537 research outputs found
Air/water interfacial assembled rubbery semiconducting nanofilm for fully rubbery integrated electronics
- Author
- Publication venue
- 'American Association for the Advancement of Science (AAAS)'
- Publication date
- 01/09/2020
- Field of study
A rubber-like stretchable semiconductor with high carrier mobility is the most important yet challenging material for constructing rubbery electronics and circuits with mechanical softness and stretchability at both microscopic (material) and macroscopic (structural) levels for many emerging applications. However, the development of such a rubbery semiconductor is still nascent. Here, we report the scalable manufacturing of high-performance stretchable semiconducting nanofilms and the development of fully rubbery transistors, integrated electronics, and functional devices. The rubbery semiconductor is assembled into a freestanding binary-phased composite nanofilm based on the air/water interfacial assembly method. Fully rubbery transistors and integrated electronics, including logic gates and an active matrix, were developed, and their electrical performances were retained even when stretched by 50%. An elastic smart skin for multiplexed spatiotemporal mapping of physical pressing and a medical robotic hand equipped with rubbery multifunctional electronic skin was developed to show the applications of fully rubbery-integrated functional devices
Genomic and proteomic analyses of Mycobacterium bovis BCG Mexico 1931 reveal a diverse immunogenic repertoire against tuberculosis infection
- Author
- A P León
- A P León
- Adriana Arvizu
- AI Castillo-Rodal
- AS Leung
- AS Pym
- B Heym
- BB Trunz
- CM Sassetti
- D Charlet
- D Hayashi
- D Hayashi
- E Mendoza-Coronel
- G Bai
- G Molina-Olvera
- GG Mahairas
- Guillermo Mendoza-Hernández
- Instituto-Nacional-de-Higiene
- Ismael L Hernández-González
- J Bedwell
- J Fernández d Castro
- J Liu
- J Lynett
- J Sosa
- JTBaMG Sonnenberg
- K Liu
- K Liu
- K Rutherford
- KB Walker
- KN Lewis
- LY Armitige
- M Berriman
- M Rodriguez-Alvarez
- M Rodriguez-Alvarez
- M Seki
- MA Behr
- MA Behr
- MC Garcia Pelayo
- Miguel A Cevallos
- MS Alam
- MS Glickman
- OH Vandal
- Patricia Orduña
- PE Fine
- PR Jungblut
- R Brosch
- R Brosch
- R Kozak
- RK Aziz
- RT Glover
- Samuel Ponce de León
- SL Sampson
- T Hsu
- T Oettinger
- T Parish
- V Rao
- WHO
- Yolanda López-Vidal
- Publication venue
- BioMed Central
- Publication date
- 01/01/2011
- Field of study
<p>Abstract</p> <p>Background</p> <p>Studies of <it>Mycobacterium bovis </it>BCG strains used in different countries and vaccination programs show clear variations in the genomes and immune protective properties of BCG strains. The aim of this study was to characterise the genomic and immune proteomic profile of the BCG 1931 strain used in Mexico.</p> <p>Results</p> <p>BCG Mexico 1931 has a circular chromosome of 4,350,386 bp with a G+C content and numbers of genes and pseudogenes similar to those of BCG Tokyo and BCG Pasteur. BCG Mexico 1931 lacks Region of Difference 1 (RD1), RD2 and N-RD18 and one copy of IS6110, indicating that BCG Mexico 1931 belongs to DU2 group IV within the BCG vaccine genealogy. In addition, this strain contains three new RDs, which are 53 (RDMex01), 655 (RDMex02) and 2,847 bp (REDMex03) long, and 55 single-nucleotide polymorphisms representing non-synonymous mutations compared to BCG Pasteur and BCG Tokyo. In a comparative proteomic analysis, the BCG Mexico 1931, Danish, Phipps and Tokyo strains showed 812, 794, 791 and 701 protein spots, respectively. The same analysis showed that BCG Mexico 1931 shares 62% of its protein spots with the BCG Danish strain, 61% with the BCG Phipps strain and only 48% with the BCG Tokyo strain. Thirty-nine reactive spots were detected in BCG Mexico 1931 using sera from subjects with active tuberculosis infections and positive tuberculin skin tests.</p> <p>Conclusions</p> <p>BCG Mexico 1931 has a smaller genome than the BCG Pasteur and BCG Tokyo strains. Two specific deletions in BCG Mexico 1931 are described (RDMex02 and RDMex03). The loss of RDMex02 (<it>fadD23</it>) is associated with enhanced macrophage binding and RDMex03 contains genes that may be involved in regulatory pathways. We also describe new antigenic proteins for the first time.</p
Effectiveness of an intervention for improving drug prescription in primary care patients with multimorbidity and polypharmacy:Study protocol of a cluster randomized clinical trial (Multi-PAP project)
- Author
- Abad-Díez José María
- Alcaraz-Borrajo Marta
- Alcántara Ma Angelica Fajardo
- Algora Carmen Esteban
- Alonso Ana Sosa
- Alonso Ma Canto De Hoyos
- Ana Ballarín González Null
- Antón Ma Aránzazu Murciano
- Aranda Concepción García
- Arce Cesar Sánchez
- Ariza-Cardiel Gloria
- Arteaga Beatriz Caffarena de
- Aurioles Esther Martín
- Aza-Pascual-Salcedo Mercedes
- Azcoaga-Lorenzo Amaya
- Bandrés-Liso Ana Cristina
- Barnestein-Fonseca M Pilar
- Barroso Margarita Gómez
- Beneitez Ma Elisa Viñuela
- Bernal Javier Cuartero
- Blanco Ma Eloisa Rogero
- Borda Soledad Lorenzo
- Boxó-Cifuentes José Ramón
- Bujalance-Zafra M Josefa
- Calderón-Larrañaga Amaia
- Campillo Lourdes Visedo
- Catalina Sánchez Morales Null
- Cañavate Ma Dolores García Martínez
- Chasco Ma del Mar Loubet
- Clerencia-Sierra Mercedes
- Coscollar-Santaliestra Carlos
- De Blas González Francisca García
- de las Heras Esther Mateo
- de Letosa Ma Teresa Martín Nasarre
- De Mingo Enrique Rodríguez
- De Rivera Eva Martínez Cid
- del Cura-González Isabel
- del Pozo Carmen Sánchez Celaya
- Delgado Elena Mateo
- Delgado Noelia Sorinas
- Domínguez Susana García
- Elena Gascón del Prim Null
- Escalante Nieves Muñoz
- Escortell-Mayor Esperanza
- Fernández Cristóbal Trillo
- Fernández José Leiva
- Fernández Juan Carlos Moreno
- Fernández Raquel Mateo
- Fernández-Arquero José Manuel
- Flores Iliana Serrano
- Franco Alberto López García
- Galindo Jorge Olmedo
- Garach Elena Barceló
- García Eduardo Díaz
- García Esperanza Mora
- García Irene García
- García-Agua Nuria
- García-de Blas Francisca
- Garrido José Ignacio Torrente
- Genafo Jaime Sasporte
- Gimeno-Feliu Luis A.
