111 research outputs found
Ribosomal oxygenases are structurally conserved from prokaryotes to humans
- Author
- A SzilĂĄgyi
- Aidan J. Doherty
- AJ McCoy
- AT BrĂŒnger
- C Loenarz
- CA Regni
- CG Yang
- Chia-hua Ho
- Christopher J. Schofield
- CJ Webby
- Claire Phillips
- CS Bond
- DE Lancaster
- E van den Born
- EA Groisman
- EC Woon
- Ewa S. Pilka
- Frank von Delft
- G Bricogne
- Gavin C. Fox
- GM Sheldrick
- GN Murshudov
- Ian J. Clifton
- IJ Clifton
- J Henri
- JM Elkins
- Joao R. C. Muniz
- JP Abrahams
- JR Horton
- K Cowtan
- Kathryn L. Kavanagh
- KM Sinha
- L Holm
- L Kruidenier
- LJ Walport
- LM Hoffart
- LM Iyer
- M Kato
- M Teichmann
- M Yang
- M Yang
- MA Larkin
- MA McDonough
- MD Winn
- ME Cockman
- Melanie Vollmar
- Michael A. McDonough
- MV Han
- N Yosef
- Nadia J. Kershaw
- Nigel C. Brissett
- OS Smart
- P Emsley
- PA Del Rizzo
- PD Adams
- R Chowdhury
- R Miller
- Rasheduzzaman Chowdhury
- RJ Klose
- Rok Sekirnik
- RP Hausinger
- S Wang
- SA Guerrero
- SD Wong
- SS Ng
- Stanley S. Ng
- T Feng
- T Sengoku
- TC Terwilliger
- TM Schmeing
- Tobias Krojer
- Udo Oppermann
- VB Chen
- W Aik
- W Ge
- Wei Ge
- WG Kaelin Jr
- Y Fu
- Y Tao
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2014
- Field of study
2-Oxoglutarate (2OG)-dependent oxygenases have important roles in the regulation of gene expression via demethylation of N-methylated chromatin components1,2 and in the hydroxylation of transcription factors3 and splicing factor proteins4. Recently, 2OG-dependent oxygenases that catalyse hydroxylation of transfer RNA5,6,7 and ribosomal proteins8 have been shown to be important in translation relating to cellular growth, TH17-cell differentiation and translational accuracy9,10,11,12. The finding that ribosomal oxygenases (ROXs) occur in organisms ranging from prokaryotes to humans8 raises questions as to their structural and evolutionary relationships. In Escherichia coli, YcfD catalyses arginine hydroxylation in the ribosomal protein L16; in humans, MYC-induced nuclear antigen (MINA53; also known as MINA) and nucleolar protein 66 (NO66) catalyse histidine hydroxylation in the ribosomal proteins RPL27A and RPL8, respectively. The functional assignments of ROXs open therapeutic possibilities via either ROX inhibition or targeting of differentially modified ribosomes. Despite differences in the residue and protein selectivities of prokaryotic and eukaryotic ROXs, comparison of the crystal structures of E. coli YcfD and Rhodothermus marinus YcfD with those of human MINA53 and NO66 reveals highly conserved folds and novel dimerization modes defining a new structural subfamily of 2OG-dependent oxygenases. ROX structures with and without their substrates support their functional assignments as hydroxylases but not demethylases, and reveal how the subfamily has evolved to catalyse the hydroxylation of different residue side chains of ribosomal proteins. Comparison of ROX crystal structures with those of other JmjC-domain-containing hydroxylases, including the hypoxia-inducible factor asparaginyl hydroxylase FIH and histone NΔ-methyl lysine demethylases, identifies branch points in 2OG-dependent oxygenase evolution and distinguishes between JmjC-containing hydroxylases and demethylases catalysing modifications of translational and transcriptional machinery. The structures reveal that new protein hydroxylation activities can evolve by changing the coordination position from which the iron-bound substrate-oxidizing species reacts. This coordination flexibility has probably contributed to the evolution of the wide range of reactions catalysed by oxygenases
How a Diverse Research Ecosystem Has Generated New Rehabilitation Technologies: Review of NIDILRRâs Rehabilitation Engineering Research Centers
- Author
- A Arnoldussen
- A Hansen
- A Hansen
- A Hansen
- A Hansen
- A Hansen
- A Hansen
- A Hansen
- A Hansen
- A Hansen
- A Hansen
- A Heinemann
- A Heinemann
- A Heinemann
- A Steinfeld
- A Steinfeld
- A Steinfeld
- AA Rizzo
- Aaron Steinfeld
- AH Hansen
- AH Hansen
- AH Hansen
- AH Hansen
- AH Hansen
- AH Hansen
- AH Hansen
- AH Hansen
- AH Hansen
- AH Hansen
- AH Hansen
- AH Hansen
- AH Hansen
- AH Hansen
- AH Hansen
- AH Hansen
- AH Hansen
- AH Hansen
- AH Hansen
- AW Heinemann
- AW Heinemann
- B French
- B Kemp
- B Lange
- B Parmanto
- BE Dicianno
- BJ Hafner
- BJ Kemp
- BL Faett
- BL Plassman
