfield, Ann Luyten, Anna Cichocka-Radwan, Anna Fojt, Anna Plachcinska, Anna Teresinska, Anne Marie Webb, Anne Heath, Anoop Mathew, Antonia Vega, Antonio Carvalho, Antonio Colombo, Antonio Fiarresga, Anu Tharini, Anupama Rao, Aquiles Valdespino-Estrada, Ariel Diaz, Arif Asif, Arnold H Seto, Arturo S Campos-Santaolalla, Asim N Cheema, Asker Ahmed, Atul Mathur, Audrey W Leong, Axel \uc5kerblom, Axelle Fuentes, Aynun Naher, Badhma Valaiyapathi, Balaji Srinivasan, Baljeet Kaur, Balram Bhargava, Bandula Guruge, Barbara Wicklund, Bartosz Czarniak, Bebek Singh, Bego\uf1a Igual, Bela Merkely, Benoy N Shah, Bernard de Bruyne, Beth Abramson, Beth Stefanchik, Bethany Harvey, Bharati Shivalkar, Bilal Malik, Binoy Mannekkattukudy Kurian, Bougrida Hammouche, Branko D Beleslin, Bruce Ferguson, Bruce McManus, Bruna Maria Ascoli, Bryn Smith, Byron J Allen, C Michael Gibson, C Noel Bairey Merz, Calin Pop, Carl-\uc9ric Gagn\ue9, Carly Ohmart, Carol M Kartje, Caroline Alsweiler, Caroline Rodgers, Caroline Spindler, Carolyn J Gruber, Catherine Albert, Catherine Bone, Catherine Lemay, Cezary Kepka, Chandini Suvarna, Chantale Mercure, Charlene Wiyarand, Chetan Patel, Chiara Attanasio, Chi-Ming Chow, Ching Min Er, Ching-Ching Ong, Cholenahally Nanjappa Manjunath, Chris Buller, Christel Vassaliere, Christiaan Vrints, Christian Witzke, Christie Ballantyne, Christina Bj\uf6rklund, Christine Roraff, Christophe Laure, Christophe Thuaire, Christopher Chan, Christopher Fordyce, Christopher Kinsey, Chunli Xia, Cidney Schultz, Claes Held, Claudia Cort\ue9s, Claudia Escobar, Cl\ue1udia Freixo, Clemens T Kadalie, Corine Thobois, Courtney Page, Cristina Bare, Dalisa Espinosa, Dan Gao, Dana Rizk, Daniela Puzhevsky, Data Analyst, David M Charytan, David O Williams, David Booth, David Charytan, David Cohen, David DeMets, David Foo, David Goldfarb, David Schlichting, David Sisson, David Taggart, David Waters, David Wheeler, David Williams, Davis Vo, Dawid Teodorczyk, Dawn D Shelstad, Dean Kereiakes, Deborah Yip, Deepa Ramaswamy, Deirdre Mattina, Deirdre Murphy, Dengke Jiang, Derek Cyr, Diana Cukali, Diane Camara, Dimitrios Stournaras, Dipti Patel, Dongze Li, Donna Exley, Doreen Reimann, Doron Schwartz, Duarte Cacela, Dwayne S G Conway, Eapen Punnoose, Edgar L Tay, Edgar Karanjah, Eduardo Gomes Lima, Eduardo Hernandez-Rangel, Edward D Nicol, Edyta Kaczmarska, Elena Refoyo Salicio, Eli Feen, Elih\ufa Dur\ue1n-Cort\ue9s, Elisabeth M Janzen, Elise van Dongen, Elissa Restelli Piloto, Elizabeta Srbinovska Kostovska, Elizabeth Capasso-Gulve, Elizaveta V Zbyshevskaya, Ellie Fridell, Ellis W Lader, Elvira Gosmanova, Emilie Tachot, Emma Howard, Emmanuel Sorbets, Encarnaci\uf3n Alonso-\uc1lvarez, Eric Daugas, Erick Alex\ue1nderson Rosas, Estelle Montpetit, Eugene Passamani, Evgeny Shutov, Ewa Szczerba, Ewelina Wojtala, Expedito Eust\ue1quio Ribeiro Silva, Fabio Fimiani, Fadi Hage, Fahim Haider Jafary, Fang Feng, Fatima Ranjbaran, Fausto J Pinto, Fernando Caeiro, Fernando Nolasco, Filipa Silva, Filippo Ottani, Firas Al Solaiman, Fl\ue1via Egydio, Florina Chereches, Francesca De Micco, Francesca Bianchini, Francesca Pietrucci, Francesco Orso, Francesco Pisano, Francisca Patuleia Figueiras, Fran\ue7ois Madore, Frank Harrell, Frank Rockhold, Frans Van de Werf, Franziska Guenther, Fred Mohr, G Karthikeyan, Gabriel Galeote, Gabriel Grossmann, Gabriel Steg, Gabriela Guzman, Gabriele Gabrielli, Gang Chen, Gautam Sharma, Gaylin Petty, Gelmina Mikolaitiene, Gennie Yee, Gerard Patrick Devlin, Gerard Esposito, Gergely \uc1goston, Gervasio Lamas, Gia Cobb, Gian Piero Perna, Gianpiero Leone, Girish Mishra, Gonzalo Barge-Caballero, Grace M Young, Graciela Scaro, Graham Wong, Gregg Pressman, Gregor Simonis, Gudrun Steinmaurer, Guilherme Portugal, Guilhermina Cantinho Lopes, Guillermo Garcia-Garcia, Guoqin Wang, Gurpreet S Wander, Gurpreet Gulati, Haibo Zhang, Halina Marciniak, Hao Dai, Haojian Dong, Harold Franch, Harvey White, Hatem Elabd, Hayley Pomeroy, Heather Golden, Heidi Wilson, Helene Abergel, Hemalata Siddaram, Hemant Shakhar Mahapatra, Henry C Stokes, Hermine Osseni, Herwig Schuchlenz, Hicham Skali, Holly Mattix-Kramer, Hong Cheng, Hossam Mahrous, Hristo Pejkov, Hugo Marques, Hui Zhong, Hussien El Fishawy, Ian Webb, Iftikhar Kullo, Igor O Grazhdankin, Ikraam Hassan, Ileana L Pina, Ilona Tamasauskiene, In\ueas Zimbarra Cabrita, Ines Rodrigues, Inga Soveri, Irena Peovska Mitevska, Irene Marthe Lang, Irina Subbotina, Irma Kalibataite-Rutkauskiene, Isabelle Roy, Ishita Tejani, Ivan A Naryshkin, Ivana Jankovic, Iwona Niedzwiecka, Jacek Kusmierek, Jackie Chow, Jaekyeong Heo, Jakub Maksym, James E Davies, James J Jang, James Hirsch, James Tatoulis, Jan Henzel, Janaina Oliveira, Janani Rangaswami, Jane Eckstein, Janitha Raj, Jaqueline Pozzibon, Jaroslaw Drozdz, Jason Loh Kwok Kong, Jason T Call, Jason Linefsky, Javier J Garcia, Jay Meisner, Jayne Scales, Jean Michel Juliard, Jean Diodati, Jean-Michel Juliard, Jeanne Russo, Jeannette J M Schoep, Jeff Leimberger, Jeffrey C Milliken, Jeffrey Anderson, Jeffrey Kanters, Jeffrey Lorin, Jeffrey Moses, Jelena J Stepanovic, Jelena Celutkiene, Jelena Stojkovic, Jenne M Jose, Jennifer L Stanford, Jennifer Hogan, Jennifer Horst, Jennifer Isaacs, Jennifer Thomson, Jennifer Tomfohr, Jennifer White, Jerry Yee, Jessica Berg, Jesus Peteiro, Jes\ufas Peteiro, Jia Li, Jiamin Liu, Jianxin Zhang, Jill Marcus, Jim Blankenship, Jing Dong, Jiyan Chen, Jo Evans, Joaqu\uedn V Pe\uf1afiel, Joe Sabik, Johann Christopher, John B Kostis, John Joseph Graham, John Doan, John Jose, John Kotter, John Lehman, John Middleton, John Pownall, Jonathan M Gleadle, Jonathan S Chavez-I\uf1iguez, Jonathan Byrne, Jonathan Himmelfarb, Jonathan Lebowitz, Jonean Thorsen, Jorge Carrillo Calvillo, Jorge Escobedo, Jos\ue9 A Ortega-Ram\uedrez, Jos\ue9 