710 research outputs found
Intergenerational change and familial aggregation of body mass index
- Author
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2011
- Field of study
The relationship between parental BMI and that of their adult offspring, when increased adiposity can become a clinical issue, is unknown. We investigated the intergenerational change in body mass index (BMI) distribution, and examined the sex-specific relationship
between parental and adult offspring BMI. Intergenerational
change in the distribution of adjusted BMI in 1,443
complete families (both parents and at least one offspring)
with 2,286 offspring (1,263 daughters and 1,023 sons) from
the west of Scotland, UK, was investigated using quantile
regression. Familial correlations were estimated from
linear mixed effects regression models. The distribution
of BMI showed little intergenerational change in the normal
range (\25 kg/m2), decreasing overweightness (25â
\30 kg/m2) and increasing obesity (C30 kg/m2). Median
BMI was static across generations in males and decreased
in females by 0.4 (95% CI: 0.0, 0.7) kg/m2; the 95th percentileincreased by 2.2 (1.1, 3.2) kg/m2 in males and 2.7
(1.4, 3.9) kg/m2 in females. Mothersâ BMI was more
strongly associated with daughtersâ BMI than was fathersâ
(correlation coefficient (95% CI): mothers 0.31 (0.27,
0.36), fathers 0.19 (0.14, 0.25); P = 0.001). Mothersâ and
fathersâ BMI were equally correlated with sonsâ BMI
(correlation coefficient: mothers 0.28 (0.22, 0.33), fathers
0.27 (0.22, 0.33). The increase in BMI between generations
was concentrated at the upper end of the distribution. This,
alongside the strong parent-offspring correlation, suggests that the increase in BMI is disproportionally greater among
offspring of heavier parents. Familial influences on BMI among middle-aged women appear significantly stronger from mothers than father
Child Fitness and Fatherâs BMI Are Important Factors in Childhood Obesity: A School Based Cross-Sectional Study
- Author
- A Rees
- A Sarkadi
- Anwen Rees
- B Hitze
- BP Hands
- BS Metcalf
- C Riddoch
- CM Wright
- D Hosmer
- DL Johannsen
- DS Freedman
- E Flouri
- E Freeman
- E Goodman
- EM Perez-Pastor
- EM van Sluijs
- G Sandercock
- Gareth Knox
- GS Berenson
- HD McCarthy
- I Suttleworth
- J Kain
- JE Shaw
- JM Major
- Julien Baker
- K Finn
- L Newland
- LJ Griffiths
- M Saker
- M Wake
- NE Thomas
- NE Thomas
- Non E. Thomas
- P Zimmet
- R Figueroa-Colon
- R Goldman
- RM Lauer
- RM Lauer
- S Howarth
- Sinead Brophy
- SL Arluk
- Stephen L. Atkin
- TF Eagle
- TJ Cole
- V Burke
- WT Boyce
- Publication venue
- Public Library of Science
- Publication date
- 01/01/2012
- Field of study
BACKGROUND: This study examines obesity and factors associated with obesity in children aged 11-13 years in the UK. METHODS: 1147 children from ten secondary schools participated in a health survey that included blood samples, fitness test and anthropometric measures. Factors associated with obesity were examined using multilevel logistic regression. FINDINGS: Of the children examined (490 male; 657 female) a third were overweight, 1 in 6 had elevated blood pressure, more than 1 in 10 had high cholesterol, 58% consumed more fat than recommended, whilst 37% were classified as unfit. Children in deprived areas had a higher proportion of risk factors; for example, they had higher blood pressure (20% (deprived) compared to 11% (non-deprived), difference: 9.0% (95%CI: 4.7%-13.4%)). Obesity is associated with risk factors for heart disease and diabetes. Maintaining fitness is associated with a reduction in the risk factors for heart disease (high blood pressure and cholesterol) but not on risk factors for diabetes (insulin levels). In order of importance, the main risk factors for childhood obesity are being unfit, having an obese father, and being large at birth. CONCLUSION: The high proportion of children with risk factors suggests future interventions need to focus on community and policy change to shift the population norm rather than targeting the behaviour of high risk individuals. Interventions need to focus on mothers' lifestyle in pregnancy, fathers' health, as well as promoting fitness among children. Obesity was not associated with deprivation. Therefore, strategies should be adopted in both deprived and non deprived areas
