763 research outputs found
The Chinese medicine formula HB01 reduces choroidal neovascularization by regulating the expression of vascular endothelial growth factor
- Author
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Single-cell resolution imaging of retinal ganglion cell apoptosis in vivo using a cell-penetrating caspase-activatable peptide probe
- Author
- B Oakley 2nd
- BA Berkowitz
- Bradley S. Wilson
- CA Schneider
- CJ Jeon
- D Maxwell
- David Piwnica-Worms
- DJ Calkins
- E Schellenberger
- Edward M. Barnett
- EM Barnett
- EM Barnett
- G Kemerink
- HA Quigley
- I Vermes
- IH Pang
- J Schoenberger
- James R. Johnson
- JC Reed
- JR Johnson
- JT Opferman
- K Bullok
- K Zhang
- KE Bullok
- KE Bullok
- KE Bullok
- Kin-Sang Cho
- M Brauer
- M Cordeiro
- M Cordeiro
- M Roh
- MF Cordeiro
- MI van der Reis
- P Villa
- QT Nguyen
- R Weissleder
- RF Miller
- S Gross
- Seth T. Gammon
- VA Fadok
- Xudong Qiu
- Publication venue
- Digital Commons@Becker
- Publication date
- 01/01/2014
- Field of study
Peptide probes for imaging retinal ganglion cell (RGC) apoptosis consist of a cell-penetrating peptide targeting moiety and a fluorophore-quencher pair flanking an effector caspase consensus sequence. Using ex vivo fluorescence imaging, we previously validated the capacity of these probes to identify apoptotic RGCs in cell culture and in an in vivo rat model of N-methyl- D-aspartate (NMDA)-induced neurotoxicity. Herein, using TcapQ488, a new probe designed and synthesized for compatibility with clinically-relevant imaging instruments, and real time imaging of a live rat RGC degeneration model, we fully characterized time- and dose-dependent probe activation, signal-to-noise ratios, and probe safety profiles in vivo. Adult rats received intravitreal injections of four NMDA concentrations followed by varying TcapQ488 doses. Fluorescence fundus imaging was performed sequentially in vivo using a confocal scanning laser ophthalmoscope and individual RGCs displaying activated probe were counted and analyzed. Rats also underwent electroretinography following intravitreal injection of probe. In vivo fluorescence fundus imaging revealed distinct single-cell probe activation as an indicator of RGC apoptosis induced by intravitreal NMDA injection that corresponded to the identical cells observed in retinal flat mounts of the same eye. Peak activation of probe in vivo was detected 12 hours post probe injection. Detectable fluorescent RGCs increased with increasing NMDA concentration; sensitivity of detection generally increased with increasing TcapQ488 dose until saturating at 0.387 nmol. Electroretinography following intravitreal injections of TcapQ488 showed no significant difference compared with control injections. We optimized the signal-to-noise ratio of a caspase-activatable cell penetrating peptide probe for quantitative non-invasive detection of RGC apoptosis in vivo. Full characterization of probe performance in this setting creates an important in vivo imaging standard for functional evaluation of future probe analogues and provides a basis for extending this strategy into glaucoma-specific animal models
A systematic review of outcome and outcome-measure reporting in randomised trials evaluating surgical interventions for anterior-compartment vaginal prolapse: a call to action to develop a core outcome set
- Author
- A Khalil
- A McNanley
- A Qatawneh FA-K
- A Vollebregt
- A Vollebregt
- AA Sivaslioglu
- Abdullatif Elfituri
- AC Ballard
- AH MacLennan
- AL Milani
- AM Weber
- Annemarie Van Der Steen
- Bindiya Gupta
- C Glazener
- C Maher
- CA Delroy
- CB Iglesia
- CC Huang
- CM Durnea
- CM Glazener
- Constantin M. Durnea
- D Altman
- DD Antosh
- DG Tincello
- E Borstad
- E Costantini
- E Dahlgren
- E Stekkinger
- EJ Geller
- EW Henn
- F Natale
- G Kamilya
- G Lamblin
- G Lose
- G Quadri NN
- G Thiagamoorthy
- HK Park
- I Khalil
- J 't Hooft van
- J Duffy
- J Duffy
- J Farthmann
- J Webbe
- James M. N. Duffy
- JL Segal
- JM Choe
- JM Duffy
- JM Ploeg van der
- JMN Duffy
- JMN Duffy
- JMN Duffy
- JMN Duffy
- John T. Wei
- JS Yuk
