Zr-metal adhesion on graphenic nanostructures

3 pages, 3 figures.-- PACS nrs.: 68.35.Np, 61.46.Fg, 61.46.Df.Our high resolution transmission electronic microscopy studies of multiwall carbon nanotubes show, after the growth of zirconia nanoparticles by a hydrothermal route, the presence of surface Zr, forming an atomically thin layer. Using first-principles calculations we investigate the nature of the Zr–C interaction, which is neither ionic nor covalent, and the optimal coverage for the Zr metal in a graphene flake. This preferred coverage is in agreement with that deduced from electron energy loss spectra experiments. We show also that the amount of charge transferred to the C layer saturates as the Zr coverage increases and the Zr–C bond becomes weaker.We want to acknowledge the support by the ETORTEK (NANOMAT) program of the Basque government, the Intramural Special Project (Reference No. 2006601242), the Spanish Ministerio de Ciencia y Tecnología (MCyT) of Spain (Grant No. Fis 2007-66711-C02-C01), and the European Network of Excellence NANOQUANTA (NM4-CT-2004-500198). Y.S.P. gratefully acknowledges his DIPC grant.Peer reviewe

X-rays and hard UV radiation From the First Galaxies: Ionization Bubbles and 21 cm Observations

The first stars and quasars are known sources of hard ionizing radiation in the first billion years of the Universe. We examine the joint effects of X-rays and hard UV radiation from such first-light sources on the hydrogen and helium reionization of the intergalactic medium (IGM) at early times, and the associated heating. We study the growth and evolution of individual HII, HeII and HeIII regions around early galaxies with first stars and/or QSO populations. We find that in the presence of helium-ionizing radiation, X-rays may not dominate the ionization and thermal history of the IGM at redshifts, z, of 10-20, contributing relatively modest increases to IGM ionization, and heating up to about 10^3--10^5 K in IGM temperatures. We also calculate the 21 cm signal expected from a number of scenarios with metal-free starbursts and quasars at these redshifts. The peak values for the spin temperature reach about 10^4 to 10^5 K in such cases. The maximum values for the 21 cm brightness temperature are around 30-40 mK in emission, while the net values of the 21 cm absorption signal range from about a few to 60 mK on scales of 0.01-1 Mpc. We find that the 21 cm signature of X-ray versus UV ionization could be distinct, with the emission signal expected from X-rays alone occurring at smaller scales than that from UV radiation, resulting from the inherently different spatial scales at which X-ray and UV ionization/heating manifest. This difference is time-dependent, and becomes harder to distinguish with an increasing X-ray contribution to the total ionizing photon production. Such differing scale-dependent contributions from X-ray and UV photons may therefore "blur" the 21 cm signature of the percolation of ionized bubbles around early halos (depending on whether a cosmic X-ray or UV background built up first), and affect the interpretation of 21 cm data constraints on reionization.Comment: Accepted for publication in MNRAS; 15 pages, 14 figure

Blockade of T-cell activation by dithiocarbamates involves novel mechanisms of inhibition of nuclear factor of activated T cells.

Dithiocarbamates (DTCs) have recently been reported as powerful inhibitors of NF-kappaB activation in a number of cell types. Given the role of this transcription factor in the regulation of gene expression in the inflammatory response, NF-kappaB inhibitors have been suggested as potential therapeutic drugs for inflammatory diseases. We show here that DTCs inhibited both interleukin 2 (IL-2) synthesis and membrane expression of antigens which are induced during T-cell activation. This inhibition, which occurred with a parallel activation of c-Jun transactivating functions and expression, was reflected by transfection experiments at the IL-2 promoter level, and involved not only the inhibition of NF-kappaB-driven reporter activation but also that of nuclear factor of activated T cells (NFAT). Accordingly, electrophoretic mobility shift assays (EMSAs) indicated that pyrrolidine DTC (PDTC) prevented NF-kappaB, and NFAT DNA-binding activity in T cells stimulated with either phorbol myristate acetate plus ionophore or antibodies against the CD3-T-cell receptor complex and simultaneously activated the binding of AP-1. Furthermore, PDTC differentially targeted both NFATp and NFATc family members, inhibiting the transactivation functions of NFATp and mRNA induction of NFATc. Strikingly, Western blotting and immunocytochemical experiments indicated that PDTC promoted a transient and rapid shuttling of NFATp and NFATc, leading to their accelerated export from the nucleus of activated T cells. We propose that the activation of an NFAT kinase by PDTC could be responsible for the rapid shuttling of the NFAT, therefore transiently converting the sustained transactivation of this transcription factor that occurs during lymphocyte activation, and show that c-Jun NH2-terminal kinase (JNK) can act by directly phosphorylating NFATp. In addition, the combined inhibitory effects on NFAT and NF-KB support a potential use of DTCs as immunosuppressants

