Tradução do Valve Handbook for New Employees como texto de divulgação técnica

Monografia (graduação)—Universidade de Brasília, Instituto de Letras, Departamento de Línguas Estrangeiras e Tradução, Curso de Letras – Tradução, 2014.O presente trabalho compreende uma possibilidade de traducao para portugues do Handbook for New Employees da companhia de softwares Valve. O manual esta voltado para instrucao de como o novo funcionario pode integrar-se a uma estrutura de trabalho heterodoxa. Por outro lado, a proposta de traducao tem como publico-alvo aqueles que querem conhecer a estrutura da companhia, lidando com pouca terminologia. Comparado a outros manuais para funcionarios, o Handbook apresenta caracteristicas unicas quanto a linguagem e abordagem dos topicos. A discussao teorica do trabalho concentra-se na distincao dos textos tecnicos, com destaque para a traducao desses em textos de divulgacao técnica por meio dos arcaboucos teoricos da Natureza da Tradução apresentada por Eugene Nida. ___________________________________________________________________________ ABSTRACTThis paper comprehends a Portuguese translation possibility for Valve Corporation’s Handbook for New Employees. The handbook at issue is about instructing new employees on how they can integrate themselves into an unconventional workplace. On the other hand, the proposed translation is intended to those who want to learn about the company structure, dealing less with terminology. Compared to other employee handbooks, Valve’s presents unique characteristics regarding language and approach to topics. The theoretical discussion of this paper concentrates on the distinctiveness of technical texts, with emphasis on translating them into technical disclosure texts by means of Eugene Nida’s The Nature of Translating

EFECTO DE TRES FRECUENCIAS DE ALIMENTACIÓN EN EL CRECIMIENTO, UTILIZACIÓN DE ALIMENTO Y SOBREVIVENCIA DE JUVENILES DE DONCELLA Pseudoplatystoma fasciatum (Linnaeus, 1766).

The tiger shovelnose catfish Pseudoplatystoma fasciatum (Linnaeus, 1766), a species widely distributed in South America, is a fish that due to its high-quality meat and fast growth, has been arising the interest of fish farmers, specially in countries like Brazil, Colombia, and Peru. The Peruvian governmental agency known as PROMPERU, has been looking for new international markets for this fish overseas, and at the same time linking efforts with other Peruvian organisms in order to develop strategies and studies that can lead to the establishment of a sustainable meat production of tiger shovelnose catfish, for international trade. One of these institutions is the Peruvian Amazon Research Institute–IIAP, which is developing a series of studies in order to generate culture technology for this catfish. The main goal of this study was to evaluate the effects of three feeding frequencies (FA2, FA4, and FA6) on the growth, feed utilization and survival of tiger shovelnose catfish (P. fasciatum) juveniles fed a pelleted diet (42% CP) during 45 days. At the end of the study, no significant differences (P>0.05) in fish growth, feed utilization and survival levels were recorded as result of the three feeding frequencies (2, 4 and 6 times/day) evaluated. To sum up, tiger shovelnose catfish juveniles of around 20 g of mean body weight would only need to be fed twice per day, which will allow the fish farmers to obtain an adequate fish yield performance with minimal work requirement.La doncella Pseudoplatystoma fasciatum (Linnaeus, 1766), especie que tiene una amplia distribución en Sudamérica, es un pez, que por la calidad de su carne y su rápido crecimiento viene despertando el interés del sector acuícola, principalmente en países como Brasil, Colombia y el Perú. La agencia gubernamental peruana PROMPERU, viene buscando mercados para la carne de este pez y al mismo tiempo articulando con otros actores, el desarrollo de planes e investigaciones para el establecimiento de una oferta exportable de su filete. Uno de estos actores, es el Instituto de Investigaciones de la Amazonía Peruana–IIAP, institución que viene desarrollando una serie de estudios que lleven a la generación de tecnologías para el cultivo de la doncella. El objetivo del presente trabajo fue evaluar los posibles efectos de tres frecuencias de alimentación (FA2, FA4 y FA6) sobre el crecimiento, utilización del alimento y sobrevivencia de juveniles de doncella (P. fasciatum) alimentados con una dieta peletizada (42% PB) durante 45 días. Al final del estudio, no se registraron diferencias significativas (P>0.05) en los índices de crecimiento, utilización de alimento, ni en los niveles de sobrevivencia de los peces como efecto de la aplicación de las tres frecuencias de alimentación (2, 4 y 6 veces/día). En conclusión, juveniles de doncella, de 20 g de peso promedio, sólo necesitarían ser alimentados dos veces al día, lo que permitirá al acuicultor obtener un adecuado rendimiento productivo de los peces, con un mínimo requerimiento de mano de obra

Association Between Preexisting Versus Newly Identified Atrial Fibrillation and Outcomes of Patients With Acute Pulmonary Embolism