- JT Benson
- JT Tamanini
- JT Tamanini
- JT Tamanini
- K Glavind
- K Nieminen
- K Nieminen
- KC Whitehouse
- L Schierlitz
- Lauren B. Westermann
- Lauren Chmielewski
- Lina Bergstrom
- M Carey
- M Colombo
- M Ek
- M Ek
- M Hirsch
- M Meschia
- M Robert
- M Rudnicki
- M Rudnicki
- M Turgal
- M Weemhoff
- MA El-Nazer
- MI Withagen
- MI Withagen
- MM Dias
- NK Anderson
- NL Guerette
- NL Harman
- P Madhuvrata
- PC Feldner Jr
- PC Feldner Jr
- PK Sand
- R Bray
- R Hiltunen
- R Tayrac de
- RA Hakvoort
- RN Pauls
- S Da Silveira Dos Reis Brandao
- S Gandhi
- SA Menefee
- SL Hendrix
- Stergios K. Doumouchtsis
- T Tantanasis
- U Hviid
- U Kringel
- V Miranda
- VA Minassian
- Vasilios Pergialiotis
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2018
- Field of study
INTRODUCTION: We assessed outcome and outcome-measure reporting in randomised controlled trials evaluating surgical interventions for anterior-compartment vaginal prolapse and explored the relationships between outcome reporting quality with journal impact factor, year of publication, and methodological quality. METHODS: We searched the bibliographical databases from inception to October 2017. Two researchers independently selected studies and assessed study characteristics, methodological quality (Jadad criteria; range 1-5), and outcome reporting quality Management of Otitis Media with Effusion in Cleft Palate (MOMENT) criteria; range 1-6], and extracted relevant data. We used a multivariate linear regression to assess associations between outcome reporting quality and other variables. RESULTS: Eighty publications reporting data from 10,924 participants were included. Seventeen different surgical interventions were evaluated. One hundred different outcomes and 112 outcome measures were reported. Outcomes were inconsistently reported across trials; for example, 43 trials reported anatomical treatment success rates (12 outcome measures), 25 trials reported quality of life (15 outcome measures) and eight trials reported postoperative pain (seven outcome measures). Multivariate linear regression demonstrated a relationship between outcome reporting quality with methodological quality (ÎČâ=â0.412; Pâ=â0.018). No relationship was demonstrated between outcome reporting quality with impact factor (ÎČâ=â0.078; Pâ=â0.306), year of publication (ÎČâ=â0.149; Pâ=â0.295), study size (ÎČâ=â0.008; Pâ=â0.961) and commercial funding (ÎČâ=â-0.013; Pâ=â0.918). CONCLUSIONS: Anterior-compartment vaginal prolapse trials report many different outcomes and outcome measures and often neglect to report important safety outcomes. Developing, disseminating and implementing a core outcome set will help address these issues
Bone turnover markers in sheep and goat: a review of the scientific literature
- Author
- ALLEN MJ
- ALLEN MJ.
- ALTMAN AR
- ANDERSON ML
- ANDREASEN CM
- ARENS D
- BAHARUDDIN NA
- CAMILA C. DIOGO
- CARLOS A. VIEGAS
- CEPELAK I
- CHANETSA F
- CHAVASSIEUX P
- CHAVASSIEUX P
- CHAVASSIEUX P
- CHUBB SA.
- CLARKE B.
- COLLIGNON H
- COULIBALY MO
- CREMERS S
- CRISTINA P. SOUSA
- DELMAS PD
- DIAS IR
- DING M
- GERRITS MI
- GOEBEL S
- HADJIDAKIS DJ
- HANNON RA
- HINTERMEISTER JG
- IGLESIAS L
- ISABEL R. DIAS
- JOHNSON RB
- JORGE T. AZEVEDO
- JOSĂ A. CAMASSA
- KIEĆBOWICZ Z
- KIEĆBOWICZ Z
- KLEIN P
- KREIPKE TC
- LEEMING DJ
- LIEBSCHNER MA.
- LIESEGANG A
- LIESEGANG A
- LIESEGANG A
- LIESEGANG A
- LIESEGANG A
- LIESEGANG A.
- LILL CA
- LILL CA
- LOMEO A
- MACLEAY JM
- MACLEAY JM
- MASROUR RJ
- MILLAN JL.
- MOGHADDAM A
- NAFEI A
- NEVE A
- NEWMAN E
- NEWTON BI
- NICODEMO ML
- NUNO DOURADO
- O'LOUGHLIN PF
- PASKALEV M
- PASTOUREAU P
- PEARCE AI
- PRICE JS
- RAGGATT LJ
- RAVAGLIOLI A
- REICHERT JC
- REINWALD S
- RUI L. REIS
- SCHMIDT J
- SCHMIT JM
- SCOTT D
- SEEBECK P
- SEEMAN E.
- SEIBEL MJ
- SEIBEL MJ
- SEIBEL MJ.
- SEIBEL MJ.
- SEIBEL MJ.
- SIGRIST IM
- SMITH SY
- SOUBERBIELLE JC
- SOUSA C
- SOUSA CP
- SOUSA CP
- SOUSA CP
- TATARA MR.
- TAYLOR MS
- TRALMAN G
- TURNER AS
- TURNER AS
- TURNER AS
- TURNER AS
- VAN DER DONK S
- VASIKARAN S
- VERNON KL
- WAN ZAHARI M
- WATTS NB.
- WHEATER G
- WHYTE MP.
