Late Triassic dinoflagellate cysts from the Northern Carnarvon Basin, Western Australia

The Late Triassic radiation of cyst-forming dinoflagellates in the Southern Hemisphere is investigated in the Northern Carnarvon Basin, Western Australia. This major depocentre, situated on the southern margin of the Tethys Ocean, accumulated extensive deltaic and shallow marine successions at this time, that frequently host early dinoflagellate cyst assemblages. Numerous petroleum exploration wells in the basin have penetrated the fluvially dominated Mungaroo Formation and shallow marine Brigadier Formation, of Anisian–Norian and Rhaetian ages, respectively. Consequently, huge numbers of cuttings and sidewall core samples from these northwest prograding deltaic systems are available for study. Many of the dinoflagellate cysts from the Mungaroo and Brigadier formations have not been taxonomically formalised, including many forms that are used in open nomenclature within the oil and gas industry. This study formally documents these occasionally abundant and diverse dinoflagellate cyst assemblages with the aim of providing a consistent taxonomic framework for future work on the Upper Triassic successions of the Northern Carnarvon Basin. This will aid the recognition of individual flooding events via their characteristic palynomorph signatures and help to build on significant recent advances in regional sequence stratigraphy. One new genus, 14 new dinoflagellate cyst species and one new subspecies are described from the most diverse Late Triassic dinoflagellate assemblage yet published. A further nine genera and 15 dinoflagellate species are also recorded from the Carnian–Rhaetian R. wigginsii, W. listeri, H. balmei, R. rhaetica and D. priscum dinoflagellate zones. The documented assemblages are not only significant biostratigraphically, but it is also postulated that high diversity Triassic dinoflagellate cyst associations were paleoclimatically controlled, and were likely confined to the temperate and cool temperate paleolatitudes

Widespread nearshore and shallow marine deposition within the Lower Jurassic Precipice Sandstone and Evergreen Formation in the Surat Basin, Australia

In the Surat Basin of eastern Australia, the Lower Jurassic Precipice Sandstone and Evergreen Formation are a highly prospective reservoir-seal pair for notional future carbon capture and storage. However, the succession remains poorly constrained from a paleodepositional standpoint and this has impacted the capacity to construct predictive reservoir models. Here we integrate sedimentological, ichnological, and palynological data from ten cores located across a large region of the northern and central basin to produce conceptual depositional models for the interval. Our analysis shows that the Lower Jurassic Series consists of fifteen recurring sedimentary facies that are arranged into six facies associations – braidplain, lower delta plain, subaqueous delta, delta-influenced shoreface, tidally-influenced shoreline, and restricted marine shoals. The facies associations occur in the context of large scale fluvio-deltaic systems that occupied the basin. These results are supported by ichnological indications of marine and brackish-water, a coastal suite of palynomorphs, and marine palynomorphs including rare dinocysts, acritarchs, and copepod fragments. The very low abundance of marine palynomorphs are confined to the upper portion of the Evergreen Formation, and in combination with the sedimentology and ichnology suggest that marine influence increased through time as the basin was filled. The elucidation of marine-influenced deposition contravenes all but the most recent facies interpretations of the Precipice Sandstone and Evergreen Formation, and suggests that the paleogeography of the Mesozoic of eastern Australia needs to be reconsidered. Importantly, the nearshore and shallow marine depositional affinity has important implications for the size, orientation, and distribution of geobodies when building geologically-realistic static reservoir models for dynamic flow simulation

On the variability of cold region flooding

Cold region hydrological systems exhibit complex interactions with both climate and the cryosphere. Improving knowledge on that complexity is essential to determine drivers of extreme events and to predict changes under altered climate conditions. This is particularly true for cold region flooding where independent shifts in both precipitation and temperature can have significant influence on high flows. This study explores changes in the magnitude and the timing of streamflow in 18 Swedish Sub-Arctic catchments over their full record periods available and a common period (1990-2013). The Mann-Kendall trend test was used to estimate changes in several hydrological signatures (e.g. annual maximum daily flow, mean summer flow, snowmelt onset). Further, trends in the flood frequency were determined by fitting an extreme value type I (Gumbel) distribution to test selected flood percentiles for stationarity using a generalized least squares regression approach.Results highlight shifts from snowmelt-dominated to rainfall-dominated flow regimes with all significant trends (at the 5% significance level) pointing toward (1) lower magnitudes in the spring flood; (2) earlier flood occurrence; (3) earlier snowmelt onset; and (4) decreasing mean summer flows. Decreasing trends in flood magnitude and mean summer flows suggest widespread permafrost thawing and are supported by increasing trends in annual minimum daily flows. Trends in selected flood percentiles showed an increase in extreme events over the full periods of record (significant for only four catchments), while trends were variable over the common period of data among the catchments. An uncertainty analysis emphasizes that the observed trends are highly sensitive to the period of record considered. As such, no clear overall regional hydrological response pattern could be determined suggesting that catchment response to regionally consistent changes in climatic drivers is strongly influenced by their physical characteristics

