205 research outputs found
Establishment of a doxycycline-regulated cell line with inducible, doubly-stable expression of the wild-type p53 gene from p53-deleted hepatocellular carcinoma cells
- Publication venue
- BioMed Central
- Publication date
- 01/01/2005
- Field of study
p53 is important in the development of hepatocellular carcinoma (HCC) and in therapeutic approaches, but the mechanism whereby it inhibits HCC growth is still unclear. The aim of the present study was to establish a HCC cell system in which p53 levels can be regulated. Full-length wild-type p53 cDNA obtained by PCR was cloned into a retroviral response vector controlled by the tetracycline responsive element (RevTRE-p53). The regulatory vectors RevTet-Off and RevTRE-p53 were transfected into a packaging cell line, PT67. Hep3B cells in which the p53 gene was deleted were infected with RevTet-Off viral particles from the PT67. Three G418-resistant cell clones with high luciferase expression and low background were infected with RevTRE-p53. By screening dozens of RevTRE-p53-infected clones with hygromycin we identified the one with the highest expression of p53 and the lowest background after doxycycline treatment. The results showed that p53 expression in this cell clone could be simply turned on or off by removing or adding doxycycline. Furthermore, it was found that the level of p53 protein was negatively and sensitively related to the doxycycline concentration. In conclusion, we have established a HCC cell line in which p53 expression can be switched on or off and regulated in a dose- and time-dependent manner
Reply to: Comment on: 'Long-term impact of liver function on curative therapy for hepatocellular carcinoma: application of the ALBI grade'
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 23/06/2016
- Field of study
Enhanced detection of early hepatocellular carcinoma by serum SELDI-TOF proteomic signature combined with alpha-fetoprotein marker.
- Author
- Publication venue
- Ann Surg Oncol
- Publication date
- 01/01/2010
- Field of study
BACKGROUND: Biomarkers for accurate diagnosis of early hepatocellular carcinoma (HCC) are limited in number and clinical validation. We applied SELDI-TOF-MS ProteinChip technology to identify serum profile for distinguishing HCC and liver cirrhosis (LC) and to compare the accuracy of SELDI-TOF-MS profile and alpha-fetoprotein (AFP) level in HCC diagnosis. PATIENTS AND METHODS: Serum samples were obtained from 120 HCC and 120 LC patients for biomarker discovery and validation studies. ProteinChip technology was employed for generating SELDI-TOF proteomic features and analyzing serum proteins/peptides. RESULTS: A diagnostic model was established by CART algorithm, which is based on 5 proteomic peaks with m/z values at 3324, 3994, 4665, 4795, and 5152. In the training set, the CART algorithm could differentiate HCC from LC subjects with a sensitivity and specificity of 98% and 95%, respectively. The results were assessed in blind validation using separate cohorts of 60 HCC and 60 LC patients, with an accuracy of 83% for HCC and 92% for LC patients. The diagnostic odd ratio (DOR) indicated that SELDI-TOF proteomic signature could achieve better diagnostic performance than serum AFP level at a cutoff of 20 ng/mL (AFP(20)) (92.72 vs 9.11), particularly superior for early-stage HCC (87% vs 54%). Importantly, a combined use of both tests could enhance the detection of HCC (sensitivity, 95%; specificity, 98%; DOR, 931). CONCLUSION: Serum SELDI-TOF proteomic signature, alone or in combination with AFP marker, promises to be a good tool for early diagnosis and/screening of HCC in at-risk population with liver cirrhosis
Prognostic values of EORTC QLQ-C30 and QLQ-HCC18 index-scores in patients with hepatocellular carcinoma â clinical application of health-related quality-of-life data
- Author
- Annette NY Poon
- Anthony TC Chan
- AS Lok
- Brigette BY Ma
- CC Gotay
- Cheuk M Chu
- DF Cella
- Edwin P Hui
- F Bonnetain
- FE Harrell Jr
- Frankie KF Mo
- J Ho
- Jane Koh
- JM Blazeby
- Joyce Hui
- K Steen Van
- Kit F Lee
- Leung Li
- Linda KS Leung
- M Diouf
- M Diouf
- N Mikoshiba
- Nelson SL Tang
- NK Aaronson
- Paul BS Lai
- PL Chin
- R Fielding
- Simon CH Yu
- Stephen L Chan
- W Yeo
- WC Chie
- Winnie Yeo
- WO Spitzer
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Global patient outcomes after elective surgery: prospective cohort study in 27 low-, middle- and high-income countries.