J Cuenca-Castillo, Jose L Diez, Jos\ue9 Luis Narro Villanueva, Jos\ue9 Luiz da Costa Vieira, Jos\ue9 M Flores-Palacios, Jose Fragata, Jose Lopes, Jose Lopez-Sendon, Jos\ue9 Lopez-Sendon, Jose Rueda, Joseph B Selvanayagam, Joseph Sacco, Joshua P Loh, Joy Burkhardt, Juan Manuel L\uf3pez Quijano, Juan Gaztanaga, Judit Sebo, Judith Wright, Juergen Stumpf, Julia de Aveiro Morata, Julio C\ue9sar Figal, Julio Hernandez Jaras, Junqing Yang, Jyotsna Garg, K Manjula Rani, K Preethi, Kaatje Goetschalckx, Karen Calfas, Karen Petrosyan, Karen Servilla, Karen Swan, Karin Ploetze, Karolina Kryczka, Karolina Wojtczak-Soska, Karolina Wojtera, Karthik Ramasamy, Katarzyna \u141uczak, Katarzyna Malinowska, Katharina Knaut, Katherine Martin, Kathleen Claes, Kathryn Mason, Ken Mahaffey, Kenneth Gin, Kerry Lee, Kerstin Bonin, Kerstin Mikes, Kevin R Bainey, Kevin T Harley, Kevin Marzo, Kevin McMahon, Khaled Abdul-Nour, Khaled Alfakih, Khaled Dajani, Khrystyna Kushniriuk, Kian-Keong Poh, Kim Holland, Kimberly E Halverson, Kinnari Murphy, Kiran Reddy, Kirsten J Quiles, Kirsty Abercrombie, Klaus Matschke, Konrad Szymczyk, Koo Hui Chan, Kreton Mavromatis, Krishnakumar Hongalgi, Kristian Thygesen, Kristin M Salmi, Kristin Newby, Kristine Arges, Kristine Teoh, Krzysztof Drzymalski, Lalathaksha Kumbar, Laszlone Matics, LaTonya J Hickson, Laura Keinaite, Laura Sarti, Laura True, Lawrence M Phillips, Lawrence Friedman, Leandro C Maranan, Leda Lotaif, Lekshmi Dharmarajan, Leo A Bockeria, Leonardo Pizzol Caetano, Leonardo Bridi, Leonid L Bershtein, Li Hai Yan, Li Li, Lidia Sousa, Lihong Xu, Lihua Zhang, Lili Zhang, Lilian Mazza Barbosa, Liljana Tozija, Linda Arcand, Lino Patricio, Liping Zhang, Lisa Hatch, Lixin Jiang, Liz Low, Loay Salman, Lorena Lopez, Lori Pritchard, Luis Bernanrdes, Luis Guzman, Lynette L Teo, M Sowjanya Reddy, Maarten Simoons, Maayan Konigstein, Mafalda Selas, Magdalena Madero, Magdalena Miller, Magdalena Misztal-Teodorczyk, Magdy Abdelhamid, Magid Fahim, Mahevamma Mylarappa, Majo X Joseph, Malgorzata Frach, Manjula Rani, Marcello Galvani, Marcin Demkow, Marcin Szkopiak, Marco De Fabritis, Marco Magnoni, Marco Marini, Marco Sicuro, Marek Roik, Maria A Alfonso, Maria Antonieta Pereira de Moraes, Mar\ueda Dolores Mart\uednez-Ru\uedz, Maria Eugenia Canziani, Maria Eugenia Martin, Maria In\ueas Caetano, Maria P Corral, Maria P\ue9rez Garc\ueda, Maria Andreasson, Maria Posada, Marianna D A Dracoulakis, Mariano Rubio, Marija T Petrovic, Marina Vieira, Mario J Garcia, Mario D'arezzo, Maris Orgera, Marius Miglinas, Mark Garand, Mark Peterson, Mark Xavier, Marlowe Mosley, Marta Capinha, Marta Swiderek, Martha Meyer, Martina Ceseri, Martinia Tricoli, Mary Wiilliams, Mary Ann Champagne, Mary Streif, Massoud Leesar, Matei Claudia, Mateusz Solecki, Mat\uedas Nicol\ue1s Mungo, Matthew Shinseki, Matthew Weir, Maura Carina N\ue9dio, Max-Paul Winter, Mayil S Krishnam, Meenakshi Mishra, Mei Hwang, Melemadathil Srilatha, Melissa LeFevre, Mengistu Simegn, Michael A Gibson, Michael B Rubens, Michael D Shapiro, Michael Chobanian, Michael Davidson, Michael Farkouh, Michael Mack, Michal Wlodarczyk, Michel G Khouri, Michelle Crowder, Michelle Ratliff, Miguel Borges Santos, Miguel Nobre Menezes, Miguel Perez Fontan, Miguel Barrero, Mihaly Tapolyai, Mikhail T Torosoff, Milan R Dobric, Milind Avdhoot Gadkari, Min Tun Kyaw, Miri Revivo, Mitchel B Lustre, Mohamed Adel, Mohamed Hassan, Mohammad El-Hajjar, Mohammed Hussain, Mohammed Saleem, Mois\ue9s Blanco-Calvo, Mois\ue9s Jim\ue9nez-Santos, Monika Laukyte, Muhamed Saric, Myrthes Emy Takiuti, Nadia Asif, Nagaraja Moorthy, Naima L Ogletree, Nana O Katamadze, Nandita Nataraj, Naomi Uchida, Nasrul Ismail, Natalia S Oliveira, Natalia de Carvalho Maffei, Nathalie Brosens, Naved Aslam, Naveed Akhtar, Neamat Mowafy, Neeraj Pandit, Neeraj Parakh, Neesh Pannu, Neill Duncan, Nevena Garcevic, Ngaire Meadows, Nicholas Danchin, Nicole Deming, Nikola N Boskovic, Nikolaos Karogiannis, Ning Zhang, Nirmal Kumar, Niruta Sharma, Nitika Chadha, Nitish Naik, Noelle M Durfee, Nora M Cosgrove, Norbert Urbanski, Norma Hogg, Olga Walesiak, Olga Zdo\u144czyk, Olga Zhdanova, Olivia Anaya, Olugbenga Bello, Omar Almousalli, Omar Thompson, Orit Kliuk, Oscar M\ue9ndiz, 3scar Prada-Delgado, Oz Shapira, Pablo Raffaele, Page Salanger, Pal Maurovich-Horvat, Pallav Garg, Paloma Moraga, Pam Singh, Pamela Ouyang, Pamela Woodard, Paola Emanuela Poggio Smanio, Paola Smanio, Paolo Calabro, Patricia K Nguyen, Patricia Alarie, Patricia Carrilho, Patricia Endsley, Patricia Pellikka, Patrycja Lebioda, Paul Der Mesropian, Paul Hauptman, Paula Garc\ueda-Gonz\ue1lez, Paula Wilson, Paulo Cury Rezende, Paulo Novis Rocha, Pedro Canas Silva, Pedro Farto E Abreu, Pedro P\uedccaro de Oliveira, Pedro Carvalho, Pedro Modas, Pedro Rio, Peiyu He, Peter A McCullough, Peter H Stone, Peter Douglass, Peter Sizeland, Peter Voros, Philippe Gabriel Steg, Philippe Genereux, Philippe G\ue9n\ue9reux, Philippe Menasche, Philippe Rheault, Piero Tassinario, Pierre Gervais, Pilar Calvillo, Ping Chai, Piotr Jakubowski, Piotr Pruszczyk, Poay-Huan Loh, Pouneh Samadi, Prakash Deedwania, Pranav M Patel, Praneeth Polamuri, Pratiksha Sharma, Preeti Kamath, Prince Thomas, Priyadarshani Arambam, Puneet Sodhi, Pushpa Naik, Qi Zhong, Qian Zhao, Qianqian Yuan, Qiulan Xie, Rachel Murphy, Radmila Lyubarova, Radmilar Lyubarova, Raewyn Fisher, Rafael Diaz, Rafael Maldonado, Rafael Selgas, Raffaele Bugiardini, Rafia Chaudhry, Raisa Kavalakkat, Rajalekshmi Vs, Rajesh Gopalan Nair, Rajiv Narang, Rakesh Yadav, Ramiro Carvalho, Ramon de Jes\ufas-P\ue9rez, Ran Leng, Ranjan Kachru, Raquel Sanchez, Raven R Dwyer, Raven Lee, Ray Wyman, Raymond C Wong, Reinette Hampson, Renato Abdala Karam Kalil, Renato D Lopes, Renato George Eick, Renato Lopes, Reshma Ravindran, Reto