11 research outputs found
Human Listeriosis Caused by Listeria ivanovii
- Author
- Publication venue
- Centers for Disease Control and Prevention
- Publication date
- 01/01/2010
- Field of study
Two species of Listeria are pathogenic; L. monocytogenes infects humans and animals, and L. ivanovii has been considered to infect ruminants only. We report L. ivanovii–associated gastroenteritis and bacteremia in a man. This isolate was indistinguishable from prototypic ruminant strains. L. ivanovii is thus an enteric opportunistic human pathogen
The Genome of a Pathogenic Rhodococcus: Cooptive Virulence Underpinned by Key Gene Acquisitions
- Author
- A Bateman
- A Ghosh
- A Krogh
- A Mandlik
- A Theocharidis
- AA Ocampo-Sosa
- AH van Vliet
- AL Barabasi
- AL Delcher
- Alain Ocampo
- Alexia Hapeshi
- Ana Valero-Rello
- AP Underwood
- AW Maresso
- B Gonzalez-Zorn
- B Li
- B Said-Salim
- BA Byrne
- BG Kelly
- BR Bochner
- C Ratledge
- CD Sohaskey
- CJ Alteri
- D Bottai
- DA McLennan
- DA Russell
- Desmond Leadon
- DM Wall
- EF Mongodin
- EJ Muñoz-Elias
- F Dosselaere
- F Soriano
- G Muscatello
- GA Byrne
- GL Newton
- GM Zaitsev
- GS Vernikos
- H Baba
- H Matsuyama
- HD Park
- Héctor Rodríguez
- I Chico-Calero
- Iain MacArthur
- IM Keseler
- Inna Cherevach
- J Felsenstein
- J Ishikawa
- J Navas
- J Ren
- JA Vazquez-Boland
- JD Bendtsen
- JD McKinney
- JE Drumm
- Jesús Navas
- JF Prescott
- JH Yoon
- JH Yoon
- JJ May
- JL Martinez
- John F. Prescott
- Jolyon Holdstock
- Josep Casadesús
- José A. Vázquez-Boland
- JR True
- Julian Parkhill
- K Pethe
- K Potrykus
- K Rutherford
- K von Bargen
- KT Konstantinidis
- L Makrai
- LA Marraffini
- LG Wayne
- M Briglia
- M Duz
- M Eschbach
- M Goodfellow
- M Jain
- M Letek
- M Lynch
- M Miethke
- M Miyahi
- M Sekine
- M Seto
- M Strong
- M Tomich
- MA Florczyk
- MA Schell
- Mandy Sanders
- Mariela M. Scortti
- MD Ganfornina
- MI Voskuil
- Michael A. Quail
- Michal Letek
- MJ Larkin
- MK Hondalus
- MM McNeil
- MN Price
- MP McLeod
- MT Mascellino
- Mónica Blanco
- N Casali
- N Hulo
- NC Gey van Pittius
- NC Gey Van Pittius
- NC Martinez-Gomez
- P Nordmann
- Patricia González
- PD Karp
- PI Fields
- PJ Quinn
- R Colangeli
- R Miranda-CasoLuengo
- R Simeone
- R van der Geize
- R van der Geize
- R Wada
- Ruth Fahey
- S Chauhan
- S Griffiths-Jones
- S Kurtz
- S Malm
- S Mayilraj
- S McGinnis
- SD Bentley
- SD Bentley
- SJ Sasindran
- SK Parker
- SM Hingley-Wilson
- SM Joshi
- SS Jacks
- ST Cole
- Stephen D. Bentley
- SY Park
- T Haikarainen
- TC Freeman
- TJ Carver
- TM Wassenaar
- Tom Buckley
- Tom C. Freeman
- Ursula Fogarty
- V Foulongne
- V Gurtler
- V Puech
- Wim G. Meijer
- WW Mohn
- Y Chai
- Y Hong
- Y Pei
- YQ Zhang
- YX Wang
- Z Pragai
- Publication venue
- Public Library of Science
- Publication date
- 01/01/2010
- Field of study
We report the genome of the facultative intracellular parasite Rhodococcus equi, the only animal pathogen within the biotechnologically important actinobacterial genus Rhodococcus. The 5.0-Mb R. equi 103S genome is significantly smaller than those of environmental rhodococci. This is due to genome expansion in nonpathogenic species, via a linear gain of paralogous genes and an accelerated genetic flux, rather than reductive evolution in R. equi. The 103S genome lacks the extensive catabolic and secondary metabolic complement of environmental rhodococci, and it displays unique adaptations for host colonization and competition in the short-chain fatty acid–rich intestine and manure of herbivores—two main R. equi reservoirs. Except for a few horizontally acquired (HGT) pathogenicity loci, including a cytoadhesive pilus determinant (rpl) and the virulence plasmid vap pathogenicity island (PAI) required for intramacrophage survival, most of the potential virulence-associated genes identified in R. equi are conserved in environmental rhodococci or have homologs in nonpathogenic Actinobacteria. This suggests a mechanism of virulence evolution based on the cooption of existing core actinobacterial traits, triggered by key host niche–adaptive HGT events. We tested this hypothesis by investigating R. equi virulence plasmid-chromosome crosstalk, by global transcription profiling and expression network analysis. Two chromosomal genes conserved in environmental rhodococci, encoding putative chorismate mutase and anthranilate synthase enzymes involved in aromatic amino acid biosynthesis, were strongly coregulated with vap PAI virulence genes and required for optimal proliferation in macrophages. The regulatory integration of chromosomal metabolic genes under the control of the HGT–acquired plasmid PAI is thus an important element in the cooptive virulence of R. equi