- Author
- Ab Majid MA
- Ab Rahman AS
- Ab Rahman R
- Abayasinghe C
- Abbott T
- Abdullah NH
- Abdur-Rahman L
- Abeloos J
- Abernethy C
- Abidin UN
- Abrunhosa A
- Absar M
- Adam S
- Adams D
- Adams G
- Adamson M
- Adekola O
- Adelaja Y
- Ademola A
- Adenekan A
- Adenike O
- Adeolu AA
- Adetoye A
- Adewale B
- Adigun T
- Adolfsson A
- Aflori L
- Africander C
- Afshari A
- Agarwal V
- Agodirin O
- Aguero Vera M
- Aguzzoli C
- Ahmad A
- Ahmad N
- Ahmad T
- Ahmad T
- Ahmad Y
- Ahmed A
- Ahmed J
- Ai Y
- Aignatoaie M
- Aimoniotou-Georgiou E
- Akanmu O
- Akerman N
- Akinwale M
- Akring I
- Al 'Amri K
- Al Anizi M
- Al hussaini S
- Al-Soudaine Y
- Aladin H
- Alagbe-Briggs O
- Alaman Laguarda G
- Albaj S
- Alcock D
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- Aldecoa C
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- Aleixo FB
- Alexander H
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- Alherz F
- Ali H
- Ali M
- Ali S
- Alias A
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- Alias RLR
- Alit MA
- Allen S
- Allen SJ
- Allison J
- Alloj C
- Allorto NL
- Allsop J
- Almeida W
- Alonso E
- Alphonsus C
- Alvares D
- Alves MJ
- Amador JCB
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- Amendola CP
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- Aquino LPG
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- Arawwawala D
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- Publication venue
- 'Oxford University Press (OUP)'
- Publication date
- 01/01/2016
- Field of study
BACKGROUND: As global initiatives increase patient access to surgical treatments, there remains a need to understand the adverse effects of surgery and define appropriate levels of perioperative care. METHODS: We designed a prospective international 7-day cohort study of outcomes following elective adult inpatient surgery in 27 countries. The primary outcome was in-hospital complications. Secondary outcomes were death following a complication (failure to rescue) and death in hospital. Process measures were admission to critical care immediately after surgery or to treat a complication and duration of hospital stay. A single definition of critical care was used for all countries. RESULTS: A total of 474 hospitals in 19 high-, 7 middle- and 1 low-income country were included in the primary analysis. Data included 44Â 814 patients with a median hospital stay of 4 (range 2-7) days. A total of 7508 patients (16.8%) developed one or more postoperative complication and 207 died (0.5%). The overall mortality among patients who developed complications was 2.8%. Mortality following complications ranged from 2.4% for pulmonary embolism to 43.9% for cardiac arrest. A total of 4360 (9.7%) patients were admitted to a critical care unit as routine immediately after surgery, of whom 2198 (50.4%) developed a complication, with 105 (2.4%) deaths. A total of 1233 patients (16.4%) were admitted to a critical care unit to treat complications, with 119 (9.7%) deaths. Despite lower baseline risk, outcomes were similar in low- and middle-income compared with high-income countries. CONCLUSIONS: Poor patient outcomes are common after inpatient surgery. Global initiatives to increase access to surgical treatments should also address the need for safe perioperative care. STUDY REGISTRATION: ISRCTN5181700
A922 Sequential measurement of 1 hour creatinine clearance (1-CRCL) in critically ill patients at risk of acute kidney injury (AKI)
- Author
- Abbott TE
- Abdallah RI
- Abdel-Aal IR
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- Granada RM
- Granados PR
- Grando M
- Granger CL
- Grangé S
- Grangé S
- Grangé S
- Granillo JF
- Grassi L
- Grasso S
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- Green RS
- Greer M
- Gregory S
- Grelon F
- Grelon F
- Grelon F
- Grevelink M
- Grossestreuer A
- Guanziroli M
- Guarracino F
- Guarracino F
- Gubianas CM
- Guerrero AP
- Guerrero JE
- Guerrero-Lopez F
- Guerrero-LĂłpez F
- Guervilly C
- Guidet B
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- Guillen JA
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- Gul F
- Gupta A
- Gupta D
- Gupta O
- Gustad LT
- Gutierrez LA
- Gutiérrez-Pizarraya A
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- GĂĄlvez V
- GĂ©ri G
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- Gómez-Jiménez C
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- Haines R
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- Haritydi T
- Harm S
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- Hayakawa M
- Hayakawa M
- Hayakawa M
- Hayakawa M
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- Healey AJ
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- Henderson MA
- Hendra H
- Henschel B
- Heras G
- Hernandis V
- HernĂĄndez A
- HernĂĄndez AA
- HernĂĄndez AA
- HernĂĄndez AA
- HernĂĄndez AA