Andreas Gamma, Ricardo Costa, Richa Bhatt, Richard H J Trimlett, Risha Patel, Rita Coram, Robert K Riezebos, Robert M Donnino, Robert Guyton, Robert Harrington, Robert Malecki, Roberto Ren\ue9 Favaloro, Robyn Elliott, Rodolfo G S D Lima, Rohit Tandon, Rolf Doerr, Roma Tewari, Ron Wald, Rongrong Hu, Rory Collins, Roxana Mehran, Roxy Senior, Rub\ue9n Bale\uf3n-Espinosa, Ruben Ramos, Rui Ferreira, Ruth Kirby, Ruth P\ue9rez-Fern\ue1ndez, S Ramakrishnan, S K Dwivedi, Sadath Lubna, Sadiq Ahmed, Sajeev Chakanalil Govindan, Salamah Alfalahi, Salvador Cruz-Flores, Salvatore P Costa, Sampoornima Setty, Samuel Nwosu, Sandeep Mahajan, Sandeep Seth, Sandeep Singh, Sander R Niehe, Sandy Carr, Sanja Simic Ogrizovic, Sanja Ogrizovic, Sanjeev Gulati, Sanjeev Sharma, Sara Fernandez, Sarah Williams, Sarju Ralhan, Sasko Kedev, Satinder Singh, Satish Sankaranarayanan, Satvic Cholenahally Manjunath, Sau Lee, Schawana Thaxton, Sean M O'Brien, Sebastian Sobczak, Seema Nour, Sergey A Sayganov, S\ue9rgio Bravo Baptista, Sergio Draibe, Seth Sokol, Sharad Chandra, Shari Mackedanz, Shaun Goodman, Shayan Shirazian, Sheetal Rupesh Karwa, Sheri Ussery, Sheromani Bajaj, Shirin Heydari, Shiv Kumar Choudhary, Shivali Patel, Shruti Pandey, Shuyang Zhang, Siddharth Gadage, Sik-Yin V Tan, S\uedlvia Zottis Poletti, Silvia Valbuena, Simone Savaris, Solomon Yakubov, Songlin Zhu, Sonika Gupta, Sorin Brener, Sothinathan Gurunathan, Soundarya Nayak, Sowjanya Reddy, Stanley E Cobos, Stefan Weikl, Stephanie M Lane, Stephanie Ferket, Stephanie Mavromichalis, Stephen Fremes, Steven A Fein, Steven P Sedlis, Steven Giovannone, Steven Weitz, Subhash Banerjee, Sudhanva S Hegde, Suellen Hosino, Sulagna Mookherjee, Suman Singh, Sumith Abeygunasekara, Sundeep Mishra, Sunil Kumar Verma, Suresh Kumar, Suryaprakash Narayanappa, Susan K Milbrandt, Susana Silva, Susanna Stevens, Suvarna Kolhe, Suzana Tavares, Suzanne Welsh, T A Kishore, Tamara Colai\ue1covo Soares, Tapan Umesh Pillay, Tarek Rashid, Tarun K Mittal, Tauane Bello Duarte, T\ue9odora Dutoiu, Teresa Delgadillo, Terrance Chua, Terrance Welch, Theodoros Kofidis, Thierry Lefevre, Tiago Silva, Timea Boros, Titus Lau, Tiziana Formisano, Tomasz Ciurus, Tomasz Tarchalski, Tracy Tan, Umesh Lingaraj, V K Bahl, V S Narain, Valentina Pellu, Valentine Lobo, Valerie Robesyn, Vandana Yadav, Veerabhadra Gupta, Verghese Mathew, Vicente Miro, Victoria Gumerova, Victoria Hernandez, Vijay Kher, Vijay Kumar, Vikas Makkar, Vikranth Reddy, Viktoria Bulkley, Vinoi George David, Virendra Misra, Virginia Fern\ue1ndez-Figares, Vladimir Ryasniansky, Vojislav L Giga, Wael A Almahmeed, Wan Xian Chan, Wanda C Marfori, Wanda Parker, Wayne Pennachi, Wei Ling Lau, Weibing Xing, Weijing Bian, Wendy L Stewart, Wendy Drewes, Whady Hueb, William Weintraub, Winnie C Sia, Xacobe Flores-R\uedos, Xiang Ma, Xiangqiong Gu, Xiaomei Li, Xiaoyi Xu, Xin Fu, Xuemei Li, Xutong Wang, Yanek P\ue9pin-Dubois, Yaron Arbel, Yechen Han, Yiming Lit, Ying Tung Sia, Ying Wang, Yining Yang, Yitong Ma, Yolayfi Peralta, Yves Smets, Yvonne Taul, Zalina Kudzoeva, Zeljko Z Markovic, Zhangsuo Liu, Zhenyu Liu, Zhiming Ye, Zixiang Yu, Zoltan Davidovits, Zvezdana Petronijevic
- Jones P.G.
- Mark D.B.
- Maron D.J.
- O'Brien S.M.
- Reynolds H.R.
- Sidhu M.S.
- Spertus J.A.
- Stone G.W.
- Publication venue
- 'Massachusetts Medical Society'
- Publication date
- 01/01/2020
- Field of study
BACKGROUND In the ISCHEMIA-CKD trial, the primary analysis showed no significant difference in the risk of death or myocardial infarction with initial angiography and revascularization plus guideline-based medical therapy (invasive strategy) as compared with guideline-based medical therapy alone (conservative strategy) in participants with stable ischemic heart disease, moderate or severe ischemia, and advanced chronic kidney disease (an estimated glomerular filtration rate of <30 ml per minute per 1.73 m2 or receipt of dialysis). A secondary objective of the trial was to assess angina-related health status. METHODS We assessed health status with the Seattle Angina Questionnaire (SAQ) before randomization and at 1.5, 3, and 6 months and every 6 months thereafter. The primary outcome of this analysis was the SAQ Summary score (ranging from 0 to 100, with higher scores indicating less frequent angina and better function and quality of life). Mixed-effects cumulative probability models within a Bayesian framework were used to estimate the treatment effect with the invasive strategy. RESULTS Health status was assessed in 705 of 777 participants. Nearly half the participants (49%) had had no angina during the month before randomization. At 3 months, the estimated mean difference between the invasive-strategy group and the conservative-strategy group in the SAQ Summary score was 2.1 points (95% credible interval, 120.4 to 4.6), a result that favored the invasive strategy. The mean difference in score at 3 months was largest among participants with daily or weekly angina at baseline (10.1 points; 95% credible interval, 0.0 to 19.9), smaller among those with monthly angina at baseline (2.2 points; 95% credible interval, 122.0 to 6.2), and nearly absent among those without angina at baseline (0.6 points; 95% credible interval, 121.9 to 3.3). By 6 months, the between-group difference in the overall trial population was attenuated (0.5 points; 95% credible interval, 122.2 to 3.4). CONCLUSIONS Participants with stable ischemic heart disease, moderate or severe ischemia, and advanced chronic kidney disease did not have substantial or sustained benefits with regard to angina-related health status with an initially invasive strategy as compared with a conservative strategy
Health-status outcomes with invasive or conservative care in coronary disease
- Author
- Alexander K.P.
