6 research outputs found
Bace2 Is a Beta-Cell-Enriched Protease that Regulates Pancreatic Beta-Cell Function and Mass
- Author
- Publication venue
- Cell Press
- Publication date
- 01/01/2011
- Field of study
Decreased ? cell mass and function are hallmarks of type 2 diabetes. Here we identified, through a siRNA screen, beta site amyloid precursor protein cleaving enzyme 2 (Bace2) as the sheddase of the proproliferative plasma membrane protein Tmem27 in murine and human ? cells. Mice with functionally inactive Bace2 and insulin-resistant mice treated with a newly identified Bace2 inhibitor both display augmented ? cell mass and improved control of glucose homeostasis due to increased insulin levels. These results implicate Bace2 in the control of ? cell maintenance and provide a rational strategy to inhibit this protease for the expansion of functional pancreatic ? cell mass
The Biochemical Machinery of Plastid Envelope Membranes
- Author
- Adessi
- Avelange-Macherel
- Barbier-Brygoo
- Blée
- Browsher
- Douce
- Dörmann
- Fischer
- Flügge
- Heiber
- Heins
- Heinz
- Jäger-Vottero
- Kammerer
- Koornneef
- Kropat
- Lichtenthaler
- Lichtenthaler
- Maréchal
- Marin
- Marisson
- Matile
- Matringe
- Mi
- Miquel
- Nakayama
- Pineau
- Pohlmeyer
- Reinbothe
- Rolland
- Rossak
- Sandman
- Sato
- Sato
- Sato
- Schmidt
- Shimojima
- Swiezewska
- Vick
- Zerges
- Publication venue
- 'American Society of Plant Biologists (ASPB)'
- Publication date
- Field of study
Diagramm, Illustration, Imagination.
- Author
- Authier Michel
- Dürer Albrecht
- Goethe Brief
- Gombrich Ernst H.
- Gombrich Siehe Ernst H.
- Herder Johann Gottfried
- Hofmann Werner
- Hofmann Werner
- Ludwig Tieck Brief
- Ludwig Tieck Brief
- Ludwig Tieck Brief
- Ludwig Tieck Siehe
- Matile Heinz
- Mörzer-Bruyns W. P. J.
- Vgl HS I S.
- zur Schiffergesellschaft Karl Friedrich Siehe
- ätzliche Die
- Publication venue
- 'Vandenhoeck & Ruprecht GmbH & Co, KG'
- Publication date
- Field of study
Bace2 is a β cell-enriched protease that regulates pancreatic β cell function and mass
- Author
- Akpinar
- Alexander Schmidt
- Altirriba
- Bennett
- Bernhard Boehm
- Bettegazzi
- Cavallaro
- Cristiano Migliorini
- Danilczyk
- Daria Esterházy
- Domenico Bosco
- Dominguez
- Donath
- Efrat
- Farzan
- Finzi
- Fluhrer
- Francis
- Fukui
- Gandhi
- Giatgen Andreia Spinas
- Gruninger-Leitch
- Haiyan Wang
- Han
- Hans Hilpert
- Heinz Döbeli
- Hemming
- Holger Moch
- Hugues Matile
- Hussain
- Hussain
- Ina Stützer
- Jeremy Beauchamp
- Julie Kerr-Conte
- Kahn
- Kim
- Kuhn
- Lorella Marselli
- Maechler
- Malakauskas
- Malakauskas
- Markus Stoffel
- Markus P. Rechsteiner
- Michael Prummer
- Nora Lieske
- Park
- Parnaud
- Roe
- Ruedi Aebersold
- Shih
- Sun
- Turner
- Turner
- Walter
- Winzell
- Wollscheid
- Yan
- Zhang
- Zhang
- Zhao
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2011
- Field of study
