Sum-Rate Optimization for RIS-Aided Multiuser Communications with Movable Antenna

Reconfigurable intelligent surface (RIS) is known as a promising technology to improve the performance of wireless communication networks, which has been extensively studied. Movable antenna (MA) is a novel technology that fully exploits the antenna position for enhancing the channel capacity. In this paper, we propose a new RIS-aided multiuser communication system with MAs. The sum-rate is maximized by jointly optimizing the beamforming, the reflection coefficient (RC) values of RIS and the positions of MAs. A fractional programming-based iterative algorithm is proposed to solve the formulated non-convex problem, considering three assumptions for the RIS. Numerical results are presented to verify the effectiveness of the proposed algorithm and the superiority of the proposed MA-based system in terms of sum-rate.Comment: 5 page

Near-Field Communications: A Tutorial Review

Extremely large-scale antenna arrays, tremendously high frequencies, and new types of antennas are three clear trends in multi-antenna technology for supporting the sixth-generation (6G) networks. To properly account for the new characteristics introduced by these three trends in communication system design, the near-field spherical-wave propagation model needs to be used, which differs from the classical far-field planar-wave one. As such, near-field communication (NFC) will become essential in 6G networks. In this tutorial, we cover three key aspects of NFC. 1) Channel Modelling: We commence by reviewing near-field spherical-wave-based channel models for spatially-discrete (SPD) antennas. Then, uniform spherical wave (USW) and non-uniform spherical wave (NUSW) models are discussed. Subsequently, we introduce a general near-field channel model for SPD antennas and a Green's function-based channel model for continuous-aperture (CAP) antennas. 2) Beamfocusing and Antenna Architectures: We highlight the properties of near-field beamfocusing and discuss NFC antenna architectures for both SPD and CAP antennas. Moreover, the basic principles of near-field beam training are introduced. 3) Performance Analysis: Finally, we provide a comprehensive performance analysis framework for NFC. For near-field line-of-sight channels, the received signal-to-noise ratio and power-scaling law are derived. For statistical near-field multipath channels, a general analytical framework is proposed, based on which analytical expression for the outage probability, ergodic channel capacity, and ergodic mutual information are derived. Finally, for each aspect, the topics for future research are discussed.Comment: 45 pages, 35 figures; submitted to possible IEEE journa

Near-Field Communications: A Comprehensive Survey

Multiple-antenna technologies are evolving towards large-scale aperture sizes, extremely high frequencies, and innovative antenna types. This evolution is giving rise to the emergence of near-field communications (NFC) in future wireless systems. Considerable attention has been directed towards this cutting-edge technology due to its potential to enhance the capacity of wireless networks by introducing increased spatial degrees of freedom (DoFs) in the range domain. Within this context, a comprehensive review of the state of the art on NFC is presented, with a specific focus on its 1) fundamental operating principles, 2) channel modeling, 3) performance analysis, 4) signal processing, and 5) integration with other emerging technologies. Specifically, 1) the basic principles of NFC are characterized from both physics and communications perspectives, unveiling its unique properties in contrast to far-field communications. 2) Based on these principles, deterministic and stochastic near-field channel models are investigated for spatially-discrete (SPD) and continuous-aperture (CAP) antenna arrays. 3) Rooted in these models, existing contributions on near-field performance analysis are reviewed in terms of DoFs/effective DoFs (EDoFs), power scaling law, and transmission rate. 4) Existing signal processing techniques for NFC are systematically surveyed, encompassing channel estimation, beamforming design, and low-complexity beam training. 5) Major issues and research opportunities associated with the integration of NFC and other emerging technologies are identified to facilitate NFC applications in next-generation networks. Promising directions are highlighted throughout the paper to inspire future research endeavors in the realm of NFC.Comment: 56 pages, 23figures; submit for possible journa

Sclerostin decreases in regular swimmers after ice swimming and is associated with meteorin-like protein serum levels