A cellular deficiency of gangliosides causes hypersensitivity to Clostridium perfringens phospholipase C
- Author
- Alape-Girón
- Alberto Alape-Girón
- Awad
- Basañez
- Basu
- Bianco
- Bonadonna
- Brade
- Bruno Catimel
- Bunting
- Burke
- Catimel
- Clark
- Daniele
- Dinter
- Dohi
- Eaton
- Ed Nice
- Elbein
- Flores-Díaz
- Flores-Díaz
- Flores-Díaz
- Florin
- Ge Wei
- Graeme Clark
- Guarnaccia
- Helenius
- Ichikawa
- Jepson
- Jepson
- José-María Gutiérrez
- Karasawa
- Kazuya
- Kreutter
- Liu
- Lomonte
- Lunn
- Maggio
- Maggio
- Marietta Flores-Díaz
- Merrill
- Monica Thelestam
- Müthing
- Müthing
- Nagahama
- Nagahama
- Naylor
- Prydz
- Richard Titball
- Roggentin
- Roggentin
- Rood
- Rothe
- Schauer
- Schwarzmann
- Shimizu
- Sleight
- Songer
- Stevens
- Stonehouse
- Sutton
- Tettamanti
- Titball
- Titball
- Traving
- Tsai
- Vazquez-Boland
- Walker
- Williamson
- Yoshio Hirabayashi
- Yu
- Yusuf
- Zhao
- Publication venue
- 'American Society for Biochemistry & Molecular Biology (ASBMB)'
- Publication date
- 22/07/2005
- Field of study
Clostridium perfringens phospholipase C (Cp-PLC), also called alpha-toxin, is the major virulence factor in the pathogenesis of gas gangrene. Previously, a cellular UDP-Glc deficiency was related with a hypersensitivity to the cytotoxic effect of Cp-PLC. Because UDP-Glc is required in the synthesis of proteoglycans, N-linked glycoproteins, and glycosphingolipids, the role of these gly-coconjugates in the cellular sensitivity to Cp-PLC was studied. The cellular sensitivity to Cp-PLC was significantly enhanced by glycosphingolipid synthesis inhibitors, and a mutant cell line deficient in gangliosides was found to be hypersensitive to Cp-PLC. Gangliosides protected hypersensitive cells from the cytotoxic effect of Cp-PLC and prevented its membrane-disrupting effect on artificial membranes. Removal of sialic acids by C. perfringens sialidase increases the sensitivity of cultured cells to Cp-PLC and intramuscular co-injection of C. perfringens sialidase, and Cp-PLC in mice potentiates the myotoxic effect of the latter. This work demonstrated that a reduction in gangliosides renders cells more susceptible to the membrane damage caused by Cp-PLC and revealed a previously unrecognized synergism between Cp-PLC and C. perfringens sialidase, providing new insights toward understanding the pathogenesis of clostridial myonecrosis.UCR::Vicerrectoría de Investigación::Unidades de Investigación::Ciencias de la Salud::Instituto Clodomiro Picado (ICP
Broadband Multi-wavelength Properties of M87 during the 2017 Event Horizon Telescope Campaign
- Author
- Abdalla H.
- Acciari V. A.
- Adam R.
- Adams C. B.
- Aharonian F.
- Akiyama Kazunori
- Alberdi Antxon
- Alef Walter
- Algaba J. C.
- Anantua Richard
- Anczarski J.
- Angüner E. O.
- Ansoldi S.
- Antonelli L. A.
- Arcaro C.
- Armand C.
- Armstrong T.
- Artero M.
- Asada K.
- Asano K.
- Ashkar H.
- Azulay Rebecca
- Baack D.
- Babić A.
- Backes M.
- Baczko Anne-Kathrin
- Baghmanyan V.
- Ball David
- Baloković M.
- Baquero A.
- Barbosa Martins V.
- Barnacka A.
- Barnard M.
- Barrett John
- Barrio J. A.
- Becerra González J.
- Becherini Y.
- Bednarek W.
- Bellizzi L.
- Benbow W.
- Benkhali F. Ait
- Benson Bradford A.
- Berge D.
- Bernardini E.
- Bernardos M.
- Bernlöhr K.
- Berti A.
- Besenrieder J.
- Bhattacharyya W.
- Bi B.
- Bigongiari C.
- Biland A.
- Bintley Dan
- Blackburn Lindy
- Blanch O.
- Blundell Raymond
- Boisson C.
- Boland Wilfred
- Bolmont J.
- Bonnoli G.
- Bouman Katherine L.
- Bower Geoffrey C.
- Boyce Hope
- Bošnjak Ž.
- Bremer Michael
- Breuhaus M.
- Brill A.
- Brinkerink Christiaan D.
- Brissenden Roger
- Britzen Silke
- Broderick Avery E.
- Broguiere Dominique
- Bronzwaer Thomas
- Brun F.
- Brun P.
- Bryan M.
- Bulik T.
- Busetto G.
- Bylund T.
- Byun Do-Young
- Böttcher M.
- Büchele M.
- Capasso M.
- Carlstrom John E.
- Caroff S.
- Carosi A.
- Carosi R.
- Casanova S.
- Ceribella G.
- Cerruti M.
- Chael Andrew
- Chai Y.
- Chan Chi-kwan
- Chand T.
- Chandra S.
- Chatterjee Koushik
- Chatterjee Shami
- Chen A.
- Chen Ming-Tang
- Chen Yongjun
- Chesler Paul M.
- Chilingarian A.
- Cho Ilje
- Christian Pierre
- Christiansen J. L.
- Chromey A. J.
- Cikota S.
- Colak S. M.
- Colombo E.
- Contreras J. L.
- Conway John E.
- Cordes James M.
- Cortina J.
- Cotter G.
- Covino S.
