Urban greenways planning. A vision plan for Milan (Italy)

Greenways are “green infrastructure” to link people and places (Fabos, 1995) and can be planned at different scales (from national to municipal) and for multiple purposes, “including ecological, recreational, cultural, aesthetic” (Ahern, 1995), “to provide people with access to open spaces close to where they live” (President\u27s Commission on Americans Outdoors, 1987), in order to “enhance both the environment and quality of life” (European Greenways Association, 2000). At the municipal scale, the urban greenways network can help to reshape the city, making it more livable; urban greenways represent “at once the parks for the 21st century and a part of the transportation infrastructure, providing for pleasant, efficient, healthful and environmentally-sound travel by foot, bicycle or skates” (New York City Department of City Planning, 1993). Turner (2006) reported the results of a research conducted in 2001 among the British local authorities, in which come out the different purpose of urban greenway planning: creating a coherent (green) network of public open spaces, creating a green transport network that confers a vital new use on public open spaces, contributing to the reintegration of planning for ‘town’ and ‘country’ in order to serve the needs of a new urban population seeking active recreation in the countryside. The most important benefits of greenways in urban areas are environmental protection, recreation, and alternative transportation. These benefits cannot be realized unless the greenway planners take a systematic approach to the delineation of greenway paths (Conine et al., 2004). Various methodologies for greenways planning that take into account the many factors in a cohesive manner have been developed for and successfully applied, such as those described in Flink and Searns (1993), Smith and Hellmund (1993), Fabos (1995), Tzolova (1995), Xiang (1996), Toccolini et al. (2004), Ribeiro and Barao (2006) and Toccolini et al. (2006). In the present study three significant experiences were analyzed more in depth: New York City (New York City Department of City Planning, 1993), Vancouver (City of Vancouver, 1995) and Brussels (Institut Bruxellois pour la Gestion de l’Environnement, 2001). There has always been a strong link between the city of New York and the Greenways; as a matter of fact it is right here where it was first conceived the first plan of the modern age concerning a network of urban greenways (in 1866, with the Parkways designed by Frederick Law Olmsted and Calvert Vaux). Over the years, the great metropolis has preserved this link and recently this link has led to a plan of Greenways for the city. The plan was proposed in 1993 by NYC Department of City Planning. The plan states that “greenways would be a system of bicycle-pedestrian pathways along natural and manmade linear spaces such as rail and highway rightsof- way, river corridors, waterfront spaces, parklands and, where necessary, city streets. They are at once the parks for the 21st century and a part of the transportation infrastructure, providing for pleasant, efficient, healthful and environmentally-sound travel by foot, bicycle or skates”. The plan concerns a system of about 570 km of greenways designed to create new opportunities from a recreational point of view, increase the mobility of cyclists and pedestrians and generally speaking was created to enhance the quality of life of NY citizens. The network of greenways brings advantages in many fields, such as citizens health, transportation, socializing development and recreational aspects. As a matter of fact, the plan for NY wants greenways to accomplish different tasks: ⎯ build new spaces that are easily reachable from home and work, through which it is possible to explore and appreciate the different metropolitan environments; ⎯ offer recreational advantages (sunbathing, staying outdoors, admiring the landscape, relax, getting in touch with nature, etc.); ⎯ improve people health (physical activities, outdoor sports); ⎯ provide an alternative, completion and integration with traditional means of transportation; ⎯ provide the possibility to decrease traffic and urban pollution; ⎯ build natural “buffer zones” to separate areas with different functions (residential areas, commercial areas, etc.); ⎯ represent a meeting place to socialize with other people

Soft Mobility Network for the Enhancement and Discovery of the Rural Landscape: Definition of a Masterplan for Alto Ferrarese (Italy)

The rural landscape can provide a wide range of cultural ecosystem services to humans through direct and in situ interactions. The benefits provided depend on the quality of the landscape, but also on the real possibility for people to access and enjoy it. One of the best ways is to do it in a “slow” way, namely active and non-motorized, through a soft mobility network. The goals of the study are: (i) to develop a methodology to plan a soft mobility network that enhances existing infrastructures and maximizes the cultural ecosystem services provided by rural landscapes; (ii) to validate the methodology in the Alto Ferrarese territory through defining a soft mobility masterplan at the supra-municipal scale. The method is made up of three phases: analysis, with the inventory of the resources to be connected and the paths that could potentially be used; assessment, with the evaluation of the suitability of the paths to realize the soft mobility network; and planning, with the definition of the masterplan for the study area. The application resulted in a proposed network of 525.2 km, hierarchized in a primary and a secondary network, and proved that the methodology is effective to maximize the use of existing paths (81% of the proposed network), and to connect the elements of interest (98.5% of the resources are within a distance of 500 m, and 86.4% within a distance of 100 m)