- BS Lange
- C Bodine
- C DâSouza
- C Experience
- C Gao
- C RearLab
- C Scherer
- Carolee Winstein
- Cathy Bodine
- CC Collins
- CC Wang
- CC Wang
- Center for Inclusive Design and Environmental Access
- CW Heckathorne
- CW Heckathorne
- D Beukelman
- D Childress
- DA Hobson
- David Brienza
- David J. Reinkensmeyer
- DD Carroll
- DG Kamper
- DJ Higginbotham
- DJ Reinkensmeyer
- DS Childress
- DS Childress
- DS Childress
- DS Childress
- DS Childress
- DS Childress
- DS Childress
- DS Childress
- DS Childress
- DS Childress
- DS Childress
- DS Childress
- E Boutwell
- E Boutwell
- E Klodd
- E Rimmer Wang
- E Sorci
- E Steinfeld
- E Steinfeld
- E Steinfeld
- E Steinfeld
- E Suma
- E Taub
- EA Biddiss
- EA Finkelstein
- Edmund Durfee
- Edward Steinfeld
- EF LoPresti
- EF LoPresti
- EV Boutwell
- F Harris
- Frank DeRuyter
- G Danford
- G Guarniero
- G Vanderheiden
- G Vanderheiden
- Geoff Fernie
- Gerald F. Harris
- Gregg Vanderheiden
- GW Heath
- H Hoenig
- H Hoenig
- Helena Mitchell
- HM Al-Angari
- IJ Hubbard
- J Hidler
- J Langone
- J Lexell
- J McCarthy
- J Ochoa
- J Patton
- JA Doubler
- JA Doubler
- JA Langlois
- JA Lenker
- JA Lenker
- James H. Rimmer
- James L. Patton
- JAS Arthanat Lenker
- JB Reswick
- JC Stewart
- JC White
- JE Thornton
- JH Rimmer
- JH Rimmer
- JH Rimmer
- JL Kailes
- JL Patton
- John Brabyn
- Jon A. Sanford
- Jordana Maisel
- JR Crawford
- JS Rolock
- JS Rolock
- JW Demers Jutai
- JW Steege
- JW Steege
- JW Steege
- K Christensen
- K Froelich-Grobe
- K Frost
- K Frost
- K Grint
- K Hsieh
- K Konop
- K Tucker
- KA Martin Ginis
- KE Oslakovic
- Kevin Caves
- L Atzori
- L Brinkey
- L OâHare
- L van Roosmalen
- L van Roosmalen
- L van Roosmalen
- Lawrence Schneider
- Levin Sliker
- LI Iezzoni
- LI Iezzoni
- Li-Qun Zhang
- LW Schneider
- M Bednar
- M Buning
- M Buning
- M Buning
- M Daum
- M Domingo
- M Faul
- M Gandy
- M Hall
- M Manary
- M Sam
- M Sam
- M Wehmeyer
- M Wu
- MB Silver-Thorn
- MB Silver-Thorn
- MB Silver-Thorn
- MB Silver-Thorn
- MB Silver-Thorn
- MG Melonis
- Michael McCue
- Michelle A. Meade
- Mike Jones
- MJ Scherer
- ML Boninger
- ML Edwards
- ML Wehmeyer
- MR Meier
- MR Meier
- MR Meier
- MR Meier
- MS Pinzur
- MW Brault
- N Phillips Flemming
- N Sharma
- NA Bayona
- P Heyn
- P Karg
- P Karg
- P Schwejda
- P Welch
- P Williams
- Patricia Karg
- PH Sessoms
- Philip S. Requejo
- Physical Activity Guidelines Advisory Committee
- PS Haubert
- PS Requejo
- Q Weir
- R Proffitt
- R Riener
- R Williams
- RE Cowan
- RE Hanlon
- RF Weir
- RF Weir
- RH Lusher
- RJ Williams
- RM Schein
- RS Gailey
- RS Hostak
- S Arthanat
- S Brandenburg
- S Fatone
- S Fatone
- S Fatone
- S Fatone
- S Fatone
- S Fatone
- S Fuhrman
- S Fuhrman
- S Kwak
- S Landau
- S Sprigle
- S Sprigle
- S Sprigle
- S-Y Chen
- SA Gard
- SA Gard
- SA Gard
- SA Gard
- SA Gard
- SA Gard
- SA Gard
- Sarah Blackstone
- SC Miff
- SE Chen Kim
- SE Sonenblum
- SE Sonenblum
- SE Sonenblum
- SG Fitzgerald
- SJ Housman
- Stefania Fatone
- Stephen Sprigle
- Steven Gard
- TA Kuiken
- TH Liou
- Thomas Corfman
- Todd A. Kuiken
- TR Farrell
- Tracy L. Mitzner
- V Paquet
- VL Roger
- W Abdullah Horner-Johnson
- W Rf
- W Rf
- W Rf
- W Rf
- W Rf
- W Rf
- W Rf
- W. Zev Rymer
- Wendy A. Rogers
- Y Li
- Y Li
- Y Li
- Y Li
- Y Wu
- Y Wu
- Y Wu
- Yue Li
- Z Salipur
- Publication venue
- e-Publications@Marquette
- Publication date
- 01/01/2017
- Field of study
Over 50 million United States citizens (1 in 6 people in the US) have a developmental, acquired, or degenerative disability. The average US citizen can expect to live 20% of his or her life with a disability. Rehabilitation technologies play a major role in improving the quality of life for people with a disability, yet widespread and highly challenging needs remain. Within the US, a major effort aimed at the creation and evaluation of rehabilitation technology has been the Rehabilitation Engineering Research Centers (RERCs) sponsored by the National Institute on Disability, Independent Living, and Rehabilitation Research. As envisioned at their conception by a panel of the National Academy of Science in 1970, these centers were intended to take a âtotal approach to rehabilitationâ, combining medicine, engineering, and related science, to improve the quality of life of individuals with a disability. Here, we review the scope, achievements, and ongoing projects of an