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- HernĂĄndez AA
- HernĂĄndez G
- HernĂĄndez-Tejedor A
- Herpain A
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- Herrera AN
- Herrera AN
- Herrera AN
- Herrera AN
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- Heunks LM
- Hewitt H
- Heyne T
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- Hidalgo C
- Hikasa Y
- Hillier SD
- Himmel Y
- Himpe D
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- Hirata A
- Hirayama T
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- Hodgson LE
- Hodgson LE
- Hofmeijer J
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- Hoppu S
- Hoppu S
- Horkan CM
- Horstmann C
- Horton A
- Horvat A
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- Houzé S
- Houzé S
- Howes D
- Hozhabri K
- Hrachovina M
- Hraiech S
- Hravnak M
- Hu HC
- Hua Y
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- Hualde JB
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- Hualde JB
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- Huang CH
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- Huang WC
- Hubbard A
- Huber W
- Huddart S
- Hull AM
- Hung CY
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- Huot B
- Husheer SL
- Hutchings S
- Hutchison R
- Hwang GS
- Hwang GS
- Ibañes PG
- Ibsen M
- Idei M
- Idei M
- Idone FA
- Iesu E
- Iesu E
- Iglesias-Santiago A
- Ignacio ML
- Iida A
- Iijima H
- Ilan R
- Ilyina V
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- IPREA Study Group
- Irazabal JM
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- Itenov TS
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- Jacobs FM
- Jacques T
- Jaffal K
- Jamali S
- Jang BH
- Janotka M
- Janotka M
- Janotka M
- Jansen D
- Jansen N
- Japan Septic Disseminated Intravascular Coagulation (JSEPTIC DIC) study group
- Jardim JJ
- Jardim M
- Jareño A
- Javadpour S
- Jayasinghe S
- Jean-Baptiste S
- Jean-Baptiste S
- Jensen AE
- Jensen JU
- Jeon YD
- Jeon YD
- Jeong IY
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- Jian Z
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- Jibaja M
- Jimenez-Herrera MF
- Jiménez GJ
- Jo YH
- Joachim J
- Jochmans S
- John G
- Jonas M
- Jonas M
- Jonas M
- Jones C
- Joshi R
- Joshi V
- Jovaisa T
- JSEPTIC (Japanese Society of Education for Physicians and Trainees in Intensive Care) Clinical Trial Group
- Juan WC
- Juanas CA
- Judickas S
- Juez A
- Juliarena A
- Jun IG
- Jun IG
- Jung K
- Jung KW
- Junior JM
- Kaczirek K
- Kaese S
- Kalani N
- Kalenka A
- Kalfon P
- Kamali E
- Kaminsky GE
- Kaneko M
- Kang M
- Kang M
- Kang PL
- Kang PL
- Kang PL
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- Kang Y
- Kao KC
- Kappler F
- Kara A
- Karachi F
- Karanjia N
- Karbing DS
- Karsten E
- Kasdan H
- Kashiya S
- Kashyap R
- Katabami K
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- Katabami K
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- Katira BH
- Kavanagh BP
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- Kawano S
- Kay FU
- Kayaaslan B
- Kayambu G
- Kazutoshi F
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- Kellner F
- Kelly JM
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- Keough E
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- Kerr C
- Kezyte G
- Khadjibaev A
- Khaliq W
- Khine H
- Kim DJ
- Kim HJ
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- Kim KS
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- Kim MH
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- Kim W
- Kimmoun A
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- Kinnear J
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- Kirakli C
- Kirca H
- Kirman M
- Kirwan CJ
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- Klaus DA
- Kleinpell R
- Kluge S
- Knafelj R
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- Ko JI
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- Kobayashi A
- Koco E
- Kodate A
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- Kokkini S
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- Komuro T
- Kondili E
- Kongpolprom N
- Kooner G
- Kostalas M
- Kosuk ME
- Kotsopoulos A
- Kou PS
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- Kovacikova L
- Kox M
- Kraegpoeth A
- Krenn CG
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- Kristof J
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- Kubota K
- Kuebler WM
- Kulaga EV
- Kulkarni AP
- Kumari BK
- Kumbamu A
- Kunze-Szikszay N
- Kurmukov IA
- Kurth T
- Kurtz P
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- Kwon HM
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- Kye YC
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- Labaune MA
- Labra C
- Lacerda P
- Laerkner E
- Lafaurie M
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- Lagonidis D
- Lagos R
- Lahmer T
- Lai CC