Nature of the spin-glass phase at experimental length scales

We present a massive equilibrium simulation of the three-dimensional Ising spin glass at low temperatures. The Janus special-purpose computer has allowed us to equilibrate, using parallel tempering, L=32 lattices down to T=0.64 Tc. We demonstrate the relevance of equilibrium finite-size simulations to understand experimental non-equilibrium spin glasses in the thermodynamical limit by establishing a time-length dictionary. We conclude that non-equilibrium experiments performed on a time scale of one hour can be matched with equilibrium results on L=110 lattices. A detailed investigation of the probability distribution functions of the spin and link overlap, as well as of their correlation functions, shows that Replica Symmetry Breaking is the appropriate theoretical framework for the physically relevant length scales. Besides, we improve over existing methodologies to ensure equilibration in parallel tempering simulations.Comment: 48 pages, 19 postscript figures, 9 tables. Version accepted for publication in the Journal of Statistical Mechanic

Measurements of the Electron-Helicity Dependent Cross Sections of Deeply Virtual Compton Scattering with CEBAF at 12 GeV

We propose precision measurements of the helicity-dependent and helicity independent cross sections for the ep->epg reaction in Deeply Virtual Compton Scattering (DVCS) kinematics. DVCS scaling is obtained in the limits Q^2>>Lambda_{QCD}^2, x_Bj fixed, and -\Delta^2=-(q-q')^22 GeV^2, W>2 GeV, and -\Delta^21 GeV^2. We will use our successful technique from the 5.75 GeV Hall A DVCS experiment (E00-110). With polarized 6.6, 8.8, and 11 GeV beams incident on the liquid hydrogen target, we will detect the scattered electron in the Hall A HRS-L spectrometer (maximum central momentum 4.3 GeV/c) and the emitted photon in a slightly expanded PbF_2 calorimeter. In general, we will not detect the recoil proton. The H(e,e'g)X missing mass resolution is sufficient to isolate the exclusive channel with 3% systematic precision

El liderazgo y la cultura organizacional en la Institución Educativa No. 5088 "Héroes del Pacífico" Ventanilla- Callao - 2013

La investigación tuvo por objetivo principal establecer la relación del liderazgo y la cultura organizacional de la Institución Educativa Nº 5088 Héroes del Pacífico – Ventanilla – Callao – 2012, y responde al problema general ¿Cuál es la relación existente entre el liderazgo y la cultura organizacional en la Institución Educativa Nº 5088 Héroes del Pacífico – Ventanilla – Callao – 2012?. Bajo un enfoque no experimental, ciñéndose al diseño descriptivo correlacional, para esta investigación se consideró como muestra a todo el personal docente y administrativo, que asciende a 56 personas (50 docentes y 6 administrativos) y se les aplicó un cuestionario de 109 ítems elaborado para el presente estudio, procesándose los datos recogidos con el paquete estadístico SPSS (Stadistic Package Sciencie Social = Paquete Estadístico para Ciencias Sociales). Los resultados del análisis estadístico dan cuenta de la existencia de una relación r = 0,875 entre la variables: liderazgo y cultura organizacional. Este grado de correlación indica que la relación entre las variables es positiva y con un nivel de correlación muy alta. La significancia de p=0,000 muestra que p es menor a 0,05, entonces el liderazgo tiene relación positiva y significativa con la cultura organizacional en la Institución Educativa Nº 5088 Héroes del Pacífico – Ventanilla – Callao – 201

Efficacy of capacitive resistive monopolar radiofrequency in the physiotherapeutic treatment of chronic pelvic pain syndrome : study protocol for a randomized controlled trial

