7 research outputs found
Therapeutic targeting of HMGB1 during experimental sepsis modulates the inflammatory cytokine profile to one associated with improved clinical outcomes
- Author
- A Cassado Ados
- BA Reddi
- C Fleischmann
- CA Gogos
- CA Wild
- DJ Torpy
- E Theodorakis
- E Venereau
- EE Ghosn
- F Pene
- FA Bozza
- G Kleiner
- H Wang
- H Wang
- H Wen
- H Yang
- H Yang
- H Yu
- IE Dumitriu
- J Charoensup
- J Sunden-Cullberg
- JC Marshall
- JJ Marini
- JT Muenzer
- KR Diener
- KR Walley
- L Dejager
- L Ulloa
- LT Zhang
- LY Gamez-Diaz
- M Schiller
- M Suarez-Santamaria
- M Surbatovic
- MF Osuchowski
- ML Steinhauser
- MO Manley
- P Puneet
- P Qiu
- PM LeBlanc
- RK Aneja
- S Gaini
- S Karlsson
- S Lv
- S Oda
- SM Opal
- U Andersson
- V Urbonaviciute
- W Gong
- X Fan
- X Huang
- Z Xiao
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2017
- Field of study
Sepsis remains a significant health burden and a major clinical need exists for therapeutics to dampen the excessive and uncontrolled immune activation. Nuclear protein high mobility group box protein 1 (HMGB1) is released following cell death and is a late mediator in sepsis pathogenesis. While approaches targeting HMGB1 have demonstrated reduced mortality in pre-clinical models of sepsis, the impact of HMGB1 blockade on the complex septic inflammatory milieu and the development of subsequent immunosuppression remain enigmatic. Analysis of plasma samples obtained from septic shock patients established an association between increased HMGB1 and non-survival, higher APACHE II scores, and increased pro-inflammatory cytokine responses. Pre-clinically, administration of neutralising ovine anti-HMGB1 polyclonal antibodies improved survival in murine endotoxaemia and caecal ligation and puncture-induced sepsis models, and altered early cytokine profiles to one which corresponded to patterns observed in the surviving patient cohort. Additionally, anti-HMGB1 treated murine sepsis survivors were significantly more resistant to secondary bacterial infection and exhibited altered innate immune cell phenotypes and cytokine responses. These findings demonstrate that anti-HMGB1 antibodies alter inflammation in murine sepsis models and reduce sepsis mortality without potentiating immunosuppression.Natalie E. Stevens, Marianne J. Chapman, Cara K. Fraser, Tim R. Kuchel, John D. Hayball and Kerrilyn R. Diene
Comparison of the accuracy of neutrophil CD64, procalcitonin, and C-reactive protein for sepsis identification: a systematic review and meta-analysis
- Author
- A Dimoula
- A Gros
- A Luzzani
- AS Rosman
- B Uzzan
- BH Davis
- C Brun-Buisson
- C Wagner
- C-C Wu
- CL Sprung
- CM Rutter
- D Moher
- E Barth
- G Fischer
- I Muzlovic
- J Cid
- JB Reitsma
- JH Gerrits
- K-M Kaukonen
- KH Hsu
- LE Moses
- LY Gamez-Diaz
- M Godnic
- M Singer
- MM Levy
- NA Lai
- O Livaditi
- P Cardelli
- PC Ng
- PF Whiting
- PR Bauer
- R Ferrer
- S Gibot
- S Li
- S Righi
- SS Qureshi
- TL Tan
- VY Dombrovskiy
- X Wang
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Therapeutic targeting of HMGB1 during experimental sepsis modulates the inflammatory cytokine profile to one associated with improved clinical outcomes
- Author
- A Cassado Ados
- BA Reddi
- C Fleischmann
- CA Gogos
- CA Wild
- DJ Torpy
- E Theodorakis
- E Venereau
- EE Ghosn
- F Pene
- FA Bozza
- G Kleiner
- H Wang
- H Wang
- H Wen
- H Yang
- H Yang
- H Yu
- IE Dumitriu
- J Charoensup
- J Sunden-Cullberg
- JC Marshall
- JJ Marini
- JT Muenzer
- KR Diener
- KR Walley
- L Dejager
- L Ulloa
- LT Zhang
- LY Gamez-Diaz
- M Schiller
- M Suarez-Santamaria
- M Surbatovic
- MF Osuchowski
- ML Steinhauser
- MO Manley
- P Puneet
- P Qiu
- PM LeBlanc
- RK Aneja
- S Gaini
- S Karlsson
- S Lv
- S Oda
- SM Opal
- U Andersson
- V Urbonaviciute
- W Gong
- X Fan
- X Huang
- Z Xiao
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
A latent class approach for sepsis diagnosis supports use of procalcitonin in the emergency room for diagnosis of severe sepsis