Background Atrial fibrillation (AF) may exist before or occur early in the course of pulmonary embolism (PE). We determined the PE outcomes based on the presence and timing of AF. Methods and Results Using the data from a multicenter PE registry, we identified 3 groups: (1) those with preexisting AF, (2) patients with new AF within 2 days from acute PE (incident AF), and (3) patients without AF. We assessed the 90-day and 1-year risk of mortality and stroke in patients with AF, compared with those without AF (reference group). Among 16 497 patients with PE, 792 had preexisting AF. These patients had increased odds of 90-day all-cause (odds ratio [OR], 2.81; 95% CI, 2.33-3.38) and PE-related mortality (OR, 2.38; 95% CI, 1.37-4.14) and increased 1-year hazard for ischemic stroke (hazard ratio, 5.48; 95% CI, 3.10-9.69) compared with those without AF. After multivariable adjustment, preexisting AF was associated with significantly increased odds of all-cause mortality (OR, 1.91; 95% CI, 1.57-2.32) but not PE-related mortality (OR, 1.50; 95% CI, 0.85-2.66). Among 16 497 patients with PE, 445 developed new incident AF within 2 days of acute PE. Incident AF was associated with increased odds of 90-day all-cause (OR, 2.28; 95% CI, 1.75-2.97) and PE-related (OR, 3.64; 95% CI, 2.01-6.59) mortality but not stroke. Findings were similar in multivariable analyses. Conclusions In patients with acute symptomatic PE, both preexisting AF and incident AF predict adverse clinical outcomes. The type of adverse outcomes may differ depending on the timing of AF onset.info:eu-repo/semantics/publishedVersio

Evolving trends in the management of acute appendicitis during COVID-19 waves. The ACIE appy II study

Background: In 2020, ACIE Appy study showed that COVID-19 pandemic heavily affected the management of patients with acute appendicitis (AA) worldwide, with an increased rate of non-operative management (NOM) strategies and a trend toward open surgery due to concern of virus transmission by laparoscopy and controversial recommendations on this issue. The aim of this study was to survey again the same group of surgeons to assess if any difference in management attitudes of AA had occurred in the later stages of the outbreak. Methods: From August 15 to September 30, 2021, an online questionnaire was sent to all 709 participants of the ACIE Appy study. The questionnaire included questions on personal protective equipment (PPE), local policies and screening for SARS-CoV-2 infection, NOM, surgical approach and disease presentations in 2021. The results were compared with the results from the previous study. Results: A total of 476 answers were collected (response rate 67.1%). Screening policies were significatively improved with most patients screened regardless of symptoms (89.5% vs. 37.4%) with PCR and antigenic test as the preferred test (74.1% vs. 26.3%). More patients tested positive before surgery and commercial systems were the preferred ones to filter smoke plumes during laparoscopy. Laparoscopic appendicectomy was the first option in the treatment of AA, with a declined use of NOM. Conclusion: Management of AA has improved in the last waves of pandemic. Increased evidence regarding SARS-COV-2 infection along with a timely healthcare systems response has been translated into tailored attitudes and a better care for patients with AA worldwide

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

In 2008 we published the first set of guidelines for standardizing research in autophagy. Since then, research on this topic has continued to accelerate, and many new scientists have entered the field. Our knowledge base and relevant new technologies have also been expanding. Accordingly, it is important to update these guidelines for monitoring autophagy in different organisms. Various reviews have described the range of assays that have been used for this purpose. Nevertheless, there continues to be confusion regarding acceptable methods to measure autophagy, especially in multicellular eukaryotes. For example, a key point that needs to be emphasized is that there is a difference between measurements that monitor the numbers or volume of autophagic elements (e.g., autophagosomes or autolysosomes) at any stage of the autophagic process versus those that measure fl ux through the autophagy pathway (i.e., the complete process including the amount and rate of cargo sequestered and degraded). In particular, a block in macroautophagy that results in autophagosome accumulation must be differentiated from stimuli that increase autophagic activity, defi ned as increased autophagy induction coupled with increased delivery to, and degradation within, lysosomes (inmost higher eukaryotes and some protists such as Dictyostelium ) or the vacuole (in plants and fungi). In other words, it is especially important that investigators new to the fi eld understand that the appearance of more autophagosomes does not necessarily equate with more autophagy. In fact, in many cases, autophagosomes accumulate because of a block in trafficking to lysosomes without a concomitant change in autophagosome biogenesis, whereas an increase in autolysosomes may reflect a reduction in degradative activity. It is worth emphasizing here that lysosomal digestion is a stage of autophagy and evaluating its competence is a crucial part of the evaluation of autophagic flux, or complete autophagy. Here, we present a set of guidelines for the selection and interpretation of methods for use by investigators who aim to examine macroautophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes. These guidelines are not meant to be a formulaic set of rules, because the appropriate assays depend in part on the question being asked and the system being used. In addition, we emphasize that no individual assay is guaranteed to be the most appropriate one in every situation, and we strongly recommend the use of multiple assays to monitor autophagy. Along these lines, because of the potential for pleiotropic effects due to blocking autophagy through genetic manipulation it is imperative to delete or knock down more than one autophagy-related gene. In addition, some individual Atg proteins, or groups of proteins, are involved in other cellular pathways so not all Atg proteins can be used as a specific marker for an autophagic process. In these guidelines, we consider these various methods of assessing autophagy and what information can, or cannot, be obtained from them. Finally, by discussing the merits and limits of particular autophagy assays, we hope to encourage technical innovation in the field