- Baloch K.
- Bangalore S.
- Boden W.E.
- Cohen D.J.
- Diaz A.
- Gosselin G.
- Harrell F.E.
- Hochman J.S.
- ISCHEMIA Research Group: Joseph Ricci A Tello Montoliu, A I Robero Aniorte, Abbey Mulder, Abhay A Laddu, Abhinav Goyal, Abhishek Dubey, Abhishek Goyal, Abigail Knighton, Abraham Oomman, Adam J Jaskowiak, Adam Kolodziej, Adam Witkowski, Adnan Hameed, Adriana Anesini, Afshan Hussain, Agne Juceviciene, Agne Urboniene, Agnes Jakal, Agnieszka Szramowska, Ahmad Khairuddin, Ahmed Abdel-Latif, Ahmed Adel, Ahmed Aljzeeri, Ahmed Kamal, Ahmed Talaat, Aimee Mann, Aira Contreras, Ajit Kumar, V K Kumar, Akemi Furukawa, Akshay Bagai, Akvile Smigelskaite, Alain Furber, Alain Rheault, Alaine Melanie Loehr, Alan Rosen, Albert Varga, Albertina Qelaj, Alberto Barioli, Aldo Russo, Alec Moorman, Alejandro Gisbert, Aleksandra Fratczak, Aleksandras Laucevicius, Alena Kuleshova, Alessandro Sionis, Alexander A Sirker, Alexander M Chernyavskiy, Alexandra Craft, Alexandra Vazquez, Alexandre Ciappina Hueb, Alexandre S Colafranseschi, Alexandre Schaan de Quadros, Alexandre Tognon, Ali Alghamdi, Alice Manica Muller, Aline Nogueira Raba\ue7a, Aline Peixoto Deiro, Alison Hallam, Allegra Stone, Allison Schley, Almudena Castro, Alvaro Rabelo Ales, Amanda Germann, Amanda O'Malley, Amar Uxa, Amarachi Ojajuni, Amarino C Oliveira Jr, Amber B Hull, Ambuj Roy, Amer Zarka, Amir Janmohamed, Ammani Brown, Ammy Malinay, Amparo Martinez Monzonis, Amy J Richards, Amy Iskandrian, Amy Ollinger, Ana D Djordjevic-Dikic, Ana Fern\ue1ndez Mart\uednez, Ana Gomes Almeida, Ana Paula Batista, Ana Rita Francisco, Ana S Mladenovic, Ana Santana, Anam Siddiqui, Anastasia M Kuzmina-Krutetskaya, Andras Vertes, Andre S Sousa, Andre Gabriel, Andr\ue9 Schmidt, Andrea M Lundeen, Andrea Bartykowszki, Andrea Lorimer, Andrea Mortara, Andrea Pascual, Andreia Coelho, Andreia Rocha, Andr\ue9s Garc\ueda-Rinc\uf3n, Andrew G Howarth, Andrew J Moriarty, Andrew Docherty, Andrew Starovoytov, Andrew Zurick, Andrzej \u141abyk, Andrzej Swiatkowski, Andy Lam, Anelise Kawakami, Angela Hoye, Angela Kim, Angelique Smit, Angelo Nobre, Anil V Shah, Anja Ljubez, Anjali Anand, Ankush Sachdeva, Ann Greenberg, Ann Luyten, Ann Ostrander, Anna Di Donato, Anna Cichocka-Radwan, Anna Fojt, Anna Plachcinska, Anna Proietti, Anna Teresinska, Anne Marie Webb, Anne Cartwright, Anne Heath, Anne Mackin, Anong Amaritakomol, Anong Chaiyasri, Anoop Chauhan, Anoop Mathew, Anthony Gemignani, Anto Luigi Andres, Antonia Vega, Antonietta Hansen, Antonino Ginel Iglesias, Antonio Carlos Carvalho, Antonio Di Chiara, Antonio Serra Pe\uf1aranda, Antonio Carvalho, Antonio Colombo, Antonio Fiarresga, Anupama Rao, Aquiles Valdespino-Estrada, Araceli Boan, Areef Ishani, Ariel Diaz, Arijit Ghosh, Arintaya Prommintikul, Arline Roberts, Arnold H Seto, Arnold P Good, Arshed Quyyumi, Arthur J Labovitz, Arthur Kerner, Arturo S Campos-Santaolalla, Arunima Misra, Ashok Mukherjee, Ashok Seth, Ashraf Seedhom, Asim N Cheema, Asker Ahmed, Atul Mathur, Atul Verma, Audrey W Leong, Axel \uc5kerblom, Axelle Fuentes, Aynun Naher, Badhma Valaiyapathi, Baljeet Kaur, Bandula Guruge, Barbara Brzezi\u144ska, Barbara Nardi, Bartosz Czarniak, Bebek Singh, Bego\uf1a Igual, Bela Merkely, Belen Cid Alvarez, Benjamin J Spooner, Benjamin J W Chow, Benjamin Cheong, Benoy N Shah, Bernard de Bruyne, Bernardas Valecka, Bernhard J\ue4ger, Beth A Archer, Beth Abramson, Beth Jorgenson, Bethany Harvey, Betsy O'Neal, Bev Atkinson, Bev Bozek, Bevin Lang, Bijulal Sasidharan, Bin Yang, Bin Zhang, Binoy Mannekkattukudy Kurian, Bjoern Goebel, Bob Hu, Bogdan A Popescu, Bogdan Crnokrak, Bolin Zhu, Bonnie J Kirby, Brandi D Zimbelman, Brandy Starks, Branko D Beleslin, Brenda Hart, Brian P Shapiro, Brian McCandless, Brianna Wisniewski, Brigham R Smith, Brooks Mirrer, Bruce McManus, Bruce Rutkin, Bruna Edilena Paulino, Bruna Maria Ascoli, Bryn Smith, Byron J Allen, C Michael Gibson, C Noel Bairey Merz, Calin Pop, Cameron Hague, Camila Thais de Ormundo, Candace Gopaul, Candice P Edillo, Car\uedsi A Polanczyk, Carita Krannila, Carla Vicente, Carl-\uc9ric Gagn\ue9, Carlo Briguori, Carlos Pe\uf1a Gil, Carlos Alvarez, Carly Ohmart, Carmen C Beladan, Carmen Ginghina, Carol M Kartje, Caroline Alsweiler, Caroline Brown, Caroline Callison, Caroline Pinheiro, Caroline Rodgers, Caroline Spindler, Carolyn Corbett, Carrie Drum, Casey Riedberger, Catherine Bone, Catherine Fleming, Catherine Gordon, Catherine Jahrsdorfer, Catherine Lemay, Catherine Weick, Cathrine Patten, Cecilia Goletto, Cezary Kepka, Chandini Suvarna, Chang Xu, Chantale Mercure, Charle A Viljoen, Charlene Wiyarand, Charles Jia-Yin Hou, Charles Y Lui, Charles Cannan, Charles Cornet, Charlotte Pirro, Chataroon Rimsukcharoenchai, Chen Wang, Cheng-Ting Tsai, Chen-Yen Chien, Cheryl A Allardyce, Chester M Hedgepeth, Chetan Patel, Chiara Attanasio, Chih-Hsuan Yen, Chi-Ming Chow, Ching Min Er, Ching-Ching Ong, Cholenahally Nanjappa Manjunath, Chris Beck, Chris Buller, Christel Vassaliere, Christian Hamm, Christiano Caldeira, Christie Ballantyne, Christina Bj\uf6rklund, Christine R Hinton, Christine Bergeron, Christine Masson, Christine Roraff, Christine Shelley, Christophe Laure, Christophe Thuaire, Christopher Kinsey, Christopher McFarren, Christopher Spizzieri, Christopher Travill, Chun-Chieh Liu, Chung-Lieh Hung, Chunguang Li, Chun-Ho Yun, Chunli Xia, Ciarra