- Gimeno-Miguel Antonio
- González Fernando Perales
- González Paulino Cubero
- González Rosario Iglesias
- González-González Ana Isabel
- González-Rubio Francisca
- Gorbea Carlos Bolea
- Guerra Francisco Serrano
- Gutiérrez José Fernando Tomás
- Gálvez Encarnación Peláez
- Gómez Belén Muñoz
- Gómez Deborah Gil
- Gómez José Luis Quintana
- Hamalainen Santiago Manuel Machín
- Hernández-Santiago Virginia
- Isabel Ma Soledad Núñez
- Izquierdo Javier Martín
- Jiménez Ma José Fernández
- Lafuente Marina Pinilla
- Laguna Amaya Nuria López
- Laguna-Berna Clara
- Laguno Lourdes Carolina Peláez
- Leiva-Fernández Francisca
- Llanos Pedro Sánchez
- Lorenzo Amaya Azcoaga
- Lucas Eustaquio Dendarieta
- Luz Pilar de la Mota Ybancos Null
- López Francisco Ramón Abellán
- López-León Ana Ma
- López-Rodríguez Juan A.
- López-Verde Fernando
- Ma Rosario Sanjuan Cortés Null
- Ma Teresa Delgado Marroquín Null
- Maqueda Rafael Ángel
- Marcos Claudia López
- Marengoni Alessandra
- Marta-Moreno Javier
- Martín Ma Victoria Asín
- Martín-Fernández Jesús
- Marzal Adolfo Cajal
- Mataix-San-Juan Ángel
- Mateos-Sancho Carmina
- Medina Ricardo De Felipe
- Mellado Ma del Mar Gil
- Mendaño Ma Carmen Molina
- Mendoza Leovigildo Ginel
- Miguel Valentina Martín
- Molina Ma José Gracia
- Morey-Montalvo Mariel
- Muth Christiane
- Márquez-Chamizo Maria Isabel
- Mínguez Sorio Ma del Pilar
- Naranjo Juana Morales
- Navarro Jiménez José Manuel
- Negre Antonio Luis Oto
- Ortiz Fernanda Morales
- Parrilla Ma Dolores Gallego
- Pascual Enrique Revilla
- Pascual Juan Pedro Calvo
- Peláez Ma Paloma Morso
- Peña Ma José Clavijo
- Pico-Soler Victoria
- Poblador-Plou Beatriz
- Polentinos-Castro Elena
- Poncel-Falcó Antonio
- Pradilla Ma Victoria Muñoz
- Prados-Torres Alexandra
- Prados-Torres Daniel
- Pérez Cristina Guisado
- Pérez Manuel Antonio Alonso
- Quintana José Porta
- Ramiro-González María D.
- Rico-Blázquez Milagros
- Rodríguez Antonia González
- Rodríguez Ma Jesús Sousa
- Rodríguez Ma José Alcaide
- Rodríguez Ma Luisa Moya
- Rodríguez-Barrientos Ricardo
- Rogero-Blanco Marisa
- Romero Virginia Castillo
- Royo Eugenio Galve
- Ruiz Sylvia Hazañas
- Ruiz-San-Basilio José Ma
- Rumayor-Zarzuelo Mercedes
- Ríos Irene Martínez
- Sainz Macarena Toro
- Salido Enrique Leonés
- Salvador Julio Sánchez
- Santaella Miguel Domínguez
- Sanz-Cuesta Teresa
- Serrano Beatriz López
- Suarez Esther Gómez
- Sánchez Jesús Ma Redondo
- Sánchez Teodoro Corrales
- Sánchez-Perruca Luis
- Taira Ma Begoña Abadía
- Tapia Purificación Magán
- Tello-Bernabé Ma Eugenia
- Torres Catalina Moreno
- Torres José Manuel Ramírez
- Torres Ma Antonia Máximo
- Valderas-Martínez José María
- Valdés Gloria Aycart
- Vargas Ana Ma Fernández
- Villalba Ma del Mar Álvarez
- Vázquez-Alarcón Rubén
- Wiesman Elisa Ceresuela
- Yépez Jeannet Dolores Sánchez
- Zapata Ma Isabel Ferrer
- Álvarez Juan Carlos García
- álvarez-Villalba Mar
- Álvaro Carlos Casado
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2017
- Field of study
This study was funded by the Fondo de Investigaciones Sanitarias ISCIII (Grant Numbers PI15/00276, PI15/00572, PI15/00996), REDISSEC (Project Numbers RD12/0001/0012, RD16/0001/0005), and the European Regional Development Fund ("A way to build Europe").Background: Multimorbidity is associated with negative effects both on people's health and on healthcare systems. A key problem linked to multimorbidity is polypharmacy, which in turn is associated with increased risk of partly preventable adverse effects, including mortality. The Ariadne principles describe a model of care based on a thorough assessment of diseases, treatments (and potential interactions), clinical status, context and preferences of patients with multimorbidity, with the aim of prioritizing and sharing realistic treatment goals that guide an individualized management. The aim of this study is to evaluate the effectiveness of a complex intervention that implements the Ariadne principles in a population of young-old patients with multimorbidity and polypharmacy. The intervention seeks to improve the appropriateness of prescribing in primary care (PC), as measured by the medication appropriateness index (MAI) score at 6 and 12months, as compared with usual care. Methods/Design: Design:pragmatic cluster randomized clinical trial. Unit of randomization: family physician (FP). Unit of analysis: patient. Scope: PC health centres in three autonomous communities: Aragon, Madrid, and Andalusia (Spain). Population: patients aged 65-74years with multimorbidity (≥3 chronic diseases) and polypharmacy (≥5 drugs prescribed in ≥3months). Sample size: n=400 (200 per study arm). Intervention: complex intervention based on the implementation of the Ariadne principles with two components: (1) FP training and (2) FP-patient interview. Outcomes: MAI score, health services use, quality of life (Euroqol 5D-5L), pharmacotherapy and adherence to treatment (Morisky-Green, Haynes-Sackett), and clinical and socio-demographic variables. Statistical analysis: primary outcome is the difference in MAI score between T0 and T1 and corresponding 95% confidence interval. Adjustment for confounding factors will be performed by multilevel analysis. All analyses will be carried out in accordance with the intention-to-treat principle. Discussion: It is essential to provide evidence concerning interventions on PC patients with polypharmacy and multimorbidity, conducted in the context of routine clinical practice, and involving young-old patients with significant potential for preventing negative health outcomes. Trial registration: Clinicaltrials.gov, NCT02866799Publisher PDFPeer reviewe
