Kundera and Ionesco on the Unmistakable Awareness of Being Minor

Deleuze and Guattari’s 1975 text, Kafka, pour une littérature mineure, posited a theory concerning some groups of literary texts including those of Franz Kafka. Their theory was nevertheless highly connected to their own historical and geographical context in France, and much less so with that of Kafka who had himself previously attempted to theorize small literatures. By looking at the context of Kafka and of two other writers who might be considered as belonging to minor literary contexts, I argue that theorists of minor literature tend to view minor literature in a positive way when their own cultural context is further from nation-state building. On the other hand, those writers who are writing from inside nation-building contexts tend to emphasize minor literature’s limits on literary production. Interestingly, Milan Kundera and Eugene Ionesco who had first-hand experience of nation-building contexts, but then moved to France and wrote in French, take more nuanced views of minor literatures as they are further removed in time and space from their original minor contexts

Differential subordinations using ruscheweyh derivative and Sălăgean operator

In the present paper we study the operator defined by using the Ruscheweyh derivative Rm f(z) and the Sălăgean operator Sm f(z), denoted Lmα : An → An, Lmα f(z) = (1−α)Rm f(z)+αSm f(z), z ∈ U, where An = {f ∈ H(U) : f(z) = z+an+1zn+1+. . . , z ∈ U} is the class of normalized analytic functions. We obtain several differential subordinations regarding the operator Lmα.Publisher's Versio

Domain annotation of trimeric autotransporter adhesins—daTAA

Motivation: Trimeric autotransporter adhesins (TAAs), such as Yersinia YadA, Neisseria NadA, Moraxella UspAs, Haemophilus Hia and Bartonella BadA, are important pathogenicity factors of proteobacteria. Their high sequence diversity and distinct mosaic-like structure lead to difficulties in the annotation of their sequences. These stem from the large number of short repeats, the presence of compositionally unusual coiled-coils, fuzzy domain boundaries and regions of seemingly low sequence complexity

Evolution of the beta-propeller fold.

β-Propellers are toroidal folds, in which repeated, four-stranded β-meanders are arranged in a circular and slightly tilted fashion, like the blades of a propeller. They are found in all domains of life, with a strong preponderance among eukaryotes. Propellers show considerable sequence diversity and are classified into six separate structural groups by the SCOP and CATH databases. Despite this diversity, they often show similarities across groups, not only in structure but also in sequence, raising the possibility of a common origin. In agreement with this hypothesis, most propellers group together in a cluster map of all-β folds generated by sequence similarity, because of numerous pairwise matches, many of which are individually nonsignificant. In total, 45 of 60 propellers in the SCOP25 database, covering four SCOP folds, are clustered in this group and analysis with sensitive sequence comparison methods shows that they are similar at a level indicative of homology. Two mechanisms appear to contribute to the evolution of β-propellers: amplification from single blades and subsequent functional differentiation. The observation of propellers with nearly identical blades in genomic sequences show that these mechanisms are still operating today

REPPER—repeats and their periodicities in fibrous proteins

REPPER (REPeats and their PERiodicities) is an integrated server that detects and analyzes regions with short gapless repeats in protein sequences or alignments. It finds periodicities by Fourier Transform (FTwin) and internal similarity analysis (REPwin). FTwin assigns numerical values to amino acids that reflect certain properties, for instance hydrophobicity, and gives information on corresponding periodicities. REPwin uses self-alignments and displays repeats that reveal significant internal similarities. Both programs use a sliding window to ensure that different periodic regions within the same protein are detected independently. FTwin and REPwin are complemented by secondary structure prediction (PSIPRED) and coiled coil prediction (COILS), making the server a versatile analysis tool for sequences of fibrous proteins. REPPER is available at

The HHpred interactive server for protein homology detection and structure prediction

HHpred is a fast server for remote protein homology detection and structure prediction and is the first to implement pairwise comparison of profile hidden Markov models (HMMs). It allows to search a wide choice of databases, such as the PDB, SCOP, Pfam, SMART, COGs and CDD. It accepts a single query sequence or a multiple alignment as input. Within only a few minutes it returns the search results in a user-friendly format similar to that of PSI-BLAST. Search options include local or global alignment and scoring secondary structure similarity. HHpred can produce pairwise query-template alignments, multiple alignments of the query with a set of templates selected from the search results, as well as 3D structural models that are calculated by the MODELLER software from these alignments. A detailed help facility is available. As a demonstration, we analyze the sequence of SpoVT, a transcriptional regulator from Bacillus subtilis. HHpred can be accessed at

The MPI bioinformatics Toolkit as an integrative platform for advanced protein sequence and structure analysis.

The MPI Bioinformatics Toolkit (http://toolkit.tuebingen.mpg.de) is an open, interactive web service for comprehensive and collaborative protein bioinformatic analysis. It offers a wide array of interconnected, state-of-the-art bioinformatics tools to experts and non-experts alike, developed both externally (e.g. BLAST+, HMMER3, MUSCLE) and internally (e.g. HHpred, HHblits, PCOILS). While a beta version of the Toolkit was released 10 years ago, the current production-level release has been available since 2008 and has serviced more than 1.6 million external user queries. The usage of the Toolkit has continued to increase linearly over the years, reaching more than 400 000 queries in 2015. In fact, through the breadth of its tools and their tight interconnection, the Toolkit has become an excellent platform for experimental scientists as well as a useful resource for teaching bioinformatic inquiry to students in the life sciences. In this article, we report on the evolution of the Toolkit over the last ten years, focusing on the expansion of the tool repertoire (e.g. CS-BLAST, HHblits) and on infrastructural work needed to remain operative in a changing web environment

TPRpred: a tool for prediction of TPR-, PPR- and SEL1-like repeats from protein sequences

BACKGROUND: Solenoid repeat proteins of the Tetratrico Peptide Repeat (TPR) family are involved as scaffolds in a broad range of protein-protein interactions. Several resources are available for the prediction of TPRs, however, they often fail to detect divergent repeat units. RESULTS: We have developed TPRpred, a profile-based method which uses a P-value-dependent score offset to include divergent repeat units and which exploits the tendency of repeats to occur in tandem. TPRpred detects not only TPR-like repeats, but also the related Pentatrico Peptide Repeats (PPRs) and SEL1-like repeats. The corresponding profiles were generated through iterative searches, by varying the threshold parameters for inclusion of repeat units into the profiles, and the best profiles were selected based on their performance on proteins of known structure. We benchmarked the performance of TPRpred in detecting TPR-containing proteins and in delineating the individual repeats therein, against currently available resources. CONCLUSION: TPRpred performs significantly better in detecting divergent repeats in TPR-containing proteins, and finds more individual repeats than the existing methods. The web server is available at , and the C++ and Perl sources of TPRpred along with the profiles can be downloaded from

Ionesco contre la littérature mineure ? Le cas de la littérature roumain

Des études récentes ont développé une notion appelée de diverses manières : celle des littératures mineures ou celle des littératures des petites nations ou encore celle des petites littératures. Milan Kundera, qui vient de voir ses œuvres publiées dans la bibliothèque de la Pléiade et qui entre ainsi dans un groupe très restreint de créateurs, a réservé dans ses essais une place importante à l’art des ‘petites nations’. Mais déjà en 1955, dans un article sur la littérature roumaine destiné à..