- Crawford Thomas M.
- Crew Geoffrey B.
- Cruz-Osorio Alejandro
- Cui Lang
- Cui Y.-Z.
- Curyło M.
- Da Vela P.
- Damascene Mbarubucyeye J.
- Daniel M. K.
- Davelaar Jordy
- Davids I. D.
- Davies J.
- Dazzi F.
- de Almeida U. Barres
- De Angelis A.
- de Clairfontaine G. Fichet
- De Laurentis Mariafelicia
- de Lavergne M. de Bony
- De Lotto B.
- de Naurois M.
- de Ona Wilhelmi E.
- Deane Roger
- Deil C.
- Delfino M.
- Delgado Mendez C.
- Delgado J.
- Dempsey Jessica
- Depaoli D.
- Desvignes Gregory
- Devin J.
- deWilt P.
- Dexter Jason
- Di Pierro F.
- Di Venere L.
- Dirson L.
- Djannati-Ataï A.
- Dmytriiev A.
- Do Souto Espiñeira E.
- Doeleman Sheperd S.
- Dominis Prester D.
- Donath A.
- Donini A.
- Dorner D.
- Doro M.
- Doroshenko V.
- Duffy C.
- Dyks J.
- D’Amico G.
- D’Ammando F.
- D’Elia V.
- Eatough Ralph P.
- EAVN Collaboration
- Egberts K.
- Eichhorn F.
- Einecke S.
- Elsaesser D.
- Emery G.
- Engels A. Arbet
- Ernenwein J.-P.
- Errando M.
- Falcke Heino
- Falcone A. D.
- Farah Joseph
- Farrell K. A
- Fattorini A.
- Fegan S.
- Feijen K.
- Feng Q.
- Ferrara G.
- Fiasson A.
- Finley J. P.
- Fish Vincent L.
- Fomalont Ed
- Fonseca M. V.
- Font L.
- Fontaine G.
- Ford H. Alyson
- Fortson L.
- Fraga-Encinas Raquel
- Friberg Per
- Fromm Christian M.
- Fruck C.
- Fuentes Antonio
- Fukami S.
- Funk S.
- Furniss A.
- Füßling M.
- Gabici S.
- Galison Peter
- Gallant Y. A.
- Gammie Charles F.
- Garczarczyk M.
- García López R. J.
- García Roberto
- Gasparyan S.
- Gaug M.
- Gent A.
- Gentaz Olivier
- Georgiev Boris
- Giavitto G.
- Giglietto N.
- Giordano F.
- Giroletti M.
- Giunti L.
- Giuri C.
- Glawion D.
- Glicenstein J. F.
- Gliwny P.
- Goddi C.
- Godinović N.
- Gold Roman
- Gottschall D.
- Green D.
- Green J. G.
- Grondin M.-H.
- Gu Minfeng
- Gurwell Mark
- Gómez José L.
- Gómez-Ruiz Arturo I.
- H.E.S.S. Collaboration
- Hada K.
- Hadasch D.
- Haggard D.
- Hahn A.
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- Hassan T.
- Haupt M.
- Hecht Michael H.
- Heckmann L.
- Hermann G.
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- Hesper Ronald
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- Humensky T. B.
- Hörbe M.
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- Ikeda Shiro
- Inada T.
- Inoue Makoto
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- Ishio K.
- Issaoun Sara
- Iwamura Y.
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- Jankowsky D.
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- Jannuzi Buell T.
- Janssen Michael
- Jardin-Blicq A.
- Jeter Britton
- Jiang Wu
- Jiménez I.
- Jiménez-Rosales Alejandra
- Jin W.
- Johnson Michael D.
- Jormanainen J.
- Jorstad S.
- Joshi V.
- Jouvin L.
- Jung Taehyun
- Jung-Richardt I.
- Kaaret P.
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- Karami Mansour
- Karjalainen M.
- Karuppusamy Ramesh
- Kasai E.
- Kastendieck M. A.
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- Katz U.
- Kaur A.
- Kawashima T.
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- Kertzman M.
- Kettenis Mark
- Khangulyan D.
- Khélifi B.
- Kieda D.
- Kim Dong-Jin
- Kim J.-Y.
- Kim Jongsoo
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- Kino M.
- Klepser S.
- Kluźniak W.
- Koay Jun Yi
- Kobayashi Y.
- Koch Patrick M.
- Kofuji Yutaro
- Komin Nu.
- Komossa S.
- Konno R.
- Kosack K.
- Kostunin D.
- Koyama Shoko
- Kramer Carsten
- Kramer Michael
- Kravchenko E. V.
- Kreter M.
- Krichbaum T. P.
- Kubo H.
- Kumar S.
- Kuo Cheng-Yu
- Kushida J.
- Lamanna G.
- Lamastra A.
- Lang M. J.
- Lauer Tod R.
- Lee S.-S.
- Lelas D.
- Lemière A.
- Lemoine-Goumard M.
- Lenain J.-P.
- Leone F.
- Levis Aviad
- Levy C.
- Li Yan-Rong
- Li Zhiyuan
- Lico Rocco
- Lindahl Greg
- Lindfors E.
- Lindqvist Michael
- Liu Jun
- Liu Kuo
- Liu Xiang
- Liuzzo Elisabetta
- Lo Wen-Ping
- Lobanov Andrei P.
- Lohse T.
- Loinard Laurent
- Lombardi S.
- Longo F.
- Lonsdale Colin
- Loporchio S.
- Lu R.-S.
- Lucchini M.
- Lundy M.
- Lypova I.
- López-Coto R.
- López-Moya M.
- López-Oramas A.
- MacDonald Nicholas R.
- Machado de Oliveira Fraga B.
- Mackey J.
- Maggio C.