Search for squarks and gluinos in events with isolated leptons, jets and missing transverse momentum at s√=8 TeV with the ATLAS detector
- Author
- A Djouadi
- A Kulesza
- A Kulesza
- A Lazopoulos
- A Neveu
- A Neveu
- A Sherstnev
- A. A. E. Bannoura
- A. A. Elliot
- A. A. Grillo
- A. A. Komar
- A. A. Korol
- A. A. Maier
- A. A. Minaenko
- A. A. Nepomuceno
- A. A. Snesarev
- A. A. Solodkov
- A. A. Talyshev
- A. Aloisio
- A. Alonso
- A. Altheimer
- A. Amorim
- A. Andreazza
- A. Angerami
- A. Annovi
- A. Antonov
- A. Artamonov
- A. Ashkenazi
- A. B. Fenyuk
- A. Baroncelli
- A. Bassalat
- A. Basye
- A. Beddall
- A. Bellerive
- A. Bingul
- A. Bocci
- A. Bogouch
- A. Borisov
- A. Boveia
- A. Brandt
- A. Bruni
- A. Buzatu
- A. C. Bundock
- A. C. Daniells
- A. C. König
- A. C. Martyniuk
- A. C. Schaffer
- A. Calandri
- A. Campoverde
- A. Canepa
- A. Castelli
- A. Catinaccio
- A. Cattai
- A. Cerri
- A. Cervelli
- A. Chafaq
- A. Chegwidden
- A. Cheplakov
- A. Chilingarov
- A. Chitan
- A. Ciocio
- A. Clark
- A. Coccaro
- A. Corso-Radu
- A. Cortes-Gonzalez
- A. D. Hawkins
- A. D. Pilkington
- A. Dafinca
- A. Dattagupta
- A. De Salvo
- A. De Santo
- A. Dell’Acqua
- A. Demilly
- A. Dewhurst
- A. Di Ciaccio
- A. Di Domenico
- A. Di Girolamo
- A. Di Mattia
- A. Di Simone
- A. Dimitrievska
- A. Doria
- A. Dudarev
- A. Durglishvili
- A. E. Baas
- A. E. Barton
- A. E. Kiryunin
- A. E. Loevschall-Jensen
- A. Ereditato
- A. Ezhilov
- A. F. Saavedra
- A. Farbin
- A. Farilla
- A. Favareto
- A. Ferrari
- A. Ferrer
- A. Ferretto Parodi
- A. Filipčič
- A. Firan
- A. Fischer
- A. Floderus
- A. Formica
- A. Forti
- A. G. Bogdanchikov
- A. G. Buckley
- A. G. Goussiou
- A. G. Leister
- A. G. Myagkov
- A. G. Olchevski
- A. Gabrielli
- A. Gabrielli
- A. Gemmell
- A. Gershon
- A. Glazov
- A. Gomes
- A. Gorišek
- A. Grohsjean
- A. Haas
- A. Hamilton
- A. Hasib
- A. Henrichs
- A. Hoecker
- A. Hoummada
- A. Hrynevich
- A. I. Butt
- A. I. Etienvre
- A. I. Mincer
- A. Irles Quiles
- A. J. Armbruster
- A. J. Barr
- A. J. Beddall
- A. J. Bevan
- A. J. Brennan
- A. J. Horton
- A. J. Lankford
- A. J. Lowe
- A. J. Tanasijczuk
- A. J. Turvey
- A. Jinaru
- A. Juste Rozas
- A. K. Ciftci
- A. K. Kopp
- A. K. Morley
- A. Kaczmarska
- A. Kamenshchikov
- A. Kapliy
- A. Karamaoun
- A. Kastanas
- A. Katre
- A. Khanov
- A. Kharlamov
- A. Khodinov
- A. Khomich
- A. Klimentov
- A. Knue
- A. Korn
- A. Kotwal
- A. Kourkoumeli-Charalampidi
- A. Koutsman
- A. Krasznahorkay
- A. Kravchenko
- A. Kruse
- A. Kugel
- A. Kuhl
- A. Kupco
- A. L. Maslennikov
- A. L. Read
- A. L. S. Schorlemmer
- A. L. Yen
- A. La Rosa
- A. Lehan
- A. Leisos
- A. Lewis
- A. Limosani
- A. Lipniacka
- A. Lister
- A. Lleres
- A. Loginov
- A. Lounis
- A. Lucotte
- A. M. Cooper-Sarkar
- A. M. Henriques Correia
- A. M. Leyko
- A. M. Litke
- A. M. Nairz
- A. M. Soukharev
- A. M. Zaitsev
- A. Macchiolo
- A. Madsen
- A. Maevskiy
- A. Maio
- A. Manfredini
- A. Mann
- A. Manousakis-Katsikakis
- A. Marzin
- A. Mastroberardino
- A. McCarn
- A. Mehta
- A. Mengarelli
- A. Messina
- A. Milic
- A. Milov
- A. Miucci
- A. Morton
- A. N. Karyukhin
- A. N. Sisakyan
- A. N. Tuna
- A. Nagarkar
- A. Negri
- A. Nelson
- A. Nikiforov
- A. Nisati
- A. Ochi
- A. Oh
- A. Olariu
- A. Olszewski
- A. Onofre
- A. Ouraou
- A. Ovcharova
- A. P. Colijn
- A. Pacheco Pages
- A. Palma
- A. Paramonov
- A. Passeri
- A. Petridis
- A. Picazio
- A. Pinder
- A. Pingel
- A. Policicchio
- A. Polini
- A. Poppleton
- A. Pranko
- A. Quadt
- A. Qureshi
- A. R. Davison
- A. R. Stradling
- A. R. Weidberg
- A. Redelbach
- A. Renaud
- A. Rimoldi
- A. Robichaud-Veronneau
- A. Robson
- A. Romaniouk
- A. Rozanov
- A. Ruiz-Martinez
- A. Ruschke
- A. S. Boldyrev
- A. S. Cerqueira
- A. S. Chisholm
- A. S. Hard
- A. S. Kozhin
- A. S. Mete
- A. S. Thompson
- A. Saddique
- A. Salamon
- A. Salnikov
- A. Salvucci
- A. Salzburger
- A. Sanchez
- A. Sansoni
- A. Sapronov
- A. Sbrizzi
- A. Schoening
- A. Schwartzman
- A. Seiden
- A. Sfyrla
- A. Shcherbakova
- A. Shmeleva
- A. Sidoti
- A. Sircar
- A. Soffer
- A. Soloshenko
- A. Sood
- A. Sopczak
- A. Straessner
- A. Strandlie
- A. Strubig
- A. Succurro
- A. T. Doyle
- A. T. Goshaw
- A. T. H. Arce
- A. T. Law
- A. T. Watson
- A. Taffard
- A. Tavares Delgado
- A. Tricoli
- A. Trzupek
- A. Tudorache
- A. Tykhonov
- A. Undrus
- A. Usanova
- A. V. Akimov
- A. V. Anisenkov
- A. Valero
- A. Vaniachine
- A. Vartapetian
- A. Ventura
- A. Venturini
- A. Vest
- A. Vogel
- A. Warburton
- A. Washbrook
- A. White
- A. Wildauer
- A. Wilson
- A. Yamamoto
- A. Yurkewicz
- A. Zaman
- A. Zemla
- A. Zhemchugov
- A. Zibell
- A. Zoccoli
- AH Chamseddine
- AL Read
- ATLAS collaboration
- ATLAS collaboration
- ATLAS collaboration
- ATLAS collaboration
- ATLAS collaboration
- ATLAS collaboration
- ATLAS collaboration
- ATLAS collaboration