A pooled analysis of 10 case–control studies of melanoma and oral contraceptive use

Data regarding the effects of oral contraceptive use on women's risk of melanoma have been difficult to resolve. We undertook a pooled analysis of all case–control studies of melanoma in women completed as of July 1994 for which electronic data were available on oral contraceptive use along with other melanoma risk factors such as hair colour, sun sensitivity, family history of melanoma and sun exposure. Using the original data from each investigation (a total of 2391 cases and 3199 controls), we combined the study-specific odds ratios and standard errors to obtain a pooled estimate that incorporates inter-study heterogeneity. Overall, we observed no excess risk associated with oral contraceptive use for 1 year or longer compared to never use or use for less than 1 year (pooled odds ratio (pOR)=0.86; 95% CI=0.74–1.01), and there was no evidence of heterogeneity between studies. We found no relation between melanoma incidence and duration of oral contraceptive use, age began, year of use, years since first use or last use, or specifically current oral contraceptive use. In aggregate, our findings do not suggest a major role of oral contraceptive use on women's risk of melanoma

A case–control analysis of oral contraceptive use and breast cancer subtypes in the African American Breast Cancer Epidemiology and Risk Consortium

Abstract Introduction Recent oral contraceptive (OC) use has been consistently associated with increased risk of breast cancer, but evidence on specific breast cancer subtypes is sparse. Methods We investigated recency and duration of OC use in relation to molecular subtypes of breast cancer in a pooled analysis of data from the African American Breast Cancer Epidemiology and Risk Consortium. The study included 1,848 women with estrogen receptor-positive (ER+) breast cancer, 1,043 with ER-negative (ER-) breast cancer (including 494 triple negative (TN) tumors, which do not have receptors for estrogen, progesterone, and human epidermal growth factor 2), and 10,044 controls. Multivariable polytomous logistic regression models were used to estimate odds ratios (ORs) and 95% confidence intervals (CIs) for exposure categories relative to never use, controlling for potential confounding variables. Results OC use within the previous 5 years was associated with increased risk of ER+ (OR 1.46, 95% CI 1.18 to 1.81), ER- (OR 1.57, 95% CI 1.22 to 1.43), and TN (OR 1.78, 95% CI 1.25 to 2.53) breast cancer. The risk declined after cessation of use but was apparent for ER+ cancer for 15 to 19 years after cessation and for ER- breast cancer for an even longer interval after cessation. Long duration of use was also associated with increased risk of each subtype, particularly ER-. Conclusions Our results suggest that OC use, particularly recent use of long duration, is associated with an increased risk of ER+, ER-, and TN breast cancer in African American women. Research into mechanisms that explain these findings, especially the association with ER- breast cancer, is needed

A realist analysis of hospital patient safety in Wales:Applied learning for alternative contexts from a multisite case study

Background: Hospital patient safety is a major social problem. In the UK, policy responses focus on the introduction of improvement programmes that seek to implement evidence-based clinical practices using the Model for Improvement, Plan-Do-Study-Act cycle. Empirical evidence that the outcomes of such programmes vary across hospitals demonstrates that the context of their implementation matters. However, the relationships between features of context and the implementation of safety programmes are both undertheorised and poorly understood in empirical terms. Objectives: This study is designed to address gaps in conceptual, methodological and empirical knowledge about the influence of context on the local implementation of patient safety programmes. Design: We used concepts from critical realism and institutional analysis to conduct a qualitative comparative-intensive case study involving 21 hospitals across all seven Welsh health boards. We focused on the local implementation of three focal interventions from the 1000 Lives+ patient safety programme: Improving Leadership for Quality Improvement, Reducing Surgical Complications and Reducing Health-care Associated Infection. Our main sources of data were 160 semistructured interviews, observation and 1700 health policy and organisational documents. These data were analysed using the realist approaches of abstraction, abduction and retroduction. Setting: Welsh Government and NHS Wales. Participants: Interviews were conducted with 160 participants including government policy leads, health managers and professionals, partner agencies with strategic oversight of patient safety, advocacy groups and academics with expertise in patient safety. Main outcome measures: Identification of the contextual factors pertinent to the local implementation of the 1000 Lives+ patient safety programme in Welsh NHS hospitals. Results: An innovative conceptual framework harnessing realist social theory and institutional theory was produced to address challenges identified within previous applications of realist inquiry in patient safety research. This involved the development and use of an explanatory intervention–context–mechanism–agency–outcome (I-CMAO) configuration to illustrate the processes behind implementation of a change programme. Our findings, illustrated by multiple nested I-CMAO configurations, show how local implementation of patient safety interventions are impacted and modified by particular aspects of context: specifically, isomorphism, by which an intervention becomes adapted to the environment in which it is implemented; institutional logics, the beliefs and values underpinning the intervention and its source, and their perceived legitimacy among different groups of health-care professionals; and the relational structure and power dynamics of the functional group, that is, those tasked with implementing the initiative. This dynamic interplay shapes and guides actions leading to the normalisation or the rejection of the patient safety programme. Conclusions: Heightened awareness of the influence of context on the local implementation of patient safety programmes is required to inform the design of such interventions and to ensure their effective implementation and operationalisation in the day-to-day practice of health-care teams. Future work is required to elaborate our conceptual model and findings in similar settings where different interventions are introduced, and in different settings where similar innovations are implemented. Funding: The National Institute for Health Research Health Services and Delivery Research programme

