Privacy in Practice: Private COVID-19 Detection in X-Ray Images

Machine learning (ML) can help fight the COVID-19 pandemic by enabling rapid screening of large volumes of chest X-ray images. To perform such data analysis while maintaining patient privacy, we create ML models that satisfy Differential Privacy (DP). Previous works exploring private COVID-19 ML models are in part based on small or skewed datasets, are lacking in their privacy guarantees, and do not investigate practical privacy. In this work, we therefore suggest several improvements to address these open gaps. We account for inherent class imbalances in the data and evaluate the utility-privacy trade-off more extensively and over stricter privacy budgets than in previous work. Our evaluation is supported by empirically estimating practical privacy leakage through actual attacks. Based on theory, the introduced DP should help limit and mitigate information leakage threats posed by black-box Membership Inference Attacks (MIAs). Our practical privacy analysis is the first to test this hypothesis on the COVID-19 detection task. In addition, we also re-examine the evaluation on the MNIST database. Our results indicate that based on the task-dependent threat from MIAs, DP does not always improve practical privacy, which we show on the COVID-19 task. The results further suggest that with increasing DP guarantees, empirical privacy leakage reaches an early plateau and DP therefore appears to have a limited impact on MIA defense. Our findings identify possibilities for better utility-privacy trade-offs, and we thus believe that empirical attack-specific privacy estimation can play a vital role in tuning for practical privacy

Design and performance evaluation of next generation clutch control valve

Pressure reducing valves perform various control tasks in mobile machines. In many cases contamination sensitive environments require pilot-operated valves, because of its more robust performance. On the other hand, dynamic valve behavior can be critically in certain applications. Overcoming the restrictions resulting from stand-alone test rig attempts, suitable simulation principles are nowadays the state of art in valve design. Unsuitable model approaches and missing consideration of the application may result in wrong design decisions. This paper discusses two important modeling issues, in particular the solenoid and spool leakage behavior, in combination with the connected system under control, a pressure-actuated clutch. It is shown, that even for standard proportional valves a critical view on customers´excitation strategy and site of installation decides on success or failure of an already used design variant

Gleiche Sicherheit für alle statt NATO-Vorherrschaft: Beiträge zum 17. Dresdner Friedenssymposium am 21. Februar 2009

Die Projektgruppe „Für eine Globale Friedensordnung“ stellt im Dresdener Friedenssymposium Arbeitsergebnisse vor.:Gerda Krause, Eröffnung. Autorenbeiträge: Peter Strutynsky, Die Globalisierung der NATO oder die Militarisierung des Globus. Erhard Crome, Gleiche Sicherheit für alle - Alternativen zur NATO. Manfred Sauer, NATO – nicht die Sicherheit, die wir meinen. Horst Schneider, Gedanken zum Kolloquiumsthema Gleiche Sicherheit für alle statt NATO-Vorherrschaft. Nachträglich eingereichter Beitrag zum 13. Dresdner Symposium Für eine globale Friedensordnung, Heft 93/2009: Detlef Bald, Das Beispiel vom Primat der Politik – Die Kontrolle der Atomwaffen in der Bonner Republik

Slip of the tongue: implications for evolution and language development

prevailing theory regarding the evolution of language implicates a gestural stage prior to the emergence of speech. In support of a transition of human language from a gestural to a vocal system, articulation of the hands and the tongue are underpinned by overlapping left hemisphere dominant neural regions. Behavioral studies demonstrate that human adults perform sympathetic mouth actions in imitative synchrony with manual actions. Additionally, right-handedness for precision manual actions in children has been corre- lated with the typical development of language, while a lack of hand bias has been associ- ated with psychopathology. It therefore stands to reason that sympathetic mouth actions during fine precision motor action of the hands may be lateralized. We employed a fine-grained behavioral coding paradigm to provide the first investigation of tongue pro- trusions in typically developing 4-year old children. Tongue protrusions were investigated across a range of cognitive tasks that required varying degrees of manual action: precision motor action, gross motor action and no motor actions. The rate of tongue protrusions was influenced by the motor requirements of the task and tongue protrusions were signifi- cantly right-biased for only precision manual motor action (p < .001). From an evolutionary perspective, tongue protrusions can drive new investigations regarding how an early human communication system transitioned from hand to mouth. From a developmental perspective, the present study may serve to reveal patterns of tongue protrusions during the motor development of typically developing children