- ATLAS collaboration
- ATLAS collaboration
- ATLAS collaboration
- ATLAS collaboration
- ATLAS collaboration
- ATLAS collaboration
- ATLAS collaboration
- ATLAS collaboration
- ATLAS collaboration
- ATLAS collaboration
- ATLAS collaboration
- ATLAS collaboration
- ATLAS collaboration
- ATLAS collaboration
- ATLAS collaboration
- B Cooper
- B. A. Dolgoshein
- B. A. Long
- B. A. Petersen
- B. A. Schumm
- B. Abbott
- B. Abi
- B. Alvarez Gonzalez
- B. Auerbach
- B. Axen
- B. B. Tannenwald
- B. Brau
- B. Brelier
- B. Burghgrave
- B. Butler
- B. C. Cerio
- B. Chapleau
- B. Cole
- B. D. Cooper
- B. D. Schoenrock
- B. Dechenaux
- B. Di Girolamo
- B. Di Micco
- B. E. Cox
- B. E. Lindquist
- B. Esposito
- B. G. Fulsom
- B. G. Pope
- B. Galhardo
- B. Gaur
- B. Giacobbe
- B. Gibbard
- B. Gorini
- B. H. Smart
- B. Heinemann
- B. J. Gallop
- B. J. O’Brien
- B. Jackson
- B. K. B. Chow
- B. K. Gjelsten
- B. K. Wosiek
- B. Kaplan
- B. Laforge
- B. Lemmer
- B. Lenzi
- B. Li
- B. Li
- B. Liberti
- B. Liu
- B. Lopez Paredes
- B. Lund-Jensen
- B. M. Barnett
- B. M. M. Allbrooke
- B. M. Waugh
- B. M. Wynne
- B. Malaescu
- B. Mandelli
- B. Mansoulie
- B. Martin
- B. Martin
- B. Martin dit Latour
- B. Meirose
- B. Mindur
- B. Nicquevert
- B. Osculati
- B. P. Kerševan
- B. Penning
- B. Pinto
- B. R. Mellado Garcia
- B. S. Acharya
- B. Sarrazin
- B. Schneider
- B. Simmons
- B. Sopko
- B. Stelzer
- B. Stugu
- B. T. King
- B. T. Winter
- B. Trocmé
- B. Vachon
- B. Walsh
- B. Weinert
- B. Yabsley
- B. Zabinski
- B. Zhou
- B. Åsman
- BC Allanach
- BP Kersevan
- C. A. Chavez Barajas
- C. A. Jung
- C. A. Lee
- C. A. Solans
- C. Alexa
- C. Alpigiani
- C. Amelung
- C. Anastopoulos
- C. B. Gwilliam
- C. Bacci
- C. Becot
- C. Belanger-Champagne
- C. Bernard
- C. Bernius
- C. Bertella
- C. Bertsche
- C. Betancourt
- C. Bini
- C. Blocker
- C. Bock
- C. Bohm
- C. Bourdarios
- C. C. Chau
- C. C. Ohm
- C. Chen
- C. Clement
- C. Conta
- C. Cuthbert
- C. Da Via
- C. Dallapiccola
- C. David
- C. Debenedetti
- C. Deluca
- C. Deterre
- C. Di Donato
- C. Doglioni
- C. Escobar
- C. F. Anders
- C. Feng
- C. Ferretti
- C. Friedrich
- C. Fukunaga
- C. G. Lester
- C. G. Zhu
- C. Gabaldon
- C. Galea
- C. García
- C. Gatti
- C. Gay
- C. Gemme
- C. Giuliani
- C. Glasman
- C. Goy
- C. Guicheney
- C. Gumpert
- C. Gutschow
- C. Guyot
- C. Gwenlan
- C. Gössling
- C. Haber
- C. Helsens
- C. Hengler
- C. Hsu
- C. Isaksson
- C. Issever
- C. J. Oram
- C. J. Potter
- C. J. S. Young
- C. Jeske
- C. Kourkoumelis
- C. L. Lampen
- C. Lacasta
- C. Lapoire
- C. Leggett
- C. Leonidopoulos
- C. Leroy
- C. Limbach
- C. Luci
- C. M. Buttar
- C. M. Delitzsch
- C. M. Hawkes
- C. M. Lester
- C. Maiani
- C. Maidantchik
- C. Malone
- C. Meineck
- C. Melachrinos
- C. Meroni
- C. Meyer
- C. Meyer
- C. Mills
- C. Monini
- C. N. P. Gee
- C. Nellist
- C. O. Shimmin
- C. Oropeza Barrera
- C. P. Bee
- C. P. Buszello
- C. P. Hays
- C. P. Marino
- C. P. Ward
- C. Padilla Aranda
- C. Pahl
- C. Petridou
- C. Pizio
- C. R. Boddy
- C. R. Royon
- C. Rangel-Smith
- C. Rembser
- C. Roda
- C. Rudolph
- C. S. Pollard
- C. Sandoval
- C. Santoni
- C. Sawyer
- C. Sbarra
- C. Schiavi
- C. Schillo
- C. Schmitt
- C. Schroeder
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- T. Sfiligoj
- T. Slavicek
- T. Spreitzer
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- T. T. Boek
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- T. Yamamura
- T. Yamanaka
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- W. Wiedenmann
- X. Chen
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- Y. Hernández Jiménez
- Y. Horii
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- Y. Inamaru
- Y. J. Schnellbach
- Y. Jiang
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- Y. Li
- Y. Liu
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- Y. Ming
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- Y. Yamazaki
- Y. Yang
- Y. Yasu
- Y. Zhao
- Y. Zhu
- Yu. A. Tikhonov
- Z. Barnovska
- Z. D. Greenwood
- Z. Dolezal
- Z. Gecse
- Z. H. Citron
- Z. Hajduk
- Z. Hubacek
- Z. Idrissi
- Z. J. Grout
- Z. Kohout
- Z. L. Ren
- Z. Liang
- Z. M. Karpova
- Z. Marshall
- Z. Rurikova
- Z. V. Krumshteyn
- Z. Vykydal
- Z. Weng
- Z. Yan
- Z. Zhang
- Z. Zhao
- Z. Zinonos
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2015
- Field of study
The results of a search for supersymmetry in final states containing at least one isolated lepton (electron or muon), jets and large missing transverse momentum with the ATLAS detector at the Large Hadron Collider are reported. The search is based on proton-proton collision data at a centre-of-mass energy s√=8 TeV collected in 2012, corresponding to an integrated luminosity of 20 fb−1. No significant excess above the Standard Model expectation is observed. Limits are set on supersymmetric particle masses for various supersymmetric models. Depending on the model, the search excludes gluino masses up to 1.32 TeV and squark masses up to 840 GeV. Limits are also set on the parameters of a minimal universal extra dimension model, excluding a compactification radius of 1/R c = 950 GeV for a cut-off scale times radius (ΛR c) of approximately 30
Lo glocal y el turismo. Nuevos paradigmas de interpretación.