unbiased sample of 19 currently active or recently terminated RERCs. Specifically, for each center, we briefly explain the needs it targets, summarize key historical advances, identify emerging innovations, and consider future directions. Our assessment from this review is that the RERC program indeed involves a multidisciplinary approach, with 36 professional fields involved, although 70% of research and development staff are in engineering fields, 23% in clinical fields, and only 7% in basic science fields; significantly, 11% of the professional staff have a disability related to their research. We observe that the RERC program has substantially diversified the scope of its work since the 1970âs, addressing more types of disabilities using more technologies, and, in particular, often now focusing on information technologies. RERC work also now often views users as integrated into an interdependent society through technologies that both people with and without disabilities co-use (such as the internet, wireless communication, and architecture). In addition, RERC research has evolved to view users as able at improving outcomes through learning, exercise, and plasticity (rather than being static), which can be optimally timed. We provide examples of rehabilitation technology innovation produced by the RERCs that illustrate this increasingly diversifying scope and evolving perspective. We conclude by discussing growth opportunities and possible future directions of the RERC program
Host-parasite co-metabolic activation of antitrypanosomal aminomethyl-benzoxaboroles
- Author
- A Adamczyk-Wozniak
- A Jacob
- A Palencia
- A Pappa
- A Ponte-Sucre
- AJ Szempruch
- B Ashibe
- B Langmead
- CL Lobenstein-Verbeek
- CM McEwen Jr
- CS Bond
- CW Tabor
- CZ Ding
- D Cobessi
- D Steverding
- David Horn
- DC Jones
- DC Jones
- E Sonoiki
- E Sonoiki
- F Ronquist
- FL Humoller
- FL Rock
- G Eperon
- G Langer
- GD Bowers
- GN Murshudov
- H Li
- IM Vincent
- Isabel M. Vincent
- J Benach
- J Painter
- JW Lenders
- K Cowtan
- K Nakahara
- K Rutherford
- Ka-Fai Leung
- Kevin D. Read
- L Glover
- L Holm
- LA Kelley
- M Aslett
- M Berube
- MA Keller
- MA Larkin
- Margaret A Phillips
- Mark C. Field
- Martin Zoltner
- MC Field
- MD Winn
- MF Richter
- MG Rossmann
- Michael P. Barrett
- Michael P. Valley
- Michael R. K. Alley
- ML Guther
- N Baker
- N Rooke
- Ning Zhang
- P Babokhov
- P Emsley
- P Spanogiannopoulos
- Paul Scullion
- PR Evans
- QH Hu
- Ricardo C. del Pino
- RK Pandey
- Robert T. Jacobs
- RT Jacobs
- S Alsford
- S Alsford
- S Guindon
- S Panjikar
- S Redmond
- S Trindade
- SC Lovell
- Sebastian Hutchinson
- SG Mungâongâo
- SM Janes
- T Akama
- T Akama
- T Akama
- T Kitamura
- T Kitamura
- TA Pemberton
- V Alterio
- V Briken
- W Kabsch
- W Yuan
- WB Rizzo
- WB Rizzo
- YK Zhang
- Yong-Kang Zhang
- YR Freund
- Yvonne R. Freund
- ZJ Liu
- Publication venue
- 'Public Library of Science (PLoS)'
- Publication date
- 01/02/2018
- Field of study
<div><p>Recent development of benzoxaborole-based chemistry gave rise to a collection of compounds with great potential in targeting diverse infectious diseases, including human African Trypanosomiasis (HAT), a devastating neglected tropical disease. However, further medicinal development is largely restricted by a lack of insight into mechanism of action (MoA) in pathogenic kinetoplastids. We adopted a multidisciplinary approach, combining a high-throughput forward genetic screen with functional group focused chemical biological, structural biology and biochemical analyses, to tackle the complex MoAs of benzoxaboroles in <i>Trypanosoma brucei</i>. We describe an oxidative enzymatic pathway composed of host semicarbazide-sensitive amine oxidase and a trypanosomal aldehyde dehydrogenase TbALDH3. Two sequential reactions through this pathway serve as the key underlying mechanism for activating a series of 4-aminomethylphenoxy-benzoxaboroles as potent trypanocides; the methylamine parental compounds as pro-drugs are transformed first into intermediate aldehyde metabolites, and further into the carboxylate metabolites as effective forms. Moreover, comparative biochemical and crystallographic analyses elucidated the catalytic specificity of TbALDH3 towards the benzaldehyde benzoxaborole metabolites as xenogeneic substrates. Overall, this work proposes a novel drug activation mechanism dependent on both host and parasite metabolism of primary amine containing molecules, which contributes a new perspective to our understanding of the benzoxaborole MoA, and could be further exploited to improve the therapeutic index of antimicrobial compounds.</p></div