Heard, Cidney Schultz, Clare Venn-Edmonds, Claudia P Hochberg, Claudia Wegmayr, Claudia Cort\ue9s, Claudia Escobar, Cl\ue1udia Freixo, Claudio T Mesquita, Clemens T Kadalie, Colin Berry, Constance Philander, Corine Thobois, Costantino Costantini, Courtney Page, Craig Atkinson, Craig Barr, Craig Paterson, Cristina Bare, Cynthia Baumann, Cynthia Burman, Dalisa Espinosa, Damien Collison, Dan Deleanu, Dan Elian, Dan Gao, Dana Oliver, Daniel P Vezina, Daniel O'Rourke, Daniele Komar, Danielle Schade, Darrel P Francis, Dastan Malaev, David A Bull, David E Winchester, David P Faxon, David Booth, David Cohen, David DeMets, David Foo, David Schlichting, David Taggart, David Waters, David Wohns, Davis Vo, Dawid Teodorczyk, Dawn Shelstad, Dawn Turnbull, Dayuan Li, Dean Kereiakes, Deborah O'Neill, Deborah Yip, Debra K Johnson, Debra Dees, Deepak L Bhatt, Deepika Gopal, Deepti Kumar, Deirdre Mattina, Deirdre Murphy, Delano R Small, Delsa K Rose, Dengke Jiang, Denis Carl Phaneuf, Denise Braganza, Denise Fine, Derek Cyr, Desiree Tobin, Diana Cukali, Diana Parra, Diane Camara, Diane Minshall Liu, Diego Adri\ue1n Vences, Diego Franca de Cunha, Dimitrios Stournaras, Dipti Patel, Dongze Li, Donna Exley, Dorit Grahl, Dragana Stanojevic, Duarte Cacela, Dwayne S G Conway, E Pinar Bermudez, Eapen Punnoose, Edgar L Tay, Edgar Karanjah, Edoardo Verna, Eduardo Hernandez-Rangel, Edward D Nicol, Edward O McFalls, Edward T Martin, Edyta Kaczmarska, Ekaterina I Lubinskaya, Elena A Demchenko, Elena Refoyo Salicio, Eli Feen, Elih\ufa Dur\ue1n-Cort\ue9s, Elisabeth M Janzen, Elise L Hannemann, Elise van Dongen, Elissa Restelli Piloto, Eliza Kaplan, Elizabeta Srbinovska Kostovska, Elizabeth Capasso-Gulve, Elizabeth Congdon, Elizabeth Ferguson, Elizaveta V Zbyshevskaya, Ellen Magedanz, Ellie Fridell, Ellis W Lader, Elvin Kedhi, Emanuela Racca, Emilie Tachot, Emily DeRosa, Encarnaci\uf3n Alonso-\uc1lvarez, Eric Nicollet, Eric Peterson, Erick Alex\ue1nderson Rosas, Erick Donato Morales, Erin Orvis, Ermina Moga, Estelle Montpetit, Estevao Figueiredo, Eugene Passamani, Eugenia Nikolsky, Eunice Yeoh, Evgeniy I Kretov, Ewa Szczerba, Ewelina Wojtala, Expedito Eust\ue1quio Ribeiro Silva, F Marin Ortu\uf1o, Fabio R Farias, Fabio Fimiani, Fabrizio Rolfo, Fa-Chang Yu, Fadi Hage, Fadi Matar, Fahim Haider Jafary, Fang Feng, Fang Liu, Fatima Ranjbaran, Fatima Rodriguez, Fausto J Pinto, Fauzia Rashid, Federica Ramani, Fei Wang, Fernanda Igansi, Filipa Silva, Filippo Ottani, Fiona Haines, Firas Al Solaiman, Fl\ue1via Egydio, Flavio Lyra, Florian Egger, Fran Farquharson, Frances Laube, Francesc Carreras Costa, Francesca de Micco, Francesca Bianchini, Francesca Pezzetta, Francesca Pietrucci, Francesco Orso, Francesco Pisano, Francis Burt, Francisca Patuleia Figueiras, Francisco Fernandez-Aviles, Francois Pierre Mongeon, Frans Van de Werf, Franziska Guenther, Fraser N Witherow, Fred Mohr, Frederico Dall'Orto, Fumiyuki Otsuka, G De La Morena, G Karthikeyan, Gabor Dekany, Gabor Kerecsen, Gabriel Galeote, Gabriel Grossmann, Gabriel Vorobiof, Gabriela Sanchez de Souza, Gabriela Guzman, Gabriela Zeballos, Gabriele Gabrielli, Gabriele Jakl-Kotauschek, Gail A Shammas, Gail Brandt, Gang Chen, Gary E Lane, Gary J Luckasen, Gautam Sharma, Gelmina Mikolaitiene, Gennie Yee, Georg Nickenig, George E Revtyak, George J Juang, Gerald Fletcher, Gerald Leonard, Gerard Patrick Devlin, Gerard Esposito, Gergely \uc1goston, Gervasio Lamas, Geza Fontos, Ghada Mikhail, Gia Cobb, Gian Piero Perna, Gianpiero Leone, Giles Roditi, Gilles Barone-Rochette, Girish Mishra, Giuseppe Tarantini, Glenda Wong, Glenn S Hamroff, Glenn Rayos, Gong Cheng, Gonzalo Barge-Caballero, Goran Davidovi\u107, Goran Stankovic, Gordana Stevanovic, Grace Jingyan Wang, Grace M Young, Graceanne Wayser, Graciela Scaro, Graham S Hillis, Graham Wong, Grazyna Anna Szulczyk, Gregor Simonis, Gregory Kumkumian, Gretchen Ann Peichel, Grzegorz Gajos, Gudrun Steinmaurer, Guilherme G Rucatti, Guilherme Portugal, Guilhermina Cantinho Lopes, Guillem Pons Llad\uf3, Gunnar Frostfelt, Gurpreet S Wander, Gurpreet Gulati, Gustavo Pucci, Hafidz Abd Hadi, Haibo Zhang, Haitao Wang, Halina Marciniak, Han Chen, Hanan Kerr, Hani Najm, Hanna Douglas, Hannah Phillips, Hao Dai, Haojian Dong, Haqeel Jamil, Harikrishnan Sivadasanpillai, Harry Suryapranata, Hassan Reda, Hayley Pomeroy, Heather Barrentine, Heather Golden, Heather Hurlburt, Heidi Wilson, Helen C Tucker, Helene Abergel, Hemalata Siddaram, Hermine Osseni, Herwig Schuchlenz, Hesong Zeng, Hicham Skali, Hilda Solomon, Hollie Horton, Holly Hetrick, Holly Little, Holly Park, Hongjie Chi, Hossam Mahrous, Howard A Levite, Hristo Pejkov, Huajun Li, Hugo Bloise-Adames, Hugo Marques, Hui Zhong, Hui-Min Zhang, Humayrah Hashim, Hung-I Yeh, Hussien El Fishawy, Ian Webb, Iftikhar Kullo, Igor O Grazhdankin, Ihab Hamzeh, Ikraam Hassan, Ikuko Ueda, Ileana L Pina, Ilona Tamasauskiene, Ilse Bouwhuis, Imran Arif, Ina Wenzelburger, In\ueas Zimbarra Cabrita, Ines Rodrigues, Inga H Robbins, Inga Soveri, Ingela Schnittger, Iqbal Karimullah, Ira M Dauber, Iram Rehman, Irena Peovska Mitevska, Irene Marthe Lang, Irina Subbotina, Irma Kalibataite-Rutkauskiene, Irni Yusnida, Isabel Estela Carvajal, Isabella C Palazzo, Isabelle Hogan, Isabelle Roy, Ishba Syed, Ishita Tejani, Ivan A Naryshkin, Ivana Jankovic, Iwona Niedzwiecka, J David Knight, Jacek