Mechanically coupled laminates with balanced plain weave

Definitive listings of laminate stacking sequences are derived for balanced plain weave laminated materials, assuming each layer is composed of the same material with constant thickness throughout and that standard ply angle orientations 0, 90, and ±45° are adopted; consistent with industrial design practice. A single layer of balanced plain weave material is shown to be immune to thermal distortion following a standard high temperature manufacturing process, which implies that all laminates constructed of this material possess what is commonly referred to as the hygro-thermally curvature-stable or warp-free condition, irrespective of the individual ply orientations used or the laminate stacking sequence definition. A single uncoupled parent laminate class is shown to contain sub-groups with extensionally isotropic and fully isotropic properties that are invariant with off-axis orientation of the principal material axes with respect to the system or structural axes. By contrast a single mechanically coupled parent laminate class is shown to give rise to seven unique forms of coupled laminate through judicious off-axis orientation. Invariant off-axis properties are also identified in coupled laminate designs. Finally, example calculations, abridged stacking sequence listings and design data are presented

POISSON project - II - A multi-wavelength spectroscopic and photometric survey of young protostars in L 1641

Characterising stellar and circumstellar properties of embedded young stellar objects (YSOs) is mandatory for understanding the early stages of the stellar evolution. This task requires the combination of both spectroscopy and photometry, covering the widest possible wavelength range, to disentangle the various protostellar components and activities. As part of the POISSON project, we present a multi-wavelength spectroscopic and photometric investigation of embedded YSOs in L1641, aimed to derive the stellar parameters and evolutionary stages and to infer their accretion properties. Our database includes low-resolution optical-IR spectra from the NTT and Spitzer (0.6-40 um) and photometric data covering a spectral range from 0.4 to 1100 um, which allow us to construct the YSOs spectral energy distributions (SEDs) and to infer the main stellar parameters. The SED analysis allows us to group our 27 YSOs into nine Class I, eleven Flat, and seven Class II objects. However, on the basis of the derived stellar properties, only six Class I YSOs have an age of ~10^5 yr, while the others are older 5x10^5-10^6 yr), and, among the Flat sources, three out of eleven are more evolved objects (5x10^6-10^7 yr), indicating that geometrical effects can significantly modify the SED shapes. Inferred mass accretion rates (Macc) show a wide range of values (3.6x10^-9 to 1.2x10^-5 M_sun yr^-1), which reflects the age spread observed in our sample. Average values of mass accretion rates, extinction, and spectral indices decrease with the YSO class. The youngest YSOs have the highest Macc, whereas the oldest YSOs do not show any detectable jet activity in either images and spectra. We also observe a clear correlation among the YSO Macc, M*, and age, consistent with mass accretion evolution in viscous disc models.Comment: 61 pages, 16 figures; A&A in pres

AKARI's infrared view on nearby stars : Using AKARI Infrared Camera All-Sky Survey, 2MASS, and Hipparcos catalog

--Results-- We found that the (B-V) v.s. (V-S9W) color-color diagram is useful to identify the stars with infrared excess emerged from circumstellar envelopes/disks. Be stars with infrared excess are well separated from other types of stars in this diagram. Whereas (J-L18W) v.s. (S9W-L18W) diagram is a powerful tool to classify several object-types. Carbon-rich asymptotic giant branch (AGB) stars and OH/IR stars form distinct sequences in this color-color diagram. Young stellar objects (YSOs), pre-main sequence (PMS) stars, post-AGB stars and planetary nebulae (PNe) have largest mid-infrared color-excess, and can be identified in infrared catalog. Finally, we plot L18W v.s. (S9W-L18W) color-magnitude diagram, using the AKARI data together with Hipparcos parallaxes. This diagram can be used to identify low-mass YSOs, as well as AGB stars. We found that this diagram is comparable to the [24] vs ([8.0]-[24]) diagram of Large Magellanic Cloud sources using the Spitzer Space Telescope data. Our understanding of Galactic objects will be used to interpret color-magnitude diagram of stellar populations in nearby galaxies which Spitzer Space Telescope has observed. --Conclusions-- Our study of the AKARI color-color and color-magnitude will be used to explore properties of unknown objects in future. In addition, our analysis highlights a future key project to understand stellar evolution with circumstellar envelope, once the forthcoming astronometrical data with GAIA are available.Comment: 14 pages, 11 figures, accepted for publication in A&A. High resolution version is available at: http://www.ir.isas.jaxa.jp/%7Eyita/allsky20100302.pdf (26Mb