- Author
- Andrade Romo Edmundo
- Avilez Pineda Hernando
- Barbosa Polanco Silvia del Carmen
- Bojórquez Vargas Alma Rafaela
- Brenner Ludger
- Carballo Guillén Elisa Malibé
- Castañeda Castro Rosalba
- Chavarría Solís Ma. Elvia
- Chávez Dagostino Rosa María
- Correa Reyes Juanita Martha Elena
- Cuevas Contreras Tomás J.
- Escalona-Ulloa Miguel Antonio
- Espinoza Sánchez Rodrigo
- Flores Trejo Juan Carlos
- Franco Gómez Yolanda
- Franco Maass Sergio
- Frausto Martínez Óscar
- Gerritsen Peter R. W.
- González Damián Alfonso
- González Neri Irma
- González Pérez Cándido
- González Torreros Lucía
- Guillén Argüelles Elisa
- Gutiérrez Estrada Marisa
- Hernández González Gisela Beatriz
- Jiménez Martínez Alfonso de Jesús
- López López Álvaro
- López Pardo Gustavo
- Magaña Carrillo Irma
- Maldonado Ibarra Oscar Alberto
- Martínez Cárdenas Rogelio
- Martínez Moreno Omaira Cecilia
- Morales González Magdalena
- Nava Bernal Gabino
- Osorio García Maribel
- Padín Fabeiro Carmen
- Palomino Villavicencio Bertha
- Peña Cortes Fernando Andrés
- Portal Valenzuela Belfor Fernando
- Quintero Venegas Gino Jafet
- Ramírez De La O Irma Luz
- Reynoso Rábago Alfonso
- Rivas Pérez Teresa de J.
- Ruiz Andrade José Gabriel
- Santander Luis Carlos
- Sosa Ferreira Ana Pricila
- Tovar Cabañas Rodrigo
- Valderrama Martínez Jorge Antonio
- Valenzuela Valdivieso Ernesto
- Valtierra Hernández Ariel
- Velázquez Romero María Guadalupe
- Verján Quiñones Ricardo
- Villanueva Sánchez Rafael
- Álvarez Juárez Thania Sttephanni
- Publication venue
- Academia Mexicana de Investigación Turística; Universidad de Guadalajara
- Publication date
- 01/01/2012
- Field of study
El estudio del turismo se realiza desde múltiples escalas y enfoques, este libro aborda muchos temas que es necesario discutir desde diversas perspectivas; es el caso de la reflexión sobre la propia disciplina y sus conceptos, así como los asuntos específicos referidos al impacto territorial, los tipos de turismo, las cuestiones ambientales, el tema de la pobreza, la competitividad, las políticas públicas, el papel de las universidades, las áreas naturales protegidas, la sustentabilidad, la cultura, el desarrollo, la seguridad, todos temas centrales documentados y expuestos con originalidad y dominio del asunto. Lo multiescalar es básico para la comprensión del sistema turístico, sistema formado de procesos globales, regionales y locales. El eje de discusión del libro es lo glocal, esa interacción entre lo nacional y local con lo global
Exploring the association between Trypanosoma cruzi infection in rural communities and environmental changes in the southern Gran Chaco
- Author
- Bargues MD
- Bucher EH
- Catalá SS
- Ceballos LA
- Chüit R
- Cécere MC
- David Eladio Gorla
- Diosque P
- Dujardin JP
- Gorla D
- Gorla DE
- Grau HR
- Gürtler RE
- Hernández ML
- Kulldorff MA
- Laura Hoyos
- Marcelo Cabido
- Mariana Laura Moreno
- Moncayo A
- Moreno M
- Noireau F
- Panzera F
- Pennington RT
- Piccinali R
- Picollo MI
- Pérez de Rosas A
- Schofield CJ
- Silvia Susana Catalá
- Sosa Estani S
- Zak MR
- Zak MR
- Publication venue
- 'FapUNIFESP (SciELO)'
- Publication date
- Field of study
A922 Sequential measurement of 1 hour creatinine clearance (1-CRCL) in critically ill patients at risk of acute kidney injury (AKI)
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- Abbott TE
- Abdallah RI
- Abdel-Aal IR
- Abdelmonem SA
- Abdo WF
- Abellan AN
- Abellán AN
- Abellán AN
- Abellán AN
- Abrams ST
- Ackerley C
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- Ahn MY
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- Akalaev R
- Akbarzadeh A
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- Akhlagh SH
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- AKI Research Group
- Akiduki N
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- ARIAM registry of adult cardiac surgery
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- Costa RC
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- Costanzo E
- Cotoia A
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- Creteur J
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- Cuellar AI
- Cui N
- Cunha MM
- Curiel-Balsera E
- Curiel-Balsera E
- Curinga M
- Curtis A
- Cuthbertson BH
- Cutuli SL
- Câmara M
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- da Silva VZ
- Daga-Ruiz D
- Dalhuisen A
- Dalorzo M
- Damas P
- Dambrosio M
- Damås JK
- Das Neves A
- David H
- Davis C
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- Day A
- de Abreu MG
- De Backer A
- De Brito-Ashurst I
- De Cassai A
- De Freitas FF
- De Gasperi A
- de Hoyos EA
- De la Calle-Pedrosa N
- de la Fuente MV
- De La Fuente-Martos C
- De La Fuente-Martos C
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- De Maglie M
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- de Molina FJ
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- de Oca Sandoval MA
- De Pascale G
- De Rosa S
- De Sanctis F
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- De Sousa I
- de Vera AP
- de Wilde W
- De Zani D
- Deblier I
- DeBrunnar R
- Del Arco A
- Del Moral OL
- Del Olmo R
- Del Rosario CG
- Del Sorbo L
- Delgado CP
- Delgado MJ
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- Demoule A
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- Descotte E
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- Di Gravio V
- Di Gregorio A
- Di Mussi R
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- Dimopoulou IK
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- El Hamid MA
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- El Sayed E
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- Elbers PW
- Elgendy M
- Eliet J
- Emmanuel J
- Emmerich M
- Encina B
- Endacott R
- Endacott R
- Engelberts D
- ENVIN-HELICS Study Group
- Erb J
- Erdogan M
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- Escórcio S
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- Esteban A
- Estella A
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- Fave G
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- Feijoo AM
- Feliot E
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- Fernandez R
- Fernandez-Zamora MD
- Fernández IF
- Fernández L
- Fernández MV
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- Fernández-Barat L
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- Fernández-Ortega JF
- Ferraz AB
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- Ferri F
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- Fiks T
- Fiks T
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- Filho CA
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- FINNRESUSCI Study Group
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- Fleischmann E
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- Fontenot T
- Forel JM
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- Fox B
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- Frithiof R
- Fritz C
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- Frontera PR
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- Fumagalli F
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- Gabán-Díez Á
