Perfil de Expresión Génica en Hipocampo de Ratones Idosos Tratados con Psidium cattleyanum

El objetivo de éste trabajo fue evaluar el efecto de la administración oral prolongada (1000 mg/kg, 8 meses) del extracto de Psidium cattleyanum Sabine (Myrtaceae) en el perfil de la expresión génica en hipocampo de ratones idosos (Swiss). Después de 8 meses de suplementacion, no se detectaron efectos tóxicos en los animales tratados con relación al grupo control. Los genes con expresión diferencial incluyen, genes que codifican proteínas relacionadas con procesos de señalización, transcripción, metabolismo, así como genes con función desconocida. Los resultados demuestran la importancia de los microarray como herramienta para el estudio del mecanismo de acción de los compuestos fitoquímicos

Large expert-curated database for benchmarking document similarity detection in biomedical literature search

Document recommendation systems for locating relevant literature have mostly relied on methods developed a decade ago. This is largely due to the lack of a large offline gold-standard benchmark of relevant documents that cover a variety of research fields such that newly developed literature search techniques can be compared, improved and translated into practice. To overcome this bottleneck, we have established the RElevant LIterature SearcH consortium consisting of more than 1500 scientists from 84 countries, who have collectively annotated the relevance of over 180 000 PubMed-listed articles with regard to their respective seed (input) article/s. The majority of annotations were contributed by highly experienced, original authors of the seed articles. The collected data cover 76% of all unique PubMed Medical Subject Headings descriptors. No systematic biases were observed across different experience levels, research fields or time spent on annotations. More importantly, annotations of the same document pairs contributed by different scientists were highly concordant. We further show that the three representative baseline methods used to generate recommended articles for evaluation (Okapi Best Matching 25, Term Frequency-Inverse Document Frequency and PubMed Related Articles) had similar overall performances. Additionally, we found that these methods each tend to produce distinct collections of recommended articles, suggesting that a hybrid method may be required to completely capture all relevant articles. The established database server located at https://relishdb.ict.griffith.edu.au is freely available for the downloading of annotation data and the blind testing of new methods. We expect that this benchmark will be useful for stimulating the development of new powerful techniques for title and title/abstract-based search engines for relevant articles in biomedical research.Peer reviewe

All the King’s Women: Female Agency in the Political Comedias of Juan Ruiz de Alarcón

In his political comedias, seventeenth-century Novohispanic playwright Juan Ruiz de Alarcón shows as much interest in criticizing the ethical behavior of male characters as he does in representing violence against the female ones. This intersection of gender and political power is analyzed in the texts from a gender-perspective and supported by recent historiography on the political agency of royal women during the Spanish Golden Age. Despite the aggressions against them, Alarcón’s female characters consistently act according to reason, morality, and law. Furthermore, the decisions that restore the order lost to the intricate movements of the plots are not exclusively proposed or executed by the male characters, but usually foreseen or directly suggested by the female ones. In appropriating the functions reserved for a few privileged men, these women propose an alternative mode of government that challenges the traditional relationships between gender roles and political participation as understood in imperial Spain

Implementing a medical student interpreter training program as a strategy to developing humanism

Abstract Background Humanistic care in medicine has shown to improve healthcare outcomes. Language barriers are a significant obstacle to humanistic care, and trained medical interpreters have demonstrated to effectively bridge the gap for the vulnerable limited English proficiency (LEP) patient population. One way in which medical schools can train more humanistic physicians and provide language access is through the implementation of programs to train bilingual medical students as medical interpreters. The purpose of this prospective study was to evaluate whether such training had an impact on bilingual medical student’s interpretation skills and humanistic traits. Methods Between 2015 and 2017, whole-day (~ 8 h) workshops on medical interpretation were offered periodically to 80 bilingual medical students at the Penn State College of Medicine. Students completed a series of questionnaires before and after the training that assessed the program’s effectiveness and its overall impact on interpretation skills and humanistic traits. Students also had the opportunity to become certified medical interpreters. Results The 80 student participants were first- to third- year medical students representing 21 languages. Following training, most students felt more confident interpreting (98%) and more empathetic towards LEP patients (87.5%). Students’ scores in the multiple-choice questions about medical interpretation/role of the interpreter were also significantly improved (Chi-Square test, p < 0.05). All students who decided to take the exam were able to successfully become certified interpreters. Ninety-two percent of participants reported they would recommend the program and would be willing to serve as a future “coaches” for interpreter training workshops delivered to peer students. Conclusions Our program was successful in increasing self-reported measures of empathy and humanism in medical students. Our data suggests that implementation of medical interpreter training programs can be a successful strategy to develop of humanism in medical students, and aid in the development of sustainable language access for LEP patients

Additional file 2: of Implementing a medical student interpreter training program as a strategy to developing humanism

Anonymous survey (“Part 2 post”) administered to workshop participants to obtain post-workshop feedback about the program and their self-rated confidence about their interpretation abilities. (PDF 38 kb

Additional file 1: of Implementing a medical student interpreter training program as a strategy to developing humanism

Anonymous pre-workshop surveys (“Part 1”, “Part 2 pre”, and “Part 3”), and post-workshop surveys (“Part 1” and “Part 3”) administered to participants to obtain information about the interpreation process knowledge, cultural competencies, language skills and cultural background . (PDF 55 kb

Large expert-curated database for benchmarking document similarity detection in biomedical literature search

Document recommendation systems for locating relevant literature have mostly relied on methods developed a decade ago. This is largely due to the lack of a large offline gold-standard benchmark of relevant documents that cover a variety of research fields such that newly developed literature search techniques can be compared, improved and translated into practice. To overcome this bottleneck, we have established the RElevant LIterature SearcH consortium consisting of more than 1500 scientists from 84 countries, who have collectively annotated the relevance of over 180 000 PubMed-listed articles with regard to their respective seed (input) article/s. The majority of annotations were contributed by highly experienced, original authors of the seed articles. The collected data cover 76% of all unique PubMed Medical Subject Headings descriptors. No systematic biases were observed across different experience levels, research fields or time spent on annotations. More importantly, annotations of the same document pairs contributed by different scientists were highly concordant. We further show that the three representative baseline methods used to generate recommended articles for evaluation (Okapi Best Matching 25, Term Frequency-Inverse Document Frequency and PubMed Related Articles) had similar overall performances. Additionally, we found that these methods each tend to produce distinct collections of recommended articles, suggesting that a hybrid method may be required to completely capture all relevant articles. The established database server located at https://relishdb.ict.griffith.edu.au is freely available for the downloading of annotation data and the blind testing of new methods. We expect that this benchmark will be useful for stimulating the development of new powerful techniques for title and title/abstract-based search engines for relevant articles in biomedical science. © The Author(s) 2019. Published by Oxford University Press