Relationship between self-reported dietary intake and physical activity levels among adolescents: The HELENA study
- Author
- BĂ©ghin Laurent
- Cuenca-Garcia Magdalena
- De Bourdeaudhuij Ilse
- De Henauw Stefaan
- Gottrand Frederic
- Hagströmer Maria
- Huybrechts Inge
- Kafatos Anthony
- Le Donne Cinzia
- Montagnese C De Bourdeaudhuij I, De Vriendt T, Matthys C, Vereecken C, de Maeyer M, Ottevaere C, Widhalm K, Phillipp K, Dietrich S, Kubelka B, Boriss-Riedl M, Manios Y, Grammatikaki E, Bouloubasi Z, Louisa Cook T, Eleutheriou S, Consta O, Moschonis G, Katsaroli I, Kraniou G, Papoutsou S, Keke D, Petraki I, Bellou E, Tanagra S, Kallianoti K, Argyropoulou D, Kondaki K, Tsikrika S, Karaiskos C, Meirhaeghe A, Bokor S, Fievet N, Goumidi L, Bergman P, Hagströmer M, Hallström L, Hallberg M, Poortvliet E, WĂ€rnberg J, Rizzo N, Beckman L, Hurtig Wennlöf A, Patterson E, Kwak L, Cernerud L, Tillgren P, Sörensen S, SĂĄnchez-Molero J, PicĂł E, Navarro M, Viadel B, Enrique Carreres J, Merino G, SanjuĂĄn R, Lorente M, JosĂ© SĂĄnchez M, CastellĂł S, Thomas S, Allchurch E, Burguess P, Hall G, Astrom A, SverkĂ©n A, Broberg A, Masson A, Lehoux C, Brabant P, Pate P, Fontaine L, Sebok A, Kuti T, Hegyi A, Maldonado C, Llorente A, GarcĂa E, von Fircks H, Lilja Hallberg M, Messerer M, Larsson M, Fredriksson H, Adamsson V, Börjesson I, FernĂĄndez L, Smillie L, Wills J, MelĂ©ndez A, Benito PJ, CalderĂłn J, JimĂ©nez-PavĂłn D, Valtueña J, Navarro P, Urzanqui A, Albers U, Pedrero R, JosĂ© GĂłmez Lorente J.
- Moreno L Gottrand F, De Henauw S, GonzĂĄlez-Gross M, Gilbert C, Kafatos A, Libersa C, SĂĄnchez J, Kersting M, Sjöstrom M, MolnĂĄr D, Dallongeville J, Hall G, Maes L, Scalfi L, MelĂ©ndez P, Fleta J, CasajĂșs J, RodrĂguez G, TomĂĄs C, Mesana MI, Vicente-RodrĂguez G, Villarroya A, Gil CM, Ara I, Revenga J, Lachen C, FernĂĄndez Alvira J, Bueno G, LĂĄzaro A, Bueno O, LeĂłn JF, Ma Garagorri J, Bueno M, Pablo Rey LĂłpez J, Iglesia I, Velasco P, Bel S, Marcos A, WĂ€rnberg J, Nova E, GĂłmez S, Ligia DĂaz E, Romeo J, Veses A, Angeles Puertollano M, Zapatera B, Pozo T, Beghin L, Libersa C, Iliescu C, Von Berlepsch J, Sichert-Hellert W, Koeppen E, Erhardt E, Csernus K, Török K, Bokor S, Angster M, Nagy E, KovĂĄcs O, RĂ©pasi J, Codrington C, Plada M, Papadaki A, Sarri K, Viskadourou A, Hatzis C, Kiriakakis M, Tsibinos G, Vardavas C, Sbokos M, Protoyeraki E, Fasoulaki M, Stehle P, Pietrzik K, Breidenassel C, Spinneker A, Al-Tahan J, Segoviano M, Berchtold A, Bierschbach C, Blatzheim E, Schuch A, Pickert P, Castillo GarzĂłn MJ, GutiĂ©rrez SĂĄinz Ă, Ortega Porcel FB, Ruiz JR, GarcĂa Artero E, España Romero V, JimĂ©nez-PavĂłn D, SĂĄnchez Muñoz C, Soto V, ChillĂłn P, Heredia JM, Aparicio V, Baena P, Cardia CM, Carbonell A, Arcella D, Catasta G, Censi L, Ciarapica D, Ferrari M, Le Donne C, Leclerq C, MagrĂŹ L, Maiani G, Piccinelli R, Polito A, Spada R, Toti E, Scalfi L
- Moreno Luis A.
- Ottevaere Charlene
- Sjöström Michael
- Vitaglione Paola
- Widhalm Kurt
- Publication venue
- BioMed Central
- Publication date
- 01/01/2011
- Field of study
Background
Evidence suggests possible synergetic effects of multiple lifestyle behaviors on health risks like obesity and other health outcomes. Therefore it is important to investigate associations between dietary and physical activity behavior, the two most important lifestyle behaviors influencing our energy balance and body composition. The objective of the present study is to describe the relationship between energy, nutrient and food intake and the physical activity level among a large group of European adolescents.
Methods
The study comprised a total of 2176 adolescents (46.2% male) from ten European cities participating in the HELENA (Healthy Lifestyle in Europe by Nutrition in Adolescence) study. Dietary intake and physical activity were assessed using validated 24-h dietary recalls and self-reported questionnaires respectively. Analyses of covariance (ANCOVA) were used to compare the energy and nutrient intake and the food consumption between groups of adolescents with different physical activity levels (1st to 3rd tertile).