- Gadgil S
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- Gaizauskas E
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- Gallego-Corpa AI
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- Garcia-Alvarez JM
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- García MF
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- García-Olivares P
- Garnacho-Montero J
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- Garrido EM
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- Gasparovic V
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- Gaudard P
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- Gavrychenko D
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- Genc D
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- Geri G
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- GETGAG/SEMICYUC
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- Gherli T
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- Giannantonio M
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- Gordo F
- Gordon M
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- Goto T
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- Gottlieb J
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- Grangé S
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- Grassi L
- Grasso S
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- Gutiérrez-Pizarraya A
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- Gálvez V
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- Gómez-Jiménez C
- Güven G
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- Henderson MA
- Hendra H
- Henschel B
- Heras G
- Hernandis V
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- Hernández G
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- Herpain A
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- Houzé S
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- Hraiech S
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- Hua Y
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- Hualde JB
- Hualde JB
- Hualde JB
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- Huang CH
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- Huang WC
- Hubbard A
- Huber W
- Huddart S
- Hull AM
- Hung CY
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- Huot B
- Husheer SL
- Hutchings S
- Hutchison R
- Hwang GS
- Hwang GS
- Ibañes PG
- Ibsen M
- Idei M
- Idei M
- Idone FA
- Iesu E
- Iesu E
- Iglesias-Santiago A
- Ignacio ML
- Iida A
- Iijima H
- Ilan R
- Ilyina V
- Imanaka H
- Inaloo S
- Ince C
- Iotti GA
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- IPREA Study Group
- Irazabal JM
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- Ishimatsu S
- Itenov TS
- Iwamoto M
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- Izdes S
- Jaber S
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- Jacques T
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- Jamali S
- Jang BH
- Janotka M
- Janotka M
- Janotka M
- Jansen D
- Jansen N
- Japan Septic Disseminated Intravascular Coagulation (JSEPTIC DIC) study group
- Jardim JJ
- Jardim M
- Jareño A
- Javadpour S
- Jayasinghe S
- Jean-Baptiste S
- Jean-Baptiste S
- Jensen AE
- Jensen JU
- Jeon YD
- Jeon YD
- Jeong IY
- Jeong IY
- Jeong WY
- Jeong WY
- Jian Z
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- Jibaja M
- Jimenez-Herrera MF
- Jiménez GJ
- Jo YH
- Joachim J
- Jochmans S
- John G
- Jonas M
- Jonas M
- Jonas M
- Jones C
- Joshi R
- Joshi V
- Jovaisa T
- JSEPTIC (Japanese Society of Education for Physicians and Trainees in Intensive Care) Clinical Trial Group
- Juan WC
- Juanas CA
- Judickas S
- Juez A
- Juliarena A
- Jun IG
- Jun IG
- Jung K
- Jung KW
- Junior JM
- Kaczirek K
- Kaese S
- Kalani N
- Kalenka A
- Kalfon P
- Kamali E
- Kaminsky GE
- Kaneko M
- Kang M
- Kang M
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- Kang PL
- Kang PL
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- Kang Y
- Kao KC
- Kappler F
- Kara A
- Karachi F
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- Karsten E
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- Kashiya S
- Kashyap R
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- Katabami K
- Katabami K
- Katabami K
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- Kavanagh BP
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- Kim HJ
- Kim JM
- Kim JM
- Kim JW
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- Kim KS
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- Kim KS
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- Kim W
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- Kirwan CJ
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- Ko SB
- Kobayashi A
- Koco E
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- Kodate A
- Kodate A
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- Kolnikova I
- Komuro T
- Kondili E
- Kongpolprom N
- Kooner G
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- Kosuk ME
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- Kouatchet A
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- Kox M
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- Krishna B
- Kristof J
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- Kruger A
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- Ku NS
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- Kuebler WM
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- Kulkarni AP
- Kumari BK
- Kumbamu A
- Kunze-Szikszay N
- Kurmukov IA
- Kurth T
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- Kurtz P
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- Kwon HM
- Kwon WY
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- Labra C
- Lacerda P
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- Lafaurie M
- Lafuente E
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- Lagos R
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- Lai CC
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- Lake K
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- Lapteva K
- Larsson JS
- Latini R
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- Latorre J
- Lattuada M
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- Laurent A
- Lauretta MP
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- Lavrentieva A
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- Lee S
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- Lee YJ
- Lee YJ
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- Legrand M
- Legrand M
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- Leitao AL
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- Leone M
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- Li SH
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- Lichtenstein D
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- Lin KC
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- Lischinsky A
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- Loizou C
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- Londoño JG
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- Lopez-Gude MJ
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- Lortat-Jacob B