Cryptic Middle to Late Jurassic marine incursions into northeastern Gondwana: an integrated sedimentological, ichnological and geochronological approach

Sedimentary deposits of the Great Australian Superbasin, extensively developed across eastern Australia and covering almost a fifth of the continent, chronicle a rich record of palaeoenvironmental changes in northeastern Gondwana through the Jurassic and basal Cretaceous (Berriasian to Barremian). However, aside from the Surat Basin in the southeastern sector of the superbasin, little of this record has been examined closely. Likewise, the chronostratigraphy of the northern superbasin succession is poorly constrained. This study documents palaeoenvironmental and palaeogeographic records of the Carpentaria Basin at the northern extremity of the superbasin by integrating detailed sedimentary facies analysis with ichnology, palynology and U-Pb detrital zircon geochronology. This new geochronological data provides a refined age framework for the basin. At broad scale, the succession records the transition from a mixed paralic/fluviatile setting (Middle to Late Jurassic) to fully marine (Early Cretaceous) conditions. The depositional surface during basin accumulation stood close to sea level for which minor fluctuations induced a complex facies mosaic resulting in marked lithostratigraphic diachroneity for the basin fill. Two hitherto undocumented, discrete transgressive marine intervals, in the Middle Jurassic (Bajocian-Bathonian) and Late Jurassic (~Kimmeridgian-Tithonian) are identified. The former correlates with marine influence recorded in the Eromanga and Surat basins, and reflects extensive marine ingression from the north into the superbasin. The latter correlates with previously documented marine influence in the southeastern Carpentaria basin and the Surat Basin, indicating that a southeasterly-directed marine seaway existed across the Great Australian Superbasin during the Middle to Late Jurassic

New age constraints support a K/Pg boundary interval on Vega Island, Antarctica: Implications for latest Cretaceous vertebrates and paleoenvironments

A second K/Pg boundary interval in the northern sector of the Antarctic Peninsula on Vega Island has been proposed, yet current temporal resolution of these strata prohibits direct testing of this hypothesis. To not only test for the existence of a K/Pg boundary on Vega Island but also provide increased age resolution for the associated vertebrate fauna (e.g., marine reptiles, nonavian dinosaurs, and avian dinosaurs), the Vega Island succession was intensively resampled. Stratigraphic investigation of the Cape Lamb Member of the Snow Hill Island Formation, and in particular, the overlying Sandwich Bluff Member of the López de Bertodano Formation, was conducted using biostratigraphy, strontium isotope stratigraphy, magnetostratigraphy, and detrital zircon geochronology. These data indicate a Late Campanian–early Maastrichtian age for the Cape Lamb Member and present three possible correlations to the global polarity time scale (GPTS) for the overlying Sandwich Bluff Member. The most plausible correlation, which is consistent with biostratigraphy, detrital zircon geochronology, sequence stratigraphy, and all but one of the Sr-isotope ages, correlates the base of the section to C31N and the top of the section with C29N, which indicates that the K/Pg boundary passes through the top of the unit. A second, less plausible option conflicts with the biostratigraphy and depends on a series of poorly defined magnetic reversals in the upper part of the stratigraphy that also correlates the section between C31N and C29R and again indicates an inclusive K/Pg boundary interval. The least likely correlation, which depends on favoring only a single Srisotope age at the top of the section over biostratigraphy, correlates the section between C31N and C30N and is inconsistent with an included K/Pg boundary interval. Although our preferred correlation is well supported, we failed to identify an Ir-anomaly, spherules/ impact ejecta, or other direct evidence typically used to define the precise position of a K/Pg boundary on Vega Island. This study does, however, confirm that Vegavis, from the base of the Sandwich Bluff Member, is the oldest (69.2–68.4 Ma) phylogenetically placed representative of the avian crown clade, and that marine vertebrates and nonavian dinosaurs persisted in Antarctica up to the terminal Cretaceous