- WILKENS MR
- WINDHAGEN H
- Publication venue
- 'FapUNIFESP (SciELO)'
- Publication date
- 01/01/2017
- Field of study
Bone turnover markers (BTMs) are product of bone cell activity and are generally divided in bone formation and bone resorption markers. The purpose of this review was to structure the available information on the use of BTMs in studies on small ruminants, especially for monitoring their variations related to diet, exercise, gestation and metabolic lactation state, circadian and seasonal variations, and also during skeletal growth. Pre-clinical and translational studies using BTMs with sheep and goats as animal models in orthopaedic research studies to help in the evaluation of the fracture healing process and osteoporosis research are also described in this review. The available information from the reviewed studies was systematically organized in order to highlight the most promising BTMs in small ruminant research, as well as provide a wide view of the use of sheep and goat as animal models in orthopaedic research, type of markers and commercial assay kits with cross-reactivity in sheep and goat, method of sample and storage of serum and urine for bone turnover markers determination and the usefulness and limitations of bone turnover markers in the different studies, therefore an effective tool for researchers that seek answers to different questions while using BTMs in small ruminants.José Arthur de A. Camassa acknowledges to the
Conselho Nacional de Desenvolvimento CientĂfico
e TecnolĂłgico (CNPq), Brazil, for his PhD
scholarship 202248/2015-1.info:eu-repo/semantics/publishedVersio
Production of drinking water using a multi-barrier approach integrating nanofiltration: A pilot scale study
- Author
- Al-Amoudi
- Alexandre Rodrigues
- Ana I. Penetra
- Benitez
- Canonica
- Cristina T. Matos
- Cyna
- Dubois
- Elisabete Ferreira
- Gozzi
- Guo
- Haque
- Her
- Huber
- JoĂŁo G. Crespo
- Kluplel
- KlĂŒpfel
- Koyuncu
- Linden
- Lowry
- LuĂs B. Bucha
- Madaeni
- Mafalda Pessoa Lopes
- Marconnet
- Maria A.M. Reis
- Maria Ermelinda Valério
- Maria JoĂŁo Benoliel
- McCallum
- Mi
- Mosqueda-Jiminez
- Oliveira
- Peiris
- Peldszus
- Pereira
- Qaisrani
- Sanches
- Sanches
- Sanches
- Sanches
- SchÀfer
- Spettmann
- Van der Bruggen
- Vanessa J. Pereira
- VĂtor Vale Cardoso
- Wols
- Wong
- Wong
- Wu
- Xu
- Xu
- Yangali-Quintanilla
- Younes
- Zhang
- Zularisam
- Publication venue
- 'Elsevier BV'
- Publication date
- Field of study
Electrospinning of Gelatin/Poly (Vinyl Pyrrolidone) Blends from Water/Acetic Acid Solutions
- Author
- Bhardwaj N
- Cameron LC
- Chang WM
- Chew SY
- Christiane Bertachini Lombello
- Chronakis IS
- Davanço T.
- Garg K
- Gasaymeh SS
- Geng X
- Gu SY
- Gómez-Guillén MC
- Han T
- Hassouna F
- Huang Z-M
- Karavas E
- Kong L
- Kulkarni A
- Lv N
- Malmonge SM
- Marcos Akira d'Ăvila
- Mattos RI
- Okutan N
- Panzavolta S
- Parker NG
- Ramakrishna S
- Reis C.
- Schrieber R
- Sell SA
- Senne MI
- Sill TJ
- Simone S
- Sionkowska A
- Sionkowska A
- Sionkowska A
- Song JH
- Tais Helena Costa Salles
- Thompson CJ
- Uyar T
- Van der Schueren L
- Vieira DF
- Wahyudiono MS
- Xu F
- Yamazaki CM
- Zhang PY
- Zhi X
- Publication venue
- 'FapUNIFESP (SciELO)'
- Publication date
- Field of study
A922 Sequential measurement of 1 hour creatinine clearance (1-CRCL) in critically ill patients at risk of acute kidney injury (AKI)
- Author
- Abbott TE
- Abdallah RI
- Abdel-Aal IR
- Abdelmonem SA
- Abdo WF
- Abellan AN
- AbellĂĄn AN
- AbellĂĄn AN
- AbellĂĄn AN
- Abrams ST
- Ackerley C
- Acuña M
- Adda M
- Adhikari NK
- Adriano G
- Adrie C
- Affatato R
- Affatato R
- Afonso-Rivero D
- Agarossi A
- Agarwal LK
- Ageeva T
- Agrawal R
- Aguayo-DeHoyos E
- Aguilar AL
- Aguilar-Alonso E
- Aguilar-Alonso E
- Aguilar-Alonso E
- Aguirregabyria M
- Ahmadnia E
- Ahn C
- Ahn JY
- Ahn JY
- Ahn MY
- Ahn MY
- Aitken LM
- Akalaev R
- Akbarzadeh A
- Akcan-Arikan A
- Akhlagh SH
- Akhtar N
- AKI Research Group
- Akiduki N
- Akin S
- Akizuki N
- Akkoc T
- Ala-Kokko T
- Alanio A
- Albaiceta GM
- Albaladejo P
- Alberto F
- Albuisson E
- Alcala MA
- AlcĂĄzar L
- Aldabo-Pallas T
- Aldana NN
- Aldecoa C
- AlegrĂa L
- Alejandro R
- Alejo GC
- Alejos RM
- Alexandrova E
- Algarte R
- Algarte R
- Algieri I
- Algora-Weber A
- Alhamdi Y
- Aliaga FA
- Aliberti S
- Alkan A
- Almudena PM
- Almudevar PM
- Almudevar PM
- Almudévar PM
- Altıntas ND
- Alvarez J
- Alves SC
- Alzola LM
- Amargianitakis V
- Amaro R
- Amato MB
- Ambler M
- Amerongen MP
- Amininejad T
- Amor LL
- Amorim V
- Anand RK
- Andersen LW
- Andersson S
- Andoh K
- Andrade AH
- Andrade AH
- Andrade AH