Body mass index and height over three generations: evidence from the Lifeways cross-generational cohort study
- Author
- A Hill
- B Cogill
- C Kleiser
- CC Kelleher
- CC Kelleher
- Cecily C Kelleher
- Celine M Murrin
- CM Murrin
- D O'Mahony
- E Hypponen
- EM Perez-Pastor
- G Davey Smith
- G Kaati
- Gabrielle E Kelly
- HH Maes
- HJ Kaplowitz
- HT Sorensen
- I Emanuel
- I Niedhammer
- JK Lake
- K Silventoinen
- KJ Greenlund
- KL Whitaker
- L Dubois
- L Li
- L Li
- LH Lumey
- M Guillaume
- M Sekine
- MK Simonsen
- MM Davis
- N Wray
- RC Whitaker
- Richard E Tremblay
- RM Merrill
- S Danielzik
- T Cole
- TJ Cole
- WH Dietz
- WHO
- Publication venue
- BioMed Central
- Publication date
- 01/01/2012
- Field of study
Background: Obesity and its measure of body mass index are strongly determined by parental body size. Debate continues as to whether both parents contribute equally to offspring body mass which is key to understanding the aetiology of the disease. The aim of this study was to use cohort data from three generations of one family to
examine the relative maternal and paternal associations with offspring body mass index and how these associations compare with family height to demonstrate evidence of genetic or environmental cross-generational transmission.
Methods: 669 of 1082 families were followed up in 2007/8 as part of the Lifeways study, a prospective observational cross-generation linkage cohort. Height and weight were measured in 529 Irish children aged 5 to 7 years and were self-reported by parents and grandparents. All adults provided information on self-rated health, education status, and indicators of income, diet and physical activity. Associations between the weight, height, and body mass index of family members were examined with mixed models and heritability estimates computed using linear regression analysis.
Results: Self-rated health was associated with lower BMI for all family members, as was age for children. When these effects were accounted for evidence of familial associations of BMI from one generation to the next was more apparent in the maternal line. Heritability estimates were higher (h2 = 0.40) for mother-offspring pairs compared to father-offspring pairs (h2 = 0.22). In the previous generation, estimates were higher between mothersparents (h2 = 0.54-0.60) but not between fathers-parents (h2 = -0.04-0.17). Correlations between mother and offspring across two generations remained significant when modelled with fixed variables of socioeconomic status, health, and lifestyle. A similar analysis of height showed strong familial associations from maternal and paternal lines across each generation.
Conclusions: This is the first family cohort study to report an enduring association between mother and offspring BMI over three generations. The evidence of BMI transmission over three generations through the maternal line in an observational study corroborates the findings of animal studies. A more detailed analysis of geno and
phenotypic data over three generations is warranted to understand the nature of this maternal-offspring relationship.TS 24.4.1
Associations between severity of obesity in childhood and adolescence, obesity onset and parental BMI: a longitudinal cohort study
- Author
- AA Mamun
- AJ Stunkard
- AM Magarey
- AM Toschke
- C Maffeis
- C Maffeis
- C Marcus
- CM Haworth
- DL Safer
- DS Freedman
- DS Freedman
- EM Perez-Pastor
- G Valerio
- H B Schiöth
- I Bralic
- IS Farooqi
- J A Jacobsson
- J Wardle
- JG Kral
- JJ Reilly
- JK Lake
- K Silventoinen
- KH Pietilainen
- KK Ong
- L Dubois
- LY Gibson
- M Neovius
- MF Rolland-Cachera
- P Danielsson
- R Fredriksson
- R Unger
- RC Whitaker
- RI Berkowitz
- S Danielzik
- S Danielzik
- SM Garn
- T Quattrin
- T Sobko
- TJ Cole
- V Burke
- V Shrewsbury
- V Svensson
- WH Dietz
- Publication venue
- Nature Publishing Group
