Implementación de controles internos en la empresa SABIJOUX S.A. en la ciudad de Guayaquil para el año 2012.

La empresa Sabijoux S.A es una mediana empresa dedicada a vender productos de Bisutería y artículos varios con la finalidad de satisfacer las necesidades del cliente en cuanto a su manera de proyectar imagen. Esta empresa ha venido creciendo y exporta sus productos, de tal forma que ha venido creciendo, por lo que necesita de  muchos más controles y supervisiones, Existe mucho desfase en cuanto controles, no tienen políticas, procedimientos para cada departamento ni reglamentos internos, por esto hemos realizado este proyecto con la finalidad de dar alineamientos, que mejores el funcionamiento de la empresa, cumpliendo con objetivos y metas. Para esto hemos determinado las falencias y errores que tiene la compañía para poder tomar las correcciones en todos los departamentos, y damos a conocer las directrices que debemos de Implementar para unos mejor resultados quo lo mostraran en los estados Financieros. ·   Bisutería ·   Directrices ·   Pymes ·   Errores ·   Estados Financiero

Deep Markov Random Field for Image Modeling

Markov Random Fields (MRFs), a formulation widely used in generative image modeling, have long been plagued by the lack of expressive power. This issue is primarily due to the fact that conventional MRFs formulations tend to use simplistic factors to capture local patterns. In this paper, we move beyond such limitations, and propose a novel MRF model that uses fully-connected neurons to express the complex interactions among pixels. Through theoretical analysis, we reveal an inherent connection between this model and recurrent neural networks, and thereon derive an approximated feed-forward network that couples multiple RNNs along opposite directions. This formulation combines the expressive power of deep neural networks and the cyclic dependency structure of MRF in a unified model, bringing the modeling capability to a new level. The feed-forward approximation also allows it to be efficiently learned from data. Experimental results on a variety of low-level vision tasks show notable improvement over state-of-the-arts.Comment: Accepted at ECCV 201

Mejoraramiento de la eficiencia de la proteina de los pastos en bovinos de leche utilizando cuatro formulaciones de balanceados

La ganadería es la actividad agropecuaria más difundida en el mundo, siendo la principal fuente de alimento el pasto. En esta investigación se evaluó la eficiencia del uso de la proteína bruta (PB) en pastos, utilizando cuatro formulaciones diferentes de balanceados en la alimentación de bovinos. Cuando los pastos tuvieron >18% de PB, los mejores resultados se obtuvieron con un balanceado 12% de (PB), y los elementos no nitrogenados (ENN) en un 68% aumentó la producción de leche, disminuyendo el contenido de proteína (pal 16% y un (ENN) <57%, aumentando la producción de leche y el contenido de proteína (p<0,05), mejorando el contenido de MUN en leche

SOYFIT-Yogurt de soya

Ante la necesidad que nuestro equipo de trabajo capto sobre los consumidores de yogurt. Presentamos una alternativa diferente en la cual podamos tener un producto innovador en el mercado. La idea de negocio se planteó estableciendo un nicho de mercado en la cual nos dirigiremos a personas que consumen productos saludables. Esta idea de negocio va permitir captar a un público distinto al de otras grandes marcas. SoyFit está compuesto con productos naturales y con proveedores locales. Asimismo, cada ingrediente está seleccionado de forma que ofrece al público un producto de calidad. Además, el producto es realizado de manera artesanal y distribuido a bioferias, consumidores locales y gimnasios. En las próximas páginas del presente trabajo se detallara como fue el proceso de realización de nuestra idea de negocio. En cada página se presentara las validaciones, modelo negocio, pronósticos, fuentes, etc. Con el objetivo de que nuestro producto sea rentable a largo plazo. En síntesis, al finalizar las validaciones pudimos determinar que nuestro producto es viable y nos generara en los siguientes años un retorno económico junto con utilidades. Con ello se busca seguir creciendo nuestra idea de negocio y quizás en un futuro ofrecerlo en un mercado extranjero.Given the need for our team to capture yogurt consumers. We present a different alternative in which we can have an innovative product in the market. The business idea was raised by establishing a market niche in which we will address people who consume healthy products. This business idea will allow to attract a different audience from other major brands. SoyFit is made up of natural products and local suppliers. Likewise, each ingredient is selected in a way that offers the public a quality product. In addition, the product is made by hand and distributed to bioferias, local consumers and gyms. In the next pages of this work we will detail how the process of realization of our business idea was. Validations, business model, forecasts, sources, etc. will be presented on each page. With the aim of making our product profitable in the long term. In summary, at the end of the validations we could determine that our product it is viable and will generate in the following years an economic return along with utilities. This seeks to continue growing our business idea and perhaps in the future offer it in a foreign market.Trabajo de investigació