- MAGIC Collaboration
- Maier G.
- Majumdar J.
- Majumdar P.
- Makariev M.
- Mallamaci M.
- Malyshev D.
- Malyshev D.
- Maneva G.
- Manganaro M.
- Mannheim K.
- Mao Jirong
- Marandon V.
- Maraschi L.
- Marchegiani P.
- Marchili Nicola
- Marcowith A.
- Mares A.
- Mariotti M.
- Markoff S.
- Marrone Daniel P.
- Marscher Alan P.
- Martí-Devesa G.
- Martí-Vidal Iván
- Martínez M.
- Marx R.
- Matsushita Satoki
- Matthews Lynn D.
- Maurin G.
- Mazin D.
- Medeiros Lia
- Meintjes P. J.
- Mejías Alejandro Mus
- Menchiari S.
- Mender S.
- Menten Karl M.
- Meyer M.
- Miceli D.
- Miener T.
- Minev M.
- Miranda J. M.
- Mirzoyan R.
- Mizuno Izumi
- Mizuno Yosuke
- Mićanović S.
- Moderski R.
- Mohamed M.
- Mohrmann L.
- Molina E.
- Montanari A.
- Moore C.
- Moralejo A.
- Moran James M.
- Morcuende D.
- Moreno V.
- Moretti E.
- Moriarty P.
- Moriyama Kotaro
- Moroni P. G. Prada
- Morris P.
- Moscibrodzka Monika
- Moulin E.
- Mukherjee R.
- Muller J.
- Murach T.
- Musoke Gibwa
- Müller Cornelia
- Nagai Hiroshi
- Nagar Neil M.
- Nakamura Masanori
- Nakashima K.
- Narayan Ramesh
- Narayanan Gopal
- Natarajan Iniyan
- Nathanail Antonios
- Nayerhoda A.
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- Neilsen J.
- Neri Roberto
- Neustroev V.
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- Nigro C.
- Niinuma Kotaro
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- Nowak M. A.
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- Odaka H.
- Ohm S.
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- Okino Hiroki
- Olivares Héctor
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- Sembroski G. H.
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- Shang R.
- Shao Lijing
- Shen Zhiqiang
- Shiningayamwe K.
- Simoni R.
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- Sitarek J.
- Small Des
- Sobczynska D.
- Sohn Bong Won
- Sol H.
- SooHoo Jason
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- Spolon A.
- Stamerra A.
- Stawarz Ł.
- Steenkamp R.
- Stegmann C.
- Steinmassl S.
- Steppa C.
- Strom D.
- Strzys M.
- Suda Y.
- Sun He
- Sun L.
- Surić T.
- Sánchez Salvador
- Sánchez-Arguelles David
- Takahashi M.
- Takahashi T.
- Tavecchio F.
- Tavernier T.
- Taylor A. M.
- Tazaki Fumie
- Temnikov P.
- Terrier R.
- Terzić T.
- Teshima M.
- Tetarenko Alexandra J.
- The Event Horizon Telescope Collaboration
- The Fermi Large Area Telescope Collaboration
- Tiede Paul
- Tilanus Remo P. J.
- Titus Michael
- Tiziani D.
- Tluczykont M.
- Toma Kenji
- Tomankova L.
- Torne Pablo
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- Trippe Sascha
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- van Scherpenberg J.
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- Vanzo G.
- Vasileiadis G.
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- Veh J.
- Venter C.
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- VERITAS Collaboration
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- Vincent P.
- Vink J.
- Vitale V.
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- Vuillaume T.
- Völk H. J.
- Wadiasingh Z.
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- Wagner S. J.
- Wajima Kiyoaki
- Wang Na
- Ward-Thompson Derek
- Wardle John
- Watson J.
- Weinstein A.
- Weintroub Jonathan
- Werner F.
- Wex Norbert
- Wharton Robert
- White R.
- Wielgus Maciek
- Wierzcholska A.
- Will M.
- Williams D. A.
- Williamson K. E.
- Williamson T. J
- Wong George N.
- Wong Yu Wun
- Wu Qingwen
- Wunderlich C.
- Yonekura Yoshinori
- Yoon Doosoo
- Young André
- Young Ken
- Younsi Ziri
- Yuan Feng
- Yuan Ye-Fei
- Yusafzai A.
- Zacharias M.
- Zanin R.
- Zargaryan D.
- Zarić D.
- Zdziarski A. A.
- Zech A.
- Zensus J. Anton
- Zhao Guang-Yao
- Zhao Shan-Shan
- Zhu S. J.
- Zorn J.
- Zouari S.
- Özel Feryal
- Šnidarić I.
- Żywucka N.