Results
In both sexes no differences were found in energy intake between the levels of physical activity. The most active males showed a higher intake of polysaccharides, protein, water and vitamin C and a lower intake of saccharides compared to less active males. Females with the highest physical activity level consumed more polysaccharides compared to their least active peers. Male and female adolescents with the highest physical activity levels, consumed more fruit and milk products and less cheese compared to the least active adolescents. The most active males showed higher intakes of vegetables and meat, fish, eggs, meat substitutes and vegetarian products compared to the least active ones. The least active males reported the highest consumption of grain products and potatoes. Within the female group, significantly lower intakes of bread and cereal products and spreads were found for those reporting to spend most time in moderate to vigorous physical activity. The consumption of foods from the remaining food groups, did not differ between the physical activity levels in both sexes.
Conclusion
It can be concluded that dietary habits diverge between adolescents with different self-reported physical activity levels. For some food groups a difference in intake could be found, which were reflected in differences in some nutrient intakes. It can also be concluded that physically active adolescents are not always inclined to eat healthier diets than their less active peers.The HELENA study took place with the financial support of the European Community Sixth RTD Framework Programme (Contract FOOD-CT: 2005-007034). This work was also partially supported by the European Union, in the framework of the Public Health Programme (ALPHA project, Ref: 2006120), the Swedish Council for Working Life and Social Research (FAS), the Spanish Ministry of Education (EX-2007-1124, and EX-2008-0641), and the Spanish Ministry of Health, Maternal, Child Health and Development Network (number RD08/0072) (JPRL, LAM)
Multi-messenger observations of a binary neutron star merger
- Author
- Aab A
- Aartsen MG
- Abbott BP
- Abbott R
- Abbott TD
- Abbott TMC
- Abdalla H
- Abe F
- Abeysekara AU
- Abramo LR
- Abramowski A
- Abreu P
- Acernese F
- Acero F
- Ackermann M
- Ackley K
- Ackley K
- Adams C
- Adams J
- Adams SM
- Adams T
- Addesso P
- Adhikari RX
- Adya VB
- Affeldt C
- Afrough M
- Agarwal B
- Agathos M
- Agatsuma K
- Aggarwal N
- Aglietta M
- Agliozzo C
- Agudo I
- Aguiar OD
- Aguilar JA
- Aharonian F
- Ahlers M
- Ahrens M
- Aiello L
- Ain A
- Ajith P
- Akras S
- Al Samarai I
- Albert A
- Albert A
- Albuquerque IFM
- Albury JM
- Alcaniz JS
- Alexander KD
- Alfaro R
- Alighieri S Di Serego
- Allam S
- Allekotte I
- Allen B
- Allen G
- Allison J
- Allison JR
- Allocca A
- Almela A
- Altin PA
- Altmann D
- Alvarez C
- Alvarez JD
- Alvarez M Dovale
- Alvarez-Muiz J
- Amati L
- Amato A
- An T
- Ananyeva A
- Anastasi GA
- Anchordoqui L
- Andeen K
- Anderson JP
- Anderson SB
- Anderson T
- Anderson WG
- Andrada B
- Andre M
- Andreoni I
- Andreoni I
- Andringa S
- Angelova SV
- Anghinolfi M
- Angner EO
- Angus CR
- Annis J
- Ansseau I
- Antier S
- Anton G
- Antonelli LA
- Antonelli LA
- Anupama GC
- Aoki K
- Aoki W
- Appert S
- Aptekar RL
- Arai K
- Arakawa M
- Aramo C
- Araya MC
- Arcavi I
- Arceo R
- Ardid M
- Areeda JS
- Aresu G
- Argan A
- Argelles C
- Arnaud N
- Array LWA Long Wavelength
- Array MWA Murchison Widefield
- Arrieta M
- Arsene N
- Arteaga-Velzquez JC
- Artola R
- Arun KG
- Asakura Y
- Asaoka Y
- Ascenzi S
- Ashall C
- Ashley MCB
- Ashton G
- Asorey H
- Assis P
- Ast M
- Aston SM
- Astone P
- Atallah DV
- ATLAS
- Atwood WB
- Aubert J-J
- Aubert P
- Aublin J
- Auffenberg J
- Aufmuth P
- Aulbert C
- AultONeal K
- Austin C
- Avgitas T
- Avila G
- Avila-Alvarez A
- Awad A Kuotb
- Axani S
- Baar S
- Babak S
- Bachetti M
- Backes M
- Bacon P
- Bader MKM
- Badescu AM
- Bae S
- Bagherpour H
- Bai X
- Bailes M
- Baker PT
- Balaceanu A
- Balanutsa PV
- Balasubramanian A
- Balbinot E
- Baldaccini F
- Baldini L
- Ballardin G
- Ballmer SW
- Bally J
- Balzer A
- Banagiri S
- Banerji M
- Bannister KW
- Barayoga JC
- Barbarino C
- Barbato F
- Barber AS
- Barbiellini G
- Barbiellini G
- Barclay SE
- Baret B
- Barish BC
- Barker D
- Barkett K
- Barnard M
- Barnes J
- Barone F
- Barr B
- Barrios-Marti J
- Barron JP
- Barsotti L
- Barsuglia M
- Barta D
- Barthelmy SD
- Bartlett J
- Bartos I
- Barway S
- Barway S
- Barwick SW
- Basa S
- Bassiri R
- Basti A
- Bastieri D
- Batch JC
- Bauer FE
- Bauer FE
- Baum V
- Bawaj M
- Bay R
- Bayley JC
- Bazzan M
- Bazzano A