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- Larsson JS
- Latini R
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- Latorre J
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- Lawrence N
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- Leite RT
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- Leone M
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- Lerma FA
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- Lichtenstein D
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- Lin KC
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- Lischinsky A
- Lissonde F
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- Lobo-Civico A
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- Lukaszewicz AC
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- MacKay A
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- MacPhee I
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- Maghsoudi B
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- Merino-Vega D
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- Muhammad JB
- Mukherjee DN
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- Okayama Research Investigation Organizing Network (ORION)investigators
- Olaechea P
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- Prazeres PH
- Preau S
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- Wijayatilake DS
- Wildenberg L
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- WIND study group
- Winder-Rhodes S
- Witter T
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- Yamazaki A
- Yan WW
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- Yang YL
- Yasuda H
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- Yebenes JC
- Yeh YC
- Yemets H
- Yergaliyeva A
- Yılmaz G
- Yilmazer F
- Yodice P
- Yokoyama M
- Yonis H
- Yonis H
- Yonis H
- Yoon SZ
- Yoruk F
- Yoshida K
- Yoshida T
- Yoshida T
- Yoshida T
- Yoshida T
- Yoshihiro S
- Yoshitake E
- You KM
- Youn AM
- Young A
- Yu KM
- Yumoto T
- Yuzawa J
- Yuzawa J
- Zabaletta WJ
- Zabini D
- Zahorec M
- Zaien I
- Zakynthinos S
- Zanello M
- Zani D
- Zarantonello F
- Zayas B
- Zepeda EM
- Zeroual N
- Zerva L
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- Zhovnir V
- Zibandah N
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- Zwaag J
- ZĂœkovĂĄ I
- Ălvarez JT
- Ălvarez-Lerma F
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2016
- Field of study
Meeting abstrac
Multi-messenger observations of a binary neutron star merger
- Author
- Aab A
- Aartsen MG
- Abbott BP
- Abbott R
- Abbott TD
- Abbott TMC
- Abdalla H
- Abe F
- Abeysekara AU
- Abramo LR
- Abramowski A
- Abreu P
- Acernese F
- Acero F
- Ackermann M
- Ackley K
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- Agliozzo C
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- Aharonian F
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- Al Samarai I
- Albert A
- Albert A
- Albuquerque IFM
- Albury JM
- Alcaniz JS
- Alexander KD
- Alfaro R
- Alighieri S Di Serego
- Allam S
- Allekotte I
- Allen B
- Allen G
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- Allocca A
- Almela A
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- Altmann D
- Alvarez C
- Alvarez JD
- Alvarez M Dovale
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- Amati L
- Amato A
- An T
- Ananyeva A
- Anastasi GA
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- Andreoni I
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- Anghinolfi M
- Angner EO
- Angus CR
- Annis J
- Ansseau I
- Antier S
- Anton G
- Antonelli LA
- Antonelli LA
- Anupama GC
- Aoki K
- Aoki W
- Appert S
- Aptekar RL
- Arai K
- Arakawa M
- Aramo C
- Araya MC
- Arcavi I
- Arceo R
- Ardid M
- Areeda JS
- Aresu G
- Argan A
- Argelles C
- Arnaud N
- Array LWA Long Wavelength
- Array MWA Murchison Widefield
- Arrieta M
- Arsene N
- Arteaga-Velzquez JC
- Artola R
- Arun KG
- Asakura Y
- Asaoka Y
- Ascenzi S
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- ATLAS
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- Blackburn JK
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- Blair CD
- Blair DG
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- Blaufuss E
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- Bleve C
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- Bloom ED
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- Bock O
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- Boer M
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- Bohe A
- Bohm C
- Boisson C
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- Bond IA
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- Bonnefoy S
- Bonoli S
- Booler T
- Boom BA
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- Bos F
- Boschi V
- Bose D
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- Botti AM
- Botticella MT
- Bouffanais Y
- Bourbeau E