Decreased β cell mass and function are hallmarks of type 2 diabetes. Here we identified, through a siRNA screen, beta site amyloid precursor protein cleaving enzyme 2 (Bace2) as the sheddase of the proproliferative plasma membrane protein Tmem27 in murine and human β cells. Mice with functionally inactive Bace2 and insulin-resistant mice treated with a newly identified Bace2 inhibitor both display augmented β cell mass and improved control of glucose homeostasis due to increased insulin levels. These results implicate Bace2 in the control of β cell maintenance and provide a rational strategy to inhibit this protease for the expansion of functional pancreatic β cell mass
Fungal Lipids
- Author
- Abe
- Accoceberry
- Adam
- Adams
- Agarwall
- Agranoff
- Altman
- Amdur
- Anderson
- Ando
- Audette
- Baker
- Ballance
- Bandlow
- Baraud
- Baraud
- Baraud
- Barron
- Bartnicki-Garcia
- Barton
- Barton
- Barton
- Barton
- Barton
- Barton
- Bean
- Bednarz-Prashad
- Beereboom
- Bennett
- Bentley
- Bergel'son
- Bharusha
- Bharusha
- Bianchi
- Blank
- Bloch
- Bloch
- Bloomfield
- Boulton
- Bowman
- Brady
- Braun
- Braun
- Breivik
- Brett
- Brodie
- Brown
- Brushaber
- Bu'lock
- Caldwell
- Cantrell
- Carter
- Castelli
- Chappell
- Chattaway
- Chen
- Chesters
- Chisholm
- Clarke
- Clayton
- Clenshaw
- Cobon
- Collier
- Collins
- Combs
- Coots
- Cornforth
- Davidoff
- Dean
- Dedyukhina
- Deierkauf
- DiMari
- Divakaran
- Domer
- Dubé
- Elinor
- Ellenbogen
- Enebo
- Enebo
- Epstein
- Epstein
- Erwin
- Erwin
- Fabre-Joneau
- Folkers
- Foppen
- Fryberg
- Fryberg
- Fulco
- Fulco
- Gad
- Gaylor
- Getz
- Gorin
- Gottlieb
- Goulston
- Goulston
- Graff
- Green
- Gribanovski-Sassu
- Gribanovski-Sassu
- Griddle
- Griffin
- Guider
- Gunasekaran
- Gunasekaran
- Gunasekaran
- Gunasekaran
- Gunasekaran
- Gurr
- Gurr
- Hall
- Hall
- Halsall
- Hanahan
- Handa
- Hardesty
- Harlan
- Hartman
- Hartman
- Hartman
- Haskell
- Haskins
- Haskins
- Haskins
- Hatanaka
- Hay
- Hebert
- Heinz
- Hitchcock
- Hofmann
- Holley
- Holtz
- Holtz
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- Howell
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- Hughes
- Hunter
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- James
- Johnston
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- Karlsson
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- Mercer
- Merdinger
- Merdinger
- Merdinger
- Merdinger
- Meyer
- Meyer
- Milazzo
- Mills
- Mizuno
- Molitoris
- Moore
- Morell
- Morell
- Morris
- Morris
- Morris
- Mudd
- Mudd
- Mulheirn
- Mumma
- Mumma
- Nakajima
- Naquib
- Nielsen
- Nowak
- Nugleren
- Nurminen
- Nurminen
- O'Leary
- Ongun
- Orme
- Oro
- Osman
- Paltauf
- Paltauf
- Pan
- Pan
- Peck
- Popjak
- Popjak
- Powell
- Prottey
- Pugh
- Pugh
- Qureshi
- Rambo
- Rattray
- Rilling
- Ripple
- Rogers
- Roncari
- Rossiter
- Rozijn
- Ruinen
- Safe
- Salmonowitz
- Schatz
- Schibeci
- Schibeci
- Schiller
- Schroepfer
- Schultz
- Schweizer
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- Shafai
- Shah
- Sharratt
- Shaw
- Shaw
- Shaw
- Shaw
- Shechter
- Shechter
- Shimi
- Singh
- Singh
- Singh
- Singh
- Snell
- Sprechter
- Stanacev
- Stanacev
- Starkey
- Steinberg
- Steiner
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- Stodola
- Stodola
- Stoffel
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- Stone
- Stoops
- Strigina
- Sumner
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- Sumner