- Andrade G
- Andreis DT
- Andreis DT
- Annane D
- Antonelli M
- Antoniadou A
- Antonio C
- Antonucci E
- AntĂłn DG
- Anzueto A
- Appiani F
- Aquevedo A
- Aragon C
- Araujo NJ
- Araujo VF
- ARIAM registry of adult cardiac surgery
- ARIAM-ANDALUCIA
- Arias CC
- Arias N
- Arias-Verdu MD
- Arias-Verdu MD
- Arias-Verdu MD
- Armaganidis A
- Arora MK
- Arora N
- Arrigo M
- Arslantas MK
- Artiguenave M
- Aslanian P
- Aspide R
- Asyralyyeva G
- Ataman S
- Ataman S
- Atchade E
- Atchade E
- Atchasiri S
- Athapattu P
- Atkins G
- Aublanc M
- Aublanc M
- Augustin P
- Augustin P
- Auquier P
- Avilés-Jurado FX
- Avramidis V
- Ayala LY
- Aydin M
- Azevedo JC
- Azevedo JR
- Aznar GP
- Babalis D
- Babini G
- Bachli EB
- Bader A
- Bader A
- Baena J
- Baidya DK
- Baikova VN
- Bakker J
- BalcĂĄzar LC
- BalcĂĄzar LC
- Baldassarri R
- Baldwin CE
- Balik M
- Ball I
- Ballin A
- Balsera B
- Banderas-Bravo ME
- Banderas-Bravo ME
- Bandert A
- Bangstad IL
- Baptista N
- Baquero JD
- Barbadillo S
- Barberet G
- Barberet G
- Barberet G
- Barbier J
- Barcenilla F
- Barea-Mendoza JA
- Barinas OD
- Baron AV
- Barrachina LG
- Barral M
- Basile-Filho A
- Bassi GL
- Bates D
- Battistini M
- Bauer M
- Bauer PR
- Baumstarck K
- Baumstarck K
- Bawin M
- Bazan N
- Bañeras J
- Beane A
- Beduneau G
- Beduneau G
- Beduneau G
- Beeharry SD
- Beerepoot M
- Begzjav T
- Beishuizen A
- Bell C
- Belletti A
- Bellissimo-Rodrigues F
- Belloli A
- Bellomo R
- Bellver BQ
- Belmonte R
- Ben-Hamouda N
- Bendel S
- Bendel S
- Benyamina M
- Beretta S
- Berg R
- Bergantino B
- Berghmans J
- Bernal FF
- Berric A
- Berrutti D
- Berthelsen RE
- Bertini P
- Bertini P
- Berto MB
- Besevli SG
- Bestle MH
- Bettex D
- Bettex DA
- Beunders R
- Bhasin D
- Bhattal MK
- Bhide S
- Bianchi I
- Bianchi I
- Bianzina S
- Bianzina S
- Bianzina S
- Bishop J
- Bissenova N
- Bisso MC
- Blans MJ
- Blobner M
- Bloomer MJ
- Blot K
- Blot S
- Blot S
- Boa F
- Bobi Q
- Bodingbauer M
- BodĂ M
- Boer C
- Bogossian E
- Bonet S
- Bonn M
- Bonnet M
- Borges FK
- Bouadma L
- Boucekine M
- Bougouin W
- Bourenne J
- Boyd JG
- Boyd JG
- Bozbay S
- Bozza F
- Bradac O
- Brandon RA
- Brandon RB
- Braschi A
- Braschi A
- Braschi A
- Brasseur A
- Brasseur A
- Brasseur A
- Braune S
- Brazzi L
- Breitkreutz R
- Brianti R
- Brioni M
- Brochard L
- Brochard L
- Brochard L
- Brock N
- Brody DL
- Brook R
- Brousseau C
- Brown K
- Brugger SC
- Brugger SC
- Bruno F
- Bruno K
- Brusasco C
- Brusasco C
- Brusasco C
- Bruyere O
- Bucknall T
- Buddi S
- Buise M
- Buitinck SH
- Buranavanich P
- Bureau C
- Burle JF
- Burtin P
- Busico M
- Butler MB
- Butrov AV
- Caballero CH
- Caballero J
- Cabello JT
- Cabello JT
- Cabrera AR
- Cabrera JL
- Cabrera JL
- Cabrini L
- Cairus C
- Cakin O
- Caliskan K
- Calpe P
- Calvo CP
- Calvo SA
- Camargo M
- Cambronero JA
- Cameron C
- Campbell R
- Campelo FA
- Campelo FA
- Campos LM
- Cannesson M
- CAPCRI Study
- Capellier G
- Carbonara M
- Cardellino S
- Cardenas CL
- Cariou A
- Cariou A
- Carlesso E
- Carmona AF
- Carmona SA
- Carmona SA
- Carmona SA
- Carmona SA
- Carone M
- Carpio D
- CarratalĂĄ A
- Carreira MM
- Carrero-GĂłmez F
- Carreño ER
- Carreño R
- Carvalho JP
- Carvalho KV
- Casals XN
- Casals XN
- Cassina T
- Castañeda DP
- Castellana D
- Castellanos A
- Castellanos A
- Castillo-Lorente E
- Castillo-Lorente E
- Catalan M
- CatalĂĄn RM
- Catena E
- Catena E
- Cauwenberghs H
- Cavalcanti D
- Cavalheiro AM
- Cavalier E
- Cavicchi FZ
- Cavicchi FZ
- Cengiz M
- Ceriani R
- Cermelli S
- CeroviÄ O
- Cha YS
- Chabanne R
- Chacon-Alves S
- Champigneulle B
- Champigneulle B
- Chan KC
- Chan KK
- Chan WS
- Chang CH
- Chang WY
- Chao A
- Chao A
- Chao AS
- Chao HC
- Chaouat M
- Charitidou E
- Charpentier C
- Charpentier J
- Charron C
- Chatelon J
- Chaudhari HK
- Chaussard M
- Chavanon O
- Chaves S
- Chelly J
- Chemam S
- Chen CM
- Chen CM
- Chen CW
- Chen CW
- Chen GQ
- Chen L
- Chen YS
- Chen YS
- Chen YS
- Cheng CC
- Cheng CC
- Cheng CC
- Cheng CC
- Cheng KC
- Cheng YJ
- Chernyshuk S
- Chevret S
- Chhor V
- Chiang CC
- Chiang CH
- Chiang CH
- Chiang CH
- Chiappa C
- Chiou KR
- Chiou KR
- Chiou KR
- Chiu LC
- Chiumello D
- Chiurazzi C
- Chiurazzi C
- Cho Y
- Cho YJ
- Cho YJ
- Choi JY
- Choi JY
- Choi KS
- Choi S
- Choi YJ
- Choi YY
- Chok L
- Cholkraisuwat J
- Cholley B
- Chondropoulos S
- Chou W
- Chouris I
- Chouvarda I
- Christopher KB
- Chrétien JM
- Chrétien JM
- Chrétien JM
- Chumaev A
- Chung CR
- Churchill K
- Chytas A
- Cinel I
- Cinnella G
- Citerio G
- Citerio G
- Clavel M
- Clemente EA
- Clermont G
- Cleyet M
- Cohen Y
- Colaprico A
- Colino L
- Collange O
- Colombo A
- Colombo A
- Colson P
- Combes A