The unexpected resurgence of Weyl geometry in late 20-th century physics

Weyl's original scale geometry of 1918 ("purely infinitesimal geometry") was withdrawn by its author from physical theorizing in the early 1920s. It had a comeback in the last third of the 20th century in different contexts: scalar tensor theories of gravity, foundations of gravity, foundations of quantum mechanics, elementary particle physics, and cosmology. It seems that Weyl geometry continues to offer an open research potential for the foundations of physics even after the turn to the new millennium.Comment: Completely rewritten conference paper 'Beyond Einstein', Mainz Sep 2008. Preprint ELHC (Epistemology of the LHC) 2017-02, 92 pages, 1 figur

Prolonged Influenza Virus Shedding and Emergence of Antiviral Resistance in Immunocompromised Patients and Ferrets

Immunocompromised individuals tend to suffer from influenza longer with more serious complications than otherwise healthy patients. Little is known about the impact of prolonged infection and the efficacy of antiviral therapy in these patients. Among all 189 influenza A virus infected immunocompromised patients admitted to ErasmusMC, 71 were hospitalized, since the start of the 2009 H1N1 pandemic. We identified 11 (15%) cases with prolonged 2009 pandemic virus replication (longer than 14 days), despite antiviral therapy. In 5 out of these 11 (45%) cases oseltamivir resistant H275Y viruses emerged. Given the inherent difficulties in studying antiviral efficacy in immunocompromised patients, we have infected immunocompromised ferrets with either wild-type, or oseltamivir-resistant (H275Y) 2009 pandemic virus. All ferrets showed prolonged virus shedding. In wild-type virus infected animals treated with oseltamivir, H275Y resistant variants emerged within a week after infection. Unexpectedly, oseltamivir therapy still proved to be partially protective in animals infected with resistant virus. Immunocompromised ferrets offer an attractive alternative to study efficacy of novel antiviral therapies

Synthesis of 5-Hydroxyectoine from Ectoine: Crystal Structure of the Non-Heme Iron(II) and 2-Oxoglutarate-Dependent Dioxygenase EctD

As a response to high osmolality, many microorganisms synthesize various types of compatible solutes. These organic osmolytes aid in offsetting the detrimental effects of low water activity on cell physiology. One of these compatible solutes is ectoine. A sub-group of the ectoine producer's enzymatically convert this tetrahydropyrimidine into a hydroxylated derivative, 5-hydroxyectoine. This compound also functions as an effective osmostress protectant and compatible solute but it possesses properties that differ in several aspects from those of ectoine. The enzyme responsible for ectoine hydroxylation (EctD) is a member of the non-heme iron(II)-containing and 2-oxoglutarate-dependent dioxygenases (EC 1.14.11). These enzymes couple the decarboxylation of 2-oxoglutarate with the formation of a high-energy ferryl-oxo intermediate to catalyze the oxidation of the bound organic substrate. We report here the crystal structure of the ectoine hydroxylase EctD from the moderate halophile Virgibacillus salexigens in complex with Fe3+ at a resolution of 1.85 Å. Like other non-heme iron(II) and 2-oxoglutarate dependent dioxygenases, the core of the EctD structure consists of a double-stranded β-helix forming the main portion of the active-site of the enzyme. The positioning of the iron ligand in the active-site of EctD is mediated by an evolutionarily conserved 2-His-1-carboxylate iron-binding motif. The side chains of the three residues forming this iron-binding site protrude into a deep cavity in the EctD structure that also harbours the 2-oxoglutarate co-substrate-binding site. Database searches revealed a widespread occurrence of EctD-type proteins in members of the Bacteria but only in a single representative of the Archaea, the marine crenarchaeon Nitrosopumilus maritimus. The EctD crystal structure reported here can serve as a template to guide further biochemical and structural studies of this biotechnologically interesting enzyme family

Opera and Hypnosis: Victor Maurel’s Experiments with Verdi’s Otello

One day in his private home on the avenue Bugeaud, in Paris’s sixteenth arrondissement, the famous baritone Victor Maurel hosted a meeting which combined music with hypnotism of a young woman

Vocal Culture in the Age of Laryngoscopy

For several months beginning in 1884, readers of Life, Science, Health, the Atlantic Monthly and similar magazines would have encountered half-page advertisements for a newly patented medical device called the ‘ammoniaphone’ (Figure 2.1). Invented and promoted by a Scottish doctor named Carter Moffat and endorsed by the soprano Adelina Patti, British Prime Minister William Gladstone and the Princess of Wales, the ammoniaphone promised a miraculous transformation in the voices of its users. It was recommended for ‘vocalists, clergymen, public speakers, parliamentary men, readers, reciters, lecturers, leaders of psalmody, schoolmasters, amateurs, church choirs, barristers, and all persons who have to use their voices professionally, or who desire to greatly improve their speaking or singing tones’. Some estimates indicated that Moffat sold upwards of 30,000 units, yet the ammoniaphone was a flash in the pan as far as such things go, fading from public view after 1886