Ground Motion Study on Dumbarton Toll Bridge

The existing Dumbarton Toll Bridge was built in 1982, connecting the cities of Newark and East Palo Alto in the San Francisco Bay Area. The initial vulnerability studies conducted by California Department of Transportation (Caltrans) in 2004 indicated that the performance of the bridge during a maximum credible earthquake was uncertain. Earth Mechanics, Inc. (EMI) has carried out the necessary study for the seismic evaluation of the bridge. An extensive field investigation was undertaken both on-land and over-water at the site to develop the idealized subsurface profile along the bridge alignment. According to the probabilistic and deterministic seismic hazard analyses incorporated with new seismic source model and Next Generation Attenuation (NGA) models, a 1,000-year return period spectrum was adopted for the Safety Evaluation Earthquake (SEE) event and a 100-year return period spectrum for the Function Evaluation Earthquake (FEE) event. SHAKE and KIPS programs were used to conduct the seismic response analysis and kinematic soil-pile interaction analysis were carried out at selected piers. From this study, two sets of Acceleration Response Spectrum (ARS) curves were generated for the seismic retrofit of this bridge: one for the Main Channel piers and another for the West and East Approach structures. Other seismic retrofit-related issues are also addressed

Intelligent Point-of-Interest Recommendation for Tourism Planning via Density-based Clustering and Genetic Algorithm

In recent years, geographic information service and relevant social media become more popular, some geographic point may interest people, e.g. scenic spot or famous store, naming as a point-of-interest (POI). However, the number of POI contributing by social media grows exponentially which causing a searching problem. How to recommend a POI to a user/tourist becomes a challenge. This study proposes an intelligent system using density-based clustering and genetic algorithm to recommend a POIs solution for tourism planning. Density-based clustering identifies candidate POIs. Skyline method decides a superior POI from candidate POIs by dominant of multiple attributes. Genetic algorithm optimizes the recommendation solution. The contribution is to get a tourism POI solution from a huge amount of candidate POIs based on user/tourist preferences. An experimental system implementation is in progress. In future, we will use open data from Google map and Foursquare to proof the proposed system mechanism effectiveness

The Yuan-Tseh Lee Array for Microwave Background Anisotropy

The Yuan-Tseh Lee Array for Microwave Background Anisotropy (AMiBA) is the first interferometer dedicated to studying the cosmic microwave background (CMB) radiation at 3mm wavelength. The choice of 3mm was made to minimize the contributions from foreground synchrotron radiation and Galactic dust emission. The initial configuration of seven 0.6m telescopes mounted on a 6-m hexapod platform was dedicated in October 2006 on Mauna Loa, Hawaii. Scientific operations began with the detection of a number of clusters of galaxies via the thermal Sunyaev-Zel'dovich effect. We compare our data with Subaru weak lensing data in order to study the structure of dark matter. We also compare our data with X-ray data in order to derive the Hubble constant.Comment: accepted for publication in ApJ (13 pages, 7 figures); a version with high resolution figures available at http://www.asiaa.sinica.edu.tw/~keiichi/upfiles/AMiBA7/pho_highreso.pd

Functional characterization of cellulases identified from the cow rumen fungus Neocallimastix patriciarum W5 by transcriptomic and secretomic analyses

<p>Abstract</p> <p>Background</p> <p><it>Neocallimastix patriciarum</it> is one of the common anaerobic fungi in the digestive tracts of ruminants that can actively digest cellulosic materials, and its cellulases have great potential for hydrolyzing cellulosic feedstocks. Due to the difficulty in culture and lack of a genome database, it is not easy to gain a global understanding of the glycosyl hydrolases (<it>GHs</it>) produced by this anaerobic fungus.</p> <p>Results</p> <p>We have developed an efficient platform that uses a combination of transcriptomic and proteomic approaches to <it>N. patriciarum </it>to accelerate gene identification, enzyme classification and application in rice straw degradation. By conducting complementary studies of transcriptome (Roche 454 GS and Illumina GA IIx) and secretome (ESI-Trap LC-MS/MS), we identified 219 putative <it>GH </it>contigs and classified them into 25 <it>GH</it> families. The secretome analysis identified four major enzymes involved in rice straw degradation: β-glucosidase, endo-1,4-β-xylanase, xylanase B and Cel48A exoglucanase. From the sequences of assembled contigs, we cloned 19 putative cellulase genes, including the <it>GH1</it>, <it>GH3</it>, <it>GH5</it>, <it>GH6</it>, <it>GH9</it>, <it>GH18</it>, <it>GH43 </it>and <it>GH48 </it>gene families, which were highly expressed in <it>N. patriciarum </it>cultures grown on different feedstocks.</p> <p>Conclusions</p> <p>These <it>GH </it>genes were expressed in Pichia pastoris and/or Saccharomyces cerevisiae for functional characterization. At least five novel cellulases displayed cellulytic activity for glucose production. One β-glucosidase (W5-16143) and one exocellulase (W5-CAT26) showed strong activities and could potentially be developed into commercial enzymes.</p