- Publication date
- 01/01/2011
- Field of study
Objective: To explore the relationship between severity of obesity at age 7 and age 15, age at onset of obesity, and parental body mass index (BMI) in obese children and adolescents. Design: Longitudinal cohort study.Subjects:Obese children (n231) and their parents (n462) from the Swedish National Childhood Obesity Centre. Methods: Multivariate regression analyses were applied with severity of obesity (BMI standard deviation score (BMI SDS)) and onset of obesity as dependent variables. The effect of parental BMI was evaluated and in the final models adjusted for gender, parental education, age at onset of obesity, severity of obesity at age 7 and obesity treatment. Results: For severity of obesity at age 7, a positive correlation with maternal BMI was indicated (P<0.05). Severity of obesity at this age also showed a strong negative correlation with the age at onset of obesity. Severity of obesity at age 15 was significantly correlated with both maternal and paternal BMI (Pâ„0.01). In addition, BMI SDS at age 15 differed by gender (higher for boys) and was positively correlated with severity of obesity at age 7 and negatively correlated with treatment. Also, a negative correlation was indicated at this age for parental education. No correlation with age at onset was found at age 15. For age at onset of obesity there was no relevant correlation with parental BMI. Children within the highest tertile of the BMI SDS range were more likely to have two obese parents. Conclusion: The impact of parental BMI on the severity of obesity in children is strengthened as the child grows into adolescence, whereas the age at onset is probably of less importance than previously thought. The influence of parental relative weight primarily affects the severity of childhood obesity and not the timing. © 2011 Macmillan Publishers Limited All rights reserved.link_to_subscribed_fulltex
Search for new phenomena in final states with an energetic jet and large missing transverse momentum in pp collisions at â s = 8 TeV with the ATLAS detector
- Author
- Aad G
- Abbott B
- Abbott DC
- Abeling K
- Abhayasinghe DK
- Abidi SH
- AbouZeid OS
- Abraham NL
- Abramowicz H
- Abreu H
- Abud AA
- Abulaiti Y
- Acharya BS
- Achkar B
- Adachi S
- Adam L
- Adamczyk L
- Adamek L
- Adelman J
- Adersberger M
- Adiguzel A
- Adorni S
- Adye T
- Affolder AA
- Afik Y
- Agapopoulou C
- Agaras MN
- Aggarwal A
- Agheorghiesei C
- Aguilar-Saavedra JA
- Ahmadov F
- Ahmed WS
- Ai X
- Aielli G
- Akatsuka S
- Akesson TPA
- Akilli E
- Akimov A
- Al Khoury K
- Alberghi GL
- Albert J
- Alderweireldt S
- Aleksa M
- Aleksandrov IN
- Alexa C
- Alexopoulos T
- Alfonsi A
- Alfonsi F
- Alhroob M
- Ali B
- Aliev M
- Alimonti G
- Allaire C
- Allbrooke BMM
- Allen BW
- Allport PP
- Aloisio A
- Alonso F
- Alpigiani C
- Alshehri AA
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- Alviggi MG
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- Ambler A
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- Zhemchugov A
- Zheng Z
- Zhong D
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- Zu Theenhausen HM
- Zwalinski L
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2015
- Field of study
Results of a search for new phenomena in final states with an energetic jet and large missing transverse momentum are reported. The search uses 20.3 fbâ1 of â s = 8 TeV data collected in 2012 with the ATLAS detector at the LHC. Events are required to have at least one jet with pT > 120 GeV and no leptons. Nine signal regions are considered with increasing missing transverse momentum requirements between Emiss T > 150 GeV and Emiss T > 700 GeV. Good agreement is observed between the number of events in data and Standard Model expectations. The results are translated into exclusion limits on models with either large extra spatial dimensions, pair production of weakly interacting dark matter candidates, or production of very light gravitinos in a gauge-mediated supersymmetric model. In addition, limits on the production of an invisibly decaying Higgs-like boson leading to similar topologies in the final state are presente