Global burden of 369 diseases and injuries in 204 countries and territories, 1990–2019: a systematic analysis for the Global Burden of Disease Study 2019

Background: In an era of shifting global agendas and expanded emphasis on non-communicable diseases and injuries along with communicable diseases, sound evidence on trends by cause at the national level is essential. The Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) provides a systematic scientific assessment of published, publicly available, and contributed data on incidence, prevalence, and mortality for a mutually exclusive and collectively exhaustive list of diseases and injuries. Methods: GBD estimates incidence, prevalence, mortality, years of life lost (YLLs), years lived with disability (YLDs), and disability-adjusted life-years (DALYs) due to 369 diseases and injuries, for two sexes, and for 204 countries and territories. Input data were extracted from censuses, household surveys, civil registration and vital statistics, disease registries, health service use, air pollution monitors, satellite imaging, disease notifications, and other sources. Cause-specific death rates and cause fractions were calculated using the Cause of Death Ensemble model and spatiotemporal Gaussian process regression. Cause-specific deaths were adjusted to match the total all-cause deaths calculated as part of the GBD population, fertility, and mortality estimates. Deaths were multiplied by standard life expectancy at each age to calculate YLLs. A Bayesian meta-regression modelling tool, DisMod-MR 2.1, was used to ensure consistency between incidence, prevalence, remission, excess mortality, and cause-specific mortality for most causes. Prevalence estimates were multiplied by disability weights for mutually exclusive sequelae of diseases and injuries to calculate YLDs. We considered results in the context of the Socio-demographic Index (SDI), a composite indicator of income per capita, years of schooling, and fertility rate in females younger than 25 years. Uncertainty intervals (UIs) were generated for every metric using the 25th and 975th ordered 1000 draw values of the posterior distribution. Findings: Global health has steadily improved over the past 30 years as measured by age-standardised DALY rates. After taking into account population growth and ageing, the absolute number of DALYs has remained stable. Since 2010, the pace of decline in global age-standardised DALY rates has accelerated in age groups younger than 50 years compared with the 1990–2010 time period, with the greatest annualised rate of decline occurring in the 0–9-year age group. Six infectious diseases were among the top ten causes of DALYs in children younger than 10 years in 2019: lower respiratory infections (ranked second), diarrhoeal diseases (third), malaria (fifth), meningitis (sixth), whooping cough (ninth), and sexually transmitted infections (which, in this age group, is fully accounted for by congenital syphilis; ranked tenth). In adolescents aged 10–24 years, three injury causes were among the top causes of DALYs: road injuries (ranked first), self-harm (third), and interpersonal violence (fifth). Five of the causes that were in the top ten for ages 10–24 years were also in the top ten in the 25–49-year age group: road injuries (ranked first), HIV/AIDS (second), low back pain (fourth), headache disorders (fifth), and depressive disorders (sixth). In 2019, ischaemic heart disease and stroke were the top-ranked causes of DALYs in both the 50–74-year and 75-years-and-older age groups. Since 1990, there has been a marked shift towards a greater proportion of burden due to YLDs from non-communicable diseases and injuries. In 2019, there were 11 countries where non-communicable disease and injury YLDs constituted more than half of all disease burden. Decreases in age-standardised DALY rates have accelerated over the past decade in countries at the lower end of the SDI range, while improvements have started to stagnate or even reverse in countries with higher SDI. Interpretation: As disability becomes an increasingly large component of disease burden and a larger component of health expenditure, greater research and developm nt investment is needed to identify new, more effective intervention strategies. With a rapidly ageing global population, the demands on health services to deal with disabling outcomes, which increase with age, will require policy makers to anticipate these changes. The mix of universal and more geographically specific influences on health reinforces the need for regular reporting on population health in detail and by underlying cause to help decision makers to identify success stories of disease control to emulate, as well as opportunities to improve. Funding: Bill & Melinda Gates Foundation. © 2020 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 licens