- Publication venue
- 'American Astronomical Society'
- Publication date
- 01/01/2021
- Field of study
Abstract: In 2017, the Event Horizon Telescope (EHT) Collaboration succeeded in capturing the first direct image of the center of the M87 galaxy. The asymmetric ring morphology and size are consistent with theoretical expectations for a weakly accreting supermassive black hole of mass ∼6.5 × 109 M ⊙. The EHTC also partnered with several international facilities in space and on the ground, to arrange an extensive, quasi-simultaneous multi-wavelength campaign. This Letter presents the results and analysis of this campaign, as well as the multi-wavelength data as a legacy data repository. We captured M87 in a historically low state, and the core flux dominates over HST-1 at high energies, making it possible to combine core flux constraints with the more spatially precise very long baseline interferometry data. We present the most complete simultaneous multi-wavelength spectrum of the active nucleus to date, and discuss the complexity and caveats of combining data from different spatial scales into one broadband spectrum. We apply two heuristic, isotropic leptonic single-zone models to provide insight into the basic source properties, but conclude that a structured jet is necessary to explain M87’s spectrum. We can exclude that the simultaneous γ-ray emission is produced via inverse Compton emission in the same region producing the EHT mm-band emission, and further conclude that the γ-rays can only be produced in the inner jets (inward of HST-1) if there are strongly particle-dominated regions. Direct synchrotron emission from accelerated protons and secondaries cannot yet be excluded
Evaluation of appendicitis risk prediction models in adults with suspected appendicitis
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- Abbas Sh
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- Abbott T
- Abdelgadir Am
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- Abellán Am
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- Acosta A
- Adam Me
- Adams Re
- Adegbola So
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- Mahoney R
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- Maina A
- Makhija R
- Malabarba S
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- Manias T
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- Mansour Mm
- Mansour S
- Maqboul F
- Maragouthakis D
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- Maretto I
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- Oliva I
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- Orizu M
- Orizu M
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- Padilla-Valverde D
- Paget C
- Pais M
- Pala M
- Palani-Velu Lk
- Palani-Velu Lk
- Pan Y
- Panagiotopoulos Sp
- Panda N
- Panda N
- Panda N
- Pandey V
- Pandya D
- Pandya R
- Paniagua M
- Pankin Gp
- Papandrea M
- Parajó Ae
- Paramasevon Kr
- Pareja-Ciuró F
- Parisi A
- Park Jh
- Park Jh
- Parkola Mj
- Parra Jm
- Parwaiz I
- Pascua-Sole M
- Pascual-Miguelañez I
- Pasquali S
- Pata F
- Pata F
- Pata F
- Pata F
- Pata F
- Pata F.
- Pata G
- Pata G
- Pata G
- Patel As
- Patel By
- Patel By
- Patel C
- Patel H
- Patel Mm
- Patel N
- Patel Pk
- Patel Rt
- Patil Sd
- Patti S
- Pau R
- Payne Cj
- Payne Re
- Payá-Llorente C
- Payá-Llorente C
- Peacock M
- Pearce J
- Pearce J
- Pearce L
- Pearce L
- Pearson R
- Pedder A
- Peirce Cb
- Peiris Gb
- Peixoto R
- Peleki A
- Peleki A
- Pellegrino L
- Pellicanò Ga
- Pellicer-Franco E
- Pellino G
- Pento V
- Pento V
- Peponis C
- Peprah D
- Pereira A
- Pereira Am
- Pereira J
- Pereira-Mosquera E
- Perera Mi
- Perez-Calvo J
- Perin A
- Pertile D
- Pertile D
- Peña-Barturen C
- Phelan L
- Photiou D
- Pierre R
- Pietrabissa A
- Pigem A
- Pila U
- Pilkington Jp
- Pineño-Flores C
- Pinillos-Somalo A
- Pinkney Td
- Pinkney Td
- Pinkney Td
- Pinna E
- Pino-Perez O
- Pirari Pf
- Pisanu A
- Piu F
- Planellas P
- Plua-Muniz Kt
- Poacher A
- Podda F
- Podda M
- Podda M
- Podda M
- Poillucci G
- Pollard H
- Ponchietti L
- Popova D
- Poudevigne M
- Prats Ma
- Prideaux A
- Prieto-Nieto Mi
- Primo Jc
- Pronin S
- Provenza G
- Puerta E
- Pulighe F
