Reviews

The following publications have been reviewed by the mentioned authors;A Compendium of Craft Books, reviewed by John EgglestonDesign and Designing by I. Burden, J. Morrison and J. Twyford, reviewed by Jeff HardmanThe Establishment and Management of Wildflower Meadows by the Nature Conservancy Council, reviewed by Derek WellsTelephone Boxes by Gavin Stamp, reviewed by John EgglestonShop Fronts by Alan Powers, reviewed by John EgglestonTroughs & Drinking Fountains by Philip Davies, reviewed by John EgglestonSIMCAD Computer Aided Design by OWL Micro Systems, reviewed by Marshall HughesTechnical Drawing by Susan Peach, reviewed by Keith Vicker

Reviews

The following publications have been reviewed by the mentioned authors;An Italic Calligraphy Handbook by Carolyn Knudsen Adams, reviewed by John LancasterDesign and British Industry by Richard Stewart, reviewed by John H. CarswellDesign Graphics by David Fair and Marilyn Kenny, reviewed by D. R. JonesGCSE Craft, Design and Technology by Richard Kimbell, John Plater and Tristram Shepard, reviewed by D. R. JonesProblem Solving in Science and Technology by David Rowlands, reviewed by Peter C. MillrayTechnical Drawing, An Usborne Guide by Susan Peach, reviewed by Keith VickersTVEI and Secondary Education: a critical appraisal by Denis Gleeson, reviewed by Martin MersonWorking in Design by the Careers and Occupational Information Centre, reviewed by S. J. Lodg

Harry I was?!

This is a fictional history of various members of the Smith family interspersed with true facts about United States historical events. It includes true facts about South Carolina Medal of Honor recipients

Inspection time and general speed of processing

Recent research suggests that the relationship between inspection time (IT) and psychometric intelligence arises because IT is a measure of general speed of processing (Gs). However, hierarchical models of intelligence propose several distinct speed of processing factors; this study examines IT in relation to these multiple speed factors. Participants (N=102) completed tests of speed of processing yielding 18 measures. Factor analysis revealed a second order general speed factor (Gs) and four group factors: perceptual speed, visualisation speed, decision time and movement time. IT correlated with a visualisation speed factor (r=0.36) and with a perceptual speed factor (r=0.28). However, the correlation between IT and perceptual speed was near-zero when the correlation with visualisation speed was partialled out. These findings are consistent with the notion that IT is a measure of Gs but suggest that IT most directly measures speed of visualisation processes. These results are also congruent with research on the psychophysics of IT.Tess A. O’Connor and Nicholas R. Burnshttp://www.elsevier.com/wps/find/journaldescription.cws_home/603/description#descriptio

The Health Informatics Trial Enhancement Project (HITE): Using routinely collected primary care data to identify potential participants for a depression trial

<p>Abstract</p> <p>Background</p> <p>Recruitment to clinical trials can be challenging. We identified anonymous potential participants to an existing pragmatic randomised controlled depression trial to assess the feasibility of using routinely collected data to identify potential trial participants. We discuss the strengths and limitations of this approach, assess its potential value, report challenges and ethical issues encountered.</p> <p>Methods</p> <p>Swansea University's Health Information Research Unit's Secure Anonymised Information Linkage (SAIL) database of routinely collected health records was interrogated, using Structured Query Language (SQL). Read codes were used to create an algorithm of inclusion/exclusion criteria with which to identify suitable anonymous participants. Two independent clinicians rated the eligibility of the potential participants' identified. Inter-rater reliability was assessed using the kappa statistic and inter-class correlation.</p> <p>Results</p> <p>The study population (N = 37263) comprised all adults registered at five general practices in Swansea UK. Using the algorithm 867 anonymous potential participants were identified. The sensitivity and specificity results > 0.9 suggested a high degree of accuracy from the algorithm. The inter-rater reliability results indicated strong agreement between the confirming raters. The Intra Class Correlation Coefficient (Cronbach's Alpha) > 0.9, suggested excellent agreement and Kappa coefficient > 0.8; almost perfect agreement.</p> <p>Conclusions</p> <p>This proof of concept study showed that routinely collected primary care data can be used to identify potential participants for a pragmatic randomised controlled trial of folate augmentation of antidepressant therapy for the treatment of depression. Further work will be needed to assess generalisability to other conditions and settings and the inclusion of this approach to support Electronic Enhanced Recruitment (EER).</p

