Evaluating Alzheimer's Disease Progression by Modeling Crosstalk Network Disruption

Aβ, tau and P-tau have been widely accepted as reliable markers for Alzheimer’s disease (AD). The crosstalk between these markers forms a complex network. AD may induce the integral variation and disruption of the network. The aim of this study was to develop a novel mathematic model based on a simplified crosstalk network to evaluate the disease progression of AD. The integral variation of the network is measured by three integral disruption parameters. The robustness of network is evaluated by network disruption probability. Presented results show that network disruption probability has a good linear relationship with Mini Mental State Examination (MMSE). The proposed model combined with Support vector machine (SVM) achieves a relative high 10-fold cross-validated performance in classification of AD vs normal and mild cognitive impairment (MCI) vs normal (95% accuracy, 95% sensitivity, 95% specificity for AD vs normal; 90% accuracy, 94% sensitivity, 83% specificity for MCI vs normal). This research evaluates the progression of AD and facilitates AD early diagnosis

A Novel Estimation Method for Temperature of Magnetic Nanoparticles Dominated by Brownian Relaxation Based on Magnetic Particle Spectroscopy

This paper presents a novel method for estimating the temperature of magnetic nanoparticles (MNPs) based on AC magnetization harmonics of MNPs dominated by Brownian relaxation. The difference in the AC magnetization response and magnetization harmonic between the Fokker-Planck equation and the Langevin function was analyzed, and we studied the relationship between the magnetization harmonic and the key factors, such as Brownian relaxation time, temperature, magnetic field strength, core size and hydrodynamic size of MNPs, excitation frequency, and so on. We proposed a compensation function for AC magnetization harmonic with consideration of the key factors and the difference between the Fokker-Planck equation and the Langevin function. Then a temperature estimation model based on the compensation function and the Langevin function was established. By employing the least squares algorithm, the temperature was successfully calculated. The experimental results show that the temperature error is less than 0.035 K in the temperature range from 310 K to 320 K. The temperature estimation model is expected to improve the performance of the magnetic nanoparticle thermometer and be applied to magnetic nanoparticle-mediated hyperthermia

Open X-Embodiment:Robotic learning datasets and RT-X models

Large, high-capacity models trained on diverse datasets have shown remarkable successes on efficiently tackling downstream applications. In domains from NLP to Computer Vision, this has led to a consolidation of pretrained models, with general pretrained backbones serving as a starting point for many applications. Can such a consolidation happen in robotics? Conventionally, robotic learning methods train a separate model for every application, every robot, and even every environment. Can we instead train "generalist" X-robot policy that can be adapted efficiently to new robots, tasks, and environments? In this paper, we provide datasets in standardized data formats and models to make it possible to explore this possibility in the context of robotic manipulation, alongside experimental results that provide an example of effective X-robot policies. We assemble a dataset from 22 different robots collected through a collaboration between 21 institutions, demonstrating 527 skills (160266 tasks). We show that a high-capacity model trained on this data, which we call RT-X, exhibits positive transfer and improves the capabilities of multiple robots by leveraging experience from other platforms. The project website is robotics-transformer-x.github.io

Large expert-curated database for benchmarking document similarity detection in biomedical literature search

Document recommendation systems for locating relevant literature have mostly relied on methods developed a decade ago. This is largely due to the lack of a large offline gold-standard benchmark of relevant documents that cover a variety of research fields such that newly developed literature search techniques can be compared, improved and translated into practice. To overcome this bottleneck, we have established the RElevant LIterature SearcH consortium consisting of more than 1500 scientists from 84 countries, who have collectively annotated the relevance of over 180 000 PubMed-listed articles with regard to their respective seed (input) article/s. The majority of annotations were contributed by highly experienced, original authors of the seed articles. The collected data cover 76% of all unique PubMed Medical Subject Headings descriptors. No systematic biases were observed across different experience levels, research fields or time spent on annotations. More importantly, annotations of the same document pairs contributed by different scientists were highly concordant. We further show that the three representative baseline methods used to generate recommended articles for evaluation (Okapi Best Matching 25, Term Frequency-Inverse Document Frequency and PubMed Related Articles) had similar overall performances. Additionally, we found that these methods each tend to produce distinct collections of recommended articles, suggesting that a hybrid method may be required to completely capture all relevant articles. The established database server located at https://relishdb.ict.griffith.edu.au is freely available for the downloading of annotation data and the blind testing of new methods. We expect that this benchmark will be useful for stimulating the development of new powerful techniques for title and title/abstract-based search engines for relevant articles in biomedical research.Peer reviewe

Reactive Power Optimization for Transient Voltage Stability in Energy Internet via Deep Reinforcement Learning Approach

The existence of high proportional distributed energy resources in energy Internet (EI) scenarios has a strong impact on the power supply-demand balance of the EI system. Decision-making optimization research that focuses on the transient voltage stability is of great significance for maintaining effective and safe operation of the EI. Within a typical EI scenario, this paper conducts a study of transient voltage stability analysis based on convolutional neural networks. Based on the judgment of transient voltage stability, a reactive power compensation decision optimization algorithm via deep reinforcement learning approach is proposed. In this sense, the following targets are achieved: the efficiency of decision-making is greatly improved, risks are identified in advance, and decisions are made in time. Simulations show the effectiveness of our proposed method

A Class of Control Strategies for Energy Internet Considering System Robustness and Operation Cost Optimization

Aiming at restructuring the conventional energy delivery infrastructure, the concept of energy Internet (EI) has become popular in recent years. Outstanding benefits from an EI include openness, robustness and reliability. Most of the existing literatures focus on the conceptual design of EI and are lack of theoretical investigation on developing specific control strategies for the operation of EI. In this paper, a class of control strategies for EI considering system robustness and operation cost optimization is investigated. Focusing on the EI system robustness issue, system parameter uncertainty, external disturbance and tracking error are taken into consideration, and we formulate such robust control issue as a structure specified mixed H2/H∞ control problem. When formulating the operation cost optimization problem, three aspects are considered: realizing the bottom-up energy management principle, reducing the cost involved by power delivery from power grid (PG) to microgrid (MG), and avoiding the situation of over-control. We highlight that this is the very first time that the above targets are considered simultaneously in the field of EI. The integrated control issue is considered in frequency domain and is solved by a particle swarm optimization (PSO) algorithm. Simulation results show that our proposed method achieves the targets