- Pullabatla-Venkata Up
- Punj S
- Pérez-Sanchez Le
- Quddus A
- Quill S
- Quinn Em
- Quinn Hc
- Rabie M
- Rabie Ma
- Rabie Mr
- Radwan Rw
- Radwan Rw
- Rahim A
- Rahman M
- Rahmani Ls
- Rajagopal S
- Rajaram R
- Rajaretnam N
- Rajjoub Y
- Rallage H
- Ramcharan S
- Ramirez L
- Ramirez-Redondo Aa
- Ramos Xh
- Ramos-Bernado Mi
- Ramírez-Faraco M
- Ranathunga S
- Rangarajan K
- Rao M
- Rao V
- Raofi A
- Rashid M
- Rate A
- Ravindran R
- Raymond M
- Raza Ss
- Recreo Ac
- Reddy A
- Reddy A
- Redmond Ae
- Redondo E
- Redondo E
- Redondo-Calvo Fj
- Reese G
- Regina G
- Rehman S
- Rehman S
- Rekhraj S
- Ren Kz
- Renshaw S
- Renshaw S
- Renzi Cr
- Resende Fm
- Rezacova M
- Rezvani S
- Riaz W
- Riba-Combatti L
- Ribaudo M
- Ribeiro B
- Rich Je
- Richardson Td
- Ridaura N
- Riera E
- Rigby S
- Rigney B
- Rinkoff S
- Ripoli Mc
- Robb Hd
- Robertson C
- Robinson A
- Robinson A
- Robinson D
- Robinson D
- Rocha R
- Rodger V
- Rodicio-Miravalles Jl
- Rodriguez L
- Rodriguez-Lopez M
- Rodriguez-Lopez M
- Rodriguez-Lopez M
- Rodríguez Ec
- Rojo Ja
- Roldán-Ortiz S
- Rolph R
- Romano J
- Romano R
- Romario Uf
- Romoli L
- Roncero Ls
- Ronda Rn
- Roomi S
- Rosa Mj
- Rosat A
- Roscio F
- Roscio F
- Roscio F
- Rossi C
- Rossi D
- Rossi Gm
- Roth N
- Rothnie K
- Roxburgh C
- Roy C
- Ruano A
- Rubbini M
- Rudland I
- Ruffolo C
- Rufo E
- Ruggiu Gv
- Ruiz-Marín M
- Ruiz-Marín M
- Rupani S
- Rupasinghe Sn
- Rupasinghe Sn
- Rutherford Dg
- Ruzvidzo F
- Ruzzenente A
- Saad M
- Saad M
- Saavedra-Chacón M
- Saba A
- Sabia D
- Sacco R
- Sacks R
- Sadek S
- Saghir N
- Sagnotta A
- Sagnotta A
- Saha A
- Sahay Sj
- Sahnan K
- Sahnan K
- Sainz B
- Sainz B
- Sajid Ms
- Salama Y
- Salamone G
- Salamone G
- Salamone G
- Salamone G
- Salandini Mc
- Salem A
- Salim S
- Salva Ab
- Salvador H
- Samartin C
- Sammarco G
- Sammarco G
- Samuel M
- Sana S
- Sanchez Er
- Sanchez Er
- Sanchez L
- Sanchez-Garcia S
- Sanchez-Guillen L
- Sanchez-Guillen L
- Sanchez-Martinez A
- Sancho-Muriel J
- Sandu L
- Sanna S
- Santamaria C
- Santamaría Pc
- Santarrufina-Martínez S
- Santos Sc
- Santurro L
- Sanz-Navarro S
- Sarmah P
- Sarmah P
- Sarmah P
- Sarveswaran J
- Sasia D
- Sasia D
- Saunders S
- Savill A
- Savino G
- Savino G
- Savioli F
- Scabini S
- Scabini S
- Scabini S
- Scandroglio Is
- Scanlon K
- Scatizzi M
- Scialandrone G
- Scricciolo M
- Sebastian Jf
- Sebastián-Tomás Jc
- Seddon Tc
- Segalini E
- Segura-Sampedro Jj
- Sena G
- Sena-Ruiz F
- Seneviratne N
- Sepe C
- Serventi F
- Serventi F
- Seth M
- Setshwaelo T
- Sezen E
- Sgardelis P
- Sgrò A
- Sgrò A
- Sgrò A
- Shah J
- Shah K
- Shah Sm
- Shah Sm
- Shaikh Ia
- Shakoor Z
- Shanmuganathan V
- Shanmugarajah K
- Sharma A
- Sharma A
- Sharma P
- Sharp Ol
- Sharp Ol
- Shaw Av
- Shepherd Ja
- Sherif Ma
- Shet S
- Shetty Vd
- Shingler G
- Shiwani Mh
- Shrestha D
- Shurlock J
- Sian T
- Siaw O
- Siddique K
- Siddiqui Mn
- Siddiqui Za
- Sierra-Grañón Je
- Siggens Kl
- Sihra N
- Silva A
- Silva I
- Silvestri V
- Simioni A
- Simmonds L
- Simmonds L
- Simo V
- Simoes J
- Simpson Dj
- Singh A
- Singh J
- Singh P
- Singh S
- Singhal T
- Singhal T
- Sivaloganathan P
- Skalamera I
- Skerritt C
- Slezak I
- Smallcombe N
- Smart Cj
- Smart Cj
- Smart Nj
- Smart Nj
- Smoker H
- Soares A. S.
- Soares As
- Soares As
- Soares As
- Soares As
- Soares As
- Soh B
- Solaini L
- Solar-García L
- Soliani P
- Solinas L
- Sooriyamoorthy T
- Soria-Aledo V
- Soria-Aledo V
- Soriano Jt
- Sorrentino L
- Sousa Hs
- Souter J
- Sparta C
- Spaziani A
- Speake D
- Speake D
- Springate El
- Sreedharan L
- Sreedharan L
- Staderini F
- Stecca T
- Stella M
- Stephens Gf
- Stephens Gf
- Stevenson R
- Stewart Dj
- Stoica I
- Storey R
- Stoyanov Ti
- Strachan E
- Strange Ja
- Stubbs Bm
- Stupalkowska W
- Stupalkowska W
- Suarez-Cabrera A
- Suero Ca
- Sultana A
- Summerfield L
- Sunter H
- Surg Pt
- Suriyakumar S
- Suárez-Sánchez A
- Swords C
- Symons N
- Szentpali K
- Szucs A
- Szucs A
- Sánchez-Cifuentes A
- Sánchez-Fuentes Mn
- Sánchez-Rubio M
- Tabain V
- Taglietti L
- Tague Le
- Tahir W
- Tailor K
- Tallon-Aguilar L
- Tallon-Aguilar L
- Tamayo-López Mj
- Tamborska A
- Tamini N
- Tamini N
- Tamini N
- Tan Cy
- Tan Cy
- Tan E