- Author
- A Lever
- Adriana I Henao
- Alex Garcia
- AM Esper
- C Wacker
- Carlos I Gomez
- Clara M Arango
- D Limmathurotsakul
- D Moretti
- D Rindskopf
- E Slade
- EL Tsalik
- ES Garrett
- F Jaimes
- F Jaimes
- F Jaimes
- F Rodriguez
- Fabián A Jaimes
- FJ Molina
- G Matope
- GD De La Rosa
- Gisela D De La Rosa
- IA Meynaar
- J Kountchev
- JA Hanley
- JL Vincent
- JS Garner
- K Reinhart
- L Tuyisenge
- LR Nielsen
- LY Gamez-Diaz
- MA Hermans
- Marta L Valencia
- MM Levy
- MM Levy
- NM Buderer
- P Hausfater
- PJ Goebel
- R Uusitalo-Seppala
- RA Claus
- RP Dellinger
- S Riedel
- Sigifredo Ospina
- Susana C Osorno
- T van der Poll
- WA Knaus
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Use of Expert Panels to Define the Reference Standard in Diagnostic Research: A Systematic Review of Published Methods and Reporting
- Author
- A Hadgu
- A Liberati
- A Ogunniyi
- A Ogunniyi
- A van Randen
- AA Bankier
- AB Gaikwad
- AD Hardie
- AK Penzkofer
- AL Baughman
- AM Tadros
- Arno W. Hoes
- AW Rutjes
- BD Broekhuizen
- BD Broekhuizen
- Berna D. L. Broekhuizen
- BL Plassman
- BL Plassman
- C Carnero-Pardo
- C Girard
- CA Class
- Christiana A. Naaktgeboren
- CS White
- D Thabut
- D Weintraub
- Davina Ghersi
- DF Ransohoff
- F Bisulli
- F Gauvin
- F Jorgensen
- FA Mohamed Hoesein
- FH Rutten
- FJ Martinez
- FN Doubal
- Frans H. Rutten
- G Baird
- G Guder
- GG Potter
- H Ham
- HJ de Koning
- I Oudejans
- J Amour
- J Linn
- J Magaziner
- J Magaziner
- J Trevelyan
- J Williams
- JA de Groot
- JA Otte
- JB Reitsma
- JC Kelder
- JC Kelder
- JK Marshall
- Johannes B. Reitsma
- JV Laurila
- Karel G. M. Moons
- KE Nordenholz
- KG Moons
- KS Hall
- LM Weih
- Loes C. M. Bertens
- LY Gamez-Diaz
- M Boustani
- M Kantarci
- M Remy-Jardin
- M Tanenberg-Karant
- MJ Gabel
- MJ Geirnaerdt
- MS Pepe
- N Chavannes
- NA Obuchowski
- NK Steenland
- NR Graff-Radford
- OJ Bienvenu
- P Ray
- P Reinartz
- P Reinartz
- P Wiener
- PD Humphries
- PF Whiting
- PM Bossuyt
- PR Duberstein
- PR Miller
- PS Sachdev
- Q Dao
- R Hoffmann
- R Hoffmann
- RE Drake
- RG Assomull
- RJ Lilford
- RV O'Toole
- S Bosner
- S Fennig
- S Johnson
- SF Thieme
- SJ Gulevich
- SJ Tepper
- T Fladby
- TA Alonzo
- TA Robin
- TS Brugha
- U Hoffmann
- U Hoffmann
- WC Lin
- WN Whiteley
- Yvonne van Mourik
- Z Szucs-Farkas
- Publication venue
- 'Public Library of Science (PLoS)'
- Publication date
- Field of study
MicroRNAs as Mediators of Resistance Mechanisms to Small-Molecule Tyrosine Kinase Inhibitors in Solid Tumours
- Author
- A Ahmad
- A Carracedo
- A Gamez-Pozo
- A Mangolini
- A Salvi
- A Spitschak
- AA Farooqi
- AE Pasquinelli
- AE Siroy
- AK Gaumann
- Andrea Lampis
- B Escudier
- B Escudier
- B Fauvel
- B Kefas
- B Li
- B Ma
- B Zheng
- BJ Solomon
- BN Davis
- C Braconi
- C Corcoran
- C Gao
- C He
- C Prior
- C Stahlhut
- CD Blanke
- CE Geyer
- D Hanahan
- D Huang
- D Vishwamitra
- DH Park
- DJ Hicklin
- DJ Slamon
- DJ Slamon
- DT Chua
- E Izumchenko
- E Raymond
- EC Martin
- EL Kwak
- F Yang
- Francesco Trevisani
- G Zhang
- GD Demetri
- GD Demetri
- GG Gomez
- Gianluca Tomasello
- GJ Korpanty
- GJ Riely
- GJ Weiss
- H Shen
- H Xia
- H Xu
- H Zhao
- HN Vasudevan
- HY Sun
- J Azumi
- J Baselga
- J Berkers
- J Li
- J Luo
- J Shen
- J Wang
- JC Yao
- Jens C. Hahne
- JL Bryant
- JM Llovet
- JY Douillard
- JY Zhou
- K Kitamura
- K Mao
- K Ohta
- K Shien
- K Zhang
- KG Chen
- L Fattore
- L He
- L Huang
- L Liu
- L Liu
- L Sanchez-del-Campo
- L Sellmann
- LA Byers
- LP Lim
- LY Chau
- M Acunzo
- M Acunzo
- M Cao
- M Choura
- M Diaz-Martinez
- M Esteller
- M Garofalo
- M Garofalo
- M Garofalo
- M Hojjat-Farsangi
- M Lagos-Quintana
- M Lin
- M Luo
- M Maemondo
- M Nottage
- M Vitiello
- Melissa Frizziero
- Michele Ghidini
- MS Stark
- MV Iorio
- Nicola Valeri
- NP Agaram
- P Akcakaya
- P Ceppi
- PA Gregory
- PB Alexander
- PB Chapman
- Q Zhen
- R Fan
- R Haq
- R Rosell
- R Rupaimoole
- RE Bell
- RJ Motzer
- RJ Motzer
- RJ Motzer
- RJ Webster
- RM O'Connell
- Rodolfo Passalacqua