Performance of the CMS Cathode Strip Chambers with Cosmic Rays
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- Yumiceva F
- Yun JC
- Yuste C
- Zabi A
- Zabolotny W
- Zachariadou A
- Zalewski P
- Zampieri A
- Zanetti M
- Zang SL
- Zarubin A
- Zatzerklyany A
- Zeidler C
- Zeinali M
- Zeise M
- Zelepoukine S
- Zeuner WD
- Zeyrek M
- Zhang J
- Zhang L
- Zhang Y
- Zhang Z
- Zheng Y
- Zhiltsov V
- Zhokin A
- Zhu B
- Zhu K
- Zhu RY
- Zhukov V
- Zhukova V
- Ziebarth EB
- Zielinski M
- Zilizi G
- Zinonos Z
- Zito G
- Zoeller MH
- Zotto P
- Zub S
- Zumerle G
- Zuranski A
- Zuyeuski R
- Zych P
- Publication venue
- 'IOP Publishing'
- Publication date
- 01/01/2009
- Field of study
The Cathode Strip Chambers (CSCs) constitute the primary muon tracking device
in the CMS endcaps. Their performance has been evaluated using data taken
during a cosmic ray run in fall 2008. Measured noise levels are low, with the
number of noisy channels well below 1%. Coordinate resolution was measured for
all types of chambers, and fall in the range 47 microns to 243 microns. The
efficiencies for local charged track triggers, for hit and for segments
reconstruction were measured, and are above 99%. The timing resolution per
layer is approximately 5 ns
Pathogenic Huntingtin Repeat Expansions in Patients with Frontotemporal Dementia and Amyotrophic Lateral Sclerosis.
- Author
- Aarsland D
- Abramzon Y
- Adams DJ
- Adeleye A
- Aguilar M
- Ahmed S
- Al-Chalabi A
- Al-Sarraj S
- Al-Sarraj S
- Alba C
- Alba C
- Albani D
- Albert MS
- Altschuler S
- Alvarez I
- Amar K
- Ambrose JC
- Archibald N
- Arcila-Londono X
- Arepalli S
- Aronica E
- Arumugam P
- Asress S
- Atassi N
- Attems J
- Auluck P
- Baas F
- Baas F
- Babu S
- Bacikova D
- Bacikova D
- Baloh RH
- Baloh RH
- Bandmann O
- Baple EL
- Barrett MJ
- Beach TG
- Bekris LM
- Bennett DA
- Benussi L
- Berry JD
- Bertolin C
- Besser LM
- Bigio EH
- Binetti G
- Black SE
- Blair IP
- Bleda M
- Boada M
- Boardman-Pretty F
- Boeve BF
- Bohannan RC
- Boissiere JM
- Borroni B
- Boustred CR
- Bowser R
- Bowser R
- Boylan KB
- Brady CB
- Brett F
- Brice A
- Brice A
- Brittain H
- Broach J
- Broach JR
- Broce I
- Brown RH
- Brunetti M
- Bruni A
- Butovsky O
- Calini D
- Calvo A
- Camu W
- Canosa A
- Capps E
- Caraway CA
- Caroppo P
- Castellotti B
- Caulfield MJ
- Cereda C
- Ceroni M
- Chan GC
- Chandran S
- Chia R
- Chiang H-H
- ChiĂČ A
- ChiĂČ A
- Church A
- Clarimon J
- Clarimon J
- Coebergh J
- Colombrita C
- Comi GP
- Cooper-Knock J
- Corcia P
- Corrado L
- Corti S
- Costantini A
- Cox GA
- Craig CEH
- Crary J
- Critchley P
- Dalgard CL
- Danek A
- Danielson EW
- Dardiotis E
- Daugherty LC
- De Belleroche J
- De Burca A
- Del Bo R
- Devereau A
- Dewan R
- Dickson D
- Diehl-Schimd J
- Diekstra FP
- Diez-Fairen M
- Diez-Fairen M
- Ding J
- Dols-Icardo O
- Drepper C
- Drory V
- Drory VE
- Dubnau J
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- Dunckley TL
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- DâAlfonso S
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- Flanagan ME
- Floeter MK
- Floris G
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- Fortea J
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- Galimberti D
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- GarcĂa-Redondo A
- Gellera C
- Gentleman S
- Gerhard G
- Ghetti B
- Ghidoni R
- Ghosh BCP
- Gibbs JR
- Gibbs JR
- Gibson SB
- Gkazi AS
- Glass JD
- Goate A
- Goldstein D
- GonzĂĄlez-Aramburu I
- Gotkine M
- Goutman SA
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- Graff-Radford NR
- Hackett JM
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- Hamblin A
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- Hardy JA
- Harms M
- Harms MB
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- Hernandez DG
- HernĂĄndez I
- Hickman RA
- Hjermind LE
- Hodges AK
- Holman JE
- Hoover B
- Hornstein E
- Hu H-C
- Hu MTM
- Hubbard TJP
- Hupalo D
- Hupalo DN
- Ibåñez K
- IllĂĄn-Gala I
- Infante J
- Iranzo A
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- McDonagh EM