- Concha P
- Connolly B
- Constan A
- Constan A
- Constan A
- Conte V
- Conti G
- Conti G
- Contreras KM
- Contreras MR
- Cook DJ
- Coombs M
- Cordeiro CP
- Cordero M
- Cordolcini V
- Cordovilla-Guardia S
- CordĂłn J
- Corona A
- Corona A
- Corradi F
- Corradi F
- Corradi F
- Correa-Chamorro E
- Corte FD
- Cortes ML
- Corzo L
- Coss-Bu JA
- Coss-Bu JA
- Costa MI
- Costa RC
- Costa RC
- Costa RC
- Costanzo E
- Cotoia A
- Cottini SR
- Cottle D
- Cotton H
- Cotton H
- Courant P
- Cowan R
- Creagh-Brown B
- Cressoni M
- Creteur J
- Creteur J
- Creteur J
- Creteur J
- Creteur J
- Creteur J
- Creteur J
- Creteur J
- Crimella F
- Cron N
- Cuellar AI
- Cui N
- Cunha MM
- Curiel-Balsera E
- Curiel-Balsera E
- Curinga M
- Curtis A
- Cuthbertson BH
- Cutuli SL
- CĂąmara M
- D'Arsigny C
- da Silva SL
- da Silva VZ
- Daga-Ruiz D
- Dalhuisen A
- Dalorzo M
- Damas P
- Dambrosio M
- DamÄs JK
- Das Neves A
- David H
- Davis C
- Davis P
- Day A
- de Abreu MG
- De Backer A
- De Brito-Ashurst I
- De Cassai A
- De Freitas FF
- De Gasperi A
- de Hoyos EA
- De la Calle-Pedrosa N
- de la Fuente MV
- De La Fuente-Martos C
- De La Fuente-Martos C
- De La Rica AS
- De la Torre MA
- De Maglie M
- De Maglie M
- de Molina FJ
- De Morton N
- de Oca Sandoval MA
- De Pascale G
- De Rosa S
- De Sanctis F
- De Silva AP
- De Sousa I
- de Vera AP
- de Wilde W
- De Zani D
- Deblier I
- DeBrunnar R
- Del Arco A
- Del Moral OL
- Del Olmo R
- Del Rosario CG
- Del Sorbo L
- Delgado CP
- Delgado MJ
- Delgado-Amaya M
- Demirkiran O
- Demoule A
- Denehy L
- Der Kinderen EP
- Descotte E
- Deshpande K
- Desmard M
- Desmard M
- Deveugele M
- Deye N
- Di Bello F
- Di Giancamillo M
- Di Gravio V
- Di Gregorio A
- Di Mussi R
- Di Rosso R
- Diaz DD
- Diaz P
- Dilek M
- Dilly MP
- Dima E
- Dimitroulakis K
- Dimitrov BD
- Dimitrov BD
- Dimopoulou IK
- Dinh A
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- ENVIN-HELICS Study Group
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- Ignacio ML
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- Japan Septic Disseminated Intravascular Coagulation (JSEPTIC DIC) study group
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- Jayasinghe S
- Jean-Baptiste S
- Jean-Baptiste S
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- Jensen JU
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- Jonas M
- Jonas M
- Jones C
- Joshi R
- Joshi V
- Jovaisa T
- JSEPTIC (Japanese Society of Education for Physicians and Trainees in Intensive Care) Clinical Trial Group
- Juan WC
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- Juez A
- Juliarena A
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- Kaminsky GE
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- Labra C
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- Ălvarez JT
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- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2016
- Field of study
Meeting abstrac
Effects of alirocumab on types of myocardial infarction: insights from the ODYSSEY OUTCOMES trial
- Author
- Abbas J
- Abbate A
- Abdullakutty J
- Abhyanakar AD
- Aboyans V
- Abrantes JAM
- Abu-Fadel M
- Acevedo M
- Adamkova V
- Adhyapak S
- Agarwal H
- Aggarwal R
- Aggarwal RK
- Aguirre A
- Ahmed H
- Ahremark U
- Ahuad Guerrero RA
- Aidar Ayoub JC
- Airaksinen JK
- Aitken D
- Akatova E
- Akhter F
- Ako J
- Akright L
- Akyea-Djamson A
- Al Joundi T
- Al-Windy NYY
- Alan D
- Alcocer Gamba MA
- Alexander JH
- Alexander K
- Alexandru TM
- Alings M
- Alonso Martin JJ
- Alvarisqueta AF
- Alves De Lima AE
- Amarasekera S
- Amarasena N
- Amir O
- Amlani M
- Amosova E
- Amuchastegui M
- Andersen K
- Andersen R
- Anderson J
- Ando K
- Angel Hominal M
- Annam S
- Anscombe R
- Apostolovic SR
- Appel K-F
- Arandjelovic A
- Araneda G
- Arango Benecke JL
- Arbel Y
- Arif I
- Armaganijan L
- Arroyo JAC
- Arstall MA
- Asanin MR
- Atar S
- Athyros V
- Auguadro C
- Ayala CAC
- Aylward PE
- Azizad MM
- Bagai A
- Bagriy A
- Bahit MC
- Bai F
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- Baldari D
- Balinovac J
- Ball E
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- Banuru S
- Barakovic F
- Baranov E
- Baranova E
- Barbarash OL
- Barbato E
- Barna OM
- Barone-Rochette G
- Barr C
- Barrucco R
- Bartels GL
- Bashir R
- Basson MMDV
- Bastos JM
- Bata I
- Batushkin V
- Bayat J
- Bayram Llamas EA
- Bayron C
- Beauloye C
- Bednarski J
- Behrens S
- Belhassane A
- Benedicto A
- Bengus CM
- Benov HO
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- Berglund S
- Berk M
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- Bittner VA