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- Bourret S
- Bouwhuis MC
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- Brack J
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- Bradascio F
- Brady PR
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- Brau JE
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- Brayeur L
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- Bregeon J
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- Buckley-Geer E
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- CALTECH GROWTH JAGWAR
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- Camilo F
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- Cao XL
- Capaccioli M
- Capano CD
- Capasso M
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- Capocasa E
- Capone A
- Capozzi D
- Cappellaro E
- Caputo R
- Caramete L
- Caraveo P
- Caraveo PA
- Carbognani F
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- Cardenas B Vargas
- Cardillo M
- Caria T
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- Carlin JL
- Carney MF
- Caroff S
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- Carramiana A
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- Casasola V
- Casella P
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- Castillo J Alvarez
- Castillo M
- Castro JM Gonzalez
- Castro ML Diaz
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- Chatterjee D
- Chatterjee D
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- Chaves RCG
- Chavez AG
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- Cheeseboro BD
- Chekhtman A
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- Cherry ML
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- Cheung E
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- Chiummo A
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- Cho HS
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- Chow JH
- Christensen N
- Christov A
- Chu Q
- Chua AJK
- Chua S
- Chudoba J
- Chung AKW
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- Cikota A
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- Cirelli CE
- Cirone A
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- Clearwater P
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- Li X
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- Li XB
- Li XF
- Li YG
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- Pan-STARRS
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- Pandya H
- Paneque D
- Pang B
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- Pannarale F
- Pant BC
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- Parmiggiani N
- Parra A
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- Pasqualetti A
- Passaquieti R
- Passuello D
- Pastorello A
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- Pavalas GE
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- Pea-Rodriguez J
- Pearlstone BL
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- Pekeur NW
- Pekowsky L
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- Piccinni OJ
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- Picozza P
- Piel Q
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- Piergiovanni F
- Pierog T
- Pierro V
- Pignata G
- Pike S
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- Pillant G
- Pimenta M
- Pinard L
- Pinat E
- Pinto IM
- Piotrowski LW
- Piran T
- Piran T
- Piranomonte S
- Pirello M
- Piro AL
- Piro L
- Piron F
- Pirronello V
- Pisanu T
- Pita S
- Pitkin M
- Pittori C
- Placco VM
- Platino M
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- Podesta F
- Podesta RC
- Podsiadlowski P
- Poe M
- Poggiani R
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- Poireau V
- Pollmann A Obertacke
- Poolakkil S
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- Popolizio P
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- Possenti A
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- Pozanenko AS
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- Prado RR
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- Principe G
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- Privitera P
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- Prochaska JX
- Prodi GA
- Prokhorov D
- Prokhorov LG
- Prokoph H
- Prouza M
- Prrer M
- Przybylski GT
- Pulone L
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- Quimby RM
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- Reimer A
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- Ren Z
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- Renzi V
- Reposeur T
- Resconi E
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- Robie R
- Robinet F
- Rocchi A
- Rochester LS
- Rodi J
- Rodriguez H
- Rojas D Avila
- Rojas-Bravo C
- Rojo J Rodriguez
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- Rollins JG
- Roma VJ
- Romano R