Introduction: Cold and exercise are two important stimuli affecting the secretion of osteokines and adipomyokines, which often occur simultaneously. However, few studies have investigated the changes in osteokines and adipomyokines induced by exercise during severe cold and their corresponding associations. Therefore, this study aimed to investigate the changes in sclerostin and meteorin-like (metrnl) protein before and after cold exercise (ice swimming [IS]) and observe their correlation.Methods: For this, 56 daily ice swimmers’ data were included in this study. Serum sclerostin and metrnl were measured 30 min before IS and 30 min after. The fat mass, visceral fat area, fat-free mass, skeletal muscle mass, lumbar spine, and femoral neck bone mineral density of the ice swimmers were measured.Results: After IS, sclerostin exhibited significant decreases, whereas metrnl showed no significant change. In addition, the baseline level of sclerostin and the decrease in sclerostin were positively correlated with serum metrnl after adjusting for age, gender, and body composition indicators.Discussion: IS caused a significant decrease in sclerostin but did not affect metrnl. Furthermore, the associations between sclerostin and metrnl suggested a correlation between osteokines and adipomyokines; this encourages future exploration of the interconnection between bone, muscle, and fat, which will be beneficial for identifying potential common therapeutic targets for diseases such as osteoporosis, sarcopenia, and obesity

Identification of a novel ANK1 gene variant c.1504-9G>A and its mechanism of intron retention in hereditary spherocytosis

Objective: The objective of this study was to pinpoint pathogenic genes and assess the mutagenic pathogenicity in two pediatric patients with hereditary spherocytosis.Methods: We utilized whole-exome sequencing (WES) for individual analysis (case 1) and family-based trio analysis (case 2). The significance of the intronic mutation was validated through a Minigene splicing assay and supported by subsequent in vitro experiments.Results: Both probands received a diagnosis of hereditary spherocytosis. WES identified a novel ANK1 c.1504-9G>A mutation in both patients, causing the retention of seven nucleotides at the 5′ end of intron 13, as substantiated by the Minigene assay. This variant results in a premature stop codon and the production of a truncated protein. In vitro studies indicated a reduced expression of the ANK1 gene.Conclusion: The novel ANK1 c.1504-9G>A variant is established as the causative factor for hereditary spherocytosis, with the c.1504-9G site functioning as a splicing receptor

CoolMPS: evaluation of antibody labeling based massively parallel non-coding RNA sequencing

Results of massive parallel sequencing-by-synthesis vary depending on the sequencing approach. CoolMPS™ is a new sequencing chemistry that incorporates bases by labeled antibodies. To evaluate the performance, we sequenced 240 human non-coding RNA samples (dementia patients and controls) with and without CoolMPS. The Q30 value as indicator of the per base sequencing quality increased from 91.8 to 94%. The higher quality was reached across the whole read length. Likewise, the percentage of reads mapping to the human genome increased from 84.9 to 86.2%. For both technologies, we computed similar distributions between different RNA classes (miRNA, piRNA, tRNA, snoRNA and yRNA) and within the classes. While standard sequencing-by-synthesis allowed to recover more annotated miRNAs, CoolMPS yielded more novel miRNAs. The correlation between the two methods was 0.97. Evaluating the diagnostic performance, we observed lower minimal P-values for CoolMPS (adjusted P-value of 0.0006 versus 0.0004) and larger effect sizes (Cohen's d of 0.878 versus 0.9). Validating 19 miRNAs resulted in a correlation of 0.852 between CoolMPS and reverse transcriptase-quantitative polymerase chain reaction. Comparison to data generated with Illumina technology confirmed a known shift in the overall RNA composition. With CoolMPS we evaluated a novel sequencing-by-synthesis technology showing high performance for the analysis of non-coding RNAs

Randomized trials of artemisinin-piperaquine, dihydroartemisinin-piperaquine phosphate and artemether-lumefantrine for the treatment of multi-drug resistant falciparum malaria in Cambodia-Thailand border area