Prevalence, associated factors and outcomes of pressure injuries in adult intensive care unit patients: the DecubICUs study

Funder: European Society of Intensive Care Medicine; doi: http://dx.doi.org/10.13039/501100013347Funder: Flemish Society for Critical Care NursesAbstract: Purpose: Intensive care unit (ICU) patients are particularly susceptible to developing pressure injuries. Epidemiologic data is however unavailable. We aimed to provide an international picture of the extent of pressure injuries and factors associated with ICU-acquired pressure injuries in adult ICU patients. Methods: International 1-day point-prevalence study; follow-up for outcome assessment until hospital discharge (maximum 12 weeks). Factors associated with ICU-acquired pressure injury and hospital mortality were assessed by generalised linear mixed-effects regression analysis. Results: Data from 13,254 patients in 1117 ICUs (90 countries) revealed 6747 pressure injuries; 3997 (59.2%) were ICU-acquired. Overall prevalence was 26.6% (95% confidence interval [CI] 25.9–27.3). ICU-acquired prevalence was 16.2% (95% CI 15.6–16.8). Sacrum (37%) and heels (19.5%) were most affected. Factors independently associated with ICU-acquired pressure injuries were older age, male sex, being underweight, emergency surgery, higher Simplified Acute Physiology Score II, Braden score 3 days, comorbidities (chronic obstructive pulmonary disease, immunodeficiency), organ support (renal replacement, mechanical ventilation on ICU admission), and being in a low or lower-middle income-economy. Gradually increasing associations with mortality were identified for increasing severity of pressure injury: stage I (odds ratio [OR] 1.5; 95% CI 1.2–1.8), stage II (OR 1.6; 95% CI 1.4–1.9), and stage III or worse (OR 2.8; 95% CI 2.3–3.3). Conclusion: Pressure injuries are common in adult ICU patients. ICU-acquired pressure injuries are associated with mainly intrinsic factors and mortality. Optimal care standards, increased awareness, appropriate resource allocation, and further research into optimal prevention are pivotal to tackle this important patient safety threat

Correction to: Prevalence, associated factors and outcomes of pressure injuries in adult intensive care unit patients: the DecubICUs study

The original version of this article unfortunately contained a mistake

Prevalence, associated factors and outcomes of pressure injuries in adult intensive care unit patients: the DecubICUs study

Funder: European Society of Intensive Care Medicine; doi: http://dx.doi.org/10.13039/501100013347Funder: Flemish Society for Critical Care NursesAbstract: Purpose: Intensive care unit (ICU) patients are particularly susceptible to developing pressure injuries. Epidemiologic data is however unavailable. We aimed to provide an international picture of the extent of pressure injuries and factors associated with ICU-acquired pressure injuries in adult ICU patients. Methods: International 1-day point-prevalence study; follow-up for outcome assessment until hospital discharge (maximum 12 weeks). Factors associated with ICU-acquired pressure injury and hospital mortality were assessed by generalised linear mixed-effects regression analysis. Results: Data from 13,254 patients in 1117 ICUs (90 countries) revealed 6747 pressure injuries; 3997 (59.2%) were ICU-acquired. Overall prevalence was 26.6% (95% confidence interval [CI] 25.9–27.3). ICU-acquired prevalence was 16.2% (95% CI 15.6–16.8). Sacrum (37%) and heels (19.5%) were most affected. Factors independently associated with ICU-acquired pressure injuries were older age, male sex, being underweight, emergency surgery, higher Simplified Acute Physiology Score II, Braden score 3 days, comorbidities (chronic obstructive pulmonary disease, immunodeficiency), organ support (renal replacement, mechanical ventilation on ICU admission), and being in a low or lower-middle income-economy. Gradually increasing associations with mortality were identified for increasing severity of pressure injury: stage I (odds ratio [OR] 1.5; 95% CI 1.2–1.8), stage II (OR 1.6; 95% CI 1.4–1.9), and stage III or worse (OR 2.8; 95% CI 2.3–3.3). Conclusion: Pressure injuries are common in adult ICU patients. ICU-acquired pressure injuries are associated with mainly intrinsic factors and mortality. Optimal care standards, increased awareness, appropriate resource allocation, and further research into optimal prevention are pivotal to tackle this important patient safety threat