- Bchele M
- Beardmore AP
- Beardsley A
- Beatty JJ
- Becerril A
- Becherini Y
- Bechtol K
- Becker KH
- Becsy B
- Beer C
- Bejger M
- Belahcene I
- Belhorma B
- Bell AS
- Bellazzini R
- Bellido JA
- Bellm E
- Belmont-Moreno E
- Benetti S
- Benkhali F Ait
- Benoit-Levy A
- BenZvi SY
- Berat C
- Berenji B
- Berge D
- Berger BK
- Berger E
- Bergmann G
- Berisso M Gomez
- Berley D
- Bernal A
- Bernardini E
- Bernardini MG
- Bernhard S
- Bernrhr K
- Bero JJ
- Beroiz M
- Berry CPL
- Bersanetti D
- Bertaina ME
- Bertin E
- Bertin V
- Bertolini A
- Berton M
- Bertou X
- Bessell MS
- Besson DZ
- Beswick R
- Betzwieser J
- Bhagwat S
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- Zimnukhov DS
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- Publication venue
- 'American Astronomical Society'
- Publication date
- 01/01/2017
- Field of study
On 2017 August 17 a binary neutron star coalescence candidate (later designated GW170817) with merger time 12:41:04 UTC was observed through gravitational waves by the Advanced LIGO and Advanced Virgo detectors. The Fermi Gamma-ray Burst Monitor independently detected a gamma-ray burst (GRB 170817A) with a time delay of ~1.7 s with respect to the merger time. From the gravitational-wave signal, the source was initially localized to a sky region of 31 deg2 at a luminosity distance of 40+8-8 Mpc and with component masses consistent with neutron stars. The component masses were later measured to be in the range 0.86 to 2.26 Mo. An extensive observing campaign was launched across the electromagnetic spectrum leading to the discovery of a bright optical transient (SSS17a, now with the IAU identification of AT 2017gfo) in NGC 4993 (at ~40 Mpc) less than 11 hours after the merger by the One- Meter, Two Hemisphere (1M2H) team using the 1 m Swope Telescope. The optical transient was independently detected by multiple teams within an hour. Subsequent observations targeted the object and its environment. Early ultraviolet observations revealed a blue transient that faded within 48 hours. Optical and infrared observations showed a redward evolution over ~10 days. Following early non-detections, X-ray and radio emission were discovered at the transientâs position ~9 and ~16 days, respectively, after the merger. Both the X-ray and radio emission likely arise from a physical process that is distinct from the one that generates the UV/optical/near-infrared emission. No ultra-high-energy gamma-rays and no neutrino candidates consistent with the source were found in follow-up searches. These observations support the hypothesis that GW170817 was produced by the merger of two neutron stars in NGC4993 followed by a short gamma-ray burst (GRB 170817A) and a kilonova/macronova powered by the radioactive decay of r-process nuclei synthesized in the ejecta
Search for High-energy Neutrinos from Binary Neutron Star Merger GW170817 with ANTARES, IceCube, and the Pierre Auger Observatory
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- Yodh G.
- Yoshida S.
- Yu Hang
- Yu Haocun
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- Yvert M.
- ZadroĆŒny A.
- Zanolin M.
- Zas E.
- Zavrtanik D.
- Zavrtanik M.
- Zelenova T.
- Zendri J.-P.
- Zepeda A.
- Zertuche L. Magaña
- Zevin M.
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- Zoll M.
- Zong Z.
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- Ălvarez M. Dovale
- Ć mĂda R.
- Ć upĂk J.
- Publication venue
- IOP Publishing
- Publication date
- 21/08/2018
- Field of study
Search for intermediate mass black hole binaries in the first observing run of Advanced LIGO
- Author
- Abbott B.âP.
- Abbott R.
- Abbott T.âD.
- Acernese F.
- Ackley K.
- Adams C.
- Adams T.
- Addesso P.
- Adhikari R.âX.
- Adya V.âB.
- Affeldt C.
- Afrough M.
- Agarwal B.
- Agatsuma K.
- Aggarwal Nancy
- Aguiar O.âD.
- Aiello L.
- Ain A.
- Allen B.
- Allen G.
- Allocca A.
- Almoubayyed H.
- Altin P.âA.
- Amato A.
- Ananyeva A.
- Anderson S.âB.
- Anderson W.âG.
- Antier S.
- Appert S.
- Arai K.
- Araya M.âC.
- Areeda J.âS.
- Arnaud N.
- Arun K.âG.
- Ascenzi S.
- Ashton G.
- Ast M.
- Aston S.âM.
- Astone P.
- Aufmuth P.
- Aulbert C.
- AultONeal K.
- Avila-Alvarez A.
- Babak S.
- Bacon P.
- Bader M.âK.âM.
- Bae S.
- Baker P.âT.
- Baldaccini F.
- Ballardin G.
- Ballmer S.âW.
- Banagiri S.
- Barayoga J.âC.
- Barclay S.âE.
- Barish B.âC.
- Barker D.
- Barone F.
- Barr B.
- Barsotti Lisa
- Barsuglia M.
- Barta D.
- Bartlett J.
- Bartos I.
- Bassiri R.
- Basti A.
- Batch J.âC.
- Baune C.
- Bawaj M.
- Bazzan M.
- Beer C.
- Bejger M.
- Belahcene I.
- Bell A.âS.
- Berger B.âK.
- Bergmann G.