Chronic pelvic pain syndrome (CPPS) is a multifactorial disorder that affects 5.7% to 26.6% of women and 2.2% to 9.7% of men, characterized by hypersensitivity of the central and peripheral nervous system affecting bladder and genital function. People with CPPS have much higher rates of psychological disorders (anxiety, depression, and catastrophizing) that increase the severity of chronic pain and worsen quality of life. Myofascial therapy, manual therapy, and treatment of trigger points are proven therapeutic options for this syndrome. This study aims to evaluate the efficacy of capacitive resistive monopolar radiofrequency (CRMRF) at 448kHz as an adjunct treatment to other physiotherapeutic techniques for reducing pain and improving the quality of life of patients with CPPS. This triple-blind (1:1) randomized controlled trial will include 80 women and men with CPPS. Participants will be randomized into a CRMRF activated group or a CRMRF deactivated group and receive physiotherapeutic techniques and pain education. The groups will undergo treatment for 10 consecutive weeks. At the beginning of the trial there will be an evaluation of pain intensity (using VAS), quality of life (using the SF-12), kinesiophobia (using the TSK-11), and catastrophism (using the PCS), as well as at the sixth and tenth sessions. The results of this study will show that CRMRF benefits the treatment of patients with CPPS, together with physiotherapeutic techniques and pain education. These results could offer an alternative conservative treatment option for these patients. ClinicalTrials.gov . Registered on 8 January 2019. The online version contains supplementary material available at 10.1186/s13063-021-05321-6

Multi-messenger observations of a binary neutron star merger

On 2017 August 17 a binary neutron star coalescence candidate (later designated GW170817) with merger time 12:41:04 UTC was observed through gravitational waves by the Advanced LIGO and Advanced Virgo detectors. The Fermi Gamma-ray Burst Monitor independently detected a gamma-ray burst (GRB 170817A) with a time delay of ~1.7 s with respect to the merger time. From the gravitational-wave signal, the source was initially localized to a sky region of 31 deg2 at a luminosity distance of 40+8-8 Mpc and with component masses consistent with neutron stars. The component masses were later measured to be in the range 0.86 to 2.26 Mo. An extensive observing campaign was launched across the electromagnetic spectrum leading to the discovery of a bright optical transient (SSS17a, now with the IAU identification of AT 2017gfo) in NGC 4993 (at ~40 Mpc) less than 11 hours after the merger by the One- Meter, Two Hemisphere (1M2H) team using the 1 m Swope Telescope. The optical transient was independently detected by multiple teams within an hour. Subsequent observations targeted the object and its environment. Early ultraviolet observations revealed a blue transient that faded within 48 hours. Optical and infrared observations showed a redward evolution over ~10 days. Following early non-detections, X-ray and radio emission were discovered at the transient’s position ~9 and ~16 days, respectively, after the merger. Both the X-ray and radio emission likely arise from a physical process that is distinct from the one that generates the UV/optical/near-infrared emission. No ultra-high-energy gamma-rays and no neutrino candidates consistent with the source were found in follow-up searches. These observations support the hypothesis that GW170817 was produced by the merger of two neutron stars in NGC4993 followed by a short gamma-ray burst (GRB 170817A) and a kilonova/macronova powered by the radioactive decay of r-process nuclei synthesized in the ejecta

Self-Propelled Multifunctional Microrobots Harboring Chiral Supramolecular Selectors for "Enantiorecogniton-on-the-Fly"

Herein, a general procedure for the synthesis of multifunctional MRs, which simultaneously exhibit i) chiral, ii) magnetic, and iii) fluorescent properties in combination with iv) self-propulsion, is reported. Self-propelled Ni@Pt superparamagnetic microrockets have been functionalized with fluorescent CdS quantum dots carrying a chiral host biomolecule as beta-cyclodextrin (beta-CD). The "on-the-fly" chiral recognition potential of MRs has been interrogated by taking advantage of the beta-CD affinity to supramolecularly accommodate different chiral biomolecules (i.e., amino acids). As a proof-of-concept, tryptophan enantiomers have been discriminated with a dual-mode (optical and electrochemical) readout. This approach paves the way to devise intelligent cargo micromachines with "built-in" chiral supramolecular recognition capabilities to elucidate the concept of "enantiorecognition-on-the-fly", which might be facilely customized by tailoring the supramolecular host-guest encapsulation