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- Romer AK
- Romero M Dominguez
- Romie JH
- Romoli C
- Roncoroni MJ
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- Rosell A Carnero
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- Rosswog S
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- Ruiz R Gracia
- Ruiz-Velasco E
- Rulten CB
- Rumyantsev VV
- Rusu F
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- Rybicki KA
- Ryckbosch D
- Rykoff ES
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- Sadecki T
- Sadeghian L
- Sadler EM
- Sadler EM
- Saffe C
- Saffi SJ
- Saftoiu A
- Sahakian V
- Sai N
- Saito S
- Saito T
- Saito Y
- Sakamaki A
- Sakamoto T
- Sakellariadou M
- Sako M
- Sako S
- Salafia OS
- Salamida F
- Salazar H
- Salazar H
- Salconi L
- Saldaa M
- Saleem M
- Saleh A
- Salemi F
- Salina G
- Salmon L
- Salvadori I
- Salvaterra R
- Samajdar A
- Sammut L
- Sampedro L
- Sampson LM
- Samtleben DFE
- Sanchez B
- Sanchez DA
- Sanchez E
- Sanchez EJ
- Sanchez F
- Sanchez LE
- Sanchez-Losa A
- Sanchez-Lucas P
- Sanchez-Ramirez R
- Sanchis-Gual N
- Sand DJ
- Sandberg V
- Sanders JR
- Sandoval A
- Sandrock A
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- Sansom EK
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- Santangelo A
- Santos E
- Santos EM
- Sapienza P
- Sarazin F
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- Sasaki M
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- Satalecka K
- Sathyaprakash BS
- Sato R
- Saulson PR
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- Sauter O
- Savage RL
- Savchenko V
- Sawadsky A
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- Schlegel DJ
- Schlickeiser R
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- Schmidt BP
- Schmidt D
- Schmidt J
- Schmidt P
- Schmidt T
- Schnabel R
- Schneider A
- Schneider M
- Schneiter M
- Schoenell W
- Schoenen S
- Schofield RMS
- Scholten O
- Schonbeck A
- Schoneberg S
- Schoorlemmer H
- Schovnek P
- Schreiber E
- Schroder FG
- Schroder S
- Schroder SL
- Schssler F
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- Schuette D
- Schulte BW
- Schultz ASB
- Schulz A
- Schulz A
- Schulze S
- Schumacher J
- Schumacher L
- Schutz BF
- Schwalbe SG
- Schwanke U
- Schwemmer S
- Schweyer T
- Sciutto SJ
- Scolnic D
- Scott J
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- Secco LF
- Seckel D
- Seglar-Arroyo M
- Segreto A
- Seidel E
- Seitenzahl IR
- Sekiguchi Y
- Sellers D
- Selsing J
- Sengupta AS
- Sentenac D
- Sequino V
- Sergeev A
- Sergienko Yu P
- Serino M
- Serra G
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- Serrau M
- Settimo M
- Seunarine S
- Sevilla-Noarbe I
- Seyffert AS
- Sgro C
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- Shadkam A
- Shaffer TJ
- Shafi N
- Shah AA
- Shahriar MS
- Shaner MB
- Shang Z
- Shannon RM
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- Shappee BJ
- Shara MM
- Sharma I
- Sharp RG
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- Sheldon E
- Shellard RC
- Sheperd A
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- Shilon I
- Shimizu Y
- Shimomukai R
- Shingles LJ
- Shiningayamwe K
- Shoemaker DH
- Shoemaker DM
- Shulevski A
- Siebert MR
- Siegel MH
- Sieger C
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- Siemens X
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- Singer LP
- Singh A
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- Sintes AM
- Siskind EJ
- Slagmolen BJJ
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- Smartt SJ
- Smida R
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- Starling RLC
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- Steele I
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- Stone R
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- Stosl A
- Strafella F
- Strain KA
- Stratta G
- Streich A
- Strigin SE
- Strotjohann NL
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- Publication venue
- 'American Astronomical Society'
- Publication date
- 01/01/2017
- Field of study
On 2017 August 17 a binary neutron star coalescence candidate (later designated GW170817) with merger time 12:41:04 UTC was observed through gravitational waves by the Advanced LIGO and Advanced Virgo detectors. The Fermi Gamma-ray Burst Monitor independently detected a gamma-ray burst (GRB 170817A) with a time delay of ~1.7 s with respect to the merger time. From the gravitational-wave signal, the source was initially localized to a sky region of 31 deg2 at a luminosity distance of 40+8-8 Mpc and with component masses consistent with neutron stars. The component masses were later measured to be in the range 0.86 to 2.26 Mo. An extensive observing campaign was launched across the electromagnetic spectrum leading to the discovery of a bright optical transient (SSS17a, now with the IAU identification of AT 2017gfo) in NGC 4993 (at ~40 Mpc) less than 11 hours after the merger by the One- Meter, Two Hemisphere (1M2H) team using the 1 m Swope Telescope. The optical transient was independently detected by multiple teams within an hour. Subsequent observations targeted the object and its environment. Early ultraviolet observations revealed a blue transient that faded within 48 hours. Optical and infrared observations showed a redward evolution over ~10 days. Following early non-detections, X-ray and radio emission were discovered at the transientâs position ~9 and ~16 days, respectively, after the merger. Both the X-ray and radio emission likely arise from a physical process that is distinct from the one that generates the UV/optical/near-infrared emission. No ultra-high-energy gamma-rays and no neutrino candidates consistent with the source were found in follow-up searches. These observations support the hypothesis that GW170817 was produced by the merger of two neutron stars in NGC4993 followed by a short gamma-ray burst (GRB 170817A) and a kilonova/macronova powered by the radioactive decay of r-process nuclei synthesized in the ejecta
Large expert-curated database for benchmarking document similarity detection in biomedical literature search
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- Publication venue
- OXFORD UNIV PRESS
- Publication date
- 29/10/2019
- Field of study
Document recommendation systems for locating relevant literature have mostly relied on methods developed a decade ago. This is largely due to the lack of a large offline gold-standard benchmark of relevant documents that cover a variety of research fields such that newly developed literature search techniques can be compared, improved and translated into practice. To overcome this bottleneck, we have established the RElevant LIterature SearcH consortium consisting of more than 1500 scientists from 84 countries, who have collectively annotated the relevance of over 180 000 PubMed-listed articles with regard to their respective seed (input) article/s. The majority of annotations were contributed by highly experienced, original authors of the seed articles. The collected data cover 76% of all unique PubMed Medical Subject Headings descriptors. No systematic biases were observed across different experience levels, research fields or time spent on annotations. More importantly, annotations of the same document pairs contributed by different scientists were highly concordant. We further show that the three representative baseline methods used to generate recommended articles for evaluation (Okapi Best Matching 25, Term FrequencyâInverse Document Frequency and PubMed Related Articles) had similar overall performances. Additionally, we found that these methods each tend to produce distinct collections of recommended articles, suggesting that a hybrid method may be required to completely capture all relevant articles. The established database server located at https://relishdb.ict.griffith.edu.au is freely available for the downloading of annotation data and the blind testing of new methods. We expect that this benchmark will be useful for stimulating the development of new powerful techniques for title and title/abstract-based search engines for relevant articles in biomedical research
First measurement of the |t|-dependence of coherent J/Ï photonuclear production
- Author
- Acharya S
- Acosta FT
- Adam J
- Adamova D
- Adler A
- Adolfsson J
- Aggarwal MM
- Agnello M
- Agrawal N
- Ahammed Z
- Ahn SU
- Aiola S
- Akindinov A
- Al-Turany M
- Alam SN
- Albuquerque DSD
- Aleksandrov D
- Alessandro B
- Alfanda HM
- Alfaro Molina R
- Ali Y
- Alici A
- Alkin A
- Alme J
- Alt T
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- Altsybeev I
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- Willems GA
- Williams MCS
- Willsher E
- Windelband B
- Witt WE
- Xu R
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- Yamakawa K
- Yano S
- Yin Z
- Yokoyama H
- Yoo I-K
- Yoon JH
- Yuan S
- Yurchenko V
- Zaccolo V
- Zaman A
- Zampolli C
- Zanoli HJC
- Zardoshti N
- Zarochentsev A
- Zavada P
- Zaviyalov N
- Zbroszczyk H
- Zhalov M
- Zhang X
- Zhang Y
- Zhang Z
- Zhao C
- Zherebchevskii V
- Zhigareva N
- Zhou D
- Zhou Y
- Zhou Z
- Zhu H
- Zhu J
- Zhu Y
- Zichichi A
- Zimmermann MB
- Zinovjev G
- Zmeskal J
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2021
- Field of study
The first measurement of the cross section for coherent J/Ï photoproduction as a function of |t|, the square of the momentum transferred between the incoming and outgoing target nucleus, is presented. The data were measured with the ALICE detector in ultra-peripheral PbâPb collisions at a centre-of-mass energy per nucleon pair sNN=5.02TeV with the J/Ï produced in the central rapidity region |y|<0.8, which corresponds to the small Bjorken-x range (0.3â1.4)Ă10â3.
