Real-time Monitoring for the Next Core-Collapse Supernova in JUNO

Core-collapse supernova (CCSN) is one of the most energetic astrophysical events in the Universe. The early and prompt detection of neutrinos before (pre-SN) and during the SN burst is a unique opportunity to realize the multi-messenger observation of the CCSN events. In this work, we describe the monitoring concept and present the sensitivity of the system to the pre-SN and SN neutrinos at the Jiangmen Underground Neutrino Observatory (JUNO), which is a 20 kton liquid scintillator detector under construction in South China. The real-time monitoring system is designed with both the prompt monitors on the electronic board and online monitors at the data acquisition stage, in order to ensure both the alert speed and alert coverage of progenitor stars. By assuming a false alert rate of 1 per year, this monitoring system can be sensitive to the pre-SN neutrinos up to the distance of about 1.6 (0.9) kpc and SN neutrinos up to about 370 (360) kpc for a progenitor mass of 30$M_{\odot}$ for the case of normal (inverted) mass ordering. The pointing ability of the CCSN is evaluated by using the accumulated event anisotropy of the inverse beta decay interactions from pre-SN or SN neutrinos, which, along with the early alert, can play important roles for the followup multi-messenger observations of the next Galactic or nearby extragalactic CCSN.Comment: 24 pages, 9 figure

Large expert-curated database for benchmarking document similarity detection in biomedical literature search

Document recommendation systems for locating relevant literature have mostly relied on methods developed a decade ago. This is largely due to the lack of a large offline gold-standard benchmark of relevant documents that cover a variety of research fields such that newly developed literature search techniques can be compared, improved and translated into practice. To overcome this bottleneck, we have established the RElevant LIterature SearcH consortium consisting of more than 1500 scientists from 84 countries, who have collectively annotated the relevance of over 180 000 PubMed-listed articles with regard to their respective seed (input) article/s. The majority of annotations were contributed by highly experienced, original authors of the seed articles. The collected data cover 76% of all unique PubMed Medical Subject Headings descriptors. No systematic biases were observed across different experience levels, research fields or time spent on annotations. More importantly, annotations of the same document pairs contributed by different scientists were highly concordant. We further show that the three representative baseline methods used to generate recommended articles for evaluation (Okapi Best Matching 25, Term Frequency-Inverse Document Frequency and PubMed Related Articles) had similar overall performances. Additionally, we found that these methods each tend to produce distinct collections of recommended articles, suggesting that a hybrid method may be required to completely capture all relevant articles. The established database server located at https://relishdb.ict.griffith.edu.au is freely available for the downloading of annotation data and the blind testing of new methods. We expect that this benchmark will be useful for stimulating the development of new powerful techniques for title and title/abstract-based search engines for relevant articles in biomedical research.Peer reviewe

Pooled analysis of WHO Surgical Safety Checklist use and mortality after emergency laparotomy

Background The World Health Organization (WHO) Surgical Safety Checklist has fostered safe practice for 10 years, yet its place in emergency surgery has not been assessed on a global scale. The aim of this study was to evaluate reported checklist use in emergency settings and examine the relationship with perioperative mortality in patients who had emergency laparotomy. Methods In two multinational cohort studies, adults undergoing emergency laparotomy were compared with those having elective gastrointestinal surgery. Relationships between reported checklist use and mortality were determined using multivariable logistic regression and bootstrapped simulation. Results Of 12 296 patients included from 76 countries, 4843 underwent emergency laparotomy. After adjusting for patient and disease factors, checklist use before emergency laparotomy was more common in countries with a high Human Development Index (HDI) (2455 of 2741, 89.6 per cent) compared with that in countries with a middle (753 of 1242, 60.6 per cent; odds ratio (OR) 0.17, 95 per cent c.i. 0.14 to 0.21, P <0001) or low (363 of 860, 422 per cent; OR 008, 007 to 010, P <0.001) HDI. Checklist use was less common in elective surgery than for emergency laparotomy in high-HDI countries (risk difference -94 (95 per cent c.i. -11.9 to -6.9) per cent; P <0001), but the relationship was reversed in low-HDI countries (+121 (+7.0 to +173) per cent; P <0001). In multivariable models, checklist use was associated with a lower 30-day perioperative mortality (OR 0.60, 0.50 to 073; P <0.001). The greatest absolute benefit was seen for emergency surgery in low- and middle-HDI countries. Conclusion Checklist use in emergency laparotomy was associated with a significantly lower perioperative mortality rate. Checklist use in low-HDI countries was half that in high-HDI countries.Peer reviewe

Global variation in anastomosis and end colostomy formation following left-sided colorectal resection