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- Blumberg EDS
- Boccara F
- Bodanese LC
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- Bokern MJJA
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- Bortnick A
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- Botelho RV
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- Budaj A
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- Busmane A
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- Carrillo Calvillo J
- Carroll PA
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- Caruso OC
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- Cequier Fillat AR
- Cerqueira MJAG
- Cestari HG
- Cevc M
- Cha J
- Chae I-H
- Chaitman B
- Chalavarya G
- Chaleff F
- Chambilla JMC
- Chandna H
- Chane M
- Chang M
- Chaudhary S
- Chavez V-CER
- Chen D
- Chen J
- Chen Y
- Cheng S-C
- Cheng X
- Chiang C-E
- Chiang C-E
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- Chopra VK
- Christenson S
- Chu A
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- Chumakova G
- Chumburidze V
- Civeira Murillo F
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- De Mora Martin M
- De Pellegrin A
- De Salazar DIM
- de Santos MON
- de Silva HA
- de Souza JA
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- DeVore AD
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- Dimov BI
- Dincic DV
- Ding C
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- Dodic S
- Dombrowski K
- Doncovska S
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- Dong Y
- Dorobantu M
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- Dran RD
- Drexel H
- Drzewiecka A
- Ducas J
- Ducrocq G
- Duda N
- Dujardin K
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- Zweiker R
- Publication venue
- 'Oxford University Press (OUP)'
- Publication date
- 01/01/2019
- Field of study
Aimsâ The third Universal Definition of Myocardial Infarction (MI) Task Force classified MIs into five types: Type 1, spontaneous; Type 2, related to oxygen supply/demand imbalance; Type 3, fatal without ascertainment of cardiac biomarkers; Type 4, related to percutaneous coronary intervention; and Type 5, related to coronary artery bypass surgery. Low-density lipoprotein cholesterol (LDL-C) reduction with statins and proprotein convertase subtilisinâkexin Type 9 (PCSK9) inhibitors reduces risk of MI, but less is known about effects on types of MI. ODYSSEY OUTCOMES compared the PCSK9 inhibitor alirocumab with placebo in 18Â 924 patients with recent acute coronary syndrome (ACS) and elevated LDL-C (â„1.8âmmol/L) despite intensive statin therapy. In a pre-specified analysis, we assessed the effects of alirocumab on types of MI. Methods and resultsâ Median follow-up was 2.8âyears. Myocardial infarction types were prospectively adjudicated and classified. Of 1860 total MIs, 1223 (65.8%) were adjudicated as Type 1, 386 (20.8%) as Type 2, and 244 (13.1%) as Type 4. Few events were Type 3 (nâ=â2) or Type 5 (nâ=â5). Alirocumab reduced first MIs [hazard ratio (HR) 0.85, 95% confidence interval (CI) 0.77â0.95; Pâ=â0.003], with reductions in both Type 1 (HR 0.87, 95% CI 0.77â0.99; Pâ=â0.032) and Type 2 (0.77, 0.61â0.97; Pâ=â0.025), but not Type 4 MI. Conclusionâ After ACS, alirocumab added to intensive statin therapy favourably impacted on Type 1 and 2 MIs. The data indicate for the first time that a lipid-lowering therapy can attenuate the risk of Type 2 MI. Low-density lipoprotein cholesterol reduction below levels achievable with statins is an effective preventive strategy for both MI types.For complete list of authors see http://dx.doi.org/10.1093/eurheartj/ehz299</p
Height and body-mass index trajectories of school-aged children and adolescents from 1985 to 2019 in 200 countries and territories: a pooled analysis of 2181 population-based studies with 65 million participants
- Author
- Abarca-Gomez Leandra
- Abdeen Ziad A
- Abdrakhmanova Shynar
- Abu-Rmeileh Niveen M
- Acosta-Cazares Benjamin
- Adams Robert J
- Aekplakorn Wichai
- Afsana Kaosar
- Afzal Shoaib
- Agdeppa Imelda A
- Aghazadeh-Attari Javad
- Aguilar-Salinas Carlos A
- Agyemang Charles
- Ahmad Mohamad Hasnan
- Ahmad Noor Ani
- Ahmadi Ali
- Ahmadi Naser
- Ahmed Soheir H
- Ahrens Wolfgang
- Aitmurzaeva Gulmira
- Ajlouni Kamel
- Al Nsour Mohannad
- Al-Hazzaa Hazzaa M
- Al-Othman Amani Rashed
- Al-Raddadi Rajaa
- Alarouj Monira
- AlBuhairan Fadia
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- Chetrit Angela
- Chikova-Iscener Ekaterina
- Chinh Nguyen Huu
- Chiolero Arnaud
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- Khaw Kay-Tee
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- Khuong Quynh Long