The measured |t|-dependence is not described by computations based only on the Pb nuclear form factor, while the photonuclear cross section is better reproduced by models including shadowing according to the leading-twist approximation, or gluon-saturation effects from the impact-parameter dependent BalitskyâKovchegov equation. These new results are therefore a valid tool to constrain the relevant model parameters and to investigate the transverse gluonic structure at very low Bjorken-x.publishedVersio
First measurement of coherent Ï0 photoproduction in ultra-peripheral XeâXe collisions at âsNN = 5.44 TeV
- Author
- Acharya S
- Adamova D
- Adler A
- Adolfsson J
- Agnello M
- Agrawal N
- Ahammed Z
- Ahmad S
- Ahn SU
- Akbar Z
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- Albuquerque DSD
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- Szabo A
- Szarka I
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- Tambave GJ
- Tang S
- Tang Z
- Tarhini M
- Tarzila MG
- Tauro A
- Tejeda Munoz G
- Telesca A
- Terlizzi L
- Terrevoli C
- Tersimonov G
- Thakur S
- Thomas D
- Tieulent R
- Tikhonov A
- Timmins AR
- Tkacik M
- Toia A
- Topilskaya N
- Toppi M
- Torales-Acosta F
- Torres SR
- Trifiro A
- Tripathy S
- Tripathy T
- Trogolo S
- Trombetta G
- Tropp L
- Trubnikov V
- Trzaska WH
- Trzcinski TP
- Trzeciak BA
- Tumkin A
- Turrisi R
- Tveter TS
- Ullaland K
- Umaka EN
- Uras A
- Urioni M
- Usai GL
- Uysal A Karasu
- Vala M
- Valle N
- Vallero S
- van der Kolk N
- van Doremalen LVR
- van Leeuwen M
- Vande Vyvre P
- Varga D
- Varga Z
- Varga-Kofarago M
- Vargas A
- Vasileiou M
- Vasiliev A
- Vechernin V
- Vercellin E
- Vergara Limon S
- Vermunt L
- Vertesi R
- Verweij M
- Vickovic L
- Vilakazi Z
- Vino G
- Vinogradov A
- Virgili T
- Vislavicius V
- Vodopyanov A
- Voelkl MA
- Volkel B
- Voloshin K
- Voloshin SA
- Volpe G
- von Haller B
- Vorobyev I
- Voscek D
- Vrlakova J
- Wagner B
- Weber M
- Wegrzynek A
- Wenzel SC
- Wessels JP
- Wiechula J
- Wikne J
- Wilk G
- Wilkinson J
- Willems GA
- Willsher E
- Windelband B
- Winn M
- Witt WE
- Wright JR
- Wu Y
- Xu R
- Yalcin S
- Yamaguchi Y
- Yamakawa K
- Yang S
- Yano S
- Yin Z
- Yokoyama H
- Yoo I-K
- Yoon JH
- Yuan S
- Yuncu A
- Yurchenko V
- Zaccolo V
- Zaman A
- Zampolli C
- Zanoli HJC
- Zardoshti N
- Zarochentsev A
- Zavada P
- Zaviyalov N
- Zbroszczyk H
- Zhalov M
- Zhang S
- Zhang X
- Zhang Y
- Zherebchevskii V
- Zhi Y
- Zhou D
- Zhou Y
- Zhu J
- Zhu Y
- Zichichi A
- Zinovjev G
- Zurlo N
- Publication venue
- 'Elsevier BV'
- Publication date
- 28/12/2020
- Field of study
The first measurement of the coherent photoproduction of Ï0 vector mesons in ultra-peripheral XeâXe collisions at sNN=5.44 TeV is presented. This result, together with previous HERA Îłp data and ÎłâPb measurements from ALICE, describes the atomic number (A) dependence of this process, which is particularly sensitive to nuclear shadowing effects and to the approach to the black-disc limit of QCD at a semi-hard scale. The cross section of the Xe+XeâÏ0+Xe+Xe process, measured at midrapidity through the decay channel Ï0âÏ+Ïâ, is found to be dÏ/dy=131.5±5.6(stat.)â16.9+17.5(syst.) mb. The ratio of the continuum to resonant contributions for the production of pion pairs is also measured. In addition, the fraction of events accompanied by electromagnetic dissociation of either one or both colliding nuclei is reported. The dependence on A of cross section for the coherent Ï0 photoproduction at a centre-of-mass energy per nucleon of the ÎłA system of WÎłA,n=65 GeV is found to be consistent with a power-law behaviour Ï(ÎłAâÏ0A)âAα with a slope α=0.96±0.02(syst.). This slope signals important shadowing effects, but it is still far from the behaviour expected in the black-disc limit.publishedVersio
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