Background End colostomy rates following colorectal resection vary across institutions in high-income settings, being influenced by patient, disease, surgeon and system factors. This study aimed to assess global variation in end colostomy rates after left-sided colorectal resection. Methods This study comprised an analysis of GlobalSurg-1 and -2 international, prospective, observational cohort studies (2014, 2016), including consecutive adult patients undergoing elective or emergency left-sided colorectal resection within discrete 2-week windows. Countries were grouped into high-, middle- and low-income tertiles according to the United Nations Human Development Index (HDI). Factors associated with colostomy formation versus primary anastomosis were explored using a multilevel, multivariable logistic regression model. Results In total, 1635 patients from 242 hospitals in 57 countries undergoing left-sided colorectal resection were included: 113 (6·9 per cent) from low-HDI, 254 (15·5 per cent) from middle-HDI and 1268 (77·6 per cent) from high-HDI countries. There was a higher proportion of patients with perforated disease (57·5, 40·9 and 35·4 per cent; P < 0·001) and subsequent use of end colostomy (52·2, 24·8 and 18·9 per cent; P < 0·001) in low- compared with middle- and high-HDI settings. The association with colostomy use in low-HDI settings persisted (odds ratio (OR) 3·20, 95 per cent c.i. 1·35 to 7·57; P = 0·008) after risk adjustment for malignant disease (OR 2·34, 1·65 to 3·32; P < 0·001), emergency surgery (OR 4·08, 2·73 to 6·10; P < 0·001), time to operation at least 48 h (OR 1·99, 1·28 to 3·09; P = 0·002) and disease perforation (OR 4·00, 2·81 to 5·69; P < 0·001). Conclusion Global differences existed in the proportion of patients receiving end stomas after left-sided colorectal resection based on income, which went beyond case mix alone

ISO 9001 International Standard, a Tool to Enhance Data Quality in Durable Socio-Technical Systems

International audienceThe quality of data is recognized to be a key issue for the assets management in enterprises as data is the foundation of any decision making process. Recent research work has established that the quality of data is highly dependent on the knowledge one has on the socio-technical system being considered. Three modes of knowledge have been identified: knowing what, knowing how and knowing why. In this paper we focus on how to manage these modes of knowledge in durable socio-technical systems to enhance the data quality face to technological progress and employees turnover. We believe that an organization based on ISO 9001 international standard can provide a valuable framework to provide the data quality needed to an efficient decision making process. This framework has been applied to design the data quality management system within a high education socio-technical system. The most important benefits that have been noticed are: 1) a shared vision on the external clients of the system with a positive impact on the definition of the strategy and the objectives of the system and 2) a deep understanding of the data client-supplier relationship inside the socio-technical system. A direct consequence of these achievements was the increasing knowledge on “know-what” data to collect, “know-why” to collect that data and “know-how” to collect it

Monte Carlo based Petri net simulation for maintenance strategies assessment in series-parallel-series multi-physic systems

International audienceThe authors propose a methodology to assess the effectiveness of a maintenance strategy on the availability of a serial-parallel multi-physic system, using Monte Carlo simulation embedded in a Petri net model. The systems are composed of heterogenous components that are characterized by specific degradations and failure mechanisms. Building an effective maintenance strategy to improve the availability of such a system requires to monitoring the degradation of each component. We assume that each component is subject to stochastic degradations. Also, we consider that each component might have three health status, according to degradation thresholds, function of the component reliability: “healthy”, “degraded” and “failed”. The health condition of the overall system relies on the health status of each component. A model for tracking the status of each component has been worked out using a colored stochastic Petri net (CSPN). Each health status is modeled by a place within the CSPN model, where each component is modeled by a colored token. The degradation of each component of the system is evaluated based on the Monte Carlo simulation technique. Transition firing regarding a given color model the evolution of the associated component from a health condition to another due to the degradation mechanism or to a maintenance action aimed to restore partially or totally its performance. However, the degradation of each component does not have the same influence on the performance of the overall system. Operational performance indicators are introduced to quantify the influence of each component on the performance of the entire system. Furthermore, maintenance actions are defined taking into account the degradation level of each component, the influence that each component has on the performance of the system and the available repairman. The effectiveness of the maintenance strategy on the system availability is evaluated through simulation

Simulation-based discrete optimization of stochastic discrete event systems subject to non closed form constraints

International audienceThis technical note addresses the discrete optimization of stochastic discrete event systems for which both the performance function and the constraint function are not known but can be evaluated by simulation and the solution space is either finite or unbounded. Our method is based on random search in a neighborhood structure called the most promising area proposed in [7] and a moving observation area. The simulation budget is allocated dynamically to promising solutions. Simulation-based constraints are taken into account in an augmented performance function via an increasing penalty factor. We prove that under some assumptions, the algorithm converges with probability 1 to a set of true local optimal solutions. These assumptions are restrictive and difficult to verify but we hope that the encouraging numerical results would motivate future research exploiting ideas of this technical note

On the Supervisory Control of Marked Graphs

International audienc