- Tan Hl
- Tan S
- Tang Am
- Tapiolas I
- Tarazi M
- Tatulli F
- Tay Yh
- Tayeh S
- Taylor M
- Taylor Ns
- Taylor Ns
- Taze D
- Tee A
- Tejero-Pintor Fj
- Tenconi Sm
- Tezas S
- Thaha Ma
- Thakral N
- Thakur D
- Thava B
- Thavanesan N
- Thavanesan N
- Thaventhiran Aj
- Theodoropoulou K
- Thomas At
- Thomas L
- Thompson C
- Thompson Db
- Thompson Db
- Thompson R
- Thompson R
- Thoukididou Sn
- Tiedt La
- Tiedt La
- Ting N
- Tinoco-González J
- Tinsley Bj
- Tognarelli Jm
- Tojal A
- Tokidis E
- Tomasoni M
- Tonini V
- Toomey D
- Toomey Db
- Torkington J
- Torkington J
- Torrado Aa
- Torrance A
- Torrance A
- Townsend Dc
- Townsend Dc
- Tozer Pj
- Trail M
- Trail M
- Trastulli S
- Trew F
- Trostchansky I
- Trujillo-Diaz Jj
- Tsang B
- Tudyka V
- Tudyka V
- Turnbull A
- Turner Ej
- Tutino R
- Twum-Barima Cs
- Twum-Barima Cs
- Tyler R
- Tyler R
- Ugarte-Sierra B
- Vacca A
- Vaccari S
- Vakis S
- Valente Pm
- Valiani Sv
- Vallejo-Bernad C
- Vallve-Bernal M
- Van Boxel Gi
- Vance-Daniel J
- Vannucchi A
- Varcada M
- Vargas-Pierola Hj
- Vaughan Em
- Vaughan Em
- Vazquez-Fernandez Ap
- Vega L
- Velchuru Vr
- Velho R
- Venkata Up
- Venkatasubramaniam Ak
- Venn Ml
- Venn Ml
- Venugopal R
- Verea S
- Veres T
- Veres T
- Verroiotou M
- Vescio G
- Vettoretto N
- Vigorita V
- Vijay V
- Vila-Zarate C
- Villarejo-Campos P
- Vinnicombe Z
- Viscosi F
- Vitish-Sharma P
- Viviani E
- Viñas Nl
- Vohra R
- Vohra R
- Vulcano I
- Waite K
- Walji Hd
- Walsh E
- Walsh Tn
- Walters Kj
- Walters U
- Wardle Bg
- Wardle Bg
- Wardle Sd
- Warren O
- Warren Oj
- Warusavitarne J
- Watfah J
- Watson N
- Wauchope J
- Weatherburn Lw
- Weaver J
- Weegenaar Cr
- Weegenaar Cr
- Welsh S
- Wensley F
- West H
- West H
- Wheatstone S
- Wheeler C
- Whewell He
- White F
- Whitehorn Se
- Whitehorn Se
- Whitehouse P
- Whiteman E
- Whittaker L
- Wiggill S
- Wijesundera K
- Wilcox G
- Wilkin R
- Wilkin R
- Wilkin R
- Wilkin R
- Wilkin R. J. W.
- Williams Gl
- Williams M
- Williams R
- Williams S
- Wilson Ej
- Wilson M
- Winter Dc
- Winter Dc
- Wolff J
- Wong A
- Wong C
- Wong J
- Wong J
- Wong Ml
- Wong Sy
- Woo R
- Wood Cs
- Woodrow C
- Woodward A
- Woodward B
- Woodward B
- Worku D
- Worku D
- Wright E
- Wright Hl
- Wu F
- Xidas A
- Yalamarthi S
- Yang P
- Yanni F
- Yardimci E
- Yasin T
- Yen Sk
- Yeung K
- Yeung K
- Yoganathan S
- Yoong S
- Youssef H
- Yow L
- Yow L
- Zaborowski A
- Zadi Az
- Zalla T
- Zarka Za
- Zarka Za
- Zarog Ma
- Zelazek M
- Zerpa C
- Zhang Ay
- Zhou S
- Zorrilla L
- Zuin M
- Zurleni Tz
- Publication venue
- 'Wiley'
- Publication date
- 01/01/2019
- Field of study
Background
Appendicitis is the most common general surgical emergency worldwide, but its diagnosis remains challenging. The aim of this study was to determine whether existing risk prediction models can reliably identify patients presenting to hospital in the UK with acute right iliac fossa (RIF) pain who are at low risk of appendicitis.
Methods
A systematic search was completed to identify all existing appendicitis risk prediction models. Models were validated using UK data from an international prospective cohort study that captured consecutive patients aged 16–45 years presenting to hospital with acute RIF in March to June 2017. The main outcome was best achievable model specificity (proportion of patients who did not have appendicitis correctly classified as low risk) whilst maintaining a failure rate below 5 per cent (proportion of patients identified as low risk who actually had appendicitis).
Results
Some 5345 patients across 154 UK hospitals were identified, of which two‐thirds (3613 of 5345, 67·6 per cent) were women. Women were more than twice as likely to undergo surgery with removal of a histologically normal appendix (272 of 964, 28·2 per cent) than men (120 of 993, 12·1 per cent) (relative risk 2·33, 95 per cent c.i. 1·92 to 2·84; P < 0·001). Of 15 validated risk prediction models, the Adult Appendicitis Score performed best (cut‐off score 8 or less, specificity 63·1 per cent, failure rate 3·7 per cent). The Appendicitis Inflammatory Response Score performed best for men (cut‐off score 2 or less, specificity 24·7 per cent, failure rate 2·4 per cent).