Suburban waterfront with ecological and recreational function: planning based on network analysis

Urban fringe areas have multiple land uses and are places where sections of waterway, together with fragmented areas of natural vegetation, are often found passing through urban areas, transportation routes and gradually expanding rural areas. These overlapping functions are often the cause of an extremely disorderly landscape devoid of guiding connotative elements. In this context, the waterfront can be a guiding element for the redevelopment of the fringe areas between cities and the countryside. The purpose of this paper is the definition of a methodology for planning a suburban waterfront with an ecological function and bicycle paths for recreational use. The evaluation phases for resources and planning, conducted with tools for network analysis, have identified potential corridors based on current land uses and have addressed the issue of bicycle paths on an inter-municipal scale. The methodology is proposed for regional level planning and the validation of the method was achieved through its application to the stretch of the Lambro River between Monza Park and the city of Milan in the North of Italy

Foro y Seminario. El currículum de ciencias naturales de la educación secundaria: retos y desafíos de cara al futuro. Horizontes para la educación científica en Argentina hacia el 2030. Informe Final

Fil: Ferreyra, Horacio Ademar. Universidad Católica de Córdoba. Facultad de Educación; Argentin

Susceptibility to COPD:Differential Proteomic Profiling after Acute Smoking

Cigarette smoking is the main risk factor for COPD (Chronic Obstructive Pulmonary Disease), yet only a subset of smokers develops COPD. Family members of patients with severe early-onset COPD have an increased risk to develop COPD and are therefore defined as "susceptible individuals". Here we perform unbiased analyses of proteomic profiles to assess how "susceptible individuals" differ from age-matched "non-susceptible individuals" in response to cigarette smoking. Epithelial lining fluid (ELF) was collected at baseline and 24 hours after smoking 3 cigarettes in young individuals susceptible or non-susceptible to develop COPD and older subjects with established COPD. Controls at baseline were older healthy smoking and non-smoking individuals. Five samples per group were pooled and analysed by stable isotope labelling (iTRAQ) in duplicate. Six proteins were selected and validated by ELISA or immunohistochemistry. After smoking, 23 proteins increased or decreased in young susceptible individuals, 7 in young non-susceptible individuals, and 13 in COPD in the first experiment; 23 proteins increased or decreased in young susceptible individuals, 32 in young non-susceptible individuals, and 11 in COPD in the second experiment. SerpinB3 and Uteroglobin decreased after acute smoke exposure in young non-susceptible individuals exclusively, whereas Peroxiredoxin I, S100A9, S100A8, ALDH3A1 (Aldehyde dehydrogenase 3A1) decreased both in young susceptible and non-susceptible individuals, changes being significantly different between groups for Uteroglobin with iTRAQ and for Serpin B3 with iTRAQ and ELISA measures. Peroxiredoxin I, SerpinB3 and ALDH3A1 increased in COPD patients after smoking. We conclude that smoking induces a differential protein response in ELF of susceptible and non-susceptible young individuals, which differs from patients with established COPD. This is the first study applying unbiased proteomic profiling to unravel the underlying mechanisms that induce COPD. Our data suggest that SerpinB3 and Uteroglobin could be interesting proteins in understanding the processes leading to COPD

Prolonged diet-induced obesity in mice modifies the inflammatory response and leads to worse outcome after stroke