Keeping an eye on noisy movements: On different approaches to perceptual-motor skill research and training

Contemporary theorising on the complementary nature of perception and action in expert performance has led to the emergence of different emphases in studying movement coordination and gaze behaviour. On the one hand, coordination research has examined the role that variability plays in movement control, evidencing that variability facilitates individualised adaptations during both learning and performance. On the other hand, and at odds with this principle, the majority of gaze behaviour studies have tended to average data over participants and trials, proposing the importance of universal 'optimal' gaze patterns in a given task, for all performers, irrespective of stage of learning. In this article, new lines of inquiry are considered with the aim of reconciling these two distinct approaches. The role that inter- and intra-individual variability may play in gaze behaviours is considered, before suggesting directions for future research

Compartir los datos de investigación en ciencia: introducción al data sharing

The emergence in the scientific community of an initiative known as data sharing, consisting of sharing research data among researchers and aiming to maximize efforts and resources, is analysed. First, the concept of research data and the related technical difficulties depending on the discipline are reviewed. We also examine the motivations, origins and growth of this movement, which has had an important impact on the scientific community’s behaviour through the creation of reposi- tories and data banks, raising both technical and social challenges. Then we discuss leading funding agencies’ initiatives and scientific journals’ editorial policies promoting these practices. Finally, we examine the impact these major changes in researchers’ habits have for librarians, including the emergence of new professional profiles

A multi-targeted approach to suppress tumor-promoting inflammation

Cancers harbor significant genetic heterogeneity and patterns of relapse following many therapies are due to evolved resistance to treatment. While efforts have been made to combine targeted therapies, significant levels of toxicity have stymied efforts to effectively treat cancer with multi-drug combinations using currently approved therapeutics. We discuss the relationship between tumor-promoting inflammation and cancer as part of a larger effort to develop a broad-spectrum therapeutic approach aimed at a wide range of targets to address this heterogeneity. Specifically, macrophage migration inhibitory factor, cyclooxygenase-2, transcription factor nuclear factor-κB, tumor necrosis factor alpha, inducible nitric oxide synthase, protein kinase B, and CXC chemokines are reviewed as important antiinflammatory targets while curcumin, resveratrol, epigallocatechin gallate, genistein, lycopene, and anthocyanins are reviewed as low-cost, low toxicity means by which these targets might all be reached simultaneously. Future translational work will need to assess the resulting synergies of rationally designed antiinflammatory mixtures (employing low-toxicity constituents), and then combine this with similar approaches targeting the most important pathways across the range of cancer hallmark phenotypes

Effects of antiplatelet therapy on stroke risk by brain imaging features of intracerebral haemorrhage and cerebral small vessel diseases: subgroup analyses of the RESTART randomised, open-label trial

Background Findings from the RESTART trial suggest that starting antiplatelet therapy might reduce the risk of recurrent symptomatic intracerebral haemorrhage compared with avoiding antiplatelet therapy. Brain imaging features of intracerebral haemorrhage and cerebral small vessel diseases (such as cerebral microbleeds) are associated with greater risks of recurrent intracerebral haemorrhage. We did subgroup analyses of the RESTART trial to explore whether these brain imaging features modify the effects of antiplatelet therapy

Glutamate Slows Axonal Transport of Neurofilaments in Transfected Neurons

Neurofilaments are transported through axons by slow axonal transport. Abnormal accumulations of neurofilaments are seen in several neurodegenerative diseases, and this suggests that neurofilament transport is defective. Excitotoxic mechanisms involving glutamate are believed to be part of the pathogenic process in some neurodegenerative diseases, but there is currently little evidence to link glutamate with neurofilament transport. We have used a novel technique involving transfection of the green fluorescent protein–tagged neurofilament middle chain to measure neurofilament transport in cultured neurons. Treatment of the cells with glutamate induces a slowing of neurofilament transport. Phosphorylation of the side-arm domains of neurofilaments has been associated with a slowing of neurofilament transport, and we show that glutamate causes increased phosphorylation of these domains in cell bodies. We also show that glutamate activates members of the mitogen-activated protein kinase family, and that these kinases will phosphorylate neurofilament side-arm domains. These results provide a molecular framework to link glutamate excitotoxicity with neurofilament accumulation seen in some neurodegenerative diseases