790 research outputs found
Simultaneous Diagonal and Off Diagonal Order in the Bose--Hubbard Hamiltonian
The Bose-Hubbard model exhibits a rich phase diagram consisting both of
insulating regimes where diagonal long range (solid) order dominates as well as
conducting regimes where off diagonal long range order (superfluidity) is
present. In this paper we describe the results of Quantum Monte Carlo
calculations of the phase diagram, both for the hard and soft core cases, with
a particular focus on the possibility of simultaneous superfluid and solid
order. We also discuss the appearance of phase separation in the model. The
simulations are compared with analytic calculations of the phase diagram and
spin wave dispersion.Comment: 28 pages plus 24 figures, uuencoded Revtex+postscript file
Lessons from Agriculture for the Sustainable Management of Malaria Vectors
The effectiveness of insecticide-treated bed nets and indoor insecticide sprays to control adult mosquito vectors is being threatened by the spread of insecticide resistance. We argue for expanding beyond “insecticide monotherapy” to more sustainable integrated vector management strategies that use optimal suites of control tactics. Experience in agriculture suggests that such integrated approaches can provide more effective and durable pest management. This shift will require increased investment in research and translational science. Failure to act risks a resurgence of malaria and erosion of community support and donor commitment
Mott Transition in An Anyon Gas
We introduce and analyze a lattice model of anyons in a periodic potential
and an external magnetic field which exhibits a transition from a Mott
insulator to a quantum Hall fluid. The transition is characterized by the anyon
statistics, , which can vary between Fermions, , and Bosons,
. For bosons the transition is in the universality class of the
classical three-dimensional XY model. Near the Fermion limit, the transition is
described by a massless Dirac theory coupled to a Chern-Simons gauge
field. Analytic calculations perturbative in , and also a large
N-expansion, show that due to gauge fluctuations, the critical properties of
the transition are dependent on the anyon statistics. Comparison with previous
calcualations at and near the Boson limit, strongly suggest that our lattice
model exhibits a fixed line of critical points, with universal critical
properties which vary continuosly and monotonically as one passes from Fermions
to Bosons. Possible relevance to experiments on the transitions between
plateaus in the fractional quantum Hall effect and the magnetic field-tuned
superconductor-insulator transition are briefly discussed.Comment: text and figures in Latex, 41 pages, UBCTP-92-28, CTP\#215
Theory of Two-Dimensional Quantum Heisenberg Antiferromagnets with a Nearly Critical Ground State
We present the general theory of clean, two-dimensional, quantum Heisenberg
antiferromagnets which are close to the zero-temperature quantum transition
between ground states with and without long-range N\'{e}el order. For
N\'{e}el-ordered states, `nearly-critical' means that the ground state
spin-stiffness, , satisfies , where is the
nearest-neighbor exchange constant, while `nearly-critical' quantum-disordered
ground states have a energy-gap, , towards excitations with spin-1,
which satisfies . Under these circumstances, we show that the
wavevector/frequency-dependent uniform and staggered spin susceptibilities, and
the specific heat, are completely universal functions of just three
thermodynamic parameters. Explicit results for the universal scaling functions
are obtained by a expansion on the quantum non-linear sigma model,
and by Monte Carlo simulations. These calculations lead to a variety of
testable predictions for neutron scattering, NMR, and magnetization
measurements. Our results are in good agreement with a number of numerical
simulations and experiments on undoped and lightly-doped .Comment: 81 pages, REVTEX 3.0, smaller updated version, YCTP-xxx
Condensed matter and AdS/CFT
I review two classes of strong coupling problems in condensed matter physics,
and describe insights gained by application of the AdS/CFT correspondence. The
first class concerns non-zero temperature dynamics and transport in the
vicinity of quantum critical points described by relativistic field theories. I
describe how relativistic structures arise in models of physical interest,
present results for their quantum critical crossover functions and
magneto-thermoelectric hydrodynamics. The second class concerns symmetry
breaking transitions of two-dimensional systems in the presence of gapless
electronic excitations at isolated points or along lines (i.e. Fermi surfaces)
in the Brillouin zone. I describe the scaling structure of a recent theory of
the Ising-nematic transition in metals, and discuss its possible connection to
theories of Fermi surfaces obtained from simple AdS duals.Comment: 39 pages, 12 figures; Lectures at the 5th Aegean summer school, "From
gravity to thermal gauge theories: the AdS/CFT correspondence", and the De
Sitter Lecture Series in Theoretical Physics 2009, University of Groninge
Effect of Tumor-Treating Fields Plus Maintenance Temozolomide vs Maintenance Temozolomide Alone on Survival in Patients With Glioblastoma: A Randomized Clinical Trial.
Tumor-treating fields (TTFields) is an antimitotic treatment modality that interferes with glioblastoma cell division and organelle assembly by delivering low-intensity alternating electric fields to the tumor.
To investigate whether TTFields improves progression-free and overall survival of patients with glioblastoma, a fatal disease that commonly recurs at the initial tumor site or in the central nervous system.
In this randomized, open-label trial, 695 patients with glioblastoma whose tumor was resected or biopsied and had completed concomitant radiochemotherapy (median time from diagnosis to randomization, 3.8 months) were enrolled at 83 centers (July 2009-2014) and followed up through December 2016. A preliminary report from this trial was published in 2015; this report describes the final analysis.
