Associations between Different Ozone Indicators and Cardiovascular Hospital Admission:A Time-Stratified Case-Crossover Analysis in Guangzhou, China

Epidemiological studies reported that ozone (O3) is associated with cardiovascular diseases. However, only few of these studies examined the impact of multiple O3 indicators on cardiovascular hospital admissions. This study aimed to explore and compare the impacts of different O3 indicators on cardiovascular hospital admissions in Guangzhou, China. Based upon the data on daily cardiovascular hospital admissions, air pollution, and meteorological factors in Guangzhou from 2014 to 2018, a time-stratified case-crossover design model was used to analyze the associations between different O3 indicators and cardiovascular hospital admissions. Moreover, the sensitivities of different age and gender groups were analyzed for the whole year and different seasons (i.e., warm and cold). During the warm season, for the single-pollutant model, the odds ratio (OR) value of cardiovascular hospital admissions was 1.0067 (95% confidence interval (CI): 1.0037, 1.0098) for every IQR increase in MDA8 O3 at a lag of five days. The effect of O3 on people over 60 year was stronger than that on the 15–60 years age group. Females were more sensitive than males to O3 exposure. These results provided valuable references for further scientific research and environmental improvement in Guangzhou. Given that short-term O3 exposure poses a threat to human health, the government should therefore pay attention to prevention and control policies to reduce and eliminate O3 pollution and protect human health.</p

Comparison of the association between different ozone indicators and daily respiratory hospitalization in Guangzhou, China

Background: Epidemiological studies have widely proven the impact of ozone (O3) on respiratory mortality, while only a few studies compared the association between different O3 indicators and health. Methods: This study explores the relationship between daily respiratory hospitalization and multiple ozone indicators in Guangzhou, China, from 2014 to 2018. It uses a time-stratified case–crossover design. Sensitivities of different age and gender groups were analyzed for the whole year, the warm and the cold periods. We compared the results from the single-day lag model and the moving average lag model. Results: The results showed that the maximum daily 8 h average ozone concentration (MDA8 O3) had a significant effect on the daily respiratory hospitalization. This effect was stronger than for the maximum daily 1 h average ozone concentration (MDA1 O3). The results further showed that O3 was positively associated with daily respiratory hospitalization in the warm season, while there was a significantly negative association in the cold season. Specifically, in the warm season, O3 has the most significant effect at lag 4 day, with the odds ratio (OR) equal to 1.0096 [95% confidence intervals (CI): 1.0032, 1.0161]. Moreover, at the lag 5 day, the effect of O3 on the 15–60 age group was less than that on people older than 60 years, with the OR value of 1.0135 (95% CI: 1.0041, 1.0231) for the 60+ age group; women were more sensitive than men to O3 exposure, with an OR value equal to 1.0094 (95% CI: 0.9992, 1.0196) for the female group. Conclusion: These results show that different O3 indicators measure different impacts on respiratory hospitalization admission. Their comparative analysis provided a more comprehensive insight into exploring associations between O3 exposure and respiratory health.</p

Genomic monitoring of SARS-CoV-2 uncovers an Nsp1 deletion variant that modulates type I interferon response

The SARS-CoV-2 virus, the causative agent of COVID-19, is undergoing constant mutation. Here, we utilized an integrative approach combining epidemiology, virus genome sequencing, clinical phenotyping, and experimental validation to locate mutations of clinical importance. We identified 35 recurrent variants, some of which are associated with clinical phenotypes related to severity. One variant, containing a deletion in the Nsp1-coding region (D500-532), was found in more than 20% of our sequenced samples and associates with higher RT-PCR cycle thresholds and lower serum IFN-beta levels of infected patients. Deletion variants in this locus were found in 37 countries worldwide, and viruses isolated from clinical samples or engineered by reverse genetics with related deletions in Nsp1 also induce lower IFN-beta responses in infected Calu-3 cells. Taken together, our virologic surveillance characterizes recurrent genetic diversity and identified mutations in Nsp1 of biological and clinical importance, which collectively may aid molecular diagnostics and drug design.Peer reviewe

Large expert-curated database for benchmarking document similarity detection in biomedical literature search

Document recommendation systems for locating relevant literature have mostly relied on methods developed a decade ago. This is largely due to the lack of a large offline gold-standard benchmark of relevant documents that cover a variety of research fields such that newly developed literature search techniques can be compared, improved and translated into practice. To overcome this bottleneck, we have established the RElevant LIterature SearcH consortium consisting of more than 1500 scientists from 84 countries, who have collectively annotated the relevance of over 180 000 PubMed-listed articles with regard to their respective seed (input) article/s. The majority of annotations were contributed by highly experienced, original authors of the seed articles. The collected data cover 76% of all unique PubMed Medical Subject Headings descriptors. No systematic biases were observed across different experience levels, research fields or time spent on annotations. More importantly, annotations of the same document pairs contributed by different scientists were highly concordant. We further show that the three representative baseline methods used to generate recommended articles for evaluation (Okapi Best Matching 25, Term Frequency-Inverse Document Frequency and PubMed Related Articles) had similar overall performances. Additionally, we found that these methods each tend to produce distinct collections of recommended articles, suggesting that a hybrid method may be required to completely capture all relevant articles. The established database server located at https://relishdb.ict.griffith.edu.au is freely available for the downloading of annotation data and the blind testing of new methods. We expect that this benchmark will be useful for stimulating the development of new powerful techniques for title and title/abstract-based search engines for relevant articles in biomedical research.Peer reviewe