BACKGROUND: Obesity increases the risk for ischaemic stroke and is associated with worse outcome clinically and experimentally. Most experimental studies have used genetic models of obesity. Here, a more clinically relevant model, diet-induced obesity, was used to study the impact of obesity over time on the outcome and inflammatory response after stroke. METHODS: Male C57BL/6 mice were maintained on a high-fat (60% fat) or control (12% fat) diet for 2, 3, 4 and 6 months when experimental stroke was induced by transient occlusion of the middle cerebral artery (MCAo) for either 20 (6-month diet) or 30 min (2-, 3-, 4- and 6-month diet). Ischaemic damage, blood-brain barrier (BBB) integrity, neutrophil number and chemokine expression in the brain were assessed at 24 h. Plasma chemokine levels (at 4 and 24 h) and neutrophil number in the liver (at 24 h) were measured. Physiological parameters (body weight and blood glucose) were measured in naïve control- and high-fat-fed mice at all time points and blood pressure at 3 and 6 months. Blood cell counts were also assessed in naïve 6-month control- and high-fat-fed mice. RESULTS: Mice fed a high-fat diet for 6 months had greater body weight, blood glucose and white and red blood cell count but no change in systolic blood pressure. After 4 and 6 months of high-fat feeding, and in the latter group with a 30-min (but not 20-min) occlusion of the MCA, obese mice had greater ischaemic brain damage. An increase in blood-brain barrier permeability, chemokine expression (CXCL-1 and CCL3), neutrophil number and microglia/macrophage cells was observed in the brains of 6-month high-fat-fed mice after 30-min MCAo. In response to stroke, chemokine (CXCL-1) expression in the plasma and liver was significantly different in obese mice (6-month high-fat fed), and a greater number of neutrophils were detected in the liver of control but not obese mice. CONCLUSIONS: The detrimental effects of diet-induced obesity on stroke were therefore dependent on the severity of obesity and length of ischaemic challenge. The altered inflammatory response in obese mice may play a key role in its negative impact on stroke

Clinical complexity and impact of the ABC (Atrial fibrillation Better Care) pathway in patients with atrial fibrillation: a report from the ESC-EHRA EURObservational Research Programme in AF General Long-Term Registry

Background: Clinical complexity is increasingly prevalent among patients with atrial fibrillation (AF). The ‘Atrial fibrillation Better Care’ (ABC) pathway approach has been proposed to streamline a more holistic and integrated approach to AF care; however, there are limited data on its usefulness among clinically complex patients. We aim to determine the impact of ABC pathway in a contemporary cohort of clinically complex AF patients. Methods: From the ESC-EHRA EORP-AF General Long-Term Registry, we analysed clinically complex AF patients, defined as the presence of frailty, multimorbidity and/or polypharmacy. A K-medoids cluster analysis was performed to identify different groups of clinical complexity. The impact of an ABC-adherent approach on major outcomes was analysed through Cox-regression analyses and delay of event (DoE) analyses. Results: Among 9966 AF patients included, 8289 (83.1%) were clinically complex. Adherence to the ABC pathway in the clinically complex group reduced the risk of all-cause death (adjusted HR [aHR]: 0.72, 95%CI 0.58–0.91), major adverse cardiovascular events (MACEs; aHR: 0.68, 95%CI 0.52–0.87) and composite outcome (aHR: 0.70, 95%CI: 0.58–0.85). Adherence to the ABC pathway was associated with a significant reduction in the risk of death (aHR: 0.74, 95%CI 0.56–0.98) and composite outcome (aHR: 0.76, 95%CI 0.60–0.96) also in the high-complexity cluster; similar trends were observed for MACEs. In DoE analyses, an ABC-adherent approach resulted in significant gains in event-free survival for all the outcomes investigated in clinically complex patients. Based on absolute risk reduction at 1 year of follow-up, the number needed to treat for ABC pathway adherence was 24 for all-cause death, 31 for MACEs and 20 for the composite outcome. Conclusions: An ABC-adherent approach reduces the risk of major outcomes in clinically complex AF patients. Ensuring adherence to the ABC pathway is essential to improve clinical outcomes among clinically complex AF patients

Impact of renal impairment on atrial fibrillation: ESC-EHRA EORP-AF Long-Term General Registry