- McKeith I
- McKenna-Yasek D
- McLaughlin RL
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- Mesulam M-M
- Miller JW
- Miller TM
- Molina-Porcel L
- Monuki ES
- Mora G
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- Morris CM
- Morris HR
- Morris HR
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- Muñoz-Blanco JL
- Myllykangas L
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- Rogaeva E
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- Serpente M
- Serrano GE
- Shakkottai V
- Shalem O
- Shankaracharya FNU
- Sharma J
- Shaw CE
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- Shneider NA
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- Sidle KC
- Sidransky E
- Sieghart A
- Silani V
- Simmons Z
- Simmons Z
- Singleton AB
- Smedley D
- Smith BN
- Smith C
- Smith KR
- Soltis AR
- SorarĂč G
- Sorbi S
- Sosinsky A
- Spooner W
- Stefanis L
- Stein TD
- Stevens HE
- Stevic Z
- Stone DJ
- Stuckey A
- Sukumar G
- Sultana R
- Tagliavini F
- Talbot K
- Tanaka T
- Taroni F
- Tayebi N
- Ten Asbroek ALMA
- Thomas AJ
- Thomas ERA
- Thompson LM
- Thompson SR
- Ticozzi N
- Tienari PJ
- Tilley BS
- Tiloca C
- Topp SD
- Torkamani A
- Traynor BJ
- Tregidgo C
- Troakes C
- Troakes C
- Trojanowski JQ
- Troncoso JC
- Troncoso JC
- Tucci A
- Tuck M
- Turner MR
- Valori M
- Van Blitterswijk M
- Van Damme P
- Van Deerlin V
- Van den Berg LH
- Van Den Bosch L
- Van Rheenen W
- Vance C
- Vaughan J
- Veldink JH
- Viollet C
- Vonsattel JP
- Waldo ML
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- Walton RL
- Watters SA
- Welland MJ
- Wilkerson MD
- Williams E
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- Witkowska K
- Woltjer R
- Wood SM
- Wszolek ZK
- Wu L
- Wu Z
- Xiromerisiou G
- Zaitlen N
- Zarowiecki M
- Zecca C
- Zhang B
- Zhang X
- Zinman L
- Ăijerstedt L
- Publication venue
- Neuron
- Publication date
- 01/01/2020
- Field of study
We examined the role of repeat expansions in the pathogenesis of frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS) by analyzing whole-genome sequence data from 2,442 FTD/ALS patients, 2,599 Lewy body dementia (LBD) patients, and 3,158 neurologically healthy subjects. Pathogenic expansions (range, 40-64 CAG repeats) in the huntingtin (HTT) gene were found in three (0.12%) patients diagnosed with pure FTD/ALS syndromes but were not present in the LBD or healthy cohorts. We replicated our findings in an independent collection of 3,674 FTD/ALS patients. Postmortem evaluations of two patients revealed the classical TDP-43 pathology of FTD/ALS, as well as huntingtin-positive, ubiquitin-positive aggregates in the frontal cortex. The neostriatal atrophy that pathologically defines Huntington's disease was absent in both cases. Our findings reveal an etiological relationship between HTT repeat expansions and FTD/ALS syndromes and indicate that genetic screening of FTD/ALS patients for HTT repeat expansions should be considered
A922 Sequential measurement of 1 hour creatinine clearance (1-CRCL) in critically ill patients at risk of acute kidney injury (AKI)
- Author
- Abbott TE
- Abdallah RI
- Abdel-Aal IR
- Abdelmonem SA
- Abdo WF
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- Ahmadnia E
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- Ahn JY
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- Akcan-Arikan A
- Akhlagh SH
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- AKI Research Group
- Akiduki N
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- Alberto F
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- Aldana NN
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- Alhamdi Y
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- Altıntas ND
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- Amargianitakis V
- Amaro R
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- ARIAM registry of adult cardiac surgery
- ARIAM-ANDALUCIA
- Arias CC
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- CAPCRI Study
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- Chernyshuk S
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- Chhor V