- S Bai
- S Donzelli
- S Lassalle
- S Romeo
- S Shimizu
- SA Wells Jr
- SY Wu
- T Sakurai
- TR Lunavat
- TS Mok
- V Balatti
- W Shi
- W Wang
- WC Cho
- WK Kim
- X Gao
- X Sun
- Y Goto
- Y Lin
- Y Shen
- Y Shi
- Y Wang
- Y Xu
- Y Zhang
- YS Wang
- Z Xiao
- ZF Zhang
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
HMGB1 in health and disease
- Author
- Abarbanell
- Abdul-Razzak
- Abdulahad
- Abdulahad
- Abdulahad
- Abe
- Abeyama
- Abraham
- Abraham
- Abraham
- Abu El-Asrar
- Abu El-Asrar
- Achouiti
- Adilakshmi
- Adjaye
- Adlesic
- af Klint
- Aggarwal
- Agnello
- Agrawal
- Agresti
- Agresti
- Agresti
- Aguilera
- Ahn
- Aidinis
- Aits
- Aizawa
- Akaike
- Akira
- Alami-Ouahabi
- Albayrak
- Albayrak
- Aleporou-Marinou
- Alexandrova
- Alexandrova
- Alexandrova
- Ali
- Aliahmad
- Aliahmad
- Aliahmad
- Allan Tsung
- Alleva
- Allonso
- Alves
- Amano
- Ammar
- An
- Anderson
- Andersson
- Andersson
- Andersson
- Andersson
- Andersson
- Andersson
- Andrassy
- Andrassy
- Andrews
- Aneja
- Angeletti
- Angus
- Angus
- Anon
- Antoine
- Antoine
- Antoine
- Antoine
- Antoine
- Antoine
- Apetoh
- Apetoh
- Apetrei
- Aravind
- Arends
- Arimura
- Arlotta
- Arnold
- Arrigo
- Asano
- Ashar
- Assenberg
- Atkinson
- Au
- Avalos
- Ayarci
- Aychek
- Bae
- Bae
- Baker
- Balani
- Balasubramani
- Balasubramaniam
- Bald
- Baldassarre
- Balosso
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- Bamboat
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- Banerjee
- Banerjee
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- Bardeesy
- Barkauskaite
- Barkess
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- Barnay-Verdier
- Barnes
- Barqasho
- Basta
- Battista
- Battista
- Bauer
- Bell
- Bellussi
- Bellussi
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- Bernales
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- Li
- Li
- Li
- Li
- Li
- Li
- Li
- Li
- Li
- Li
- Li
- Li
- Li
- Li
- Li
- Li
- Li
- Li
- Li
- Li
- Li
- Li
- Li
- Li
- Li
- Li
- Li
- Li
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- Liu
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- Perez-Martin
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- Wang
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- Wang
- Wang
- Wang
- Wang
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- Wang
- Wang
- Wang
- Wang
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- Wang
- Wang
- Wang
- Wang
- Wang
- Wang
- Wang
- Wang
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- Wu
- Wu
- Wu
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- Xiang
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- Xiao
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- Xiaofang Sun
- Xie
- Xie
- Xie
- Xie
- Xiong
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- Xu
- Xu
- Xu
- Xu
- Xu
- Xu
- Xu
- Xue-gong Fan
- Yamada
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- Yamada
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- Yamada
- Yamamoto
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- Zappavigna
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- Zetterstrom
- Zetterstrom
- Zetterstrom
- Zhai
- Zhan
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- Zhang
- Zhang
- Zhang
- Zhang
- Zhang
- Zhang
- Zhang
- Zhang
- Zhang
- Zhang
- Zhang
- Zhang
- Zhang
- Zhang
- Zhang
- Zhang
- Zhang
- Zhang
- Zhang
- Zhang
- Zhang
- Zhang
- Zhang
- Zhang
- Zhang
- Zhang
- Zhang
- Zhang
- Zhang
- Zhang
- Zhang
- Zhang
- Zhang
- Zhang
- Zhao
- Zhao
- Zhao
- Zhao
- Zhao
- Zheng
- Zhengwen Yan
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- Zhou
- Zhou
- Zhou
- Zhou
- Zhou
- Zhou
- Zhou
- Zhou
- Zhou
- Zhou
- Zhu
- Zhu
- Zhu
- Zhu
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- Zhu
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- Zicari
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- Zickert
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- Zimmermann
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