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- Loudet CI
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- Lourido CM
- Lozano JA
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- Lucinio NM
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- Lukaszewicz AC
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- López MA
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- MacKay A
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- Mackey G
- MacPhee I
- Macrì M
- Madueño VP
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- Maekawa K
- Maekawa K
- Maekawa K
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- Maghsoudi B
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- Magnoni S
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- Maistry N
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- Mancebo J
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- Mariani M
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- Marine-Vidal J
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- Mariotti L
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- Marmanidou K
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- Martín-Loeches I
- Martín-Loeches I
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- Martínez L
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- Martínez M
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- Martínez-Carmona JF
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- Mejías CR
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- Menendez R
- Mengelle C
- Mercat A
- Mercat A
- Mercat A
- Mergulhão PJ
- Merino-Vega D
- Messenger D
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- Mezidi M
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- Midwinter MJ
- Mignot T
- Miguelena PR
- Mihara Y
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- Moon YJ
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- Mora-Ordóñez JM
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- Morán I
- Motos A
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- Okayama Research Investigation Organizing Network (ORION)investigators
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- Olavarria E
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- Olivares F
- Olkkola KT
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- Wijayatilake DS
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- WIND study group
- WIND study group
- Winder-Rhodes S
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- Yılmaz G
- Yilmazer F
- Yodice P
- Yokoyama M
- Yonis H
- Yonis H
- Yonis H
- Yoon SZ
- Yoruk F
- Yoshida K
- Yoshida T
- Yoshida T
- Yoshida T
- Yoshida T
- Yoshihiro S
- Yoshitake E
- You KM
- Youn AM
- Young A
- Yu KM
- Yumoto T
- Yuzawa J
- Yuzawa J
- Zabaletta WJ
- Zabini D
- Zahorec M
- Zaien I
- Zakynthinos S
- Zanello M
- Zani D
- Zarantonello F
- Zayas B
- Zepeda EM
- Zeroual N
- Zerva L
- Zhang J
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- Zhou JX
- Zhovnir V
- Zibandah N
- Zijlstra F
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- Zwaag J
- Zýková I
- Álvarez JT
- Álvarez-Lerma F
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2016
- Field of study
Meeting abstrac
Combined measurement of differential and total cross sections in the H → γγ and the H → ZZ* → 4ℓ decay channels at s=13 TeV with the ATLAS detector
- Author
- Aaboud M
- Aad G
- Abbott B
- Abdinov O
- Abeloos B
- Abhayasinghe DK
- Abidi SH
- Abouzeid OS
- Abraham NL
- Abramowicz H
- Abreu H
- Abulaiti Y
- Acharya BS
- Adachi S
- Adamczyk L
- Adelman J
- Adersberger M
- Adiguzel A
- Adye T
- Affolder AA
- Afik Y
- Agheorghiesei C
- Aguilar-Saavedra JA
- Ahmadov F
- Aielli G
- Akatsuka S
- Akilli E
- Akimov AV
- Alberghi GL
- Albert J
- Albicocco P
- Alconada Verzini MJ
- Alderweireldt S
- Aleksa M
- Aleksandrov IN
- Alexa C
- Alexopoulos T
- Alhroob M
- Ali B
- Alimonti G
- Alison J
- Alkire SP
- Allaire C
- Allbrooke BMM
- Allen BW
- Allport PP
- Aloisio A
- Alonso A
- Alonso F
- Alpigiani C
- Alshehri AA
- Alstaty MI
- Alvarez Gonzalez B
- Alviggi MG
- Amadio BT
- Amaral Coutinho Y
- Ambroz L
- Amelung C
- Amidei D
- Amor Dos Santos SP
- Amoroso S
- Amrouche CS
- Anastopoulos C
- Ancu LS
- Andari N
- Andeen T
- Anders CF
- Anders JK
- Anderson KJ
- Andreazza A
- Andrei V
- Anelli CR
- Angelidakis S
- Angelozzi I
- Angerami A
- Anisenkov AV
- Annovi A
- Antel C
- Anthony MT
- Antonelli M
- Antrim DJA
- Anulli F
- Aoki M
- Aperio Bella L
- Arabidze G
- Arai Y
- Araque JP
- Araujo Ferraz V
- Araujo Pereira R
- Arce ATH
- Ardell RE
- Arduh FA
- Arguin J-F
- Argyropoulos S
- Armbruster AJ
- Armitage LJ
- Armstrong A
- Arnaez O
- Arnold H
- Arratia M
- Arslan O
- Artamonov A
- Artoni G
- Artz S
- Asai S
- Asbah N
- Ashkenazi A
- Asimakopoulou EM
- Asquith L
- Assamagan K
- Astalos R
- Atkin RJ
- Atkinson M
- Atlas Collaboration
- Atlay NB
- Augsten K
- Avolio G
- Avramidou R
- Axen B
- Ayoub MK
- Azuelos G
- Baas AE
- Baca MJ
- Bachacou H
- Bachas K
- Backes M
- Bagnaia P
- Bahmani M
- Bahrasemani H
- Bailey AJ
- Baines JT
- Bajic M
- Bakalis C
- Baker OK
- Bakker PJ
- Bakshi Gupta D
- Baldin EM
- Balek P
- Balli F
- Balunas WK
- Balz J
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- Bandyopadhyay A
- Banerjee S
- Bannoura AAE
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- Barbe WM
- Barberio EL
- Barberis D
- Barbero M
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- Barisits M-S
- Barkeloo J
- Barklow T
- Barlow N
- Barnea R
- Barnes SL
- Barnett BM
- Barnett RM
- Barnovska-Blenessy Z
- Baroncelli A
- Barone G
- Barr AJ
- Barranco Navarro L
- Barreiro Guimarães Da Costa J
- Barreiro F
- Bartoldus R
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- Bartos P
- Basalaev A
- Bassalat A
- Bates RL
- Batista SJ
- Batlamous S
- Batley JR
- Battaglia M
- Bauce M
- Bauer F
- Bauer KT
- Bawa HS
- Beacham JB
- Beattie MD
- Beau T
- Beauchemin PH
- Bechtle P
- Beck HC
- Beck HP
- Becker K
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- Becot C
- Beddall A
- Beddall AJ
- Bednyakov VA
- Bedognetti M
- Bee CP
- Beermann TA
- Begalli M
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- Behera A
- Behr JK
- Bell AS
- Bella G
- Bellagamba L
- Bellerive A
- Bellomo M
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- Belotskiy K
- Belyaev NL
- Benary O
- Benchekroun D
- Bender M
- Benekos N
- Benhammou Y
- Benhar Noccioli E
- Benitez J
- Benjamin DP
- Benoit M
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- Bentvelsen S
- Beresford L
- Beretta M
- Berge D
- Bergeaas Kuutmann E
- Berger N
- Bergsten LJ
- Beringer J
- Berlendis S
- Bernard NR
- Bernardi G
- Bernius C
- Bernlochner FU
- Berry T
- Berta P
- Bertella C
- Bertoli G
- Bertram IA
- Besjes GJ
- Bessidskaia Bylund O
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- Zhao P
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- Zhao Z
- Zhemchugov A
- Zhou B
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- Zhu CG
- Zhu H
- Zhu HL
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- Zhuang X
- Zhukov K
- Zhulanov V
- Zibell A
- Zieminska D
- Zimine NI