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- Di Gravio V
- Di Gregorio A
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- Dimopoulou IK
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- Dominguez JP
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- Dorent R
- Dos Reis Miranda D
- Dos Santos HP
- Dougall PC
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- Doyle J
- Drover J
- Duarte R
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- Dubrawski A
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- Engelberts D
- ENVIN-HELICS Study Group
- Erb J
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- FINNRESUSCI Study Group
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- GETGAG Working Group
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- Japan Septic Disseminated Intravascular Coagulation (JSEPTIC DIC) study group
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- Jayasinghe S
- Jean-Baptiste S
- Jean-Baptiste S
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- Jensen JU
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- Joachim J
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- Jonas M
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- Joshi V
- Jovaisa T
- JSEPTIC (Japanese Society of Education for Physicians and Trainees in Intensive Care) Clinical Trial Group
- Juan WC
- Juanas CA
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- Juliarena A
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- Kwon WY
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- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2016
- Field of study
Meeting abstrac
Fatores associados ao excesso de peso em crianças brasileiras menores de cinco anos
- Author
- Abrantes MM
- Apfelbacher CJ
- Arenz S
- Balaban G
- Batista Filho M
- Chaparro MP
- Cora Luiza Pavin AraĂșjo
- Coutinho JG
- de Onis M
- Deitel M
- Dewey KG
- Dietz WH
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- Fernanda de Oliveira Meller
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- Guedes DP
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- Muller MJ
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- Perez-Pastor EM
- Pinheiro ARO
- Plachta-Danielzik S
- Samanta Winck Madruga2
- Shrewsbury V
- Twells L
- Victora CG
- Vieira MFA
- Vitolo MR
- Wang Y
- Weyermann M
- Zwiauer KF
- Zöllner CC
- Publication venue
- 'FapUNIFESP (SciELO)'
- Publication date
- Field of study
Combined measurement of differential and total cross sections in the HâŻââŻÎłÎł and the HâŻââŻZZ*âŻââŻ4â decay channels at s=13 TeV with the ATLAS detector
- Author
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- Asimakopoulou EM
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- Atkinson M
- Atlas Collaboration
- Atlay NB
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- Zhemchugov A
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- Zimmermann S
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- ĆœivkoviÄ L
- Publication venue
- Elsevier
- Publication date
- 01/01/2018
- Field of study
A combined measurement of differential and inclusive total cross sections of Higgs boson production is performed using 36.1 fbâ1 of 13 TeV protonâproton collision data produced by the LHC and recorded by the ATLAS detector in 2015 and 2016. Cross sections are obtained from measured Hâγγ and HâZZ*(â4â event yields, which are combined taking into account detector efficiencies, resolution, acceptances and branching fractions. The total Higgs boson production cross section is measured to be 57.0â5.9 +6.0 (stat.) â3.3 +4.0 (syst.) pb, in agreement with the Standard Model prediction. Differential cross-section measurements are presented for the Higgs boson transverse momentum distribution, Higgs boson rapidity, number of jets produced together with the Higgs boson, and the transverse momentum of the leading jet. The results from the two decay channels are found to be compatible, and their combination agrees with the Standard Model predictions
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