Kusmierek, Jackie M White, Jackie Chow, Jacob Udell, Jacqueline E Tamis-Holland, Jacqueline Fannon, Jacquelyn A Quin, Jacquelyn Do, Jaekyeong Heo, Jakub Maksym, James E Davies, James H O'Keefe Jr, James J Jang, James Cha, James Harrison, James Hirsch, James Stafford, James Tatoulis, Jamie Rankin, Jan Henzel, Jan Orga, Jana Tancredi, Janaina Oliveira, Jane Burton, Jane Eckstein, Jane Marucci, Janet P Knight, Janet Blount, Janet Halliday, Janetta Kourzenkova, Janitha Raj, Jan-Malte Sinning, Jaqueline Pozzibon, Jaroslaw Drozdz, Jaroslaw Karwowski, Jason D Glover, Jason Loh Kwok, Jason T Call, Jason Linefsky, Jassira Gomes, Jati Anumpa, Javier J Garcia, Javier Courtis, Jay Meisner, K Jayakumar, Jayne Scales, Jean E Denaro, Jean Michel Juliard, Jean Ho, Jeanette K Stansborough, Jean-Michel Juliard, Jeanne Russo, Jeannette J M Schoep, Jeet Thambyrajah, Jeff Leimberger, Jeffery A Breall, Jeffrey A Kohn, Jeffrey C Milliken, Jeffrey Anderson, Jeffrey Blume, Jeffrey Kanters, Jeffrey Lorin, Jeffrey Moses, Jelena J Stepanovic, Jelena Celutkiene, Jelena Djokic, Jelena Stojkovic, Jenne M Jose, Jenne Manchery, Jennifer A Mull, Jennifer H Czerniak, Jennifer L Stanford, Jennifer Gillis, Jennifer Horst, Jennifer Isaacs, Jennifer Langdon, Jennifer Thomson, Jennifer Tomfohr, Jennifer White, Jen-Yuan Kuo, Jeremy Rautureau, Jerome Fleg, Jessica Berg, Jessica Rodriguez, Jessica Waldron, Jhina Patro, Jia Li, Jiajia Mao, Jiamin Liu, Jian'an Wang, Jianhua Li, Jianxin Zhang, Jie Qi, Jihyun Lyo, Jill Marcus, Jim Blankenship, Jing Zhang, Jingjing Liu, Jing-Yao Fan, Jiun-Yi Li, Jiwan Pradhan, Jiyan Chen, J M Rivera Caravaca, Jo Evans, Joan Garcia Picart, Joan Hecht, Joanna Jaroch, Joanna Zalewska, Joanne Kelly, Joanne Taaffe, Jo\ue3o Reynaldo Abbud, Jo\ue3o V Vitola, Joaqu\uedn V Pe\uf1afiel, Jocelyne Benatar, Jody Bindeman, Joe Sabik, Joel Klitch, Johann Christopher, Johannes Aspberg, John D Friedman, John F Beltrame, John F Heitner, John Joseph Graham, John R Davies, John Doan, John Kotter, John Kurian, John Mukai, John Pownall, Jolanta Sobolewska, Jon Kobashigawa, Jonathan L Goldberg, Jonathan W Bazeley, Jonathan Byrne, Jonathan Himmelfarb, Jonathan Leipsic, Jonean Thorsen, Jorge F Trejo Gutierrez, Jorge Escobedo, Jorik Timmer, Jos\ue9 A Ortega-Ram\uedrez, Jos\ue9 Antonio Marin-Neto, Jose D Salas, Jose Enrique Castillo, Jose Francisco Saraiva, Jos\ue9 J Cuenca-Castillo, Jose L Diez, Jos\ue9 Luis Narro Villanueva, Jos\ue9 Luiz da Vieira, Jos\ue9 M Flores-Palacios, Jose Ramon Gonzalez, Jose Seijas Amigo, Jose Fragata, Josep Maria Padr\uf3, Josheph F X McGarvey Jr, Joseph Hannan, Joseph Sacco, Joseph Sweeny, Joseph Wiesel, Josephine D Abraham, Joshua P Loh, Joy Burkhardt, Joyce R White, Joyce Riestenberg-Smith, Judit Sebo, Judith L Meadows, Judith Wright, Judy Mae Foltz, Judy Hung, Judy Otis, Juergen Stumpf, Jui-Peng Tsai, Julia S Dionne, Julia de Aveiro Morata, Julie Bunke, Julie Morrow, Julio C\ue9sar Figal, Jun Fujita, Jun Jiang, Junhua Li, Junqing Yang, Juntima Euathrongchit, Jyotsna Garg, K Manjula Rani, K Preethi, Kaatje Goetschalckx, Kai Eggers, Kamalakar Surineni, Kanae Hirase, T R Kapilamoorthy, Karen Calfas, Karen Gratrix, Karen Hallett, Karen Hultberg, Karen Nugent, Karen Petrosyan, Karen Swan, Karolina Kryczka, Karolina Wojtczak-Soska, Karolina Wojtera, Karsten Lenk, Karthik Ramasamy, Katarzyna \u141uczak, Katarzyna Malinowska, Kate Pointon, Kate Robb, Katherine Martin, Kathleen Claes, Kathryn Carruthers, Kathy E Siegel, Katia Drouin, Katie Fowler-Lehman, Kavita Rawat, Kay Rowe, Keiichi Fukuda, Keith A A Fox, Ken Mahaffey, Kendra Unterbrink, Kenneth Giedd, Kerrie Van Loo, Kerry Lee, Kerstin Bonin, Kevin R Bainey, Kevin T Harley, Kevin Anstrom, Kevin Chan, Kevin Croce, Kevin Landolfo, Kevin Marzo, Keyur Patel, Khaled Abdul-Nour, Khaled Alfakih, Khaled Dajani, Khaled Ziada, Khaula Baloch, Khrystyna Kushniriuk, Kian-Keong Poh, Kim F Ireland, Kim Holland, Kimberly Ann Byrne, Kimberly E Halverson, Kimberly Elmore, Kimberly Miller-Cox, Kiran Reddy, Kirsten J Quiles, Kirsty Abercrombie, Klaus Matschke, Konrad Szymczyk, Koo Hui Chan, Kotiboinna Preethi, Kozhaya Sokhon, Krissada Meemuk, Kristian Thygesen, Kristin M Salmi, Kristin Newby, Kristina Wippler, Kristine Arges, Kristine Teoh, Krystal Etherington, Krystyna \u141oboz-Grudzie\u144, Krzysztof W Reczuch, Krzysztof Bury, Krzysztof Drzymalski, Krzysztof Kuku\u142a, Kuo-Tzu Sung, Kurt Huber, Ladda Douangvila, Lance Sullenberger, Larissa Miranda Trama, Laszlone Matics, Laura Drew, Laura Flint, Laura Keinaite, Laura Sarti, Laurel Kolakaluri, Lawrence M Phillips, Lawrence Friedman, Lawrence Phillips, Lazar Velicki, Leah Howell, Leandro C Maranan, Leanne Cox, Ledjalem Daba, Lei Zhang, Lekshmi Dharmarajan, Leo Bockeria, Leonardo Pizzol Caetano, Leonardo Bridi, Leonid L Bershtein, Leszek Sokalski, Li Hai Yan, Li Li, Lia Nijmeijer, Lidia Sousa, Lihong Xu, Lihua Zhang, Lili Zhang, Lilia Schiavi, Lilian Mazza Barbosa, Lillian L Khor, Lina Felix-Stern, Linda L Hall, Linda M Hollenweger, Linda Arcand, Linda Davidson-Ray, Linda Schwarz, Lindsey N Sikora, Lingping Chi, Lino Patricio, Liping Zhang, Lisa Chaytor, Lisa Hatch, Lisa McCloy, Lisa Wong, Liselotte Persson, Lixin Jiang, Liz Low, Ljiljana Pupic, Lo\uefc Bi\ue8re, Lorenzo Monti, Lori Christensen, Lori Pritchard, Loriane Black, Lori-Ann Desimone, Lori-Ann Larmand, Lorraine McGregor, Louise