Monitoring and prevalence rates of metabolic syndrome in military veterans with serious mental illness

Background: Cardiovascular disease is the leading cause of mortality among patients with serious mental illness (SMI) and the prevalence of metabolic syndrome-a constellation of cardiovascular risk factors-is significantly higher in these patients than in the general population. Metabolic monitoring among patients using second generation antipsychotics (SGAs)-a risk factor for metabolic syndrome-has been shown to be inadequate despite the release of several guidelines. However, patients with SMI have several factors independent of medication use that predispose them to a higher prevalence of metabolic syndrome. Our study therefore examines monitoring and prevalence of metabolic syndrome in patients with SMI, including those not using SGAs. Methods and Findings: We retrospectively identified all patients treated at a Veterans Affairs Medical Center with diagnoses of schizophrenia, schizoaffective disorder or bipolar disorder during 2005-2006 and obtained demographic and clinical data. Incomplete monitoring of metabolic syndrome was defined as being unable to determine the status of at least one of the syndrome components. Of the 1,401 patients included (bipolar disorder: 822; schizophrenia: 222; and schizoaffective disorder: 357), 21.4% were incompletely monitored. Only 54.8% of patients who were not prescribed SGAs and did not have previous diagnoses of hypertension or hypercholesterolemia were monitored for all metabolic syndrome components compared to 92.4% of patients who had all three of these characteristics. Among patients monitored for metabolic syndrome completely, age-adjusted prevalence of the syndrome was 48.4%, with no significant difference between the three psychiatric groups. Conclusions: Only one half of patients with SMI not using SGAs or previously diagnosed with hypertension and hypercholesterolemia were completely monitored for metabolic syndrome components compared to greater than 90% of those with these characteristics. With the high prevalence of metabolic syndrome seen in this population, there appears to be a need to intensify efforts to reduce this monitoring gap

Genome-wide association and Mendelian randomisation analysis provide insights into the pathogenesis of heart failure

Heart failure (HF) is a leading cause of morbidity and mortality worldwide. A small proportion of HF cases are attributable to monogenic cardiomyopathies and existing genome-wide association studies (GWAS) have yielded only limited insights, leaving the observed heritability of HF largely unexplained. We report results from a GWAS meta-analysis of HF comprising 47,309 cases and 930,014 controls. Twelve independent variants at 11 genomic loci are associated with HF, all of which demonstrate one or more associations with coronary artery disease (CAD), atrial fibrillation, or reduced left ventricular function, suggesting shared genetic aetiology. Functional analysis of non-CAD-associated loci implicate genes involved in cardiac development (MYOZ1, SYNPO2L), protein homoeostasis (BAG3), and cellular senescence (CDKN1A). Mendelian randomisation analysis supports causal roles for several HF risk factors, and demonstrates CAD-independent effects for atrial fibrillation, body mass index, and hypertension. These findings extend our knowledge of the pathways underlying HF and may inform new therapeutic strategies

Large expert-curated database for benchmarking document similarity detection in biomedical literature search