- Sumper
- Suomalainen
- Suomalainen
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- Suomalainen
- Sweeley
- Sweeley
- Talamo
- Talbot
- Tanahashi
- Thiele
- Thompson
- Todd
- Trevelyan
- Trione
- Trocha
- Tulloch
- Tulloch
- Tulloch
- Turner
- Tyrrell
- Tyrrell
- Tyrrell
- Vacheron
- Vagelos
- Vagelos
- Van der Wilden
- Van Etten
- Vaver
- Vesonder
- Vignais
- Waechter
- Wagner
- Wagner
- Wagner
- Wakil
- Wakil
- Wakil
- Walker
- Wassef
- Wassef
- Weete
- Weete
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- Weete
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- Weiss
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- Wieland
- Willecke
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- Woodbine
- Wykle
- Yang
- Yokokawa
- Yokokawa
- Yuan
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/1977
- Field of study
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- Sarojini
- Sato
- Satre
- Sawhney
- Sawhney
- Schaefer
- Schardl
- Schatz
- Schell
- Schindler
- Schirch
- Schleyer
- Schmitt
- Schnaitman
- Schnaitman
- Schnare
- Schnarrenberger
- Schneider
- Schonbaum
- Schwertner
- Schwitzguebel
- Sells
- Sha'afi
- Shimomura
- Siedow
- Siedow
- Siedow
- Siess
- Silva-Lima
- Silva-Lima
- Simcox
- Sinclair
- Singer
- Singer
- Singer
- Singer
- Singh
- Sitaramam
- Sjöstrand
- Sjöstrand
- Slater
- Sluse
- Smith
- Smith
- Smyth
- Smyth
- Smyth
- Solomos
- Solomos
- Soloway
- Sottocasa
- Spahr
- Spalding
- Sparace
- Sparace
- Sparks
- Spencer
- Sperk
- Srere
- Staehelin
- Stenlid
- Stern
- Stern
- Stewart
- Stewart
- Stewart
- Stitt
- Stitt
- Stitt
- Stitt
- Stitt
- Stitt
- Stitt
- Stitt
- Stitt
- Stoner
- Storey
- Storey
- Storey
- Storey
- Storey
- Storey
- Storey
- Storey
- Storey
- Storey
- Storey
- Stubbs
- Stubbs
- Stumpf
- Sumida
- Sumida
- Suyama
- Swamy
- Swift
- Swift
- Szaniawski
- Szarkowska
- Tager
- Takeda
- Tanner
- Tassi
- Terada
- Tetley
- Tezuka
- Thebud
- Theologis
- Thimann
- Thomas
- Thomas
- Thompson
- Ting
- Ting
- Ting
- Tischler
- Tobin
- Tolbert
- Tolbert
- Tolbert
- Tomomatsu
- Tourte
- Trumpower
- Trumpower
- Tuppy
- Turner
- Tzagoloff
- Tzagoloff
- Usuda
- Uzzell
- Valenti
- Van Schaftingen
- Van Sumere
- Vanderleyden
- Vartapetian
- Vartapetian
- Vartapetian
- Vasconcelos
- Vedel
- Verhaeren
- Vignais
- Vignais
- Vignais
- Vignais
- Von Jagow
- Von Jagow
- Wagner
- Waidyanatha
- Wainio
- Walker
- Walker
- Walker
- Wallsgrove
- Wallsgrove
- Walsh
- Ward
- Waterton
- Wattiaux-De Coninck
- Weil
- Weinbach
- Wells
- Whatley
- Whatley
- Wickner
- Widger
- Wikström
- Wikström
- Wikström
- Wildman
- Wildman
- Williams
- Williams
- Williamson
- Williamson
- Wilson
- Wilson
- Wilson
- Wilson
- Wilson
- Wilson
- Wilson
- Wingfield
- Wirtz
- Wirtz
- Wiskich
- Wiskich
- Wiskich
- Wiskich
- Wiskich
- Wiskich
- Wittenbach
- Woese
- Wohlrab
- Wojtczak
- Wojtczak
- Wojtczak
- Woo
- Woo
- Woo
- Woo
- Wrigglesworth
- Wu
- Yonetani
- Yoshida
- Yoshida
- Yu
- Yu
- Yu
- Yu
- Zalman
- Zimmermann
- Zimmermann
- Zoratti
- Zwizinski
- Zwizinski
- Åkerman
- Åkerman
- Öpik
- Öpik
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/1985
- Field of study