Dynamics Response of Rail Vehicle Induced by Incorporating Electric-Dominated Transmission Component

As an important component of train speed regulation, traction transmission system is the power source and the main transmission component of traction force. Its dynamic characteristics can affect the dynamic performance of vehicle system to a certain extent. With the rapid development of rail train transportation in China, the running speed of the train continues to improve, the dynamic characteristics of the vehicle is becoming more complex, and the influence of the electrical part of the traction transmission system gradually appears. The motor and gearbox are crucial components of the train power bogie to complete the conversion and transmission of electric energy to mechanical energy, with their dynamic characteristics are most directly affected by the electrical characteristics of the traction system. In this work, a vehicle electro-mechanical coupling mathematical model based on multi-body dynamics was established by explicitly incorporating the electric-induced traction into the transmission system, to study the influence of traction system vibration on vehicle dynamics. The dynamics responses of the lateral and longitudinal vibration on vehicle motor and gearbox were quantitatively analysed from the traction drive system. Compared with the line test, it was observed that 12-times of the fundamental frequency of the rotor has a great influence on the motor and gearbox

Development of main functional modules for MVB and its application in rail transit

In this work, multi-function vehicle bus (MVB) controller-based Field Programmable Gate Array (FPGA) and MVB manager based on the real-time multitasking operating system were explored and developed. The function of the MVB controller data link layer was realised by using FPGA. The embedded real-time multitasking operating system uCOS-II was applied to the development of MVB manager’s processing data, device state management, message data and bus management function. The network consistency test was performed to validate data communication of MVB link layer control protocol and the management function of MVB manager; the equipment was shown to be compatible with each other and met the requirements of IEC61375-1

The relationship between heat flow and seismicity in global tectonically active zones

This study aims to analyze the complex relationship between heat flow and seismicity in tectonically active zones worldwide. The problem was quantitatively analyzed by using a geographic detector method, which is well suited for analyzing nonlinear relationships in geography. Moreover, β-value that describes the frequency-magnitude distribution is used to represent the seismicity. The results showed that heat flow (HF) = 84 mW/m2 is a critical point for the relevant mechanisms of heat flow with seismicity in these zones. When HF 84 mW/m2, the heat flow correlates positively with the β-value, with a correlation degree of 0.463. Within this interval, the increased heat flow decreases the viscosity of the rock plate and then reduces the stress. Lower stress would correspond to a smaller earthquake and then a higher β-value. Therefore, high heat flow values correspond to high β-values. This research would be conducive to understand the geologic activity and be helpful to determine the accuracy and timeliness of seismic hazard assessment

Visualized analysis of developing trends and hot topics in natural disaster research

<div><p>This study visualized and analyzed the developing trends and hot topics in natural disaster research. 19694 natural disaster-related articles (January 1900 to June 2015) are indexed in the Web of Science database. The first step in this study is using complex networks to visualize and analyze these articles. CiteSpace and Gephi were employed to generate a countries collaboration network and a disciplines collaboration network, and then attached hot topics to countries and disciplines, respectively. The results show that USA, China, and Italy are the three major contributors to natural disaster research. “Prediction model”, “social vulnerability”, and “landslide inventory map” are three hot topics in recent years. They have attracted attention not only from large countries like China but also from small countries like Panama and Turkey. Comparing two hybrid networks provides details of natural disaster research. Scientists from USA and China use image data to research earthquakes. Indonesia and Germany collaboratively study tsunamis in the Indian Ocean. However, Indonesian studies focus on modeling and simulations, while German research focuses on early warning technology. This study also introduces an activity index (AI) and an attractive index (AAI) to generate time evolution trajectories of some major countries from 2000 to 2013 and evaluate their trends and performance. Four patterns of evolution are visible during this 14-year period. China and India show steadily rising contributions and impacts, USA and England show relatively decreasing research efforts and impacts, Japan and Australia show fluctuating activities and stable attraction, and Spain and Germany show fluctuating activities and increasing impacts.</p></div

Relational chart of AI and AAI from 2000 to 2013 for 8 countries/regions, China, India, the U.S., England, Japan, Australia, Spain, and Germany.

<p>The reference line <i>x</i> = <i>y</i> represents the balanced status of AI and AAI of a country/reigon’s natural diaster research.</p