APLICATIVO “WEB-MOBILE”, DERIVADO DE MÉTODOS DE INTELIGÊNCIA ARTIFICIAL, PARA PREDIÇÃO DE DEFICIÊNCIA DE TESTOSTERONA EM HOMENS

A testosterona (T) é considerada o hormônio sexual mais importante na fisiologia masculina e tem um impacto significativo nos parâmetros físicos e psicológicos, sendo um importante indicador de boa saúde geral e qualidade de vida. Alguns pacientes podem apresentar deficiência de testosterona (TD), uma condição definida como a presença de níveis séricos baixos persistentes de T e sintomas clínicos Shalender et al. (2010)

ASSOCIAÇÃO DA RAZÃO NEUTRÓFILO - LINFÓCITO (NLR) E HIPERPLASIA PROSTÁTICA BENIGNA (HPB)

Hiperplasia Prostática Benigna (HPB) é a doença mais comum entre homens idosos com sintomas do trato urinário inferior (MCVARY, 2006). Sobre sua fisiopatologia, é bem conhecido e relatado o papel e função dos andrógenos e fatores de crescimento no início da progressão da HPB. Além desses componentes, a inflamação; principalmente a crônica, vem ganhando destaque como possível fator importante, influente no crescimento da próstata e progressão dos sintomas da HPB (OZER et al., 2017)

UM ESTUDO SOBRE A IMPORTÂNCIA DO DIAGNÓSTICO NA ESTOMATOLOGIA

Malignant oral diseases can be prevented if recognized early. Since most autoimmune lesions are not seen, they can first go unnoticed by the patient. The main factors that lead a patient to seek urgent dental care are the presence of severe injuries and their consequences, such as severe pain, along with internal trauma. Thus, a brief clinical examination that allows the exclusion of any silent lesion from the oral cavity becomes crucial. The research found that the clinical profile of patients analyzed and referred to the Stomatology Service reveals that many medical professionals still prefer that the same conditions be diagnosed and treated in a specialized center, often due to lack of methods to do a biopsy to confirm the diagnosis. The methodology used was a bibliographic study using available articles, dealing with clinical diagnosis and histopathological diagnosis of each lesion, method to obtain the diagnosis and conduct adopted, both issued by the said service, and finally, whether or not there was a new referral, to form criticism and reasoning regarding the pathological conditions that affect the oral cavity, expand knowledge of the management of patients with various diseases, including those with specific oral localization and those with systemic effects that include a dental component. Las enfermedades orales malignas se pueden prevenir si se reconocen temprano. Dado que la mayoría de las lesiones autoinmunes no se ven, primero pueden pasar desapercibidas para el paciente. Los principales factores que llevan a un paciente a buscar atención dental urgente son la presencia de lesiones graves y sus consecuencias, como dolor severo, junto con traumatismos internos. Por lo tanto, un breve examen clínico que permita la exclusión de cualquier lesión silenciosa de la cavidad oral se vuelve crucial. La investigación encontró que el perfil clínico de los pacientes analizados y remitidos al Servicio de Estomatología revela que muchos profesionales médicos todavía prefieren que las mismas condiciones sean diagnosticadas y tratadas en un centro especializado, a menudo debido a la falta de métodos para hacer una biopsia para confirmar el diagnóstico. La metodología utilizada fue un estudio bibliográfico utilizando