- Zimmermann S
- Zinonos Z
- Zinser M
- Ziolkowski M
- Zobernig G
- Zoccoli A
- Zoch K
- Zorbas TG
- Zou R
- Zur Nedden M
- Zwalinski L
- Álvarez Piqueras D
- Åkesson TPA
- Šfiligoj T
- Ženiš T
- Živković L
- Publication venue
- Elsevier
- Publication date
- 01/01/2018
- Field of study
A combined measurement of differential and inclusive total cross sections of Higgs boson production is performed using 36.1 fb−1 of 13 TeV proton–proton collision data produced by the LHC and recorded by the ATLAS detector in 2015 and 2016. Cross sections are obtained from measured H→γγ and H→ZZ*(→4ℓ event yields, which are combined taking into account detector efficiencies, resolution, acceptances and branching fractions. The total Higgs boson production cross section is measured to be 57.0−5.9 +6.0 (stat.) −3.3 +4.0 (syst.) pb, in agreement with the Standard Model prediction. Differential cross-section measurements are presented for the Higgs boson transverse momentum distribution, Higgs boson rapidity, number of jets produced together with the Higgs boson, and the transverse momentum of the leading jet. The results from the two decay channels are found to be compatible, and their combination agrees with the Standard Model predictions
Search for supersymmetry in events with four or more leptons in √s =13 TeV pp collisions with ATLAS
- Author
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- Aad G
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- Zhemchugov A
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- Zibell A
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- Zimine NI
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- Zimmermann S
- Zinonos Z
- Zinser M
- Ziolkowski M
- Zobernig G
- Zoccoli A
- Zou R
- zur Nedden M
- Zwalinski L
- Álvarez Piqueras D
- Åkesson TPA
- Šfiligoj T
- Ženiš T
- Živković L
- Publication venue
- 'American Physical Society (APS)'
- Publication date
- 01/01/2018
- Field of study
Results from a search for supersymmetry in events with four or more charged leptons (electrons, muons and taus) are presented. The analysis uses a data sample corresponding to 36.1 fb −1 of proton-proton collisions delivered by the Large Hadron Collider at s √ =13 TeV and recorded by the ATLAS detector. Four-lepton signal regions with up to two hadronically decaying taus are designed to target a range of supersymmetric scenarios that can be either enriched in or depleted of events involving the production and decay of a Z boson. Data yields are consistent with Standard Model expectations and results are used to set upper limits on the event yields from processes beyond the Standard Model. Exclusion limits are set at the 95% confidence level in simplified models of General Gauge Mediated supersymmetry, where higgsino masses are excluded up to 295 GeV. In R -parity-violating simplified models with decays of the lightest supersymmetric particle to charged leptons, lower limits of 1.46 TeV, 1.06 TeV, and 2.25 TeV are placed on wino, slepton and gluino masses, respectively
Antiinflammatory Therapy with Canakinumab for Atherosclerotic Disease
- Author
- A Abbate
- A Abhyankar
- A Adams
- A Agafina
- A Akyea-Djamson
- A Alan
- A Alfieri
- A Alfrey
- A Alvarisqueta
- A Amos
- A Anadiotis
- A Anneveldt
- A Antolick
- A Arthur
- A Aslam
- Abaci F
- Abdullakutty J
- Abhaichand R
- Abib E Jr
- Aboufakher R
- Abrantes J
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- Acampora D
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- Accini Mendoza Jl
- Aceto L
- Acevedo B
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- Actis Mv
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- Adjic Nc
- Affaki Gs
- Agarwal Dk
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- Aguilar M
- Ahire N
- Ahmad I
- Ahmed Sh
- Ahn Y
- Aish B
- Aiub F
- Aiub J
- Ajax K
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- Al-Khalili F
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- Alfonso T
- Allen J
- Alllison Dc
- Almaliky T
- Amerena J
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- Andor M
- Angelova I
- Angiolillo D
- Anita S
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- Antonicelli R
- Aparicio Cv
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- Apostolovic S
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- Zineldine A.
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- Publication venue
- 'Massachusetts Medical Society'
- Publication date
- 01/01/2017
- Field of study
Background: Experimental and clinical data suggest that reducing inflammation without affecting lipid levels may reduce the risk of cardiovascular disease. Yet, the inflammatory hypothesis of atherothrombosis has remained unproved. Methods: We conducted a randomized, double-blind trial of canakinumab, a therapeutic monoclonal antibody targeting interleukin-1β, involving 10,061 patients with previous myocardial infarction and a high-sensitivity C-reactive protein level of 2 mg or more per liter. The trial compared three doses of canakinumab (50 mg, 150 mg, and 300 mg, administered subcutaneously every 3 months) with placebo. The primary efficacy end point was nonfatal myocardial infarction, nonfatal stroke, or cardiovascular death. RESULTS: At 48 months, the median reduction from baseline in the high-sensitivity C-reactive protein level was 26 percentage points greater in the group that received the 50-mg dose of canakinumab, 37 percentage points greater in the 150-mg group, and 41 percentage points greater in the 300-mg group than in the placebo group. Canakinumab did not reduce lipid levels from baseline. At a median follow-up of 3.7 years, the incidence rate for the primary end point was 4.50 events per 100 person-years in the placebo group, 4.11 events per 100 person-years in the 50-mg group, 3.86 events per 100 person-years in the 150-mg group, and 3.90 events per 100 person-years in the 300-mg group. The hazard ratios as compared with placebo were as follows: in the 50-mg group, 0.93 (95% confidence interval [CI], 0.80 to 1.07; P = 0.30); in the 150-mg group, 0.85 (95% CI, 0.74 to 0.98; P = 0.021); and in the 300-mg group, 0.86 (95% CI, 0.75 to 0.99; P = 0.031). The 150-mg dose, but not the other doses, met the prespecified multiplicity-adjusted threshold for statistical significance for the primary end point and the secondary end point that additionally included hospitalization for unstable angina that led to urgent revascularization (hazard ratio vs. placebo, 0.83; 95% CI, 0.73 to 0.95; P = 0.005). Canakinumab was associated with a higher incidence of fatal infection than was placebo. There was no significant difference in all-cause mortality (hazard ratio for all canakinumab doses vs. placebo, 0.94; 95% CI, 0.83 to 1.06; P = 0.31). Conclusions: Antiinflammatory therapy targeting the interleukin-1β innate immunity pathway with canakinumab at a dose of 150 mg every 3 months led to a significantly lower rate of recurrent cardiovascular events than placebo, independent of lipid-level lowering. (Funded by Novartis; CANTOS ClinicalTrials.gov number, NCT01327846.
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