AMiBA: System Performance

The Y.T. Lee Array for Microwave Background Anisotropy (AMiBA) started scientific operation in early 2007. This work describes the optimization of the system performance for the measurements of the Sunyaev-Zel'dovich effect for six massive galaxy clusters at redshifts $0.09 - 0.32$. We achieved a point source sensitivity of $63\pm 7$ mJy with the seven 0.6m dishes in 1 hour of on-source integration in 2-patch differencing observations. We measured and compensated for the delays between the antennas of our platform-mounted interferometer. Beam switching was used to cancel instrumental instabilities and ground pick up. Total power and phase stability were good on time scales of hours, and the system was shown to integrate down on equivalent timescales of 300 hours per baseline/correlation, or about 10 hours for the entire array. While the broadband correlator leads to good sensitivity, the small number of lags in the correlator resulted in poorly measured bandpass response. We corrected for this by using external calibrators (Jupiter and Saturn). Using Jupiter as the flux standard, we measured the disk brightness temperature of Saturn to be $149^{+5}_{-12}$ K.Comment: 9 pages, 7 figures, 1 table, accepted for publication in Ap

The AMiBA Hexapod Telescope Mount

AMiBA is the largest hexapod astronomical telescope in current operation. We present a description of this novel hexapod mount with its main mechanical components -- the support cone, universal joints, jack screws, and platform -- and outline the control system with the pointing model and the operating modes that are supported. The AMiBA hexapod mount performance is verified based on optical pointing tests and platform photogrammetry measurements. The photogrammetry results show that the deformations in the inner part of the platform are less than 120 micron rms. This is negligible for optical pointing corrections, radio alignment and radio phase errors for the currently operational 7-element compact configuration. The optical pointing error in azimuth and elevation is successively reduced by a series of corrections to about 0.4 arcmin rms which meets our goal for the 7-element target specifications.Comment: Accepted for ApJ, 33 pages, 15 figure

Women with endometriosis have higher comorbidities: Analysis of domestic data in Taiwan

AbstractEndometriosis, defined by the presence of viable extrauterine endometrial glands and stroma, can grow or bleed cyclically, and possesses characteristics including a destructive, invasive, and metastatic nature. Since endometriosis may result in pelvic inflammation, adhesion, chronic pain, and infertility, and can progress to biologically malignant tumors, it is a long-term major health issue in women of reproductive age. In this review, we analyze the Taiwan domestic research addressing associations between endometriosis and other diseases. Concerning malignant tumors, we identified four studies on the links between endometriosis and ovarian cancer, one on breast cancer, two on endometrial cancer, one on colorectal cancer, and one on other malignancies, as well as one on associations between endometriosis and irritable bowel syndrome, one on links with migraine headache, three on links with pelvic inflammatory diseases, four on links with infertility, four on links with obesity, four on links with chronic liver disease, four on links with rheumatoid arthritis, four on links with chronic renal disease, five on links with diabetes mellitus, and five on links with cardiovascular diseases (hypertension, hyperlipidemia, etc.). The data available to date support that women with endometriosis might be at risk of some chronic illnesses and certain malignancies, although we consider the evidence for some comorbidities to be of low quality, for example, the association between colon cancer and adenomyosis/endometriosis. We still believe that the risk of comorbidity might be higher in women with endometriosis than that we supposed before. More research is needed to determine whether women with endometriosis are really at risk of these comorbidities

Large expert-curated database for benchmarking document similarity detection in biomedical literature search

Document recommendation systems for locating relevant literature have mostly relied on methods developed a decade ago. This is largely due to the lack of a large offline gold-standard benchmark of relevant documents that cover a variety of research fields such that newly developed literature search techniques can be compared, improved and translated into practice. To overcome this bottleneck, we have established the RElevant LIterature SearcH consortium consisting of more than 1500 scientists from 84 countries, who have collectively annotated the relevance of over 180 000 PubMed-listed articles with regard to their respective seed (input) article/s. The majority of annotations were contributed by highly experienced, original authors of the seed articles. The collected data cover 76% of all unique PubMed Medical Subject Headings descriptors. No systematic biases were observed across different experience levels, research fields or time spent on annotations. More importantly, annotations of the same document pairs contributed by different scientists were highly concordant. We further show that the three representative baseline methods used to generate recommended articles for evaluation (Okapi Best Matching 25, Term Frequency-Inverse Document Frequency and PubMed Related Articles) had similar overall performances. Additionally, we found that these methods each tend to produce distinct collections of recommended articles, suggesting that a hybrid method may be required to completely capture all relevant articles. The established database server located at https://relishdb.ict.griffith.edu.au is freely available for the downloading of annotation data and the blind testing of new methods. We expect that this benchmark will be useful for stimulating the development of new powerful techniques for title and title/abstract-based search engines for relevant articles in biomedical research.Peer reviewe

The Physical Durability and Electrical Resistivity of Indiana Bottom Ash : Executive Summary

This research assessed the long-term performance (durability) and the environmental effect (corrosiveness to adjacent metal structures) of Indiana bottom ashes, based mainly on laboratory investigation. The 5-cycle sodium sulfate soundness tests and the 50-cycle freeze-thaw tests were conducted to examine the physical durability. Four electrochemical characteristics (electrical resistivity, pH, soluble chloride, and soluble sulfate) were used to estimate the corrosion potential of Indiana bottom ashes. Evaluation criteria for durability and corrosiveness of bottom ash, based on appropriate specifications for aggregates and past experiences for soils, were developed. The comparison of test results and the above criteria shows that Indiana bottom ashes are durable but may be corrosive. The bottom ashes with a high corrosion potential should not be utilized in highway construction where metal structures are involved