artículos disponibles, que tratara sobre el diagnóstico clínico y el diagnóstico histopatológico de cada lesión, el método para obtener el diagnóstico y la conducta adoptada, ambos emitidos por dicho servicio, y finalmente, si hubo o no una nueva derivación, para formar críticas y razonamientos sobre las condiciones patológicas que afectan la cavidad oral, Ampliar el conocimiento del manejo de pacientes con diversas enfermedades, incluyendo aquellos con localización oral específica y aquellos con efectos sistémicos que incluyen un componente dental. Doenças orais malignas podem ser prevenidas se reconhecidas precocemente. Sendo a maioria das lesões autoimunes, elas podem passar primeiro despercebidas pelo paciente. Os principais fatores que levam um paciente a procurar atendimento odontológico de urgência são a presença de lesões graves e suas consequências, como dores intensas , juntamente com traumatismos internos. Assim, um breve exame clínico que permita a exclusão de qualquer lesão silenciosa da cavidade oral torna-se crucial. A pesquisa constatou que o perfil clínico dos pacientes analisados e encaminhados para o Serviço de Estomatologia revela que muitos profissionais médicos ainda preferem que as mesmas condições sejam diagnosticadas e tratadas em um centro especializado, muitas vezes por falta de métodos para fazer uma biópsia para confirmar o diagnóstico. A metodologia utilizada tratou-se de um estudo bibliográfico utilizando de artigos disponíveis, tratando sobre diagnóstico clínico e diagnóstico histopatológico de cada lesão, método para obtenção do diagnóstico e conduta adotada, ambos emitidos pelo referido serviço, e por fim, se houve ou não um novo encaminhamento, para formar a crítica e o raciocínio no que tange as condições patológicas que acometem a cavidade bucal, ampliar o conhecimento do manejo de pacientes com várias doenças, incluindo aquelas com localização oral específica e aquelas com efeitos sistêmicos que incluem um componente odontológico. Doenças orais malignas podem ser prevenidas se reconhecidas precocemente. Sendo a maioria das lesões autoimunes, elas podem passar primeiro despercebidas pelo paciente. Os principais fatores que levam um paciente a procurar atendimento odontológico de urgência são a presença de lesões graves e suas consequências, como dores intensas , juntamente com traumatismos internos. Assim, um breve exame clínico que permita a exclusão de qualquer lesão silenciosa da cavidade oral torna-se crucial. A pesquisa constatou que o perfil clínico dos pacientes analisados e encaminhados para o Serviço de Estomatologia revela que muitos profissionais médicos ainda preferem que as mesmas condições sejam diagnosticadas e tratadas em um centro especializado, muitas vezes por falta de métodos para fazer uma biópsia para confirmar o diagnóstico. A metodologia utilizada tratou-se de um estudo bibliográfico utilizando de artigos disponíveis, tratando sobre diagnóstico clínico e diagnóstico histopatológico de cada lesão, método para obtenção do diagnóstico e conduta adotada, ambos emitidos pelo referido serviço, e por fim, se houve ou não um novo encaminhamento, para formar a crítica e o raciocínio no que tange as condições patológicas que acometem a cavidade bucal, ampliar o conhecimento do manejo de pacientes com várias doenças, incluindo aquelas com localização oral específica e aquelas com efeitos sistêmicos que incluem um componente odontológico.