<p>Abstract</p> <p>Background</p> <p>Drug resistance of falciparum malaria is a global problem. Sulphadoxine/pyrimethamine-resistant and mefloquine-resistant strains of falciparum malaria have spread in Southeast Asia at lightning speed in 1980s-1990s, and the Cambodia-Thailand border is one of the malaria epidemic areas with the most severe forms of multi-drug resistant falciparum malaria.</p> <p>Methods</p> <p>Artemisinin-piperaquine (AP), dihydroartemisinin-piperaquine phosphate (DHP) and artemether-lumefantrine (AL) were used to treat 110, 55 and 55 uncomplicated malaria patients, respectively. The total dosage for adults is 1,750 mg (four tablets, twice over 24 hours) of AP, 2,880 mg (eight tablets, four times over two days) of DHP, and 3,360 mg (24 tablets, six times over three days) of AL. The 28-day cure rate, parasite clearance time, fever clearance time, and drug tolerance of patients to the three drugs were compared. All of the above methods were consistent with the current national guidelines.</p> <p>Results</p> <p>The mean parasite clearance time was similar in all three groups (66.7 ± 21.9 hrs, 65.6 ± 27.3 hrs, 65.3 ± 22.5 hrs in AP, DHP and AL groups, respectively), and there was no remarkable difference between them; the fever clearance time was also similar (31.6 ± 17.7 hrs, 34.6 ± 21.8 hrs and 36.9 ± 15.4 hrs, respectively). After following up for 28-days, the cure rate was 95.1%(97/102), 98.2%(54/55) and 82.4%(42/51); and the recrudescence cases was 4.9%(5/102), 1.8%(1/55) and 17.6%(9/51), respectively. Therefore, the statistical data showed that 28-day cure rate in AP and DHP groups was superior to AL group obviously.</p> <p>The patients had good tolerance to all the three drugs, and some side effects (anoxia, nausea, vomiting, headache and dizziness) could be found in every group and they were self-limited; patients in control groups also had good tolerance to DHP and AL, there was no remarkable difference in the three groups.</p> <p>Conclusions</p> <p>AP, DHP and AL all remained efficacious treatments for the treatment of falciparum malaria in Cambodia-Thailand border area. However, in this particular setting, the AP regimen turned out to be favourable in terms of efficacy and effectiveness, simplicity of administration, cost and compliance.</p> <p>Trial Registration</p> <p>The trial was registered at <it>Chinese Clinical Trial Register </it>under identifier 2005L01041.</p

Large expert-curated database for benchmarking document similarity detection in biomedical literature search

Document recommendation systems for locating relevant literature have mostly relied on methods developed a decade ago. This is largely due to the lack of a large offline gold-standard benchmark of relevant documents that cover a variety of research fields such that newly developed literature search techniques can be compared, improved and translated into practice. To overcome this bottleneck, we have established the RElevant LIterature SearcH consortium consisting of more than 1500 scientists from 84 countries, who have collectively annotated the relevance of over 180 000 PubMed-listed articles with regard to their respective seed (input) article/s. The majority of annotations were contributed by highly experienced, original authors of the seed articles. The collected data cover 76% of all unique PubMed Medical Subject Headings descriptors. No systematic biases were observed across different experience levels, research fields or time spent on annotations. More importantly, annotations of the same document pairs contributed by different scientists were highly concordant. We further show that the three representative baseline methods used to generate recommended articles for evaluation (Okapi Best Matching 25, Term Frequency-Inverse Document Frequency and PubMed Related Articles) had similar overall performances. Additionally, we found that these methods each tend to produce distinct collections of recommended articles, suggesting that a hybrid method may be required to completely capture all relevant articles. The established database server located at https://relishdb.ict.griffith.edu.au is freely available for the downloading of annotation data and the blind testing of new methods. We expect that this benchmark will be useful for stimulating the development of new powerful techniques for title and title/abstract-based search engines for relevant articles in biomedical research.Peer reviewe