Background: Atrial fibrillation (AF) and renal impairment share a bidirectional relationship with important pathophysiological interactions. We evaluated the impact of renal impairment in a contemporary cohort of patients with AF. Methods: We utilised the ESC-EHRA EORP-AF Long-Term General Registry. Outcomes were analysed according to renal function by CKD-EPI equation. The primary endpoint was a composite of thromboembolism, major bleeding, acute coronary syndrome and all-cause death. Secondary endpoints were each of these separately including ischaemic stroke, haemorrhagic event, intracranial haemorrhage, cardiovascular death and hospital admission. Results: A total of 9306 patients were included. The distribution of patients with no, mild, moderate and severe renal impairment at baseline were 16.9%, 49.3%, 30% and 3.8%, respectively. AF patients with impaired renal function were older, more likely to be females, had worse cardiac imaging parameters and multiple comorbidities. Among patients with an indication for anticoagulation, prescription of these agents was reduced in those with severe renal impairment, p <.001. Over 24 months, impaired renal function was associated with significantly greater incidence of the primary composite outcome and all secondary outcomes. Multivariable Cox regression analysis demonstrated an inverse relationship between eGFR and the primary outcome (HR 1.07 [95% CI, 1.01–1.14] per 10 ml/min/1.73 m2 decrease), that was most notable in patients with eGFR <30 ml/min/1.73 m2 (HR 2.21 [95% CI, 1.23–3.99] compared to eGFR ≥90 ml/min/1.73 m2). Conclusion: A significant proportion of patients with AF suffer from concomitant renal impairment which impacts their overall management. Furthermore, renal impairment is an independent predictor of major adverse events including thromboembolism, major bleeding, acute coronary syndrome and all-cause death in patients with AF

Impact of clinical phenotypes on management and outcomes in European atrial fibrillation patients: a report from the ESC-EHRA EURObservational Research Programme in AF (EORP-AF) General Long-Term Registry

Background: Epidemiological studies in atrial fibrillation (AF) illustrate that clinical complexity increase the risk of major adverse outcomes. We aimed to describe European AF patients\u2019 clinical phenotypes and analyse the differential clinical course. Methods: We performed a hierarchical cluster analysis based on Ward\u2019s Method and Squared Euclidean Distance using 22 clinical binary variables, identifying the optimal number of clusters. We investigated differences in clinical management, use of healthcare resources and outcomes in a cohort of European AF patients from a Europe-wide observational registry. Results: A total of 9363 were available for this analysis. We identified three clusters: Cluster 1 (n = 3634; 38.8%) characterized by older patients and prevalent non-cardiac comorbidities; Cluster 2 (n = 2774; 29.6%) characterized by younger patients with low prevalence of comorbidities; Cluster 3 (n = 2955;31.6%) characterized by patients\u2019 prevalent cardiovascular risk factors/comorbidities. Over a mean follow-up of 22.5 months, Cluster 3 had the highest rate of cardiovascular events, all-cause death, and the composite outcome (combining the previous two) compared to Cluster 1 and Cluster 2 (all P <.001). An adjusted Cox regression showed that compared to Cluster 2, Cluster 3 (hazard ratio (HR) 2.87, 95% confidence interval (CI) 2.27\u20133.62; HR 3.42, 95%CI 2.72\u20134.31; HR 2.79, 95%CI 2.32\u20133.35), and Cluster 1 (HR 1.88, 95%CI 1.48\u20132.38; HR 2.50, 95%CI 1.98\u20133.15; HR 2.09, 95%CI 1.74\u20132.51) reported a higher risk for the three outcomes respectively. Conclusions: In European AF patients, three main clusters were identified, differentiated by differential presence of comorbidities. Both non-cardiac and cardiac comorbidities clusters were found to be associated with an increased risk of major adverse outcomes

Large expert-curated database for benchmarking document similarity detection in biomedical literature search

Document recommendation systems for locating relevant literature have mostly relied on methods developed a decade ago. This is largely due to the lack of a large offline gold-standard benchmark of relevant documents that cover a variety of research fields such that newly developed literature search techniques can be compared, improved and translated into practice. To overcome this bottleneck, we have established the RElevant LIterature SearcH consortium consisting of more than 1500 scientists from 84 countries, who have collectively annotated the relevance of over 180 000 PubMed-listed articles with regard to their respective seed (input) article/s. The majority of annotations were contributed by highly experienced, original authors of the seed articles. The collected data cover 76% of all unique PubMed Medical Subject Headings descriptors. No systematic biases were observed across different experience levels, research fields or time spent on annotations. More importantly, annotations of the same document pairs contributed by different scientists were highly concordant. We further show that the three representative baseline methods used to generate recommended articles for evaluation (Okapi Best Matching 25, Term Frequency-Inverse Document Frequency and PubMed Related Articles) had similar overall performances. Additionally, we found that these methods each tend to produce distinct collections of recommended articles, suggesting that a hybrid method may be required to completely capture all relevant articles. The established database server located at https://relishdb.ict.griffith.edu.au is freely available for the downloading of annotation data and the blind testing of new methods. We expect that this benchmark will be useful for stimulating the development of new powerful techniques for title and title/abstract-based search engines for relevant articles in biomedical research.Peer reviewe