Use of Citrated Whole Blood for Point-of-Care Viscoelastic Coagulation Testing in Dogs

Background: A new, portable bedside coagulation monitor (VCM Vet) has provided a user-friendly, cartridge-based method to perform viscoelastic testing. However, the use of native whole blood limits the time to analyze the sample to minutes. The objective of this study is to assess whether citrated whole blood can be utilized with the cartridge-based system and whether the results are comparable to those of native whole blood. A secondary objective is to assess the viability of citrated whole blood results after up to 4 hours of resting. Methods: The study population consisted of 10 healthy mixed breed dogs. Whole blood samples were collected jugular venipuncture. Blood was immediately transferred to the VCM test cartridge for native whole blood control group analysis per the manufacturer\u27s instructions, and the remainder was used to fill two 3.2% sodium citrate vacutainer tubes. Test group analysis was performed on samples from each tube concurrently after a rest period of 30 min (baseline), 2 h, and 4 h. Citrated whole blood samples were recalcified for analysis immediately prior to introduction into the test cartridge. Data was recorded for all reported parameters. Results from the citrate groups were compared to the control group and to the citrated baseline to assess for differences. Overall results were compared using mixed ANOVA models. Where found, specific differences were evaluated using Tukey\u27s test. Within-sample variation was investigated and reported as median (range). A \u3c 0.05 was considered significant. Results: Samples were obtained for a total of 10 control runs and 20 citrated whole blood runs. Comparison of controls to the citrated test groups revealed significant differences in CT ( \u3c 0.001) and MCF ( \u3c 0.002). There were no significant differences between test groups compared to citrated baselines for any parameter. Selected median coefficients of variation were 6.8% (0-68.8%) for CT, 2.4% (0-19.46%) for alpha angle, 3.2% (0-27.4%) for MCF, and 0% (0-16.3%) for 45-min LY45. Conclusion: Citrated whole blood samples can be used with the VCM Vet device; however, new reference intervals for use with citrated whole blood will be required. Results using citrated whole blood samples are not significantly different from baseline after up to 4 h of resting

Structural characterisation of galactoglucomannan secreted by suspension-cultured cells of Nicotiana plumbaginifolia

Galactoglucomannan (GGM) from cultures of Nicotiana plumbaginifolia has Man:Glc:Gal:Ara:Xyl in 1.0:1.1:1.0:0.1:0.04 ratio. Linkage analysis contained 4- and 4,6-Manp, 4-Glcp, terminal Galp and 2-Galp, small amounts and terminal Arap and terminal Xylp, and similar to 0.03 mol acetyl per mol of glucosyl residue. Treatment with alpha- and beta-D-galactosidases showed that the majority of the side-chains were either single Galp-alpha-(1 --> residues or the disaccharide Galp-beta-(1 --> 2)-Galp-alpha-(1 --> linked to O-6 of the 4-Manp residues of the glucomannan backbone. Analysis of the oligosaccharides generated by endo-(1 --> 4)-beta-mannanase digestion confirmed that the GGM comprises a backbone of predominantly alternating --> 4)-D-Manp-beta-(1 --> and --> Lt)-D-Glcp-beta-(1 --> branched at O-6 of 65% of the 4-Manp residues. The major oligosaccharide identified was D-Glcp-beta-(1 --> 4)-[D-Galp-beta-(1 --> 2)-D-Galp-alpha-(1 --> 6)]-D-Manp-beta-(1 --> 4)-D-Glcp-beta-(I --> 4)-[D-Galp-alpha-(1 --> 6)]-D-Manp-beta-(1 --> (27%), and most of the other oligosaccharides produced in significant quantities were based on this structure. (C) 1997 Elsevier Science Ltd