Morby, Louise Thomson, Luc Harvey, Luciana de P\ue1dua Baptista, Lucilla Garcia, Ludivine Eliahou, Ludmila Helmer, Luis F Smidt, Luis Bernanrdes, Luis Guzman, Luiz A Carvalho, Luyang Xiong, Lynette L Teo, Lynn M Neeson, Lynne Winstanley, M Barbara Srichai-Parsia, M Quintana Giner, M Sowjanya Reddy, M Vald\ue9s Ch\ue1varri, M Grazia Rossi, Maarten Simoons, Maayan Konigstein, Maciej Lesiak, Maciej Olsowka, Mafalda Selas, Magalie Corfias, Magdalena Madero Rovalo, Magdalena \u141anocha, Magdalena Miller, Magdalena Misztal-Teodorczyk, Magdalena Rantinella, Magdy Abdelhamid, Magnolia Jimenez, Mahboob Alam, Mahevamma Mylarappa, Mahfouz El Shahawy, Mahmoud Mohamed, Mahmud Al-Bustami, Majo X Joseph, Malgorzata Frach, Ma\u142gorzta Celi\u144ska-Spodar, Malte Helm, Manas Chacko, Mandy Murphy, Manitha Vinod, Manjula Rani, Manu Dhawan, Manuela Mombelli, Marcel Weber, Marcello Galvani, Marcelo Jamus Rodrigues, Marcia F Dubin, Marcia F Werner Bayer, Marcin Szkopiak, Marco Antonio Monsalve, Marco Bizzaro Santos, Marco Magnoni, Marco Marini, Marco Sicuro, Marco Zenati, Marcos Val\ue9rio Coimbra Resende, Marek Roik, Margalit Bentzvi, Margaret Gilsenan, Margaret Iraola, Margot C Quinn, Maria A Alfonso, Maria Antonieta Pereira Moraes, Mar\ueda Dolores Mart\uednez-Ru\uedz, Mar\ueda Fernanda Canales, Maria In\ueas Caetano, Maria P Corral, Maria P\ue9rez Garc\ueda, Maria Victoria Actis, Maria Aguirre, Maria Andreasson, Maria Aprile, Maria Colton, Maria Eugenia Martin, Maria Lasala, Maria Lorenzo, Maria Posada, Maria Shier, Maria Thottam, Mariana V Furtado, Mariana Yumi Okada, Marianna D A Dracoulakis, Marianne De Andrade, Mariano Rubio, Marie Essermark, Marielle Scherrer-Crosbie, Marija T Petrovic, Marija Zdravkovic, Marilyn Black, Marina Garcia, Mario J Garcia, Mariola Szulik, Marisa Orgera, Mark A de Belder, Mark Harbinson, Mark Hyun, Mark Peterson, Mark Xavier, Marlowe Mosley, Marta Capinha, Marta Marcinkiewicz-Siemion, Marta Swiderek, Martha Meyer, Martina Ceseri, Martina Tricoli, Marvin Kronenberg, Mary Williams, Mary Ann Champagne, Mary Colleen Rogge, Mary R Soltau, Mary Streif, Massimo Villella, Massoud Leesar, Matei Claudia, Mateusz Solecki, Mat\uedas Nicol\ue1s Mungo, Matthew Wall Jr, Matthew Budoff, Matthew Jezior, Matthew Luckie, Matthias Friedrich, Mauren P Haeffner, Maximilian Tscharre, Max-Paul Winter, Mayana Almeida, Mayil S Krishnam, Mayuri Patel, Meenakshi Mishra, Megan Manocchia, Meghana Kakade, Melanie J Munro, Melissa D Chaplin, Melissa LeFevre, Mervyn Andiapen, Michael A Gibson, Michael B Rubens, Michael C Turner, Michael D Shapiro, Michael W Lee, Michael Berlowitz, Michael Davidson, Michael Mack, Michael McDaniel, Michael Mumma, Michal Wlodarczyk, Michel G Khouri, Michel S Slama, Michele Rawlins, Michelle M Bonner, Michelle M Seib, Michelle Chang, Michelle Crowder, Michelle Dixon, Michelle Mayon, Michelle McEvoy, Michelle Yee, Miguel M Fernandes, Miguel Nobre Menezes, Miguel Souto Bayarri, Miguel Barrero, Mikhail T Torosoff, Milan R Dobric, Milan Dobric, Milica Nikola Dekleva, Milind Avdhoot Gadkari, Millie Gomez, Min Tun Kyaw, Miriam Brooks, Miroslav Stevo Martinovic, Mitchel B Lustre, Mohammad Tariq Vakani, Mohammad El-Hajjar, Mohammed Al-Amoodi, Mohammed Hussain, Mohammed Saleem, Mois\ue9s Blanco-Calvo, Mois\ue9s Jim\ue9nez-Santos, Mona Bhatia, Monica Rosca, Monika Laukyte, Montserrat Gracida Blanca, Montserrat Vila Perales, Mouaz H Al-Mallah, Moys\ue9s de Oliveira Filho, Mpiko Ntsekhe, Muhamed Saric, Mulei Chen, Myriam Brousseau, Myrthes Emy Takiuti, Nada Cemerlic-Adjic, Nadia Asif, Nadia Gakou, Nafisa Hussain, Nana O Katamadze, Nancy L Clapp, Nancy Aedy, Nandita Nataraj, Nanette K Wenger, Naomi Uchida, Nasrul Ismail, Natalia S Oliveira, Natalia de Carvalho Maffei, Natalie Spitzer, Natasha C Putnam, Naved Aslam, Neamat Mowafy, Neeraj Pandit, Neeraj Parakh, Nevena Garcevic, Ngaire Meadows, Nhi N Tran, Nicholas Danchin, Nicki Lakeman, Nicola Johnston, Nicolas W Shammas, Nicole Saint Vrestil, Nicole Deming, Nier Zhong, Niket Patel, Nikola N Boskovic, Nikolaos Karogiannis, Nikos Werner, Nina Johnston, Ning Zhang, Ning Zhou, Niree Hindoyan, Nirmal Kumar, Nitika Chadha, Nitish Naik, Nodira Aripova, Noloyiso Mtana, Nona A Eskelson, Noor Syamira Mokhtar, Noppon Taksaudom, Nor Asiah Basri, Nora Marchelletta, Norma Hogg, Nungshi Jungla, Nuno Ferreira, Oksana A Lubyanaya, Olga B Nikolaeva, Olga Ca\uf1avate, Olga Sobrino, Olga Walesiak, Olga Walter, Olga Zdo\u144czyk, Olivia J Lim, Olivia Anaya, Olivia Mancilla, Olivier Dubourg, Olugbenga Bello, Omar Almousalli, Omar Thompson, Oni Olurinde, Or Harel, Osama Raheem, Oscar M\ue9ndiz, 3scar Prada-Delgado, Oz Shapira, P Christian Schulze, Pachara Panpunuan, Pal Maurovich-Horvat, Pallav Garg, Paloma Moraga, Pam Singh, Pamela Julian, Pamela Ouyang, Pamela Sigel, Pamela Woodard, Panpan Zhou, Paola Emanuela Poggio, Paola Smanio, Paolo Calabro, Paramjit Jeetley, Pascal Goube, Patricia K Nguyen, Patricia Alarie, Patricia Arakelian, Patricia Arsenault, Patricia Blaise, Patricia Brito, Patricia Cowper, Patricia Endsley, Patricia Mieses, Patrick B Alexander, Patrick Donnelly, Patrick Wilmot, Patrycja Lebioda, Paul C Gordon, Paul Der Mesropian, Paul Galiwango, Paul Hauptman, Paul Kennedy, Paula Beardsley, Paula Garc\ueda-Gonz\ue1lez, Paulo Cury Rezende, Paulo Ricardo Caramori, Pavel S Kozlov, Pedro Canas Silva, Pedro