- Berry C.âP.âL.
- Bersanetti D.
- Bertolini A.
- Betzwieser J.
- Bhagwat S.
- Bhandare R.
- Bilenko I.âA.
- Billingsley G.
- Billman C.âR.
- Birch J.
- Birney R.
- Birnholtz O.
- Biscans Sebastien
- Bisht A.
- Bitossi M.
- Biwer C.
- Bizouard M.âA.
- Blackburn J.âK.
- Blackman J.
- Blair C.âD.
- Blair D.âG.
- Blair R.âM.
- Bloemen S.
- Bock O.
- Bode N.
- Boer M.
- Bogaert G.
- Bohe A.
- Bondu F.
- Bonnand R.
- Boom B.âA.
- Bork R.
- Boschi V.
- Bose S.
- Bouffanais Y.
- Bozzi A.
- Bradaschia C.
- Brady P.âR.
- Braginsky V.âB.
- Branchesi M.
- Brau J.âE.
- Briant T.
- Brillet A.
- Brinkmann M.
- Brisson V.
- Brockill P.
- Broida J.âE.
- Brooks A.âF.
- Brown D.âA.
- Brown D.âD.
- Brown N.âM.
- Brunett S.
- Buchanan C.âC.
- Buikema Aaron
- Bulik T.
- Bulten H.âJ.
- Buonanno A.
- Buskulic D.
- Buy C.
- Byer R.âL.
- BĂ©csy B.
- Cabero M.
- Cadonati L.
- Cagnoli G.
- Cahillane C.
- CalderĂłn Bustillo J.
- Callister T.âA.
- Calloni E.
- Camp J.âB.
- Canepa M.
- Canizares P.
- Cannon K.âC.
- Cao H.
- Cao J.
- Capano C.âD.
- Capocasa E.
- Carbognani F.
- Caride S.
- Carney M.âF.
- Casanueva Diaz J.
- Casentini C.
- Caudill S.
- CavagliĂ M.
- Cavalier F.
- Cavalieri R.
- Cella G.
- Cepeda C.âB.
- Cerboni Baiardi L.
- Cerretani G.
- Cesarini E.
- Chamberlin S.âJ.
- Chan M.
- Chao S.
- Charlton P.
- Chassande-Mottin E.
- Chatterjee D.
- Cheeseboro B.âD.
- Chen H.âY.
- Chen Y.
- Cheng H.-P.
- Chincarini A.
- Chiummo A.
- Chmiel T.
- Cho H.âS.
- Cho M.
- Chow J.âH.
- Christensen N.
- Chu Q.
- Chua A.âJ.âK.
- Chua S.
- Chung A.âK.âW.
- Chung S.
- Ciani G.
- Ciolfi R.
- Cirelli C.âE.
- Cirone A.
- Clara F.
- Clark J.âA.
- Cleva F.
- Cocchieri C.
- Coccia E.
- Cohadon P.-F.
- Colla A.
- Collette C.âG.
- Cominsky L.âR.
- Constancio M.
- Conti L.
- Cooper S.âJ.
- Corban P.
- Corbitt T.âR.
- Corley K.âR.
- Cornish N.
- Corsi A.
- Cortese S.
- Costa C.âA.
- Coughlin M.âW.
- Coughlin S.âB.
- Coulon J.-P.
- Countryman S.âT.
- Couvares P.
- Covas P.âB.
- Cowan E.âE.
- Coward D.âM.
- Cowart M.âJ.
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- Zhu X.âJ.
- Zucker Michael E
- Zweizig J.
- Publication venue
- 'American Physical Society (APS)'
- Publication date
- 01/01/2017
- Field of study
During their first observational run, the two Advanced LIGO detectors attained an unprecedented sensitivity, resulting in the first direct detections of gravitational-wave signals produced by stellar-mass binary black hole systems. This paper reports on an all-sky search for gravitational waves (GWs) from merging intermediate mass black hole binaries (IMBHBs). The combined results from two independent search techniques were used in this study: the first employs a matched-filter algorithm that uses a bank of filters covering the GW signal parameter space, while the second is a generic search for GW transients (bursts). No GWs from IMBHBs were detected; therefore, we constrain the rate of several classes of IMBHB mergers. The most stringent limit is obtained for black holes of individual mass
100 M â, with spins aligned with the binary orbital angular momentum. For such systems, the merger rate is constrained to be less than
0.93 Gpcâ3yrâ1 in comoving units at the 90% confidence level, an improvement of nearly 2 orders of magnitude over previous upper limits
First low-frequency Einstein@Home all-sky search for continuous gravitational waves in Advanced LIGO data
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- Zucker Michael E
- Zweizig J.
- Publication venue
- 'American Physical Society (APS)'
- Publication date
- 01/01/2017
- Field of study
We report results of a deep all-sky search for periodic gravitational waves from isolated neutron stars in data from the first Advanced LIGO observing run. This search investigates the low frequency range of Advanced LIGO data, between 20 and 100 Hz, much of which was not explored in initial LIGO. The search was made possible by the computing power provided by the volunteers of the Einstein@Home project. We find no significant signal candidate and set the most stringent upper limits to date on the amplitude of gravitational wave signals from the target population, corresponding to a sensitivity depth of 48.7 [1/root Hz]. At the frequency of best strain sensitivity, near 100 Hz, we set 90% confidence upper limits of 1.8 x 10(-25). At the low end of our frequency range, 20 Hz, we achieve upper limits of 3.9 x 10(-24). At 55 Hz we can exclude sources with ellipticities greater than 10(-5) within 100 pc of Earth with fiducial value of the principal moment of inertia of 10(38) kg m(2)
Multi-messenger Observations of a Binary Neutron Star Merger
- Author
- (Deeper DWF
- Aartsen M. G.