Document recommendation systems for locating relevant literature have mostly relied on methods developed a decade ago. This is largely due to the lack of a large offline gold-standard benchmark of relevant documents that cover a variety of research fields such that newly developed literature search techniques can be compared, improved and translated into practice. To overcome this bottleneck, we have established the RElevant LIterature SearcH consortium consisting of more than 1500 scientists from 84 countries, who have collectively annotated the relevance of over 180 000 PubMed-listed articles with regard to their respective seed (input) article/s. The majority of annotations were contributed by highly experienced, original authors of the seed articles. The collected data cover 76% of all unique PubMed Medical Subject Headings descriptors. No systematic biases were observed across different experience levels, research fields or time spent on annotations. More importantly, annotations of the same document pairs contributed by different scientists were highly concordant. We further show that the three representative baseline methods used to generate recommended articles for evaluation (Okapi Best Matching 25, Term Frequency-Inverse Document Frequency and PubMed Related Articles) had similar overall performances. Additionally, we found that these methods each tend to produce distinct collections of recommended articles, suggesting that a hybrid method may be required to completely capture all relevant articles. The established database server located at https://relishdb.ict.griffith.edu.au is freely available for the downloading of annotation data and the blind testing of new methods. We expect that this benchmark will be useful for stimulating the development of new powerful techniques for title and title/abstract-based search engines for relevant articles in biomedical research.Peer reviewe

The continuity of effect of schizophrenia polygenic risk score and patterns of cannabis use on transdiagnostic symptom dimensions at first-episode psychosis: findings from the EU-GEI study

Abstract: Diagnostic categories do not completely reflect the heterogeneous expression of psychosis. Using data from the EU-GEI study, we evaluated the impact of schizophrenia polygenic risk score (SZ-PRS) and patterns of cannabis use on the transdiagnostic expression of psychosis. We analysed first-episode psychosis patients (FEP) and controls, generating transdiagnostic dimensions of psychotic symptoms and experiences using item response bi-factor modelling. Linear regression was used to test the associations between these dimensions and SZ-PRS, as well as the combined effect of SZ-PRS and cannabis use on the dimensions of positive psychotic symptoms and experiences. We found associations between SZ-PRS and (1) both negative (B = 0.18; 95%CI 0.03–0.33) and positive (B = 0.19; 95%CI 0.03–0.35) symptom dimensions in 617 FEP patients, regardless of their categorical diagnosis; and (2) all the psychotic experience dimensions in 979 controls. We did not observe associations between SZ-PRS and the general and affective dimensions in FEP. Daily and current cannabis use were associated with the positive dimensions in FEP (B = 0.31; 95%CI 0.11–0.52) and in controls (B = 0.26; 95%CI 0.06–0.46), over and above SZ-PRS. We provide evidence that genetic liability to schizophrenia and cannabis use map onto transdiagnostic symptom dimensions, supporting the validity and utility of the dimensional representation of psychosis. In our sample, genetic liability to schizophrenia correlated with more severe psychosis presentation, and cannabis use conferred risk to positive symptomatology beyond the genetic risk. Our findings support the hypothesis that psychotic experiences in the general population have similar genetic substrates as clinical disorders

Gestión del conocimiento. Perspectiva multidisciplinaria. Volumen 17

El libro “Gestión del Conocimiento. Perspectiva Multidisciplinaria”, Volumen 17 de la Colección Unión Global, es resultado de investigaciones. Los capítulos del libro, son resultados de investigaciones desarrolladas por sus autores. El libro es una publicación internacional, seriada, continua, arbitrada, de acceso abierto a todas las áreas del conocimiento, orientada a contribuir con procesos de gestión del conocimiento científico, tecnológico y humanístico. Con esta colección, se aspira contribuir con el cultivo, la comprensión, la recopilación y la apropiación social del conocimiento en cuanto a patrimonio intangible de la humanidad, con el propósito de hacer aportes con la transformación de las relaciones socioculturales que sustentan la construcción social de los saberes y su reconocimiento como bien público