Expression of VEGF and collagen using a latex biomembrane as bladder replacement in rabbits

Objective: To investigate the VEGF expression and collagen deposition using a latex biomembrane as bladder replacement in rabbits. Materials and Methods: After partial cystectomy, a patch of a non-vulcanized latex biomembrane (2 x 2 cm) was sewn to the bladder of rabbits with 5/0 monofilament polydioxanone sulfate sutures in a watertight manner. Groups of 5 animals were killed at 15, 45 and 90 days after surgery and the bladder was removed. Sections of 5 mu m were cut and stained with picrosirius-red in order to estimate the amount of extracellular matrix in the graft. To confirm the presence of VEGF in tissues, protein expression was determined by immunohistochemistry. Results: No death, urinary leakage or graft extrusion occurred in any group. All bladders showed a spherical shape. A progressive reduction in the amount of collagen occurred in the graft area and was negatively and linearly correlated with time (p < 0.001). VEGF expression was higher in grafted areas when compared to controls at 15 and 45 days after surgery and decreased with time (p < 0.001). Conclusion: The latex biomembrane as a matrix for partial bladder replacement in rabbits promotes temporary collagen deposition and stimulates the angiogenic process

Sutura do menisco pela técnica all-inside com o dispositivo Fast-Fix

OBJECTIVE:The objective of this study is to evaluate the results and effectiveness of the technique of meniscal repair type all-inside using Fast-Fix device.METHODS:A retrospective cohort study evaluating 22 patients with meniscal surgery between January 2004 and December 2010 underwent meniscal repair technique for all-inside with the Fast-Fix device with or without ACL reconstruction. Function and quality of life outcomes were chosen by the IKDC and Lysholm score, before and postoperatively, and reoperation rates, relying to the time of final follow-up. Statistical analysis was performed using the Student's t test.RESULTS:The mean follow-up was 59 months (16-84). The Lysholm score showed 72% (16 patients) of excellent and good results (84-100 points), 27% (6 patients) fair (65-83 points) and no cases classified as poor (<64 points). According to the IKDC: 81% (18 patients) of excellent and good results (75-100 points), 18% of cases regular (50-75 points) and no patient had poor results (<50 points). There were no failures or complications.CONCLUSION:The technique of meniscal repair type all-inside using the Fast-Fix device is safe and effective for the treatment of meniscal lesions in the red zone or red-white with or without simultaneous ACL reconstruction, with good and excellent results in most patients Level 4 Study.OBJETIVO:Avaliar os resultados e a eficácia da técnica de reparo meniscal tipo all-inside com o uso do dispositivo FasT-Fix.MÉTODOS:Estudo de coorte retrospectivo com avaliação de 22 pacientes com lesão meniscal operados entre janeiro de 2004 e dezembro de 2010, submetidos ao reparo meniscal pela técnica all-inside com o dispositivo FasT-Fix e associados ou não à reconstrução do LCA. Função e qualidade de vida foram os desfechos escolhidos por meio dos questionários de Lysholm e IKDC, pré e pós-operatoriamente, além das taxas de reoperação, relevando-se o tempo de seguimento final. A análise estatística foi feita com o uso do teste t de Student.RESULTADOS:O tempo médio de seguimento foi de 59 meses (16-84). O escore de Lysholm apresentou 73% (16 pacientes) de excelentes e bons resultados (84-100 pontos), 27% (seis pacientes) regulares (65-83 pontos) e nenhum caso classificado como ruim (< 64 pontos). Segundo o IKDC: 82% (18 pacientes) de excelentes e bons resultados (75-100 pontos); 18% de casos regulares (50-75 pontos) e nenhum paciente obteve resultados ruins (< 50 pontos). Não ocorreram falhas ou complicações.CONCLUSÃO:A técnica de reparo meniscal tipo all-inside com o uso do dispositivo FasT-Fix, nos pacientes avaliados, se mostrou eficaz e segura para o tratamento das lesões de menisco na zona vermelha ou zona vermelho-branca associada ou não à reconstrução simultânea do LCA e apresentou resultados bons e excelentes na maioria dos pacientes.Universidade Federal de São Paulo (UNIFESP) Escola Paulista de Medicina Department of Orthopedics and TraumatologyUNIFESP-EPM Department of Orthopedics and TraumatologyUNIFESP, EPM, Department of Orthopedics and TraumatologyUNIFESP, EPM Department of Orthopedics and TraumatologySciEL

Large expert-curated database for benchmarking document similarity detection in biomedical literature search

Document recommendation systems for locating relevant literature have mostly relied on methods developed a decade ago. This is largely due to the lack of a large offline gold-standard benchmark of relevant documents that cover a variety of research fields such that newly developed literature search techniques can be compared, improved and translated into practice. To overcome this bottleneck, we have established the RElevant LIterature SearcH consortium consisting of more than 1500 scientists from 84 countries, who have collectively annotated the relevance of over 180 000 PubMed-listed articles with regard to their respective seed (input) article/s. The majority of annotations were contributed by highly experienced, original authors of the seed articles. The collected data cover 76% of all unique PubMed Medical Subject Headings descriptors. No systematic biases were observed across different experience levels, research fields or time spent on annotations. More importantly, annotations of the same document pairs contributed by different scientists were highly concordant. We further show that the three representative baseline methods used to generate recommended articles for evaluation (Okapi Best Matching 25, Term Frequency-Inverse Document Frequency and PubMed Related Articles) had similar overall performances. Additionally, we found that these methods each tend to produce distinct collections of recommended articles, suggesting that a hybrid method may be required to completely capture all relevant articles. The established database server located at https://relishdb.ict.griffith.edu.au is freely available for the downloading of annotation data and the blind testing of new methods. We expect that this benchmark will be useful for stimulating the development of new powerful techniques for title and title/abstract-based search engines for relevant articles in biomedical research.Peer reviewe

Neurological status predicts response to alpha-blockers in men with voiding dysfunction and Parkinson's disease