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- Metspalu Andres
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- Mohammadpourhodki Reza
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- Palloni Alberto
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- Petrauskiene Ausra
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- Pettenuzzo Emanuela
- Peykari Niloofar
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- Quang Ngoc La
- Quang Ngoc Nguyen
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- Rahim Hanan F Abdul
- Rahim Norsyamlina Che Abdul
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- Rahman Mahfuzar
- Rahman Mahmudur
- Raitakari Olli
- Raj Manu
- Rakhimova Ellina
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- Rampal Sanjay
- Rao Kodavanti Mallikharjuna
- Rao Sudha Ramachandra
- Rarra Vayia
- Rascon-Pacheco Ramon A
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- Rech Cassiano Ricardo
- Redon Josep
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- Regecova Valeria
- Revilla Luis
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- Slowikowska-Hilczer Jolanta
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- Stratton Gareth
- Stronks Karien
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- Sturua Lela
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- Wang Ming-Dong
- Wang Ningli
- Wang Qian
- Wang Xiangjun
- Wang Ya Xing
- Wang Ying-Wei
- Wannamethee S Goya
- Wareham Nicholas
- Weber Adelheid
- Wedderkopp Niels
- Weerasekera Deepa
- Weghuber Daniel
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- Willeit Johann
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- Wong Tien Yin
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- Woo Jean
- Woodward Mark
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- Xu Haiquan
- Xu Liang
- Yaacob Nor Azwany
- Yamborisut Uruwan
- Yan Weili
- Yang Ling
- Yang Xiaoguang
- Yang Yang
- Yardim Nazan
- Yaseri Mehdi
- Yasuharu Tabara
- Ye Xingwang
- Yiallouros Panayiotis K
- Yoosefi Moein
- Yoshihara Akihiro
- You Qi Sheng
- You San-Lin
- Younger-Coleman Novie O
- Yusof Safiah Md
- Yusoff Ahmad Faudzi
- Yusoff Muhammad Fadhli Mohd
- Zaccagni Luciana
- Zafiropulos Vassilis
- Zainuddin Ahmad A
- Zainuddin Ahmad A
- Zakavi Seyed Rasoul
- Zamani Farhad
- Zambon Sabina
- Zampelas Antonis
- Zamrazilova Hana
- Zapata Maria Elisa
- Zargar Abdul Hamid
- Zaw Ko Ko
- Zdrojewski Tomasz
- Zeng Yi
- Zhang Luxia
- Zhang Zhen-Yu
- Zhao Dong
- Zhao Ming-Hui
- Zhao Wenhua
- Zhen Shiqi
- Zheng Wei
- Zheng Yingfeng
- Zholdin Bekbolat
- Zhou Bin
- Zhou Maigeng
- Zhu Dan
- Zocalo Yanina
- Zuziak Monika
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2020
- Field of study
Summary Background Comparable global data on health and nutrition of school-aged children and adolescents are scarce. We aimed to estimate age trajectories and time trends in mean height and mean body-mass index (BMI), which measures weight gain beyond what is expected from height gain, for school-aged children and adolescents. Methods For this pooled analysis, we used a database of cardiometabolic risk factors collated by the Non-Communicable Disease Risk Factor Collaboration. We applied a Bayesian hierarchical model to estimate trends from 1985 to 2019 in mean height and mean BMI in 1-year age groups for ages 5â19 years. The model allowed for non-linear changes over time in mean height and mean BMI and for non-linear changes with age of children and adolescents, including periods of rapid growth during adolescence. Findings We pooled data from 2181 population-based studies, with measurements of height and weight in 65 million participants in 200 countries and territories. In 2019, we estimated a difference of 20 cm or higher in mean height of 19-year-old adolescents between countries with the tallest populations (the Netherlands, Montenegro, Estonia, and Bosnia and Herzegovina for boys; and the Netherlands, Montenegro, Denmark, and Iceland for girls) and those with the shortest populations (Timor-Leste, Laos, Solomon Islands, and Papua New Guinea for boys; and Guatemala, Bangladesh, Nepal, and Timor-Leste for girls). In the same year, the difference between the highest mean BMI (in Pacific island countries, Kuwait, Bahrain, The Bahamas, Chile, the USA, and New Zealand for both boys and girls and in South Africa for girls) and lowest mean BMI (in India, Bangladesh, Timor-Leste, Ethiopia, and Chad for boys and girls; and in Japan and Romania for girls) was approximately 9â10 kg/m2. In some countries, children aged 5 years started with