Gabriel Melo Barros E Silva, Pedro P\uedccaro de Oliveira, Pedro Carvalho, Pedro Modas, Pedro Rio, Peeyush Jain, Peiyu He, Peter A McCullough, Peter H Stone, Peter M Pollak, Peter Douglass, Peter Henriksen, Peter OKane, Peter Ong, Philip Jones, Philip Rogal, Philippe G\ue9n\ue9reux, Philippe Menasche, Philippe Rheault, Phoebe Goold, Pierre Gervais, Pierre Michaud, Pilar Calvillo, Ping Chai, Piotr Jakubowski, Piotr Pruszczyk, Piotr Slomka, Piyamitr Sritara, Poay-Huan Loh, Poonam Sonawane, Pouneh Samadi, Pragnesh P Parikh, Prakash Deedwania, Pranav M Patel, Praneeth Polamuri, Pratiksha Sharma, Precilia Vasquez, Preeti Kamath, Prince Thomas, Priyadarshani Arambam, Puja K 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Sajeev Chakanalil Govindan, Saket Girotra, Saleem Kassam, Sallie Canada, Salvador Cruz-Flores, Samaa Mohamed, Samantha Ly, Sameh El Kaffas, Samia Massalha, Sampoornima Setty, Samuel Nwosu, Sandeep Seth, Sandeep Singh, Sander R Niehe, Sandra M Rivest, Sandra S Zier, Sandra Ahoud, Sandy Carr, Sanjay Ganapathi, Sanjay Shetty, Sanjeev Sharma, Santa Jimenez, Santhosh Satheesh, Santiago A Garcia, Sara Fernandez, Sara Karlsson, Sara Salkind, Sara Temiyasathit, Sarah Medina Rodriguez, Sarah Beaudry, Sarah Hadjih, Sarah Williams, Sarah Zahrani, Sarju Ralhan, Sasa Hinic, Sasko Kedev, Satinder Singh, Satoshi Yasuda, Satvic Cholenahally Manjunath, Sau Lee, Scott M Kaczkowski, Scott Kinlay, Sean W Hayes, Sebastian Sobczak, Senait Asier, Sergey A Sayganov, Seth I Sokol, Shaheen Pandie, Shaiful Azmi Yahaya, Shamir Mehta, Shao-Ping Nie, Sharad Chandra, Sharder Islam, Sharon Tai, Sheetal Rupesh Karwa, Sheri Ussery, Sheromani Bajaj, Sherron C Crook, Shigeyuki Nishimura, Shintaro Nakano, Shirin Heydari, 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Suellen Hosino, Sukie Desire, Sukit Yamwong, Suku T Thambar, Sulagna Mookherjee, Suman Singh, Sundeep Mishra, Sunil Kumar Verma, Supap Kulthawong, Supatchara Khwakhong, Surendra Naik, Suresh Babu, Surin Woragidpoonpol, Suryaprakash Narayanappa, Susan Derbyshire, Susan Gent, Susan Mathus, Susan Milbrandt, Susan Moore, Susan Regan, Susan Stinson, Susan Webber, Susana Silva, Susanna Stevens, Susanne Gruensfelder, Suthara Aramcharoen, Suvarna Kolhe, Suzana Tavares, Suzanne Arnold, Suzanne Welsh, Svetlana Apostolovic, Swapna Kunhunny, Ta-Chuan Hung, Taissa Zappernick, Tali Sharir, Talita Silva, Tamara Colai\ue1covo Soares, Tapan Umesh Pillay, Tarun K Mittal, Tatiana Trifonova, Tauane Bello Duarte, Tauqir Huk, T\ue9odora Dutoiu, Terrance Chua, Terry Weyand, Thabitha Charles, Theodoros Kofidis, Theresa McCreary, Thierry Lefevre, Thippeekaa Arumairajah, Thitipong Tepsuwan, Thomas J Mulhearn, Thomas M Meyer, Thomas P Rocco, Thomas R Downes, Thomas Crain, Thomas Haldis, Thomas Mathew, Thomas 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Ziliang Bai, Zixiang Yu, Zohra Huda, Zoltan Davidovits
- Jones P.G.
- Mark D.B
- Maron D.J.
- Mavromatis K.
- Mavromichalis S.
- Newman J.D.
- O'Brien S.M.
- Reynolds H.R.
- Rosenberg Y.
- Spertus J.A.
- Stone G.W.
- Weintraub W.S.
- Publication venue
- 'Massachusetts Medical Society'
- Publication date
- 01/01/2020
- Field of study
BACKGROUND In the ISCHEMIA trial, an invasive strategy with angiographic assessment and revascularization did not reduce clinical events among patients with stable ischemic heart disease and moderate or severe ischemia. A secondary objective of the trial was to assess angina-related health status among these patients. METHODS We assessed angina-related symptoms, function, and quality of life with the Seattle Angina Questionnaire (SAQ) at randomization, at months 1.5, 3, and 6, and every 6 months thereafter in participants who had been randomly assigned to an invasive treatment strategy (2295 participants) or a conservative strategy (2322). Mixed-effects cumulative probability models within a Bayesian framework were used to estimate differences between the treatment groups. The primary outcome of this health-status analysis was the SAQ summary score (scores range from 0 to 100, with higher scores indicating better health status). All analyses were performed in the overall population and according to baseline angina frequency. RESULTS At baseline, 35% of patients reported having no angina in the previous month. SAQ summary scores increased in both treatment groups, with increases at 3, 12, and 36 months that were 4.1 points (95% credible interval, 3.2 to 5.0), 4.2 points (95% credible interval, 3.3 to 5.1), and 2.9 points (95% credible interval, 2.2 to 3.7) higher with the invasive strategy than with the conservative strategy. Differences were larger among participants who had more frequent angina at baseline (8.5 vs. 0.1 points at 3 months and 5.3 vs. 1.2 points at 36 months among participants with daily or weekly angina as compared with no angina). CONCLUSIONS In the overall trial population with moderate or severe ischemia, which included 35% of participants without angina at baseline, patients randomly assigned to the invasive strategy had greater improvement in angina-related health status than those assigned to the conservative strategy. The modest mean differences favoring the invasive strategy in the overall group reflected minimal differences among asymptomatic patients and larger differences among patients who had had angina at baseline