- Abbott B. P.
- Abbott R.
- Abbott T. D.
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- Publication venue
- 'American Astronomical Society'
- Publication date
- 28/10/2022
- Field of study
On 2017 August 17 a binary neutron star coalescence candidate (later
designated GW170817) with merger time 12:41:04 UTC was observed through
gravitational waves by the Advanced LIGO and Advanced Virgo detectors.
The Fermi Gamma-ray Burst Monitor independently detected a gamma-ray
burst (GRB 170817A) with a time delay of ⌠1.7 {{s}} with respect to
the merger time. From the gravitational-wave signal, the source was
initially localized to a sky region of 31 deg2 at a
luminosity distance of {40}-8+8 Mpc and with
component masses consistent with neutron stars. The component masses
were later measured to be in the range 0.86 to 2.26 {M}ÈŻ
. An extensive observing campaign was launched across the
electromagnetic spectrum leading to the discovery of a bright optical
transient (SSS17a, now with the IAU identification of AT 2017gfo) in NGC
4993 (at ⌠40 {{Mpc}}) less than 11 hours after the merger by the
One-Meter, Two Hemisphere (1M2H) team using the 1 m Swope Telescope. The
optical transient was independently detected by multiple teams within an
hour. Subsequent observations targeted the object and its environment.
Early ultraviolet observations revealed a blue transient that faded
within 48 hours. Optical and infrared observations showed a redward
evolution over âŒ10 days. Following early non-detections, X-ray and
radio emission were discovered at the transientâs position ⌠9
and ⌠16 days, respectively, after the merger. Both the X-ray and
radio emission likely arise from a physical process that is distinct
from the one that generates the UV/optical/near-infrared emission. No
ultra-high-energy gamma-rays and no neutrino candidates consistent with
the source were found in follow-up searches. These observations support
the hypothesis that GW170817 was produced by the merger of two neutron
stars in NGC 4993 followed by a short gamma-ray burst (GRB 170817A) and
a kilonova/macronova powered by the radioactive decay of r-process
nuclei synthesized in the ejecta.</p
Ocular indicators of Alzheimerâs: exploring disease in the retina
- Author
- A Almazroa
- A Aloisi
- A Finelli
- A Kesler
- A London
- A Ning
- A Surguchov
- A Trost
- AA Sadun
- AA Sadun
- AB Einarsdottir
- AI Pogue
- AO Ardiles
- AU Bayer
- B Katz
- B Katz
- B Liu
- BB Holmes
- BM Davis
- BW Jones
- C Kerbage
- C Kerbage
- C La Morgia
- C La Morgia
- C Paquet
- C Schon
- CA Curcio
- CA Mathis
- CA Ross
- CN Lee
- CR Jack Jr
- CS Tsai
- CY Cheung
- CY Ho
- D Bach-Holm
- D Goldeck
- D Liu
- DB Fraller
- DJ Selkoe
- DJ Selkoe
- DL Price
- DP Devanand
- DR Hinton
- E Granholm
- E Marziani
- E Salobrar-Garcia
- EO Oktem
- F Berisha
- FJ Ascaso
- FK Wiseman
- FZ Javaid
- G Coppola
- G Feke
- GC Gilmore
- GC Gilmore
- GL Trick
- GL Trick
- H Kergoat
- H Tamura
- H Zhao
- HA Bayhan
- HV Danesh-Meyer
- I Bodis-Wollner
- I Greeve
- I Maharshak
- J Avila
- J Bruban
- J Hardy
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- JD Ding
- JM Larrosa
- JM Nolan
- JM Sivak
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- K Carmine-Simmen
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- K Ohno-Matsui
- K Tsuruma
- Keith L. Black
- KG Mawuenyega
- KU Loffler
- L Bei
- L Cao
- L Gao
- L Gao
- L Guo
- L Guo
- L Steardo Jr
- LV Kessing
- LY Chang
- LY Du
- M Baumgart
- M Gharbiya
- M Goedert
- M Goedert
- M Hasegawa
- M Jucker
- M Koronyo-Hamaoui
- M Ono
- M Parnell
- M Rizzo
- M Schwartz
- MA Meraz-Rios
- MA Williams
- Maya Koronyo-Hamaoui
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- MF Cordeiro
- MF Mendez
- MJ Perez de Lara
- MM Edwards
- MM Moschos
- MP Bambo
- MP Bambo
- MS Byerly
- Nadav J. Hart
- NC Inestrosa
- NE Carlson
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- OG James
- P Jindahra
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- SE Perez
- SH Lee
- SJ McKinnon
- SL Risacher
- SS More
- SW Park
- T Cutler
- T Dentchev
- T Moreno-Ramos
- T Wyss-Coray
- TJ Crawford
- TR Hedges 3rd
- U Kayabasi
- V Calsolaro
- V Hook
- V Kavcic
- V Luibl
- V Parisi
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- VK Gupta
- WA Fletcher
- Y He
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- Y Lu
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- Y Yang
- Yosef Koronyo
- YT Ong
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- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
- âŠ