healthier height or BMI than the global median and, in some cases, as healthy as the best performing countries, but they became progressively less healthy compared with their comparators as they grew older by not growing as tall (eg, boys in Austria and Barbados, and girls in Belgium and Puerto Rico) or gaining too much weight for their height (eg, girls and boys in Kuwait, Bahrain, Fiji, Jamaica, and Mexico; and girls in South Africa and New Zealand). In other countries, growing children overtook the height of their comparators (eg, Latvia, Czech Republic, Morocco, and Iran) or curbed their weight gain (eg, Italy, France, and Croatia) in late childhood and adolescence. When changes in both height and BMI were considered, girls in South Korea, Vietnam, Saudi Arabia, Turkey, and some central Asian countries (eg, Armenia and Azerbaijan), and boys in central and western Europe (eg, Portugal, Denmark, Poland, and Montenegro) had the healthiest changes in anthropometric status over the past 3·5 decades because, compared with children and adolescents in other countries, they had a much larger gain in height than they did in BMI. The unhealthiest changesâgaining too little height, too much weight for their height compared with children in other countries, or bothâoccurred in many countries in sub-Saharan Africa, New Zealand, and the USA for boys and girls; in Malaysia and some Pacific island nations for boys; and in Mexico for girls. Interpretation The height and BMI trajectories over age and time of school-aged children and adolescents are highly variable across countries, which indicates heterogeneous nutritional quality and lifelong health advantages and risks
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- Abbiendi G
- Abbrescia M
- Abdullin S
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- Singh J
- Singovsky A
- Sinthuprasith T
- Sirois Y
- Siroli G
- Sirunyan AM
- Skhirtladze N
- Skuja A
- Slaunwhite J
- Smirnov I
- Smirnov V
- Smith J
- Smith JG
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- Smith VJ
- Smith WH
- Snigirev A
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- Snook B
- Snow GR
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- Soares MS
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- Souza MHG
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- Spiridonov A
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- Sprenger D
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- Staykova Z
- Steggemann J
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- SteinbrĂŒck G
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- Stephans GSF
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- Stober FM
- Stolin V
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- Strauss J
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- SĂĄnchez-HernĂĄndez A
- Tabarelli De Fatis T
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- Tatarinov A
- Taurok A
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- Teo WD
- Teodorescu L
- Teyssier D
- Thea A
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- Tiras E
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- Trocino D
- Trocsanyi ZL
- Troendle D
- Tropiano A
- Troshin S
- Tsamalaidze Z
- Tsang KV
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- Tsirou A
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- Tully C
- Tumasyan A
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- Tuominen E
- Tuominiemi J
- Tuovinen E
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- Turkewitz J
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- Tuuva T
- Tuve C
- Twedt E
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- Tzeng YM
- Ujvari B
- Ulmer KA
- Ulrich R
- Ungaro D
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- Veszpremi V
- Vesztergombi G
- Veverka J
- Vidal Marono M
- Vidal R
- Vila I
- Vilar Cortabitarte R
- Vilela Pereira A
- Villasenor-Cendejas LM
- Villella I
- Vinogradov A
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- Viret S
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- Vishnevskiy D
- Vitulo P
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- Vlasov E
- Vlimant JR
- Vodopiyanov I
- Vogel H
- Volkov A
- Volobouev I
- Volodko A
- Volpe R
- Vorobiev I
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- Vuosalo C
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- Wissing C
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- Womersley WJ
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- Zuranski A
- Publication venue
- Publication date
- 02/03/2018
- Field of study
- âŠ