Conclusion
Women in the UK had a disproportionate risk of admission without surgical intervention and had high rates of normal appendicectomy. Risk prediction models to support shared decision‐making by identifying adults in the UK at low risk of appendicitis were identified
Mouse lung infection model to assess Rhodococcus equi virulence and vaccine protection
- Author
- Alexia Hapeshi
- Ashour
- Auerbuch
- Beuzon
- Bowles
- Bowles
- Chiang
- Chirino-Trejo
- Dawson
- Giguère
- Giguère
- Hondalus
- Hondalus
- Hooper-McGrevy
- Héctor Rodriguez
- Iain MacArthur
- Jain
- John F. Prescott
- José A. Vazquez-Boland
- Kanaly
- Kanaly
- Knowles
- Ladron
- Letek
- Letek
- Lopez
- MacArthur
- Mackaness
- Mann
- Mariela Scortti
- Miranda-Casoluengo
- Muscatello
- Mutimer
- Navas
- Nordmann
- Patricia González-Iglesias
- Pei
- Phumoonna
- Prescott
- Prescott
- Ren
- Schlusselhuber
- Southam
- Takai
- Takai
- Takai
- Takai
- Takai
- Taylor
- van der Geize
- Vazquez-Boland
- von Bargen
- Wada
- Wall
- Whitehead
- Yager
- Yamshchikov
- Publication venue
- 'Elsevier BV'
- Publication date
- Field of study
Deletion of the membrane protein Lmo0412 increases the virulence of Listeria monocytogenes
- Author
- Publication venue
- 'Elsevier BV'
- Publication date
- Field of study
Identification of an IS6110 insertion site in plcD, the unique phospholipase C gene of Mycobacterium bovis
- Author
- Angel Cataldi
- Behr
- Berka
- Brosch
- Cesar Alejandro Rosales Rodriguez
- Cole
- Cristina Viana-Niero
- Eisenach
- Fabiana Bigi
- Fang
- Fang
- Garnier
- Gordon
- Groenen
- Haddad
- Hermans
- Ho
- José Soares Ferreira-Neto
- Kamerbeek
- Kong
- Lari
- Logan
- Marcos Santos Zanini
- Nguyen
- Raynaud
- Sampson
- Sylvia Cardoso Leão
- Talarico
- van Embden
- van Embden
- Vazquez-Boland
- Vera-Cabrera
- Vestal
- Viana-Niero
- Wall
- Warren
- Warren
- Wayne
- Yang
- Yesilkaya
- Zanini
- Zanini
- Publication venue
- 'Microbiology Society'
- Publication date
- Field of study
Elective Cancer Surgery in COVID-19–Free Surgical Pathways During the SARS-CoV-2 Pandemic: An International, Multicenter, Comparative Cohort Study
- Author
- Aawsaj Y
- Abad Gurumeta A
- Abad-Motos A
- Abate E
- Abatini C
- Abbadessa F
- Abbas AM
- Abbassi-Ghadi N
- Abbott D
- Abbott T
- Abbott Tom EF
- Abd Elazeem HAS
- Abdalla M
- Abdallah M
- Abdel Al S
- Abdel Jalil R
- Abdeldayem H
- Abdelkader Salama I
- Abdelkarem MM
- Abdelkarim M
- Abdelmajeed A
- Abdelrahman A
- Abdelrahman S
- Abdelsamed A
- Abdou M
- Abdulkareem A
- Abdulwahed E
- Abdur-Rahman L
- Abel MK
- Abellán M
- Aboelkassem Ibrahim A
- Abosamak NE
- Abou Chaar MK
- Abou Chaar Mohammad K.
- Abou-Khalil J
- Abouassi A
- Aboulkassem H
- Abreu da Silva A
- Abu Za’nouneh FJ
- Abu J
- Abu-Nayla I
- Abubakar A
- Abukhalaf Sadi
- Acebes García F
- Achalandabaso Boira M
- Acher A
- Acrich E
- Adamina M
- Adamina Michel
- Adamoli L
- Addae-Boateng E
- Ademuyiwa Adesoji O
- Aderombi A
- Adeyeye A
- Adiamah A
- Adishesh M
- Agapov M
- Agarwal Arnav
- Aggarwal A
- Aghayeva A
- Agilinko J
- Agnes A
- Agostini C
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- Olivos Maricarmen
- Olona C
- Olson K
- Olulana DI
- Omar Omar
- on behalf of the COVIDSurg Collaborative
- Onan MA
- Ong BS
- Ong EC
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- Ooi R
- Oosterlinck W
- Oosterling S
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- Orhan N
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- Publication venue
- American Society of Clinical Oncology
- Publication date
- 01/01/2021
- Field of study
Delaying surgery for patients with a previous SARS-CoV-2 infection
- Author
- A A Ali Karar
- A A Kerawala
- A A Marra
- A Abad Gurumeta
- A Abad-Motos
- A Abdelmajeed
- A Abdelrahman
- A Abdelsamed
- A Abdulkareem
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- V Oktseloglou
- V Ozben
- V Papadopoulos
- V Picotti
- V Pinto
- V Pla-Marti
- V Pérez Simón
- V Quintodei
- V Rizzo
- V Rossi
- V S Ban
- V S Kolli
- V S Rodrigo
- V Testa
- V Tonini
- V Tsaousis
- V Turrado-Rodriguez
- V Valbuena Jabares
- V Valtzoglou
- V Velchuru
- V Vigorita
- V Vujanac
- V Yip
- V Zamvar
- V Šćepanović
- Veeru Kasivisvanathan
- W Butt
- W Campbell
- W Cymes
- W Garrett
- W H Khan
- W J Wong
- W Knight
- W Lee
- W Marx
- W McCormick
- W McGahan
- W Mugla
- W Oosterlinck
- W Raby-Smith
- W Smolka
- W Van Houdt
- W Yang
- Willemijn van der Plas
- Wong Mpk
- X De Sousa
- X Morales
- X S Tan
- Y Aawsaj
- Y Al-Tamimi
- Y Arkha
- Y Ayasra
- Y Bashir
- Y El Bouazizi
- Y Fayed
- Y H Lam
- Y Kanemitsu
- Y Kara
- Y Kirmizi
- Y Levy-Zauberman
- Y Litvina
- Y Perez
- Y T Liew
- Y Tanase
- Y Viswanath
- Y Ying
- Z Al-Ishaq
- Z Aldayri
- Z Aliyeva
- Z Bayhan
- Z Chia
- Z Dzamic
- Z H Belkhadir
- Z Inic
- Z Jawad
- Z Jezdic
- Z Katusic
- Z Krivokapic
- Z Lakkis
- Z Li
- Z M Barrett-Brown
- Z Mahasin
- Z Seymour
- Z Vilendecic
- Z Zakaria
- Á De la Hoz Rodríguez
- Á Fernández Camuñas
- É Ryan
- Ž Grubač
- А Камалов
- Publication venue
- 'Wiley'
- Publication date
- 01/01/2020
- Field of study
Not availabl