OBJECTIVES: To evaluate predictors of the response to doxazosin, a selective alpha-adrenoceptor antagonist, when used for the treatment of lower urinary tract symptoms in men with Parkinson's disease. METHODS: In a prospective study, 33 consecutive men (mean age 59.2±7.0 years) with Parkinson's disease and lower urinary tract symptoms were evaluated. Neurological dysfunction was assessed with the Unified Parkinson's Disease Rating Scale. Urological assessment was performed at baseline and after 12 weeks of treatment with 4 mg/day of extended-release doxazosin, including symptom evaluation with the International Continence Society male short-form questionnaire, an assessment of the impact of lower urinary tract symptoms on quality of life and urodynamics. Clinical and urodynamic predictors of response were specifically evaluated. RESULTS: Compared with the score at baseline, the total International Continence Society male short-form score was reduced after doxazosin administration, from 17.4±7.5 to 11.1±6.9 (p<0.001). The impact of lower urinary tract symptoms on quality of life was also significantly reduced, from 1.8±1.1 to 1.0±1.0 (p<0.001) and the maximum urinary flow varied from 9.3±4.4 to 11.2±4.6 ml/s (p = 0.025). The severity of neurological impairment was the only predictor of the clinical response. Additionally, patients with a Unified Parkinson's Disease Rating Scale score lower than 70 had a significantly higher chance of clinical improvement with doxazosin treatment than those with higher Unified Parkinson's Disease Rating Scale scores did (RR = 3.10, 95% CI = [1.15 to 5.37], p = 0.011). CONCLUSIONS: Doxazosin resulted in the improvement of lower urinary tract symptoms and the maximum flow rate and was well tolerated in men with Parkinson's disease. The response to treatment is dependent on the severity of neurological disability

The current burden of cytomegalovirus infection in kidney transplant recipients receiving no pharmacological prophylaxis

Abstract Cytomegalovirus (CMV) infection in kidney transplantation has changed its clinical spectrum, mostly due to the current and more effective immunosuppression. In the absence of preventive strategies it is associated with significant morbi-mortality. Objective: This study evaluated the incidence of CMV events and its effect on outcomes of kidney transplantation in recipients without pharmacological prophylaxis or targeted preemptive treatment. Results: The study cohort comprised 802 recipients of kidney transplants between 04/30/2014 and 04/30/2015. The majority received induction with anti-thymocyte globulin (81.5%), tacrolimus and prednisone in combination with either mycophenolate (46.3%) or azathioprine (53.7%). The overall incidence of CMV events was 42% (58.6% infection and 41.4% disease). Patients with CMV showed higher incidence of first treated acute rejection (19 vs. 11%, p = 0,001) compared with those without CMV but no differences in graft loss, death or loss to follow-up. The incidence of delayed graft function was higher (56% vs. 37%, p = 0.000) and the eGFR at 1 (41 ± 21 vs. 54 ± 28 ml/min, p = 0.000) and 12 months (50 ± 19 vs. 61 ± 29 ml/min, p = 0.000) were lower in patients with CMV. Recipients age (OR = 1.03), negative CMV serology (OR = 5.21) and use of mycophenolate (OR = 1.67) were associated with increased risk of CMV. Changes in immunosuppression was more often in patients with CMV (63% vs. 31%, p = 0.000). Conclusion: the incidence of CMV events was high and associated with higher incidence of acute rejection and changes in immunosuppression. Besides traditional risk factors, renal function at 1 month was independently associated with CMV infection

NEOTROPICAL CARNIVORES: a data set on carnivore distribution in the Neotropics

Mammalian carnivores are considered a key group in maintaining ecological health and can indicate potential ecological integrity in landscapes where they occur. Carnivores also hold high conservation value and their habitat requirements can guide management and conservation plans. The order Carnivora has 84 species from 8 families in the Neotropical region: Canidae; Felidae; Mephitidae; Mustelidae; Otariidae; Phocidae; Procyonidae; and Ursidae. Herein, we include published and unpublished data on native terrestrial Neotropical carnivores (Canidae; Felidae; Mephitidae; Mustelidae; Procyonidae; and Ursidae). NEOTROPICAL CARNIVORES is a publicly available data set that includes 99,605 data entries from 35,511 unique georeferenced coordinates. Detection/non-detection and quantitative data were obtained from 1818 to 2018 by researchers, governmental agencies, non-governmental organizations, and private consultants. Data were collected using several methods including camera trapping, museum collections, roadkill, line transect, and opportunistic records. Literature (peer-reviewed and grey literature) from Portuguese, Spanish and English were incorporated in this compilation. Most of the data set consists of detection data entries (n = 79,343; 79.7%) but also includes non-detection data (n = 20,262; 20.3%). Of those, 43.3% also include count data (n = 43,151). The information available in NEOTROPICAL CARNIVORES will contribute to macroecological, ecological, and conservation questions in multiple spatio-temporal perspectives. As carnivores play key roles in trophic interactions, a better understanding of their distribution and habitat requirements are essential to establish conservation management plans and safeguard the future ecological health of Neotropical ecosystems. Our data paper, combined with other large-scale data sets, has great potential to clarify species distribution and related ecological processes within the Neotropics. There are no copyright restrictions and no restriction for using data from this data paper, as long as the data paper is cited as the source of the information used. We also request that users inform us of how they intend to use the data