Patients were randomized 2:1 to TTFields plus maintenance temozolomide chemotherapy (n = 466) or temozolomide alone (n = 229). The TTFields, consisting of low-intensity, 200 kHz frequency, alternating electric fields, was delivered (≥ 18 hours/d) via 4 transducer arrays on the shaved scalp and connected to a portable device. Temozolomide was administered to both groups (150-200 mg/m2) for 5 days per 28-day cycle (6-12 cycles).
Progression-free survival (tested at α = .046). The secondary end point was overall survival (tested hierarchically at α = .048). Analyses were performed for the intent-to-treat population. Adverse events were compared by group.
Of the 695 randomized patients (median age, 56 years; IQR, 48-63; 473 men [68%]), 637 (92%) completed the trial. Median progression-free survival from randomization was 6.7 months in the TTFields-temozolomide group and 4.0 months in the temozolomide-alone group (HR, 0.63; 95% CI, 0.52-0.76; P < .001). Median overall survival was 20.9 months in the TTFields-temozolomide group vs 16.0 months in the temozolomide-alone group (HR, 0.63; 95% CI, 0.53-0.76; P < .001). Systemic adverse event frequency was 48% in the TTFields-temozolomide group and 44% in the temozolomide-alone group. Mild to moderate skin toxicity underneath the transducer arrays occurred in 52% of patients who received TTFields-temozolomide vs no patients who received temozolomide alone.
In the final analysis of this randomized clinical trial of patients with glioblastoma who had received standard radiochemotherapy, the addition of TTFields to maintenance temozolomide chemotherapy vs maintenance temozolomide alone, resulted in statistically significant improvement in progression-free survival and overall survival. These results are consistent with the previous interim analysis.
clinicaltrials.gov Identifier: NCT00916409
Virulence evolution in response to vaccination: the case of malaria
Invited paper for the journal Vaccine summarising a workshop at Rutgers University in July 2005 on Vaccination and its evolutionary consequencesOne theory of why some pathogens are virulent (i.e. they damage their host) is that they need to extract resources from their host in order to compete for transmission to new hosts, and resource extraction can damage the host. Here we describe our studies in malaria that test this idea. We go on to show that host immunity can exacerbate selection for virulence and therefore that vaccines that reduce pathogen replication may select for more virulent pathogens, eroding the benefits of vaccination and putting the unvaccinated at greater risk. We suggest that in disease contexts where wild-type parasites can be transmitted through vaccinated hosts, evolutionary outcomes need to be considered
Search for a W' boson decaying to a bottom quark and a top quark in pp collisions at sqrt(s) = 7 TeV
Results are presented from a search for a W' boson using a dataset
corresponding to 5.0 inverse femtobarns of integrated luminosity collected
during 2011 by the CMS experiment at the LHC in pp collisions at sqrt(s)=7 TeV.
The W' boson is modeled as a heavy W boson, but different scenarios for the
couplings to fermions are considered, involving both left-handed and
right-handed chiral projections of the fermions, as well as an arbitrary
mixture of the two. The search is performed in the decay channel W' to t b,
leading to a final state signature with a single lepton (e, mu), missing
transverse energy, and jets, at least one of which is tagged as a b-jet. A W'
boson that couples to fermions with the same coupling constant as the W, but to
the right-handed rather than left-handed chiral projections, is excluded for
masses below 1.85 TeV at the 95% confidence level. For the first time using LHC
data, constraints on the W' gauge coupling for a set of left- and right-handed
coupling combinations have been placed. These results represent a significant
improvement over previously published limits.Comment: Submitted to Physics Letters B. Replaced with version publishe
Search for direct production of charginos and neutralinos in events with three leptons and missing transverse momentum in √s = 7 TeV pp collisions with the ATLAS detector
A search for the direct production of charginos and neutralinos in final states with three electrons or muons and missing transverse momentum is presented. The analysis is based on 4.7 fb−1 of proton–proton collision data delivered by the Large Hadron Collider and recorded with the ATLAS detector. Observations are consistent with Standard Model expectations in three signal regions that are either depleted or enriched in Z-boson decays. Upper limits at 95% confidence level are set in R-parity conserving phenomenological minimal supersymmetric models and in simplified models, significantly extending previous results
Search for the standard model Higgs boson decaying into two photons in pp collisions at sqrt(s)=7 TeV
A search for a Higgs boson decaying into two photons is described. The
analysis is performed using a dataset recorded by the CMS experiment at the LHC
from pp collisions at a centre-of-mass energy of 7 TeV, which corresponds to an
integrated luminosity of 4.8 inverse femtobarns. Limits are set on the cross
section of the standard model Higgs boson decaying to two photons. The expected
exclusion limit at 95% confidence level is between 1.4 and 2.4 times the
standard model cross section in the mass range between 110 and 150 GeV. The
analysis of the data excludes, at 95% confidence level, the standard model
Higgs boson decaying into two photons in the mass range 128 to 132 GeV. The
largest excess of events above the expected standard model background is
observed for a Higgs boson mass hypothesis of 124 GeV with a local significance
of 3.1 sigma. The global significance of observing an excess with a local
significance greater than 3.1 sigma anywhere in the search range 110-150 GeV is
estimated to be 1.8 sigma. More data are required to ascertain the origin of
this excess.Comment: Submitted to Physics Letters
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